ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	7.08889156
2	nucleobase catabolic process (GO:0046113)	5.49600460
3	postsynaptic membrane organization (GO:0001941)	5.16713111
4	presynaptic membrane assembly (GO:0097105)	5.09576795
5	neuron cell-cell adhesion (GO:0007158)	4.65848805
6	presynaptic membrane organization (GO:0097090)	4.54308874
7	axonal fasciculation (GO:0007413)	4.37704732
8	neuron recognition (GO:0008038)	4.06644034
9	auditory behavior (GO:0031223)	4.00487183
10	protein localization to synapse (GO:0035418)	3.99068752
11	establishment of mitochondrion localization (GO:0051654)	3.92243489
12	dendritic spine morphogenesis (GO:0060997)	3.87029791
13	retinal ganglion cell axon guidance (GO:0031290)	3.84365581
14	vocalization behavior (GO:0071625)	3.82755629
15	gamma-aminobutyric acid transport (GO:0015812)	3.75720669
16	positive regulation of synapse assembly (GO:0051965)	3.61316442
17	synapse assembly (GO:0007416)	3.57388963
18	cell proliferation in forebrain (GO:0021846)	3.54173985
19	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.52984005
20	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.48004169
21	cell migration in hindbrain (GO:0021535)	3.45790899
22	neurotransmitter-gated ion channel clustering (GO:0072578)	3.32359667
23	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.30612716
24	limb bud formation (GO:0060174)	3.30398402
25	nonmotile primary cilium assembly (GO:0035058)	3.27542704
26	negative regulation of axon guidance (GO:1902668)	3.27031347
27	central nervous system projection neuron axonogenesis (GO:0021952)	3.24122333
28	transmission of nerve impulse (GO:0019226)	3.21031172
29	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.20101408
30	response to auditory stimulus (GO:0010996)	3.19652612
31	sulfation (GO:0051923)	3.18473238
32	spinal cord development (GO:0021510)	3.14896116
33	mechanosensory behavior (GO:0007638)	3.14811919
34	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.14793935
35	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	3.13005343
36	positive regulation of mitochondrial fission (GO:0090141)	3.12599960
37	layer formation in cerebral cortex (GO:0021819)	3.11909910
38	dendrite morphogenesis (GO:0048813)	2.99781698
39	behavioral response to nicotine (GO:0035095)	2.99429642
40	sequestering of actin monomers (GO:0042989)	2.98197819
41	olfactory bulb development (GO:0021772)	2.94430992
42	dermatan sulfate biosynthetic process (GO:0030208)	2.93907081
43	axon extension (GO:0048675)	2.93522850
44	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.93467885
45	axon extension involved in axon guidance (GO:0048846)	2.93467885
46	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.89627886
47	regulation of respiratory system process (GO:0044065)	2.86852570
48	neuronal stem cell maintenance (GO:0097150)	2.84465553
49	hippocampus development (GO:0021766)	2.84033993
50	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.83267280
51	regulation of axon guidance (GO:1902667)	2.81021012
52	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.80962918
53	synaptic vesicle maturation (GO:0016188)	2.80109557
54	somite development (GO:0061053)	2.78800634
55	protein polyglutamylation (GO:0018095)	2.77208114
56	positive regulation of gastrulation (GO:2000543)	2.75131646
57	regulation of synapse structural plasticity (GO:0051823)	2.75126453
58	regulation of development, heterochronic (GO:0040034)	2.74896368
59	synapse organization (GO:0050808)	2.74241608
60	forebrain neuron differentiation (GO:0021879)	2.73598210
61	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.73436145
62	synaptic transmission, glutamatergic (GO:0035249)	2.72492331
63	regulation of synapse assembly (GO:0051963)	2.72199729
64	cerebral cortex radially oriented cell migration (GO:0021799)	2.72053549
65	head development (GO:0060322)	2.70377834
66	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.68938911
67	mitochondrion transport along microtubule (GO:0047497)	2.68938911
68	negative chemotaxis (GO:0050919)	2.64133651
69	negative regulation of axon extension (GO:0030517)	2.63162539
70	negative regulation of glial cell differentiation (GO:0045686)	2.62494796
71	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.60744874
72	dermatan sulfate metabolic process (GO:0030205)	2.60590737
73	central nervous system neuron axonogenesis (GO:0021955)	2.58197988
