MAGEH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the non-CT (non cancer/testis) subgroup of the melanoma-associated antigen (MAGE) superfamily. The encoded protein is likely associated with apoptosis, cell cycle arrest, growth inhibition or cell differentiation. The protein may be involved in the atRA (all-trans retinoic acid) signaling through the STAT1-alpha (signal transducer and activator of transcription 1-alpha) pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)8.70456468
2doxorubicin metabolic process (GO:0044598)8.70456468
3daunorubicin metabolic process (GO:0044597)8.70456468
4response to dietary excess (GO:0002021)5.57369625
5somite rostral/caudal axis specification (GO:0032525)5.54460557
6aminoglycoside antibiotic metabolic process (GO:0030647)5.54428348
7pyrimidine nucleobase catabolic process (GO:0006208)5.50109539
8phenol-containing compound catabolic process (GO:0019336)5.27434460
9maintenance of protein location in nucleus (GO:0051457)5.07904750
10presynaptic membrane assembly (GO:0097105)4.68607149
11neuron cell-cell adhesion (GO:0007158)4.60110766
12negative regulation of epidermis development (GO:0045683)4.57281145
13postsynaptic membrane organization (GO:0001941)4.55173648
14regulation of mammary gland epithelial cell proliferation (GO:0033599)4.45571990
15nucleobase catabolic process (GO:0046113)4.42239336
16regulation of response to osmotic stress (GO:0047484)4.36203943
17presynaptic membrane organization (GO:0097090)4.35107243
18regulation of cilium movement (GO:0003352)4.27003731
19negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.24551848
20proline transport (GO:0015824)4.21334232
21histone H4-K8 acetylation (GO:0043982)4.18977975
22histone H4-K5 acetylation (GO:0043981)4.18977975
23histone H4-K12 acetylation (GO:0043983)4.18557518
24muscle organ morphogenesis (GO:0048644)4.15944456
25negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.08143539
26maintenance of protein localization in organelle (GO:0072595)3.99489996
27primitive streak formation (GO:0090009)3.97061740
28synaptic vesicle maturation (GO:0016188)3.96179822
29vocalization behavior (GO:0071625)3.93371577
30hormone catabolic process (GO:0042447)3.85508154
31positive regulation of mitochondrial fission (GO:0090141)3.81335396
32protein localization to synapse (GO:0035418)3.80291958
33calcium-mediated signaling using intracellular calcium source (GO:0035584)3.76940512
34neuronal action potential propagation (GO:0019227)3.75671223
35protein localization to cilium (GO:0061512)3.73940731
36Golgi transport vesicle coating (GO:0048200)3.70095445
37COPI coating of Golgi vesicle (GO:0048205)3.70095445
38regulation of telomere maintenance via telomerase (GO:0032210)3.69063928
39regulation of microtubule-based movement (GO:0060632)3.68314564
40regulation of MHC class I biosynthetic process (GO:0045343)3.65175172
41auditory behavior (GO:0031223)3.58677489
42negative regulation of epidermal cell differentiation (GO:0045605)3.58000263
43neurotransmitter-gated ion channel clustering (GO:0072578)3.53955299
44negative regulation of telomerase activity (GO:0051974)3.53660808
45negative regulation of cell cycle G2/M phase transition (GO:1902750)3.51942812
46axonal fasciculation (GO:0007413)3.51873130
47synaptic vesicle exocytosis (GO:0016079)3.50855152
48signal transduction involved in regulation of gene expression (GO:0023019)3.50390033
49cytidine deamination (GO:0009972)3.47840318
50cytidine metabolic process (GO:0046087)3.47840318
51cytidine catabolic process (GO:0006216)3.47840318
52regulation of apoptotic process involved in morphogenesis (GO:1902337)3.47504659
53notochord development (GO:0030903)3.47078792
54GDP-mannose metabolic process (GO:0019673)3.45258295
55rRNA transcription (GO:0009303)3.44527274
56synapse assembly (GO:0007416)3.42331945
57intestinal epithelial cell development (GO:0060576)3.37229941
58coenzyme catabolic process (GO:0009109)3.36957126
59regulation of nuclear cell cycle DNA replication (GO:0033262)3.35195694
60protein polyglutamylation (GO:0018095)3.34609465
61regulation of short-term neuronal synaptic plasticity (GO:0048172)3.33656461
62dendritic spine morphogenesis (GO:0060997)3.32213491
63nucleoside transmembrane transport (GO:1901642)3.30920526
64cell fate commitment involved in formation of primary germ layer (GO:0060795)3.30192976
65sequestering of actin monomers (GO:0042989)3.28136574
66transmission of nerve impulse (GO:0019226)3.27231628
67quinone metabolic process (GO:1901661)3.26428121
68regulation of synapse structural plasticity (GO:0051823)3.25807751
