MAGED4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the MAGED gene family. It is expressed only in brain and ovary, and some transcript variants of this gene are specifically expressed in glioma cells. This gene is clustered with other MAGED genes on chromosome Xp11. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.00930394
2postsynaptic membrane organization (GO:0001941)5.45187842
3nucleobase catabolic process (GO:0046113)5.43785952
4presynaptic membrane assembly (GO:0097105)5.22641201
5neuron cell-cell adhesion (GO:0007158)4.94827540
6presynaptic membrane organization (GO:0097090)4.81315125
7establishment of mitochondrion localization (GO:0051654)4.44697221
8protein localization to synapse (GO:0035418)4.27140641
9axonal fasciculation (GO:0007413)4.26536982
10neuron recognition (GO:0008038)4.14111512
11cell migration in hindbrain (GO:0021535)3.99845058
12vocalization behavior (GO:0071625)3.94473017
13neurotransmitter-gated ion channel clustering (GO:0072578)3.84850354
14gamma-aminobutyric acid transport (GO:0015812)3.66663892
15regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.54949560
16positive regulation of synapse assembly (GO:0051965)3.53101345
17synapse assembly (GO:0007416)3.52461152
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.50404142
19calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.47883315
20dendritic spine morphogenesis (GO:0060997)3.47860319
21auditory behavior (GO:0031223)3.47593857
22negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.31800930
23establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.27831058
24mitochondrion transport along microtubule (GO:0047497)3.27831058
25regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.23405850
26synaptic vesicle maturation (GO:0016188)3.19700597
27retinal ganglion cell axon guidance (GO:0031290)3.16768342
28layer formation in cerebral cortex (GO:0021819)3.16445683
29regulation of synapse structural plasticity (GO:0051823)3.16352207
30behavioral response to nicotine (GO:0035095)3.15305519
31regulation of short-term neuronal synaptic plasticity (GO:0048172)3.15267208
32nonmotile primary cilium assembly (GO:0035058)3.10879748
33cerebral cortex radially oriented cell migration (GO:0021799)3.09527825
34axon extension (GO:0048675)3.08063973
35ionotropic glutamate receptor signaling pathway (GO:0035235)3.07930371
36negative regulation of oligodendrocyte differentiation (GO:0048715)3.05472865
37positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.05101675
38negative regulation of synaptic transmission, GABAergic (GO:0032229)3.00777892
39spinal cord development (GO:0021510)2.99568230
40transmission of nerve impulse (GO:0019226)2.98033907
41positive regulation of mitochondrial fission (GO:0090141)2.96574223
42forebrain neuron differentiation (GO:0021879)2.96410517
43synaptic transmission, glutamatergic (GO:0035249)2.94293317
44sequestering of actin monomers (GO:0042989)2.94221792
45hippocampus development (GO:0021766)2.92928420
46response to auditory stimulus (GO:0010996)2.91703418
47dendrite morphogenesis (GO:0048813)2.91133187
48central nervous system projection neuron axonogenesis (GO:0021952)2.91067300
49olfactory bulb development (GO:0021772)2.88059458
50mechanosensory behavior (GO:0007638)2.87888664
51regulation of synaptic vesicle exocytosis (GO:2000300)2.85846682
52regulation of respiratory system process (GO:0044065)2.85181777
53limb bud formation (GO:0060174)2.83054073
54synapse organization (GO:0050808)2.80668973
55neuron projection extension involved in neuron projection guidance (GO:1902284)2.80185948
56axon extension involved in axon guidance (GO:0048846)2.80185948
57synaptic vesicle exocytosis (GO:0016079)2.78384068
58exploration behavior (GO:0035640)2.77445344
59glutamate secretion (GO:0014047)2.77206407
60locomotory exploration behavior (GO:0035641)2.77152067
61positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.77129403
62neuronal action potential propagation (GO:0019227)2.71996046
63neuronal ion channel clustering (GO:0045161)2.71525741
64regulation of synapse assembly (GO:0051963)2.70821304
65negative regulation of axon guidance (GO:1902668)2.63492428
