MAGEA9B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MAGEA9B is a duplication of the MAGEA9 gene (MIM 300342) on chromosome Xq28. The 2 copies are separated by about 194 kb (Hartz, 2009). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.42599414
2nuclear pore organization (GO:0006999)5.72983155
3DNA replication checkpoint (GO:0000076)5.48951321
4response to pheromone (GO:0019236)5.48260266
5regulation of translational fidelity (GO:0006450)5.15613096
6DNA unwinding involved in DNA replication (GO:0006268)5.04368250
7gonadal mesoderm development (GO:0007506)4.95750867
8pore complex assembly (GO:0046931)4.77109522
9synapsis (GO:0007129)4.62779481
10mitotic sister chromatid segregation (GO:0000070)4.60409201
11mitotic nuclear envelope disassembly (GO:0007077)4.44268182
12DNA strand elongation involved in DNA replication (GO:0006271)4.38915003
13sister chromatid segregation (GO:0000819)4.35921325
14formation of translation preinitiation complex (GO:0001731)4.33369814
15DNA replication initiation (GO:0006270)4.21399023
16DNA strand elongation (GO:0022616)4.21084737
17DNA topological change (GO:0006265)4.16535212
18membrane disassembly (GO:0030397)4.09047591
19nuclear envelope disassembly (GO:0051081)4.09047591
20regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.92938691
21regulation of RNA export from nucleus (GO:0046831)3.92042770
22telomere maintenance via semi-conservative replication (GO:0032201)3.90402751
23regulation of histone H3-K27 methylation (GO:0061085)3.90289449
24oxidative phosphorylation (GO:0006119)3.88064081
25mitotic chromosome condensation (GO:0007076)3.84756193
26folic acid-containing compound biosynthetic process (GO:0009396)3.82307991
27purine nucleobase biosynthetic process (GO:0009113)3.80606566
28ribosome biogenesis (GO:0042254)3.76490145
29nucleobase biosynthetic process (GO:0046112)3.70259103
30diterpenoid biosynthetic process (GO:0016102)3.65691500
31protoporphyrinogen IX metabolic process (GO:0046501)3.61764760
32IMP biosynthetic process (GO:0006188)3.58996283
33viral mRNA export from host cell nucleus (GO:0046784)3.57969359
34resolution of meiotic recombination intermediates (GO:0000712)3.53742017
35tRNA aminoacylation for protein translation (GO:0006418)3.49961684
36maturation of 5.8S rRNA (GO:0000460)3.48692098
37ribonucleoprotein complex biogenesis (GO:0022613)3.47599715
38mitotic recombination (GO:0006312)3.47435451
39telomere maintenance via recombination (GO:0000722)3.47417791
40regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.44654966
41ribosomal large subunit biogenesis (GO:0042273)3.43009469
42meiotic chromosome segregation (GO:0045132)3.42927884
43gas transport (GO:0015669)3.42410248
44amino acid activation (GO:0043038)3.39658397
45tRNA aminoacylation (GO:0043039)3.39658397
46regulation of histone H3-K4 methylation (GO:0051569)3.34369731
47IMP metabolic process (GO:0046040)3.28448978
48intra-S DNA damage checkpoint (GO:0031573)3.28360621
49mitotic metaphase plate congression (GO:0007080)3.27460647
50protein localization to kinetochore (GO:0034501)3.26326871
51ribosome assembly (GO:0042255)3.23768607
52chromosome segregation (GO:0007059)3.20042222
53erythrocyte development (GO:0048821)3.19839230
54tetrahydrofolate metabolic process (GO:0046653)3.18593164
55DNA damage induced protein phosphorylation (GO:0006975)3.17562809
56Golgi transport vesicle coating (GO:0048200)3.16571611
57COPI coating of Golgi vesicle (GO:0048205)3.16571611
58maturation of SSU-rRNA (GO:0030490)3.16220812
59homocysteine metabolic process (GO:0050667)3.15169466
60terpenoid biosynthetic process (GO:0016114)3.13891863
61regulation of nucleobase-containing compound transport (GO:0032239)3.10628313
62granulocyte differentiation (GO:0030851)3.07941158
63CENP-A containing nucleosome assembly (GO:0034080)3.05726972
64protein localization to chromosome, centromeric region (GO:0071459)3.05415135
65proline biosynthetic process (GO:0006561)3.04844475
66nuclear envelope organization (GO:0006998)3.04429418
67regulation of translational elongation (GO:0006448)3.03524771
68ribosomal small subunit biogenesis (GO:0042274)3.00346206
69regulation of DNA endoreduplication (GO:0032875)2.99603007
