MAGEB18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1superoxide anion generation (GO:0042554)9.70455363
2regulation of activation of Janus kinase activity (GO:0010533)7.09186476
3cellular response to exogenous dsRNA (GO:0071360)6.77754842
4regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)6.59382808
5positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)6.59382808
6cellular response to interferon-beta (GO:0035458)6.27878815
7positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)6.22706473
8regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)5.85542180
9positive regulation of chemokine biosynthetic process (GO:0045080)5.77219615
10positive regulation of T cell mediated cytotoxicity (GO:0001916)5.13224545
11response to interferon-beta (GO:0035456)5.01552823
12regulation of chemokine biosynthetic process (GO:0045073)4.73250527
13positive regulation of alpha-beta T cell proliferation (GO:0046641)4.72881033
14positive regulation of interleukin-17 production (GO:0032740)4.64260110
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.63264534
16regulation of T cell mediated cytotoxicity (GO:0001914)4.62421715
17positive regulation of defense response to virus by host (GO:0002230)4.52368646
18regulation of memory T cell differentiation (GO:0043380)4.47143824
19positive regulation of T-helper 1 type immune response (GO:0002827)4.33320184
20response to peptidoglycan (GO:0032494)4.32786029
21glutamine family amino acid biosynthetic process (GO:0009084)4.25153240
22response to gravity (GO:0009629)4.22473039
23superoxide metabolic process (GO:0006801)4.09892699
24positive regulation of cAMP-mediated signaling (GO:0043950)4.06024434
25positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.01431820
26T cell migration (GO:0072678)3.95699657
27natural killer cell activation involved in immune response (GO:0002323)3.95616506
28negative regulation of T cell mediated immunity (GO:0002710)3.95242750
29positive regulation of heat generation (GO:0031652)3.90332689
30positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.89786029
31regulation of interleukin-17 production (GO:0032660)3.79117423
32negative regulation of type 2 immune response (GO:0002829)3.79042748
33cellular extravasation (GO:0045123)3.75355134
34regulation of isotype switching to IgG isotypes (GO:0048302)3.71641891
35leukocyte aggregation (GO:0070486)3.69176409
36regulation of alpha-beta T cell proliferation (GO:0046640)3.66052918
37regulation of defense response to virus by host (GO:0050691)3.62108341
38lipopolysaccharide-mediated signaling pathway (GO:0031663)3.61925668
39positive regulation of cellular amide metabolic process (GO:0034250)3.59509081
40regulation of fever generation (GO:0031620)3.57993242
41regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.57220899
42eosinophil chemotaxis (GO:0048245)3.56317630
43positive regulation of T-helper cell differentiation (GO:0045624)3.52317811
44regulation of T-helper 1 type immune response (GO:0002825)3.51806484
45positive regulation of macrophage differentiation (GO:0045651)3.47574129
46positive regulation of NF-kappaB import into nucleus (GO:0042346)3.46586721
47regulation of B cell receptor signaling pathway (GO:0050855)3.46344419
48temperature homeostasis (GO:0001659)3.45476271
49regulation of lymphocyte chemotaxis (GO:1901623)3.45418613
50positive regulation of lymphocyte migration (GO:2000403)3.44787961
51positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.38266024
52negative regulation of amino acid transport (GO:0051956)3.37840142
53homocysteine metabolic process (GO:0050667)3.34172169
54defense response to protozoan (GO:0042832)3.33541858