66neurofilament cytoskeleton organization (GO:0060052)2.60354060
67neurotransmitter secretion (GO:0007269)2.58661245
68glutamate receptor signaling pathway (GO:0007215)2.58383045
69neuron projection extension (GO:1990138)2.57693188
70synaptic vesicle endocytosis (GO:0048488)2.57320824
71neuron migration (GO:0001764)2.54719994
72neuronal stem cell maintenance (GO:0097150)2.53053338
73negative regulation of glial cell differentiation (GO:0045686)2.52467694
74substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.51628130
75substrate-independent telencephalic tangential migration (GO:0021826)2.51628130
76neuromuscular synaptic transmission (GO:0007274)2.50979678
77regulation of glutamate receptor signaling pathway (GO:1900449)2.50387837
78short-term memory (GO:0007614)2.49241502
79positive regulation of dendritic spine morphogenesis (GO:0061003)2.47884019
80regulation of development, heterochronic (GO:0040034)2.46367094
81neuron-neuron synaptic transmission (GO:0007270)2.45861492
82regulation of synaptic transmission, glutamatergic (GO:0051966)2.44952414
83regulation of axon guidance (GO:1902667)2.44474093
84regulation of synaptic vesicle transport (GO:1902803)2.44124050
85negative regulation of axon extension (GO:0030517)2.43254160
86G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.38839816
87negative regulation of axonogenesis (GO:0050771)2.38619266
88positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.38608825
89dendrite development (GO:0016358)2.38116107
90head development (GO:0060322)2.37535835
91ephrin receptor signaling pathway (GO:0048013)2.37364822
92cerebral cortex cell migration (GO:0021795)2.36783395
93spinal cord association neuron differentiation (GO:0021527)2.35795794
94startle response (GO:0001964)2.35597076
95nervous system development (GO:0007399)2.35316012
96homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.35068172
97adult walking behavior (GO:0007628)2.34573188
98somite development (GO:0061053)2.34405357
99appendage development (GO:0048736)2.33606171
100limb development (GO:0060173)2.33606171

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.61874301
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.36786275
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.11653777
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.11380509
5GBX2_23144817_ChIP-Seq_PC3_Human2.74047726
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.71696893
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.63361850
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.57628975
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.49611905
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.42003243
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.29151019
12REST_21632747_ChIP-Seq_MESCs_Mouse2.25774225
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23017106
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.21082779
15ZNF274_21170338_ChIP-Seq_K562_Hela2.17736419
16IGF1R_20145208_ChIP-Seq_DFB_Human2.15716601
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.15399223
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.03404638
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02685805
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02685805
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.92887060
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.91459998
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.90315319
24RNF2_27304074_Chip-Seq_NSC_Mouse1.89962146
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89802001
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.88931644
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85185740
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.83394421
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.80294012
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80205688
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.71195304
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.69974956
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66061885
34TAF15_26573619_Chip-Seq_HEK293_Human1.65286523
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58361804