70mitotic sister chromatid cohesion (GO:0007064)2.99480642
71ribosomal small subunit assembly (GO:0000028)2.99236051
72protoporphyrinogen IX biosynthetic process (GO:0006782)2.98386396
73DNA replication-independent nucleosome assembly (GO:0006336)2.98104775
74DNA replication-independent nucleosome organization (GO:0034724)2.98104775
75regulation of chromosome segregation (GO:0051983)2.95714776
76regulation of centrosome cycle (GO:0046605)2.95567073
77telomere maintenance via telomere lengthening (GO:0010833)2.91683922
78oxygen transport (GO:0015671)2.90749017
79mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.89577677
80regulation of sister chromatid cohesion (GO:0007063)2.89022184
81regulation of centriole replication (GO:0046599)2.88928137
82kinetochore organization (GO:0051383)2.88769951
83aerobic respiration (GO:0009060)2.88137141
84proteasome assembly (GO:0043248)2.88035821
85translational termination (GO:0006415)2.85819139
86viral transcription (GO:0019083)2.85460485
87DNA duplex unwinding (GO:0032508)2.85043409
88chromatin remodeling at centromere (GO:0031055)2.83754280
89DNA conformation change (GO:0071103)2.83622769
90pteridine-containing compound biosynthetic process (GO:0042559)2.82890272
91translational initiation (GO:0006413)2.82222840
92chromatin assembly or disassembly (GO:0006333)2.81988388
93positive regulation of DNA-dependent DNA replication (GO:2000105)2.80945037
94nucleotide-excision repair, DNA gap filling (GO:0006297)2.80722888
95protein export from nucleus (GO:0006611)2.79721213
96chromosome condensation (GO:0030261)2.79585215
97DNA geometric change (GO:0032392)2.79377246
98establishment of integrated proviral latency (GO:0075713)2.77185817
99double-strand break repair via nonhomologous end joining (GO:0006303)2.76523335
100non-recombinational repair (GO:0000726)2.76523335

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.00125512
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.05739131
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.85955557
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.82807032
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.79075694
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.44078921
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.37525631
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.10024617
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.99365248
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.93682414
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.90186920
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.80112944
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79894998
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.71580149
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69492746
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65364163
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54950680
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.52874082
19XRN2_22483619_ChIP-Seq_HELA_Human2.36383766
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.30424126
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.22872165
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.20113962
23DCP1A_22483619_ChIP-Seq_HELA_Human2.16323583
24ELK1_19687146_ChIP-ChIP_HELA_Human2.13384024
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.11820695
26TTF2_22483619_ChIP-Seq_HELA_Human2.10804847
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07845475
28AR_21909140_ChIP-Seq_LNCAP_Human2.06940381
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03705314
30NCOR1_26117541_ChIP-Seq_K562_Human1.99877867
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.99478043
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.92011707
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85537416
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84937358
35VDR_23849224_ChIP-Seq_CD4+_Human1.78567924
36FOXP3_21729870_ChIP-Seq_TREG_Human1.77495670
37KDM5A_27292631_Chip-Seq_BREAST_Human1.77368483
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76491627
39GATA1_22025678_ChIP-Seq_K562_Human1.74386808
40GABP_19822575_ChIP-Seq_HepG2_Human1.73970462
