MAGEC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the other MAGEC genes are clustered on chromosome Xq26-q27. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gas transport (GO:0015669)6.04231070
2oxygen transport (GO:0015671)5.87890472
3nuclear pore complex assembly (GO:0051292)5.51520226
4regulation of translational fidelity (GO:0006450)5.45394462
5protoporphyrinogen IX metabolic process (GO:0046501)4.89235163
6proline biosynthetic process (GO:0006561)4.86508219
7COPI coating of Golgi vesicle (GO:0048205)4.82191396
8Golgi transport vesicle coating (GO:0048200)4.82191396
9nuclear pore organization (GO:0006999)4.79687170
10ribosome assembly (GO:0042255)4.63664967
11protoporphyrinogen IX biosynthetic process (GO:0006782)4.51294861
12formation of translation preinitiation complex (GO:0001731)4.47376274
13DNA replication initiation (GO:0006270)4.44308069
14DNA replication checkpoint (GO:0000076)4.33207683
15mitotic sister chromatid segregation (GO:0000070)4.29040870
16DNA topological change (GO:0006265)4.27357334
17homocysteine metabolic process (GO:0050667)4.21433109
18mitotic nuclear envelope disassembly (GO:0007077)4.19082436
19DNA unwinding involved in DNA replication (GO:0006268)4.16151386
20mitotic chromosome condensation (GO:0007076)4.15167644
21pore complex assembly (GO:0046931)4.11191940
22regulation of mitotic spindle organization (GO:0060236)4.10091884
23DNA strand elongation involved in DNA replication (GO:0006271)4.05635324
24proteasome assembly (GO:0043248)4.00736300
25tRNA aminoacylation for protein translation (GO:0006418)4.00640796
26sister chromatid segregation (GO:0000819)3.98458145
27DNA strand elongation (GO:0022616)3.93260609
28amino acid activation (GO:0043038)3.86641449
29tRNA aminoacylation (GO:0043039)3.86641449
30telomere maintenance via semi-conservative replication (GO:0032201)3.84719143
31nuclear envelope disassembly (GO:0051081)3.82256945
32membrane disassembly (GO:0030397)3.82256945
33regulation of histone H3-K27 methylation (GO:0061085)3.70469290
34synapsis (GO:0007129)3.63333227
35regulation of RNA export from nucleus (GO:0046831)3.57970290
36resolution of meiotic recombination intermediates (GO:0000712)3.56310973
37rRNA methylation (GO:0031167)3.54217453
38ribosome biogenesis (GO:0042254)3.51658275
39regulation of histone H3-K4 methylation (GO:0051569)3.51400582
40rRNA modification (GO:0000154)3.50393849
41ribosomal small subunit assembly (GO:0000028)3.48913386
42diterpenoid biosynthetic process (GO:0016102)3.41327388
43tetrahydrofolate metabolic process (GO:0046653)3.40721750
44regulation of translational elongation (GO:0006448)3.40129395
45oxidative phosphorylation (GO:0006119)3.36145697
46terpenoid biosynthetic process (GO:0016114)3.33640383
47nucleobase-containing small molecule interconversion (GO:0015949)3.31086716
48ribosomal large subunit biogenesis (GO:0042273)3.26308715
49ribonucleoprotein complex biogenesis (GO:0022613)3.25740970
50erythrocyte development (GO:0048821)3.25020195
51mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.24274223
52telomere maintenance via recombination (GO:0000722)3.22031160
53heme biosynthetic process (GO:0006783)3.21135922
54ATP synthesis coupled proton transport (GO:0015986)3.18781966
55energy coupled proton transport, down electrochemical gradient (GO:0015985)3.18781966
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.16275099
57mitotic metaphase plate congression (GO:0007080)3.10456928
58folic acid metabolic process (GO:0046655)3.10226864
59oxaloacetate metabolic process (GO:0006107)3.10130496
60purine nucleobase biosynthetic process (GO:0009113)3.09967374
61maturation of SSU-rRNA (GO:0030490)3.09076471
62mitotic recombination (GO:0006312)3.07400390
63chromosome segregation (GO:0007059)3.06035478
64proline metabolic process (GO:0006560)3.05310330
65IMP biosynthetic process (GO:0006188)3.05188916
66regulation of nucleobase-containing compound transport (GO:0032239)3.00174186
67aspartate family amino acid biosynthetic process (GO:0009067)2.99300076
68regulation of spindle organization (GO:0090224)2.98233083
69S-adenosylmethionine metabolic process (GO:0046500)2.96639548
