MAGED1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homology with members of the MAGE family, it is expressed in almost all normal adult tissues. This gene has been demonstrated to be involved in the p75 neurotrophin receptor mediated programmed cell death pathway. Three transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)4.87504873
2COPI coating of Golgi vesicle (GO:0048205)4.78982557
3Golgi transport vesicle coating (GO:0048200)4.78982557
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.46324023
5nucleobase catabolic process (GO:0046113)4.23829747
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.18529319
7presynaptic membrane assembly (GO:0097105)3.96943301
8layer formation in cerebral cortex (GO:0021819)3.76838133
9synaptic vesicle maturation (GO:0016188)3.64966531
10regulation of synaptic vesicle exocytosis (GO:2000300)3.62778147
11synaptic vesicle exocytosis (GO:0016079)3.53612814
12cerebellar Purkinje cell layer development (GO:0021680)3.52361376
13presynaptic membrane organization (GO:0097090)3.50961947
14calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.40205486
15synaptic vesicle docking involved in exocytosis (GO:0016081)3.39574060
16axonal fasciculation (GO:0007413)3.36207643
17innervation (GO:0060384)3.28540208
18locomotory exploration behavior (GO:0035641)3.27734589
19vocalization behavior (GO:0071625)3.27321946
20neuron cell-cell adhesion (GO:0007158)3.26057589
21neuron recognition (GO:0008038)3.20531708
22positive regulation of mitochondrial fission (GO:0090141)3.18121169
23establishment of mitochondrion localization (GO:0051654)3.15351558
24axon extension involved in axon guidance (GO:0048846)3.15326893
25neuron projection extension involved in neuron projection guidance (GO:1902284)3.15326893
26retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.15006711
27gonadal mesoderm development (GO:0007506)3.07382480
28regulation of synaptic vesicle transport (GO:1902803)3.05781925
29retinal ganglion cell axon guidance (GO:0031290)3.04500474
30activation of protein kinase A activity (GO:0034199)3.03155865
31neurotransmitter-gated ion channel clustering (GO:0072578)3.03070322
32regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.01591968
33regulation of glutamate receptor signaling pathway (GO:1900449)2.99252986
34pyrimidine nucleobase catabolic process (GO:0006208)2.99061326
35neurotransmitter secretion (GO:0007269)2.98937302
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.98819231
37glutamate secretion (GO:0014047)2.93823142
38nonmotile primary cilium assembly (GO:0035058)2.92290067
39cell communication by electrical coupling (GO:0010644)2.91650827
40dendrite morphogenesis (GO:0048813)2.90319554
41protein localization to synapse (GO:0035418)2.90271187
42dendritic spine morphogenesis (GO:0060997)2.90156620
43positive regulation of synaptic transmission, GABAergic (GO:0032230)2.88008161
44maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.87308571
45membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.86939092
46vesicle coating (GO:0006901)2.86642848
47negative regulation of axon guidance (GO:1902668)2.85575286
48cell migration in hindbrain (GO:0021535)2.85009386
49gamma-aminobutyric acid transport (GO:0015812)2.81511666
50regulation of synapse structural plasticity (GO:0051823)2.81385693
51detection of calcium ion (GO:0005513)2.78824968
52exploration behavior (GO:0035640)2.78135816
53insulin secretion (GO:0030073)2.75658424
54cholesterol biosynthetic process (GO:0006695)2.74587612
55regulation of neuronal synaptic plasticity (GO:0048168)2.73210918
56negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.72610835
57positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.71042799
58negative regulation of synaptic transmission, GABAergic (GO:0032229)2.69261085
59negative regulation of oligodendrocyte differentiation (GO:0048715)2.68837130
60sequestering of actin monomers (GO:0042989)2.66604239
61positive regulation of synapse maturation (GO:0090129)2.65905834
62neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.65175083
63positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.63880482
64regulation of synapse assembly (GO:0051963)2.60710598
65growth hormone secretion (GO:0030252)2.59174008
66regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.57839191
67protein retention in ER lumen (GO:0006621)2.56640897
68cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.56269193
69regulation of axon guidance (GO:1902667)2.56188815
70membrane repolarization during action potential (GO:0086011)2.55966868
71cerebellum development (GO:0021549)2.55678906
72proline transport (GO:0015824)2.54735006
73ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.54443604
74synaptic vesicle endocytosis (GO:0048488)2.53458985
75establishment of nucleus localization (GO:0040023)2.52769267
76postsynaptic membrane organization (GO:0001941)2.51679067
77macroautophagy (GO:0016236)2.49850127
78limb bud formation (GO:0060174)2.48383533
79sterol biosynthetic process (GO:0016126)2.47780469
80hippocampus development (GO:0021766)2.47091813
81cellular response to glucagon stimulus (GO:0071377)2.46928967
82negative regulation of microtubule polymerization (GO:0031115)2.44517236
83regulation of calcium ion-dependent exocytosis (GO:0017158)2.44134058
84regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.43772620
85negative chemotaxis (GO:0050919)2.43504134
86stress granule assembly (GO:0034063)2.43132011
87G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.42454247
88axon extension (GO:0048675)2.40532833
89regulation of long-term neuronal synaptic plasticity (GO:0048169)2.40337833
90neuron projection extension (GO:1990138)2.40303011
91protein heterotrimerization (GO:0070208)2.39309623
92regulation of vesicle fusion (GO:0031338)2.38951597
93nitric oxide mediated signal transduction (GO:0007263)2.38916647
94olfactory bulb development (GO:0021772)2.38483267
95intraciliary transport (GO:0042073)2.38120523
96inner ear receptor cell development (GO:0060119)2.38043167
97positive regulation of gastrulation (GO:2000543)2.37257273
98body morphogenesis (GO:0010171)2.37147537
99membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.36216754
100positive regulation of synapse assembly (GO:0051965)2.36174841
101cerebellar Purkinje cell differentiation (GO:0021702)2.35123329
102transmission of nerve impulse (GO:0019226)2.34591529
103protein maturation by protein folding (GO:0022417)2.33976973
104cerebral cortex radially oriented cell migration (GO:0021799)2.33537162
105exocrine pancreas development (GO:0031017)2.32751178
106dendritic spine organization (GO:0097061)2.32465371
107C4-dicarboxylate transport (GO:0015740)2.32366620
108synaptic transmission, glutamatergic (GO:0035249)2.32211787
109auditory behavior (GO:0031223)2.31912536
110synapse organization (GO:0050808)2.31280316
111glycosphingolipid biosynthetic process (GO:0006688)2.30964587
112sex determination (GO:0007530)2.30462603
113short-term memory (GO:0007614)2.30351758
114spinal cord development (GO:0021510)2.29753954
115homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.29605671
116vesicle transport along microtubule (GO:0047496)2.29563732
117regulation of male gonad development (GO:2000018)2.28668402
118activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.27463533
119regulation of respiratory system process (GO:0044065)2.26788600
120synapse assembly (GO:0007416)2.26270900
121membrane repolarization (GO:0086009)2.25876288
122central nervous system projection neuron axonogenesis (GO:0021952)2.25441260
123signal release (GO:0023061)2.24934440
124response to auditory stimulus (GO:0010996)2.24678292
125positive regulation of vesicle fusion (GO:0031340)2.24198205
126neuronal action potential propagation (GO:0019227)2.23811015
127neurotransmitter transport (GO:0006836)2.23668852
128negative regulation of axon extension involved in axon guidance (GO:0048843)2.23477979
129chemosensory behavior (GO:0007635)2.23225744
130peptide hormone processing (GO:0016486)2.23093358
131negative regulation of axon extension (GO:0030517)2.22224364
132COPII vesicle coating (GO:0048208)2.22006714
133peptide hormone secretion (GO:0030072)2.21970210
134regulation of insulin secretion (GO:0050796)2.21221851
135neuromuscular process controlling posture (GO:0050884)2.20868434
136protein insertion into membrane (GO:0051205)2.20686971
137organelle transport along microtubule (GO:0072384)2.20344382
138regulation of axon extension involved in axon guidance (GO:0048841)2.18495598
139suckling behavior (GO:0001967)2.18100999
140dopamine receptor signaling pathway (GO:0007212)2.18048003
141regulation of glucocorticoid secretion (GO:2000849)2.17912098
142central nervous system neuron axonogenesis (GO:0021955)2.17673065
143ganglion development (GO:0061548)2.14992745
144regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.14403951
145peptidyl-cysteine modification (GO:0018198)2.13457159
146cilium morphogenesis (GO:0060271)2.13418826
147ephrin receptor signaling pathway (GO:0048013)2.13210449
148appendage development (GO:0048736)2.11491151
149limb development (GO:0060173)2.11491151
150regulation of development, heterochronic (GO:0040034)2.09137893
151protein localization to cilium (GO:0061512)2.08985609
152cerebral cortex cell migration (GO:0021795)2.07132325
153neuronal ion channel clustering (GO:0045161)2.05892820
154cytoskeleton-dependent intracellular transport (GO:0030705)2.05259360
155cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.03965124
156mechanosensory behavior (GO:0007638)2.02821198
157lens fiber cell development (GO:0070307)2.02306652
158regulation of synapse organization (GO:0050807)2.01731658

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.92066956
2GBX2_23144817_ChIP-Seq_PC3_Human2.82352201
3CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.73324395
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73159829
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.70997854
6* EZH2_27304074_Chip-Seq_ESCs_Mouse2.68299940
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.62583725
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.62524966
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.59778998
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53712929
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50617118
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50617118
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40554473
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38068773
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.35807662