55negative regulation of viral genome replication (GO:0045071)3.29761757
56regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.25528123
57negative regulation of meiosis (GO:0045835)3.24716232
58regulation of T cell mediated immunity (GO:0002709)3.24574633
59regulation of heterotypic cell-cell adhesion (GO:0034114)3.22009613
60glutamine metabolic process (GO:0006541)3.19187512
61positive regulation of interleukin-1 beta secretion (GO:0050718)3.16941964
62negative regulation by host of viral transcription (GO:0043922)3.13286970
63positive regulation of cell killing (GO:0031343)3.13034228
64piRNA metabolic process (GO:0034587)3.12218851
65lymphocyte chemotaxis (GO:0048247)3.11721947
66eosinophil migration (GO:0072677)3.03810673
67positive regulation of macrophage cytokine production (GO:0060907)3.03640361
68hydrogen peroxide biosynthetic process (GO:0050665)3.02466144
69positive regulation of T cell mediated immunity (GO:0002711)2.98259543
70regulation of interleukin-2 biosynthetic process (GO:0045076)2.97524980
71regulation of chronic inflammatory response (GO:0002676)2.95851350
72regulation of leukocyte mediated cytotoxicity (GO:0001910)2.95162976
73negative regulation of cell killing (GO:0031342)2.95049302
74negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.95049302
75positive regulation of interleukin-10 production (GO:0032733)2.94319218
76positive regulation of interleukin-1 secretion (GO:0050716)2.91109169
77natural killer cell activation (GO:0030101)2.90211509
78positive regulation of interferon-gamma production (GO:0032729)2.89754960
79positive regulation of activated T cell proliferation (GO:0042104)2.87613711
80regulation of cell killing (GO:0031341)2.86703041
81positive regulation of interleukin-12 production (GO:0032735)2.85516818
82regulation of MHC class I biosynthetic process (GO:0045343)2.83779047
83positive regulation of nitric oxide biosynthetic process (GO:0045429)2.81322532
84kinetochore assembly (GO:0051382)2.80177969
85cellular response to interleukin-15 (GO:0071350)2.80160991
86negative regulation of interleukin-17 production (GO:0032700)2.78950043
87regulation of vitamin D biosynthetic process (GO:0060556)2.78158759
88positive regulation of chemokine production (GO:0032722)2.77699258
89regulation of cytokine secretion involved in immune response (GO:0002739)2.76118116
90regulation of interleukin-1 beta secretion (GO:0050706)2.75270195
91reactive oxygen species biosynthetic process (GO:1903409)2.74582821
92cellular response to dsRNA (GO:0071359)2.74238739
93positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.73325907
94regulation of T-helper cell differentiation (GO:0045622)2.72898678
95positive regulation of DNA biosynthetic process (GO:2000573)2.71947170
96positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.71335688
97regulation of vitamin metabolic process (GO:0030656)2.70540407
98B cell proliferation (GO:0042100)2.68852967
99regulation of heat generation (GO:0031650)2.68706513
100positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.67852723

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.42014086
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.78508406
3PCGF2_27294783_Chip-Seq_ESCs_Mouse3.70621813
4HTT_18923047_ChIP-ChIP_STHdh_Human3.49837820
5IGF1R_20145208_ChIP-Seq_DFB_Human3.13681173
6FLI1_27457419_Chip-Seq_LIVER_Mouse3.01010233
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.94866054
8SUZ12_27294783_Chip-Seq_NPCs_Mouse2.88181977
9NFE2_27457419_Chip-Seq_LIVER_Mouse2.71666879
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.71551470
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.65144310
12PCGF2_27294783_Chip-Seq_NPCs_Mouse2.52065463