70nuclear envelope organization (GO:0006998)2.96060006
71meiotic chromosome segregation (GO:0045132)2.92957294
72porphyrin-containing compound biosynthetic process (GO:0006779)2.92440724
73folic acid-containing compound biosynthetic process (GO:0009396)2.84948599
74regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.84601024
75erythrocyte maturation (GO:0043249)2.82723819
76chromosome condensation (GO:0030261)2.81754857
77ribosomal small subunit biogenesis (GO:0042274)2.80645725
78heme metabolic process (GO:0042168)2.80021114
79DNA synthesis involved in DNA repair (GO:0000731)2.79857826
80* positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.79667445
81anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.78707561
82protein localization to kinetochore (GO:0034501)2.77941145
83negative regulation of protein acetylation (GO:1901984)2.77846317
84tricarboxylic acid cycle (GO:0006099)2.77651199
85negative regulation of fatty acid biosynthetic process (GO:0045717)2.77631196
86nucleobase biosynthetic process (GO:0046112)2.76567330
87maturation of 5.8S rRNA (GO:0000460)2.76087327
88DNA packaging (GO:0006323)2.75230502
89protein export from nucleus (GO:0006611)2.74439945
90negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.73566067
91telomere maintenance via telomere lengthening (GO:0010833)2.72747314
92translational initiation (GO:0006413)2.72652590
93one-carbon compound transport (GO:0019755)2.71537948
94regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.70981986
95porphyrin-containing compound metabolic process (GO:0006778)2.69102389
96* positive regulation of ligase activity (GO:0051351)2.67802055
97purine nucleoside monophosphate biosynthetic process (GO:0009127)2.67217908
98purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.67217908
99metaphase plate congression (GO:0051310)2.65170104
100response to thyroid hormone (GO:0097066)2.64943441

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.16244438
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.68931286
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35656968
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.31649203
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.22157570
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.15452183
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.85373482
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83414158
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.74558852
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.60144829
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.59620807
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.57168752
13XRN2_22483619_ChIP-Seq_HELA_Human2.46092182
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.46000797
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39082990
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38408716
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.37176729
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.33963406
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28108379
20NCOR1_26117541_ChIP-Seq_K562_Human2.21559938
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16866080
22ZNF263_19887448_ChIP-Seq_K562_Human2.15414153
23DCP1A_22483619_ChIP-Seq_HELA_Human2.13251288
24THAP11_20581084_ChIP-Seq_MESCs_Mouse2.03498271
25NELFA_20434984_ChIP-Seq_ESCs_Mouse1.99055367
26AR_21909140_ChIP-Seq_LNCAP_Human1.96823780
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.93710039
28TTF2_22483619_ChIP-Seq_HELA_Human1.90588841
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.85101448
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.81247037
31GABP_19822575_ChIP-Seq_HepG2_Human1.80665241
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79569932
33PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.76327028
34KDM5A_27292631_Chip-Seq_BREAST_Human1.73551710
35GATA1_19941826_ChIP-Seq_K562_Human1.73343061
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.69321600
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.67972385
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65996074
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65510667