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68528427
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64235395
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.62588944
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60850323
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59985579
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.59287073
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56616275
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52168186
49ZNF263_19887448_ChIP-Seq_K562_Human1.51405759
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46538505
51GATA1_19941826_ChIP-Seq_K562_Human1.46241866
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44534592
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39904511
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39175151
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37800038
56CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.36684413
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36634047
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34769449
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34764983
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34535209
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.33625675
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.26755621
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25869526
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24470458
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24368679
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22069108
67CIITA_25753668_ChIP-Seq_RAJI_Human1.22049308
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19850262
69MYC_18940864_ChIP-ChIP_HL60_Human1.15376259
70TFEB_21752829_ChIP-Seq_HELA_Human1.11442672
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08484438
72MYC_22102868_ChIP-Seq_BL_Human1.06947723
73CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05547418
74CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05100980
75GATA2_19941826_ChIP-Seq_K562_Human1.03331234
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01106462
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98881406
78ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98090804
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96439542
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94785953
81CHD1_26751641_Chip-Seq_LNCaP_Human0.94271484
82TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91634265
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91103800
84SALL1_21062744_ChIP-ChIP_HESCs_Human0.86984667
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86733081
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79214899
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79152747
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78748988
89SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77088969
90PKCTHETA_26484144_Chip-Seq_BREAST_Human0.76843753
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76252031
92SOX17_20123909_ChIP-Seq_XEN_Mouse0.75292674
93GATA4_21415370_ChIP-Seq_HL-1_Mouse0.72954398
94SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.72546555
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.68917855
96KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.68917855
97KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.68917855
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.65988647
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.65958979
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.65542387

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.01724260
2MP0004957_abnormal_blastocyst_morpholog4.31441401
3MP0010094_abnormal_chromosome_stability4.08286434
4MP0003111_abnormal_nucleus_morphology3.97068347
5MP0004147_increased_porphyrin_level3.85716785
6MP0005451_abnormal_body_composition3.73145442
7MP0008995_early_reproductive_senescence3.28500601
8MP0008058_abnormal_DNA_repair3.27803486
9MP0008057_abnormal_DNA_replication3.18150050
10MP0003077_abnormal_cell_cycle2.95961818
11MP0008932_abnormal_embryonic_tissue2.82485128
12MP0008007_abnormal_cellular_replicative2.34297053
