MAGEE2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the E subfamily of MAGE (melanoma antigen-encoding gene) gene family. The gene is intronless and the encoded protein has two of the MAGE domains which are characteristic of MAGE family proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)7.87627513
2somite rostral/caudal axis specification (GO:0032525)5.92733631
3maintenance of protein location in nucleus (GO:0051457)5.77311295
4neurofilament cytoskeleton organization (GO:0060052)5.47270969
5regulation of mammary gland epithelial cell proliferation (GO:0033599)5.22416569
6proline transport (GO:0015824)5.07786553
7regulation of MHC class I biosynthetic process (GO:0045343)5.06852276
8regulation of response to osmotic stress (GO:0047484)5.03981372
9presynaptic membrane organization (GO:0097090)5.03881106
10negative regulation of epidermis development (GO:0045683)5.03638599
11presynaptic membrane assembly (GO:0097105)5.00817086
12regulation of cilium movement (GO:0003352)4.89894667
13phenol-containing compound catabolic process (GO:0019336)4.84504403
14glutamate receptor signaling pathway (GO:0007215)4.75576752
15serotonin metabolic process (GO:0042428)4.64281986
16response to dietary excess (GO:0002021)4.60842670
17negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.58047278
18histone H4-K12 acetylation (GO:0043983)4.55660337
19locomotory exploration behavior (GO:0035641)4.55370818
20negative regulation of telomerase activity (GO:0051974)4.54187200
21negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.53544088
22histone H4-K5 acetylation (GO:0043981)4.48384017
23histone H4-K8 acetylation (GO:0043982)4.48384017
24regulation of nuclear cell cycle DNA replication (GO:0033262)4.44299329
25gamma-aminobutyric acid signaling pathway (GO:0007214)4.38681685
26muscle organ morphogenesis (GO:0048644)4.33270349
27neuron-neuron synaptic transmission (GO:0007270)4.32988825
28regulation of telomere maintenance via telomerase (GO:0032210)4.30842482
29positive regulation of amino acid transport (GO:0051957)4.25613171
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.22747364
31transmission of nerve impulse (GO:0019226)4.17705832
32regulation of excitatory postsynaptic membrane potential (GO:0060079)4.17432862
33negative regulation of cell cycle G2/M phase transition (GO:1902750)4.11929849
34synaptic vesicle maturation (GO:0016188)4.11297548
35exploration behavior (GO:0035640)4.10351991
36regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.09705662
37quinone metabolic process (GO:1901661)4.09615007
38negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.08671398
39gamma-aminobutyric acid transport (GO:0015812)4.08191002
40primary amino compound metabolic process (GO:1901160)4.00588837
41postsynaptic membrane organization (GO:0001941)3.98917975
42startle response (GO:0001964)3.97416091
43negative regulation of telomere maintenance (GO:0032205)3.96841101
44rRNA transcription (GO:0009303)3.96383459
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.96032830
46synaptic vesicle docking involved in exocytosis (GO:0016081)3.94424080
47dopamine biosynthetic process (GO:0042416)3.94118169
48negative regulation of epidermal cell differentiation (GO:0045605)3.92298120
49cytidine deamination (GO:0009972)3.90037206
50cytidine metabolic process (GO:0046087)3.90037206
51cytidine catabolic process (GO:0006216)3.90037206
52pyrimidine nucleobase catabolic process (GO:0006208)3.89325521
53mitochondrion distribution (GO:0048311)3.88500357
54calcium-mediated signaling using intracellular calcium source (GO:0035584)3.86420233
55interferon-gamma production (GO:0032609)3.86113939
56protein localization to microtubule (GO:0035372)3.85702286
57tachykinin receptor signaling pathway (GO:0007217)3.85574022
58ventricular system development (GO:0021591)3.85496019
59neuron cell-cell adhesion (GO:0007158)3.85134086
60cellular potassium ion homeostasis (GO:0030007)3.84252199
61coenzyme catabolic process (GO:0009109)3.80567097
62negative regulation of microtubule polymerization (GO:0031115)3.80315211
63attachment of spindle microtubules to kinetochore (GO:0008608)3.77815771
64regulation of postsynaptic membrane potential (GO:0060078)3.75678138
65notochord development (GO:0030903)3.75147770
66neuron recognition (GO:0008038)3.71746576
67regulation of synaptic vesicle exocytosis (GO:2000300)3.70818675
68positive regulation of synaptic transmission, GABAergic (GO:0032230)3.69805559
69regulation of synapse structural plasticity (GO:0051823)3.69628115
70cochlea development (GO:0090102)3.69311439
71brain morphogenesis (GO:0048854)3.66433761
72serotonin receptor signaling pathway (GO:0007210)3.63242173
73primitive streak formation (GO:0090009)3.63223888
74cell fate commitment involved in formation of primary germ layer (GO:0060795)3.61952931
75regulation of synaptic vesicle transport (GO:1902803)3.58526577
76positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.58101662
77prepulse inhibition (GO:0060134)3.57708842
78axon cargo transport (GO:0008088)3.56588738
79protein polyglutamylation (GO:0018095)3.55396315
80synaptic vesicle endocytosis (GO:0048488)3.53003298
81mitotic sister chromatid segregation (GO:0000070)3.50638513
82regulation of short-term neuronal synaptic plasticity (GO:0048172)3.49073604
83sodium ion export (GO:0071436)3.45777971
84nucleoside transmembrane transport (GO:1901642)3.45542750
85protein localization to kinetochore (GO:0034501)3.45013328
86positive regulation of synapse assembly (GO:0051965)3.44652634
87regulation of synaptic transmission, glutamatergic (GO:0051966)3.44435273
88response to histamine (GO:0034776)3.43571292
89regulation of microtubule-based movement (GO:0060632)3.42948637
90dendritic spine morphogenesis (GO:0060997)3.42702411
91neurotransmitter secretion (GO:0007269)3.42507359
92axonal fasciculation (GO:0007413)3.41122770