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60318078
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.57907662
42ELK1_19687146_ChIP-ChIP_HELA_Human1.57506787
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56711032
44FOXP3_21729870_ChIP-Seq_TREG_Human1.56691315
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54932651
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54918826
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.50910381
48VDR_23849224_ChIP-Seq_CD4+_Human1.43673685
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.42356652
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39593059
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38229371
52BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37910427
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36891933
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36567122
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36484231
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35247646
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35083235
58GATA1_22025678_ChIP-Seq_K562_Human1.34831455
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.33876255
60TFEB_21752829_ChIP-Seq_HELA_Human1.28578914
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26425233
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26087833
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25192958
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24818178
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22746619
66CIITA_25753668_ChIP-Seq_RAJI_Human1.22243545
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21328118
68GATA2_19941826_ChIP-Seq_K562_Human1.21195439
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19836278
70CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17393481
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16936209
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16716151
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15980840
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15434904
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15187778
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14118367
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13852736
78CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11658736
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08812459
80MYC_22102868_ChIP-Seq_BL_Human1.07295587
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06922350
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06503932
83TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04646096
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00020146
85ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99513811
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98407808
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96199350
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95862820
89CHD1_26751641_Chip-Seq_LNCaP_Human0.94581438
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94120197
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91446816
92ELK3_25401928_ChIP-Seq_HUVEC_Human0.90013089
93GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88608495
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88566734
95SPI1_23127762_ChIP-Seq_K562_Human0.88362643
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88265289
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86396188
98RACK7_27058665_Chip-Seq_MCF-7_Human0.84102859
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81955210
100NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80543142

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level5.04113190
2MP0003111_abnormal_nucleus_morphology3.82780411
3MP0005171_absent_coat_pigmentation3.59617310
4MP0004957_abnormal_blastocyst_morpholog3.50996696
5MP0008058_abnormal_DNA_repair3.32487221
6MP0010094_abnormal_chromosome_stability3.29260764
7MP0003693_abnormal_embryo_hatching3.08695516
8MP0000372_irregular_coat_pigmentation3.07501459
9MP0000678_abnormal_parathyroid_gland2.74683971
10MP0008995_early_reproductive_senescence2.74482670
11MP0003656_abnormal_erythrocyte_physiolo2.67286330
12MP0008932_abnormal_embryonic_tissue2.67091504
13MP0003786_premature_aging2.53522684
14MP0005083_abnormal_biliary_tract2.53150540
15MP0003077_abnormal_cell_cycle2.47597187
16MP0009697_abnormal_copulation2.47102045
17MP0005451_abnormal_body_composition2.46537383
18MP0002132_abnormal_respiratory_system2.35988410
19MP0008007_abnormal_cellular_replicative2.34570204
20MP0004233_abnormal_muscle_weight2.25404113
21MP0005408_hypopigmentation2.23974400
22MP0008057_abnormal_DNA_replication2.22943642
23MP0003806_abnormal_nucleotide_metabolis2.08771960
24MP0001545_abnormal_hematopoietic_system2.04587860
25MP0005397_hematopoietic_system_phenotyp2.04587860
26MP0003718_maternal_effect1.77472147
27MP0006036_abnormal_mitochondrial_physio1.76655510
28MP0001661_extended_life_span1.74515666
29MP0006035_abnormal_mitochondrial_morpho1.69185061
30MP0008438_abnormal_cutaneous_collagen1.68627982
31MP0005058_abnormal_lysosome_morphology1.63927143
32MP0000350_abnormal_cell_proliferation1.60452760
33MP0001730_embryonic_growth_arrest1.57092345
34MP0001697_abnormal_embryo_size1.50256357
35MP0003186_abnormal_redox_activity1.46655993
36MP0002080_prenatal_lethality1.43506347
37MP0002877_abnormal_melanocyte_morpholog1.39840733
38MP0003950_abnormal_plasma_membrane1.38548317
39MP0000313_abnormal_cell_death1.38029793
40MP0001672_abnormal_embryogenesis/_devel1.36419511
41MP0005380_embryogenesis_phenotype1.36419511
42MP0000015_abnormal_ear_pigmentation1.34391704
43MP0000358_abnormal_cell_content/1.32737535
44MP0003984_embryonic_growth_retardation1.30580663
45MP0003959_abnormal_lean_body1.29107625
46MP0001881_abnormal_mammary_gland1.28846471
47MP0002095_abnormal_skin_pigmentation1.28366742
48MP0004264_abnormal_extraembryonic_tissu1.28119393
49MP0002210_abnormal_sex_determination1.28047369
50MP0002088_abnormal_embryonic_growth/wei1.25736441
51MP0001764_abnormal_homeostasis1.21542546
52MP0004145_abnormal_muscle_electrophysio1.21350858
53MP0002269_muscular_atrophy1.17141517
54MP0002086_abnormal_extraembryonic_tissu1.15844311
55MP0001929_abnormal_gametogenesis1.15425319
56MP0010234_abnormal_vibrissa_follicle1.11546231
57MP0005636_abnormal_mineral_homeostasis1.10551993
58MP0003136_yellow_coat_color1.03213802
59MP0010307_abnormal_tumor_latency1.03105158
60MP0004272_abnormal_basement_membrane1.00408712
61MP0002938_white_spotting0.97226311
62MP0009278_abnormal_bone_marrow0.96693012
63MP0000681_abnormal_thyroid_gland0.96640563
64MP0004808_abnormal_hematopoietic_stem0.95248573
65MP0008770_decreased_survivor_rate0.94609653
66MP0002075_abnormal_coat/hair_pigmentati0.93347087
67MP0004381_abnormal_hair_follicle0.90108472
68MP0005410_abnormal_fertilization0.89046404
69MP0001727_abnormal_embryo_implantation0.87432197
70MP0000371_diluted_coat_color0.86688194
71MP0000647_abnormal_sebaceous_gland0.86299425
72MP0001186_pigmentation_phenotype0.82992224
73MP0001145_abnormal_male_reproductive0.81528027
74MP0001502_abnormal_circadian_rhythm0.80746791
75MP0003698_abnormal_male_reproductive0.79872073
76MP0002019_abnormal_tumor_incidence0.79846884
77MP0002396_abnormal_hematopoietic_system0.79833619
78MP0002084_abnormal_developmental_patter0.79501878
79MP0003221_abnormal_cardiomyocyte_apopto0.79175465
80MP0005501_abnormal_skin_physiology0.78717555
81MP0009840_abnormal_foam_cell0.78338190
82MP0002085_abnormal_embryonic_tissue0.78058984
83MP0000609_abnormal_liver_physiology0.77726654
84MP0008775_abnormal_heart_ventricle0.77386970
85MP0005330_cardiomyopathy0.76304771
86MP0009931_abnormal_skin_appearance0.73728985
87MP0000749_muscle_degeneration0.72169755
88MP0000653_abnormal_sex_gland0.72003333
89MP0000747_muscle_weakness0.71099930
90MP0003699_abnormal_female_reproductive0.69324229
91MP0002161_abnormal_fertility/fecundity0.67817646
92MP0009333_abnormal_splenocyte_physiolog0.66395471
93MP0000598_abnormal_liver_morphology0.64018407
94MP0009672_abnormal_birth_weight0.62095728
95MP0000377_abnormal_hair_follicle0.61563024
96MP0005384_cellular_phenotype0.61432153
97MP0002160_abnormal_reproductive_system0.61395574
98MP0000703_abnormal_thymus_morphology0.61214194
99MP0005075_abnormal_melanosome_morpholog0.60293139
100MP0005332_abnormal_amino_acid0.57132287

