MAGEB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.37942330
2synaptonemal complex organization (GO:0070193)9.29162605
3gonadal mesoderm development (GO:0007506)8.26242048
4DNA methylation involved in gamete generation (GO:0043046)7.28580703
5purine nucleobase biosynthetic process (GO:0009113)6.59906344
6chromosome organization involved in meiosis (GO:0070192)6.40401811
7meiotic chromosome segregation (GO:0045132)6.12607945
8nuclear pore complex assembly (GO:0051292)6.05048896
9male meiosis I (GO:0007141)5.95798860
10meiotic nuclear division (GO:0007126)5.88268183
11male meiosis (GO:0007140)5.88121506
12meiosis I (GO:0007127)5.45804126
13nucleobase biosynthetic process (GO:0046112)5.45082649
14resolution of meiotic recombination intermediates (GO:0000712)5.44367331
15synapsis (GO:0007129)5.37307437
16regulation of meiosis I (GO:0060631)5.29764922
17nuclear pore organization (GO:0006999)5.29536195
18proteasome assembly (GO:0043248)5.14399419
19reciprocal meiotic recombination (GO:0007131)5.11541942
20reciprocal DNA recombination (GO:0035825)5.11541942
21mitotic chromosome condensation (GO:0007076)4.99970624
22DNA replication checkpoint (GO:0000076)4.84316232
23meiotic cell cycle process (GO:1903046)4.82784002
24ribosome assembly (GO:0042255)4.80641800
25formation of translation preinitiation complex (GO:0001731)4.57999564
26mitotic metaphase plate congression (GO:0007080)4.50903079
27pore complex assembly (GO:0046931)4.46670694
28DNA synthesis involved in DNA repair (GO:0000731)4.32728989
29DNA unwinding involved in DNA replication (GO:0006268)4.31759009
30kinetochore assembly (GO:0051382)4.27544531
31proline biosynthetic process (GO:0006561)4.22329946
32attachment of spindle microtubules to kinetochore (GO:0008608)4.17467894
33kinetochore organization (GO:0051383)4.15693563
34mitotic sister chromatid cohesion (GO:0007064)4.08111273
35chromatin remodeling at centromere (GO:0031055)4.07092089
36folic acid metabolic process (GO:0046655)4.06562138
37mitotic nuclear envelope disassembly (GO:0007077)4.04553063
38histone exchange (GO:0043486)3.98305163
39regulation of translational fidelity (GO:0006450)3.97219808
40mitotic sister chromatid segregation (GO:0000070)3.87811160
41ribosome biogenesis (GO:0042254)3.84679078
42blastocyst development (GO:0001824)3.83040777
43membrane disassembly (GO:0030397)3.80247174
44nuclear envelope disassembly (GO:0051081)3.80247174
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.79430531
46folic acid transport (GO:0015884)3.77281136
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.76143507
48metaphase plate congression (GO:0051310)3.75638055
49DNA strand elongation (GO:0022616)3.74926694
50mitotic spindle checkpoint (GO:0071174)3.72433902
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.71526935
52regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.70742585
53establishment of integrated proviral latency (GO:0075713)3.70298961
54mitotic spindle assembly checkpoint (GO:0007094)3.69114897
55CENP-A containing nucleosome assembly (GO:0034080)3.68353451
56telomere maintenance via semi-conservative replication (GO:0032201)3.65800285
57spindle checkpoint (GO:0031577)3.65322756
58ribosomal large subunit biogenesis (GO:0042273)3.62811820
59positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.61527536
60DNA replication-independent nucleosome organization (GO:0034724)3.60089972
61DNA replication-independent nucleosome assembly (GO:0006336)3.60089972
62regulation of double-strand break repair via homologous recombination (GO:0010569)3.59139381
63spindle assembly checkpoint (GO:0071173)3.58422536
64sister chromatid segregation (GO:0000819)3.56208043
65negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.56047198
66negative regulation of sister chromatid segregation (GO:0033046)3.56047198
67negative regulation of mitotic sister chromatid separation (GO:2000816)3.56047198
68negative regulation of mitotic sister chromatid segregation (GO:0033048)3.56047198
69negative regulation of chromosome segregation (GO:0051985)3.55359308
70negative regulation of meiosis (GO:0045835)3.53831341
71gene silencing by RNA (GO:0031047)3.53682383
72ribonucleoprotein complex biogenesis (GO:0022613)3.52849832
737-methylguanosine mRNA capping (GO:0006370)3.51797831
74DNA methylation (GO:0006306)3.50710064
75DNA alkylation (GO:0006305)3.50710064
76termination of RNA polymerase III transcription (GO:0006386)3.49421589
77transcription elongation from RNA polymerase III promoter (GO:0006385)3.49421589
78negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.44029093
79oocyte maturation (GO:0001556)3.43737877
80regulation of chromosome segregation (GO:0051983)3.43080185
81RNA capping (GO:0036260)3.39849736
827-methylguanosine RNA capping (GO:0009452)3.39849736
83vitamin transmembrane transport (GO:0035461)3.39016323
84positive regulation of ligase activity (GO:0051351)3.37875953
85DNA replication-dependent nucleosome organization (GO:0034723)3.37776719
86DNA replication-dependent nucleosome assembly (GO:0006335)3.37776719
87maturation of SSU-rRNA (GO:0030490)3.36881550
88maturation of 5.8S rRNA (GO:0000460)3.36695882
89protein K6-linked ubiquitination (GO:0085020)3.32202685
90negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.31857234
91negative regulation of ligase activity (GO:0051352)3.31857234
92sister chromatid cohesion (GO:0007062)3.30197760
93protoporphyrinogen IX biosynthetic process (GO:0006782)3.29602949
94regulation of spindle organization (GO:0090224)3.29576253
95regulation of mitotic metaphase/anaphase transition (GO:0030071)3.28589684
96DNA deamination (GO:0045006)3.27779396
97regulation of cellular amino acid metabolic process (GO:0006521)3.27538259
98regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.26875363
99protoporphyrinogen IX metabolic process (GO:0046501)3.25685916
100DNA replication initiation (GO:0006270)3.23722778
101signal transduction involved in DNA integrity checkpoint (GO:0072401)3.22927455
102signal transduction involved in DNA damage checkpoint (GO:0072422)3.22927455
103protein localization to chromosome, centromeric region (GO:0071459)3.22457846
104rRNA modification (GO:0000154)3.21796353
105IMP biosynthetic process (GO:0006188)3.21748406
106regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.19927000
107oogenesis (GO:0048477)3.19185465
108signal transduction involved in cell cycle checkpoint (GO:0072395)3.17374629
109signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.17169036
110signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.17169036
111signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.17169036
112telomere maintenance via recombination (GO:0000722)3.16563282
113termination of RNA polymerase I transcription (GO:0006363)3.16387910
114transcription elongation from RNA polymerase I promoter (GO:0006362)3.15555214
115DNA strand elongation involved in DNA replication (GO:0006271)3.15153210
116nucleobase-containing small molecule interconversion (GO:0015949)3.15077512
117protein localization to chromosome (GO:0034502)3.14632132
118regulation of mitotic sister chromatid separation (GO:0010965)3.14425056
119regulation of mitotic sister chromatid segregation (GO:0033047)3.14425056
120regulation of sister chromatid segregation (GO:0033045)3.14425056
121CDP-diacylglycerol metabolic process (GO:0046341)3.13910547
122regulation of ubiquitin-protein transferase activity (GO:0051438)3.13678931
123centriole assembly (GO:0098534)3.13236088
124DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.12982221
125chromosome segregation (GO:0007059)3.11499523
126chaperone-mediated protein complex assembly (GO:0051131)3.11424768
127signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.11308311
128intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.11308311
129lung-associated mesenchyme development (GO:0060484)3.11157198
130folic acid-containing compound biosynthetic process (GO:0009396)3.11128973
131regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.09047667
132chromosome condensation (GO:0030261)3.07963240
133transcription from mitochondrial promoter (GO:0006390)3.07653973
134regulation of mitochondrial translation (GO:0070129)3.07581668
135peptidyl-threonine dephosphorylation (GO:0035970)3.07475659
136transcription from RNA polymerase I promoter (GO:0006360)3.06234386
137ribosomal small subunit biogenesis (GO:0042274)3.04606471
138regulation of RNA export from nucleus (GO:0046831)3.02962951
139mitotic recombination (GO:0006312)3.02770879
140protein localization to kinetochore (GO:0034501)3.01094158
141DNA packaging (GO:0006323)2.93172325
142DNA topological change (GO:0006265)2.93053178
143tRNA aminoacylation for protein translation (GO:0006418)2.90586872
144rRNA processing (GO:0006364)2.90415820
145nuclear envelope organization (GO:0006998)2.87833429
146COPI coating of Golgi vesicle (GO:0048205)2.86010003
147Golgi transport vesicle coating (GO:0048200)2.86010003
148non-recombinational repair (GO:0000726)2.85925893
149double-strand break repair via nonhomologous end joining (GO:0006303)2.85925893
150binding of sperm to zona pellucida (GO:0007339)2.85229753
151diterpenoid biosynthetic process (GO:0016102)2.83427639
152regulation of mitotic spindle organization (GO:0060236)2.83075532
153tRNA aminoacylation (GO:0043039)2.80448820
154amino acid activation (GO:0043038)2.80448820
155mitochondrial DNA metabolic process (GO:0032042)2.79551775
156pteridine-containing compound biosynthetic process (GO:0042559)2.78927394
157regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.78609174
158proline metabolic process (GO:0006560)2.77304446
159rRNA metabolic process (GO:0016072)2.75550371
160establishment of viral latency (GO:0019043)2.75275778
161IMP metabolic process (GO:0046040)2.73560656
162synaptonemal complex assembly (GO:0007130)10.2698029

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.20365883
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.72780514
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.45388469
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.02077762
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.95008650
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.79912789
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.67674568
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.67328351
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.53642353
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.45611210
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.31350489
12E2F4_17652178_ChIP-ChIP_JURKAT_Human3.30853009
13EST1_17652178_ChIP-ChIP_JURKAT_Human3.21066827
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93673764
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.87864174
16AR_21909140_ChIP-Seq_LNCAP_Human2.87000925
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.84365011
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.81159585
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.77791309
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.76160364
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.69570983
22VDR_23849224_ChIP-Seq_CD4+_Human2.48673037
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.40016774
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14162610
25MYCN_18555785_ChIP-Seq_MESCs_Mouse2.13800686
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.11845966
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.06229871
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02350223
29XRN2_22483619_ChIP-Seq_HELA_Human1.98663744
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96354877
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93722555
32GABP_19822575_ChIP-Seq_HepG2_Human1.92058276
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88840114
34PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.86244206
35DCP1A_22483619_ChIP-Seq_HELA_Human1.85201124
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.82827483
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78195210
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74871364
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.73694969
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71866299
41ZNF263_19887448_ChIP-Seq_K562_Human1.70228500
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.69413962
43FOXP3_21729870_ChIP-Seq_TREG_Human1.68964352
44TTF2_22483619_ChIP-Seq_HELA_Human1.58485785
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58237683
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54686917
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43657985
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.43047472
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.43047472
50KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.43047472
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42527812
52ELK1_19687146_ChIP-ChIP_HELA_Human1.42088339
53CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.37676171
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35943364
55HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34478653
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30855228
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30328509
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28093114
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25494887
60KDM5A_27292631_Chip-Seq_BREAST_Human1.24814549
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24523200
62SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.22832875
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22645113
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20091777
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19383234
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.18873633
67ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10905616
68NCOR1_26117541_ChIP-Seq_K562_Human1.10436625
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09329268
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09233694
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.04584134
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03939500
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.03353332
74TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02790345
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.99248046
76GATA1_26923725_Chip-Seq_HPCs_Mouse0.97573981
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97242514
78MYC_22102868_ChIP-Seq_BL_Human0.95894864
79BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95674435
80CIITA_25753668_ChIP-Seq_RAJI_Human0.95592114
81TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95561226
82ATF3_27146783_Chip-Seq_COLON_Human0.94963909
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94701669
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94178246
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93035675
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92909895
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92733847
88SALL1_21062744_ChIP-ChIP_HESCs_Human0.91963067
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91951011
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91770273
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91410889
92EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91137156
93HTT_18923047_ChIP-ChIP_STHdh_Human0.91106382
94TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.91075684
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87615799
96HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86993548
97* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86834738
98HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86780018
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86294840
100CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86093142
101NANOG_21062744_ChIP-ChIP_HESCs_Human0.86077620
102SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85532237
103SOX17_20123909_ChIP-Seq_XEN_Mouse0.83581876
104CHD1_26751641_Chip-Seq_LNCaP_Human0.81438527
105TFEB_21752829_ChIP-Seq_HELA_Human0.80715224
106TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80498719
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79667087
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79018569
109NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78308255
110NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.77798563
111SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.76549825
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.76389483
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76060200
114GATA4_21415370_ChIP-Seq_HL-1_Mouse0.75865463
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.75203667
116RBPJ_22232070_ChIP-Seq_NCS_Mouse0.74408078
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73971273
118SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.73869032
119SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.73845815
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.73480616
121MYC_18940864_ChIP-ChIP_HL60_Human0.72880149
122TP63_19390658_ChIP-ChIP_HaCaT_Human0.71974181
123GATA3_21867929_ChIP-Seq_TH1_Mouse0.69986133
124OCT4_18692474_ChIP-Seq_MEFs_Mouse0.69458264
125NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.68146574

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation7.42378730
2MP0008995_early_reproductive_senescence5.34081487
3MP0003693_abnormal_embryo_hatching5.18927872
4MP0003786_premature_aging4.85605618
5MP0003111_abnormal_nucleus_morphology4.49977407
6MP0008058_abnormal_DNA_repair3.94069019
7MP0010094_abnormal_chromosome_stability3.72584968
8MP0003123_paternal_imprinting3.51459256
9MP0004957_abnormal_blastocyst_morpholog3.47910342
10MP0002210_abnormal_sex_determination3.32039140
11MP0009697_abnormal_copulation3.29084540
12MP0003718_maternal_effect3.26963086
13MP0003077_abnormal_cell_cycle2.95617765
14MP0005451_abnormal_body_composition2.82772645
15MP0001145_abnormal_male_reproductive2.75362982
16MP0001929_abnormal_gametogenesis2.75099608
17MP0010234_abnormal_vibrissa_follicle2.59656481
18MP0008260_abnormal_autophagy2.49403269
19MP0000653_abnormal_sex_gland2.44656395
20MP0008932_abnormal_embryonic_tissue2.23804348
21MP0003698_abnormal_male_reproductive2.16395414
22MP0008057_abnormal_DNA_replication1.99484796
23MP0009840_abnormal_foam_cell1.92102818
24MP0004233_abnormal_muscle_weight1.91026086
25MP0002877_abnormal_melanocyte_morpholog1.89273230
26MP0001730_embryonic_growth_arrest1.88315787
27MP0005377_hearing/vestibular/ear_phenot1.84592359
28MP0003878_abnormal_ear_physiology1.84592359
29MP0004185_abnormal_adipocyte_glucose1.78410530
30MP0000678_abnormal_parathyroid_gland1.71335393
31MP0001661_extended_life_span1.70915576
32MP0000350_abnormal_cell_proliferation1.53273058
33MP0004084_abnormal_cardiac_muscle1.40475220
34MP0002161_abnormal_fertility/fecundity1.40258361
35MP0008007_abnormal_cellular_replicative1.39444431
36MP0003315_abnormal_perineum_morphology1.39300010
37MP0005670_abnormal_white_adipose1.35370424
38MP0001542_abnormal_bone_strength1.35264504
39MP0009379_abnormal_foot_pigmentation1.33003539
40MP0002396_abnormal_hematopoietic_system1.29783478
41MP0001672_abnormal_embryogenesis/_devel1.29473683
42MP0005380_embryogenesis_phenotype1.29473683
43MP0000015_abnormal_ear_pigmentation1.28690627
44MP0005395_other_phenotype1.25991993
45MP0004808_abnormal_hematopoietic_stem1.20329612
46MP0004019_abnormal_vitamin_homeostasis1.20262176
47MP0005076_abnormal_cell_differentiation1.19030915
48MP0001697_abnormal_embryo_size1.12914244
49MP0009333_abnormal_splenocyte_physiolog1.12550041
50MP0010352_gastrointestinal_tract_polyps1.11746728
51MP0005501_abnormal_skin_physiology1.11213427
52MP0003984_embryonic_growth_retardation1.10045759
53MP0008961_abnormal_basal_metabolism1.09258718
54MP0003656_abnormal_erythrocyte_physiolo1.07707474
55MP0003221_abnormal_cardiomyocyte_apopto1.05983026
56MP0001119_abnormal_female_reproductive1.05812747
57MP0002088_abnormal_embryonic_growth/wei1.05348582
58MP0003941_abnormal_skin_development1.05322194
59MP0002080_prenatal_lethality1.04923379
60MP0000313_abnormal_cell_death1.04087141
61MP0009672_abnormal_birth_weight1.02323485
62MP0010307_abnormal_tumor_latency1.00931305
63MP0001756_abnormal_urination1.00377626
64MP0002970_abnormal_white_adipose0.97757475
65MP0003385_abnormal_body_wall0.96889970
66MP0003938_abnormal_ear_development0.95018836
67MP0005397_hematopoietic_system_phenotyp0.94774822
68MP0001545_abnormal_hematopoietic_system0.94774822
69MP0002102_abnormal_ear_morphology0.94619317
70MP0003806_abnormal_nucleotide_metabolis0.93788321
71MP0003699_abnormal_female_reproductive0.93372824
72MP0002085_abnormal_embryonic_tissue0.93312817
73MP0010678_abnormal_skin_adnexa0.91277657
74MP0001348_abnormal_lacrimal_gland0.89290398
75MP0000490_abnormal_crypts_of0.88735716
76MP0003121_genomic_imprinting0.88339821
77MP0002095_abnormal_skin_pigmentation0.86523052
78MP0003890_abnormal_embryonic-extraembry0.84347305
79MP0009703_decreased_birth_body0.83008928
80MP0003943_abnormal_hepatobiliary_system0.82315877
81MP0001764_abnormal_homeostasis0.82116975
82MP0003567_abnormal_fetal_cardiomyocyte0.81458811
83MP0005410_abnormal_fertilization0.80880029
84MP0001727_abnormal_embryo_implantation0.80322118
85MP0005083_abnormal_biliary_tract0.79201511
86MP0003453_abnormal_keratinocyte_physiol0.78654741
87MP0002019_abnormal_tumor_incidence0.77844506
88MP0006036_abnormal_mitochondrial_physio0.77080389
89MP0005666_abnormal_adipose_tissue0.76961148
90MP0001915_intracranial_hemorrhage0.73868791
91MP0003959_abnormal_lean_body0.72361271