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32455716
17REST_21632747_ChIP-Seq_MESCs_Mouse2.25375817
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24175753
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.20788525
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19872409
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.18210732
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10228637
23TRIM28_21343339_ChIP-Seq_HEK293_Human2.03617069
24REST_18959480_ChIP-ChIP_MESCs_Mouse1.98949891
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97617690
26RARB_27405468_Chip-Seq_BRAIN_Mouse1.94380154
27DROSHA_22980978_ChIP-Seq_HELA_Human1.88842345
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.84992529
29ZNF274_21170338_ChIP-Seq_K562_Hela1.84054446
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81628639
31* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.71182365
32IGF1R_20145208_ChIP-Seq_DFB_Human1.70598195
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70373300
34WT1_19549856_ChIP-ChIP_CCG9911_Human1.65677966
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63005874
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61390712
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.57698746
38OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.55305539
39* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55100232
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53666245
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.52345256
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51618770
43NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45994648
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41772495
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41032887
46RING1B_27294783_Chip-Seq_ESCs_Mouse1.39476665
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35735211
48DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.35659210
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34692249
50RING1B_27294783_Chip-Seq_NPCs_Mouse1.34027304
51RNF2_27304074_Chip-Seq_NSC_Mouse1.30205539
52SMAD4_21799915_ChIP-Seq_A2780_Human1.30070231
53* SOX2_21211035_ChIP-Seq_LN229_Gbm1.29244066
54AR_21572438_ChIP-Seq_LNCaP_Human1.28907084
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26173547
56AR_19668381_ChIP-Seq_PC3_Human1.25197009
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25063059
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24802376
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23877433
60EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19654605
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19326364
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19232654
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19066149
64FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17707569
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16494455
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16386354
67KDM2B_26808549_Chip-Seq_K562_Human1.16367730
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15760704
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15656968
70* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15244949
71SOX9_26525672_Chip-Seq_HEART_Mouse1.15165497
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14469513
73FUS_26573619_Chip-Seq_HEK293_Human1.13645046
74ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12593989
75ISL1_27105846_Chip-Seq_CPCs_Mouse1.12545095
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12173240
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11550139
78* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10592010
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.10577189
80EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09922302
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08929744
82SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.08769619
83STAT3_23295773_ChIP-Seq_U87_Human1.08761800
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08714241
85TP53_20018659_ChIP-ChIP_R1E_Mouse1.08669125
86SOX2_16153702_ChIP-ChIP_HESCs_Human1.08488897
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08450357
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08023266
89RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07302391
90TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06654651
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.06530276
92TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06463918
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05771918
94SMAD3_21741376_ChIP-Seq_ESCs_Human1.04669973
95* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04542232
96TP53_18474530_ChIP-ChIP_U2OS_Human1.03632745
97AHR_22903824_ChIP-Seq_MCF-7_Human1.02599846
98HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02133236
99ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00933274
100CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99273546
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99139648
102DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98815768
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98356919
104SMAD3_21741376_ChIP-Seq_EPCs_Human0.97940988
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97353420
