MAGEF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene encodes a member of the MAGE superfamily. It is ubiquitously expressed in normal tissues and in tumor cells. This gene includes a microsatellite repeat in the coding region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.69424305
2establishment of mitochondrion localization (GO:0051654)4.32202861
3establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.78940643
4mitochondrion transport along microtubule (GO:0047497)3.78940643
5axonal fasciculation (GO:0007413)3.68656079
6postsynaptic membrane organization (GO:0001941)3.66496899
7nucleobase catabolic process (GO:0046113)3.60337812
8neuron recognition (GO:0008038)3.54410810
9cell migration in hindbrain (GO:0021535)3.53155136
10protein localization to synapse (GO:0035418)3.36439263
11presynaptic membrane assembly (GO:0097105)3.32964882
12presynaptic membrane organization (GO:0097090)3.28708105
13neuron cell-cell adhesion (GO:0007158)3.22310175
14substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.18352932
15substrate-independent telencephalic tangential migration (GO:0021826)3.18352932
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.04307465
17body morphogenesis (GO:0010171)2.94041092
18adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.93635469
19layer formation in cerebral cortex (GO:0021819)2.93538995
20viral transcription (GO:0019083)2.90096439
21synaptic vesicle maturation (GO:0016188)2.89511350
22nonmotile primary cilium assembly (GO:0035058)2.88484856
23translational termination (GO:0006415)2.84804707
24axon extension (GO:0048675)2.78980964
25vocalization behavior (GO:0071625)2.76233453
26dendritic spine morphogenesis (GO:0060997)2.73748518
27ribosomal small subunit biogenesis (GO:0042274)2.73580969
28spinal cord association neuron differentiation (GO:0021527)2.69704906
29neuronal ion channel clustering (GO:0045161)2.64526721
30short-term memory (GO:0007614)2.64484465
31chaperone-mediated protein transport (GO:0072321)2.63987227
32regulation of short-term neuronal synaptic plasticity (GO:0048172)2.63418520
33behavioral response to nicotine (GO:0035095)2.58045294
34synapse assembly (GO:0007416)2.57901923
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.55493803
36cerebral cortex radially oriented cell migration (GO:0021799)2.52282111
37positive regulation of dendritic spine morphogenesis (GO:0061003)2.51696854
38retinal ganglion cell axon guidance (GO:0031290)2.47808826
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.45510505
40spinal cord development (GO:0021510)2.44159858
41embryonic body morphogenesis (GO:0010172)2.43951391
42mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.43522565
43convergent extension (GO:0060026)2.41998919
44calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.41986819
45paraxial mesoderm development (GO:0048339)2.41823242
46neurofilament cytoskeleton organization (GO:0060052)2.41755104
47cotranslational protein targeting to membrane (GO:0006613)2.38895627
48positive regulation of mitochondrial fission (GO:0090141)2.36930480
49SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.36853940
50positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.35709762
51positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.35413991
52L-serine metabolic process (GO:0006563)2.35195977
53positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.34650501
54protein targeting to ER (GO:0045047)2.34327938
55transmission of nerve impulse (GO:0019226)2.34257807
56lens fiber cell development (GO:0070307)2.34205986
57neuron projection extension involved in neuron projection guidance (GO:1902284)2.33335761
58axon extension involved in axon guidance (GO:0048846)2.33335761
59translational elongation (GO:0006414)2.32989951
60auditory behavior (GO:0031223)2.32950815
61behavioral response to cocaine (GO:0048148)2.32914611
62maturation of SSU-rRNA (GO:0030490)2.32720573
63cellular protein complex disassembly (GO:0043624)2.31252839
64protein complex disassembly (GO:0043241)2.29323440
65establishment of protein localization to endoplasmic reticulum (GO:0072599)2.28548924
66hippocampus development (GO:0021766)2.28261136