93membrane hyperpolarization (GO:0060081)3.40310729
94microtubule severing (GO:0051013)3.39425731
95regulation of telomere maintenance (GO:0032204)3.39208553
96cullin deneddylation (GO:0010388)3.37410007
97layer formation in cerebral cortex (GO:0021819)3.36473982
98vocalization behavior (GO:0071625)3.35910708
99auditory behavior (GO:0031223)3.34004879
100central nervous system projection neuron axonogenesis (GO:0021952)3.31307933
101cellular sodium ion homeostasis (GO:0006883)3.30868979
102membrane depolarization (GO:0051899)3.29152918
103neuronal action potential propagation (GO:0019227)3.28770892
104branching involved in mammary gland duct morphogenesis (GO:0060444)3.26921189
105response to auditory stimulus (GO:0010996)3.25918071
106neurotransmitter transport (GO:0006836)3.25847181
107detection of temperature stimulus (GO:0016048)3.25085491
108establishment of mitochondrion localization (GO:0051654)3.24672744
109regulation of dendritic spine morphogenesis (GO:0061001)3.24442824
110neurotransmitter-gated ion channel clustering (GO:0072578)3.24191412
111regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.23939804
112membrane depolarization during action potential (GO:0086010)3.23104092
113positive regulation of dendritic spine morphogenesis (GO:0061003)3.22295991
114histone H4-K16 acetylation (GO:0043984)3.21988875
115positive regulation of DNA-dependent DNA replication (GO:2000105)3.20295356
116regulation of neurotransmitter secretion (GO:0046928)3.18951627
117protein localization to microtubule cytoskeleton (GO:0072698)3.18785724
118bone trabecula formation (GO:0060346)3.17664514
119nucleobase catabolic process (GO:0046113)3.17436546
120hormone catabolic process (GO:0042447)3.16000867
121short-term memory (GO:0007614)3.13788698
122DNA damage response, detection of DNA damage (GO:0042769)3.11113013
123regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.10451832
124rRNA methylation (GO:0031167)3.10308028
125cerebellar Purkinje cell layer development (GO:0021680)3.09033885
126protein localization to cilium (GO:0061512)3.08727701
127negative regulation of dendrite morphogenesis (GO:0050774)3.08490294
128cardiovascular system development (GO:0072358)3.07629689
129regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.05244947
130negative regulation of dendrite development (GO:2000171)3.03083512
131protein localization to synapse (GO:0035418)2.99316099
132negative regulation of systemic arterial blood pressure (GO:0003085)2.97988835
133regulation of pigment cell differentiation (GO:0050932)2.97973489
134G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.97893890
135regulation of calcium ion-dependent exocytosis (GO:0017158)2.96063355
136righting reflex (GO:0060013)2.94634834
137establishment of pigment granule localization (GO:0051905)2.92596234
138response to cocaine (GO:0042220)2.91671180
139icosanoid secretion (GO:0032309)2.91250496
140arachidonic acid secretion (GO:0050482)2.91250496
141positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.91213530
142C4-dicarboxylate transport (GO:0015740)2.90929923
143positive regulation of membrane potential (GO:0045838)2.90730212
144response to amphetamine (GO:0001975)2.90138433
145regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.90070758
146negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.89845227
147regulation of neurotransmitter transport (GO:0051588)2.89578135
148phosphorelay signal transduction system (GO:0000160)2.89474728
149protein localization to cytoskeleton (GO:0044380)2.89362887
150microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.89166744
151fear response (GO:0042596)2.88944656
152regulation of vesicle fusion (GO:0031338)2.88870059
153establishment of synaptic vesicle localization (GO:0097480)2.88776451
154protein deneddylation (GO:0000338)2.84209585
155transepithelial transport (GO:0070633)2.83830910
156negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.83262256
157pigment granule transport (GO:0051904)2.82067613
158nucleoside transport (GO:0015858)2.81894531
159positive regulation of digestive system process (GO:0060456)2.80862230
160establishment of melanosome localization (GO:0032401)2.76188496
161regulation of telomerase activity (GO:0051972)2.74982765
162sister chromatid segregation (GO:0000819)2.74261752
163phosphatidylinositol 3-kinase signaling (GO:0014065)2.71823345
164regulation of glutamate receptor signaling pathway (GO:1900449)2.71440825
165behavioral defense response (GO:0002209)2.71421237
166behavioral fear response (GO:0001662)2.71421237
167neurotransmitter uptake (GO:0001504)2.69993475
168positive regulation of neurological system process (GO:0031646)2.68088394
169head development (GO:0060322)2.67105951
170synaptic transmission, glutamatergic (GO:0035249)2.66451617
171melanosome transport (GO:0032402)2.64313056
172regulation of apoptotic process involved in morphogenesis (GO:1902337)2.64274374
173maintenance of protein localization in organelle (GO:0072595)2.64023064
174positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.62687958
175cerebellar granule cell differentiation (GO:0021707)2.61436574
176synaptic vesicle exocytosis (GO:0016079)2.61057786
177glutamate secretion (GO:0014047)2.60523871
178ionotropic glutamate receptor signaling pathway (GO:0035235)2.59388648
179positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.59047393
180pigment granule localization (GO:0051875)2.58776366
181negative regulation of smoothened signaling pathway (GO:0045879)2.57678545
182thyroid hormone generation (GO:0006590)2.56941295
183rRNA modification (GO:0000154)2.56848165
184polyketide metabolic process (GO:0030638)12.2798729
185doxorubicin metabolic process (GO:0044598)12.2798729
186daunorubicin metabolic process (GO:0044597)12.2798729

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.98315123