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.49945260
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.44783230
15EZH2_27294783_Chip-Seq_NPCs_Mouse2.30517642
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.30196483
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.21258430
18GBX2_23144817_ChIP-Seq_PC3_Human2.07650107
19NMYC_18555785_Chip-Seq_ESCs_Mouse1.97778609
20POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.96096261
21TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96096261
22OCT4_21477851_ChIP-Seq_ESCs_Mouse1.94656894
23E2F1_18555785_Chip-Seq_ESCs_Mouse1.86467795
24EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.85504728
25SUZ12_18555785_Chip-Seq_ESCs_Mouse1.83381892
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83115887
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.81787753
28* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.80653814
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78730331
30STAT3_18555785_Chip-Seq_ESCs_Mouse1.78697342
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.73866640
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72375232
33P53_22387025_ChIP-Seq_ESCs_Mouse1.71984842
34PU1_27457419_Chip-Seq_LIVER_Mouse1.71848958
35OCT4_18555785_Chip-Seq_ESCs_Mouse1.71545548
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.70594837
37SOX2_18555785_Chip-Seq_ESCs_Mouse1.66485318
38RUNX1_27457419_Chip-Seq_LIVER_Mouse1.65652488
39P300_18555785_Chip-Seq_ESCs_Mouse1.64605027
40CRX_20693478_ChIP-Seq_RETINA_Mouse1.64481866
41VDR_24787735_ChIP-Seq_THP-1_Human1.63505902
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61173176
43RNF2_27304074_Chip-Seq_NSC_Mouse1.59825679
44TAL1_26923725_Chip-Seq_HPCs_Mouse1.59622345
45EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.58692228
46ZFX_18555785_Chip-Seq_ESCs_Mouse1.56484327
47TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.54783577
48CMYC_18555785_Chip-Seq_ESCs_Mouse1.52872832
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51922225
50CTCF_18555785_Chip-Seq_ESCs_Mouse1.51875984
51KLF4_18555785_Chip-Seq_ESCs_Mouse1.51750566
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.51114152
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49920836
54ESRRB_18555785_Chip-Seq_ESCs_Mouse1.49791611
55SMAD1_18555785_Chip-Seq_ESCs_Mouse1.48670705
56CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.48313932
57* CBX2_27304074_Chip-Seq_ESCs_Mouse1.47734386
58SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.45296214
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43618702
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37021220
61NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33326081
62* FUS_26573619_Chip-Seq_HEK293_Human1.31741561
63E2F7_22180533_ChIP-Seq_HELA_Human1.29499133
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.29379945
65STAT1_17558387_ChIP-Seq_HELA_Human1.29021281
66LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26139425
67CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22712467
68KAP1_22055183_ChIP-Seq_ESCs_Mouse1.21751503
69TP63_17297297_ChIP-ChIP_HaCaT_Human1.17883472
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17459822
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17414733
72CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16873907
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14172564
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12579466
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.10777018
76P300_19829295_ChIP-Seq_ESCs_Human1.09404244
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05924361