67protein-DNA complex disassembly (GO:0032986)2.27971523
68nucleosome disassembly (GO:0006337)2.27971523
69energy coupled proton transport, down electrochemical gradient (GO:0015985)2.27705861
70ATP synthesis coupled proton transport (GO:0015986)2.27705861
71apical protein localization (GO:0045176)2.27360096
72dendrite morphogenesis (GO:0048813)2.27316849
73neurotransmitter-gated ion channel clustering (GO:0072578)2.26420666
74viral life cycle (GO:0019058)2.26399790
75positive regulation of synapse assembly (GO:0051965)2.25864466
76macromolecular complex disassembly (GO:0032984)2.25596615
77camera-type eye morphogenesis (GO:0048593)2.25434434
78forebrain neuron differentiation (GO:0021879)2.25265382
79glutamate secretion (GO:0014047)2.24406909
80protein localization to endoplasmic reticulum (GO:0070972)2.22299252
81neuron projection extension (GO:1990138)2.22214557
82cell proliferation in forebrain (GO:0021846)2.21070828
83ribosomal large subunit biogenesis (GO:0042273)2.21019432
84synapse organization (GO:0050808)2.18604131
85establishment or maintenance of monopolar cell polarity (GO:0061339)2.16721413
86establishment of monopolar cell polarity (GO:0061162)2.16721413
87dendritic spine organization (GO:0097061)2.16387884
88pattern specification involved in kidney development (GO:0061004)2.16130700
89positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.15048829
90mechanosensory behavior (GO:0007638)2.14070205
91regulation of glutamate receptor signaling pathway (GO:1900449)2.12133914
92planar cell polarity pathway involved in neural tube closure (GO:0090179)2.11930608
93axon cargo transport (GO:0008088)2.10253089
94dendrite development (GO:0016358)2.08981134
95synaptic vesicle exocytosis (GO:0016079)2.08541408
96regulation of synaptic vesicle exocytosis (GO:2000300)2.07040696
97neurotransmitter secretion (GO:0007269)2.06646609
98neuron migration (GO:0001764)2.05721734
99negative regulation of microtubule polymerization (GO:0031115)2.05684044
100cytoskeleton-dependent intracellular transport (GO:0030705)2.05085078

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.29807603
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.26211693
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.12031862
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.66030743
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.03881148
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.38392906
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.25175047
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.02990574
9CBX2_27304074_Chip-Seq_ESCs_Mouse1.98335722
10EED_16625203_ChIP-ChIP_MESCs_Mouse1.97743843
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.95030138
12MYC_18555785_ChIP-Seq_MESCs_Mouse1.89399544
13PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.89116465
14REST_21632747_ChIP-Seq_MESCs_Mouse1.78684205
15EZH2_27294783_Chip-Seq_ESCs_Mouse1.76709678
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73887553
17ERG_21242973_ChIP-ChIP_JURKAT_Human1.73525237
18RNF2_27304074_Chip-Seq_ESCs_Mouse1.71651405
19RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.71556736
20EZH2_18974828_ChIP-Seq_MESCs_Mouse1.71385680
21RNF2_18974828_ChIP-Seq_MESCs_Mouse1.71385680
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.71118985
23REST_18959480_ChIP-ChIP_MESCs_Mouse1.69515391
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69308170
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61404356
26XRN2_22483619_ChIP-Seq_HELA_Human1.59828932
27RNF2_27304074_Chip-Seq_NSC_Mouse1.53286055
28THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53099165
29ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52729476
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.51522234
31GATA1_26923725_Chip-Seq_HPCs_Mouse1.51041609
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46696962
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46023652
34OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.45641727
35RING1B_27294783_Chip-Seq_ESCs_Mouse1.38721584
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.36962830
37KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34373403
38SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33142836
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32811604
40SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.30810192
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30803696
42TP53_20018659_ChIP-ChIP_R1E_Mouse1.29523506
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.27356032
44SOX2_16153702_ChIP-ChIP_HESCs_Human1.26403552
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26242354
46EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25614702
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24151032
48TTF2_22483619_ChIP-Seq_HELA_Human1.22125315
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21092689
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20973090
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19983470
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19232915
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.18247101
54RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17761131
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17388546
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16205876
57MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14715897
58SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14373286
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.14366884
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.12017198
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09667535
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.09495890
63TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.07867093
64SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07745690
65SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.07295170
66* GABP_19822575_ChIP-Seq_HepG2_Human1.07011374
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04821561
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04580033
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04354279
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03049339
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02444840
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01835487
73ZNF263_19887448_ChIP-Seq_K562_Human1.01813181
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01809085
75CTCF_27219007_Chip-Seq_Bcells_Human1.01142492
76TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00545525
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00391011
78WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99740535
79REST_19997604_ChIP-ChIP_NEURONS_Mouse0.99412566
80CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99356465
81MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99268736
82SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98897041
83KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.98719679
84SOX3_22085726_ChIP-Seq_NPCs_Mouse0.97788949
85MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97258273
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96017379
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94472183
88CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.92843024
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92205894
90SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91842285
91GABP_17652178_ChIP-ChIP_JURKAT_Human0.91552922
92NANOG_21062744_ChIP-ChIP_HESCs_Human0.91532902
93CTCF_18555785_ChIP-Seq_MESCs_Mouse0.86849583
94EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.86476067
95CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86138738
96MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.85513331
97POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.84788068
98MYCN_18555785_ChIP-Seq_MESCs_Mouse0.84731746
99FOXP1_21924763_ChIP-Seq_HESCs_Human0.84697230
100ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83637853

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting3.37831717
2MP0004859_abnormal_synaptic_plasticity2.82562631
3MP0000778_abnormal_nervous_system2.56428313
4MP0003121_genomic_imprinting2.39028550
5MP0003787_abnormal_imprinting2.38773010
6MP0000566_synostosis2.37370550
7MP0003123_paternal_imprinting2.35351014
8MP0002822_catalepsy2.25186801
9MP0006292_abnormal_olfactory_placode2.18481288