69gamma-aminobutyric acid transport (GO:0015812)3.24507546
70synaptic transmission, glutamatergic (GO:0035249)3.23852096
71cardiovascular system development (GO:0072358)3.22145725
72ionotropic glutamate receptor signaling pathway (GO:0035235)3.21830346
73nonmotile primary cilium assembly (GO:0035058)3.21733478
74behavioral response to nicotine (GO:0035095)3.21571953
75neuron recognition (GO:0008038)3.20378102
76branching involved in mammary gland duct morphogenesis (GO:0060444)3.20171126
77G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.18039646
78calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.17344165
79glutamate secretion (GO:0014047)3.17020923
80regulation of synaptic vesicle exocytosis (GO:2000300)3.15973579
81negative regulation of synaptic transmission, GABAergic (GO:0032229)3.15761135
82establishment of mitochondrion localization (GO:0051654)3.12736209
83retinal ganglion cell axon guidance (GO:0031290)3.11944870
84melanosome transport (GO:0032402)3.11060333
85glandular epithelial cell differentiation (GO:0002067)3.10495660
86negative regulation of smoothened signaling pathway (GO:0045879)3.10232914
87establishment of melanosome localization (GO:0032401)3.08940054
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.08236899
89positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.07021211
90microtubule severing (GO:0051013)3.06791341
91negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.06442045
92mechanosensory behavior (GO:0007638)3.05724212
93cullin deneddylation (GO:0010388)3.05577683
94histone H4-K16 acetylation (GO:0043984)3.04720006
95regulation of glucose import in response to insulin stimulus (GO:2001273)3.03820531
96glutamate receptor signaling pathway (GO:0007215)3.03270418
97positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.03225357
98regulation of Golgi to plasma membrane protein transport (GO:0042996)3.01690488
99neurotransmitter secretion (GO:0007269)3.00701310
100regulation of autophagic vacuole assembly (GO:2000785)2.99604518
101positive regulation of synapse assembly (GO:0051965)2.99514493
102mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.98358668
103pigment granule transport (GO:0051904)2.94985004
104regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.94338867
105establishment of pigment granule localization (GO:0051905)2.93691798
106membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.93346391
107detection of temperature stimulus (GO:0016048)2.92883964
108response to auditory stimulus (GO:0010996)2.92674217
109negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91247950
110regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.90638356
111neuron fate determination (GO:0048664)2.87924177
112regulation of synaptic vesicle transport (GO:1902803)2.87832550
113neurofilament cytoskeleton organization (GO:0060052)2.87712045
114neuron-neuron synaptic transmission (GO:0007270)2.87673121
115inner ear receptor cell development (GO:0060119)2.87472059
116cellular modified amino acid catabolic process (GO:0042219)2.87113792
117protein maturation by protein folding (GO:0022417)2.86763927
118glycosphingolipid biosynthetic process (GO:0006688)2.86537397
119mitochondrion distribution (GO:0048311)2.85996686
120intraciliary transport (GO:0042073)2.85277014
121C4-dicarboxylate transport (GO:0015740)2.85107614
122negative regulation of potassium ion transmembrane transport (GO:1901380)2.81085298
123axon ensheathment in central nervous system (GO:0032291)2.78619020
124central nervous system myelination (GO:0022010)2.78619020
125negative regulation of oligodendrocyte differentiation (GO:0048715)2.77572455
126neuromuscular synaptic transmission (GO:0007274)2.76171227
127regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.76142709
128intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.74520964
129peptide hormone processing (GO:0016486)2.73904217
130anterior/posterior axis specification (GO:0009948)2.73213863
131thyroid hormone generation (GO:0006590)2.72855143
132epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72598561
133positive regulation of histone deacetylation (GO:0031065)2.69776326
134regulation of synaptic transmission, glutamatergic (GO:0051966)2.69446700
135bone trabecula formation (GO:0060346)2.68760434
136adaptation of signaling pathway (GO:0023058)2.68224623
137epithelial cilium movement (GO:0003351)2.68008153
138positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.67398077
139mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.67258388