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)6.55666648
2Abnormal gallbladder physiology (HP:0012438)6.55666648
3Abnormality of the heme biosynthetic pathway (HP:0010472)5.95317860
4Reticulocytosis (HP:0001923)5.60338048
5Abnormal hemoglobin (HP:0011902)5.24692277
6Truncus arteriosus (HP:0001660)5.23681972
7Hyperthyroidism (HP:0000836)4.95312445
8Abnormality of reticulocytes (HP:0004312)4.42058264
9Polycythemia (HP:0001901)4.25251124
10Hypertensive crisis (HP:0100735)4.10003209
11Ileus (HP:0002595)3.76770422
12Upper limb muscle weakness (HP:0003484)3.62383979
13Abnormality of glycolysis (HP:0004366)3.61002538
14Homocystinuria (HP:0002156)3.57200529
15Abnormality of homocysteine metabolism (HP:0010919)3.57200529
16Ankyloglossia (HP:0010296)3.51726323
17Bowel incontinence (HP:0002607)3.41597735
18Seborrheic dermatitis (HP:0001051)3.40377462
19Abnormal large intestine physiology (HP:0012700)3.37187101
20Cholelithiasis (HP:0001081)3.37028721
21Pallor (HP:0000980)3.25543187
22Increased serum pyruvate (HP:0003542)3.24113022
23Hypoparathyroidism (HP:0000829)3.18979578
24Acute encephalopathy (HP:0006846)3.01360267
25Poikilocytosis (HP:0004447)2.98422141
26Abnormality of the tricuspid valve (HP:0001702)2.97512637
27Abnormal gallbladder morphology (HP:0012437)2.96136564
28Tinnitus (HP:0000360)2.86840939
29Cerebral hypomyelination (HP:0006808)2.82716981
30Short middle phalanx of the 5th finger (HP:0004220)2.79155347
31Acute necrotizing encephalopathy (HP:0006965)2.77322026
32Cortical dysplasia (HP:0002539)2.76384585
33Abnormal mitochondria in muscle tissue (HP:0008316)2.73430386
34Spastic paraparesis (HP:0002313)2.72327648
35Birth length less than 3rd percentile (HP:0003561)2.69944396
36Nonimmune hydrops fetalis (HP:0001790)2.69065772
37Acanthocytosis (HP:0001927)2.68926247
38Atelectasis (HP:0100750)2.65843527
39Abnormality of oral frenula (HP:0000190)2.59143915
40Abnormality of the gallbladder (HP:0005264)2.54748521
41Insomnia (HP:0100785)2.51897794
42Hypokinesia (HP:0002375)2.51858438
43Hyperbilirubinemia (HP:0002904)2.42151088
44Abnormal platelet function (HP:0011869)2.41098585
45Impaired platelet aggregation (HP:0003540)2.41098585
46Chromosomal breakage induced by crosslinking agents (HP:0003221)2.38447235
47Aplasia/Hypoplasia of the earlobes (HP:0009906)2.38421418
48Patellar dislocation (HP:0002999)2.35573506
49Abnormality of sulfur amino acid metabolism (HP:0004339)2.34724303
50Entropion (HP:0000621)2.31957155
51Chromsome breakage (HP:0040012)2.31528583
52Orthostatic hypotension (HP:0001278)2.30070983
53Myopathic facies (HP:0002058)2.29354974
54Abnormally folded helix (HP:0008544)2.26986684
55Abnormality of cells of the erythroid lineage (HP:0012130)2.25572894
56Breech presentation (HP:0001623)2.23752721
57Abnormal number of erythroid precursors (HP:0012131)2.20676026
58Morphological abnormality of the inner ear (HP:0011390)2.19750604
59Progressive macrocephaly (HP:0004481)2.18927108
60Premature ovarian failure (HP:0008209)2.13393720
61Increased connective tissue (HP:0009025)2.11443591
62Aplasia/Hypoplasia of the thymus (HP:0010515)2.00776663
63Diaphragmatic weakness (HP:0009113)2.00621029
64Secondary amenorrhea (HP:0000869)2.00298883
65Increased nuchal translucency (HP:0010880)1.98972579
66Hand muscle atrophy (HP:0009130)1.96229237
67Degeneration of anterior horn cells (HP:0002398)1.94513815
68Abnormality of the anterior horn cell (HP:0006802)1.94513815
69Abnormality of cochlea (HP:0000375)1.94168302
70Neoplasm of head and neck (HP:0012288)1.93379016
71Esophageal neoplasm (HP:0100751)1.93379016
72Type I transferrin isoform profile (HP:0003642)1.92788443
73Congenital ichthyosiform erythroderma (HP:0007431)1.92574367
74Reticulocytopenia (HP:0001896)1.92356500
75Fatigue (HP:0012378)1.91749664
76Peripheral hypomyelination (HP:0007182)1.90718638
77Overfolded helix (HP:0000396)1.90495216
78Redundant skin (HP:0001582)1.85225708
79Overlapping toe (HP:0001845)1.84275148
80CNS hypomyelination (HP:0003429)1.80611290
81Myelodysplasia (HP:0002863)1.79651404
82Increased CSF lactate (HP:0002490)1.79232142
83Macrocytic anemia (HP:0001972)1.76579364
84Flat cornea (HP:0007720)1.69414204
85Cerebral edema (HP:0002181)1.67588555
86Epiphyseal stippling (HP:0010655)1.66681118
87Acute myeloid leukemia (HP:0004808)1.66659034
88Hepatocellular carcinoma (HP:0001402)1.63952894
89Sandal gap (HP:0001852)1.63318954
90Cheekbone underdevelopment (HP:0010669)1.61809194
91Abnormal autonomic nervous system physiology (HP:0012332)1.61490807
92Small intestinal stenosis (HP:0012848)1.60715243
93Duodenal stenosis (HP:0100867)1.60715243
94Venous abnormality (HP:0002624)1.59990970
95Palpitations (HP:0001962)1.59986843
96Paraparesis (HP:0002385)1.59652452
97Gastrointestinal dysmotility (HP:0002579)1.58673614
98Exercise intolerance (HP:0003546)1.58210989
99Mitochondrial inheritance (HP:0001427)1.57439999
100Venous insufficiency (HP:0005293)1.57375216

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.67955157
2CLK13.87782002
3TTK3.24647457
4RIPK42.82837167
5BUB12.82606181
6TSSK62.70366767
7NEK12.70216217
8KSR22.61431038
9NME22.58643413
10WEE12.56342234
11BMPR22.38879487
12IRAK32.35870722
13PLK42.29275204
14CDC72.12023717
15SRPK12.08161438
16PDK21.98027311
17CCNB11.88514414
18PBK1.85859488
19MAP3K21.75020500
20RAF11.68014220
21EEF2K1.65348923
22BMX1.56030741
23BRSK11.51811017
24ERN11.51246004
25BRSK21.46963928
26NME11.46845806
27ICK1.44617314
28EPHA21.44597746
29MAP3K81.43686324
30TRIB31.42061222
31CDK121.42059534
32EIF2AK31.36232863
33KSR11.35221308
34LMTK21.34814264
35RPS6KB21.34391336
36NTRK31.31392622
37SCYL21.30162761
38MAPKAPK31.25997932
39CHEK21.21878651
40TESK21.14828215
41MST41.05642495
42TRPM70.99252806
43ATR0.98338694
44NEK20.98196305
45STK40.97156650
46PKN20.96471232
47PLK30.95721263
48CHEK10.91440566
49PAK10.90045326
50ILK0.85969629
51AKT30.85656731
52GRK70.85496087
53ERBB40.81025678
54LRRK20.80171008
55BRAF0.80147040
56PTK60.79385598
57PAK40.79371561
58MST1R0.76125511
59AURKB0.75867107
60ALK0.75419866
61TAOK20.72734235
62PLK10.71271538
63ATM0.64978865
64STK30.64710254
65CDK10.63329758
66CDK70.59911435
67CSNK2A20.59869190
68CDK20.56202960
69RET0.54182645
70STK100.53225355
71TAOK30.53211443
72RPS6KA50.51448884
73MTOR0.50446135
74MAP2K10.50245109
75MET0.47305133
76MARK30.44850995
77NTRK10.42882568
78JAK20.42505861
79CSNK2A10.41366731
80AURKA0.41211547
81PRPF4B0.40073620
82CSNK1E0.37930013
83CDK11A0.36961326
84CDK150.35305498
85PAK20.34917224
86PLK20.34748514
87LATS20.34676589
88CDK180.34284450
89DMPK0.33407287
90DYRK30.33074793
91CDK80.32643612
92PHKG20.32596281
93PHKG10.32596281
94CDK140.30644060
95MAP3K10.30109043
96YES10.28735923
97WNK40.27806315
98PTK20.27527931
99PRKDC0.26255931
100EIF2AK20.24961508

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009704.20350715
2DNA replication_Homo sapiens_hsa030303.56367815
3One carbon pool by folate_Homo sapiens_hsa006703.12158197
4Mismatch repair_Homo sapiens_hsa034303.07765957
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.94086838
6Proteasome_Homo sapiens_hsa030502.78171151
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.59510052
8Ribosome_Homo sapiens_hsa030102.48817261
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.38563901
10Homologous recombination_Homo sapiens_hsa034402.29932851
11RNA transport_Homo sapiens_hsa030132.22805873
12Biosynthesis of amino acids_Homo sapiens_hsa012302.17332246
13Steroid biosynthesis_Homo sapiens_hsa001002.17007581
14Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.08298599
15Carbon metabolism_Homo sapiens_hsa012002.04220468
16Nucleotide excision repair_Homo sapiens_hsa034202.01665443
17Spliceosome_Homo sapiens_hsa030401.98863120
18Base excision repair_Homo sapiens_hsa034101.87746516
19Cell cycle_Homo sapiens_hsa041101.87664095
20Oxidative phosphorylation_Homo sapiens_hsa001901.77501990
21Pentose phosphate pathway_Homo sapiens_hsa000301.75351095
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73746561
23RNA polymerase_Homo sapiens_hsa030201.73482632
24Other glycan degradation_Homo sapiens_hsa005111.70966678
25Pyruvate metabolism_Homo sapiens_hsa006201.70905534
26Parkinsons disease_Homo sapiens_hsa050121.67224328
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59777187
28Fanconi anemia pathway_Homo sapiens_hsa034601.59457102
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.58160044
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.49432946
31N-Glycan biosynthesis_Homo sapiens_hsa005101.46957312
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.43795562
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.43256865
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.42550806
35Pyrimidine metabolism_Homo sapiens_hsa002401.36055540
36Huntingtons disease_Homo sapiens_hsa050161.32230002
37Fructose and mannose metabolism_Homo sapiens_hsa000511.27079524
38Tyrosine metabolism_Homo sapiens_hsa003501.23834666
39Fatty acid elongation_Homo sapiens_hsa000621.20462997
40Basal transcription factors_Homo sapiens_hsa030221.19519796
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16832279
42Selenocompound metabolism_Homo sapiens_hsa004501.14502812
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11755986
44mRNA surveillance pathway_Homo sapiens_hsa030151.10489183
45Protein export_Homo sapiens_hsa030601.00114448
46RNA degradation_Homo sapiens_hsa030180.94475673
47Sulfur relay system_Homo sapiens_hsa041220.93057953
48Alzheimers disease_Homo sapiens_hsa050100.91753061
49Non-homologous end-joining_Homo sapiens_hsa034500.90758181
50Purine metabolism_Homo sapiens_hsa002300.90503322
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.87700843
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85420228
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82436949
54Thyroid cancer_Homo sapiens_hsa052160.71824916
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71556052
56Glutathione metabolism_Homo sapiens_hsa004800.71495166
57Acute myeloid leukemia_Homo sapiens_hsa052210.67670116
58Propanoate metabolism_Homo sapiens_hsa006400.67326636
59Metabolic pathways_Homo sapiens_hsa011000.65644550
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.65109314
61HIF-1 signaling pathway_Homo sapiens_hsa040660.63728186
62Chronic myeloid leukemia_Homo sapiens_hsa052200.63528353
63Galactose metabolism_Homo sapiens_hsa000520.63277358
64Fatty acid metabolism_Homo sapiens_hsa012120.61902304
65Oocyte meiosis_Homo sapiens_hsa041140.61161121
66Prion diseases_Homo sapiens_hsa050200.56628094
67p53 signaling pathway_Homo sapiens_hsa041150.53204915
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52793047
69Arginine and proline metabolism_Homo sapiens_hsa003300.51215133
70Vibrio cholerae infection_Homo sapiens_hsa051100.50750288
71mTOR signaling pathway_Homo sapiens_hsa041500.50626147
72Phenylalanine metabolism_Homo sapiens_hsa003600.46462593
73Epstein-Barr virus infection_Homo sapiens_hsa051690.45344000
74Arginine biosynthesis_Homo sapiens_hsa002200.45284985
75Viral carcinogenesis_Homo sapiens_hsa052030.45234917
76Non-small cell lung cancer_Homo sapiens_hsa052230.44799532
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43983080
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40116363
79Lysine degradation_Homo sapiens_hsa003100.36196116
80ErbB signaling pathway_Homo sapiens_hsa040120.33761682
81Renal cell carcinoma_Homo sapiens_hsa052110.33710335
82Insulin signaling pathway_Homo sapiens_hsa049100.33323878
83Vitamin B6 metabolism_Homo sapiens_hsa007500.32719857
84Sulfur metabolism_Homo sapiens_hsa009200.31839691
85Pancreatic cancer_Homo sapiens_hsa052120.26782881
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26509280
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26346709
88Bladder cancer_Homo sapiens_hsa052190.26332919
89Butanoate metabolism_Homo sapiens_hsa006500.26220831
90Cardiac muscle contraction_Homo sapiens_hsa042600.24980208
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.24903345
92Shigellosis_Homo sapiens_hsa051310.24310042
93MicroRNAs in cancer_Homo sapiens_hsa052060.22713707
94Olfactory transduction_Homo sapiens_hsa047400.22564255
95Apoptosis_Homo sapiens_hsa042100.22305123
96VEGF signaling pathway_Homo sapiens_hsa043700.19641683
97Lysosome_Homo sapiens_hsa041420.13608490
98Folate biosynthesis_Homo sapiens_hsa007900.11647973
99Type II diabetes mellitus_Homo sapiens_hsa049300.11244722
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.10500622

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