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.52113721
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.52113721
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.52113721
5EZH2_22144423_ChIP-Seq_EOC_Human3.86871915
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.48180478
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.94909689
8TAF15_26573619_Chip-Seq_HEK293_Human2.91882131
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.83500919
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.71696358
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.71496781
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.65281636
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.54729098
14SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.29851206
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26515900
16DROSHA_22980978_ChIP-Seq_HELA_Human2.22537202
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.20467355
18RNF2_27304074_Chip-Seq_NSC_Mouse2.19943891
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.19549626
20IRF1_19129219_ChIP-ChIP_H3396_Human2.18657945
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.09910564
22IGF1R_20145208_ChIP-Seq_DFB_Human2.09772860
23TCF3_18692474_ChIP-Seq_MESCs_Mouse1.96284930
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.96213875
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.96213875
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.92360734
27* SMAD4_21799915_ChIP-Seq_A2780_Human1.89530603
28REST_21632747_ChIP-Seq_MESCs_Mouse1.88650549
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.86908322
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85344679
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.84733008
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.84361404
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.78318677
34GBX2_23144817_ChIP-Seq_PC3_Human1.78231651
35NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.78065319
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76303980
37SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.76255764
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71845454
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70467205
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68341266
41P300_19829295_ChIP-Seq_ESCs_Human1.66681413
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61829296
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.60857026
44NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.60037495
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59893462
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58603359
47TCF3_18692474_ChIP-Seq_MEFs_Mouse1.57167261
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.55602728
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54943520
50* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.53817422
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52035766
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.51196563
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50832038
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.50281245
55ZNF274_21170338_ChIP-Seq_K562_Hela1.48192049
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.47337380
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45600243
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45455797
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.44963835
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.44950963
61NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.44672866
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.43045037
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42587957
64POU5F1_16518401_ChIP-PET_MESCs_Mouse1.41925447
65AR_25329375_ChIP-Seq_VCAP_Human1.41656578
66TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.41281164
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41115232
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.40085221
69SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.39434354
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38476438
71SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38210267
72FUS_26573619_Chip-Seq_HEK293_Human1.36290900
73EED_16625203_ChIP-ChIP_MESCs_Mouse1.36269464
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.33937320
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32384833
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31767220
77STAT3_23295773_ChIP-Seq_U87_Human1.29101607
78TCF4_23295773_ChIP-Seq_U87_Human1.28513842
79AR_21572438_ChIP-Seq_LNCaP_Human1.28487281
80VDR_22108803_ChIP-Seq_LS180_Human1.27713322
81ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25496380
82CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24921023
83MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24213812
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.23748707
85RARB_27405468_Chip-Seq_BRAIN_Mouse1.22349449
86SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21962265
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20895749
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20472390
89PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.20443369
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20035952
91TP53_20018659_ChIP-ChIP_R1E_Mouse1.19264551
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17468692
93EZH2_27294783_Chip-Seq_ESCs_Mouse1.16423515
94PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16411261
95CDX2_20551321_ChIP-Seq_CACO-2_Human1.15370379
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13820383
97SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13424338
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13116270
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12162223
100EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11919642
101BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11849440
102ER_23166858_ChIP-Seq_MCF-7_Human1.11796710
103LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11720074
104BCAT_22108803_ChIP-Seq_LS180_Human1.11282122
105RUNX2_22187159_ChIP-Seq_PCA_Human1.10784314
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.10386655
107STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10165118
108CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10149658
109NANOG_18555785_Chip-Seq_ESCs_Mouse1.09231470
110ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08987345
111NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08622037
112NANOG_16518401_ChIP-PET_MESCs_Mouse1.08170094
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07554491
114YY1_21170310_ChIP-Seq_MESCs_Mouse1.06946104
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06674771
116RING1B_27294783_Chip-Seq_ESCs_Mouse1.06423593
117JUN_21703547_ChIP-Seq_K562_Human1.05309656
118YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04518076
119SOX2_16153702_ChIP-ChIP_HESCs_Human1.04256424
120STAT3_18555785_ChIP-Seq_MESCs_Mouse1.03986859
121SALL1_21062744_ChIP-ChIP_HESCs_Human1.03596692
122CBP_20019798_ChIP-Seq_JUKART_Human1.02570073
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02570073
124EP300_21415370_ChIP-Seq_HL-1_Mouse1.02343403
125TAL1_26923725_Chip-Seq_HPCs_Mouse1.01781908
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01630465
127TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01587819
128TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00985438
129NANOG_18692474_ChIP-Seq_MESCs_Mouse1.00732009
130NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00364574
131ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99619524
132ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99003730
133TP53_18474530_ChIP-ChIP_U2OS_Human0.98859830
134RXR_22108803_ChIP-Seq_LS180_Human0.97001115
135KDM2B_26808549_Chip-Seq_REH_Human0.96810696
136FLI1_27457419_Chip-Seq_LIVER_Mouse0.96775712
137POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95867210
138TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95867210
139P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95718277
140CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92077147
141POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91754818
142NANOG_16153702_ChIP-ChIP_HESCs_Human0.89023061
143STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88992418
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87147624
145CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87102285
146SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85813418
147RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85295291
148POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.84721563
149NANOG_18692474_ChIP-Seq_MEFs_Mouse0.84632887
150MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81030334
151WT1_19549856_ChIP-ChIP_CCG9911_Human0.79365730
152SMAD3_21741376_ChIP-Seq_HESCs_Human0.78928505
153TOP2B_26459242_ChIP-Seq_MCF-7_Human0.78061363
154KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.77020708

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.84377570
2MP0006292_abnormal_olfactory_placode4.42186287
3MP0010386_abnormal_urinary_bladder3.47537945
4MP0005394_taste/olfaction_phenotype3.34895216
5MP0005499_abnormal_olfactory_system3.34895216
6MP0004858_abnormal_nervous_system3.24618649
7MP0004264_abnormal_extraembryonic_tissu3.08782218
8MP0004742_abnormal_vestibular_system2.99597531
9MP0003121_genomic_imprinting2.93405828
10MP0003011_delayed_dark_adaptation2.91942788
11MP0003890_abnormal_embryonic-extraembry2.88386037
12MP0002254_reproductive_system_inflammat2.70041332
13MP0003880_abnormal_central_pattern2.55054670
14MP0003787_abnormal_imprinting2.51564016
15MP0000537_abnormal_urethra_morphology2.44386078
16MP0002332_abnormal_exercise_endurance2.40173698
17MP0009046_muscle_twitch2.27576684
18MP0004859_abnormal_synaptic_plasticity2.26243953
19MP0005075_abnormal_melanosome_morpholog2.25115568
20MP0003183_abnormal_peptide_metabolism2.19083328
21MP0008569_lethality_at_weaning2.16782477
22MP0002822_catalepsy2.15383380
23MP0002572_abnormal_emotion/affect_behav2.12808751
24MP0006276_abnormal_autonomic_nervous2.06656645
25MP0003938_abnormal_ear_development2.04735090
26MP0003635_abnormal_synaptic_transmissio2.03834512
27MP0000678_abnormal_parathyroid_gland2.03523011
28MP0006035_abnormal_mitochondrial_morpho2.02157584
29MP0001486_abnormal_startle_reflex1.99167071
30MP0002277_abnormal_respiratory_mucosa1.90017107
31MP0004885_abnormal_endolymph1.89620686
32MP0004270_analgesia1.88365228
33MP0002063_abnormal_learning/memory/cond1.80309263
34MP0002064_seizures1.75553967
35MP0005257_abnormal_intraocular_pressure1.70588296
36MP0008057_abnormal_DNA_replication1.65490590
37MP0009745_abnormal_behavioral_response1.60475677
38MP0002734_abnormal_mechanical_nocicepti1.58349920
39MP0003123_paternal_imprinting1.54925713
40MP0002638_abnormal_pupillary_reflex1.52406591
41MP0002733_abnormal_thermal_nociception1.52130378
42MP0008789_abnormal_olfactory_epithelium1.49175786
43MP0002184_abnormal_innervation1.48299292
44MP0004142_abnormal_muscle_tone1.47681481
45MP0001905_abnormal_dopamine_level1.47433488
46MP0001501_abnormal_sleep_pattern1.43177705
47MP0005423_abnormal_somatic_nervous1.41618183
48MP0002272_abnormal_nervous_system1.41465822
49MP0002653_abnormal_ependyma_morphology1.40640424
50MP0000778_abnormal_nervous_system1.40075163
51MP0003633_abnormal_nervous_system1.35883088
52MP0003329_amyloid_beta_deposits1.33582161
53MP0001968_abnormal_touch/_nociception1.26447661
54MP0002127_abnormal_cardiovascular_syste1.26421891
55MP0000049_abnormal_middle_ear1.25296881
56MP0000762_abnormal_tongue_morphology1.24720279
57MP0003879_abnormal_hair_cell1.23113562
58MP0003631_nervous_system_phenotype1.22359561
59MP0001440_abnormal_grooming_behavior1.21115217