140response to pheromone (GO:0019236)2.66158029
141tachykinin receptor signaling pathway (GO:0007217)2.65996193
142embryonic axis specification (GO:0000578)2.65667255
143synapse organization (GO:0050808)2.65218833
144endocrine pancreas development (GO:0031018)2.64989229
145positive regulation of amino acid transport (GO:0051957)2.62899592
146pyrimidine ribonucleoside catabolic process (GO:0046133)2.62202283
147regulation of type B pancreatic cell apoptotic process (GO:2000674)2.61713760
148cilium morphogenesis (GO:0060271)2.61506858
149synaptic transmission, cholinergic (GO:0007271)2.61357400
150negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.61107275
151ventricular system development (GO:0021591)2.60451301
152protein complex biogenesis (GO:0070271)2.59288404
153locomotory exploration behavior (GO:0035641)2.59094112
154positive regulation of TOR signaling (GO:0032008)2.58875548
155melanosome localization (GO:0032400)2.58525318
156platelet dense granule organization (GO:0060155)2.57998500
157short-term memory (GO:0007614)2.57302314
158negative regulation of axon extension (GO:0030517)2.57270940
159protein deneddylation (GO:0000338)2.55901714
160negative regulation of bone resorption (GO:0045779)2.55159271
161regulation of development, heterochronic (GO:0040034)2.54470713
162positive regulation of protein deacetylation (GO:0090312)2.54299854
163adult walking behavior (GO:0007628)2.53486351
164regulation of neurotransmitter levels (GO:0001505)2.53320521
165protein-cofactor linkage (GO:0018065)2.52738193
166regulation of transcription involved in cell fate commitment (GO:0060850)2.52671805
167mitochondrial respiratory chain complex I assembly (GO:0032981)2.51393882
168NADH dehydrogenase complex assembly (GO:0010257)2.51393882
169mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.51393882
170body morphogenesis (GO:0010171)2.50551791
171regulation of feeding behavior (GO:0060259)2.49963519
172nucleoside transport (GO:0015858)2.49948380
173vitamin A metabolic process (GO:0006776)2.49907215
174positive regulation of gluconeogenesis (GO:0045722)2.49871340
175rRNA methylation (GO:0031167)2.49804510
176exploration behavior (GO:0035640)2.49694723
177establishment of protein localization to mitochondrial membrane (GO:0090151)2.49528380
178chondroitin sulfate catabolic process (GO:0030207)2.48843101
179regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.48541198
180energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.47758506
181ATP hydrolysis coupled proton transport (GO:0015991)2.47758506
182regulation of vacuole organization (GO:0044088)2.47681921
183negative regulation of telomere maintenance (GO:0032205)2.47333985
184stress granule assembly (GO:0034063)2.47052876
185behavioral fear response (GO:0001662)2.45751977
186behavioral defense response (GO:0002209)2.45751977
187energy coupled proton transport, down electrochemical gradient (GO:0015985)2.45461959
188ATP synthesis coupled proton transport (GO:0015986)2.45461959
189regulation of timing of cell differentiation (GO:0048505)2.44731903
190startle response (GO:0001964)2.40590987
191neuronal action potential (GO:0019228)2.40464059
192regulation of vesicle fusion (GO:0031338)2.39569257
193establishment of synaptic vesicle localization (GO:0097480)2.39565665
194synaptic vesicle transport (GO:0048489)2.39565665

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.94647341
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.94647341
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.94647341
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.34559958
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.75872736
6GBX2_23144817_ChIP-Seq_PC3_Human3.11266895
7ZNF274_21170338_ChIP-Seq_K562_Hela2.79036292
8* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.75654837
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.70531428
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.62028597
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.61895894
12SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.57014715
13NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.54451188
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23729355
15TAF15_26573619_Chip-Seq_HEK293_Human2.19058986
16TCF3_18692474_ChIP-Seq_MESCs_Mouse2.15354581
17EZH2_22144423_ChIP-Seq_EOC_Human2.05774514
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05489515
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04252598
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03566235
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.98104993
22ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.95648426
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94935282
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.94196280
25NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.93778006
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.90995053
27TCF3_18692474_ChIP-Seq_MEFs_Mouse1.88338108
28ZFP281_18757296_ChIP-ChIP_E14_Mouse1.86631719
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80997503
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.80328754
31P300_19829295_ChIP-Seq_ESCs_Human1.78809332
32REST_21632747_ChIP-Seq_MESCs_Mouse1.77363328
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77097800
34IRF1_19129219_ChIP-ChIP_H3396_Human1.74114161
35SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73068771
36IGF1R_20145208_ChIP-Seq_DFB_Human1.71047073
37FUS_26573619_Chip-Seq_HEK293_Human1.70617563
38RNF2_27304074_Chip-Seq_NSC_Mouse1.65277048
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63569270
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.63380629
41TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.63369917
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63191855
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62021952
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62021952
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61719365
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.61515274
47NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.60360083
48REST_18959480_ChIP-ChIP_MESCs_Mouse1.60219354
49* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.59489493
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55958131
51SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.55892918
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55395403
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54503805
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54141650
55SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53952732
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53771281
57POU5F1_16518401_ChIP-PET_MESCs_Mouse1.51471995
58RING1B_27294783_Chip-Seq_NPCs_Mouse1.51401316
59JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50613926
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.48585939
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.47662883
62ZFP281_27345836_Chip-Seq_ESCs_Mouse1.45972939
63SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.45618731
64RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.45399663
65EWS_26573619_Chip-Seq_HEK293_Human1.42029179
66RARB_27405468_Chip-Seq_BRAIN_Mouse1.40788027
67* SMAD4_21799915_ChIP-Seq_A2780_Human1.40144157
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39061017
69FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.38349951
70PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.37571135
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37406724
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.35699421
73JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34395824
74CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.34354249
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.33942663
76GABP_17652178_ChIP-ChIP_JURKAT_Human1.33833869
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33464346
78TP53_20018659_ChIP-ChIP_R1E_Mouse1.32888331
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32869146
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32648250
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32293130
82WT1_19549856_ChIP-ChIP_CCG9911_Human1.30547425
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29131553
84AR_25329375_ChIP-Seq_VCAP_Human1.28558258
85TBX3_20139965_ChIP-Seq_MESCs_Mouse1.27483973
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25026083
87SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.24133501
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23725809
89TBX3_20139965_ChIP-Seq_ESCs_Mouse1.23366929
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22529566
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21761755
92CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21074461
93SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20983264
94NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20126234
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19807607
96NANOG_16518401_ChIP-PET_MESCs_Mouse1.19045086
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18686278
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18256089