74	lateral sprouting from an epithelium (GO:0060601)	2.57164133
75	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)	2.56855663
76	homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)	2.56307919
77	protein localization to cilium (GO:0061512)	2.55942967
78	axonogenesis (GO:0007409)	2.52562830
79	synaptic vesicle exocytosis (GO:0016079)	2.51916607
80	neurofilament cytoskeleton organization (GO:0060052)	2.50112789
81	DNA integration (GO:0015074)	2.50057895
82	regulation of somitogenesis (GO:0014807)	2.49903191
83	neuron projection extension (GO:1990138)	2.48202357
84	glutamate receptor signaling pathway (GO:0007215)	2.46861962
85	neuronal action potential propagation (GO:0019227)	2.45322142
86	regulation of timing of cell differentiation (GO:0048505)	2.43031982
87	regulation of axon extension involved in axon guidance (GO:0048841)	2.42729179
88	negative regulation of telomere maintenance (GO:0032205)	2.42256428
89	neuron migration (GO:0001764)	2.41821744
90	ganglion development (GO:0061548)	2.41684835
91	limb development (GO:0060173)	2.40969784
92	appendage development (GO:0048736)	2.40969784
93	synaptic vesicle endocytosis (GO:0048488)	2.40936378
94	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.40383461
95	nervous system development (GO:0007399)	2.39183955
96	pyrimidine dimer repair (GO:0006290)	2.38654034
97	positive regulation of synapse maturation (GO:0090129)	2.38119348
98	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.38079502
99	startle response (GO:0001964)	2.37288749
100	negative regulation of astrocyte differentiation (GO:0048712)	2.36605983

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.43892480
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	4.00411845
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.07553442
4	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.95173462
5	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.88184445
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.78871527
7	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.77300501
8	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.73486117
9	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.57993637
10	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.57086003
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.49109957
12	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.39405424
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.37490868
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.33564767
15	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.26386874
16	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.26016942
17	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.22131736
18	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.07142682
19	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.07142682
20	REST_21632747_ChIP-Seq_MESCs_Mouse	2.05746469
21	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	2.03040316
22	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.00420143
23	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.98214546
24	RNF2_27304074_Chip-Seq_NSC_Mouse	1.95903859
25	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.95723447
26	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.90619474
27	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.86963098
28	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.82493144
29	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.81448632
30	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.80666682
31	TAF15_26573619_Chip-Seq_HEK293_Human	1.80617012
32	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.77600835
33	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.73385147
34	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.72989924
35	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.70268632
36	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.70255474
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.59016387
38	FUS_26573619_Chip-Seq_HEK293_Human	1.56009380
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.53337752
40	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.50331982
41	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.47228203
42	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43725150
43	P300_19829295_ChIP-Seq_ESCs_Human	1.42029351