60MP0002233_abnormal_nose_morphology1.20551589
61MP0008775_abnormal_heart_ventricle1.20105909
62MP0003137_abnormal_impulse_conducting1.20105202
63MP0001970_abnormal_pain_threshold1.19563871
64MP0008961_abnormal_basal_metabolism1.19247857
65MP0001177_atelectasis1.16903951
66MP0004215_abnormal_myocardial_fiber1.13706617
67MP0002751_abnormal_autonomic_nervous1.13045107
68MP0000631_abnormal_neuroendocrine_gland1.12647414
69MP0001502_abnormal_circadian_rhythm1.11935068
70MP0000955_abnormal_spinal_cord1.11629383
71MP0000920_abnormal_myelination1.11547674
72MP0002735_abnormal_chemical_nociception1.11280057
73MP0002229_neurodegeneration1.11095014
74MP0000538_abnormal_urinary_bladder1.09370498
75MP0002932_abnormal_joint_morphology1.06431938
76MP0002557_abnormal_social/conspecific_i1.06048297
77MP0001529_abnormal_vocalization1.05506303
78MP0001188_hyperpigmentation1.05351209
79MP0002067_abnormal_sensory_capabilities1.04558800
80MP0003632_abnormal_nervous_system1.02510288
81MP0001984_abnormal_olfaction1.02052721
82MP0002752_abnormal_somatic_nervous1.00507529
83MP0009384_cardiac_valve_regurgitation0.99195466
84MP0004147_increased_porphyrin_level0.98722456
85MP0005645_abnormal_hypothalamus_physiol0.98549330
86MP0002114_abnormal_axial_skeleton0.95124210
87MP0002882_abnormal_neuron_morphology0.92128539
88MP0002909_abnormal_adrenal_gland0.91678109
89MP0001293_anophthalmia0.90365368
90MP0004043_abnormal_pH_regulation0.90246312
91MP0003755_abnormal_palate_morphology0.90222254
92MP0006082_CNS_inflammation0.89369388
93MP0002163_abnormal_gland_morphology0.89212525
94MP0005386_behavior/neurological_phenoty0.87702725
95MP0004924_abnormal_behavior0.87702725
96MP0008872_abnormal_physiological_respon0.83864185
97MP0000569_abnormal_digit_pigmentation0.83648245
98MP0001963_abnormal_hearing_physiology0.82899493
99MP0005248_abnormal_Harderian_gland0.82147846
100MP0003119_abnormal_digestive_system0.81754031
101MP0002736_abnormal_nociception_after0.81646036
102MP0000566_synostosis0.81536329
103MP0005646_abnormal_pituitary_gland0.81389240
104MP0004133_heterotaxia0.81062635
105MP0001348_abnormal_lacrimal_gland0.80779541
106MP0005623_abnormal_meninges_morphology0.80728115
107MP0004085_abnormal_heartbeat0.80502015
108MP0005253_abnormal_eye_physiology0.80248904
109MP0003634_abnormal_glial_cell0.78622817
110MP0010030_abnormal_orbit_morphology0.78287701
111MP0004811_abnormal_neuron_physiology0.77732481
112MP0004957_abnormal_blastocyst_morpholog0.77352008
113MP0005535_abnormal_body_temperature0.76447923
114MP0008770_decreased_survivor_rate0.76023295
115MP0005187_abnormal_penis_morphology0.75940424
116MP0002234_abnormal_pharynx_morphology0.75827139
117MP0003861_abnormal_nervous_system0.75439035
118MP0008874_decreased_physiological_sensi0.74907536
119MP0000026_abnormal_inner_ear0.74889486
120MP0002066_abnormal_motor_capabilities/c0.72680300
121MP0000534_abnormal_ureter_morphology0.69725524
122MP0002116_abnormal_craniofacial_bone0.69159510
123MP0006072_abnormal_retinal_apoptosis0.68595142
124MP0003315_abnormal_perineum_morphology0.68471770
125MP0002081_perinatal_lethality0.68219374
126MP0005391_vision/eye_phenotype0.68029182
127MP0001672_abnormal_embryogenesis/_devel0.66742855
128MP0005380_embryogenesis_phenotype0.66742855
129MP0000751_myopathy0.66247401
130MP0005551_abnormal_eye_electrophysiolog0.66166938
131MP0002152_abnormal_brain_morphology0.65954930
132MP0001485_abnormal_pinna_reflex0.62471171
133MP0000579_abnormal_nail_morphology0.60532040
134MP0010770_preweaning_lethality0.59046713
135MP0002082_postnatal_lethality0.59046713
136MP0003690_abnormal_glial_cell0.57808117
137MP0010769_abnormal_survival0.57603399
138MP0010768_mortality/aging0.56185577
139MP0001943_abnormal_respiration0.56096003
140MP0002069_abnormal_eating/drinking_beha0.54383702
141MP0003956_abnormal_body_size0.50428910
142MP0004084_abnormal_cardiac_muscle0.46635270
143MP0005409_darkened_coat_color0.45550451
144MP0008877_abnormal_DNA_methylation0.44943884

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.12327278
2Hypochromic microcytic anemia (HP:0004840)5.06604528
3Hepatoblastoma (HP:0002884)5.05497253
4Action tremor (HP:0002345)5.02972453
5Abnormality of the lower motor neuron (HP:0002366)4.79490808
6Hyperventilation (HP:0002883)4.40647006
7Diplopia (HP:0000651)4.24518864
8Abnormality of binocular vision (HP:0011514)4.24518864
9Rib fusion (HP:0000902)4.01107313
10Bifid tongue (HP:0010297)3.67209142
11Neurofibrillary tangles (HP:0002185)3.60672574
12Amyotrophic lateral sclerosis (HP:0007354)3.57621245
13Febrile seizures (HP:0002373)3.57168551
14Nephroblastoma (Wilms tumor) (HP:0002667)3.53246585
15Partial duplication of thumb phalanx (HP:0009944)3.41963391
16Ulnar claw (HP:0001178)3.40509758
17Anomalous pulmonary venous return (HP:0010772)3.38406598
18Aplasia/Hypoplasia of the fovea (HP:0008060)3.36610585
19Hypoplasia of the fovea (HP:0007750)3.36610585
20Horizontal nystagmus (HP:0000666)3.32569026
21Sensory axonal neuropathy (HP:0003390)3.32329116
22Embryonal renal neoplasm (HP:0011794)3.30436866
23Progressive cerebellar ataxia (HP:0002073)3.29039511
24Epileptic encephalopathy (HP:0200134)3.28177273
25Degeneration of the lateral corticospinal tracts (HP:0002314)3.17806643
26Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.17806643
27Rectal fistula (HP:0100590)3.10736116
28Rectovaginal fistula (HP:0000143)3.10736116
29Amblyopia (HP:0000646)3.09712233
30Ankle clonus (HP:0011448)3.06204822
31Chromosomal breakage induced by crosslinking agents (HP:0003221)3.03498561
32Mutism (HP:0002300)3.01890885
33Neoplasm of striated muscle (HP:0009728)2.98295214
34Multiple enchondromatosis (HP:0005701)2.97753154
35Partial duplication of the phalanx of hand (HP:0009999)2.96026226
36Supranuclear gaze palsy (HP:0000605)2.95191059
37Abnormality of the pulmonary veins (HP:0011718)2.93052599