13MP0009697_abnormal_copulation2.18451801
14MP0003786_premature_aging2.14023395
15MP0001730_embryonic_growth_arrest2.13901972
16MP0000678_abnormal_parathyroid_gland2.03901850
17MP0005171_absent_coat_pigmentation2.03470195
18MP0005408_hypopigmentation2.03367941
19MP0002396_abnormal_hematopoietic_system2.02855573
20MP0000350_abnormal_cell_proliferation1.92208406
21MP0003656_abnormal_erythrocyte_physiolo1.89096054
22MP0003136_yellow_coat_color1.88140990
23MP0003806_abnormal_nucleotide_metabolis1.87710900
24MP0002132_abnormal_respiratory_system1.87045462
25MP0003890_abnormal_embryonic-extraembry1.80992739
26MP0003718_maternal_effect1.78872554
27MP0001697_abnormal_embryo_size1.78087071
28MP0010307_abnormal_tumor_latency1.72399716
29MP0001661_extended_life_span1.64125503
30MP0001672_abnormal_embryogenesis/_devel1.62278642
31MP0005380_embryogenesis_phenotype1.62278642
32MP0002080_prenatal_lethality1.56321494
33MP0000313_abnormal_cell_death1.54113786
34MP0000372_irregular_coat_pigmentation1.50421031
35MP0002877_abnormal_melanocyte_morpholog1.49103659
36MP0002210_abnormal_sex_determination1.49051560
37MP0005257_abnormal_intraocular_pressure1.47284074
38MP0001545_abnormal_hematopoietic_system1.45072812
39MP0005397_hematopoietic_system_phenotyp1.45072812
40MP0006036_abnormal_mitochondrial_physio1.44439833
41MP0003984_embryonic_growth_retardation1.44297416
42MP0005076_abnormal_cell_differentiation1.43315150
43MP0006035_abnormal_mitochondrial_morpho1.42026966
44MP0008877_abnormal_DNA_methylation1.39082938
45MP0002088_abnormal_embryonic_growth/wei1.37832443
46MP0001929_abnormal_gametogenesis1.37349001
47MP0002086_abnormal_extraembryonic_tissu1.32608371
48MP0002084_abnormal_developmental_patter1.28663897
49MP0002085_abnormal_embryonic_tissue1.23068435
50MP0003186_abnormal_redox_activity1.19947721
51MP0003221_abnormal_cardiomyocyte_apopto1.17276081
52MP0003941_abnormal_skin_development1.08657547
53MP0001145_abnormal_male_reproductive1.07248459
54MP0004145_abnormal_muscle_electrophysio1.06051630
55MP0003385_abnormal_body_wall1.05681623
56MP0004808_abnormal_hematopoietic_stem1.04341515
57MP0004264_abnormal_extraembryonic_tissu1.00266684
58MP0005083_abnormal_biliary_tract0.99670115
59MP0004197_abnormal_fetal_growth/weight/0.99583117
60MP0000653_abnormal_sex_gland0.97018496
61MP0003959_abnormal_lean_body0.92912334
62MP0000647_abnormal_sebaceous_gland0.91486145
63MP0002095_abnormal_skin_pigmentation0.88476723
64MP0004233_abnormal_muscle_weight0.88453126
65MP0003698_abnormal_male_reproductive0.88274507
66MP0000358_abnormal_cell_content/0.88016348
67MP0004782_abnormal_surfactant_physiolog0.83655924
68MP0002019_abnormal_tumor_incidence0.83069780
69MP0003699_abnormal_female_reproductive0.80423665
70MP0008770_decreased_survivor_rate0.78587099
71MP0001727_abnormal_embryo_implantation0.78557799
72MP0001881_abnormal_mammary_gland0.76589877
73MP0002161_abnormal_fertility/fecundity0.76371684
74MP0010352_gastrointestinal_tract_polyps0.74894083
75MP0005636_abnormal_mineral_homeostasis0.73258078
76MP0006292_abnormal_olfactory_placode0.72540135
77MP0000703_abnormal_thymus_morphology0.72375330
78MP0004185_abnormal_adipocyte_glucose0.71452616
79MP0000747_muscle_weakness0.70415107
80MP0002269_muscular_atrophy0.69242558
81MP0002796_impaired_skin_barrier0.67115717
82MP0003937_abnormal_limbs/digits/tail_de0.66439727
83MP0002938_white_spotting0.66172871
84MP0005410_abnormal_fertilization0.65041062
85MP0002249_abnormal_larynx_morphology0.63879835
86MP0003950_abnormal_plasma_membrane0.63766531
87MP0002111_abnormal_tail_morphology0.62923007
88MP0003646_muscle_fatigue0.59840019
89MP0009115_abnormal_fat_cell0.58345263
90MP0005501_abnormal_skin_physiology0.58164163
91MP0009672_abnormal_birth_weight0.58023602
92MP0008872_abnormal_physiological_respon0.58023155
93MP0009931_abnormal_skin_appearance0.58013768
94MP0000609_abnormal_liver_physiology0.56669275
95MP0000631_abnormal_neuroendocrine_gland0.55977672
96MP0009703_decreased_birth_body0.55596257
97MP0003942_abnormal_urinary_system0.55305933
98MP0001764_abnormal_homeostasis0.52823718
99MP0003935_abnormal_craniofacial_develop0.52586694
100MP0003567_abnormal_fetal_cardiomyocyte0.52490809