10MP0003880_abnormal_central_pattern2.15687051
11MP0002653_abnormal_ependyma_morphology2.12479544
12MP0001529_abnormal_vocalization2.04343474
13MP0009379_abnormal_foot_pigmentation1.96668003
14MP0005423_abnormal_somatic_nervous1.96337349
15MP0004270_analgesia1.95734280
16MP0006276_abnormal_autonomic_nervous1.89084592
17MP0005499_abnormal_olfactory_system1.79306967
18MP0005394_taste/olfaction_phenotype1.79306967
19MP0003635_abnormal_synaptic_transmissio1.76037732
20MP0001984_abnormal_olfaction1.71596950
21MP0000955_abnormal_spinal_cord1.71465138
22MP0001188_hyperpigmentation1.60035009
23MP0008789_abnormal_olfactory_epithelium1.58850814
24MP0002184_abnormal_innervation1.57049721
25MP0002734_abnormal_mechanical_nocicepti1.55328776
26MP0003136_yellow_coat_color1.54683056
27MP0001293_anophthalmia1.52462527
28MP0002063_abnormal_learning/memory/cond1.51277450
29MP0000049_abnormal_middle_ear1.50702036
30MP0000537_abnormal_urethra_morphology1.48899537
31MP0010030_abnormal_orbit_morphology1.46560206
32MP0002638_abnormal_pupillary_reflex1.46437091
33MP0004133_heterotaxia1.45009683
34MP0003861_abnormal_nervous_system1.43828163
35MP0003942_abnormal_urinary_system1.39199339
36MP0002557_abnormal_social/conspecific_i1.36837379
37MP0003937_abnormal_limbs/digits/tail_de1.36083503
38MP0002572_abnormal_emotion/affect_behav1.35033887
39MP0000631_abnormal_neuroendocrine_gland1.33713952
40MP0003890_abnormal_embryonic-extraembry1.33110677
41MP0002909_abnormal_adrenal_gland1.31451261
42MP0002152_abnormal_brain_morphology1.30884871
43MP0001299_abnormal_eye_distance/1.28972286
44MP0004142_abnormal_muscle_tone1.26009766
45MP0004811_abnormal_neuron_physiology1.25942518
46MP0002233_abnormal_nose_morphology1.25751017
47MP0000534_abnormal_ureter_morphology1.25633564
48MP0002882_abnormal_neuron_morphology1.24995348
49MP0002697_abnormal_eye_size1.23677826
50MP0002735_abnormal_chemical_nociception1.21630172
51MP0003938_abnormal_ear_development1.21536371
52MP0002272_abnormal_nervous_system1.21524216
53MP0002938_white_spotting1.21072817
54MP0004858_abnormal_nervous_system1.16274487
55MP0009745_abnormal_behavioral_response1.15627637
56MP0002752_abnormal_somatic_nervous1.15512531
57MP0003385_abnormal_body_wall1.13639922
58MP0002249_abnormal_larynx_morphology1.10495021
59MP0001968_abnormal_touch/_nociception1.10195782
60MP0002736_abnormal_nociception_after1.09039197
61MP0002234_abnormal_pharynx_morphology1.04145333
62MP0001286_abnormal_eye_development1.03866125
63MP0000579_abnormal_nail_morphology1.03628426
64MP0004885_abnormal_endolymph1.03615032
65MP0002064_seizures1.03380776
66MP0003755_abnormal_palate_morphology1.03047052
67MP0001346_abnormal_lacrimal_gland1.01422499
68MP0000026_abnormal_inner_ear0.97558676
69MP0002067_abnormal_sensory_capabilities0.96669437
70MP0001970_abnormal_pain_threshold0.96271437
71MP0005248_abnormal_Harderian_gland0.95359688
72MP0001486_abnormal_startle_reflex0.94288927
73MP0003119_abnormal_digestive_system0.92996654
74MP0009046_muscle_twitch0.92837736
75MP0002733_abnormal_thermal_nociception0.91561770
76MP0008877_abnormal_DNA_methylation0.91509812
77MP0002116_abnormal_craniofacial_bone0.90833222
78MP0002081_perinatal_lethality0.90094312
79MP0002092_abnormal_eye_morphology0.88056770
80MP0003567_abnormal_fetal_cardiomyocyte0.86761712
81MP0002066_abnormal_motor_capabilities/c0.86558108
82MP0001502_abnormal_circadian_rhythm0.84781117
83MP0003315_abnormal_perineum_morphology0.84092917
84MP0003283_abnormal_digestive_organ0.84053758
85MP0008932_abnormal_embryonic_tissue0.83192252
86MP0006072_abnormal_retinal_apoptosis0.79158408
87MP0002084_abnormal_developmental_patter0.78878289
88MP0002085_abnormal_embryonic_tissue0.77460740
89MP0005195_abnormal_posterior_eye0.77300894
90MP0002751_abnormal_autonomic_nervous0.76911747
91MP0009672_abnormal_birth_weight0.75647019
92MP0005187_abnormal_penis_morphology0.73999902
93MP0003329_amyloid_beta_deposits0.73764767
94MP0005391_vision/eye_phenotype0.73566424
95MP0001485_abnormal_pinna_reflex0.72930686
96MP0005386_behavior/neurological_phenoty0.72688990
97MP0004924_abnormal_behavior0.72688990
98MP0009780_abnormal_chondrocyte_physiolo0.72505195