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05716325
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03184495
80KDM2B_26808549_Chip-Seq_REH_Human1.02785729
81RUNX_20019798_ChIP-Seq_JUKART_Human1.00494562
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00390453
83EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99801858
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99411868
85RNF2_27304074_Chip-Seq_ESCs_Mouse0.98385111
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.93980028
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92800670
88GATA3_26560356_Chip-Seq_TH2_Human0.91819572
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91545715
90EED_16625203_ChIP-ChIP_MESCs_Mouse0.91380233
91CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90389282
92STAT3_23295773_ChIP-Seq_U87_Human0.87579863
93ER_23166858_ChIP-Seq_MCF-7_Human0.87441389
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87112034
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85741836
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85416621
97EZH2_27294783_Chip-Seq_ESCs_Mouse0.85228205
98PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84391483
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84111951
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.84091804

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006082_CNS_inflammation5.56278024
2MP0009785_altered_susceptibility_to4.84554969
3MP0000569_abnormal_digit_pigmentation3.81946445
4MP0002148_abnormal_hypersensitivity_rea3.17534440
5MP0003724_increased_susceptibility_to3.12175415
6MP0005257_abnormal_intraocular_pressure3.09478488
7MP0001835_abnormal_antigen_presentation2.79613818
8MP0005025_abnormal_response_to2.78538311
9MP0009764_decreased_sensitivity_to2.62904423
10MP0002419_abnormal_innate_immunity2.57460025
11MP0005000_abnormal_immune_tolerance2.40694228
12MP0005671_abnormal_response_to2.38916053
13MP0003436_decreased_susceptibility_to2.27032304
14MP0002876_abnormal_thyroid_physiology2.09344291
15MP0002006_tumorigenesis2.04738314
16MP0002723_abnormal_immune_serum2.02019968
17MP0005451_abnormal_body_composition1.99753665
18MP0004742_abnormal_vestibular_system1.97950035
19MP0001800_abnormal_humoral_immune1.96705794
20MP0002452_abnormal_antigen_presenting1.96642899
21MP0002735_abnormal_chemical_nociception1.95304507
22MP0005387_immune_system_phenotype1.93613620
23MP0001790_abnormal_immune_system1.93613620
24MP0002163_abnormal_gland_morphology1.92983677
25MP0010386_abnormal_urinary_bladder1.81188765
26MP0005058_abnormal_lysosome_morphology1.81143442
27MP0008260_abnormal_autophagy1.77828026
28MP0004947_skin_inflammation1.75251331
29MP0003186_abnormal_redox_activity1.70703079
30MP0005310_abnormal_salivary_gland1.69085371
31MP0001819_abnormal_immune_cell1.64040361
32MP0002420_abnormal_adaptive_immunity1.62696273
33MP0005083_abnormal_biliary_tract1.58238585
34MP0009333_abnormal_splenocyte_physiolog1.57785801
35MP0008004_abnormal_stomach_pH1.57314695
36MP0002132_abnormal_respiratory_system1.52362239
37MP0008469_abnormal_protein_level1.49121744
38MP0001845_abnormal_inflammatory_respons1.48464027
39MP0010155_abnormal_intestine_physiology1.48342866
40MP0005166_decreased_susceptibility_to1.42486731
41MP0008877_abnormal_DNA_methylation1.40252847
42MP0000858_altered_metastatic_potential1.38466409
43MP0009697_abnormal_copulation1.36448133
44MP0000015_abnormal_ear_pigmentation1.36410050
45MP0000685_abnormal_immune_system1.30133275
46MP0001853_heart_inflammation1.29504575
47MP0004782_abnormal_surfactant_physiolog1.26559131
48MP0002405_respiratory_system_inflammati1.26184750
49MP0005464_abnormal_platelet_physiology1.24290519
50MP0003763_abnormal_thymus_physiology1.23474833
51MP0003195_calcinosis1.22153851
52MP0001440_abnormal_grooming_behavior1.19525696
53MP0005165_increased_susceptibility_to1.19077077
54MP0002736_abnormal_nociception_after1.19032257
55MP0005379_endocrine/exocrine_gland_phen1.17514578
56MP0003646_muscle_fatigue1.15845581
57MP0004484_altered_response_of1.15130604
58MP0004510_myositis1.14178836
59MP0003191_abnormal_cellular_cholesterol1.14158812
60MP0004147_increased_porphyrin_level1.12988813
61MP0000383_abnormal_hair_follicle1.10919387
62MP0001968_abnormal_touch/_nociception1.08905468
63MP0005535_abnormal_body_temperature1.08494284
64MP0001502_abnormal_circadian_rhythm1.07505130
65MP0001348_abnormal_lacrimal_gland1.05947280
66MP0005647_abnormal_sex_gland1.04587713
67MP0001346_abnormal_lacrimal_gland1.01484296
68MP0003866_abnormal_defecation1.00274687
69MP0005670_abnormal_white_adipose0.99987477
70MP0003448_altered_tumor_morphology0.97144205
71MP0003045_fibrosis0.95336559
72MP0003690_abnormal_glial_cell0.95260431
73MP0003787_abnormal_imprinting0.94992175
74MP0002138_abnormal_hepatobiliary_system0.92380869
75MP0003959_abnormal_lean_body0.92328985
76MP0003252_abnormal_bile_duct0.92224607
77MP0002168_other_aberrant_phenotype0.92190016
78MP0000716_abnormal_immune_system0.92165744
79MP0001727_abnormal_embryo_implantation0.88138122
80MP0009278_abnormal_bone_marrow0.87757621
81MP0000490_abnormal_crypts_of0.87473016
82MP0005646_abnormal_pituitary_gland0.86365022
83MP0002398_abnormal_bone_marrow0.86347045
84MP0003828_pulmonary_edema0.86340270
85MP0002733_abnormal_thermal_nociception0.84128367
86MP0001873_stomach_inflammation0.82618358
87MP0002089_abnormal_postnatal_growth/wei0.79960390
88MP0005645_abnormal_hypothalamus_physiol0.78691452
89MP0001663_abnormal_digestive_system0.78544291
90MP0001533_abnormal_skeleton_physiology0.78335233
91MP0002277_abnormal_respiratory_mucosa0.74398354
92MP0009763_increased_sensitivity_to0.74170601
93MP0009765_abnormal_xenobiotic_induced0.73782609
94MP0006276_abnormal_autonomic_nervous0.73246482
95MP0005360_urolithiasis0.71413175
96MP0003075_altered_response_to0.70699929
97MP0003123_paternal_imprinting0.69956113
98MP0000343_altered_response_to0.67479720
99MP0002429_abnormal_blood_cell0.64685119
100MP0005167_abnormal_blood-brain_barrier0.61438656

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)7.19072352
2Mesomelia (HP:0003027)5.99494875
3Recurrent abscess formation (HP:0002722)5.18042439
4Eczematoid dermatitis (HP:0000976)5.13352021
5Chronic obstructive pulmonary disease (HP:0006510)4.95496904
6Obstructive lung disease (HP:0006536)4.95496904
7Interstitial pulmonary disease (HP:0006530)4.72553675
8Recurrent bacterial skin infections (HP:0005406)4.69605973
9Myositis (HP:0100614)4.45909271
10Azoospermia (HP:0000027)4.24610729
11Stomatitis (HP:0010280)4.02867180
12Systemic lupus erythematosus (HP:0002725)4.02748799
13Abnormal ciliary motility (HP:0012262)3.98581151
14Gingivitis (HP:0000230)3.97527738
15Mediastinal lymphadenopathy (HP:0100721)3.90641023
16Recurrent gram-negative bacterial infections (HP:0005420)3.86121554
17Chromsome breakage (HP:0040012)3.40792248
18Autoimmune thrombocytopenia (HP:0001973)3.39008172
19Vacuolated lymphocytes (HP:0001922)3.36455301
20Neonatal hypoglycemia (HP:0001998)3.35124090
21Chromosomal breakage induced by crosslinking agents (HP:0003221)3.33435511
22Abnormal spermatogenesis (HP:0008669)3.19588910
23Abnormality of T cell number (HP:0011839)3.16781754
24Increased IgM level (HP:0003496)3.14217870
25Recurrent skin infections (HP:0001581)3.01700896
26Pustule (HP:0200039)3.00082532
27Pulmonary infiltrates (HP:0002113)2.98865121
28Gastrointestinal infarctions (HP:0005244)2.95701223