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)5.07987823
2Abnormal gallbladder physiology (HP:0012438)5.07987823
3Truncus arteriosus (HP:0001660)4.87021230
4Birth length less than 3rd percentile (HP:0003561)4.68873836
5Reticulocytosis (HP:0001923)4.50829180
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.39657572
7Abnormality of reticulocytes (HP:0004312)4.36853783
8Chromsome breakage (HP:0040012)4.36662397
9Abnormality of homocysteine metabolism (HP:0010919)4.21233374
10Homocystinuria (HP:0002156)4.21233374
11Reticulocytopenia (HP:0001896)4.07350168
12Hyperthyroidism (HP:0000836)3.94793965
13Ankyloglossia (HP:0010296)3.92871030
14Duplicated collecting system (HP:0000081)3.79446415
15Short middle phalanx of the 5th finger (HP:0004220)3.53668670
16Polycythemia (HP:0001901)3.51406487
17Bowel incontinence (HP:0002607)3.47079968
18Abnormal hemoglobin (HP:0011902)3.44182314
19Pallor (HP:0000980)3.38451053
20Abnormality of the heme biosynthetic pathway (HP:0010472)3.37861319
21Abnormal large intestine physiology (HP:0012700)3.33099694
22Abnormality of the renal collecting system (HP:0004742)3.27117930
23Abnormality of glycolysis (HP:0004366)3.09172823
24Poikilocytosis (HP:0004447)3.04310502
25Acanthocytosis (HP:0001927)2.95330524
26Pheochromocytoma (HP:0002666)2.92314299
27Seborrheic dermatitis (HP:0001051)2.91335711
28Increased serum pyruvate (HP:0003542)2.89450738
29Cortical dysplasia (HP:0002539)2.88148623
30Abnormality of the preputium (HP:0100587)2.82168903
31Hypertensive crisis (HP:0100735)2.81257276
32Breast hypoplasia (HP:0003187)2.78807462
33Hypoparathyroidism (HP:0000829)2.78600553
34Acute myeloid leukemia (HP:0004808)2.78580234
35Tinnitus (HP:0000360)2.74117571
36Abnormality of the tricuspid valve (HP:0001702)2.72603720
37Increased nuchal translucency (HP:0010880)2.69503738
38Abnormality of oral frenula (HP:0000190)2.68929653
39Macrocytic anemia (HP:0001972)2.55097956
40Abnormality of cochlea (HP:0000375)2.52668680
41Conjunctival hamartoma (HP:0100780)2.52242314
42Overlapping toe (HP:0001845)2.51782631
43Aplasia/Hypoplasia of the earlobes (HP:0009906)2.44596257
44Duodenal stenosis (HP:0100867)2.38107116
45Small intestinal stenosis (HP:0012848)2.38107116
46Cholelithiasis (HP:0001081)2.36366015
47Meningioma (HP:0002858)2.35554128
48Myelodysplasia (HP:0002863)2.34970248
49Angiofibromas (HP:0010615)2.33562052
50Adenoma sebaceum (HP:0009720)2.33562052
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.32130928
52Ileus (HP:0002595)2.31674105
53Neuroendocrine neoplasm (HP:0100634)2.31400343
54Neoplasm of head and neck (HP:0012288)2.29824876
55Esophageal neoplasm (HP:0100751)2.29824876
56Abnormality of alanine metabolism (HP:0010916)2.25676392
57Hyperalaninemia (HP:0003348)2.25676392
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25676392
59Palpitations (HP:0001962)2.25293371
60Abnormality of sulfur amino acid metabolism (HP:0004339)2.21194447
61Abnormality of chromosome stability (HP:0003220)2.19900717
62Upper limb muscle weakness (HP:0003484)2.14115493
63Abnormality of the carotid arteries (HP:0005344)2.11805749
64Sandal gap (HP:0001852)2.11788454
65Abnormal gallbladder morphology (HP:0012437)2.07714176
66Septate vagina (HP:0001153)2.07587883
67Ureteral duplication (HP:0000073)2.07457944
68Flat cornea (HP:0007720)2.06191657
69Abnormality of cells of the erythroid lineage (HP:0012130)2.04936192
70Hyperbilirubinemia (HP:0002904)2.04431306
71Abnormal number of erythroid precursors (HP:0012131)2.04137939
72Morphological abnormality of the inner ear (HP:0011390)2.03595013
73Insomnia (HP:0100785)2.02176498
74Orthostatic hypotension (HP:0001278)1.99128180
75Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.98550715
76Atelectasis (HP:0100750)1.96225442
77Cafe-au-lait spot (HP:0000957)1.95883985
78Methylmalonic acidemia (HP:0002912)1.92768363
79Abnormality of DNA repair (HP:0003254)1.91723099
80Ectopic kidney (HP:0000086)1.85313625
81Nonimmune hydrops fetalis (HP:0001790)1.84688609
82Abnormality of methionine metabolism (HP:0010901)1.83554959
83Meckel diverticulum (HP:0002245)1.82889516
84Increased hepatocellular lipid droplets (HP:0006565)1.81648147