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56938241
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54659056
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.53671030
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.45319706
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41777158
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40654516
42RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.38787249
43OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.38243012
44P300_19829295_ChIP-Seq_ESCs_Human1.29117719
45SOX2_16153702_ChIP-ChIP_HESCs_Human1.26891151
46DROSHA_22980978_ChIP-Seq_HELA_Human1.24130315
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22612001
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20609894
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20600305
50FUS_26573619_Chip-Seq_HEK293_Human1.20274568
51FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15801383
52KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14619682
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.14456196
54RARB_27405468_Chip-Seq_BRAIN_Mouse1.13573864
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12690021
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12247881
57EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11213240
58RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.11186078
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.10056661
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09811976
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09811976
62TP53_20018659_ChIP-ChIP_R1E_Mouse1.08709189
63SMAD4_21799915_ChIP-Seq_A2780_Human1.08594632
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08222904
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06130534
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.05286918
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.05019107
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.03954225
69AR_21572438_ChIP-Seq_LNCaP_Human1.03478145
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03402500
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01304059
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01239630
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.01179023
74SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.00848407
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00714300
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00319207
77IRF1_19129219_ChIP-ChIP_H3396_Human1.00019713
78SOX9_26525672_Chip-Seq_HEART_Mouse0.98769216
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97734740
80POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.97603723
81STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97146293
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96834791
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96479975
84EWS_26573619_Chip-Seq_HEK293_Human0.96152465
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94777493
86TBX3_20139965_ChIP-Seq_MESCs_Mouse0.92320735
87SOX2_21211035_ChIP-Seq_LN229_Gbm0.91981279
88TBX3_20139965_ChIP-Seq_ESCs_Mouse0.91820643
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90559032
90AR_19668381_ChIP-Seq_PC3_Human0.90333746
91ISL1_27105846_Chip-Seq_CPCs_Mouse0.90123910
92TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90008253
93SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89416354
94CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89088342
95WT1_19549856_ChIP-ChIP_CCG9911_Human0.88340890
96EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87721513
97IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87187785
98VDR_22108803_ChIP-Seq_LS180_Human0.85386544
99AR_25329375_ChIP-Seq_VCAP_Human0.84971552
100SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83943512

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting3.47409917
2MP0004859_abnormal_synaptic_plasticity3.31863217
3MP0003880_abnormal_central_pattern3.10105168
4MP0000778_abnormal_nervous_system2.90190009
5MP0001529_abnormal_vocalization2.80479042
6MP0004270_analgesia2.66819776
7MP0006276_abnormal_autonomic_nervous2.25084057
8MP0005423_abnormal_somatic_nervous2.24510268