44	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.41297201
45	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.39596982
46	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.36906244
47	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.34541067
48	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.32868657
49	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.30891769
50	EWS_26573619_Chip-Seq_HEK293_Human	1.30599152
51	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.25165552
52	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22200548
53	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.21516882
54	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.21353667
55	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.19334825
56	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.18448628
57	IRF1_19129219_ChIP-ChIP_H3396_Human	1.18399804
58	SMAD4_21799915_ChIP-Seq_A2780_Human	1.18020016
59	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.17108615
60	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.16583988
61	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.14987211
62	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.14572796
63	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.13488700
64	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13488700
65	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.12749145
66	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.12593843
67	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.12587198
68	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.12214537
69	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.11226487
70	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.10563278
71	SOX9_26525672_Chip-Seq_HEART_Mouse	1.10505968
72	DROSHA_22980978_ChIP-Seq_HELA_Human	1.08594664
73	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.05759040
74	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.03853689
75	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.03341691
76	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.03176207
77	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	1.01908279
78	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.01569207
79	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.00591727
80	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.99595999
81	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.98789275
82	AR_21572438_ChIP-Seq_LNCaP_Human	0.97352366
83	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.94876809
84	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.93939921
85	* AR_19668381_ChIP-Seq_PC3_Human	0.93006420
86	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.92710325
87	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.92471171
88	JUN_21703547_ChIP-Seq_K562_Human	0.92108754
89	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.91950000
90	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.91746879
91	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.91453630
92	CBP_20019798_ChIP-Seq_JUKART_Human	0.90443354
93	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.90443354
94	STAT3_23295773_ChIP-Seq_U87_Human	0.90316283
95	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.89314353
96	AR_25329375_ChIP-Seq_VCAP_Human	0.89128161
97	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.88225998
98	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.85898787
99	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.85847629
100	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.85266201

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003122_maternal_imprinting	3.21830151
2	MP0004859_abnormal_synaptic_plasticity	2.97220696
3	MP0001529_abnormal_vocalization	2.91910944
4	MP0000778_abnormal_nervous_system	2.88002027
5	MP0003880_abnormal_central_pattern	2.79401219
6	MP0004270_analgesia	2.58210948
7	MP0006292_abnormal_olfactory_placode	2.25030426
8	MP0000049_abnormal_middle_ear	2.20310093
9	MP0006276_abnormal_autonomic_nervous	2.17264842
10	MP0005499_abnormal_olfactory_system	2.16667058
11	MP0005394_taste/olfaction_phenotype	2.16667058
12	MP0002653_abnormal_ependyma_morphology	2.14619114
13	MP0001984_abnormal_olfaction	2.14006403
14	MP0003635_abnormal_synaptic_transmissio	2.07782098
15	MP0002822_catalepsy	2.02146705
16	MP0008789_abnormal_olfactory_epithelium	1.99933302