38Spastic tetraparesis (HP:0001285)2.89571149
39Ependymoma (HP:0002888)2.85570955
40Generalized hypotonia (HP:0001290)2.81966302
41Epileptiform EEG discharges (HP:0011182)2.81717920
42Progressive inability to walk (HP:0002505)2.81190473
43Testicular atrophy (HP:0000029)2.79162375
44Esophageal atresia (HP:0002032)2.73230602
45Status epilepticus (HP:0002133)2.72573872
46Abnormal eating behavior (HP:0100738)2.72151378
47Rhabdomyosarcoma (HP:0002859)2.66910204
48Intestinal fistula (HP:0100819)2.66861601
49Fused cervical vertebrae (HP:0002949)2.64025699
50Nasolacrimal duct obstruction (HP:0000579)2.63799200
51Broad-based gait (HP:0002136)2.59972788
52Aplasia/Hypoplasia of the sternum (HP:0006714)2.59854307
53Focal seizures (HP:0007359)2.58285107
54Cerebral inclusion bodies (HP:0100314)2.55772714
55Dysdiadochokinesis (HP:0002075)2.54077132
56Megalencephaly (HP:0001355)2.53952405
57Abnormality of the fovea (HP:0000493)2.53120751
58Vaginal fistula (HP:0004320)2.51935115
59Abnormality of chromosome segregation (HP:0002916)2.51108411
60Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.51108275
61Atonic seizures (HP:0010819)2.50894567
62Akinesia (HP:0002304)2.50538571
63Abnormality of the phalanges of the hallux (HP:0010057)2.49076780
64Torticollis (HP:0000473)2.49008390
65Focal motor seizures (HP:0011153)2.48994521
66Dialeptic seizures (HP:0011146)2.48513712
67Polyphagia (HP:0002591)2.46999104
68Abnormal lung lobation (HP:0002101)2.46984886
69Morphological abnormality of the pyramidal tract (HP:0002062)2.45855667
70EEG with generalized epileptiform discharges (HP:0011198)2.44745321
71Periauricular skin pits (HP:0100277)2.42045870
72Preauricular pit (HP:0004467)2.42045870
73Dysmetria (HP:0001310)2.41684113
74Chromsome breakage (HP:0040012)2.39025862
75Impaired vibration sensation in the lower limbs (HP:0002166)2.38851172
76Intention tremor (HP:0002080)2.37101228
77Supernumerary spleens (HP:0009799)2.36947951
78Ragged-red muscle fibers (HP:0003200)2.35744195
79Hypsarrhythmia (HP:0002521)2.33609073
80Failure to thrive in infancy (HP:0001531)2.32155286
81Poor eye contact (HP:0000817)2.31946519
82Hemiparesis (HP:0001269)2.29644024
83Aplasia/hypoplasia of the humerus (HP:0006507)2.26993890
84Impaired smooth pursuit (HP:0007772)2.26850829
85Cheilitis (HP:0100825)2.25798920
86Abnormality of the corticospinal tract (HP:0002492)2.25302100
87Gaze-evoked nystagmus (HP:0000640)2.24829398
88Pendular nystagmus (HP:0012043)2.20456775
89Neuronal loss in central nervous system (HP:0002529)2.20413052
90Urinary urgency (HP:0000012)2.20281001
91Molar tooth sign on MRI (HP:0002419)2.19562863
92Abnormality of midbrain morphology (HP:0002418)2.19562863
93Agnosia (HP:0010524)2.18974065
94Hyperinsulinemic hypoglycemia (HP:0000825)2.18617390
95Abnormality of the astrocytes (HP:0100707)2.18603546
96Astrocytoma (HP:0009592)2.18603546
97Dyschromatopsia (HP:0007641)2.18519736
98Short humerus (HP:0005792)2.17690770
99Neoplasm of the heart (HP:0100544)2.17540250
100Volvulus (HP:0002580)2.17515263
101Upper limb muscle weakness (HP:0003484)2.15673985
102Sleep apnea (HP:0010535)2.15267296
103Progressive external ophthalmoplegia (HP:0000590)2.14419106
104Focal dystonia (HP:0004373)2.12533310
105Abnormality of the lacrimal duct (HP:0011481)2.11497632
106Abnormality of the labia minora (HP:0012880)2.10527440
107Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.08938224
1083-Methylglutaconic aciduria (HP:0003535)2.06573492
109Abnormality of the salivary glands (HP:0010286)2.06452811
110Inability to walk (HP:0002540)2.05756589
111Intestinal atresia (HP:0011100)2.05615467
112Gastrointestinal atresia (HP:0002589)2.03333546
113Increased circulating renin level (HP:0000848)2.03269555
114Bradykinesia (HP:0002067)2.02962920
115Concave nail (HP:0001598)2.02843850
116Postural instability (HP:0002172)2.02486490
117Postural tremor (HP:0002174)2.02341321
118Generalized tonic-clonic seizures (HP:0002069)2.01809706
119Abnormality of the pubic bones (HP:0003172)2.01611233
120Hemiplegia (HP:0002301)2.01181567
121Exotropia (HP:0000577)1.99401736
122Shawl scrotum (HP:0000049)1.97087234
123Open mouth (HP:0000194)1.96743477
124Aplasia/Hypoplasia of the macula (HP:0008059)1.96346931
125Tented upper lip vermilion (HP:0010804)1.96173348
126Abnormality of ocular smooth pursuit (HP:0000617)1.96153253
127Truncal ataxia (HP:0002078)1.95041351
128Excessive salivation (HP:0003781)1.94383856
129Drooling (HP:0002307)1.94383856
130Renal duplication (HP:0000075)1.93323932
131Abnormal social behavior (HP:0012433)1.92217707
132Impaired social interactions (HP:0000735)1.92217707
133Aqueductal stenosis (HP:0002410)1.91450998
134Heterotopia (HP:0002282)1.90977193
135Esotropia (HP:0000565)1.90574479
136Large earlobe (HP:0009748)1.89949519
137Cutaneous finger syndactyly (HP:0010554)1.89594302
138Duplication of thumb phalanx (HP:0009942)1.89069777
139Malignant neoplasm of the central nervous system (HP:0100836)1.88862534
140Cerebral hypomyelination (HP:0006808)1.87536420
141Abnormality of the nasolacrimal system (HP:0000614)1.87500557
142Limb dystonia (HP:0002451)1.87323036
143Tetraplegia (HP:0002445)1.87026720
144Absence seizures (HP:0002121)1.86736197
145Severe visual impairment (HP:0001141)1.85710162
146Hypoplasia of the brainstem (HP:0002365)1.85181647
147Aplasia/Hypoplasia of the brainstem (HP:0007362)1.85181647
148Papilledema (HP:0001085)1.84552508
149Atrophy/Degeneration involving motor neurons (HP:0007373)1.84185313
150Abnormality of the distal phalanx of the thumb (HP:0009617)1.83073588
151Spastic tetraplegia (HP:0002510)1.83061695
152Broad foot (HP:0001769)1.83025931
153Scanning speech (HP:0002168)1.80346324
154Depression (HP:0000716)1.79237628
155Lissencephaly (HP:0001339)1.79118926
156Thickened helices (HP:0000391)1.78875558
157Visual hallucinations (HP:0002367)1.77952708
158Midline defect of the nose (HP:0004122)1.77861746