106EP300_21415370_ChIP-Seq_HL-1_Mouse0.97305934
107P300_19829295_ChIP-Seq_ESCs_Human0.97067302
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95612778
109CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94287353
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92740372
111AR_25329375_ChIP-Seq_VCAP_Human0.92585181
112TAF15_26573619_Chip-Seq_HEK293_Human0.92565470
113TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91059056
114* SMAD4_21741376_ChIP-Seq_HESCs_Human0.89462803
115POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89457649
116* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89133495
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88645898
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88410034
119TET1_21490601_ChIP-Seq_MESCs_Mouse0.88274731
120EWS_26573619_Chip-Seq_HEK293_Human0.87673589
121* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.87498418
122* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86734047
123TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86547519
124HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85868739
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85862635
126ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85161238
127HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85107975
128* RUNX2_22187159_ChIP-Seq_PCA_Human0.84658031
129TCF4_23295773_ChIP-Seq_U87_Human0.84456292
130SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.83726662
131SALL1_21062744_ChIP-ChIP_HESCs_Human0.83508481
132POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83433192

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.35585193
2MP0004859_abnormal_synaptic_plasticity3.33772876
3MP0009780_abnormal_chondrocyte_physiolo2.88637696
4MP0003283_abnormal_digestive_organ2.84377806
5MP0001529_abnormal_vocalization2.80137217
6MP0008438_abnormal_cutaneous_collagen2.53956039
7MP0002909_abnormal_adrenal_gland2.42978791
8MP0005645_abnormal_hypothalamus_physiol2.40463691
9MP0003635_abnormal_synaptic_transmissio2.38839326
10MP0000013_abnormal_adipose_tissue2.35961967
11MP0003121_genomic_imprinting2.34566692
12MP0004270_analgesia2.23269864
13MP0003123_paternal_imprinting2.17781090
14MP0002063_abnormal_learning/memory/cond2.05646991
15MP0003880_abnormal_central_pattern2.05327362
16MP0010386_abnormal_urinary_bladder2.05043332
17MP0008789_abnormal_olfactory_epithelium2.00325803
18MP0003787_abnormal_imprinting1.95116932
19MP0000778_abnormal_nervous_system1.78011495
20MP0004858_abnormal_nervous_system1.69404433
21MP0002572_abnormal_emotion/affect_behav1.67090223
22MP0005646_abnormal_pituitary_gland1.66932802
23MP0002184_abnormal_innervation1.65396951
24MP0000566_synostosis1.60129300
25MP0002734_abnormal_mechanical_nocicepti1.59080487
26MP0005423_abnormal_somatic_nervous1.58978893
27MP0009745_abnormal_behavioral_response1.57424894
28MP0004133_heterotaxia1.54499056
29MP0002733_abnormal_thermal_nociception1.52838797
30MP0002064_seizures1.52531561
31MP0002102_abnormal_ear_morphology1.51842831
32MP0000678_abnormal_parathyroid_gland1.51065391
33MP0000631_abnormal_neuroendocrine_gland1.50123648
34MP0002557_abnormal_social/conspecific_i1.47719224
35MP0000569_abnormal_digit_pigmentation1.45961481
36MP0005257_abnormal_intraocular_pressure1.45090142
37MP0002837_dystrophic_cardiac_calcinosis1.44631619
38MP0009384_cardiac_valve_regurgitation1.41879330
39* MP0006276_abnormal_autonomic_nervous1.40574558
40MP0002822_catalepsy1.39832738
41MP0000955_abnormal_spinal_cord1.36419644
42MP0003942_abnormal_urinary_system1.34291710
43MP0001968_abnormal_touch/_nociception1.34013468
44MP0004233_abnormal_muscle_weight1.33705565
45MP0002233_abnormal_nose_morphology1.33364487
46MP0001944_abnormal_pancreas_morphology1.33081715
47MP0009046_muscle_twitch1.32793048
48MP0002234_abnormal_pharynx_morphology1.32068113
49MP0008961_abnormal_basal_metabolism1.31939817
50MP0002653_abnormal_ependyma_morphology1.31794497
51MP0003119_abnormal_digestive_system1.30387553
52MP0002272_abnormal_nervous_system1.29515854
53MP0000537_abnormal_urethra_morphology1.29314973
54MP0005503_abnormal_tendon_morphology1.29095683
55MP0000534_abnormal_ureter_morphology1.27985675
56MP0006072_abnormal_retinal_apoptosis1.27358800
57MP0004043_abnormal_pH_regulation1.25097039
58MP0005171_absent_coat_pigmentation1.24967287
59* MP0004811_abnormal_neuron_physiology1.24962570
60MP0001299_abnormal_eye_distance/1.24689085
61MP0001984_abnormal_olfaction1.23906130
62MP0001440_abnormal_grooming_behavior1.22626493
63MP0003183_abnormal_peptide_metabolism1.20281973
64MP0003879_abnormal_hair_cell1.19459737
65MP0001970_abnormal_pain_threshold1.19423602
66MP0000003_abnormal_adipose_tissue1.18494096
67MP0005187_abnormal_penis_morphology1.15528978
68MP0000751_myopathy1.15515013
69MP0003937_abnormal_limbs/digits/tail_de1.15425890
70MP0003385_abnormal_body_wall1.13979726
71MP0003136_yellow_coat_color1.12055154
72MP0008995_early_reproductive_senescence1.11943764
73MP0001502_abnormal_circadian_rhythm1.11472926
74MP0002882_abnormal_neuron_morphology1.10034611
75MP0000026_abnormal_inner_ear1.09032717
76MP0002282_abnormal_trachea_morphology1.08743423
77MP0002067_abnormal_sensory_capabilities1.08090235
78MP0002638_abnormal_pupillary_reflex1.07934196
79MP0002896_abnormal_bone_mineralization1.07547730
80MP0002877_abnormal_melanocyte_morpholog1.06852373
81MP0010030_abnormal_orbit_morphology1.06746546
82MP0001486_abnormal_startle_reflex1.06573552
83MP0004145_abnormal_muscle_electrophysio1.06183733
84MP0002735_abnormal_chemical_nociception1.05979776
85MP0001958_emphysema1.03328014
86MP0005379_endocrine/exocrine_gland_phen1.01866643
87MP0001177_atelectasis1.01736351
88MP0009250_abnormal_appendicular_skeleto1.01181893
89MP0003938_abnormal_ear_development1.00770692
90MP0002697_abnormal_eye_size1.00129456
91MP0002752_abnormal_somatic_nervous0.99902548
92MP0002152_abnormal_brain_morphology0.98672070
93MP0004272_abnormal_basement_membrane0.97807913
94MP0004142_abnormal_muscle_tone0.96986765
95MP0001501_abnormal_sleep_pattern0.96264584
96MP0003890_abnormal_embryonic-extraembry0.95351674
97MP0005275_abnormal_skin_tensile0.94032984
98MP0004885_abnormal_endolymph0.93619149
99MP0003195_calcinosis0.93342612
100MP0002693_abnormal_pancreas_physiology0.92873298
101MP0000049_abnormal_middle_ear0.90767950
102MP0008877_abnormal_DNA_methylation0.90644262
103MP0005623_abnormal_meninges_morphology0.90361791
104MP0006292_abnormal_olfactory_placode0.89174551
105MP0004924_abnormal_behavior0.88896661
106MP0005386_behavior/neurological_phenoty0.88896661
107MP0002295_abnormal_pulmonary_circulatio0.87868540
108MP0001293_anophthalmia0.87722543
109MP0001270_distended_abdomen0.87344358
110* MP0002751_abnormal_autonomic_nervous0.87042992
111MP0002066_abnormal_motor_capabilities/c0.86540056
112MP0003011_delayed_dark_adaptation0.85711172
113MP0003115_abnormal_respiratory_system0.85111927
114MP0005508_abnormal_skeleton_morphology0.84832323
115MP0005551_abnormal_eye_electrophysiolog0.84602110
116MP0003861_abnormal_nervous_system0.84224482
117MP0002249_abnormal_larynx_morphology0.83571550
118MP0003329_amyloid_beta_deposits0.83566036
119MP0005248_abnormal_Harderian_gland0.83479128
120MP0002069_abnormal_eating/drinking_beha0.82333548
121MP0000462_abnormal_digestive_system0.81987967
122MP0003935_abnormal_craniofacial_develop0.81452577
123MP0000538_abnormal_urinary_bladder0.81054785
124MP0002938_white_spotting0.80895621
125MP0002116_abnormal_craniofacial_bone0.80562689
126MP0002736_abnormal_nociception_after0.80495352
127MP0005499_abnormal_olfactory_system0.77976622
128MP0005394_taste/olfaction_phenotype0.77976622
129MP0005220_abnormal_exocrine_pancreas0.76184084
130MP0008569_lethality_at_weaning0.75139498
131MP0003755_abnormal_palate_morphology0.75109027
132MP0002078_abnormal_glucose_homeostasis0.73807896

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.14485280
2Agitation (HP:0000713)3.66146002
3Failure to thrive in infancy (HP:0001531)3.57886739
4Premature rupture of membranes (HP:0001788)3.26199898
5Focal motor seizures (HP:0011153)2.94687069
6Visual hallucinations (HP:0002367)2.93468986
7Hypoventilation (HP:0002791)2.90801216
8Neoplasm of the heart (HP:0100544)2.79960972
9Ankle clonus (HP:0011448)2.67871972
10Myokymia (HP:0002411)2.63882836
11Hypoglycemic seizures (HP:0002173)2.63647482
12Pheochromocytoma (HP:0002666)2.63525045
13Cortical dysplasia (HP:0002539)2.59004132
14Focal seizures (HP:0007359)2.57077011
15Congenital primary aphakia (HP:0007707)2.53982840
16Hyperinsulinemic hypoglycemia (HP:0000825)2.52603565
17Abnormality of calcium-phosphate metabolism (HP:0100530)2.51624418
18EEG with generalized epileptiform discharges (HP:0011198)2.50587695
19Protrusio acetabuli (HP:0003179)2.46144489
20Hypsarrhythmia (HP:0002521)2.45514091
21Epileptiform EEG discharges (HP:0011182)2.45455553
22Renal duplication (HP:0000075)2.45353272
23Medial flaring of the eyebrow (HP:0010747)2.42873903
24Nephrogenic diabetes insipidus (HP:0009806)2.38962499
25Hepatoblastoma (HP:0002884)2.37826797
26Retinal dysplasia (HP:0007973)2.37777875
27Testicular neoplasm (HP:0010788)2.34914983
28Epileptic encephalopathy (HP:0200134)2.31817834
29Occipital encephalocele (HP:0002085)2.30829847
30Depression (HP:0000716)2.29891792
31Symptomatic seizures (HP:0011145)2.29528790
32Polyphagia (HP:0002591)2.26982239
33Macroorchidism (HP:0000053)2.26974596
34Atonic seizures (HP:0010819)2.26469438
35Vaginal atresia (HP:0000148)2.20107963
36Abnormality of the labia minora (HP:0012880)2.16614063
37Menstrual irregularities (HP:0000858)2.16506564
38Genital tract atresia (HP:0001827)2.15318256
39Insomnia (HP:0100785)2.13545786
40Excessive salivation (HP:0003781)2.13315687
41Drooling (HP:0002307)2.13315687
42Neuroendocrine neoplasm (HP:0100634)2.12983501
43Hypercortisolism (HP:0001578)2.09445297
44Progressive cerebellar ataxia (HP:0002073)2.07178006
45Infantile muscular hypotonia (HP:0008947)2.05000975
46True hermaphroditism (HP:0010459)2.04849928
47Limb dystonia (HP:0002451)2.03632591
48Split foot (HP:0001839)2.03075696
49Soft skin (HP:0000977)2.02796105
50Absence seizures (HP:0002121)2.02473086
51Generalized tonic-clonic seizures (HP:0002069)2.01589547
52Shoulder girdle muscle weakness (HP:0003547)2.01476336
53Congenital glaucoma (HP:0001087)2.00116880
54Abnormal pancreas size (HP:0012094)2.00028085
55Abnormal eating behavior (HP:0100738)1.99050109
56Abnormality of the lower motor neuron (HP:0002366)1.98984908
57Increased corneal curvature (HP:0100692)1.98952699
58Keratoconus (HP:0000563)1.98952699
59Neonatal short-limb short stature (HP:0008921)1.98901238
60Vitreoretinal degeneration (HP:0000655)1.98186450
