MAGEB10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the B subfamily of the melanoma associated antigen protein family. The encoded protein is specifically expressed in testis and tumor cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fucose catabolic process (GO:0019317)4.60575459
2L-fucose metabolic process (GO:0042354)4.60575459
3L-fucose catabolic process (GO:0042355)4.60575459
4DNA deamination (GO:0045006)4.52003409
5piRNA metabolic process (GO:0034587)4.49881168
6behavioral response to nicotine (GO:0035095)4.46405848
7phosphatidylinositol acyl-chain remodeling (GO:0036149)4.00855641
8detection of light stimulus involved in sensory perception (GO:0050962)3.77971795
9detection of light stimulus involved in visual perception (GO:0050908)3.77971795
10phosphatidylserine acyl-chain remodeling (GO:0036150)3.73045921
11protein polyglutamylation (GO:0018095)3.69812383
12response to pheromone (GO:0019236)3.66340555
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.57084951
14DNA methylation involved in gamete generation (GO:0043046)3.50978256
15water-soluble vitamin biosynthetic process (GO:0042364)3.46616216
16tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.44238593
17RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.44238593
18regulation of nuclear cell cycle DNA replication (GO:0033262)3.41802241
19cellular response to ATP (GO:0071318)3.39781386
20negative regulation of telomere maintenance (GO:0032205)3.37107127
21indole-containing compound catabolic process (GO:0042436)3.35728183
22indolalkylamine catabolic process (GO:0046218)3.35728183
23tryptophan catabolic process (GO:0006569)3.35728183
24preassembly of GPI anchor in ER membrane (GO:0016254)3.31323285
25kynurenine metabolic process (GO:0070189)3.30752545
26pyrimidine nucleobase catabolic process (GO:0006208)3.29380986
27detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.29014508
28cilium morphogenesis (GO:0060271)3.23391481
29indolalkylamine metabolic process (GO:0006586)3.21626823
30phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.19152964
31regulation of meiosis I (GO:0060631)3.18047795
32platelet dense granule organization (GO:0060155)3.16346249
33regulation of cilium movement (GO:0003352)3.15478499
34protein complex biogenesis (GO:0070271)3.14237349
35S-adenosylmethionine metabolic process (GO:0046500)3.12822065
36L-methionine salvage (GO:0071267)3.11524306
37L-methionine biosynthetic process (GO:0071265)3.11524306
38amino acid salvage (GO:0043102)3.11524306
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.07934449
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.07934449
41NADH dehydrogenase complex assembly (GO:0010257)3.07934449
42respiratory chain complex IV assembly (GO:0008535)3.07008911
43cornea development in camera-type eye (GO:0061303)3.06706973
44axoneme assembly (GO:0035082)3.05640860
45epithelial cilium movement (GO:0003351)3.03937840
46protein-cofactor linkage (GO:0018065)3.01285469
47auditory receptor cell stereocilium organization (GO:0060088)3.00930540
48ATP synthesis coupled proton transport (GO:0015986)3.00557122
49energy coupled proton transport, down electrochemical gradient (GO:0015985)3.00557122
50cellular ketone body metabolic process (GO:0046950)2.97689222
51nucleobase catabolic process (GO:0046113)2.97376775
52tryptophan metabolic process (GO:0006568)2.94047430
53RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.93020518
54mitochondrial respiratory chain complex assembly (GO:0033108)2.92655809
55protein neddylation (GO:0045116)2.92158458
56mannosylation (GO:0097502)2.91774148
57retinal cone cell development (GO:0046549)2.84101098
58mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.78541505
59photoreceptor cell maintenance (GO:0045494)2.78119873
60establishment of protein localization to mitochondrial membrane (GO:0090151)2.77726751
61photoreceptor cell development (GO:0042461)2.76768905
62ketone body metabolic process (GO:1902224)2.76585512
63nonmotile primary cilium assembly (GO:0035058)2.76570735
64positive regulation of protein homodimerization activity (GO:0090073)2.71074024
65phosphatidylcholine acyl-chain remodeling (GO:0036151)2.67848228