9MP0001984_abnormal_olfaction2.24333056
10MP0005394_taste/olfaction_phenotype2.18863542
11MP0005499_abnormal_olfactory_system2.18863542
12MP0003635_abnormal_synaptic_transmissio2.16696546
13MP0002822_catalepsy2.16430586
14MP0003121_genomic_imprinting2.14796579
15MP0006292_abnormal_olfactory_placode1.97813620
16MP0000566_synostosis1.96289407
17MP0002653_abnormal_ependyma_morphology1.95674970
18MP0008789_abnormal_olfactory_epithelium1.93539379
19MP0002063_abnormal_learning/memory/cond1.88023535
20MP0003787_abnormal_imprinting1.82583319
21MP0002734_abnormal_mechanical_nocicepti1.77609338
22MP0000049_abnormal_middle_ear1.75412725
23MP0002572_abnormal_emotion/affect_behav1.73598800
24MP0000955_abnormal_spinal_cord1.73014473
25MP0004133_heterotaxia1.72568377
26MP0001486_abnormal_startle_reflex1.66689702
27MP0002557_abnormal_social/conspecific_i1.64479876
28MP0009745_abnormal_behavioral_response1.63515882
29MP0002102_abnormal_ear_morphology1.59110734
30MP0002272_abnormal_nervous_system1.58855030
31MP0002735_abnormal_chemical_nociception1.58100320
32MP0002736_abnormal_nociception_after1.57989352
33MP0003136_yellow_coat_color1.57971358
34MP0002184_abnormal_innervation1.56512975
35MP0002064_seizures1.54524304
36MP0001968_abnormal_touch/_nociception1.52689411
37MP0004811_abnormal_neuron_physiology1.50679934
38MP0009046_muscle_twitch1.46340046
39MP0004142_abnormal_muscle_tone1.44198616
40MP0002882_abnormal_neuron_morphology1.42198465
41MP0002638_abnormal_pupillary_reflex1.41909744
42MP0003938_abnormal_ear_development1.38575509
43MP0000631_abnormal_neuroendocrine_gland1.33789034
44MP0003861_abnormal_nervous_system1.32248089
45MP0001299_abnormal_eye_distance/1.30911731
46MP0002152_abnormal_brain_morphology1.30891055
47MP0002733_abnormal_thermal_nociception1.28639287
48MP0003119_abnormal_digestive_system1.27870582
49MP0010030_abnormal_orbit_morphology1.26725178
50MP0004885_abnormal_endolymph1.26550360
51MP0001970_abnormal_pain_threshold1.26183624
52MP0002751_abnormal_autonomic_nervous1.25897550
53MP0001188_hyperpigmentation1.23285527
54MP0002067_abnormal_sensory_capabilities1.22656440
55MP0002752_abnormal_somatic_nervous1.22099642
56MP0002233_abnormal_nose_morphology1.19411277
57MP0001293_anophthalmia1.19395420
58MP0000026_abnormal_inner_ear1.18481794
59MP0002938_white_spotting1.17649655
60MP0003385_abnormal_body_wall1.14918808
61MP0003937_abnormal_limbs/digits/tail_de1.14241607
62MP0003890_abnormal_embryonic-extraembry1.12901562
63MP0004924_abnormal_behavior1.10393102
64MP0005386_behavior/neurological_phenoty1.10393102
65MP0001502_abnormal_circadian_rhythm1.08826442
66MP0003755_abnormal_palate_morphology1.07477788
67MP0005551_abnormal_eye_electrophysiolog1.06382807
68MP0002909_abnormal_adrenal_gland1.06240841
69MP0001905_abnormal_dopamine_level1.04554932
70MP0003283_abnormal_digestive_organ1.02819823
71MP0003942_abnormal_urinary_system1.02287972
72MP0005253_abnormal_eye_physiology1.00567431
73MP0006072_abnormal_retinal_apoptosis0.98976712
74MP0002234_abnormal_pharynx_morphology0.97482734
75MP0002697_abnormal_eye_size0.96497347
76MP0002066_abnormal_motor_capabilities/c0.96423490
77MP0005187_abnormal_penis_morphology0.95630697
78MP0005645_abnormal_hypothalamus_physiol0.95065477
79MP0001286_abnormal_eye_development0.94372334
80MP0002249_abnormal_larynx_morphology0.93487633
81MP0003329_amyloid_beta_deposits0.92962357
82MP0008877_abnormal_DNA_methylation0.89578847
83MP0004742_abnormal_vestibular_system0.89079438
84MP0001963_abnormal_hearing_physiology0.88594764
85MP0005195_abnormal_posterior_eye0.87622376
86MP0003123_paternal_imprinting0.87142765
87MP0005391_vision/eye_phenotype0.87067024
88MP0003011_delayed_dark_adaptation0.86506967
89MP0000534_abnormal_ureter_morphology0.84331775
90MP0001177_atelectasis0.83991177
91MP0002069_abnormal_eating/drinking_beha0.83281338
92MP0003567_abnormal_fetal_cardiomyocyte0.83057018
93MP0002081_perinatal_lethality0.82893836
94MP0001440_abnormal_grooming_behavior0.80633702
95MP0002116_abnormal_craniofacial_bone0.80137504
96MP0005646_abnormal_pituitary_gland0.78247481
97MP0005248_abnormal_Harderian_gland0.78202709
98MP0001485_abnormal_pinna_reflex0.77922723
99MP0009384_cardiac_valve_regurgitation0.75563760
100MP0005377_hearing/vestibular/ear_phenot0.74221510

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)3.57741518
2Cortical dysplasia (HP:0002539)3.52170342
3Polyphagia (HP:0002591)3.45497559
4Hepatoblastoma (HP:0002884)3.10016521
5Limb dystonia (HP:0002451)3.02580636
6Abnormality of the labia minora (HP:0012880)2.99464352
7Gait imbalance (HP:0002141)2.93916348
8Drooling (HP:0002307)2.84794132
9Lissencephaly (HP:0001339)2.79219652
10Retinal dysplasia (HP:0007973)2.75235091
11Septo-optic dysplasia (HP:0100842)2.63448114
12Split foot (HP:0001839)2.61367297
13Hypoplasia of the brainstem (HP:0002365)2.59140815
14Aplasia/Hypoplasia of the brainstem (HP:0007362)2.59140815
15Focal motor seizures (HP:0011153)2.53510871
16Excessive salivation (HP:0003781)2.53287160
17Medial flaring of the eyebrow (HP:0010747)2.49815702
18Congenital primary aphakia (HP:0007707)2.48255509
19Focal seizures (HP:0007359)2.43694836
20Pachygyria (HP:0001302)2.42122595
21Nephrogenic diabetes insipidus (HP:0009806)2.39627115
22Vaginal atresia (HP:0000148)2.35481147
23Vitreoretinal degeneration (HP:0000655)2.33405954
24Genital tract atresia (HP:0001827)2.32323519
25Abnormal eating behavior (HP:0100738)2.21565431
26Optic nerve hypoplasia (HP:0000609)2.21012671
27Specific learning disability (HP:0001328)2.19328448
28Amblyopia (HP:0000646)2.19136240
29Anophthalmia (HP:0000528)2.16905614
30Failure to thrive in infancy (HP:0001531)2.15381644
31Abnormality of the lower motor neuron (HP:0002366)2.13945079
32True hermaphroditism (HP:0010459)2.11082056
33Morphological abnormality of the middle ear (HP:0008609)2.07915924
34Hypsarrhythmia (HP:0002521)2.07009070
35Poor suck (HP:0002033)2.05182128
36Spastic tetraplegia (HP:0002510)2.01399118
37Humeroradial synostosis (HP:0003041)2.01392873
38Synostosis involving the elbow (HP:0003938)2.01392873
39Oligodactyly (hands) (HP:0001180)2.00507670
40Epileptic encephalopathy (HP:0200134)1.99841000
41EEG with generalized epileptiform discharges (HP:0011198)1.99208549
42Renal hypoplasia (HP:0000089)1.98862947
43Epileptiform EEG discharges (HP:0011182)1.98060925
44Hemiparesis (HP:0001269)1.98002650
45Atonic seizures (HP:0010819)1.97247252
46Nephronophthisis (HP:0000090)1.96258192
47Broad foot (HP:0001769)1.96012134
48Abnormality of midbrain morphology (HP:0002418)1.92986760
49Molar tooth sign on MRI (HP:0002419)1.92986760
50Postaxial hand polydactyly (HP:0001162)1.92060420
51Type II lissencephaly (HP:0007260)1.91037692
52Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87998519
53Cutaneous finger syndactyly (HP:0010554)1.87658827
54Spastic gait (HP:0002064)1.87596660
55Esotropia (HP:0000565)1.86947425
56Intestinal atresia (HP:0011100)1.86101350
57Megalencephaly (HP:0001355)1.85725511
58Abnormality of the corticospinal tract (HP:0002492)1.85536734
59Sleep apnea (HP:0010535)1.84844249
60Supernumerary spleens (HP:0009799)1.84698401
61Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84073842
62Amyotrophic lateral sclerosis (HP:0007354)1.83417452
63Pancreatic fibrosis (HP:0100732)1.83283259
64Progressive cerebellar ataxia (HP:0002073)1.83256980
65Agitation (HP:0000713)1.83199047
66Hyperglycinemia (HP:0002154)1.82396387
67Hypoplastic pelvis (HP:0008839)1.81721042
68Urinary urgency (HP:0000012)1.79106181
69Trigonocephaly (HP:0000243)1.78675451
70Narrow forehead (HP:0000341)1.77755115
71Oligodactyly (HP:0012165)1.77264019
72Cutaneous syndactyly (HP:0012725)1.76953502
73High anterior hairline (HP:0009890)1.76764362
74Poor coordination (HP:0002370)1.76704220
75Short 4th metacarpal (HP:0010044)1.76409579
76Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.76409579
77Micropenis (HP:0000054)1.75560686
78Broad-based gait (HP:0002136)1.73436258
79Hypoplasia of the corpus callosum (HP:0002079)1.71915114
80Rib fusion (HP:0000902)1.71864651
81Abnormality of the aortic arch (HP:0012303)1.71718261
82Hypoventilation (HP:0002791)1.71533058
83Hemivertebrae (HP:0002937)1.70610877
84Ankle clonus (HP:0011448)1.69975566
85Occipital encephalocele (HP:0002085)1.67405227
86Polymicrogyria (HP:0002126)1.67100657
87Abnormality of the 4th metacarpal (HP:0010012)1.66141005
88Anterior segment dysgenesis (HP:0007700)1.65721011
89Meningocele (HP:0002435)1.64807691
90Abnormality of the pubic bones (HP:0003172)1.64004910
91Aplasia/Hypoplasia of the sternum (HP:0006714)1.63379364
92Pancreatic cysts (HP:0001737)1.62842973
93Sclerocornea (HP:0000647)1.62623563
94Broad alveolar ridges (HP:0000187)1.62403935
95Decreased testicular size (HP:0008734)1.62295236
96Absent septum pellucidum (HP:0001331)1.61786630
97Generalized tonic-clonic seizures (HP:0002069)1.60404039
98Impaired vibration sensation in the lower limbs (HP:0002166)1.59925978
99Abnormality of dentin (HP:0010299)1.57699119
100Scrotal hypoplasia (HP:0000046)1.57479558

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.41412945
2CASK3.97195917
3MAP3K43.06280349
4MAP2K72.86043579
5BCR2.83505981
6DYRK22.78804219
7NTRK22.75814312
8WNK32.30359535
9EPHA42.24942939
10MAPK131.98883515
11TNIK1.86794784
12EPHB21.81303428
13CSNK1G21.78611320
14NTRK31.69049590
15EPHA31.68806676
16MAP4K21.66774158
17CSNK1G31.64257187
18SIK21.62703009
19MINK11.61890386
20PAK61.56242675
21CSNK1A1L1.53563610
22TRIM281.53295079
23UHMK11.47210959
24TYRO31.47131275
25MAP2K41.44298017
26NTRK11.40039221
27CSNK1G11.39563898
28DYRK1B1.33205935
29CDK191.31981711
30PRKCG1.29237324
31PINK11.29161042
32PRKD31.25218091
33PNCK1.21215239
34FGFR21.20485055
35PLK21.18331266
36DYRK31.16216021
37BCKDK1.15468041
38PAK31.14956999
39LIMK11.07959204
40DYRK1A1.06860354
41CDK51.05406229
42SRPK11.03253010
43ERBB30.93841403
44CDK140.91792502
45SGK2230.89668261
46SGK4940.89668261
47BMPR1B0.87711959
48CDK180.85711883
49CDK150.83161715
50CDK11A0.81145740
51PHKG20.78265261
52PHKG10.78265261
53PKN10.76954429
54KSR10.74199790
55TESK10.74146479
56WNK40.73419559
57PRKCE0.70472887
58DAPK20.70407622
59CAMK2A0.68618716
60MAP3K60.66370594
61PRKCZ0.62882723
62CAMK2B0.61863092
63MAPK150.60970969
64MKNK10.58000380
65ERBB20.56760090
66ADRBK20.55929057
67MKNK20.51663198
68STK160.51500524
69TSSK60.50569326
70CSNK1E0.49625555
71RPS6KA40.47392218
72INSRR0.46756107
73CSNK1D0.45690486
74CSNK1A10.44246695
75GRK10.44047096
76DDR20.43754196
77CAMKK10.43078197
78STK38L0.42762976
79PRKAA10.39248450
80CAMK10.37786723
81CAMK2G0.37769967
82MARK20.36511839
83PRKACA0.36332315
84FGFR10.35929522
85CAMK40.35466860
86PRKDC0.35229984
87SGK20.35108603
88CAMK1G0.34958461
89MAPK90.34570036
90PRKACB0.33075065
91PLK40.32807915
92EPHB10.32447650
93CDK30.32365868
94CAMK2D0.31728801
95RPS6KA20.31727378
96ROCK20.30569195
97PLK30.30124728
98PRKG10.29356535
99PDGFRA0.29179713
100STK110.27510418

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.63159489
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.92505940
3Steroid biosynthesis_Homo sapiens_hsa001002.46006170
4GABAergic synapse_Homo sapiens_hsa047272.39786980
5Axon guidance_Homo sapiens_hsa043602.12452390
6Synaptic vesicle cycle_Homo sapiens_hsa047212.08375123
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06276783
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.06062408
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.02064072
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99345828
11Cocaine addiction_Homo sapiens_hsa050301.97760314
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.94243320
13Glutamatergic synapse_Homo sapiens_hsa047241.86873958
14Morphine addiction_Homo sapiens_hsa050321.82461590
15Basal cell carcinoma_Homo sapiens_hsa052171.79017314
16Dopaminergic synapse_Homo sapiens_hsa047281.73383228
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.72735224
18Circadian entrainment_Homo sapiens_hsa047131.65602722
19Hedgehog signaling pathway_Homo sapiens_hsa043401.65459856
20Phototransduction_Homo sapiens_hsa047441.55231749
21Hippo signaling pathway_Homo sapiens_hsa043901.46864007
22Cardiac muscle contraction_Homo sapiens_hsa042601.46504947
23Protein export_Homo sapiens_hsa030601.46370941
24Oxidative phosphorylation_Homo sapiens_hsa001901.45907852
25Butanoate metabolism_Homo sapiens_hsa006501.44264815
26Parkinsons disease_Homo sapiens_hsa050121.39981855
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.32879023
28Amphetamine addiction_Homo sapiens_hsa050311.30732579
29Taste transduction_Homo sapiens_hsa047421.26515810
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19419900
31Insulin secretion_Homo sapiens_hsa049111.18292964
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16134295
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14487082
34Gap junction_Homo sapiens_hsa045401.14025774
35Vibrio cholerae infection_Homo sapiens_hsa051101.13346847
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04926733
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02046386
38Cholinergic synapse_Homo sapiens_hsa047251.00687662
39Wnt signaling pathway_Homo sapiens_hsa043100.98411369
40Collecting duct acid secretion_Homo sapiens_hsa049660.97008681
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95805647
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93750741
43Melanogenesis_Homo sapiens_hsa049160.93709577
44Huntingtons disease_Homo sapiens_hsa050160.92210199
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91646469
46Serotonergic synapse_Homo sapiens_hsa047260.91190078
47Long-term depression_Homo sapiens_hsa047300.90588022
48Alzheimers disease_Homo sapiens_hsa050100.89840285
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88083954
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83685251
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80132370
52Propanoate metabolism_Homo sapiens_hsa006400.72653302
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71866339
54cAMP signaling pathway_Homo sapiens_hsa040240.71727138
55Olfactory transduction_Homo sapiens_hsa047400.70435575
56Fatty acid metabolism_Homo sapiens_hsa012120.68332908
57Alcoholism_Homo sapiens_hsa050340.65562894
58Biosynthesis of amino acids_Homo sapiens_hsa012300.63476139
59Oocyte meiosis_Homo sapiens_hsa041140.63218276
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61498141
61Gastric acid secretion_Homo sapiens_hsa049710.61105794
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59262583
63Fatty acid elongation_Homo sapiens_hsa000620.59228417
64Tight junction_Homo sapiens_hsa045300.59228312
65Peroxisome_Homo sapiens_hsa041460.59100466
66Arginine and proline metabolism_Homo sapiens_hsa003300.58613833
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58557715
68Notch signaling pathway_Homo sapiens_hsa043300.58325088
69Oxytocin signaling pathway_Homo sapiens_hsa049210.56216600
70Dilated cardiomyopathy_Homo sapiens_hsa054140.55851747
71Sulfur relay system_Homo sapiens_hsa041220.55624725
72Basal transcription factors_Homo sapiens_hsa030220.54465631
73Ether lipid metabolism_Homo sapiens_hsa005650.54203032
74mRNA surveillance pathway_Homo sapiens_hsa030150.52485113
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51039996
76Regulation of autophagy_Homo sapiens_hsa041400.49500593
77Selenocompound metabolism_Homo sapiens_hsa004500.48781719
78beta-Alanine metabolism_Homo sapiens_hsa004100.48027642
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47987191
80AMPK signaling pathway_Homo sapiens_hsa041520.46808699
81Ras signaling pathway_Homo sapiens_hsa040140.46224146
82Salivary secretion_Homo sapiens_hsa049700.44464970
83Fat digestion and absorption_Homo sapiens_hsa049750.44358242
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43012730
85Rap1 signaling pathway_Homo sapiens_hsa040150.42430805
86Calcium signaling pathway_Homo sapiens_hsa040200.41055438
87Spliceosome_Homo sapiens_hsa030400.41017213
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40761528
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.38647826
90Fanconi anemia pathway_Homo sapiens_hsa034600.38398651
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.38059722
92Thyroid hormone synthesis_Homo sapiens_hsa049180.36847880
93Circadian rhythm_Homo sapiens_hsa047100.36434798
94Protein digestion and absorption_Homo sapiens_hsa049740.36142833
95RNA polymerase_Homo sapiens_hsa030200.35732497
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33549555
97Metabolic pathways_Homo sapiens_hsa011000.32026880
98Renin secretion_Homo sapiens_hsa049240.31504431
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31319245
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.30959672

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