85Aplasia/Hypoplasia of the thymus (HP:0010515)1.81291460
86Selective tooth agenesis (HP:0001592)1.79421030
87Obsessive-compulsive behavior (HP:0000722)1.79381485
88Large hands (HP:0001176)1.75683378
89Abnormality of the duodenum (HP:0002246)1.75269997
90Abnormality of the gallbladder (HP:0005264)1.73967649
91Abnormality of the ileum (HP:0001549)1.72651098
92Blepharitis (HP:0000498)1.71022682
93Spastic paraparesis (HP:0002313)1.70296578
94Abnormality of the anterior horn cell (HP:0006802)1.69051432
95Degeneration of anterior horn cells (HP:0002398)1.69051432
96Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.67934206
97Choanal atresia (HP:0000453)1.66371026
98Cerebral hypomyelination (HP:0006808)1.65577564
99Respiratory difficulties (HP:0002880)1.64678212
100Cheekbone underdevelopment (HP:0010669)1.63913291

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.63239723
2TTK3.49575657
3KSR23.20950384
4TSSK63.12777323
5MST42.97224358
6CDC72.88007663
7PBK2.80477456
8MAP3K22.73805569
9SRPK12.61587208
10WEE12.51930024
11CLK12.46391377
12BUB12.44456124
13NME12.27423711
14MAP3K42.17214162
15RIPK42.17152065
16EEF2K2.15942537
17CDK122.15596469
18PLK42.08599806
19NEK22.02632415
20PDK21.99636321
21EIF2AK31.87806365
22BMPR21.78354842
23RAF11.70703662
24NTRK31.70358479
25NEK11.62174731
26BRSK21.56081660
27MAP3K81.46664613
28CCNB11.46306534
29TGFBR11.42112501
30SCYL21.35634697
31KSR11.34864108
32CHEK21.34150150
33PLK31.28336194
34ACVR1B1.25816735
35NME21.22962526
36MKNK11.22344994
37PASK1.12896305
38RPS6KB21.12505019
39PLK11.11741573
40ATR1.09322846
41MAP2K71.05698680
42ALK1.05085248
43STK41.04715250
44STK31.01783902
45CHEK11.01557344
46RET1.00478866
47MAP2K11.00347878
48ZAK0.93829769
49MKNK20.93087420
50WNK40.91791037
51TRPM70.90979217
52CDK10.86484295
53IRAK30.85272700
54CDK70.81811582
55MAP3K100.81599980
56BMX0.81316491
57ICK0.79729795
58AURKB0.76990097
59BRAF0.76438741
60BRSK10.75536455
61MST1R0.75189796
62ATM0.74888103
63TNIK0.73309220
64CDK20.69241874
65CDK80.67656178
66STK160.67543370
67MAP2K20.65683937
68AKT20.64398961
69MET0.61425475
70YES10.59490279
71CSNK2A20.59307187
72DMPK0.58735150
73AKT30.57523064
74BRD40.55939218
75CSNK1E0.55764525
76BMPR1B0.54091206
77DYRK30.48048786
78CSNK2A10.47960597
79MTOR0.45559318
80PAK20.45084565
81PRKCI0.42886845
82ERBB40.42589812
83PLK20.41701684
84MAP2K40.40538177
85JAK20.39801702
86MAP2K60.38017005
87FGFR30.34316630
88PAK40.32135775
89NEK60.31880065
90MAPK140.31600826
91MARK30.31389473
92CDK40.30952546
93PAK10.30937743
94ERN10.30253720
95AKT10.29982367
96PNCK0.29910555
97PRKDC0.29645516
98STK100.28886036
99CDK30.28787898
100GSK3B0.28606984

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.98623631
2DNA replication_Homo sapiens_hsa030303.95062721
3Mismatch repair_Homo sapiens_hsa034303.65020288
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.48555664
5One carbon pool by folate_Homo sapiens_hsa006703.29745457
6Homologous recombination_Homo sapiens_hsa034402.95687224
7Spliceosome_Homo sapiens_hsa030402.93782953
8Ribosome_Homo sapiens_hsa030102.90280939
9RNA transport_Homo sapiens_hsa030132.88411413
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.77386519
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.54948002
12Nucleotide excision repair_Homo sapiens_hsa034202.53446320
13Cell cycle_Homo sapiens_hsa041102.40917698
14Basal transcription factors_Homo sapiens_hsa030222.34550220
15Non-homologous end-joining_Homo sapiens_hsa034502.26008783
16RNA polymerase_Homo sapiens_hsa030202.21348499
17Proteasome_Homo sapiens_hsa030502.10298782
18Fanconi anemia pathway_Homo sapiens_hsa034602.01133418
19RNA degradation_Homo sapiens_hsa030181.82708654
20mRNA surveillance pathway_Homo sapiens_hsa030151.81073255
21Base excision repair_Homo sapiens_hsa034101.79239831
22Pyruvate metabolism_Homo sapiens_hsa006201.52966418
23Pyrimidine metabolism_Homo sapiens_hsa002401.46110769
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.40052803
25Protein export_Homo sapiens_hsa030601.38352900
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.36078649
27Oxidative phosphorylation_Homo sapiens_hsa001901.33540766
28Carbon metabolism_Homo sapiens_hsa012001.32775526