159Craniofacial dystonia (HP:0012179)1.77720620
160Reduced antithrombin III activity (HP:0001976)1.77097020
161Abnormal pupillary function (HP:0007686)1.76541265
162Preauricular skin tag (HP:0000384)1.76248044
163Embryonal neoplasm (HP:0002898)1.76129786
164Resting tremor (HP:0002322)1.75969340
165Myokymia (HP:0002411)1.75657570
166Abnormal biliary tract physiology (HP:0012439)1.74807311
167Bile duct proliferation (HP:0001408)1.74807311
168Short 5th finger (HP:0009237)1.74803372
169Hypothermia (HP:0002045)1.71553134
170True hermaphroditism (HP:0010459)1.71186049
171Morphological abnormality of the middle ear (HP:0008609)1.70856930
172Hypokalemic alkalosis (HP:0001949)1.67958348
173Hypoplasia of the corpus callosum (HP:0002079)1.67840554
174Urinary bladder sphincter dysfunction (HP:0002839)1.67471801
175Oligodactyly (hands) (HP:0001180)1.66287553

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK56.05102674
2CDK126.03716972
3GRK64.13012820
4ADRBK23.98676683
5GRK12.96408283
6GRK72.76227929
7NTRK32.49368096
8ERN12.39953942
9CSF1R2.23523350
10MAP2K42.10100613
11TYRO32.09616739
12MAPK72.02000046
13WNK11.89805869
14MARK11.83158408
15MOS1.81010650
16DAPK21.77373680
17NTRK11.74215035
18MAP3K91.71445111
19FGFR21.68172793
20MATK1.68128907
21CASK1.66906485
22TGFBR21.62880304
23MAP2K71.56757647
24NTRK21.53618490
25AKT31.53587437
26ADRBK11.49045377
27PINK11.47566491
28FRK1.45572024
29SIK31.43221412
30MARK21.42721280
31EPHA41.40474400
32CAMK41.40112446
33MAP3K41.39641814
34TAOK11.38103036
35SIK21.35772528
36CAMK2B1.23968649
37TTK1.21629351
38MAP4K21.18601010
39SGK4941.17367258
40SGK2231.17367258
41PRPF4B1.15148725
42PLK41.13967622
43PRKG21.12527485
44CAMKK21.08658534
45MAPK131.04420658
46KSR21.02942557
47LATS20.98232142
48ARAF0.97425710
49MAP3K120.91996105
50PRKCZ0.91123647
51CAMKK10.90597624
52CDK70.88113143
53SGK20.87103595
54MINK10.86106307
55PKN10.84741211
56PRKCG0.83016628
57ROCK20.82709780
58MAPK120.81647641
59SIK10.79631671
60FES0.78149794
61MST40.77800477
62MAP2K60.76147471
63PAK60.75967552
64DYRK1A0.75575638
65PLK20.73515737
66HIPK20.72024666
67EPHA20.71699571
68DYRK20.70840162
69MAP3K110.69830397
70TSSK60.68527933
71INSRR0.67857609
72ROCK10.67555067
73CHEK20.65818240
74TNIK0.63746964
75EPHB20.62959070
76STK100.61130532
77CDK30.60284824
78STK110.59916245
79RIPK40.59646422
80CDK180.59643326
81UHMK10.59369166
82PAK30.59102011
83PRKG10.58764002
84PAK40.58578463
85BRD40.58574723
86CDK150.58144798
87EIF2AK20.56606622
88STK390.55145186
89FYN0.52110732
90CDK50.51839477
91CDK11A0.50650329
92FGFR30.49832961
93CDK140.49657465
94MAP3K10.49241302
95NME10.49234186
96TNK20.48395713
97AKT20.48094209
98MAP2K10.46784999
99ALK0.46238338
100MAPK80.46033648
101CAMK2G0.45932941
102CDK190.45920943
103CDK80.45430884
104FGR0.43388593
105SGK10.42527925
106MYLK0.42038033
107YES10.41346134
108CAMK2A0.40894167
109PRKCE0.39534269
110STK380.39260051
111CSNK1A10.38793878
112MAP3K60.37418502
113SGK30.37404137
114CLK10.37113130
115PRKCH0.36944052
116PRKCI0.36693254
117KSR10.35986317
118PRKCB0.35940008
119PLK10.35760940
120DAPK10.34409390
121CHEK10.34175213
122WEE10.33525391
123PRKCA0.33420273
124MAPK90.33366467
125PLK30.33249407
126PRKACA0.32289358
127IGF1R0.31266318
128CSNK1E0.31174297
129MAPK100.30540318
130OXSR10.29078879
131CSNK1G20.27985233
132WNK30.27957553
133PRKACB0.26817694
134PRKCD0.26223905
135RPS6KA30.26221963
136MAPK40.26213330
137CAMK10.25326086
138PHKG20.24303688
139PHKG10.24303688
140BCR0.24011813
141BRAF0.23777239
142GSK3B0.22250166
143BMPR20.21891035
144PNCK0.20624941
145CSNK1G30.20452946
146CSK0.19804392
147MAP3K70.19064351
148PRKACG0.18608303

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.64587041
2Vitamin B6 metabolism_Homo sapiens_hsa007504.22792875
3Nicotine addiction_Homo sapiens_hsa050333.53469741
4GABAergic synapse_Homo sapiens_hsa047272.53898342
5Taste transduction_Homo sapiens_hsa047422.50029735
6Serotonergic synapse_Homo sapiens_hsa047262.38391109
7Synaptic vesicle cycle_Homo sapiens_hsa047212.21670138
8Glutamatergic synapse_Homo sapiens_hsa047242.21034342
9Fructose and mannose metabolism_Homo sapiens_hsa000512.07430212
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.00166272
11Long-term potentiation_Homo sapiens_hsa047201.81814471
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.80622704
13Long-term depression_Homo sapiens_hsa047301.79510860
14Arachidonic acid metabolism_Homo sapiens_hsa005901.71565215
15Morphine addiction_Homo sapiens_hsa050321.68399474
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.64153514
17Collecting duct acid secretion_Homo sapiens_hsa049661.60374803
18Dopaminergic synapse_Homo sapiens_hsa047281.58303098
19Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.57881080
20Circadian entrainment_Homo sapiens_hsa047131.55520474
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.49037302
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.48469123
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46479254
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.46435633
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46405669
26Olfactory transduction_Homo sapiens_hsa047401.46214733
27Amphetamine addiction_Homo sapiens_hsa050311.45528781
28Calcium signaling pathway_Homo sapiens_hsa040201.43445400
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.42646233
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40466294
31Nitrogen metabolism_Homo sapiens_hsa009101.36926410
32Linoleic acid metabolism_Homo sapiens_hsa005911.33651664
33Salivary secretion_Homo sapiens_hsa049701.32519436
34Galactose metabolism_Homo sapiens_hsa000521.31995620
35Oxidative phosphorylation_Homo sapiens_hsa001901.23940534
36African trypanosomiasis_Homo sapiens_hsa051431.16597596
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.15836895
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.15522853
