MAGEC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the melanoma antigen gene (MAGE) family. The proteins of this family are tumor-specific antigens that can be recognized by autologous cytolytic T lymphocytes. This protein contains a large number of unique short repetitive sequences in front of the MAGE-homologous sequence, and therefore is about 800 aa longer than the other MAGE proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)9.47253724
2synapsis (GO:0007129)8.20783125
3melanin biosynthetic process (GO:0042438)7.95439617
4melanin metabolic process (GO:0006582)7.16324830
5chromosome organization involved in meiosis (GO:0070192)6.65111740
6nuclear pore complex assembly (GO:0051292)6.47471866
7secondary metabolite biosynthetic process (GO:0044550)6.38836178
8DNA synthesis involved in DNA repair (GO:0000731)6.14807768
9synaptonemal complex assembly (GO:0007130)5.76626625
10nuclear pore organization (GO:0006999)5.49603003
11male meiosis I (GO:0007141)5.25578899
12male meiosis (GO:0007140)5.08594260
13synaptonemal complex organization (GO:0070193)5.02214870
14DNA methylation involved in gamete generation (GO:0043046)4.98131048
15pore complex assembly (GO:0046931)4.87870340
16DNA unwinding involved in DNA replication (GO:0006268)4.82742040
17piRNA metabolic process (GO:0034587)4.69377564
18mitotic sister chromatid segregation (GO:0000070)4.68417518
19mitotic chromosome condensation (GO:0007076)4.66159962
20resolution of meiotic recombination intermediates (GO:0000712)4.62737929
21meiotic nuclear division (GO:0007126)4.62510670
22meiosis I (GO:0007127)4.53482758
23sister chromatid segregation (GO:0000819)4.47174733
24mitotic nuclear envelope disassembly (GO:0007077)4.37197030
25regulation of translational fidelity (GO:0006450)4.37024725
26meiotic chromosome segregation (GO:0045132)4.17162227
27nuclear envelope disassembly (GO:0051081)4.12180327
28membrane disassembly (GO:0030397)4.12180327
29sister chromatid cohesion (GO:0007062)4.03376949
30meiotic cell cycle process (GO:1903046)4.03294760
31DNA replication initiation (GO:0006270)4.01235961
32DNA strand elongation involved in DNA replication (GO:0006271)4.00061094
33oxygen transport (GO:0015671)3.97920245
34COPI coating of Golgi vesicle (GO:0048205)3.96379081
35Golgi transport vesicle coating (GO:0048200)3.96379081
36DNA replication checkpoint (GO:0000076)3.93453893
37proteasome assembly (GO:0043248)3.91913949
38DNA strand elongation (GO:0022616)3.87637645
39gas transport (GO:0015669)3.79904747
40pigment biosynthetic process (GO:0046148)3.79106412
41protoporphyrinogen IX metabolic process (GO:0046501)3.70925292
42telomere maintenance via semi-conservative replication (GO:0032201)3.67865518
43regulation of DNA endoreduplication (GO:0032875)3.59921340
44chromosome segregation (GO:0007059)3.50910196
45formation of translation preinitiation complex (GO:0001731)3.45721087
46DNA topological change (GO:0006265)3.43175441
47diterpenoid biosynthetic process (GO:0016102)3.42789580
48regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.40549948
49positive regulation of response to oxidative stress (GO:1902884)3.38432359
50positive regulation of cellular response to oxidative stress (GO:1900409)3.38432359
51regulation of RNA export from nucleus (GO:0046831)3.33601088
52regulation of early endosome to late endosome transport (GO:2000641)3.33500595
53DNA packaging (GO:0006323)3.33105894
54chromosome condensation (GO:0030261)3.31836360
55protein localization to kinetochore (GO:0034501)3.26740393
56regulation of sister chromatid cohesion (GO:0007063)3.21977820
57proline biosynthetic process (GO:0006561)3.21595003
58regulation of histone H3-K4 methylation (GO:0051569)3.19081391
59mitotic recombination (GO:0006312)3.17841002
60reciprocal DNA recombination (GO:0035825)3.17654377
61reciprocal meiotic recombination (GO:0007131)3.17654377
62mitotic metaphase plate congression (GO:0007080)3.14975067
63regulation of translational elongation (GO:0006448)3.14878085
64regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.14731223
65mitotic spindle checkpoint (GO:0071174)3.13806362
66regulation of chromosome segregation (GO:0051983)3.13320610
67regulation of histone H3-K27 methylation (GO:0061085)3.11746403