99MP0001440_abnormal_grooming_behavior0.72452075
100MP0009250_abnormal_appendicular_skeleto0.72249882

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.03815511
2Gait imbalance (HP:0002141)2.70238478
3Cortical dysplasia (HP:0002539)2.69751748
4Partial duplication of thumb phalanx (HP:0009944)2.57415528
5Septo-optic dysplasia (HP:0100842)2.55539504
6Abnormality of the labia minora (HP:0012880)2.50658571
7Rib fusion (HP:0000902)2.30325703
8Congenital primary aphakia (HP:0007707)2.28470586
9Polyphagia (HP:0002591)2.24697512
10Partial duplication of the phalanx of hand (HP:0009999)2.22924624
11Vaginal atresia (HP:0000148)2.22807497
12Nephrogenic diabetes insipidus (HP:0009806)2.20307113
13Anophthalmia (HP:0000528)2.19514438
14Limb dystonia (HP:0002451)2.19217248
15Genital tract atresia (HP:0001827)2.12673678
16Turricephaly (HP:0000262)2.12599542
17Medial flaring of the eyebrow (HP:0010747)2.12294264
18Abnormality of the corticospinal tract (HP:0002492)2.11850704
19Hepatoblastoma (HP:0002884)2.06871964
20Overriding aorta (HP:0002623)2.05789862
21Double outlet right ventricle (HP:0001719)2.02420381
22Congenital malformation of the right heart (HP:0011723)2.02420381
23Drooling (HP:0002307)2.02374948
24Poor suck (HP:0002033)2.01189138
25Sleep apnea (HP:0010535)2.01100327
26Epileptic encephalopathy (HP:0200134)1.96845765
27Lissencephaly (HP:0001339)1.88270636
28Specific learning disability (HP:0001328)1.87528281
29Oligodactyly (HP:0012165)1.87463520
30Reticulocytopenia (HP:0001896)1.86723642
31Aplasia/Hypoplasia of the brainstem (HP:0007362)1.85685914
32Hypoplasia of the brainstem (HP:0002365)1.85685914
33Absent septum pellucidum (HP:0001331)1.85525708
34Poor coordination (HP:0002370)1.84069729
35Shawl scrotum (HP:0000049)1.83172787
36Abnormality of cells of the erythroid lineage (HP:0012130)1.81704263
37Oligodactyly (hands) (HP:0001180)1.80431088
38Pancreatic fibrosis (HP:0100732)1.80152698
39Abnormality of the diencephalon (HP:0010662)1.79729666
40Failure to thrive in infancy (HP:0001531)1.78786459
41Aplasia involving bones of the upper limbs (HP:0009823)1.77766869
42Aplasia of the phalanges of the hand (HP:0009802)1.77766869
43Aplasia involving bones of the extremities (HP:0009825)1.77766869
44Insomnia (HP:0100785)1.76525189
45Renal dysplasia (HP:0000110)1.75105853
46Stenosis of the external auditory canal (HP:0000402)1.74622699
47Abnormality of the aortic arch (HP:0012303)1.73903522
48Excessive salivation (HP:0003781)1.72202830
49Bifid tongue (HP:0010297)1.70940073
50Retinal dysplasia (HP:0007973)1.68081876
51Elfin facies (HP:0004428)1.67415343
52Cutaneous syndactyly (HP:0012725)1.66198775
53Myelomeningocele (HP:0002475)1.64520716
54Focal motor seizures (HP:0011153)1.64500480
55Morphological abnormality of the middle ear (HP:0008609)1.64478779
56Generalized hypotonia (HP:0001290)1.63016249
57Molar tooth sign on MRI (HP:0002419)1.62368232
58Abnormality of midbrain morphology (HP:0002418)1.62368232
59Pachygyria (HP:0001302)1.61627087
60Esophageal atresia (HP:0002032)1.60841287
61Micropenis (HP:0000054)1.60201919
62Cutaneous finger syndactyly (HP:0010554)1.60116610
63Broad alveolar ridges (HP:0000187)1.59348265
64Agitation (HP:0000713)1.57711139
65Renal duplication (HP:0000075)1.57207418
66Acute necrotizing encephalopathy (HP:0006965)1.57148267
67Spastic tetraplegia (HP:0002510)1.56362716
68Scrotal hypoplasia (HP:0000046)1.56233286
69Macrocytic anemia (HP:0001972)1.56228167
70Duplication of thumb phalanx (HP:0009942)1.55710033
71Hemivertebrae (HP:0002937)1.55338954
72Postaxial hand polydactyly (HP:0001162)1.54509200
73Abnormality of the septum pellucidum (HP:0007375)1.54433729
74Focal seizures (HP:0007359)1.53482502
75Split foot (HP:0001839)1.51666066
76Esotropia (HP:0000565)1.51308508
77Hyperacusis (HP:0010780)1.51275955
78Facial cleft (HP:0002006)1.51168436
79Abnormal mitochondria in muscle tissue (HP:0008316)1.49800874
80Megalencephaly (HP:0001355)1.49555743
81Preaxial hand polydactyly (HP:0001177)1.49116586
82Optic nerve hypoplasia (HP:0000609)1.48902608
83Broad distal phalanx of finger (HP:0009836)1.48522166
84Decreased testicular size (HP:0008734)1.48340054
85Broad foot (HP:0001769)1.48268488
86Anencephaly (HP:0002323)1.48099363
87Renovascular hypertension (HP:0100817)1.47039736
88Hyperthyroidism (HP:0000836)1.47034080
89Abnormality of the phalanges of the hallux (HP:0010057)1.46476294
90Acute encephalopathy (HP:0006846)1.46277614
91Impaired vibration sensation in the lower limbs (HP:0002166)1.45592081
92Abnormal connection of the cardiac segments (HP:0011545)1.45235136
93Abnormal ventriculo-arterial connection (HP:0011563)1.45235136
94Transposition of the great arteries (HP:0001669)1.45235136
95Coronal craniosynostosis (HP:0004440)1.44961731
96Hypsarrhythmia (HP:0002521)1.43731949
97Increased nuchal translucency (HP:0010880)1.43429875
98Hyperglycinemia (HP:0002154)1.42409161
99Maternal diabetes (HP:0009800)1.42356435
100High anterior hairline (HP:0009890)1.42230348

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.99649816
2MARK13.74226325
3DYRK22.55957459
4NTRK22.28769409
5MAP2K72.27760084
6MINK12.07101147
7CDC72.01385215
8MAP3K91.99521337
9BCR1.97340207
10PRKD31.96520539
11TNIK1.94207634
12ARAF1.78852460
13MAP3K41.78624640
14NTRK11.62899169
15EPHA41.58912527
16UHMK11.50063236
17CSNK1G21.43533683
18DYRK31.41380196
19PNCK1.40843932
20EPHB21.39307794
21STK161.39159848
22CDK191.36274389
23SRPK11.32237644
24DYRK1B1.29594626
25WNK31.29398203
26BCKDK1.28687650
27PKN21.21892235
28LIMK11.20921172
29LATS21.19642856
30TYRO31.19345407
31MAP2K41.19312691
32MAPK131.17047036
33PRKCG1.15771485
34CSNK1G31.13185110
35PINK11.09300136
36WNK41.06887780
37SIK21.06873367
38CDK141.01826279
39RPS6KA40.99302007
40CSNK1A1L0.95300285
41BRAF0.93894044
42AURKA0.93624002
43CDK11A0.92870695
44CDK150.92013200
45CSNK1E0.91523547
46CDK180.91453843
47NTRK30.90639102
48FGFR20.88656104
49PHKG10.88440271
50PHKG20.88440271
51CSNK1G10.88110727
52PIM20.86130138
53DMPK0.84226149
54CDK50.84150376
55PAK60.83428742
56TRIM280.82981458
57DYRK1A0.81082734
58ICK0.79592965
59CAMKK10.76462100
60SGK4940.74797939
61SGK2230.74797939
62CAMK1G0.72671935
63MKNK10.69336339
64MKNK20.67104016
65MAP4K20.66601213
66PIK3CA0.64392362
67PLK10.64242626
68PAK30.62443112
69BRSK10.59764711
70KSR10.59415625
71AKT20.58971355
72TESK10.57354697
73PRKCH0.56569802
74EEF2K0.55989051
75ALK0.55235099
76PRKCZ0.55072567
77CHEK20.55054523
78MAP3K120.54574762
79PLK40.54500317
80CAMK1D0.53633194
81ATR0.53492568
82STK38L0.53347024
83LRRK20.53043794
84RPS6KA20.51234244
85PRKDC0.50714750
86NEK20.49840822
87PRKCI0.48609649
88CSNK2A20.48395277
89SIK10.48370907
90CAMK2G0.46989108
91CSNK1A10.46777915
92CDK70.46323905
93TRIB30.46283783
94TTK0.45793320
95CAMK2B0.44987135
96NEK10.44441440
97PLK20.44250523
98CAMK2A0.43558485
99CDK20.42689878
100NME10.42543360

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.73555197
2Nicotine addiction_Homo sapiens_hsa050332.47764662
3Oxidative phosphorylation_Homo sapiens_hsa001902.20488304
4Cardiac muscle contraction_Homo sapiens_hsa042602.20174101
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.04152383
6Parkinsons disease_Homo sapiens_hsa050122.03619150
7Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.89086798
8Steroid biosynthesis_Homo sapiens_hsa001001.87762895
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78405194
10Basal cell carcinoma_Homo sapiens_hsa052171.66036407
11Synaptic vesicle cycle_Homo sapiens_hsa047211.64762175
12Huntingtons disease_Homo sapiens_hsa050161.63257439
13Axon guidance_Homo sapiens_hsa043601.62025039
14Protein export_Homo sapiens_hsa030601.50353050
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.46550228
16Hedgehog signaling pathway_Homo sapiens_hsa043401.45879919
17Hippo signaling pathway_Homo sapiens_hsa043901.41761961
18Alzheimers disease_Homo sapiens_hsa050101.41675882
19GABAergic synapse_Homo sapiens_hsa047271.41556025
20Sulfur relay system_Homo sapiens_hsa041221.36830256
21Spliceosome_Homo sapiens_hsa030401.34694489
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23408783
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22629996
24Dopaminergic synapse_Homo sapiens_hsa047281.22483349
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21484625
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20670907
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20541526