61Hand muscle atrophy (HP:0009130)1.94469013
62Amyotrophic lateral sclerosis (HP:0007354)1.93789163
63Follicular hyperkeratosis (HP:0007502)1.93490188
64Megalencephaly (HP:0001355)1.91360443
65Broad foot (HP:0001769)1.90917225
66Exotropia (HP:0000577)1.90799180
67Hyperacusis (HP:0010780)1.90250149
68Narrow nasal bridge (HP:0000446)1.90240543
69Amblyopia (HP:0000646)1.89399803
70Bladder diverticulum (HP:0000015)1.87184763
71Postaxial hand polydactyly (HP:0001162)1.86546749
72Supranuclear gaze palsy (HP:0000605)1.86366683
73Coronal craniosynostosis (HP:0004440)1.86283339
74Pachygyria (HP:0001302)1.85285456
75Hemiparesis (HP:0001269)1.83282752
76Labial hypoplasia (HP:0000066)1.82956581
77Wide anterior fontanel (HP:0000260)1.82045224
78Anxiety (HP:0000739)1.79204208
79Truncal ataxia (HP:0002078)1.79039394
80Delayed gross motor development (HP:0002194)1.77719597
81Restlessness (HP:0000711)1.77664379
82Poor suck (HP:0002033)1.77178649
83Open mouth (HP:0000194)1.76397590
84Bowel diverticulosis (HP:0005222)1.76100199
85Hyperglycemia (HP:0003074)1.75773982
86Hypoplastic pelvis (HP:0008839)1.75457033
87Morphological abnormality of the middle ear (HP:0008609)1.74541641
88Limb-girdle muscle weakness (HP:0003325)1.74083461
89Elfin facies (HP:0004428)1.73769375
90Hyperthyroidism (HP:0000836)1.72676825
91Aplasia/Hypoplasia of the lens (HP:0008063)1.72251598
92Cerebral aneurysm (HP:0004944)1.71383596
93Renovascular hypertension (HP:0100817)1.71261957
94Aplasia/Hypoplasia of the brainstem (HP:0007362)1.70646825
95Hypoplasia of the brainstem (HP:0002365)1.70646825
96Oligomenorrhea (HP:0000876)1.70544510
97Ankle contracture (HP:0006466)1.70424488
98Ankyloglossia (HP:0010296)1.70384742
99Action tremor (HP:0002345)1.69420396
100Trigonocephaly (HP:0000243)1.69328213
101Broad metatarsal (HP:0001783)1.69279569
102Atrophy/Degeneration involving motor neurons (HP:0007373)1.68506682
103Turricephaly (HP:0000262)1.68408074
104Papillary thyroid carcinoma (HP:0002895)1.68186555
105Absent speech (HP:0001344)1.67634198
106Impaired pain sensation (HP:0007328)1.66027183
107Abnormality of pain sensation (HP:0010832)1.66027183
108Dialeptic seizures (HP:0011146)1.65490612
109Pointed chin (HP:0000307)1.65488539
110Aortic dissection (HP:0002647)1.65402463
111Decreased testicular size (HP:0008734)1.64756375
112Bronchomalacia (HP:0002780)1.64068861
113Buphthalmos (HP:0000557)1.63891361
114Bifid tongue (HP:0010297)1.63500453
115Pancreatic fibrosis (HP:0100732)1.63162508
116Sleep apnea (HP:0010535)1.61361578
117Papilledema (HP:0001085)1.60910497
118Insulin-resistant diabetes mellitus (HP:0000831)1.60877197
119Spastic tetraplegia (HP:0002510)1.60676980
120Large for gestational age (HP:0001520)1.60355495
121Abnormality of the pancreatic islet cells (HP:0006476)1.60047903
122Abnormality of endocrine pancreas physiology (HP:0012093)1.60047903
123Heterochromia iridis (HP:0001100)1.59838780
124Poor coordination (HP:0002370)1.59545678
125Renal hypoplasia (HP:0000089)1.59209239
126Specific learning disability (HP:0001328)1.59130234
127Wrist flexion contracture (HP:0001239)1.58983824
128Torticollis (HP:0000473)1.58763528
129Gait imbalance (HP:0002141)1.58209570
130Narrow forehead (HP:0000341)1.58026472
131Micropenis (HP:0000054)1.57999747
132Cutaneous finger syndactyly (HP:0010554)1.57362462
133Abnormality of the musculature of the pelvis (HP:0001469)1.56935941
134Abnormality of the hip-girdle musculature (HP:0001445)1.56935941
135Long toe (HP:0010511)1.55139842
136Clonus (HP:0002169)1.54535694
137Type II lissencephaly (HP:0007260)1.54414514
138Neoplasm of the peripheral nervous system (HP:0100007)1.54043891
139Lissencephaly (HP:0001339)1.54015480
140Distal upper limb amyotrophy (HP:0007149)1.53811732
141Upper limb amyotrophy (HP:0009129)1.53811732
142Postural tremor (HP:0002174)1.53520640
143Lymphangioma (HP:0100764)1.53335770
144Short foot (HP:0001773)1.53320576
145Hyperparathyroidism (HP:0000843)1.53257432
146Enlarged penis (HP:0000040)1.53109498
147Abnormality of dentin (HP:0010299)1.52757906
148Renal dysplasia (HP:0000110)1.52715753
149Shallow orbits (HP:0000586)1.52513582
150Hyperglycinemia (HP:0002154)1.51640813
151Hypoplastic female external genitalia (HP:0012815)1.51484856
152Humeroradial synostosis (HP:0003041)1.51045834
153Synostosis involving the elbow (HP:0003938)1.51045834
154Anteriorly placed anus (HP:0001545)1.50967668
155Short 4th metacarpal (HP:0010044)1.50090826
156Anterior segment dysgenesis (HP:0007700)1.49790488
157Cutaneous syndactyly (HP:0012725)1.49134298
158Generalized hypotonia (HP:0001290)1.47541080
159Postaxial foot polydactyly (HP:0001830)1.46377044
160Dental crowding (HP:0000678)1.45391443
161Intestinal atresia (HP:0011100)1.44938079
162Vascular tortuosity (HP:0004948)1.44924904
163Nephronophthisis (HP:0000090)1.44744271
164Decreased muscle mass (HP:0003199)1.43841003

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.88881180
2NTRK33.45496485
3MARK13.18690403
4PRKD32.98409980
5MAP3K42.58953680
6MAP4K22.56348860
7INSRR2.35626783
8MAP3K92.27143715
9MINK12.17779597
10KSR12.01455093
11UHMK11.95900277
12PDGFRA1.86656301
13NTRK21.86562347
14TRIM281.82302635
15EPHB21.77252007
16NTRK11.76708948
17BCKDK1.70257918
18PASK1.68557189
19CSNK1G11.64503149
20PAK61.63307786
21MAP2K71.63053380