29Vasculitis (HP:0002633)2.89374252
30Combined immunodeficiency (HP:0005387)2.89207732
31Severe combined immunodeficiency (HP:0004430)2.86848140
32Thyroiditis (HP:0100646)2.85166619
33Periodontitis (HP:0000704)2.81815575
34Chronic diarrhea (HP:0002028)2.73440399
35Eosinophilia (HP:0001880)2.72372500
36Abnormal respiratory motile cilium physiology (HP:0012261)2.70409170
37Purpura (HP:0000979)2.69178482
38Abnormality of DNA repair (HP:0003254)2.67424345
39Recurrent fungal infections (HP:0002841)2.60946802
40Abnormality of the prostate (HP:0008775)2.56977370
41Optic neuritis (HP:0100653)2.56598406
42Retrobulbar optic neuritis (HP:0100654)2.56598406
43Autoimmune hemolytic anemia (HP:0001890)2.56417153
44Renal cortical cysts (HP:0000803)2.55189598
45Abnormality of the pleura (HP:0002103)2.53478463
46Prolonged neonatal jaundice (HP:0006579)2.53358563
47T lymphocytopenia (HP:0005403)2.51397109
48Micronodular cirrhosis (HP:0001413)2.47155541
49Leukocytosis (HP:0001974)2.41122872
50Abnormality of eosinophils (HP:0001879)2.37347341
51Petechiae (HP:0000967)2.32636718
52Orchitis (HP:0100796)2.31601805
53Infertility (HP:0000789)2.31309073
54Nephritis (HP:0000123)2.25951059
55Recurrent cutaneous fungal infections (HP:0011370)2.23933642
56Chronic mucocutaneous candidiasis (HP:0002728)2.23933642
57Abnormality of T cells (HP:0002843)2.22183843
58Hemiparesis (HP:0001269)2.20036631
59Nausea (HP:0002018)2.19770699
60Facial cleft (HP:0002006)2.19628266
61Pigmentary retinal degeneration (HP:0001146)2.18287856
62Basal ganglia calcification (HP:0002135)2.17636133
63Median cleft lip (HP:0000161)2.15040756
64Hemorrhage of the eye (HP:0011885)2.14957429
65Abnormal delayed hypersensitivity skin test (HP:0002963)2.14040344
66Hypoproteinemia (HP:0003075)2.11531819
67Abnormality of macrophages (HP:0004311)2.11019998
68Albinism (HP:0001022)2.10060916
69Joint swelling (HP:0001386)2.09828474
70Joint hemorrhage (HP:0005261)2.08496225
71Parakeratosis (HP:0001036)2.07835339
72Poor head control (HP:0002421)2.07766986
73Oligomenorrhea (HP:0000876)2.07738258
74Thrombocytosis (HP:0001894)2.07172017
75Panhypogammaglobulinemia (HP:0003139)2.06350745
76Broad palm (HP:0001169)2.06200248
77Hemoptysis (HP:0002105)2.02911419
78Granulocytopenia (HP:0001913)2.02313061
79Meningitis (HP:0001287)2.00944236
80Septo-optic dysplasia (HP:0100842)1.96657374
81Sensorimotor neuropathy (HP:0007141)1.96451931
82Recurrent sinusitis (HP:0011108)1.96295959
83Corneal erosion (HP:0200020)1.92957346
84Premature loss of primary teeth (HP:0006323)1.92739383
85Prostate neoplasm (HP:0100787)1.91679209
86Hypoplasia of the thymus (HP:0000778)1.90733163
87Postaxial foot polydactyly (HP:0001830)1.87891204
88Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.87783217
89Gingival bleeding (HP:0000225)1.85702288
90Abnormality of the pericardium (HP:0001697)1.84940610
91Amaurosis fugax (HP:0100576)1.82739956
92Gangrene (HP:0100758)1.81617637
93Dynein arm defect of respiratory motile cilia (HP:0012255)1.81484437
94Absent/shortened dynein arms (HP:0200106)1.81484437
95Abnormality of male internal genitalia (HP:0000022)1.80673859
96Onycholysis (HP:0001806)1.80660594
97Anomalous pulmonary venous return (HP:0010772)1.80550355
98Thoracic kyphosis (HP:0002942)1.80044280
99Febrile seizures (HP:0002373)1.79767337
100Arthralgia (HP:0002829)1.79354987

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.59487269
2EIF2AK33.56022211
3MAP2K73.33099409
4TBK13.32313413
5MAP3K123.10049542
6RIPK42.94097541
7PRPF4B2.46069410
8TAOK22.46068583
9EIF2AK22.44066284
10EPHA32.37429993
11FGR2.36979965
12JAK32.27560512
13NTRK32.09793380
14PINK12.05339602
15IRAK32.01995833
16ADRBK21.96210624