28Pyruvate metabolism_Homo sapiens_hsa006201.16173545
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15472259
30Biosynthesis of amino acids_Homo sapiens_hsa012301.14251112
31Cocaine addiction_Homo sapiens_hsa050301.13951543
32Morphine addiction_Homo sapiens_hsa050321.12629623
33mRNA surveillance pathway_Homo sapiens_hsa030151.09996169
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09007445
35Glutamatergic synapse_Homo sapiens_hsa047241.06938904
36Insulin secretion_Homo sapiens_hsa049111.03262578
37Wnt signaling pathway_Homo sapiens_hsa043101.02894519
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99286261
39Butanoate metabolism_Homo sapiens_hsa006500.99031488
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98666540
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98119787
42RNA polymerase_Homo sapiens_hsa030200.97751435
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97614141
44RNA transport_Homo sapiens_hsa030130.97473644
45Propanoate metabolism_Homo sapiens_hsa006400.95896638
46Vibrio cholerae infection_Homo sapiens_hsa051100.95314263
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94046845
48Circadian entrainment_Homo sapiens_hsa047130.93271542
49Melanogenesis_Homo sapiens_hsa049160.92701268
50Base excision repair_Homo sapiens_hsa034100.91553374
51Arginine and proline metabolism_Homo sapiens_hsa003300.91132845
52Notch signaling pathway_Homo sapiens_hsa043300.90253532
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88275189
54Folate biosynthesis_Homo sapiens_hsa007900.88000140
55Amphetamine addiction_Homo sapiens_hsa050310.87742410
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83303067
57Cholinergic synapse_Homo sapiens_hsa047250.82135902
58Carbon metabolism_Homo sapiens_hsa012000.80707783
59Vitamin B6 metabolism_Homo sapiens_hsa007500.79042185
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77990520
61Fatty acid elongation_Homo sapiens_hsa000620.77232832
62Basal transcription factors_Homo sapiens_hsa030220.76412502
63DNA replication_Homo sapiens_hsa030300.76286683
64Mismatch repair_Homo sapiens_hsa034300.76239136
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75401274
66Tight junction_Homo sapiens_hsa045300.74580706
67Fatty acid metabolism_Homo sapiens_hsa012120.73473686
68Gap junction_Homo sapiens_hsa045400.73135547
69RNA degradation_Homo sapiens_hsa030180.72108640
70Phototransduction_Homo sapiens_hsa047440.70886757
71Dilated cardiomyopathy_Homo sapiens_hsa054140.69416421
72Taste transduction_Homo sapiens_hsa047420.69395236
73Alcoholism_Homo sapiens_hsa050340.66661887
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66545816
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.64906902
76Oocyte meiosis_Homo sapiens_hsa041140.60515084
77beta-Alanine metabolism_Homo sapiens_hsa004100.60249261
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60190152
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58764195
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.58649760
81Collecting duct acid secretion_Homo sapiens_hsa049660.57500488
82Endometrial cancer_Homo sapiens_hsa052130.56064723
83Serotonergic synapse_Homo sapiens_hsa047260.55174748
84Fanconi anemia pathway_Homo sapiens_hsa034600.53804683
85ErbB signaling pathway_Homo sapiens_hsa040120.53661061
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.52934908
87Long-term potentiation_Homo sapiens_hsa047200.52817263
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51966434
89Thyroid hormone synthesis_Homo sapiens_hsa049180.51949654
90Long-term depression_Homo sapiens_hsa047300.50750137
91AMPK signaling pathway_Homo sapiens_hsa041520.50272512
92Nucleotide excision repair_Homo sapiens_hsa034200.49702822
93Pyrimidine metabolism_Homo sapiens_hsa002400.49392553
94Cell cycle_Homo sapiens_hsa041100.47803434
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46279332
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45071604
97Metabolic pathways_Homo sapiens_hsa011000.45064974
98Colorectal cancer_Homo sapiens_hsa052100.44010973
99Peroxisome_Homo sapiens_hsa041460.43996093
100Phenylalanine metabolism_Homo sapiens_hsa003600.43986355

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