22PAK31.49852995
23MAP3K21.49453767
24FER1.48388514
25SIK31.43469459
26TYRO31.41391078
27NEK11.40693730
28MAPK151.40362326
29CASK1.38975931
30EPHA41.37285350
31ERBB31.36312191
32TRIB31.33199064
33DAPK21.31535069
34BCR1.31174021
35LATS21.29119370
36KSR21.28571847
37MAP2K41.28039195
38MAPK131.28020313
39CDC42BPA1.21837690
40CDK51.16393850
41ICK1.14751760
42DDR21.12205563
43CDK191.04601878
44PLK21.03508322
45PHKG10.98394382
46PHKG20.98394382
47LMTK20.96312826
48RET0.96116258
49PINK10.95417727
50PRKCH0.94532339
51DYRK30.94138233
52SCYL20.93736926
53EPHB10.93637780
54MAP3K120.93298539
55PTK20.91488170
56WNK40.90485672
57SRPK10.90259605
58CAMKK10.89918284
59DYRK20.89678831
60SGK4940.89600035
61SGK2230.89600035
62STK38L0.88866960
63PRKCG0.88449969
64LIMK10.87958812
65RPS6KA20.87536818
66EPHA30.86179932
67AKT30.85142084
68HIPK20.80541943
69PTK60.79071627
70PIM20.78833205
71CAMK1G0.77692584
72CDK180.77400194
73CDK140.75683285
74LATS10.75353865
75DAPK10.74694722
76ROCK20.73315442
77PNCK0.72807729
78RIPK10.72711157
79ERBB20.72319105
80DYRK1A0.70117035
81CSNK1G20.69355830
82SGK20.68886623
83ERBB40.68576383
84CDK150.67992607
85TNIK0.66970666
86MARK20.66336137
87PRKCE0.62985109
88PKN10.62702536
89MAP3K10.62133312
90CAMK2B0.61721372
91FLT30.60727546
92FGFR10.59855113
93STK380.59779150
94SIK10.58404591
95MAP2K10.58120764
96PRPF4B0.57627679
97ROCK10.57043613
98BRD40.56311493
99PAK20.56030135
100CDK11A0.55598004
101CAMKK20.54824869
102CAMK2A0.54590562
103MTOR0.54071927
104RPS6KA40.53486994
105CSNK1A1L0.52883288
106CAMK2G0.52642695
107SIK20.52218409
108MYLK0.52098062
109SGK30.50691082
110WNK10.50637942
111PRKCZ0.50434576
112ADRBK10.50146319
113DYRK1B0.49919926
114BRAF0.49279091
115PKN20.47905932
116BRSK10.47433540
117FGFR20.47200472
118FRK0.46549846
119NEK90.46277205
120GRK50.45488887
121TESK10.45284403
122CSNK1A10.43624862
123CAMK2D0.43489742
124CSNK1G30.43198167
125TESK20.42608836
126ARAF0.42069394
127CSNK1D0.41735215
128SGK10.40627181
129TSSK60.39690445
130MUSK0.38683410
131PRKAA10.38523943
132VRK20.35958436
133PRKD20.35791220
134CCNB10.35615585
135AKT20.34320521
136BMPR1B0.33342913
137PLK30.33316105
138GRK10.32701845

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.98402299
2Synaptic vesicle cycle_Homo sapiens_hsa047212.76296446
3Insulin secretion_Homo sapiens_hsa049112.67831907
4Steroid biosynthesis_Homo sapiens_hsa001002.59876250
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.54879961
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.50031599
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.48953662
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.43743481
9Nicotine addiction_Homo sapiens_hsa050332.29052078
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.25994609
11GABAergic synapse_Homo sapiens_hsa047272.16927841
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.09101330
13Amphetamine addiction_Homo sapiens_hsa050312.02383439
14Circadian entrainment_Homo sapiens_hsa047132.02156546
15Cocaine addiction_Homo sapiens_hsa050302.01540898
16Dopaminergic synapse_Homo sapiens_hsa047281.99782180
17Vibrio cholerae infection_Homo sapiens_hsa051101.94237483
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.79561080
19Long-term potentiation_Homo sapiens_hsa047201.76914285
20Type II diabetes mellitus_Homo sapiens_hsa049301.69739065
21Morphine addiction_Homo sapiens_hsa050321.68169838
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62561125
23Cholinergic synapse_Homo sapiens_hsa047251.59997483
24Glutamatergic synapse_Homo sapiens_hsa047241.55237817
25Taste transduction_Homo sapiens_hsa047421.53904003
26Olfactory transduction_Homo sapiens_hsa047401.51119119
27Fatty acid elongation_Homo sapiens_hsa000621.48852828
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.48144828
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47752962
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44882018
31Axon guidance_Homo sapiens_hsa043601.43874558
32Gap junction_Homo sapiens_hsa045401.43146314
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42219007
34Renin secretion_Homo sapiens_hsa049241.39110081
35Serotonergic synapse_Homo sapiens_hsa047261.36228000
36Collecting duct acid secretion_Homo sapiens_hsa049661.33945019
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.31823640
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30915257
39Estrogen signaling pathway_Homo sapiens_hsa049151.28197978
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26100713
41Melanogenesis_Homo sapiens_hsa049161.24618279
42Long-term depression_Homo sapiens_hsa047301.24492400
43Hedgehog signaling pathway_Homo sapiens_hsa043401.22266457
44Gastric acid secretion_Homo sapiens_hsa049711.17665518
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14842362
46Propanoate metabolism_Homo sapiens_hsa006401.14467438
47Oxytocin signaling pathway_Homo sapiens_hsa049211.14134189
48Salivary secretion_Homo sapiens_hsa049701.12358352
49Fatty acid metabolism_Homo sapiens_hsa012121.12175484
50Type I diabetes mellitus_Homo sapiens_hsa049401.11028754
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10025707
52GnRH signaling pathway_Homo sapiens_hsa049121.08685476
53Glioma_Homo sapiens_hsa052141.04776086
54Biosynthesis of amino acids_Homo sapiens_hsa012301.04313856
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04155746