29Parkinsons disease_Homo sapiens_hsa050121.29199555
30Biosynthesis of amino acids_Homo sapiens_hsa012301.26699728
31Selenocompound metabolism_Homo sapiens_hsa004501.25888441
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.24330838
33Thyroid cancer_Homo sapiens_hsa052161.23141426
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18298314
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15818003
36Purine metabolism_Homo sapiens_hsa002301.10509110
37Steroid biosynthesis_Homo sapiens_hsa001001.10280597
38Huntingtons disease_Homo sapiens_hsa050161.07870046
39Oocyte meiosis_Homo sapiens_hsa041140.95688804
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89345230
41Fructose and mannose metabolism_Homo sapiens_hsa000510.88833013
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88314715
43Chronic myeloid leukemia_Homo sapiens_hsa052200.87128367
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78507890
45Propanoate metabolism_Homo sapiens_hsa006400.77694200
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75439358
47N-Glycan biosynthesis_Homo sapiens_hsa005100.69865110
48Alzheimers disease_Homo sapiens_hsa050100.67958320
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67511226
50Pancreatic cancer_Homo sapiens_hsa052120.67192705
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64266775
52Acute myeloid leukemia_Homo sapiens_hsa052210.62565525
53Viral carcinogenesis_Homo sapiens_hsa052030.62334501
54Prion diseases_Homo sapiens_hsa050200.61777692
55Olfactory transduction_Homo sapiens_hsa047400.61458730
56mTOR signaling pathway_Homo sapiens_hsa041500.60621519
57Epstein-Barr virus infection_Homo sapiens_hsa051690.60512047
58Bladder cancer_Homo sapiens_hsa052190.59924725
59ErbB signaling pathway_Homo sapiens_hsa040120.57985705
60Type II diabetes mellitus_Homo sapiens_hsa049300.56749225
61Nitrogen metabolism_Homo sapiens_hsa009100.55301753
62Pentose phosphate pathway_Homo sapiens_hsa000300.55284556
63Arginine biosynthesis_Homo sapiens_hsa002200.54913207
64Renal cell carcinoma_Homo sapiens_hsa052110.54171440
65Folate biosynthesis_Homo sapiens_hsa007900.53843526
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53576636
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.50943520
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.47260573
69MicroRNAs in cancer_Homo sapiens_hsa052060.45103836
70VEGF signaling pathway_Homo sapiens_hsa043700.44552196
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.43619258
72Non-small cell lung cancer_Homo sapiens_hsa052230.40762161
73Metabolic pathways_Homo sapiens_hsa011000.38247915
74Sulfur relay system_Homo sapiens_hsa041220.36399149
75Other glycan degradation_Homo sapiens_hsa005110.34453347
76Colorectal cancer_Homo sapiens_hsa052100.32903001
77HIF-1 signaling pathway_Homo sapiens_hsa040660.31679567
78Glutathione metabolism_Homo sapiens_hsa004800.31498176
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24126185
80p53 signaling pathway_Homo sapiens_hsa041150.24021009
81Insulin signaling pathway_Homo sapiens_hsa049100.24000224
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22294738
83Hepatitis B_Homo sapiens_hsa051610.22220150
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.21589921
85Vitamin B6 metabolism_Homo sapiens_hsa007500.20057022
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.18941626
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.17036212
88Cardiac muscle contraction_Homo sapiens_hsa042600.14652177
89Butanoate metabolism_Homo sapiens_hsa006500.14442095
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13619765
91Glioma_Homo sapiens_hsa052140.13108338
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13041497
93Small cell lung cancer_Homo sapiens_hsa052220.12943869
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.12011390
95Melanoma_Homo sapiens_hsa052180.11607614
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.10696455
97Adherens junction_Homo sapiens_hsa045200.10461840
98Prostate cancer_Homo sapiens_hsa052150.10336209
99Lysine degradation_Homo sapiens_hsa003100.10274148
100Prolactin signaling pathway_Homo sapiens_hsa049170.09744623

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