17MAP3K141.91922158
18BLK1.88697578
19PRKD31.77923413
20JAK11.73661656
21ACVR1B1.69498813
22MAP2K41.67297757
23PIM21.60966069
24PIK3CG1.60191500
25BCR1.55770454
26MAP3K41.48292642
27DAPK21.47686464
28NUAK11.39269825
29MYLK1.33361183
30DAPK11.32997646
31MAP2K61.32801816
32TNK21.25733684
33CSK1.22554968
34MAP3K131.21718186
35MAP4K11.20994734
36EPHA41.18792840
37BUB11.15735021
38BRD41.14261633
39LYN1.13798106
40IKBKE1.11874144
41KDR1.09959721
42PRKCD1.09337040
43IRAK41.05896206
44TNIK1.04333466
45YES11.03714281
46ZAP701.03037064
47CLK11.00586250
48RAF10.99890309
49DAPK30.99303881
50LCK0.97459768
51BCKDK0.93885396
52IKBKB0.86835470
53SYK0.80057383
54STK30.78776445
55TEC0.76960289
56ATR0.75145885
57MAP3K50.74713557
58MUSK0.72320898
59ITK0.71741824
60BTK0.71033020
61ABL10.69733194
62PRKCQ0.63600718
63TESK10.62832769
64LMTK20.59917785
65MAP3K60.59318892
66FGFR10.58926176
67NEK90.56891567
68ERBB40.54624411
69PDPK10.54473878
70HCK0.54265480
71STK240.54231739
72FRK0.49965282
73MST1R0.48816863
74PDK10.48617652
75MAP3K10.47130575
76ADRBK10.46200846
77JAK20.45083673
78PRKCE0.44903328
79FYN0.43361355
80PRKG20.40422170
81SRC0.37958214
82EGFR0.37189132
83WNK30.37106880
84STK110.36857138
85KSR20.36078664
86WNK10.34475777
87KIT0.33544010
88PIM10.33528784
89OXSR10.32186253
90FGFR40.28802240
91PRKCA0.24767946
92CHUK0.24619812
93TGFBR20.23936261
94CSNK1A10.23637061
95INSR0.23090267
96NLK0.21769356
97PRKCG0.21207100
98ZAK0.20948640
99CAMK2A0.18539723
100GRK70.18057153

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053325.54064331
2Type I diabetes mellitus_Homo sapiens_hsa049403.94210575
3Allograft rejection_Homo sapiens_hsa053303.85617478
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.30526568
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.20754804
6Rheumatoid arthritis_Homo sapiens_hsa053233.09484366
7Leishmaniasis_Homo sapiens_hsa051402.72824560
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.67344641
9Legionellosis_Homo sapiens_hsa051342.46383005
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.42508735
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.26111477
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.23878290
13Malaria_Homo sapiens_hsa051442.11884752
14Pertussis_Homo sapiens_hsa051332.11295721
15Hematopoietic cell lineage_Homo sapiens_hsa046402.08287348
16Autoimmune thyroid disease_Homo sapiens_hsa053202.07682734
17Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.07007059
18Staphylococcus aureus infection_Homo sapiens_hsa051501.94785092
19Salmonella infection_Homo sapiens_hsa051321.94419751
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.91113075
21African trypanosomiasis_Homo sapiens_hsa051431.86155930
22Tuberculosis_Homo sapiens_hsa051521.85431368
23TNF signaling pathway_Homo sapiens_hsa046681.82569622
24Osteoclast differentiation_Homo sapiens_hsa043801.82251080
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.79979172
26Collecting duct acid secretion_Homo sapiens_hsa049661.70192797
27Measles_Homo sapiens_hsa051621.63741869
28Phagosome_Homo sapiens_hsa041451.61399414
29Herpes simplex infection_Homo sapiens_hsa051681.51939735
30Asthma_Homo sapiens_hsa053101.51936433
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39829705
32Amoebiasis_Homo sapiens_hsa051461.35521363
33Primary immunodeficiency_Homo sapiens_hsa053401.34379509
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25738238
35Influenza A_Homo sapiens_hsa051641.25645825
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.23881976
37Antigen processing and presentation_Homo sapiens_hsa046121.16804103
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03212439