56N-Glycan biosynthesis_Homo sapiens_hsa005101.01811991
57cAMP signaling pathway_Homo sapiens_hsa040241.01777901
58Phototransduction_Homo sapiens_hsa047441.00883886
59ECM-receptor interaction_Homo sapiens_hsa045121.00413058
60Oxidative phosphorylation_Homo sapiens_hsa001901.00121314
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99017562
62Endometrial cancer_Homo sapiens_hsa052130.98610931
63Protein export_Homo sapiens_hsa030600.98411596
64Glucagon signaling pathway_Homo sapiens_hsa049220.98113314
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97490907
66Thyroid hormone synthesis_Homo sapiens_hsa049180.96914426
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96737737
68Parkinsons disease_Homo sapiens_hsa050120.95464733
69Arginine and proline metabolism_Homo sapiens_hsa003300.93737545
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92021119
71Dilated cardiomyopathy_Homo sapiens_hsa054140.91663496
72Oocyte meiosis_Homo sapiens_hsa041140.90325436
73ErbB signaling pathway_Homo sapiens_hsa040120.89432431
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88843859
75Hippo signaling pathway_Homo sapiens_hsa043900.85846339
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85782954
77Basal cell carcinoma_Homo sapiens_hsa052170.85580198
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.85544114
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85312445
80Calcium signaling pathway_Homo sapiens_hsa040200.85121230
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84976950
82Wnt signaling pathway_Homo sapiens_hsa043100.84378827
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84177108
84mTOR signaling pathway_Homo sapiens_hsa041500.83164776
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.82006814
86Alcoholism_Homo sapiens_hsa050340.82003232
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81749603
88Dorso-ventral axis formation_Homo sapiens_hsa043200.81381976
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81349084
90Insulin signaling pathway_Homo sapiens_hsa049100.81196281
91Peroxisome_Homo sapiens_hsa041460.81020590
92Prion diseases_Homo sapiens_hsa050200.80849371
93Carbon metabolism_Homo sapiens_hsa012000.78930916
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78043540
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78003773
96Pancreatic secretion_Homo sapiens_hsa049720.77590466
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76588710
98Huntingtons disease_Homo sapiens_hsa050160.73208985
99beta-Alanine metabolism_Homo sapiens_hsa004100.73170133
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72234472
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68755617
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68608501
103* Neurotrophin signaling pathway_Homo sapiens_hsa047220.67342368
104Pyruvate metabolism_Homo sapiens_hsa006200.66053361
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65812555
106Alzheimers disease_Homo sapiens_hsa050100.65383773
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65115188
108Ovarian steroidogenesis_Homo sapiens_hsa049130.64868323
109Circadian rhythm_Homo sapiens_hsa047100.64036776
110Colorectal cancer_Homo sapiens_hsa052100.63996103
111Renal cell carcinoma_Homo sapiens_hsa052110.63000006
112Butanoate metabolism_Homo sapiens_hsa006500.61717777
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60913379
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60787096
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59315151
116AMPK signaling pathway_Homo sapiens_hsa041520.57633761
117Protein digestion and absorption_Homo sapiens_hsa049740.57350773
118Focal adhesion_Homo sapiens_hsa045100.55216320
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.55111504
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54771376
121Prolactin signaling pathway_Homo sapiens_hsa049170.54640401
122Sulfur relay system_Homo sapiens_hsa041220.53908105
123TGF-beta signaling pathway_Homo sapiens_hsa043500.53699773
124Cardiac muscle contraction_Homo sapiens_hsa042600.52468463
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52365478
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52064623
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51963418
128MAPK signaling pathway_Homo sapiens_hsa040100.50972848
129Insulin resistance_Homo sapiens_hsa049310.50311110
130Sulfur metabolism_Homo sapiens_hsa009200.49704050
131Choline metabolism in cancer_Homo sapiens_hsa052310.48940096
132Tight junction_Homo sapiens_hsa045300.48592891
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.47756315
134Ras signaling pathway_Homo sapiens_hsa040140.46926466
135Adherens junction_Homo sapiens_hsa045200.46799728
136Endocytosis_Homo sapiens_hsa041440.46170551
137Metabolic pathways_Homo sapiens_hsa011000.45595554
138Proteoglycans in cancer_Homo sapiens_hsa052050.43841341
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.43138851
140Vitamin B6 metabolism_Homo sapiens_hsa007500.41071091
141Lysine degradation_Homo sapiens_hsa003100.40930581
142Fat digestion and absorption_Homo sapiens_hsa049750.38529626
143Ether lipid metabolism_Homo sapiens_hsa005650.37604860
144Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36936286

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