99EZH2_27294783_Chip-Seq_ESCs_Mouse1.18211887
100FLI1_27457419_Chip-Seq_LIVER_Mouse1.18161113
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17808362
102MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14733100
103TP53_22573176_ChIP-Seq_HFKS_Human1.14394975
104TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11342417
105EED_16625203_ChIP-ChIP_MESCs_Mouse1.09734859
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09517371
107POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.09156218
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09142799
109CBP_20019798_ChIP-Seq_JUKART_Human1.09142799
110AR_21572438_ChIP-Seq_LNCaP_Human1.08808694
111RING1B_27294783_Chip-Seq_ESCs_Mouse1.08140826
112KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08123242
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07835884
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07835884
115NANOG_18555785_Chip-Seq_ESCs_Mouse1.07627814
116KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07052351
117BCAT_22108803_ChIP-Seq_LS180_Human1.06732379
118RUNX2_22187159_ChIP-Seq_PCA_Human1.05983024
119SOX3_22085726_ChIP-Seq_NPCs_Mouse1.05607580
120SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05216673
121ER_23166858_ChIP-Seq_MCF-7_Human1.05179551
122PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04525901
123KDM2B_26808549_Chip-Seq_K562_Human1.02881082
124SOX2_21211035_ChIP-Seq_LN229_Gbm1.01896325
125NANOG_16153702_ChIP-ChIP_HESCs_Human1.01267848
126EST1_17652178_ChIP-ChIP_JURKAT_Human1.01115798
127NANOG_18692474_ChIP-Seq_MESCs_Mouse1.00781170
128EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99764787
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99533545
130TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99527153
131SOX2_16153702_ChIP-ChIP_HESCs_Human0.99416266
132ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98607928
133* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98581761
134SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98486416
135HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98367575
136DROSHA_22980978_ChIP-Seq_HELA_Human0.98150024
137STAT3_23295773_ChIP-Seq_U87_Human0.97760270
138VDR_22108803_ChIP-Seq_LS180_Human0.96693948
139NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96520170
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96345208
141KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95935425
142CDX2_20551321_ChIP-Seq_CACO-2_Human0.95889457
143TAL1_26923725_Chip-Seq_HPCs_Mouse0.95316816
144POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94737641
145TCF4_23295773_ChIP-Seq_U87_Human0.94161360
146SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93817660
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92426667
148PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92203227
149JUN_21703547_ChIP-Seq_K562_Human0.91405274
150P53_22387025_ChIP-Seq_ESCs_Mouse0.90718615
151POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.89646045
152KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89253806
153TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87255892
154CBX2_27304074_Chip-Seq_ESCs_Mouse0.86925204
155HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86796165
156OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86301446
157TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.85988567
158SOX2_18555785_ChIP-Seq_MESCs_Mouse0.85341441
159SMC4_20622854_ChIP-Seq_HELA_Human0.85053880
160WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84990469
161SOX2_18692474_ChIP-Seq_MESCs_Mouse0.84724910
162STAT3_18555785_ChIP-Seq_MESCs_Mouse0.83466879
163CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82740398
164EOMES_21245162_ChIP-Seq_HESCs_Human0.82617305
165NANOG_18692474_ChIP-Seq_MEFs_Mouse0.81337284

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.25081688
2MP0006292_abnormal_olfactory_placode3.93497696
3MP0002822_catalepsy3.30556503
4MP0004264_abnormal_extraembryonic_tissu3.28228954
5MP0004858_abnormal_nervous_system3.25856368
6MP0003283_abnormal_digestive_organ3.13393292
7MP0001529_abnormal_vocalization2.91734227
8MP0003011_delayed_dark_adaptation2.91678201
9MP0003183_abnormal_peptide_metabolism2.86666660
10MP0000678_abnormal_parathyroid_gland2.84631091
11MP0004043_abnormal_pH_regulation2.83099404
12MP0003890_abnormal_embryonic-extraembry2.82679101
13MP0005499_abnormal_olfactory_system2.69283516
14MP0005394_taste/olfaction_phenotype2.69283516
15MP0002909_abnormal_adrenal_gland2.67678413
16MP0002254_reproductive_system_inflammat2.63714110