39Jak-STAT signaling pathway_Homo sapiens_hsa046300.96704721
40Chemokine signaling pathway_Homo sapiens_hsa040620.93154461
41Ether lipid metabolism_Homo sapiens_hsa005650.87820360
42Prion diseases_Homo sapiens_hsa050200.86886070
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79216636
44Regulation of autophagy_Homo sapiens_hsa041400.77082336
45Hepatitis B_Homo sapiens_hsa051610.73750611
46Complement and coagulation cascades_Homo sapiens_hsa046100.69616368
47Propanoate metabolism_Homo sapiens_hsa006400.69215718
48beta-Alanine metabolism_Homo sapiens_hsa004100.64832872
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.63183270
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61879446
51Non-homologous end-joining_Homo sapiens_hsa034500.59793847
52Toxoplasmosis_Homo sapiens_hsa051450.59648951
53Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59110268
54Hepatitis C_Homo sapiens_hsa051600.57603684
55Apoptosis_Homo sapiens_hsa042100.56513293
56T cell receptor signaling pathway_Homo sapiens_hsa046600.56243149
57One carbon pool by folate_Homo sapiens_hsa006700.50363245
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.47876271
59p53 signaling pathway_Homo sapiens_hsa041150.46609769
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45805340
61Histidine metabolism_Homo sapiens_hsa003400.45168830
62Viral myocarditis_Homo sapiens_hsa054160.44345091
63Vibrio cholerae infection_Homo sapiens_hsa051100.43511256
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42905632
65Mineral absorption_Homo sapiens_hsa049780.39122861
66Other glycan degradation_Homo sapiens_hsa005110.38884274
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38298528
68Synaptic vesicle cycle_Homo sapiens_hsa047210.38241445
69Fatty acid biosynthesis_Homo sapiens_hsa000610.35797486
70Homologous recombination_Homo sapiens_hsa034400.34470035
71Small cell lung cancer_Homo sapiens_hsa052220.32903931
72Lysosome_Homo sapiens_hsa041420.32479213
73Arachidonic acid metabolism_Homo sapiens_hsa005900.32288434
74Proteasome_Homo sapiens_hsa030500.31073401
75Linoleic acid metabolism_Homo sapiens_hsa005910.27689465
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27161249
77Type II diabetes mellitus_Homo sapiens_hsa049300.26706505
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.24867558
79Ovarian steroidogenesis_Homo sapiens_hsa049130.22186338
80Glycerolipid metabolism_Homo sapiens_hsa005610.20628386
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19430538
82HIF-1 signaling pathway_Homo sapiens_hsa040660.18618066
83B cell receptor signaling pathway_Homo sapiens_hsa046620.12361142
84Steroid biosynthesis_Homo sapiens_hsa001000.11514602
85Morphine addiction_Homo sapiens_hsa050320.10840330
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10803772
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.10149317
88Vitamin digestion and absorption_Homo sapiens_hsa049770.09121409
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.08902502
90Retinol metabolism_Homo sapiens_hsa008300.05799162
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.03337037
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.02781694
93Chemical carcinogenesis_Homo sapiens_hsa052040.02458410
94ECM-receptor interaction_Homo sapiens_hsa045120.02182050
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.01245875
96Epstein-Barr virus infection_Homo sapiens_hsa051690.00275064
97Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0159058
98Fanconi anemia pathway_Homo sapiens_hsa03460-0.0144560
99ABC transporters_Homo sapiens_hsa02010-0.0087907
100Arginine and proline metabolism_Homo sapiens_hsa00330-0.0057969

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