66tRNA processing (GO:0008033)2.67541552
67L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.64110364
68somite development (GO:0061053)2.63724147
69cilium or flagellum-dependent cell motility (GO:0001539)2.63465742
70multicellular organism reproduction (GO:0032504)2.63424219
71cytochrome complex assembly (GO:0017004)2.63215907
72nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.63045093
73seminiferous tubule development (GO:0072520)2.62658244
74amine catabolic process (GO:0009310)2.61125766
75cellular biogenic amine catabolic process (GO:0042402)2.61125766
76exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.60636312
77negative regulation of mast cell activation (GO:0033004)2.60244860
78kidney morphogenesis (GO:0060993)2.54197747
79cAMP catabolic process (GO:0006198)2.53945159
80tRNA modification (GO:0006400)2.51378153
81cilium movement (GO:0003341)2.51095651
82positive regulation of fatty acid transport (GO:2000193)2.50807879
83reciprocal meiotic recombination (GO:0007131)2.50051067
84reciprocal DNA recombination (GO:0035825)2.50051067
85cytidine metabolic process (GO:0046087)2.49691664
86cytidine catabolic process (GO:0006216)2.49691664
87cytidine deamination (GO:0009972)2.49691664
88GPI anchor metabolic process (GO:0006505)2.49678571
89cilium organization (GO:0044782)2.47941681
90inner ear receptor stereocilium organization (GO:0060122)2.47731996
91cyclic nucleotide catabolic process (GO:0009214)2.46511400
92C-terminal protein amino acid modification (GO:0018410)2.45449560
93regulation of rhodopsin mediated signaling pathway (GO:0022400)2.44610475
94termination of RNA polymerase III transcription (GO:0006386)2.41503685
95transcription elongation from RNA polymerase III promoter (GO:0006385)2.41503685
96male meiosis I (GO:0007141)2.41468353
97C-terminal protein lipidation (GO:0006501)2.41368662
98recombinational repair (GO:0000725)2.41321549
99cilium assembly (GO:0042384)2.40437380
100synaptic transmission, cholinergic (GO:0007271)2.40061366

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.20987621
2VDR_22108803_ChIP-Seq_LS180_Human3.37389800
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.91708234
4IGF1R_20145208_ChIP-Seq_DFB_Human2.75522220
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.48158522
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47988216
7GBX2_23144817_ChIP-Seq_PC3_Human2.44346201
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.44066985
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33909066
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27726045
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.24120416
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21794024
13EZH2_22144423_ChIP-Seq_EOC_Human2.11583022
14FUS_26573619_Chip-Seq_HEK293_Human2.11273301
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04240957
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00257060
17EWS_26573619_Chip-Seq_HEK293_Human1.94813163
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94270818
19TP53_22573176_ChIP-Seq_HFKS_Human1.89978355
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.89598230
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.89078464
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.88322341
23P300_19829295_ChIP-Seq_ESCs_Human1.82376212
24IRF1_19129219_ChIP-ChIP_H3396_Human1.79396635
25ER_23166858_ChIP-Seq_MCF-7_Human1.64518204
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63039470
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58891496
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.56773418
29TAF15_26573619_Chip-Seq_HEK293_Human1.55961007
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.53363526
31IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52921462
32CBP_20019798_ChIP-Seq_JUKART_Human1.52921462
33BCAT_22108803_ChIP-Seq_LS180_Human1.50054724
34VDR_23849224_ChIP-Seq_CD4+_Human1.49526651
35MYC_18940864_ChIP-ChIP_HL60_Human1.44918735
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43775735
37ELK1_19687146_ChIP-ChIP_HELA_Human1.40515062
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40429783
39GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37307357
40GATA3_21878914_ChIP-Seq_MCF-7_Human1.36808186
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35951545
42TCF4_23295773_ChIP-Seq_U87_Human1.35247800
43ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33311505
44FOXA1_25329375_ChIP-Seq_VCAP_Human1.33003361
45FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33003361
46SOX2_19829295_ChIP-Seq_ESCs_Human1.32565006
47NANOG_19829295_ChIP-Seq_ESCs_Human1.32565006
48SMAD4_21799915_ChIP-Seq_A2780_Human1.32089089
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31622891
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31187743
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30807224
52REST_21632747_ChIP-Seq_MESCs_Mouse1.30385561
53KLF5_20875108_ChIP-Seq_MESCs_Mouse1.30267702
54AR_25329375_ChIP-Seq_VCAP_Human1.30171765
55STAT3_23295773_ChIP-Seq_U87_Human1.27007657
56TCF4_22108803_ChIP-Seq_LS180_Human1.26284666
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24802848
58AR_20517297_ChIP-Seq_VCAP_Human1.24568990
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24250618
60* HOXB7_26014856_ChIP-Seq_BT474_Human1.23947807
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.23524870
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.20057536
63NCOR_22424771_ChIP-Seq_293T_Human1.19793776
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19241826
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19149218
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19149218
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17170611
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.15804621
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15299083
70CDX2_22108803_ChIP-Seq_LS180_Human1.14165751
71SMAD4_21741376_ChIP-Seq_EPCs_Human1.13234517
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13122853
73MYC_19829295_ChIP-Seq_ESCs_Human1.12446384
74AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12363027
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11748087
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10160418
77FOXH1_21741376_ChIP-Seq_EPCs_Human1.10153136
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09932561
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09396865
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08635209
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.08233185
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08027444
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.05976242
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05887815
85CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05248812
86ERA_21632823_ChIP-Seq_H3396_Human1.04400496
87RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03878101
88P53_21459846_ChIP-Seq_SAOS-2_Human1.03055833
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.03045050
90RUNX2_22187159_ChIP-Seq_PCA_Human1.02544447
91* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02141719
92NANOG_20526341_ChIP-Seq_ESCs_Human1.01753125
93EZH2_27294783_Chip-Seq_NPCs_Mouse1.01741664
94FOXP3_21729870_ChIP-Seq_TREG_Human0.99531646
95CBX2_27304074_Chip-Seq_ESCs_Mouse0.98889441
96REST_18959480_ChIP-ChIP_MESCs_Mouse0.98413783
97FLI1_21867929_ChIP-Seq_TH2_Mouse0.97555051
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97290352
99RNF2_27304074_Chip-Seq_NSC_Mouse0.97144408
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96233827

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity3.05274580
2MP0008877_abnormal_DNA_methylation2.92258580
3MP0003195_calcinosis2.71692846
4MP0002138_abnormal_hepatobiliary_system2.66301813
5MP0005551_abnormal_eye_electrophysiolog2.55408656
6MP0002102_abnormal_ear_morphology2.35555410
7MP0000569_abnormal_digit_pigmentation2.35303387
8MP0002837_dystrophic_cardiac_calcinosis2.34550069
9MP0002653_abnormal_ependyma_morphology2.26282499
10MP0001968_abnormal_touch/_nociception2.20122199
11MP0003646_muscle_fatigue2.15247665
12MP0008872_abnormal_physiological_respon2.12672284
13MP0001984_abnormal_olfaction1.95552233
14MP0003787_abnormal_imprinting1.95256184
15MP0008875_abnormal_xenobiotic_pharmacok1.94345731
16MP0003011_delayed_dark_adaptation1.91154758
17MP0005075_abnormal_melanosome_morpholog1.90459469
18MP0005645_abnormal_hypothalamus_physiol1.90346756
19MP0005084_abnormal_gallbladder_morpholo1.89535221
20MP0000372_irregular_coat_pigmentation1.84870794
21MP0009046_muscle_twitch1.82100036
22MP0009745_abnormal_behavioral_response1.78645980
23MP0004043_abnormal_pH_regulation1.78414763
24MP0002876_abnormal_thyroid_physiology1.77063187
25MP0005253_abnormal_eye_physiology1.71613985
26MP0006072_abnormal_retinal_apoptosis1.71380303
27MP0005646_abnormal_pituitary_gland1.71057277
28MP0002736_abnormal_nociception_after1.71035326
29MP0006292_abnormal_olfactory_placode1.68898764
30MP0001486_abnormal_startle_reflex1.66814686
31MP0000427_abnormal_hair_cycle1.58244521
32MP0000631_abnormal_neuroendocrine_gland1.53139250
33MP0004885_abnormal_endolymph1.52891035
34MP0006276_abnormal_autonomic_nervous1.52626035
35MP0002638_abnormal_pupillary_reflex1.48882200
36MP0002272_abnormal_nervous_system1.47427449
37MP0003880_abnormal_central_pattern1.47146708
38MP0005360_urolithiasis1.42462660
39MP0002938_white_spotting1.42428648
40MP0005174_abnormal_tail_pigmentation1.37197280
41MP0005379_endocrine/exocrine_gland_phen1.32205404
42MP0004145_abnormal_muscle_electrophysio1.29159224
43MP0001529_abnormal_vocalization1.28438560
44MP0001501_abnormal_sleep_pattern1.26955490
45MP0004147_increased_porphyrin_level1.22618936
46MP0004142_abnormal_muscle_tone1.19886682
47MP0002557_abnormal_social/conspecific_i1.19863687
48MP0004133_heterotaxia1.19304985
49MP0003136_yellow_coat_color1.18533532
50MP0002163_abnormal_gland_morphology1.18196677
51MP0005423_abnormal_somatic_nervous1.16822083
52MP0001485_abnormal_pinna_reflex1.14594374
53MP0005410_abnormal_fertilization1.14576680
54MP0002572_abnormal_emotion/affect_behav1.14067875
55MP0002064_seizures1.12537131
56MP0003122_maternal_imprinting1.11443199
57MP0004924_abnormal_behavior1.11247746
58MP0005386_behavior/neurological_phenoty1.11247746
59MP0001502_abnormal_circadian_rhythm1.09391885
60MP0008775_abnormal_heart_ventricle1.08480054
61MP0001970_abnormal_pain_threshold1.08073810
62MP0002733_abnormal_thermal_nociception1.07536508
63MP0000778_abnormal_nervous_system1.06782407
64MP0008789_abnormal_olfactory_epithelium1.05396227
65MP0005195_abnormal_posterior_eye1.01907456
66MP0002928_abnormal_bile_duct1.01415506
67MP0001905_abnormal_dopamine_level1.00515642
68MP0008995_early_reproductive_senescence0.97416971
69MP0003121_genomic_imprinting0.97226968
70MP0002735_abnormal_chemical_nociception0.96446441
71MP0006054_spinal_hemorrhage0.95379130
72MP0002752_abnormal_somatic_nervous0.95262789
73MP0002067_abnormal_sensory_capabilities0.95223961
74MP0002095_abnormal_skin_pigmentation0.94964542
75MP0004742_abnormal_vestibular_system0.94744634
76MP0001188_hyperpigmentation0.92867762
77MP0003635_abnormal_synaptic_transmissio0.92212329
78MP0002909_abnormal_adrenal_gland0.91528631
79MP0003718_maternal_effect0.90935714
80MP0002822_catalepsy0.90595171
81MP0005671_abnormal_response_to0.90566279
82MP0010386_abnormal_urinary_bladder0.88398025
83MP0002063_abnormal_learning/memory/cond0.86801997
84MP0002184_abnormal_innervation0.85136291
85MP0005167_abnormal_blood-brain_barrier0.85119065
86MP0001764_abnormal_homeostasis0.83894104
87MP0002751_abnormal_autonomic_nervous0.83222915
88MP0003698_abnormal_male_reproductive0.81343331
89MP0002229_neurodegeneration0.80958061
90MP0002693_abnormal_pancreas_physiology0.80762139
91MP0005332_abnormal_amino_acid0.80550911
92MP0003252_abnormal_bile_duct0.79840860
93MP0001324_abnormal_eye_pigmentation0.79131354
94MP0000647_abnormal_sebaceous_gland0.78705752
95MP0005377_hearing/vestibular/ear_phenot0.78642213
96MP0003878_abnormal_ear_physiology0.78642213
97MP0005085_abnormal_gallbladder_physiolo0.77534040
98MP0005171_absent_coat_pigmentation0.75988300
99MP0004215_abnormal_myocardial_fiber0.75287496
100MP0003137_abnormal_impulse_conducting0.72998385

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.42473822
2Pancreatic fibrosis (HP:0100732)4.27514602
3Abnormality of midbrain morphology (HP:0002418)4.26379849
4Molar tooth sign on MRI (HP:0002419)4.26379849
5Congenital stationary night blindness (HP:0007642)4.05747227
6Nephronophthisis (HP:0000090)3.68010458
7True hermaphroditism (HP:0010459)3.60079425
8Chronic hepatic failure (HP:0100626)3.57186464
9Type II lissencephaly (HP:0007260)3.38349240
10Abnormality of the renal cortex (HP:0011035)3.35086287
11Abnormality of the renal medulla (HP:0100957)3.21805328
12Abnormal biliary tract physiology (HP:0012439)2.99670969
13Bile duct proliferation (HP:0001408)2.99670969
14Medial flaring of the eyebrow (HP:0010747)2.86167153
15Renal cortical cysts (HP:0000803)2.79178456
16Attenuation of retinal blood vessels (HP:0007843)2.75519466
17Acute necrotizing encephalopathy (HP:0006965)2.73232163
18Abolished electroretinogram (ERG) (HP:0000550)2.68831881
19Hyperventilation (HP:0002883)2.67577002
20Cystic liver disease (HP:0006706)2.65287262
21Abnormal rod and cone electroretinograms (HP:0008323)2.61808976
22Tubular atrophy (HP:0000092)2.55286203
23Acute encephalopathy (HP:0006846)2.53663037
24Decreased central vision (HP:0007663)2.52981922
25Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.48929748
263-Methylglutaconic aciduria (HP:0003535)2.48202723
27Abnormal drinking behavior (HP:0030082)2.42777447
28Polydipsia (HP:0001959)2.42777447
29Cerebellar dysplasia (HP:0007033)2.40639454
30Pendular nystagmus (HP:0012043)2.38040162
31Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.37686299
32Progressive macrocephaly (HP:0004481)2.37340637
33Methylmalonic aciduria (HP:0012120)2.36104612
34Abnormal mitochondria in muscle tissue (HP:0008316)2.35094008
35Decreased electroretinogram (ERG) amplitude (HP:0000654)2.35074534
36Mitochondrial inheritance (HP:0001427)2.34163722
37Optic nerve hypoplasia (HP:0000609)2.31201955
38Sclerocornea (HP:0000647)2.24606489
39Agnosia (HP:0010524)2.24289241
40Increased CSF lactate (HP:0002490)2.23830440
41Gait imbalance (HP:0002141)2.23108500
42Aplasia/Hypoplasia of the fovea (HP:0008060)2.21975136
43Hypoplasia of the fovea (HP:0007750)2.21975136
44Progressive inability to walk (HP:0002505)2.21651205
45Methylmalonic acidemia (HP:0002912)2.18140135
46Optic disc pallor (HP:0000543)2.17881245
47Polyphagia (HP:0002591)2.15413645
48Inability to walk (HP:0002540)2.13944134
49Aplasia/hypoplasia of the uterus (HP:0008684)2.13855632
50Aplasia/Hypoplasia of the tongue (HP:0010295)2.11561263
51Congenital hepatic fibrosis (HP:0002612)2.10079134
52Congenital primary aphakia (HP:0007707)2.09779529
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.09712013
54Aplasia/Hypoplasia of the spleen (HP:0010451)2.05815846
55Postaxial foot polydactyly (HP:0001830)2.05791028
56Severe muscular hypotonia (HP:0006829)2.05786462
57Anencephaly (HP:0002323)2.03486480
58Ketosis (HP:0001946)2.03154399
59Pachygyria (HP:0001302)2.01166611
60Gaze-evoked nystagmus (HP:0000640)2.00874419
61Retinal dysplasia (HP:0007973)2.00532110
62Lipid accumulation in hepatocytes (HP:0006561)1.99756264
63Delayed CNS myelination (HP:0002188)1.97739172
64Lissencephaly (HP:0001339)1.97218160
65Postaxial hand polydactyly (HP:0001162)1.95756968
66Abnormality of macular pigmentation (HP:0008002)1.95085723
67Rib fusion (HP:0000902)1.94931633
68Hypoproteinemia (HP:0003075)1.94786767
69Absent rod-and cone-mediated responses on ERG (HP:0007688)1.92908710
70Oculomotor apraxia (HP:0000657)1.92446846
71Asplenia (HP:0001746)1.91962475
72Nephrogenic diabetes insipidus (HP:0009806)1.91933227
73Septo-optic dysplasia (HP:0100842)1.86924453
74Broad-based gait (HP:0002136)1.86865597
75Chorioretinal atrophy (HP:0000533)1.86075498
76Polyuria (HP:0000103)1.85079794
77Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.83102829
78Cerebral edema (HP:0002181)1.82906175
79Oligodactyly (hands) (HP:0001180)1.82555959
80Hemiparesis (HP:0001269)1.82500513
81Progressive cerebellar ataxia (HP:0002073)1.82070864
82Increased hepatocellular lipid droplets (HP:0006565)1.81327731
83Abnormality of the labia minora (HP:0012880)1.80955972
84Short tibia (HP:0005736)1.79765257
85Furrowed tongue (HP:0000221)1.79728299
86Decreased circulating renin level (HP:0003351)1.78949737
87Thyroiditis (HP:0100646)1.78916384
88Hepatic necrosis (HP:0002605)1.78847621
89Absent thumb (HP:0009777)1.78004603
90Increased serum lactate (HP:0002151)1.77618178
91Genital tract atresia (HP:0001827)1.76939125
92Genetic anticipation (HP:0003743)1.76555094
93Bony spicule pigmentary retinopathy (HP:0007737)1.76003217
94Keratoconus (HP:0000563)1.75666737
95Increased corneal curvature (HP:0100692)1.75666737
96Narrow forehead (HP:0000341)1.75588053
97Male pseudohermaphroditism (HP:0000037)1.74313855
98Occipital encephalocele (HP:0002085)1.73812782
99Stomach cancer (HP:0012126)1.72782984
100Hypoplasia of the uterus (HP:0000013)1.71965800

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.50571545
2MAP4K23.57410101
3ADRBK23.15517104
4WNK32.81655979
5WNK42.79635170
6ZAK2.79128536
7BMPR1B2.75401263
8NUAK12.41778187
9PINK12.37552116
10GRK12.29276039
11MAP3K42.13855965
12STK162.08664903
13BCKDK2.03330375
14INSRR1.92878659
15TRIM281.89110368
16MAPK131.84251227
17CASK1.81968486
18DYRK21.77496376
19TAOK31.60832805
20TLK11.53545875
21MAP2K61.49354600
22MARK11.48275215
23CDK191.47453672
24OXSR11.44756593
25MAP2K71.34154929
26MST41.31759896
27STK391.29480664
28TXK1.29278482
29DAPK21.29147211
30PHKG11.24014902
31PHKG21.24014902
32CSNK1G31.15752487
33ACVR1B1.15221187
34CSNK1A1L1.11888688
35CSNK1G11.08813515
36PLK21.08610305
37EIF2AK11.08268641
38CSNK1G21.04885865
39STK38L1.01898924
40FLT30.96065918
41TNIK0.94155037
42PRKCE0.94045478
43MAPKAPK30.93724265
44PAK30.92087062
45TIE10.84546535
46ADRBK10.83495730
47MKNK20.82572146
48EIF2AK30.73608788
49PTK2B0.73490549
50TEC0.71102790
51PIK3CG0.70334630
52PRKCG0.70304016
53TGFBR10.69326791
54DYRK30.67591685
55MAPKAPK50.66167130
56NTRK30.65298453
57DYRK1A0.63825890
58BCR0.63295288
59PNCK0.63033198
60PRKCQ0.62911307
61NME10.60339734
62PRKCI0.59603491
63NTRK20.58370035
64LATS10.55864566
65IKBKB0.51281123
66ITK0.50071211
67SYK0.48237736
68VRK10.47996761
69AKT30.46085552
70CSNK1A10.45345481
71PRKACA0.44890198
72MAP2K40.43618695
73MUSK0.43444656
74FER0.43232565
75ERBB30.42941006
76CAMK10.42924674
77BRSK20.42501424
78PLK30.42363217
79MARK30.41246487
80TNK20.40456575
81CAMK2A0.39961741
82STK30.39104101
83CAMKK20.38588786
84RPS6KA40.38247443
85RPS6KA50.38064440
86PLK40.36934075
87CSNK1D0.36489685
88PRKG10.34926661
89STK110.34510534
90EPHA30.33569720
91EPHA40.32851244
92PRKCA0.32475122
93MATK0.31809667
94GRK70.27578096
95CAMK2D0.27476237
96PRKAA10.27368458
97PKN10.27309400
98OBSCN0.27206675
99KIT0.27072742
100MKNK10.26946488

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.29481458
2Linoleic acid metabolism_Homo sapiens_hsa005913.14035886
3Phototransduction_Homo sapiens_hsa047442.87868959
4Oxidative phosphorylation_Homo sapiens_hsa001902.58244036
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.42579561
6RNA polymerase_Homo sapiens_hsa030202.37654973
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.32202706
8Protein export_Homo sapiens_hsa030602.26229720
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.19149206
10Ether lipid metabolism_Homo sapiens_hsa005652.08098564
11Nitrogen metabolism_Homo sapiens_hsa009102.07820833
12Parkinsons disease_Homo sapiens_hsa050122.05481849
13Butanoate metabolism_Homo sapiens_hsa006501.91478687
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.85538261
15Propanoate metabolism_Homo sapiens_hsa006401.74366515
16Nicotine addiction_Homo sapiens_hsa050331.71775757
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70715450
18Basal transcription factors_Homo sapiens_hsa030221.64455950
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64201077
20Caffeine metabolism_Homo sapiens_hsa002321.63214258
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59658310
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.55022366
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.46563078
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.46234795
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41942660
26Asthma_Homo sapiens_hsa053101.36428516
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33766995
28RNA degradation_Homo sapiens_hsa030181.33316425
29Regulation of autophagy_Homo sapiens_hsa041401.32569724
30Huntingtons disease_Homo sapiens_hsa050161.31836324
31Alzheimers disease_Homo sapiens_hsa050101.28786963
32Olfactory transduction_Homo sapiens_hsa047401.28559857
33Autoimmune thyroid disease_Homo sapiens_hsa053201.27535613
34Tryptophan metabolism_Homo sapiens_hsa003801.24358293
35Allograft rejection_Homo sapiens_hsa053301.24029980
36Fanconi anemia pathway_Homo sapiens_hsa034601.22511009
37Homologous recombination_Homo sapiens_hsa034401.22454487
38Morphine addiction_Homo sapiens_hsa050321.22057013
39Proteasome_Homo sapiens_hsa030501.20398113
40Cardiac muscle contraction_Homo sapiens_hsa042601.20119838
41Arachidonic acid metabolism_Homo sapiens_hsa005901.19444434
42Taste transduction_Homo sapiens_hsa047421.15554282
43Sulfur relay system_Homo sapiens_hsa041221.14845345
44Peroxisome_Homo sapiens_hsa041461.14307476
45Sulfur metabolism_Homo sapiens_hsa009201.13652064
46Type I diabetes mellitus_Homo sapiens_hsa049401.11213557
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.10354727
48Selenocompound metabolism_Homo sapiens_hsa004501.07586783
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07307273
50Graft-versus-host disease_Homo sapiens_hsa053321.05790063
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.04224274
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01914240
53Primary immunodeficiency_Homo sapiens_hsa053401.01144979
54Chemical carcinogenesis_Homo sapiens_hsa052041.00393328
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96418982
56Collecting duct acid secretion_Homo sapiens_hsa049660.93728769
57Purine metabolism_Homo sapiens_hsa002300.91228563
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.85978450
59GABAergic synapse_Homo sapiens_hsa047270.85701021
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85501468
61One carbon pool by folate_Homo sapiens_hsa006700.84026522
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82282151
63Retinol metabolism_Homo sapiens_hsa008300.81505983
64Circadian entrainment_Homo sapiens_hsa047130.79180351
65Insulin secretion_Homo sapiens_hsa049110.77658570
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76358104
67Steroid biosynthesis_Homo sapiens_hsa001000.75109210
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73952240
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73830086
70Glutamatergic synapse_Homo sapiens_hsa047240.69248425
71Serotonergic synapse_Homo sapiens_hsa047260.68816558
72Metabolic pathways_Homo sapiens_hsa011000.66117447
73Circadian rhythm_Homo sapiens_hsa047100.65650961
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63188873
75beta-Alanine metabolism_Homo sapiens_hsa004100.61447567
76Ovarian steroidogenesis_Homo sapiens_hsa049130.61297943
77Salivary secretion_Homo sapiens_hsa049700.58356798
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56669724
79RNA transport_Homo sapiens_hsa030130.56584015
80Pyrimidine metabolism_Homo sapiens_hsa002400.56469208
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51906301
82Rheumatoid arthritis_Homo sapiens_hsa053230.49605961
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48361556
84Dorso-ventral axis formation_Homo sapiens_hsa043200.48129948
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.46643629
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45583984
87Non-homologous end-joining_Homo sapiens_hsa034500.45054357
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44685796
89Mineral absorption_Homo sapiens_hsa049780.44652087
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43444926
91ABC transporters_Homo sapiens_hsa020100.41535157
92mRNA surveillance pathway_Homo sapiens_hsa030150.39915042
93Fat digestion and absorption_Homo sapiens_hsa049750.39007711
94Ribosome_Homo sapiens_hsa030100.38314019
95Hedgehog signaling pathway_Homo sapiens_hsa043400.36203029
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35561880
97Glycerolipid metabolism_Homo sapiens_hsa005610.35480781
98Calcium signaling pathway_Homo sapiens_hsa040200.34722990
99Dopaminergic synapse_Homo sapiens_hsa047280.34560896
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30783761

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