39Renin secretion_Homo sapiens_hsa049241.12772067
40Cocaine addiction_Homo sapiens_hsa050301.11594285
41Axon guidance_Homo sapiens_hsa043601.10595466
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09768500
43Phospholipase D signaling pathway_Homo sapiens_hsa040721.08668085
44Ovarian steroidogenesis_Homo sapiens_hsa049131.08496136
45Cardiac muscle contraction_Homo sapiens_hsa042601.06675649
46Ether lipid metabolism_Homo sapiens_hsa005651.06516709
47GnRH signaling pathway_Homo sapiens_hsa049121.04694033
48Oxytocin signaling pathway_Homo sapiens_hsa049211.03840273
49Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.99856410
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98628813
51Choline metabolism in cancer_Homo sapiens_hsa052310.92410640
52Alzheimers disease_Homo sapiens_hsa050100.91650583
53cAMP signaling pathway_Homo sapiens_hsa040240.90909783
54Parkinsons disease_Homo sapiens_hsa050120.89120591
55mTOR signaling pathway_Homo sapiens_hsa041500.88086743
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87876418
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.86312697
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83747405
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83289220
60Ras signaling pathway_Homo sapiens_hsa040140.81193126
61Cholinergic synapse_Homo sapiens_hsa047250.81169191
62Gap junction_Homo sapiens_hsa045400.81158302
63Insulin secretion_Homo sapiens_hsa049110.80625924
64Oocyte meiosis_Homo sapiens_hsa041140.77409289
65Rap1 signaling pathway_Homo sapiens_hsa040150.74244649
66ErbB signaling pathway_Homo sapiens_hsa040120.70019432
67Pancreatic secretion_Homo sapiens_hsa049720.70015394
68Selenocompound metabolism_Homo sapiens_hsa004500.68241687
69Wnt signaling pathway_Homo sapiens_hsa043100.67931004
70Huntingtons disease_Homo sapiens_hsa050160.67194764
71Prion diseases_Homo sapiens_hsa050200.66976914
72Vibrio cholerae infection_Homo sapiens_hsa051100.66559212
73Butanoate metabolism_Homo sapiens_hsa006500.65161063
74Inositol phosphate metabolism_Homo sapiens_hsa005620.64854562
75MAPK signaling pathway_Homo sapiens_hsa040100.64384439
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62205769
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62086507
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61958816
79One carbon pool by folate_Homo sapiens_hsa006700.61250923
80Hedgehog signaling pathway_Homo sapiens_hsa043400.61031711
81Pentose phosphate pathway_Homo sapiens_hsa000300.60121101
82Thyroid hormone synthesis_Homo sapiens_hsa049180.59003424
83Phototransduction_Homo sapiens_hsa047440.57866792
84Bile secretion_Homo sapiens_hsa049760.56764420
85Pyruvate metabolism_Homo sapiens_hsa006200.56676705
86Type II diabetes mellitus_Homo sapiens_hsa049300.55831895
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54889586
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54552902
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.54227854
90mRNA surveillance pathway_Homo sapiens_hsa030150.53238146
91Fatty acid elongation_Homo sapiens_hsa000620.53158570
92Gastric acid secretion_Homo sapiens_hsa049710.52352281
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51994623
94Thyroid cancer_Homo sapiens_hsa052160.51315310
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49323037
96Basal transcription factors_Homo sapiens_hsa030220.49080579
97Melanogenesis_Homo sapiens_hsa049160.48146897
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46865646
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44402972
100Pathways in cancer_Homo sapiens_hsa052000.42769115
101Dilated cardiomyopathy_Homo sapiens_hsa054140.42766036
102Fatty acid biosynthesis_Homo sapiens_hsa000610.41287761
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41220138
104Alcoholism_Homo sapiens_hsa050340.40898265
105Histidine metabolism_Homo sapiens_hsa003400.40756681
106Protein export_Homo sapiens_hsa030600.40552910
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40193778
108Non-small cell lung cancer_Homo sapiens_hsa052230.39661760
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39240201
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.37142824
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36944353
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36646344
113Mineral absorption_Homo sapiens_hsa049780.35084049
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.34117088
115Fanconi anemia pathway_Homo sapiens_hsa034600.33628947
116Regulation of autophagy_Homo sapiens_hsa041400.33112172
117Arginine biosynthesis_Homo sapiens_hsa002200.32658174
118Melanoma_Homo sapiens_hsa052180.31393890
119Sulfur relay system_Homo sapiens_hsa041220.31258490
120Dorso-ventral axis formation_Homo sapiens_hsa043200.30874940
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30872871
122Rheumatoid arthritis_Homo sapiens_hsa053230.30815632
123Glioma_Homo sapiens_hsa052140.30775763
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30020634
125Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30016168
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.29052138
127Basal cell carcinoma_Homo sapiens_hsa052170.28809649
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28790520
129Glucagon signaling pathway_Homo sapiens_hsa049220.28767613
130VEGF signaling pathway_Homo sapiens_hsa043700.28497867
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27756536
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27336218
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26362854
134Estrogen signaling pathway_Homo sapiens_hsa049150.26334838
135Circadian rhythm_Homo sapiens_hsa047100.23340337
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.22801882
137Tryptophan metabolism_Homo sapiens_hsa003800.22705270
138Arginine and proline metabolism_Homo sapiens_hsa003300.15883999

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »