MAGEB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEB genes are clustered on chromosome Xp22-p21. This gene sequence ends in the first intron of MAGEB1, another family member. This gene is expressed in testis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis (GO:0007140)9.24067406
2chromosome organization involved in meiosis (GO:0070192)8.33331824
3meiotic nuclear division (GO:0007126)8.31574980
4positive regulation of meiosis (GO:0045836)7.44852783
5meiotic chromosome segregation (GO:0045132)7.10152068
6positive regulation of meiotic cell cycle (GO:0051446)6.92907929
7male meiosis I (GO:0007141)6.79688153
8oogenesis (GO:0048477)6.54147202
9gene silencing by RNA (GO:0031047)6.42411015
10DNA alkylation (GO:0006305)6.30125085
11DNA methylation (GO:0006306)6.30125085
12reciprocal DNA recombination (GO:0035825)6.18596612
13reciprocal meiotic recombination (GO:0007131)6.18596612
14meiotic cell cycle process (GO:1903046)5.78308550
15meiosis I (GO:0007127)5.67185054
16attachment of spindle microtubules to kinetochore (GO:0008608)5.50514041
17positive regulation of translational initiation (GO:0045948)5.40841290
18negative regulation of meiosis (GO:0045835)5.29483538
19heterochromatin organization (GO:0070828)5.28237091
20nuclear pore organization (GO:0006999)5.20262050
21resolution of meiotic recombination intermediates (GO:0000712)5.07823184
22nuclear pore complex assembly (GO:0051292)5.04520058
23oocyte development (GO:0048599)4.90261847
24DNA synthesis involved in DNA repair (GO:0000731)4.88749072
25DNA methylation or demethylation (GO:0044728)4.85374875
26oocyte maturation (GO:0001556)4.75706730
27female gamete generation (GO:0007292)4.70238263
28sister chromatid cohesion (GO:0007062)4.69786264
29gene silencing (GO:0016458)4.69298937
30DNA replication checkpoint (GO:0000076)4.59909873
31synapsis (GO:0007129)4.51421062
32histone H4-K12 acetylation (GO:0043983)4.33878372
33kinetochore organization (GO:0051383)4.33852967
34positive regulation of male gonad development (GO:2000020)4.23881462
35mitotic chromosome condensation (GO:0007076)4.13558505
36kinetochore assembly (GO:0051382)4.12632848
37regulation of meiosis (GO:0040020)4.11216063
38sex differentiation (GO:0007548)4.10477820
39DNA modification (GO:0006304)3.99527203
40regulation of double-strand break repair via homologous recombination (GO:0010569)3.85363834
41protein K6-linked ubiquitination (GO:0085020)3.75600802
42pore complex assembly (GO:0046931)3.68286304
43mitotic spindle assembly checkpoint (GO:0007094)3.63921348
44regulation of male gonad development (GO:2000018)3.59399905
45spindle assembly checkpoint (GO:0071173)3.56413990
46germ cell development (GO:0007281)3.51719392
47regulation of gene silencing by RNA (GO:0060966)3.51664413
48regulation of posttranscriptional gene silencing (GO:0060147)3.51664413
49regulation of gene silencing by miRNA (GO:0060964)3.51664413
50DNA replication-dependent nucleosome assembly (GO:0006335)3.50716280
51DNA replication-dependent nucleosome organization (GO:0034723)3.50716280
52mitotic spindle checkpoint (GO:0071174)3.49231223
53negative regulation of chromosome segregation (GO:0051985)3.46033420
54negative regulation of mitotic sister chromatid segregation (GO:0033048)3.43289799
55negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.43289799
56negative regulation of sister chromatid segregation (GO:0033046)3.43289799
57negative regulation of mitotic sister chromatid separation (GO:2000816)3.43289799
58male sex determination (GO:0030238)3.42773736
59inner cell mass cell proliferation (GO:0001833)3.41111920
60regulation of double-strand break repair (GO:2000779)3.40925634
61chromatin remodeling at centromere (GO:0031055)3.40426842
62regulation of meiotic cell cycle (GO:0051445)3.34898968
63chromosome organization (GO:0051276)3.33092863
64negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.31516267
65mRNA export from nucleus (GO:0006406)3.29570978
66regulation of mitotic metaphase/anaphase transition (GO:0030071)3.24912813
67negative regulation of nuclear division (GO:0051784)3.21887417
68spindle checkpoint (GO:0031577)3.21564287
69germ cell migration (GO:0008354)3.21332158
70pre-miRNA processing (GO:0031054)3.19895849
71histone H4-K5 acetylation (GO:0043981)3.19421204
72histone H4-K8 acetylation (GO:0043982)3.19421204
73negative regulation of meiotic cell cycle (GO:0051447)3.19385592
74metaphase plate congression (GO:0051310)3.18760125
75regulation of sister chromatid segregation (GO:0033045)3.18601743
76regulation of mitotic sister chromatid separation (GO:0010965)3.18601743
77regulation of mitotic sister chromatid segregation (GO:0033047)3.18601743
78regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.16232743
79RNA export from nucleus (GO:0006405)3.14887318
80maturation of SSU-rRNA (GO:0030490)3.12646856
81regulation of chromosome segregation (GO:0051983)3.12342070
82snRNA processing (GO:0016180)3.11966248
83DNA unwinding involved in DNA replication (GO:0006268)3.09830236
84nuclear division (GO:0000280)3.09068320
85histone H3-K9 methylation (GO:0051567)3.05183227
86negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.04712719
87regulation of histone H3-K9 methylation (GO:0051570)3.04408177
88mitotic sister chromatid cohesion (GO:0007064)3.02841382
89meiotic cell cycle (GO:0051321)3.00075550
90snRNA metabolic process (GO:0016073)2.94737128
91histone exchange (GO:0043486)2.93916842
92mitotic nuclear envelope disassembly (GO:0007077)2.89673109
93regulation of RNA export from nucleus (GO:0046831)2.88000717
94regulation of mitotic spindle checkpoint (GO:1903504)2.87747054
95regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.87747054
96piRNA metabolic process (GO:0034587)15.7726894
97DNA methylation involved in gamete generation (GO:0043046)13.0580398
98synaptonemal complex assembly (GO:0007130)11.8394529
99synaptonemal complex organization (GO:0070193)10.7370701
100regulation of meiosis I (GO:0060631)10.4981483

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.47020863
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.18728100
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.78434272
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.16990084
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.90898605
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.53341440
7KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.40812644
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.21804556
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.21804556
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.21804556
11AR_21909140_ChIP-Seq_LNCAP_Human3.00254848
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.97189850
13HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.90437702
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.77686801
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.54206546
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.51989035
17MYCN_18555785_ChIP-Seq_MESCs_Mouse2.42010816
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.36213050
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29016878
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19727185
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.16976738
22CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.02448834
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00194315
24MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99415981
25YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99147323
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.97285080
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.91160733
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90636157
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.90058991
30ZFX_18555785_ChIP-Seq_MESCs_Mouse1.89849511
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84986530
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.83203029
33RNF2_27304074_Chip-Seq_NSC_Mouse1.80587387
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.77523247
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.75686557
36XRN2_22483619_ChIP-Seq_HELA_Human1.73542616
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.67622500
38KDM5A_27292631_Chip-Seq_BREAST_Human1.67497082
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.63044134
40DCP1A_22483619_ChIP-Seq_HELA_Human1.60788547
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.59669827
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56084380
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53423041
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52999512
45VDR_23849224_ChIP-Seq_CD4+_Human1.49021440
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.45240339
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40928091
48GABP_19822575_ChIP-Seq_HepG2_Human1.35472918
49CIITA_25753668_ChIP-Seq_RAJI_Human1.33525039
50RUNX1_26923725_Chip-Seq_HPCs_Mouse1.32683042
51CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30569274
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29090001
53E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.26793490
54GATA1_26923725_Chip-Seq_HPCs_Mouse1.26242773
55FOXP3_21729870_ChIP-Seq_TREG_Human1.20977812
56TTF2_22483619_ChIP-Seq_HELA_Human1.20129850
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19376505
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17047698
59CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12023399
60TFEB_21752829_ChIP-Seq_HELA_Human1.11956197
61PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10458659
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07284107
63GATA1_22025678_ChIP-Seq_K562_Human1.06551270
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.02695121
65ELK1_19687146_ChIP-ChIP_HELA_Human0.96934147
66MYC_18940864_ChIP-ChIP_HL60_Human0.95513639
67NOTCH1_21737748_ChIP-Seq_TLL_Human0.92068640
68HTT_18923047_ChIP-ChIP_STHdh_Human0.90828432
69REST_19997604_ChIP-ChIP_NEURONS_Mouse0.88992927
70SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82649851
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.82223856
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.77038374
73ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76109467
74EWS_26573619_Chip-Seq_HEK293_Human0.74938472
75YY1_21170310_ChIP-Seq_MESCs_Mouse0.74068983
76CHD1_26751641_Chip-Seq_LNCaP_Human0.73991414
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.73193296
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.72939314
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.72924605
80FUS_26573619_Chip-Seq_HEK293_Human0.71264007
81HOXB7_26014856_ChIP-Seq_BT474_Human0.70803887
82DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.69784755
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.69637787
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.68895059
85OCT4_19829295_ChIP-Seq_ESCs_Human0.68833454
86SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.67668252
87TBX5_21415370_ChIP-Seq_HL-1_Mouse0.67634031
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.67433227
89HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.67250792
90TET1_21490601_ChIP-Seq_MESCs_Mouse0.66790254
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.66774507
92HOXB4_20404135_ChIP-ChIP_EML_Mouse0.64011349
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.60025159
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.55715862
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.55652777
96PKCTHETA_26484144_Chip-Seq_BREAST_Human0.54902919
97NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.54551634
98SOX2_21211035_ChIP-Seq_LN229_Human0.53743455
99SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.53647139
100FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.53380500

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence7.32370922
2MP0002210_abnormal_sex_determination4.61901169
3MP0003786_premature_aging4.43292666
4MP0010094_abnormal_chromosome_stability3.95772162
5MP0001145_abnormal_male_reproductive3.67766064
6MP0001929_abnormal_gametogenesis3.65924305
7MP0008058_abnormal_DNA_repair3.56522962
8MP0003123_paternal_imprinting3.41585862
9MP0000653_abnormal_sex_gland3.28390106
10MP0008057_abnormal_DNA_replication3.10472010
11MP0003111_abnormal_nucleus_morphology2.83229734
12MP0003698_abnormal_male_reproductive2.83050269
13MP0004957_abnormal_blastocyst_morpholog2.44475269
14MP0003077_abnormal_cell_cycle2.37240867
15MP0003693_abnormal_embryo_hatching2.24785829
16MP0008877_abnormal_DNA_methylation11.1418957
17MP0003121_genomic_imprinting1.86991959
18MP0001730_embryonic_growth_arrest1.70546851
19MP0001119_abnormal_female_reproductive1.66590487
20MP0003890_abnormal_embryonic-extraembry1.63020610
21MP0002161_abnormal_fertility/fecundity1.62389574
22MP0010352_gastrointestinal_tract_polyps1.59431916
23MP0008007_abnormal_cellular_replicative1.59295851
24MP0008932_abnormal_embryonic_tissue1.53965360
25MP0004808_abnormal_hematopoietic_stem1.47908663
26MP0000350_abnormal_cell_proliferation1.43211177
27MP0010307_abnormal_tumor_latency1.41200650
28MP0003787_abnormal_imprinting1.16366226
29MP0004197_abnormal_fetal_growth/weight/1.15171966
30MP0005076_abnormal_cell_differentiation1.10195977
31MP0003699_abnormal_female_reproductive1.08147875
32MP0009672_abnormal_birth_weight1.02332026
33MP0005380_embryogenesis_phenotype1.00872085
34MP0001672_abnormal_embryogenesis/_devel1.00872085
35MP0002085_abnormal_embryonic_tissue0.99370145
36MP0001697_abnormal_embryo_size0.97639479
37MP0003878_abnormal_ear_physiology0.97591035
38MP0005377_hearing/vestibular/ear_phenot0.97591035
39MP0005623_abnormal_meninges_morphology0.97411223
40MP0003984_embryonic_growth_retardation0.95127856
41MP0003941_abnormal_skin_development0.95117013
42MP0000313_abnormal_cell_death0.92184061
43MP0002160_abnormal_reproductive_system0.90765778
44MP0002084_abnormal_developmental_patter0.90707004
45MP0002088_abnormal_embryonic_growth/wei0.88511272
46MP0002019_abnormal_tumor_incidence0.81569460
47MP0003936_abnormal_reproductive_system0.81202198
48MP0002080_prenatal_lethality0.80635733
49MP0002086_abnormal_extraembryonic_tissu0.74327804
50MP0003315_abnormal_perineum_morphology0.74219345
51MP0005647_abnormal_sex_gland0.73124520
52MP0001915_intracranial_hemorrhage0.68224652
53MP0009703_decreased_birth_body0.66832076
54MP0003567_abnormal_fetal_cardiomyocyte0.61917506
55MP0001293_anophthalmia0.57416383
56MP0003937_abnormal_limbs/digits/tail_de0.57071535
57MP0003119_abnormal_digestive_system0.55837454
58MP0000427_abnormal_hair_cycle0.55649778
59MP0000537_abnormal_urethra_morphology0.55256027
60MP0003705_abnormal_hypodermis_morpholog0.54401197
61MP0003221_abnormal_cardiomyocyte_apopto0.51456875
62MP0005621_abnormal_cell_physiology0.51164129
63MP0002697_abnormal_eye_size0.50492578
64MP0005410_abnormal_fertilization0.48814417
65MP0003632_abnormal_nervous_system0.48302378
66MP0000383_abnormal_hair_follicle0.47699216
67MP0005384_cellular_phenotype0.46387085
68MP0002009_preneoplasia0.44709261
69MP0003943_abnormal_hepatobiliary_system0.43078146
70MP0003861_abnormal_nervous_system0.42023114
71MP0004185_abnormal_adipocyte_glucose0.40903914
72MP0000569_abnormal_digit_pigmentation0.40750102
73MP0005389_reproductive_system_phenotype0.40712475
74MP0002269_muscular_atrophy0.40440054
75MP0010678_abnormal_skin_adnexa0.40170420
76MP0003115_abnormal_respiratory_system0.39276340
77MP0002075_abnormal_coat/hair_pigmentati0.38718576
78MP0003718_maternal_effect0.38557765
79MP0002751_abnormal_autonomic_nervous0.37219519
80MP0001177_atelectasis0.36429755
81MP0002092_abnormal_eye_morphology0.35802653
82MP0005171_absent_coat_pigmentation0.33598151
83MP0004233_abnormal_muscle_weight0.33065306
84MP0001727_abnormal_embryo_implantation0.31379669
85MP0000703_abnormal_thymus_morphology0.30726860
86MP0009053_abnormal_anal_canal0.30301499
87MP0001661_extended_life_span0.29378483
88MP0002111_abnormal_tail_morphology0.28069364
89MP0000428_abnormal_craniofacial_morphol0.27793335
90MP0000432_abnormal_head_morphology0.26057113
91MP0009697_abnormal_copulation0.24744962
92MP0003755_abnormal_palate_morphology0.24111801
93MP0001186_pigmentation_phenotype0.22805512
94MP0002396_abnormal_hematopoietic_system0.20817326
95MP0005248_abnormal_Harderian_gland0.20318360
96MP0000534_abnormal_ureter_morphology0.20137984
97MP0009278_abnormal_bone_marrow0.19442109
98MP0009765_abnormal_xenobiotic_induced0.19313502
99MP0003566_abnormal_cell_adhesion0.18739006
100MP0003935_abnormal_craniofacial_develop0.18557474

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.27385586
2Abnormality of the lower motor neuron (HP:0002366)5.22881059
3Gonadotropin excess (HP:0000837)5.17662836
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.90487145
5Papillary thyroid carcinoma (HP:0002895)3.91061901
6Facial hemangioma (HP:0000329)3.78906969
711 pairs of ribs (HP:0000878)3.65942714
8Colon cancer (HP:0003003)3.53812077
9Duplicated collecting system (HP:0000081)3.38270227
10Abnormality of the labia minora (HP:0012880)3.33453047
11Ectopic kidney (HP:0000086)3.28162993
12Shoulder girdle muscle weakness (HP:0003547)3.12730683
13Medulloblastoma (HP:0002885)3.06483654
14Abnormality of chromosome stability (HP:0003220)2.99831530
15Absent thumb (HP:0009777)2.99333475
16Carpal bone hypoplasia (HP:0001498)2.95170119
17Rhabdomyosarcoma (HP:0002859)2.88854182
18Spontaneous abortion (HP:0005268)2.79936156
19Amyotrophic lateral sclerosis (HP:0007354)2.76549609
20Metaphyseal cupping (HP:0003021)2.74918929
21Ankle contracture (HP:0006466)2.74611247
22Upper motor neuron abnormality (HP:0002127)2.74011895
23Abnormality of the renal collecting system (HP:0004742)2.71326463
24Impulsivity (HP:0100710)2.67412340
25Capillary hemangiomas (HP:0005306)2.65549992
26Ependymoma (HP:0002888)2.54945372
27Thyroid carcinoma (HP:0002890)2.53611185
28Hand muscle atrophy (HP:0009130)2.49607533
29Abnormality of the aortic arch (HP:0012303)2.44876836
30Absent radius (HP:0003974)2.42849844
31Meckel diverticulum (HP:0002245)2.41975018
32Abnormality of homocysteine metabolism (HP:0010919)2.41950035
33Homocystinuria (HP:0002156)2.41950035
34Reticulocytopenia (HP:0001896)2.38394132
35Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.37637141
36Neoplasm of striated muscle (HP:0009728)2.36109512
37Pelvic girdle muscle weakness (HP:0003749)2.33243824
38Abnormality of the astrocytes (HP:0100707)2.32856989
39Astrocytoma (HP:0009592)2.32856989
40Aplasia involving forearm bones (HP:0009822)2.32141491
41Absent forearm bone (HP:0003953)2.32141491
42Breast hypoplasia (HP:0003187)2.31193468
43Fibular hypoplasia (HP:0003038)2.28866152
44Glioma (HP:0009733)2.26559107
45Short thumb (HP:0009778)2.25073016
46Abnormality of the fingertips (HP:0001211)2.24479763
47Shawl scrotum (HP:0000049)2.22619127
48Selective tooth agenesis (HP:0001592)2.22196997
49Short tibia (HP:0005736)2.22118916
50Urethral obstruction (HP:0000796)2.21332444
51Abnormality of the ileum (HP:0001549)2.21024234
52Biliary tract neoplasm (HP:0100574)2.20210139
53Abnormal biliary tract morphology (HP:0012440)2.18689563
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.18209450
55Increased nuchal translucency (HP:0010880)2.16878935
56Volvulus (HP:0002580)2.16784115
57Abnormal lung lobation (HP:0002101)2.16283278
58Sandal gap (HP:0001852)2.14806883
59Atrophy/Degeneration involving motor neurons (HP:0007373)2.13365994
60Long eyelashes (HP:0000527)2.12549074
61Proximal placement of thumb (HP:0009623)2.12143412
62Relative macrocephaly (HP:0004482)2.11729758
63Progressive external ophthalmoplegia (HP:0000590)2.10919895
64Limb-girdle muscle weakness (HP:0003325)2.10801840
65Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.10617169
66Short 4th metacarpal (HP:0010044)2.10617169
67Birth length less than 3rd percentile (HP:0003561)2.07959947
68Heterotopia (HP:0002282)2.04796416
69Male pseudohermaphroditism (HP:0000037)2.04732102
70Missing ribs (HP:0000921)2.04418293
71Obstructive sleep apnea (HP:0002870)2.03977122
72Basal cell carcinoma (HP:0002671)2.00354907
73Azoospermia (HP:0000027)12.1120748
74Abnormal spermatogenesis (HP:0008669)10.2257228
75Facial cleft (HP:0002006)1.99492877
76Truncal obesity (HP:0001956)1.98619621
77Abnormality of the preputium (HP:0100587)1.98295997
78Broad palm (HP:0001169)1.96679722
79Abnormality of the musculature of the pelvis (HP:0001469)1.95193237
80Abnormality of the hip-girdle musculature (HP:0001445)1.95193237
81Small intestinal stenosis (HP:0012848)1.94730332
82Duodenal stenosis (HP:0100867)1.94730332
83Horseshoe kidney (HP:0000085)1.93542315
84Cafe-au-lait spot (HP:0000957)1.92913869
85Spinal muscular atrophy (HP:0007269)1.92149595
86Deviation of the thumb (HP:0009603)1.91659113
87Rectal fistula (HP:0100590)1.91556501
88Rectovaginal fistula (HP:0000143)1.91556501
89Abnormality of DNA repair (HP:0003254)1.90841312
90Ureteral duplication (HP:0000073)1.90037651
91Abnormality of pyrimidine metabolism (HP:0004353)1.89861624
92Abnormality of the phalanges of the hallux (HP:0010057)1.88619827
93Aplasia/Hypoplasia of the tibia (HP:0005772)1.88399675
94Intestinal fistula (HP:0100819)1.86747803
95Upper limb amyotrophy (HP:0009129)1.86225696
96Distal upper limb amyotrophy (HP:0007149)1.86225696
97Abnormality of the carotid arteries (HP:0005344)1.85724055
98Oligodactyly (HP:0012165)1.85288675
99Abnormality of the musculature of the hand (HP:0001421)1.80521158
100Patellar aplasia (HP:0006443)1.78439895

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.83967603
2CDC76.33758325
3CDK126.07711060
4WEE12.84873895
5BRD42.63148447
6PBK2.43832186
7NEK22.32789719
8BRSK21.99818161
9PLK11.98694613
10ATR1.82066772
11MAP3K41.79429786
12CHEK11.67828000
13NEK11.64195442
14STK38L1.57905085
15MKNK21.50212432
16STK241.49126716
17BRSK11.45054388
18TTK1.42804035
19PLK41.39784029
20PDK31.39025820
21PDK41.39025820
22ATM1.37951311
23IRAK31.36481976
24CDK71.31513340
25MELK1.26820319
26CDC42BPA1.25760513
27BUB11.18934030
28PLK21.18897397
29SCYL21.13044153
30MAP3K21.11577756
31CDK41.07806311
32CAMK1D1.06061665
33CHEK21.05002609
34CDK80.99943051
35CLK10.98694232
36CDK20.97760509
37STK40.97478153
38PLK30.94569317
39BMPR1B0.93719015
40TGFBR10.93405739
41MKNK10.92665351
42PRKD30.91392765
43CDK10.90137574
44TYRO30.89496903
45STK30.88033997
46AURKB0.85779246
47SRPK10.83032781
48MTOR0.77330406
49DYRK30.70482817
50CDK90.69468170
51IRAK20.68447693
52TSSK60.66073214
53BCR0.64617269
54PRKDC0.64109207
55ZAK0.63381843
56IRAK10.62210550
57NME10.62166151
58PKN20.58063364
59DYRK1A0.55566440
60GSK3B0.55277493
61PDK20.55250100
62PASK0.54646039
63MAP3K30.52898989
64LIMK10.50870138
65CSNK1D0.48245650
66ALK0.47878178
67WNK30.46536672
68PAK40.46430265
69KSR10.46325276
70WNK10.46233036
71CSNK2A20.45788621
72MAP2K40.44380198
73ICK0.44126559
74MAPK80.43524067
75MAP3K60.42909278
76CSNK1E0.41622445
77MAPK110.39980753
78AURKA0.39884081
79CCNB10.39600317
80MAPK140.39334913
81MARK30.37890553
82RPS6KB10.35930332
83CSNK1A1L0.35682888
84MAP3K90.33672582
85CSNK1G10.32819810
86EIF2AK10.32118937
87CHUK0.31954733
88RET0.31091998
89CAMK1G0.29483459
90CDK60.29022314
91PRKCI0.28943354
92RPS6KB20.28409795
93MET0.28371981
94MARK10.28262432
95AKT10.26885006
96PTK2B0.26355869
97CSNK2A10.25926548
98TLK10.23482186
99CAMK40.22505916
100STK160.22184042

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030085.99779256
2Basal transcription factors_Homo sapiens_hsa030224.91882937
3DNA replication_Homo sapiens_hsa030304.02904792
4Mismatch repair_Homo sapiens_hsa034304.00819609
5Homologous recombination_Homo sapiens_hsa034403.78278356
6RNA transport_Homo sapiens_hsa030133.22014068
7mRNA surveillance pathway_Homo sapiens_hsa030153.09541174
8Cell cycle_Homo sapiens_hsa041103.05434902
9RNA polymerase_Homo sapiens_hsa030203.02700069
10Spliceosome_Homo sapiens_hsa030402.88451526
11Fanconi anemia pathway_Homo sapiens_hsa034602.72805268
12Nucleotide excision repair_Homo sapiens_hsa034202.71598258
13Selenocompound metabolism_Homo sapiens_hsa004502.65996199
14Proteasome_Homo sapiens_hsa030502.60641527
15One carbon pool by folate_Homo sapiens_hsa006702.37209782
16Base excision repair_Homo sapiens_hsa034102.26012971
17Non-homologous end-joining_Homo sapiens_hsa034502.23179839
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.20210813
19RNA degradation_Homo sapiens_hsa030181.92761633
20Oocyte meiosis_Homo sapiens_hsa041141.83333817
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.82688356
22Dorso-ventral axis formation_Homo sapiens_hsa043201.57960614
23Pyrimidine metabolism_Homo sapiens_hsa002401.54593474
24Lysine degradation_Homo sapiens_hsa003101.49775722
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.46212523
26Herpes simplex infection_Homo sapiens_hsa051681.36552052
27Thyroid cancer_Homo sapiens_hsa052161.36227181
28Epstein-Barr virus infection_Homo sapiens_hsa051691.14092757
29p53 signaling pathway_Homo sapiens_hsa041151.02973539
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01765152
31Purine metabolism_Homo sapiens_hsa002301.01021990
32HTLV-I infection_Homo sapiens_hsa051660.78114747
33TGF-beta signaling pathway_Homo sapiens_hsa043500.77729161
34Influenza A_Homo sapiens_hsa051640.70299619
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66488700
36Viral carcinogenesis_Homo sapiens_hsa052030.62768797
37Huntingtons disease_Homo sapiens_hsa050160.62500359
38Notch signaling pathway_Homo sapiens_hsa043300.62409929
39MicroRNAs in cancer_Homo sapiens_hsa052060.57885787
40Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56233191
41Adherens junction_Homo sapiens_hsa045200.55183073
42Glycerolipid metabolism_Homo sapiens_hsa005610.50713605
43Pentose phosphate pathway_Homo sapiens_hsa000300.50440118
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49552628
45Hippo signaling pathway_Homo sapiens_hsa043900.44815831
46Tight junction_Homo sapiens_hsa045300.43473502
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.41578790
48FoxO signaling pathway_Homo sapiens_hsa040680.37242463
49Biosynthesis of amino acids_Homo sapiens_hsa012300.36399759
50Small cell lung cancer_Homo sapiens_hsa052220.34193865
51Colorectal cancer_Homo sapiens_hsa052100.29680028
52Pancreatic cancer_Homo sapiens_hsa052120.28384129
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25425384
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24877963
55Ribosome_Homo sapiens_hsa030100.23260231
56Prostate cancer_Homo sapiens_hsa052150.22294798
57Pathways in cancer_Homo sapiens_hsa052000.22257579
58Antigen processing and presentation_Homo sapiens_hsa046120.18638529
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18329714
60Fatty acid biosynthesis_Homo sapiens_hsa000610.17742562
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.17249487
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15708037
63Glutathione metabolism_Homo sapiens_hsa004800.15289424
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.14421003
65Systemic lupus erythematosus_Homo sapiens_hsa053220.13606855
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12613269
67Renal cell carcinoma_Homo sapiens_hsa052110.10709751
68Basal cell carcinoma_Homo sapiens_hsa052170.09851006
69Wnt signaling pathway_Homo sapiens_hsa043100.08989258
70Hedgehog signaling pathway_Homo sapiens_hsa043400.07040468
71Non-small cell lung cancer_Homo sapiens_hsa052230.06662275
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.06592302
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.05383601
74ECM-receptor interaction_Homo sapiens_hsa045120.02546354
75HIF-1 signaling pathway_Homo sapiens_hsa040660.02435100
76Long-term potentiation_Homo sapiens_hsa047200.02103166
77Proteoglycans in cancer_Homo sapiens_hsa052050.01418924
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.00903268
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.00026942
80VEGF signaling pathway_Homo sapiens_hsa04370-0.1034646
81alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0979449
82Drug metabolism - other enzymes_Homo sapiens_hsa00983-0.0922156
83AMPK signaling pathway_Homo sapiens_hsa04152-0.0908916
84Pathogenic Escherichia coli infection_Homo sapiens_hsa05130-0.0899150
85Phosphatidylinositol signaling system_Homo sapiens_hsa04070-0.0849783
86Ether lipid metabolism_Homo sapiens_hsa00565-0.0709626
87Carbon metabolism_Homo sapiens_hsa01200-0.0695505
88Pyruvate metabolism_Homo sapiens_hsa00620-0.0655078
89Focal adhesion_Homo sapiens_hsa04510-0.0652573
90Axon guidance_Homo sapiens_hsa04360-0.0621191
91Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0429260
92Linoleic acid metabolism_Homo sapiens_hsa00591-0.0314769
93Glucagon signaling pathway_Homo sapiens_hsa04922-0.0282404
94Alcoholism_Homo sapiens_hsa05034-0.0281288
95Glioma_Homo sapiens_hsa05214-0.0220539
96Parkinsons disease_Homo sapiens_hsa05012-0.0179541
97Fatty acid metabolism_Homo sapiens_hsa01212-0.0149488
98Fat digestion and absorption_Homo sapiens_hsa04975-0.0085811
99mTOR signaling pathway_Homo sapiens_hsa04150-0.0052678
100Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0023683

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