92MP0004147_increased_porphyrin_level0.71474214
93MP0002084_abnormal_developmental_patter0.71424145
94MP0009115_abnormal_fat_cell0.71120852
95MP0005409_darkened_coat_color0.70774269
96MP0003950_abnormal_plasma_membrane0.70548324
97MP0002160_abnormal_reproductive_system0.69298782
98MP0003936_abnormal_reproductive_system0.69010055
99MP0000647_abnormal_sebaceous_gland0.66596079
100MP0005384_cellular_phenotype0.66056601
101MP0005621_abnormal_cell_physiology0.66051645
102MP0001881_abnormal_mammary_gland0.65311548
103MP0005408_hypopigmentation0.64999360
104MP0005174_abnormal_tail_pigmentation0.64929971
105MP0000358_abnormal_cell_content/0.64489165
106MP0002086_abnormal_extraembryonic_tissu0.64430092
107MP0004197_abnormal_fetal_growth/weight/0.64379455
108MP0005332_abnormal_amino_acid0.63308089
109MP0002269_muscular_atrophy0.63215721
110MP0005330_cardiomyopathy0.62659468
111MP0004145_abnormal_muscle_electrophysio0.61853484
112MP0000750_abnormal_muscle_regeneration0.61799357
113MP0004742_abnormal_vestibular_system0.61382988
114MP0005389_reproductive_system_phenotype0.60413546
115MP0000747_muscle_weakness0.58408211
116MP0003937_abnormal_limbs/digits/tail_de0.57877467
117MP0006035_abnormal_mitochondrial_morpho0.57695599
118MP0000428_abnormal_craniofacial_morphol0.56509508
119MP0003119_abnormal_digestive_system0.56154043
120MP0006138_congestive_heart_failure0.54062790
121MP0003186_abnormal_redox_activity0.53295735
122MP0006292_abnormal_olfactory_placode0.50482895
123MP0000534_abnormal_ureter_morphology0.50244525
124MP0004215_abnormal_myocardial_fiber0.49396477
125MP0003646_muscle_fatigue0.49258882
126MP0002111_abnormal_tail_morphology0.46676297
127MP0002092_abnormal_eye_morphology0.46271219
128MP0001293_anophthalmia0.46243217
129MP0000383_abnormal_hair_follicle0.42236432
130MP0004036_abnormal_muscle_relaxation0.41526303
131MP0001485_abnormal_pinna_reflex0.39186725
132MP0000537_abnormal_urethra_morphology0.39130994
133MP0000627_abnormal_mammary_gland0.38708031
134MP0005623_abnormal_meninges_morphology0.37033219
135MP0002796_impaired_skin_barrier0.35578029
136MP0003879_abnormal_hair_cell0.35282467

Predicted human phenotypes

RankGene SetZ-score
1Azoospermia (HP:0000027)8.43698338
2Abnormal spermatogenesis (HP:0008669)7.75757682
3Carpal bone hypoplasia (HP:0001498)5.44067547
4Breast hypoplasia (HP:0003187)5.29447265
5Birth length less than 3rd percentile (HP:0003561)4.46017083
6Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.97579373
7Ureteral duplication (HP:0000073)3.89840857
8Cerebral hypomyelination (HP:0006808)3.85726363
9Abnormality of the labia minora (HP:0012880)3.75618787
10Rough bone trabeculation (HP:0100670)3.70560370
11Absent radius (HP:0003974)3.64841568
12Impulsivity (HP:0100710)3.59871598
13Shoulder girdle muscle weakness (HP:0003547)3.57420042
14Tetraplegia (HP:0002445)3.51519053
15Aplasia involving forearm bones (HP:0009822)3.50700983
16Absent forearm bone (HP:0003953)3.50700983
17Aplasia/Hypoplasia involving the musculature (HP:0001460)3.45908667
18Oligodactyly (hands) (HP:0001180)3.26107690
19Microvesicular hepatic steatosis (HP:0001414)3.24327288
20Gout (HP:0001997)3.19247831
21Spontaneous abortion (HP:0005268)3.18298954
22Patellar aplasia (HP:0006443)3.18261336
23Aplasia/Hypoplasia of the patella (HP:0006498)3.16598403
24Horseshoe kidney (HP:0000085)3.13202115
25Increased nuchal translucency (HP:0010880)3.12645543
26Reticulocytopenia (HP:0001896)3.11332411
27Diaphragmatic weakness (HP:0009113)3.05299372
28Chromsome breakage (HP:0040012)3.02779205
29Abnormality of reticulocytes (HP:0004312)3.01691058
30Truncus arteriosus (HP:0001660)2.97438845
31Reticulocytosis (HP:0001923)2.97124101
32Cholecystitis (HP:0001082)2.96176558
33Abnormal gallbladder physiology (HP:0012438)2.96176558
34Muscle fiber splitting (HP:0003555)2.90498881
35Abnormality of the lower motor neuron (HP:0002366)2.90043579
36Facial hemangioma (HP:0000329)2.88967855
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.88812787
38Ankyloglossia (HP:0010296)2.84328937
39Pelvic girdle muscle weakness (HP:0003749)2.83857764
40Oligodactyly (HP:0012165)2.80959492
41Hyperglycinemia (HP:0002154)2.77408822
42Abnormality of the anterior horn cell (HP:0006802)2.76433901
43Degeneration of anterior horn cells (HP:0002398)2.76433901
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.74897579
45Capillary hemangiomas (HP:0005306)2.74454674
46Abnormality of the umbilical cord (HP:0010881)2.73647035
47Abnormal trabecular bone morphology (HP:0100671)2.73491744
48Ankle contracture (HP:0006466)2.72543698
49Insomnia (HP:0100785)2.70057627
50Entropion (HP:0000621)2.69792025
51Volvulus (HP:0002580)2.69567666
52Duodenal stenosis (HP:0100867)2.68862258
53Small intestinal stenosis (HP:0012848)2.68862258
54Spinal muscular atrophy (HP:0007269)2.66229092
55Abnormality of glycolysis (HP:0004366)2.65907871
56Proximal placement of thumb (HP:0009623)2.58475134
57Pallor (HP:0000980)2.58323305
58Myelodysplasia (HP:0002863)2.58089333
59Premature ovarian failure (HP:0008209)2.54056313
60Prolonged neonatal jaundice (HP:0006579)2.53050215
61Abnormality of DNA repair (HP:0003254)2.53027459
62Progressive muscle weakness (HP:0003323)2.51989163
63Atrophy/Degeneration involving motor neurons (HP:0007373)2.51311668
64Poikiloderma (HP:0001029)2.50043660
65Increased serum pyruvate (HP:0003542)2.45743753
66Short nail (HP:0001799)2.43608763
67Secondary amenorrhea (HP:0000869)2.42045882
68Abnormality of the distal phalanges of the toes (HP:0010182)2.38478837
69Hyperthyroidism (HP:0000836)2.38325221
70Abnormality of the musculature of the pelvis (HP:0001469)2.37101505
71Abnormality of the hip-girdle musculature (HP:0001445)2.37101505
72Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.36862960
73Abnormality of alanine metabolism (HP:0010916)2.33167574
74Hyperalaninemia (HP:0003348)2.33167574
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33167574
76Deviation of the thumb (HP:0009603)2.33132164
77Bowel incontinence (HP:0002607)2.33012699
78Absent thumb (HP:0009777)2.32335447
79Shawl scrotum (HP:0000049)2.30503610
80Hyperglycinuria (HP:0003108)2.30490346
81Premature rupture of membranes (HP:0001788)2.30105209
82Meckel diverticulum (HP:0002245)2.28864195
83Abnormality of the tricuspid valve (HP:0001702)2.28553301
84Upper limb muscle weakness (HP:0003484)2.28488503
85Male infertility (HP:0003251)2.24903676
86Abnormal large intestine physiology (HP:0012700)2.24690469
87CNS hypomyelination (HP:0003429)2.23388907
88Aplasia/Hypoplasia of the earlobes (HP:0009906)2.23338739
89Abnormality of the renal collecting system (HP:0004742)2.21718388
90Abnormal delivery (HP:0001787)2.19480273
91Microglossia (HP:0000171)2.15495792
92Abnormality of oral frenula (HP:0000190)2.15431434
93Megaloblastic anemia (HP:0001889)2.15194139
94Cafe-au-lait spot (HP:0000957)2.14871959
95Amyotrophic lateral sclerosis (HP:0007354)2.13385373
96Gonadotropin excess (HP:0000837)2.13092512
97Fused cervical vertebrae (HP:0002949)2.11341677
98Stillbirth (HP:0003826)2.10102714
99Abnormality of serine family amino acid metabolism (HP:0010894)2.09948402
100Abnormality of glycine metabolism (HP:0010895)2.09948402
101Degeneration of the lateral corticospinal tracts (HP:0002314)2.09928753
102Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.09928753
103Supernumerary spleens (HP:0009799)2.09786631
104Cortical dysplasia (HP:0002539)2.09607417
105Duplicated collecting system (HP:0000081)2.09421549
106Ragged-red muscle fibers (HP:0003200)2.08098035
107Abnormality of chromosome stability (HP:0003220)2.07369035
108Death in infancy (HP:0001522)2.06476790
109Personality changes (HP:0000751)2.06019119
110Cleft eyelid (HP:0000625)2.05613948
111Short middle phalanx of the 5th finger (HP:0004220)2.05506761
112Areflexia of lower limbs (HP:0002522)2.05457553
113External ophthalmoplegia (HP:0000544)2.04000341
114Abnormality of the ileum (HP:0001549)2.03677999
115Aplasia/hypoplasia of the uterus (HP:0008684)2.03402146
116Congenital, generalized hypertrichosis (HP:0004540)2.02492826
117Difficulty climbing stairs (HP:0003551)2.02138227
118Aplasia/Hypoplasia of the ulna (HP:0006495)2.01707577
119Upper motor neuron abnormality (HP:0002127)2.01678793
120Increased serum lactate (HP:0002151)2.01370273
121Rimmed vacuoles (HP:0003805)2.00880763
122Delusions (HP:0000746)2.00317460
123Colon cancer (HP:0003003)2.00048823
124Wrist flexion contracture (HP:0001239)1.99476278
125Proximal tubulopathy (HP:0000114)1.99232052
126Squamous cell carcinoma (HP:0002860)1.98680618
127Autoamputation (HP:0001218)1.98625002
128Progressive external ophthalmoplegia (HP:0000590)1.98131371
129Abnormality of serum amino acid levels (HP:0003112)1.97871476
130Abnormal lung lobation (HP:0002101)1.97654801
131Atrioventricular block (HP:0001678)1.97334104
132Aplasia/hypoplasia of the humerus (HP:0006507)1.96673007
133Abnormality of cells of the erythroid lineage (HP:0012130)1.96209466
134Pili torti (HP:0003777)1.96174694
135Abnormality of the preputium (HP:0100587)1.95355040
136Osteolytic defects of the hand bones (HP:0009699)1.94472316
137Osteolytic defects of the phalanges of the hand (HP:0009771)1.94472316
138Abnormality of aromatic amino acid family metabolism (HP:0004338)1.93520094
139Hypergonadotropic hypogonadism (HP:0000815)1.93487858
140Segmental peripheral demyelination/remyelination (HP:0003481)1.92880601
141Horizontal nystagmus (HP:0000666)1.92864341
142Ileus (HP:0002595)1.92659859
143Abnormalities of placenta or umbilical cord (HP:0001194)1.92270477
144Conjunctival telangiectasia (HP:0000524)1.92062002
145Choanal atresia (HP:0000453)1.91970740
146Abnormality of the duodenum (HP:0002246)1.90205514
147Sparse eyelashes (HP:0000653)1.86876666
148Hypoparathyroidism (HP:0000829)1.86417842
149Orthostatic hypotension (HP:0001278)1.85841586
150Microretrognathia (HP:0000308)1.85077602
151Anal stenosis (HP:0002025)1.84852282
152Unsteady gait (HP:0002317)1.84814034
153Abnormality of the carotid arteries (HP:0005344)1.84584457
154Aplasia of the musculature (HP:0100854)1.83988374
155Abnormal hemoglobin (HP:0011902)1.82476749
156Delayed myelination (HP:0012448)1.81992497
157Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81744356
158Short thumb (HP:0009778)1.81544478
159Nephroblastoma (Wilms tumor) (HP:0002667)1.80474859
160Papillary thyroid carcinoma (HP:0002895)1.79986854
161Hypertensive crisis (HP:0100735)1.78309266
162Macrocytic anemia (HP:0001972)1.77957010
163Unilateral renal agenesis (HP:0000122)1.76406803
164Decreased subcutaneous fat (HP:0001002)1.74840568
165Cutaneous melanoma (HP:0012056)1.72946385
166Scotoma (HP:0000575)1.72683503
167Impaired proprioception (HP:0010831)1.72185655
168Hypoplasia of the pons (HP:0012110)1.70193689
169Overlapping toe (HP:0001845)1.69030578
170Lactic acidosis (HP:0003128)1.68540183
171Multiple enchondromatosis (HP:0005701)1.68374039

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.74154743
2WEE14.49316514
3ACVR1B3.93597094
4MST1R3.85255164
5CDC73.39280167
6EPHA23.30771048
7AKT33.05978258
8STK162.96634742
9NEK22.83053152
10PLK42.79872358
11NEK12.62240393
12EIF2AK12.51614169
13BRSK22.48892994
14TTK2.34891878
15PLK12.23104045
16SRPK12.09335158
17PINK12.06627067
18PDK32.00337262
19PDK42.00337262
20MET1.98445247
21EIF2AK31.86830220
22BRSK11.77898093
23KSR21.76779047
24PLK31.56820097
25IRAK31.55702199
26NME11.54455911
27TSSK61.53164330
28WNK41.47259550
29EEF2K1.46905228
30STK101.46310951
31MUSK1.45120014
32PNCK1.42415387
33MKNK21.40283162
34ZAK1.39247168
35DYRK31.36817115
36STK391.33204594
37CCNB11.31849818
38PDK21.24878948
39RAF11.23910793
40PRPF4B1.23011167
41TAOK21.18120448
42AURKB1.17579110
43CHEK11.17354591
44CHEK21.17354174
45BMPR21.14257819
46AURKA1.14252403
47BRD41.10266331
48ICK1.07934588
49MKNK11.07467248
50BMX1.05234380
51CLK11.00424293
52PRKCI0.98433529
53ALK0.98261742
54MAP3K80.97130694
55ATR0.92046292
56STK30.88748016
57CDK70.88674864
58PBK0.85364183
59EIF2AK20.82745119
60STK38L0.82734099
61MAP3K30.79820793
62MAP3K90.79121320
63BRAF0.79028931
64TNIK0.78821636
65TAF10.78312778
66ERBB40.78205376
67YES10.77396612
68ATM0.75641777
69AKT20.73964491
70CSNK1G30.72171505
71CDK40.71862754
72STK40.71104491
73CDK20.69111862
74LRRK20.68873089
75BCKDK0.66031151
76TESK20.65107786
77LATS20.65047344
78MARK10.64435548
79WNK30.62858181
80DYRK20.62718826
81MELK0.61571573
82STK240.61160506
83NTRK30.60754973
84FGFR10.60612531
85CDK10.60499723
86CSNK2A20.60071398
87ARAF0.58779685
88MAP3K120.57824130
89CDK120.56857377
90BCR0.55992119
91CSNK1G10.55540983
92MAP2K20.54429461
93CSNK2A10.54422603
94NME20.54411976
95CSNK1A1L0.54191838
96CSNK1E0.54171814
97NEK60.53864454
98CSNK1G20.52681749
99PAK10.52513782
100VRK10.50748032
101RPS6KA40.49142399
102ABL20.46809058
103PIM10.46464831
104PAK40.45582030
105RPS6KB20.45227609
106NUAK10.44074858
107PASK0.42027152
108CDK80.41548054
109MARK30.39630490
110LATS10.39371367
111SCYL20.34136398
112KSR10.31580152
113PIM20.31255828
114ERBB30.30765003
115PRKDC0.29847976
116PRKCG0.29239236
117MAP3K140.28870087
118WNK10.28282063
119RPS6KB10.28069132
120TESK10.27279199
121MAP3K100.26147196
122IRAK20.23566029
123MAPK140.22741445
124LIMK10.22685477
125MST40.21261573
126CDK11A0.21098666
127GRK10.20189096
128CDC42BPA0.20152408
129CSNK1A10.18819378
130GSK3B0.18400809
131RPS6KA50.17917171
132MAP2K10.17802997
133PRKG20.17435229
134MAP3K10.17026906
135PTK20.16725310
136MAP3K20.16491212
137MAPK80.16389974
138MTOR0.14365827
139CAMK2B0.12978175

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030085.29837950
2Proteasome_Homo sapiens_hsa030505.03917865
3RNA polymerase_Homo sapiens_hsa030204.08953000
4Vitamin B6 metabolism_Homo sapiens_hsa007504.02518742
5RNA transport_Homo sapiens_hsa030133.48017274
6Homologous recombination_Homo sapiens_hsa034403.34635180
7DNA replication_Homo sapiens_hsa030303.28728039
8Basal transcription factors_Homo sapiens_hsa030222.89941255
9Mismatch repair_Homo sapiens_hsa034302.79016553
10Cell cycle_Homo sapiens_hsa041102.67257912
11Spliceosome_Homo sapiens_hsa030402.61024980
12Pyrimidine metabolism_Homo sapiens_hsa002402.53638567
13Base excision repair_Homo sapiens_hsa034102.36988688
14Nucleotide excision repair_Homo sapiens_hsa034202.16927589
15Regulation of autophagy_Homo sapiens_hsa041402.01519790
16Folate biosynthesis_Homo sapiens_hsa007901.97253850
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.86721225
18Pentose phosphate pathway_Homo sapiens_hsa000301.81161595
19Fanconi anemia pathway_Homo sapiens_hsa034601.78934508
20mRNA surveillance pathway_Homo sapiens_hsa030151.78269549
21Purine metabolism_Homo sapiens_hsa002301.72575154
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.68577139
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66855905
24Ribosome_Homo sapiens_hsa030101.66106861
25p53 signaling pathway_Homo sapiens_hsa041151.64730283
26Pyruvate metabolism_Homo sapiens_hsa006201.58880484
27Oocyte meiosis_Homo sapiens_hsa041141.53672445
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.45533596
29Non-homologous end-joining_Homo sapiens_hsa034501.33098055
30Glycerophospholipid metabolism_Homo sapiens_hsa005641.30166878
31RNA degradation_Homo sapiens_hsa030181.27897780
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.27754523
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.27626077
34Epstein-Barr virus infection_Homo sapiens_hsa051691.27620192
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25636123
36One carbon pool by folate_Homo sapiens_hsa006701.23370825
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16285481
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12904110
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04258047
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02937090
41Fatty acid biosynthesis_Homo sapiens_hsa000610.98783972
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98093728
43Vitamin digestion and absorption_Homo sapiens_hsa049770.94776998
44Fructose and mannose metabolism_Homo sapiens_hsa000510.92269729
45Selenocompound metabolism_Homo sapiens_hsa004500.84699289
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81640912
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.80909827
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80493061
49Huntingtons disease_Homo sapiens_hsa050160.80165895
50Chronic myeloid leukemia_Homo sapiens_hsa052200.77131329
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.74849847
52Biosynthesis of amino acids_Homo sapiens_hsa012300.74002673
53Propanoate metabolism_Homo sapiens_hsa006400.70945985
54N-Glycan biosynthesis_Homo sapiens_hsa005100.69912663
55Arginine biosynthesis_Homo sapiens_hsa002200.69193299
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.62129400
57Olfactory transduction_Homo sapiens_hsa047400.62041955
58Acute myeloid leukemia_Homo sapiens_hsa052210.61273653
59Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60361259
60Glutathione metabolism_Homo sapiens_hsa004800.60177841
61Carbon metabolism_Homo sapiens_hsa012000.55934713
62Glycerolipid metabolism_Homo sapiens_hsa005610.54533756
63ErbB signaling pathway_Homo sapiens_hsa040120.53174045
64Herpes simplex infection_Homo sapiens_hsa051680.52713703
65Pancreatic cancer_Homo sapiens_hsa052120.50451241
66Sulfur metabolism_Homo sapiens_hsa009200.50320077
67Metabolic pathways_Homo sapiens_hsa011000.49839755
68Adherens junction_Homo sapiens_hsa045200.49511563
69Renin-angiotensin system_Homo sapiens_hsa046140.47036700
70Linoleic acid metabolism_Homo sapiens_hsa005910.44587162
71Phenylalanine metabolism_Homo sapiens_hsa003600.43961045
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43484155
73Alzheimers disease_Homo sapiens_hsa050100.41506283
74TGF-beta signaling pathway_Homo sapiens_hsa043500.41494222
75Parkinsons disease_Homo sapiens_hsa050120.41396386
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38916752
77Prion diseases_Homo sapiens_hsa050200.37292463
78Fatty acid metabolism_Homo sapiens_hsa012120.36108767
79Sulfur relay system_Homo sapiens_hsa041220.33542279
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33043615
81Viral carcinogenesis_Homo sapiens_hsa052030.31875057
82Caffeine metabolism_Homo sapiens_hsa002320.30599357
83Prostate cancer_Homo sapiens_hsa052150.30053072
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27967023
85Butanoate metabolism_Homo sapiens_hsa006500.27708788
86Renal cell carcinoma_Homo sapiens_hsa052110.27505820
87Bladder cancer_Homo sapiens_hsa052190.26205277
88beta-Alanine metabolism_Homo sapiens_hsa004100.25718802
89HTLV-I infection_Homo sapiens_hsa051660.25022279
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24926332
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.24585961
92Non-small cell lung cancer_Homo sapiens_hsa052230.24512810
93Shigellosis_Homo sapiens_hsa051310.23787325
94Small cell lung cancer_Homo sapiens_hsa052220.23655729
95MicroRNAs in cancer_Homo sapiens_hsa052060.23384929
96Insulin signaling pathway_Homo sapiens_hsa049100.23313523
97Arginine and proline metabolism_Homo sapiens_hsa003300.22813979
98Ether lipid metabolism_Homo sapiens_hsa005650.21580240
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20697113
100Colorectal cancer_Homo sapiens_hsa052100.20004406
101Tight junction_Homo sapiens_hsa045300.17755220
102Lysine degradation_Homo sapiens_hsa003100.17533626
103Hippo signaling pathway_Homo sapiens_hsa043900.17499585
104Apoptosis_Homo sapiens_hsa042100.17377986
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16650067
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16497456
107VEGF signaling pathway_Homo sapiens_hsa043700.16311621
108Tyrosine metabolism_Homo sapiens_hsa003500.16139709
109Lysosome_Homo sapiens_hsa041420.15888429
110Arachidonic acid metabolism_Homo sapiens_hsa005900.15480550
111FoxO signaling pathway_Homo sapiens_hsa040680.13319107
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.12339091
113Oxidative phosphorylation_Homo sapiens_hsa001900.11332746
114Legionellosis_Homo sapiens_hsa051340.09568068
115Circadian rhythm_Homo sapiens_hsa047100.09098180
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.08708028
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.08275070
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.07215687
119Steroid biosynthesis_Homo sapiens_hsa001000.04345360
120Fat digestion and absorption_Homo sapiens_hsa049750.03063834
121Collecting duct acid secretion_Homo sapiens_hsa049660.03007647
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.02367294
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.02303914
124Hedgehog signaling pathway_Homo sapiens_hsa043400.01477882
125Antigen processing and presentation_Homo sapiens_hsa046120.01430619
126Sphingolipid metabolism_Homo sapiens_hsa006000.00273005
127Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.00051216
128Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0576308
129Taurine and hypotaurine metabolism_Homo sapiens_hsa00430-0.0562851
130Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0493959
131mTOR signaling pathway_Homo sapiens_hsa04150-0.0492878
132Fatty acid elongation_Homo sapiens_hsa00062-0.0485419
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0455199
134Thyroid cancer_Homo sapiens_hsa05216-0.0379681
135Mineral absorption_Homo sapiens_hsa04978-0.0319251
136Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0157091
137Protein export_Homo sapiens_hsa03060-0.0136885
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0129849
139Influenza A_Homo sapiens_hsa05164-0.0129529
140Steroid hormone biosynthesis_Homo sapiens_hsa00140-0.0010750

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