17	MP0004133_heterotaxia	1.96511737
18	MP0005423_abnormal_somatic_nervous	1.89410911
19	MP0002063_abnormal_learning/memory/cond	1.77807264
20	MP0002734_abnormal_mechanical_nocicepti	1.68930083
21	MP0004142_abnormal_muscle_tone	1.68883764
22	MP0002735_abnormal_chemical_nociception	1.68791092
23	MP0003121_genomic_imprinting	1.68697800
24	MP0002572_abnormal_emotion/affect_behav	1.65691526
25	MP0000566_synostosis	1.65070433
26	MP0003136_yellow_coat_color	1.60430496
27	MP0002272_abnormal_nervous_system	1.60330781
28	MP0000631_abnormal_neuroendocrine_gland	1.58701596
29	MP0001486_abnormal_startle_reflex	1.57472384
30	MP0002102_abnormal_ear_morphology	1.56860340
31	MP0002557_abnormal_social/conspecific_i	1.56771520
32	MP0009745_abnormal_behavioral_response	1.56660755
33	MP0010030_abnormal_orbit_morphology	1.55575354
34	MP0000955_abnormal_spinal_cord	1.55505165
35	MP0002064_seizures	1.51012481
36	MP0004885_abnormal_endolymph	1.50686186
37	MP0002184_abnormal_innervation	1.49300858
38	MP0006072_abnormal_retinal_apoptosis	1.43623974
39	MP0004811_abnormal_neuron_physiology	1.43390202
40	MP0001502_abnormal_circadian_rhythm	1.41942029
41	MP0002882_abnormal_neuron_morphology	1.38247730
42	MP0009046_muscle_twitch	1.36837547
43	MP0001968_abnormal_touch/_nociception	1.36283550
44	MP0003861_abnormal_nervous_system	1.32252196
45	MP0002152_abnormal_brain_morphology	1.32131782
46	MP0002938_white_spotting	1.32030586
47	MP0000026_abnormal_inner_ear	1.31652679
48	MP0002736_abnormal_nociception_after	1.30187789
49	MP0001299_abnormal_eye_distance/	1.30057439
50	MP0003119_abnormal_digestive_system	1.29595295
51	MP0003937_abnormal_limbs/digits/tail_de	1.27550048
52	MP0005253_abnormal_eye_physiology	1.26085113
53	MP0003938_abnormal_ear_development	1.25610087
54	MP0001293_anophthalmia	1.24574772
55	MP0003755_abnormal_palate_morphology	1.24565916
56	MP0001970_abnormal_pain_threshold	1.24172633
57	MP0002751_abnormal_autonomic_nervous	1.23158655
58	MP0002733_abnormal_thermal_nociception	1.22778180
59	MP0002638_abnormal_pupillary_reflex	1.21135127
60	MP0002752_abnormal_somatic_nervous	1.21098963
61	MP0003942_abnormal_urinary_system	1.18674436
62	MP0001440_abnormal_grooming_behavior	1.18605200
63	MP0002233_abnormal_nose_morphology	1.18302239
64	MP0003283_abnormal_digestive_organ	1.18161312
65	MP0003890_abnormal_embryonic-extraembry	1.17482955
66	MP0003787_abnormal_imprinting	1.16695219
67	MP0002067_abnormal_sensory_capabilities	1.16304220
68	MP0002234_abnormal_pharynx_morphology	1.11780843
69	MP0003385_abnormal_body_wall	1.08833891
70	MP0005386_behavior/neurological_phenoty	1.07884380
71	MP0004924_abnormal_behavior	1.07884380
72	MP0001905_abnormal_dopamine_level	1.02036603
73	MP0002282_abnormal_trachea_morphology	1.01434466
74	MP0002116_abnormal_craniofacial_bone	0.99471319
75	MP0005551_abnormal_eye_electrophysiolog	0.99127989
76	MP0005391_vision/eye_phenotype	0.98543125
77	MP0001963_abnormal_hearing_physiology	0.94950698
78	MP0005195_abnormal_posterior_eye	0.94948655
79	MP0002697_abnormal_eye_size	0.94752441
80	MP0001188_hyperpigmentation	0.94526291
81	MP0003567_abnormal_fetal_cardiomyocyte	0.94352762
82	MP0001286_abnormal_eye_development	0.92569412
83	MP0002909_abnormal_adrenal_gland	0.91966447
84	MP0009250_abnormal_appendicular_skeleto	0.91492479
85	MP0002081_perinatal_lethality	0.91182925
86	MP0000534_abnormal_ureter_morphology	0.90682724
87	MP0005645_abnormal_hypothalamus_physiol	0.89861698
88	MP0002249_abnormal_larynx_morphology	0.89852526
89	MP0002066_abnormal_motor_capabilities/c	0.89595081
90	MP0005171_absent_coat_pigmentation	0.88102676
91	MP0003011_delayed_dark_adaptation	0.86602424
92	MP0001177_atelectasis	0.86093608
93	MP0005248_abnormal_Harderian_gland	0.85101196
94	MP0005187_abnormal_penis_morphology	0.84733515
95	MP0008877_abnormal_DNA_methylation	0.84488680
96	MP0004742_abnormal_vestibular_system	0.82760950
97	MP0005646_abnormal_pituitary_gland	0.82157163
98	MP0001485_abnormal_pinna_reflex	0.81571173
99	MP0003935_abnormal_craniofacial_develop	0.79936692
100	MP0000537_abnormal_urethra_morphology	0.78191385

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoplastic pelvis (HP:0008839)	3.40718088
2	Septo-optic dysplasia (HP:0100842)	3.07202768
3	Polyphagia (HP:0002591)	2.93567000
4	Gait imbalance (HP:0002141)	2.86580364
5	Cortical dysplasia (HP:0002539)	2.74790289
6	True hermaphroditism (HP:0010459)	2.70305911
7	Short 4th metacarpal (HP:0010044)	2.68717797
8	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.68717797
9	Drooling (HP:0002307)	2.64592635
10	Hypoplasia of the brainstem (HP:0002365)	2.61488276
11	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.61488276
12	Pancreatic fibrosis (HP:0100732)	2.61396214
13	Myokymia (HP:0002411)	2.57909609
14	Lissencephaly (HP:0001339)	2.53621865
15	Congenital primary aphakia (HP:0007707)	2.50240481
16	Vaginal atresia (HP:0000148)	2.47589947
17	Pancreatic cysts (HP:0001737)	2.45639413
18	Medial flaring of the eyebrow (HP:0010747)	2.45218848
19	Genital tract atresia (HP:0001827)	2.44194960
20	Retinal dysplasia (HP:0007973)	2.37563883
21	Nephrogenic diabetes insipidus (HP:0009806)	2.35769831
22	Excessive salivation (HP:0003781)	2.34270932
23	Myelomeningocele (HP:0002475)	2.34267122
24	Abnormality of the 4th metacarpal (HP:0010012)	2.30652396
25	Specific learning disability (HP:0001328)	2.29455788
26	Pachygyria (HP:0001302)	2.29366196
27	Optic nerve hypoplasia (HP:0000609)	2.26084402
28	Abnormality of the labia minora (HP:0012880)	2.25634511
29	Humeroradial synostosis (HP:0003041)	2.21120295
30	Synostosis involving the elbow (HP:0003938)	2.21120295
31	Hepatoblastoma (HP:0002884)	2.19721109
32	Progressive cerebellar ataxia (HP:0002073)	2.19291150
33	Fibular aplasia (HP:0002990)	2.18869338
34	Meningocele (HP:0002435)	2.18105522
35	Anomalous pulmonary venous return (HP:0010772)	2.15074870
36	Limb dystonia (HP:0002451)	2.13594349
37	Type II lissencephaly (HP:0007260)	2.13052460
38	Amblyopia (HP:0000646)	2.12243157
39	Anophthalmia (HP:0000528)	2.11017649
40	Occipital encephalocele (HP:0002085)	2.10645223
41	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.09917915
42	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.09241651
43	Morphological abnormality of the middle ear (HP:0008609)	2.07853556
44	Abnormality of midbrain morphology (HP:0002418)	2.07510270
45	Molar tooth sign on MRI (HP:0002419)	2.07510270
46	Focal motor seizures (HP:0011153)	2.06599773
47	Split foot (HP:0001839)	2.06403399
48	Postaxial hand polydactyly (HP:0001162)	2.05974680
49	Pendular nystagmus (HP:0012043)	2.04776465
50	Focal seizures (HP:0007359)	2.04027930
51	Vitreoretinal degeneration (HP:0000655)	2.02759559
52	Short tibia (HP:0005736)	2.02113862
53	Hemiparesis (HP:0001269)	2.01136942
54	Abnormality of the corticospinal tract (HP:0002492)	1.98494982
55	Nephronophthisis (HP:0000090)	1.98482879
56	Genetic anticipation (HP:0003743)	1.97910413
57	Abnormal eating behavior (HP:0100738)	1.96831230
58	Abnormality of the middle phalanges of the toes (HP:0010183)	1.96459774
59	Broad foot (HP:0001769)	1.94963302
60	Aplasia of the phalanges of the hand (HP:0009802)	1.94686651
61	Aplasia involving bones of the extremities (HP:0009825)	1.94686651
62	Aplasia involving bones of the upper limbs (HP:0009823)	1.94686651
63	Increased corneal curvature (HP:0100692)	1.93429568
64	Keratoconus (HP:0000563)	1.93429568
65	Oligodactyly (hands) (HP:0001180)	1.92800588
66	Failure to thrive in infancy (HP:0001531)	1.91599090
67	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.90795794
68	Esotropia (HP:0000565)	1.89193344
69	Abnormality of the pulmonary veins (HP:0011718)	1.88407142
70	Intestinal atresia (HP:0011100)	1.87905631
71	Chronic hepatic failure (HP:0100626)	1.87414447
72	Abnormality of the intervertebral disk (HP:0005108)	1.85873177
73	Sleep apnea (HP:0010535)	1.85664807
74	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.85197501
75	Hyperventilation (HP:0002883)	1.84748876
76	Impaired vibration sensation in the lower limbs (HP:0002166)	1.83745773
77	Anencephaly (HP:0002323)	1.82459120
78	Hemivertebrae (HP:0002937)	1.81493605
79	Cutaneous finger syndactyly (HP:0010554)	1.81429688
80	Fibular hypoplasia (HP:0003038)	1.80036313
81	Cerebellar dysplasia (HP:0007033)	1.79404168
82	Abnormality of the aortic arch (HP:0012303)	1.79048663
83	Agitation (HP:0000713)	1.77833387
84	Oligodactyly (HP:0012165)	1.77425602
85	Sclerocornea (HP:0000647)	1.77406161
86	Hypoplasia of the corpus callosum (HP:0002079)	1.77377740
87	Absent septum pellucidum (HP:0001331)	1.77155740
88	Poor coordination (HP:0002370)	1.76317932
89	Action tremor (HP:0002345)	1.76238352
90	Cystic liver disease (HP:0006706)	1.75236902
91	Urinary urgency (HP:0000012)	1.74960376
92	Megalencephaly (HP:0001355)	1.73591731
93	Spastic gait (HP:0002064)	1.73224038
94	Hypoventilation (HP:0002791)	1.72762473
95	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.72619568
96	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.72576352
97	Abnormality of the metopic suture (HP:0005556)	1.72280375
98	Postaxial foot polydactyly (HP:0001830)	1.72098575
99	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.71659259
100	Morphological abnormality of the pyramidal tract (HP:0002062)	1.71363039

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	4.75541965
2	CASK	3.59033594
3	MAP3K4	3.52333665
4	MAP2K7	3.30618338
5	BCR	2.77979518
6	DYRK2	2.61250695
7	NTRK2	2.40539270
8	MAP4K2	2.39828718
9	WNK3	2.37441221
10	EPHA4	2.11343372
11	CSNK1G2	2.04779878
12	EPHA3	2.02229643
13	CSNK1G3	1.92263507
14	CDK19	1.89075868
15	MAPK13	1.88243365
16	EPHB2	1.88114497
17	CSNK1A1L	1.87993718
18	TRIM28	1.83214914
19	TNIK	1.73048726
20	CSNK1G1	1.58243936
21	MAP2K4	1.58203403
22	SIK2	1.57177357
23	DYRK3	1.53866221
24	DYRK1B	1.29585226
25	PINK1	1.26966953
26	BCKDK	1.22880155
27	NTRK1	1.19795944
28	PAK6	1.19711816
29	SGK494	1.18616327
30	SGK223	1.18616327
31	LIMK1	1.15484205
32	ERBB3	1.13943499
33	UHMK1	1.12425919
34	PRKCG	1.11015682
35	SRPK1	1.06157245
36	DYRK1A	1.05828474
37	MINK1	1.02989984
38	PLK2	1.02744725
39	PAK3	1.01983616
40	NTRK3	1.00837084
41	TYRO3	1.00593164
42	FGFR2	0.93334639
43	CDK5	0.92320219
44	MAPK15	0.88435481
45	PRKD3	0.88146988
46	GRK7	0.85494975
47	PKN1	0.83943503
48	DDR2	0.82425469
49	PRKCE	0.81412922
50	RPS6KA4	0.80197346
51	CDK14	0.77630651
52	WNK1	0.75285369
53	CDK18	0.72723787
54	CDK11A	0.71392842
55	SGK2	0.70833624
56	PHKG1	0.70429530
57	PHKG2	0.70429530
58	CDK15	0.70204051
59	PRKD2	0.67954105
60	DAPK2	0.65625194
61	ADRBK2	0.65248290
62	CAMK2B	0.64992709
63	GRK1	0.59734362
64	CAMK2A	0.59572796
65	MKNK1	0.56078079
66	MARK2	0.55242281
67	ERBB2	0.54625845
68	KSR1	0.54361489
69	BMPR1B	0.53242957
70	WNK4	0.52953046
71	PRKAA1	0.52041639
72	PRKCZ	0.51254265
73	PNCK	0.51207266
74	CSNK1D	0.51076280
75	BRD4	0.50739760
76	RPS6KA2	0.50189330
77	ADRBK1	0.47994949
78	CSNK1A1	0.47790842
79	STK38L	0.46998268
80	EPHB1	0.46348936
81	ICK	0.45559861
82	AURKA	0.40453762
83	CAMK4	0.39794557
84	INSRR	0.39158035
85	PRKACA	0.38576768
86	CAMK2G	0.38401773
87	TESK1	0.38134376
88	NEK9	0.37352269
89	STK16	0.36862663
90	MAPK9	0.36769908
91	FGFR1	0.35932542
92	CSNK1E	0.35852760
93	RPS6KA5	0.34690663
94	PIM2	0.34050382
95	CAMK2D	0.31019886
96	MAP3K5	0.30779884
97	MAP3K6	0.29534470
98	VRK1	0.29475930
99	MAPKAPK5	0.29326912
100	PRKACB	0.28570190

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.61235217
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.08513638
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.51952193
4	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	2.44725274
5	GABAergic synapse_Homo sapiens_hsa04727	2.40289391
6	Axon guidance_Homo sapiens_hsa04360	2.15761997
7	Steroid biosynthesis_Homo sapiens_hsa00100	2.11371767
8	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.06511191
9	Basal cell carcinoma_Homo sapiens_hsa05217	2.04468418
10	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.03351742
11	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.94063652
12	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.93344047
13	Morphine addiction_Homo sapiens_hsa05032	1.93308513
14	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.92148312
15	Glutamatergic synapse_Homo sapiens_hsa04724	1.86107579
16	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.85158615
17	Cocaine addiction_Homo sapiens_hsa05030	1.79593412
18	Circadian entrainment_Homo sapiens_hsa04713	1.63487180
19	Hippo signaling pathway_Homo sapiens_hsa04390	1.62296724
20	Dopaminergic synapse_Homo sapiens_hsa04728	1.59178153
21	Butanoate metabolism_Homo sapiens_hsa00650	1.53210523
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.47048807
23	Oxidative phosphorylation_Homo sapiens_hsa00190	1.45747087
24	Taste transduction_Homo sapiens_hsa04742	1.43069699
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.42682564
26	Phototransduction_Homo sapiens_hsa04744	1.39339169
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.32777532
28	Parkinsons disease_Homo sapiens_hsa05012	1.31788335
29	Gap junction_Homo sapiens_hsa04540	1.30187095
30	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.28287047
31	Insulin secretion_Homo sapiens_hsa04911	1.25929724
32	Protein export_Homo sapiens_hsa03060	1.19628824
33	Wnt signaling pathway_Homo sapiens_hsa04310	1.10868538
34	Cholinergic synapse_Homo sapiens_hsa04725	1.10136395
35	Alcoholism_Homo sapiens_hsa05034	1.09584325
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.08815647
37	Amphetamine addiction_Homo sapiens_hsa05031	1.06795107
38	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.06750528
39	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.06411348
40	Melanogenesis_Homo sapiens_hsa04916	1.03237474
41	Huntingtons disease_Homo sapiens_hsa05016	1.00153968
42	Alzheimers disease_Homo sapiens_hsa05010	0.96880196
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.87835727
44	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.85426993
45	Gastric acid secretion_Homo sapiens_hsa04971	0.83247070
46	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.82022985
47	Serotonergic synapse_Homo sapiens_hsa04726	0.80362167
48	Vibrio cholerae infection_Homo sapiens_hsa05110	0.78197516
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.74179686
50	Sulfur relay system_Homo sapiens_hsa04122	0.71533150
51	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.70925598
52	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.70805389
53	Propanoate metabolism_Homo sapiens_hsa00640	0.70558356
54	Long-term depression_Homo sapiens_hsa04730	0.69647094
55	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.68567903
56	cAMP signaling pathway_Homo sapiens_hsa04024	0.66916658
57	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.65950614
58	Olfactory transduction_Homo sapiens_hsa04740	0.65705928
59	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.65396576
60	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.63816300
61	Ether lipid metabolism_Homo sapiens_hsa00565	0.63418549
62	Peroxisome_Homo sapiens_hsa04146	0.63175565
63	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.62320974
64	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.60542575
65	Salivary secretion_Homo sapiens_hsa04970	0.59711950
66	Rap1 signaling pathway_Homo sapiens_hsa04015	0.58092955
67	Basal transcription factors_Homo sapiens_hsa03022	0.57541286
68	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.56461585
69	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.56314001
70	Circadian rhythm_Homo sapiens_hsa04710	0.55377489
71	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.54630930
72	Ras signaling pathway_Homo sapiens_hsa04014	0.54529840
73	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.53371014
74	Oocyte meiosis_Homo sapiens_hsa04114	0.52335225
75	Melanoma_Homo sapiens_hsa05218	0.52201454
76	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.51293459
77	Notch signaling pathway_Homo sapiens_hsa04330	0.51144128
78	Protein digestion and absorption_Homo sapiens_hsa04974	0.50617155
79	Fatty acid metabolism_Homo sapiens_hsa01212	0.50163959
80	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.48904089
81	Selenocompound metabolism_Homo sapiens_hsa00450	0.48250106
82	Spliceosome_Homo sapiens_hsa03040	0.47584701
83	Calcium signaling pathway_Homo sapiens_hsa04020	0.47073138
84	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.46917211
85	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.46500943
86	Tight junction_Homo sapiens_hsa04530	0.45971649
87	Regulation of autophagy_Homo sapiens_hsa04140	0.45893247
88	Renin secretion_Homo sapiens_hsa04924	0.45020851
89	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.43688729
90	Adherens junction_Homo sapiens_hsa04520	0.43196996
91	Fatty acid elongation_Homo sapiens_hsa00062	0.42778383
92	Fanconi anemia pathway_Homo sapiens_hsa03460	0.42759445
93	mRNA surveillance pathway_Homo sapiens_hsa03015	0.41755483
94	AMPK signaling pathway_Homo sapiens_hsa04152	0.40851416
95	RNA polymerase_Homo sapiens_hsa03020	0.39152282
96	Arginine and proline metabolism_Homo sapiens_hsa00330	0.37499894
97	ECM-receptor interaction_Homo sapiens_hsa04512	0.37214173
98	Type II diabetes mellitus_Homo sapiens_hsa04930	0.36817077
99	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.36303042
100	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.35432486

MAGED4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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