68mitotic spindle assembly checkpoint (GO:0007094)3.10626541
69protoporphyrinogen IX biosynthetic process (GO:0006782)3.10569838
70pigment metabolic process (GO:0042440)3.07597531
71spindle assembly checkpoint (GO:0071173)3.07022071
72regulation of mitotic spindle organization (GO:0060236)3.06882731
73negative regulation of chromosome segregation (GO:0051985)3.06215384
74telomere maintenance via recombination (GO:0000722)3.04481911
75mitotic sister chromatid cohesion (GO:0007064)3.04117823
76spindle checkpoint (GO:0031577)3.02562567
77protein export from nucleus (GO:0006611)3.01251549
78tRNA aminoacylation for protein translation (GO:0006418)2.98638562
79protein localization to chromosome, centromeric region (GO:0071459)2.98583795
80negative regulation of mitotic sister chromatid separation (GO:2000816)2.98238961
81negative regulation of sister chromatid segregation (GO:0033046)2.98238961
82negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.98238961
83negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.98238961
84negative regulation of mitotic sister chromatid segregation (GO:0033048)2.98238961
85IMP biosynthetic process (GO:0006188)2.96989633
86nuclear envelope organization (GO:0006998)2.95099093
87chromosome organization (GO:0051276)2.93752346
88protein localization to chromosome (GO:0034502)2.91999397
89histone exchange (GO:0043486)2.90309600
90tricarboxylic acid cycle (GO:0006099)2.86728907
91terpenoid biosynthetic process (GO:0016114)2.86000352
92amino acid activation (GO:0043038)2.84988366
93tRNA aminoacylation (GO:0043039)2.84988366
94ribosome assembly (GO:0042255)2.83116997
95intra-S DNA damage checkpoint (GO:0031573)2.81677292
96positive regulation of DNA-dependent DNA replication (GO:2000105)2.80676931
97purine nucleobase biosynthetic process (GO:0009113)2.79773267
98gene silencing by RNA (GO:0031047)2.78687302
99regulation of sister chromatid segregation (GO:0033045)2.77971871
100regulation of mitotic sister chromatid segregation (GO:0033047)2.77971871

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.51038470
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.38110066
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.71888786
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.58203363
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.55333263
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.25460565
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.21832766
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.09126479
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.00265903
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53316312
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.51906910
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51011978
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38734919
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.32046248
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30184659
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.28296601
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.27263394
18XRN2_22483619_ChIP-Seq_HELA_Human2.26123806
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.24859271
20DCP1A_22483619_ChIP-Seq_HELA_Human2.16712560
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.14993850
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.10323440
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.07615036
24MYCN_18555785_ChIP-Seq_MESCs_Mouse2.01548154
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.00194890
26AR_21909140_ChIP-Seq_LNCAP_Human1.96779086
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96496208
28NCOR1_26117541_ChIP-Seq_K562_Human1.93006086
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92010893
30TTF2_22483619_ChIP-Seq_HELA_Human1.90690094
31ZFX_18555785_ChIP-Seq_MESCs_Mouse1.89871493
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89420563
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.86082470
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85309274
35GABP_19822575_ChIP-Seq_HepG2_Human1.73838034
36CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.66647650
37CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.64783769
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64017823
39CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62707880
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.62380208
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58150302
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.55699771
43TFEB_21752829_ChIP-Seq_HELA_Human1.55535241
44KDM5A_27292631_Chip-Seq_BREAST_Human1.55111096
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51462102
46CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.49717774
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48825930
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43959825
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43805524
50FOXP3_21729870_ChIP-Seq_TREG_Human1.41572843
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40889822
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40563665
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.39074626
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34633421
55VDR_23849224_ChIP-Seq_CD4+_Human1.34180385
56ELK1_19687146_ChIP-ChIP_HELA_Human1.33825521
57CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.31941305
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31730427
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30108911
60GATA1_19941826_ChIP-Seq_K562_Human1.28819335
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28103352
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24726437
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21123140
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20634161
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19867447
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19360727
67ZNF263_19887448_ChIP-Seq_K562_Human1.18067363
68GATA1_22025678_ChIP-Seq_K562_Human1.17013535
69HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13904773
70GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.13750464
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13087697
72MYC_22102868_ChIP-Seq_BL_Human1.11305424
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10625458
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10036051
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09048187
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07753320
77TBX5_21415370_ChIP-Seq_HL-1_Mouse1.06072086
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05760986
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04688697
80E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03450951
81CIITA_25753668_ChIP-Seq_RAJI_Human1.02929704
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99750508
83ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96263470
84GATA2_19941826_ChIP-Seq_K562_Human0.95940917
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92361687
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91099170
87TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.90411525
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89225431
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.88466134
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85313986
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.85172992
92CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.81849537
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80821454
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.80593905
95GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79381715
96SOX17_20123909_ChIP-Seq_XEN_Mouse0.76617650
97ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.75069560
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.73736113
99NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.73422898
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.73255888

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation7.94585232
2MP0005171_absent_coat_pigmentation5.10433943
3MP0005408_hypopigmentation4.56831759
4MP0003136_yellow_coat_color4.25761233
5MP0010094_abnormal_chromosome_stability3.52816348
6MP0008058_abnormal_DNA_repair3.46005149
7MP0003111_abnormal_nucleus_morphology3.36444392
8MP0002877_abnormal_melanocyte_morpholog3.14658152
9MP0004957_abnormal_blastocyst_morpholog2.79616797
10MP0004147_increased_porphyrin_level2.78087028
11MP0000015_abnormal_ear_pigmentation2.72315073
12MP0002095_abnormal_skin_pigmentation2.66109486
13MP0005075_abnormal_melanosome_morpholog2.63321413
14MP0003693_abnormal_embryo_hatching2.55481213
15MP0003077_abnormal_cell_cycle2.31839859
16MP0000678_abnormal_parathyroid_gland2.19843017
17MP0000371_diluted_coat_color2.12588670
18MP0008932_abnormal_embryonic_tissue2.05956951
19MP0008007_abnormal_cellular_replicative1.95113217
20MP0008995_early_reproductive_senescence1.93501143
21MP0005451_abnormal_body_composition1.90969478
22MP0003806_abnormal_nucleotide_metabolis1.90076984
23MP0008057_abnormal_DNA_replication1.88407275
24MP0002938_white_spotting1.85798622
25MP0002210_abnormal_sex_determination1.83066723
26MP0004381_abnormal_hair_follicle1.79097237
27MP0003656_abnormal_erythrocyte_physiolo1.75422903
28MP0003786_premature_aging1.66980901
29MP0001929_abnormal_gametogenesis1.62981891
30MP0005058_abnormal_lysosome_morphology1.61617599
31MP0009697_abnormal_copulation1.60550786
32MP0004233_abnormal_muscle_weight1.54633064
33MP0008877_abnormal_DNA_methylation1.53953505
34MP0005174_abnormal_tail_pigmentation1.53853159
35MP0002075_abnormal_coat/hair_pigmentati1.45835180
36MP0003646_muscle_fatigue1.40400633
37MP0003718_maternal_effect1.36722241
38MP0000350_abnormal_cell_proliferation1.35698534
39MP0001186_pigmentation_phenotype1.33991475
40MP0003950_abnormal_plasma_membrane1.33296539
41MP0003698_abnormal_male_reproductive1.30491261
42MP0006036_abnormal_mitochondrial_physio1.29706682
43MP0001730_embryonic_growth_arrest1.29041578
44MP0010307_abnormal_tumor_latency1.25696082
45MP0001145_abnormal_male_reproductive1.25524170
46MP0001697_abnormal_embryo_size1.24708943
47MP0001324_abnormal_eye_pigmentation1.24328985
48MP0003186_abnormal_redox_activity1.17192662
49MP0002396_abnormal_hematopoietic_system1.15947411
50MP0000653_abnormal_sex_gland1.15781548
51MP0002080_prenatal_lethality1.10116718
52MP0005380_embryogenesis_phenotype1.05028955
53MP0001672_abnormal_embryogenesis/_devel1.05028955
54MP0000313_abnormal_cell_death1.04135547
55MP0000358_abnormal_cell_content/1.03077062
56MP0001661_extended_life_span0.95444295
57MP0003699_abnormal_female_reproductive0.94554928
58MP0003984_embryonic_growth_retardation0.89213444
59MP0002161_abnormal_fertility/fecundity0.88863423
60MP0005257_abnormal_intraocular_pressure0.88626620
61MP0002269_muscular_atrophy0.85668704
62MP0002088_abnormal_embryonic_growth/wei0.84508928
63MP0001545_abnormal_hematopoietic_system0.84306542
64MP0005397_hematopoietic_system_phenotyp0.84306542
65MP0002102_abnormal_ear_morphology0.79365054
66MP0005410_abnormal_fertilization0.79118275
67MP0006035_abnormal_mitochondrial_morpho0.78082525
68MP0004808_abnormal_hematopoietic_stem0.77725204
69MP0002085_abnormal_embryonic_tissue0.75744617
70MP0001119_abnormal_female_reproductive0.75509995
71MP0002086_abnormal_extraembryonic_tissu0.74833358
72MP0002090_abnormal_vision0.73770243
73MP0002084_abnormal_developmental_patter0.71663628
74MP0002019_abnormal_tumor_incidence0.71421246
75MP0002132_abnormal_respiratory_system0.70538968
76MP0005187_abnormal_penis_morphology0.69721203
77MP0009672_abnormal_birth_weight0.69421029
78MP0004885_abnormal_endolymph0.68096085
79MP0003567_abnormal_fetal_cardiomyocyte0.64696542
80MP0001188_hyperpigmentation0.64563478
81MP0003172_abnormal_lysosome_physiology0.62720118
82MP0005083_abnormal_biliary_tract0.62118281
83MP0003959_abnormal_lean_body0.61463695
84MP0003878_abnormal_ear_physiology0.57712284
85MP0005377_hearing/vestibular/ear_phenot0.57712284
86MP0003123_paternal_imprinting0.57414922
87MP0004197_abnormal_fetal_growth/weight/0.56757970
88MP0005384_cellular_phenotype0.53615129
89MP0000749_muscle_degeneration0.53585201
90MP0001915_intracranial_hemorrhage0.53291007
91MP0008770_decreased_survivor_rate0.52929565
92MP0008438_abnormal_cutaneous_collagen0.50713793
93MP0000647_abnormal_sebaceous_gland0.50498775
94MP0009703_decreased_birth_body0.48176550
95MP0002970_abnormal_white_adipose0.45068991
96MP0000703_abnormal_thymus_morphology0.44738579
97MP0000681_abnormal_thyroid_gland0.44715446
98MP0000609_abnormal_liver_physiology0.44548029
99MP0003385_abnormal_body_wall0.44501202
100MP0002160_abnormal_reproductive_system0.43968026

Predicted human phenotypes

RankGene SetZ-score
1Abnormal gallbladder physiology (HP:0012438)6.79492022
2Cholecystitis (HP:0001082)6.79492022
3Aplasia/Hypoplasia of the macula (HP:0008059)5.05552708
4Reticulocytosis (HP:0001923)4.81261399
5Aplasia/Hypoplasia affecting the retina (HP:0008061)4.70463544
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.48673520
7Chromsome breakage (HP:0040012)4.36156842
8Ocular albinism (HP:0001107)4.28319286
9White forelock (HP:0002211)4.12211648
10Truncus arteriosus (HP:0001660)4.04728635
11Hypopigmentation of the fundus (HP:0007894)3.95712104
12Abnormality of reticulocytes (HP:0004312)3.92173050
13Patchy hypopigmentation of hair (HP:0011365)3.88151787
14Upper limb muscle weakness (HP:0003484)3.80665449
15Blue irides (HP:0000635)3.76770001
16Hyperthyroidism (HP:0000836)3.57158308
17Iris hypopigmentation (HP:0007730)3.57003710
18Polycythemia (HP:0001901)3.56485271
19Abnormality of the heme biosynthetic pathway (HP:0010472)3.53853520
20Increased nuchal translucency (HP:0010880)3.51977489
21Aplasia/Hypoplasia of the fovea (HP:0008060)3.50286180
22Hypoplasia of the fovea (HP:0007750)3.50286180
23Abnormal hemoglobin (HP:0011902)3.45920154
24Cholelithiasis (HP:0001081)3.41569469
25Ileus (HP:0002595)3.30608193
26Abnormality of glycolysis (HP:0004366)3.29921862
27Abnormal auditory evoked potentials (HP:0006958)3.28774261
28Ankyloglossia (HP:0010296)3.22933682
29Cutaneous melanoma (HP:0012056)3.14232941
30Abnormality of the fovea (HP:0000493)3.08342384
31Bowel incontinence (HP:0002607)3.01568895
32Abnormal gallbladder morphology (HP:0012437)2.96411716
33Birth length less than 3rd percentile (HP:0003561)2.93987621
34Orthostatic hypotension (HP:0001278)2.92116693
35Abnormal large intestine physiology (HP:0012700)2.90159534
36Hypertensive crisis (HP:0100735)2.68185613
37Abnormality of the gallbladder (HP:0005264)2.62061570
38Increased serum pyruvate (HP:0003542)2.59205024
39Nonimmune hydrops fetalis (HP:0001790)2.52653438
40Small intestinal stenosis (HP:0012848)2.51158787
41Duodenal stenosis (HP:0100867)2.51158787
42Neoplasm of head and neck (HP:0012288)2.46078573
43Esophageal neoplasm (HP:0100751)2.46078573
44Myelodysplasia (HP:0002863)2.45004816
45Morphological abnormality of the inner ear (HP:0011390)2.44461043
46Freckling (HP:0001480)2.43988764
47Atelectasis (HP:0100750)2.42917475
48Abnormality of homocysteine metabolism (HP:0010919)2.40947814
49Homocystinuria (HP:0002156)2.40947814
50Cafe-au-lait spot (HP:0000957)2.40282404
51Degeneration of anterior horn cells (HP:0002398)2.35946305
52Abnormality of the anterior horn cell (HP:0006802)2.35946305
53Generalized hypopigmentation (HP:0007513)2.34982066
54Spastic paraparesis (HP:0002313)2.34289980
55Abnormality of cochlea (HP:0000375)2.33013896
56Abnormality of oral frenula (HP:0000190)2.32699336
57Overlapping toe (HP:0001845)2.32164882
58Cortical dysplasia (HP:0002539)2.29489238
59Abnormality of the tricuspid valve (HP:0001702)2.28512491
60Seborrheic dermatitis (HP:0001051)2.22842751
61Pallor (HP:0000980)2.21500929
62Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.21402633
63Hyperbilirubinemia (HP:0002904)2.20803229
64Hypoparathyroidism (HP:0000829)2.20540165
65Abnormal lung lobation (HP:0002101)2.19735350
66Poikilocytosis (HP:0004447)2.14128828
67Hand muscle atrophy (HP:0009130)2.12143359
68Insomnia (HP:0100785)2.08073950
69Peripheral hypomyelination (HP:0007182)2.06242207
70Reticulocytopenia (HP:0001896)2.04097645
71Aplasia/Hypoplasia of the earlobes (HP:0009906)2.01093302
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.00908348
73Breech presentation (HP:0001623)2.00588401
74Abnormality of the preputium (HP:0100587)2.00138308
75Fatigue (HP:0012378)1.99950695
76Cerebral hypomyelination (HP:0006808)1.97831082
77Abnormality of chromosome stability (HP:0003220)1.96160473
78Relative macrocephaly (HP:0004482)1.95774902
79Disproportionate tall stature (HP:0001519)1.91664907
80Acute myeloid leukemia (HP:0004808)1.88775030
81Albinism (HP:0001022)1.87767019
82Nephroblastoma (Wilms tumor) (HP:0002667)1.85407078
83Abnormality of chromosome segregation (HP:0002916)1.81741649
84Metaphyseal cupping (HP:0003021)1.79888327
85Abnormality of the duodenum (HP:0002246)1.79324421
86Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77588955
87Large hands (HP:0001176)1.76590567
88Acanthocytosis (HP:0001927)1.74947028
89Delusions (HP:0000746)1.74891198
90Premature graying of hair (HP:0002216)1.74801051
91Distal upper limb amyotrophy (HP:0007149)1.74397597
92Upper limb amyotrophy (HP:0009129)1.74397597
93Embryonal renal neoplasm (HP:0011794)1.72324524
94Abnormal autonomic nervous system physiology (HP:0012332)1.71964893
95Volvulus (HP:0002580)1.70388148
96Abnormally folded helix (HP:0008544)1.69976568
97Angiofibromas (HP:0010615)1.69261017
98Adenoma sebaceum (HP:0009720)1.69261017
99Decreased motor nerve conduction velocity (HP:0003431)1.68077546
100Flat cornea (HP:0007720)1.67748635

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE15.25790230
2EIF2AK14.74808132
3PDK23.80610877
4TTK3.53332762
5KSR22.86725092
6MAP3K22.55294029
7NEK12.53483375
8PLK42.45207375
9MST1R2.29343174
10CLK12.18597037
11ICK2.17885186
12TSSK62.17393934
13AKT32.08931454
14BMPR22.00319765
15EEF2K1.97633705
16PLK21.95049435
17BUB11.91709248
18EIF2AK31.86069689
19BRAF1.79644282
20CDC71.73239165
21CCNB11.72769976
22RIPK41.72468748
23CDK121.70944992
24IRAK31.70893214
25SCYL21.68859695
26RAF11.63756709
27PLK31.63203258
28BRSK11.61881900
29KSR11.58988968
30NTRK31.53471793
31MARK31.50355125
32NEK21.47543137
33ATR1.43512187
34MET1.35762677
35BRSK21.34969536
36MAP3K81.34966857
37NME21.31247451
38CHEK21.27519284
39PLK11.23311538
40BMX1.19649766
41SRPK11.13235083
42CDK71.09947602
43CHEK11.04742883
44PTK2B1.02785971
45PBK0.95954221
46ATM0.92355873
47CDK10.80969523
48RPS6KB20.75713994
49CDK20.75485817
50NME10.73751497
51PNCK0.70167511
52PAK10.64828416
53CDK30.64094843
54AKT20.63873540
55ERN10.63617318
56AURKB0.62986614
57CDK11A0.60295616
58PRPF4B0.59279329
59MAP2K10.55660125
60CDK150.53455132
61STK30.52929285
62CDK40.52384905
63TRIB30.52350769
64CSNK2A20.52118453
65GRK60.51442686
66MTOR0.51319467
67CDK180.51089525
68MAPK100.50443240
69MAPKAPK50.48628009
70ALK0.48442947
71WNK40.47143919
72STK40.46880798
73AURKA0.43355116
74FGR0.43225528
75CSNK2A10.43002802
76TRPM70.42143014
77TAOK20.41535387
78CDK140.41381848
79RET0.41047064
80ERBB40.40870434
81EIF2AK20.40219115
82RPS6KA40.38655058
83CSNK1E0.37417733
84MAP3K10.36501263
85LRRK20.36129782
86NEK60.32404637
87MAPKAPK30.31841280
88PRKDC0.31698420
89LATS20.31092551
90JAK20.30842117
91PAK40.30814296
92MAPK110.30452715
93STK100.29962473
94GSK3B0.28790188
95IRAK20.28375317
96MAPK140.27421406
97AKT10.26235741
98PAK20.21237767
99PTK60.20921695
100WNK10.20533402

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.91898871
2Mismatch repair_Homo sapiens_hsa034303.62214722
3Homologous recombination_Homo sapiens_hsa034403.53180740
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.48837319
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.93995230
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.65643155
7Cell cycle_Homo sapiens_hsa041102.62681690
8One carbon pool by folate_Homo sapiens_hsa006702.54415308
9RNA transport_Homo sapiens_hsa030132.48707475
10Non-homologous end-joining_Homo sapiens_hsa034502.35348877
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18939655
12Nucleotide excision repair_Homo sapiens_hsa034202.18578699
13Pyruvate metabolism_Homo sapiens_hsa006202.06203484
14Spliceosome_Homo sapiens_hsa030401.96422530
15Biosynthesis of amino acids_Homo sapiens_hsa012301.94987260
16Carbon metabolism_Homo sapiens_hsa012001.90154508
17Base excision repair_Homo sapiens_hsa034101.90148005
18Proteasome_Homo sapiens_hsa030501.90146879
19Pentose phosphate pathway_Homo sapiens_hsa000301.86647246
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.80197544
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.77824207
22Fanconi anemia pathway_Homo sapiens_hsa034601.72330164
23mRNA surveillance pathway_Homo sapiens_hsa030151.72114575
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.71926905
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.65072914
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.57555520
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.57057460
28Oocyte meiosis_Homo sapiens_hsa041141.51190228
29Fructose and mannose metabolism_Homo sapiens_hsa000511.34672113
30Protein export_Homo sapiens_hsa030601.31662892
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.20556420
32Ribosome_Homo sapiens_hsa030101.20069293
33Fatty acid elongation_Homo sapiens_hsa000621.19610565
34Tyrosine metabolism_Homo sapiens_hsa003501.18978082
35Basal transcription factors_Homo sapiens_hsa030221.17315192
36Sulfur relay system_Homo sapiens_hsa041221.13423101
37N-Glycan biosynthesis_Homo sapiens_hsa005101.13104829
38Parkinsons disease_Homo sapiens_hsa050121.12322293
39Thyroid cancer_Homo sapiens_hsa052161.05644403
40Propanoate metabolism_Homo sapiens_hsa006401.04360764
41Pyrimidine metabolism_Homo sapiens_hsa002401.03846229
42Acute myeloid leukemia_Homo sapiens_hsa052210.98358354
43Other glycan degradation_Homo sapiens_hsa005110.96309403
44Chronic myeloid leukemia_Homo sapiens_hsa052200.96249935
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94214178
46RNA degradation_Homo sapiens_hsa030180.91170626
47Central carbon metabolism in cancer_Homo sapiens_hsa052300.90574677
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88312609
49Non-small cell lung cancer_Homo sapiens_hsa052230.86776657
50Steroid biosynthesis_Homo sapiens_hsa001000.81307434
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80732494
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78238579
53Pancreatic cancer_Homo sapiens_hsa052120.77115881
54mTOR signaling pathway_Homo sapiens_hsa041500.73447539
55Huntingtons disease_Homo sapiens_hsa050160.73413072
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73392592
57RNA polymerase_Homo sapiens_hsa030200.70384065
58Oxidative phosphorylation_Homo sapiens_hsa001900.70186268
59Prion diseases_Homo sapiens_hsa050200.69526479
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69352663
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.66785537
62Fatty acid metabolism_Homo sapiens_hsa012120.66746463
63Prostate cancer_Homo sapiens_hsa052150.64957071
64Bladder cancer_Homo sapiens_hsa052190.63562899
65Purine metabolism_Homo sapiens_hsa002300.62736206
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59155085
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.57436881
68Glutathione metabolism_Homo sapiens_hsa004800.55944007
69Lysine degradation_Homo sapiens_hsa003100.55934612
70Arginine biosynthesis_Homo sapiens_hsa002200.51760251
71Small cell lung cancer_Homo sapiens_hsa052220.51377604
72p53 signaling pathway_Homo sapiens_hsa041150.50244157
73Galactose metabolism_Homo sapiens_hsa000520.50085371
74Vitamin B6 metabolism_Homo sapiens_hsa007500.46218234
75Epstein-Barr virus infection_Homo sapiens_hsa051690.44208341
76Insulin signaling pathway_Homo sapiens_hsa049100.44163153
77Metabolic pathways_Homo sapiens_hsa011000.42182344
78HIF-1 signaling pathway_Homo sapiens_hsa040660.41566249
79Viral carcinogenesis_Homo sapiens_hsa052030.40817951
80Glioma_Homo sapiens_hsa052140.39261361
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38939907
82VEGF signaling pathway_Homo sapiens_hsa043700.35602890
83ErbB signaling pathway_Homo sapiens_hsa040120.35073616
84Alzheimers disease_Homo sapiens_hsa050100.35058362
85Type II diabetes mellitus_Homo sapiens_hsa049300.34310474
86Renal cell carcinoma_Homo sapiens_hsa052110.33643118
87Inositol phosphate metabolism_Homo sapiens_hsa005620.31856598
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31448797
89Vibrio cholerae infection_Homo sapiens_hsa051100.31146609
90MicroRNAs in cancer_Homo sapiens_hsa052060.29382803
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28760950
92Hepatitis B_Homo sapiens_hsa051610.27936974
93Olfactory transduction_Homo sapiens_hsa047400.26436129
94Melanoma_Homo sapiens_hsa052180.24196553
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23729936
96Colorectal cancer_Homo sapiens_hsa052100.23704775
97Endometrial cancer_Homo sapiens_hsa052130.17777394
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.17584352
99Selenocompound metabolism_Homo sapiens_hsa004500.15559626
100Arginine and proline metabolism_Homo sapiens_hsa003300.15258523

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