17MP0003121_genomic_imprinting2.48385093
18MP0003136_yellow_coat_color2.44456057
19MP0005257_abnormal_intraocular_pressure2.41584258
20MP0005423_abnormal_somatic_nervous2.32492647
21MP0001968_abnormal_touch/_nociception2.32147234
22MP0002653_abnormal_ependyma_morphology2.28865529
23MP0001984_abnormal_olfaction2.27152399
24MP0004270_analgesia2.25981575
25MP0002102_abnormal_ear_morphology2.15741414
26MP0002735_abnormal_chemical_nociception2.05677261
27MP0002736_abnormal_nociception_after2.04046011
28MP0002638_abnormal_pupillary_reflex2.00567961
29MP0002877_abnormal_melanocyte_morpholog1.83617465
30MP0003787_abnormal_imprinting1.73656943
31MP0008961_abnormal_basal_metabolism1.73182745
32MP0001905_abnormal_dopamine_level1.68298323
33MP0005075_abnormal_melanosome_morpholog1.67722686
34MP0003119_abnormal_digestive_system1.60351947
35MP0009780_abnormal_chondrocyte_physiolo1.59137888
36MP0003938_abnormal_ear_development1.57324731
37MP0006072_abnormal_retinal_apoptosis1.56793075
38MP0002332_abnormal_exercise_endurance1.56302944
39MP0000631_abnormal_neuroendocrine_gland1.55499485
40MP0000049_abnormal_middle_ear1.55213713
41MP0005551_abnormal_eye_electrophysiolog1.53304987
42MP0002067_abnormal_sensory_capabilities1.51757396
43MP0005379_endocrine/exocrine_gland_phen1.50510389
44MP0000013_abnormal_adipose_tissue1.46434463
45MP0003123_paternal_imprinting1.45840849
46MP0005386_behavior/neurological_phenoty1.39524131
47MP0004924_abnormal_behavior1.39524131
48MP0002572_abnormal_emotion/affect_behav1.36241825
49MP0002734_abnormal_mechanical_nocicepti1.35932853
50MP0002733_abnormal_thermal_nociception1.34698800
51MP0004859_abnormal_synaptic_plasticity1.33321112
52MP0002751_abnormal_autonomic_nervous1.32399272
53MP0002127_abnormal_cardiovascular_syste1.32074859
54MP0001188_hyperpigmentation1.29425146
55MP0000955_abnormal_spinal_cord1.26719181
56MP0008789_abnormal_olfactory_epithelium1.26415219
57MP0006035_abnormal_mitochondrial_morpho1.25845832
58MP0003635_abnormal_synaptic_transmissio1.25209284
59MP0004811_abnormal_neuron_physiology1.23245167
60MP0000428_abnormal_craniofacial_morphol1.19951130
61MP0005171_absent_coat_pigmentation1.19357133
62MP0005253_abnormal_eye_physiology1.18816385
63MP0001944_abnormal_pancreas_morphology1.17093676
64MP0005248_abnormal_Harderian_gland1.16759599
65MP0000566_synostosis1.16383774
66MP0000026_abnormal_inner_ear1.16052756
67MP0005084_abnormal_gallbladder_morpholo1.15254038
68MP0001486_abnormal_startle_reflex1.15183021
69MP0002233_abnormal_nose_morphology1.15056572
70MP0001502_abnormal_circadian_rhythm1.14068163
71MP0002063_abnormal_learning/memory/cond1.13999604
72MP0008569_lethality_at_weaning1.13936081
73MP0000778_abnormal_nervous_system1.12007139
74MP0002184_abnormal_innervation1.11259226
75MP0001501_abnormal_sleep_pattern1.11139023
76MP0000372_irregular_coat_pigmentation1.09738983
77MP0002066_abnormal_motor_capabilities/c1.08155948
78MP0001270_distended_abdomen1.08044443
79MP0000762_abnormal_tongue_morphology1.07769428
80MP0004133_heterotaxia1.07625105
81MP0005646_abnormal_pituitary_gland1.05425771
82MP0002693_abnormal_pancreas_physiology1.03776151
83MP0002932_abnormal_joint_morphology1.03193812
84MP0002152_abnormal_brain_morphology1.02613991
85MP0001986_abnormal_taste_sensitivity1.02032911
86MP0008877_abnormal_DNA_methylation1.01772453
87MP0010030_abnormal_orbit_morphology1.01631647
88MP0005645_abnormal_hypothalamus_physiol1.00536109
89MP0004885_abnormal_endolymph1.00019538
90MP0003755_abnormal_palate_morphology0.99640971
91MP0003137_abnormal_impulse_conducting0.99532395
92MP0002116_abnormal_craniofacial_bone0.97776105
93MP0001348_abnormal_lacrimal_gland0.97119853
94MP0001293_anophthalmia0.97093118
95MP0003935_abnormal_craniofacial_develop0.96787071
96MP0001849_ear_inflammation0.96666656
97MP0003633_abnormal_nervous_system0.96446076
98MP0001440_abnormal_grooming_behavior0.96366462
99MP0002928_abnormal_bile_duct0.95918094
100MP0002064_seizures0.94611777
101MP0001963_abnormal_hearing_physiology0.94139921
102MP0001970_abnormal_pain_threshold0.93720593
103MP0002277_abnormal_respiratory_mucosa0.93231932
104MP0002069_abnormal_eating/drinking_beha0.91814679
105MP0002272_abnormal_nervous_system0.90989008
106MP0002938_white_spotting0.89920478
107MP0005391_vision/eye_phenotype0.89762156
108MP0004147_increased_porphyrin_level0.89142321
109MP0002114_abnormal_axial_skeleton0.89123371
110MP0005187_abnormal_penis_morphology0.88951963
111MP0002557_abnormal_social/conspecific_i0.87844020
112MP0004085_abnormal_heartbeat0.87611198
113MP0003634_abnormal_glial_cell0.86513870
114MP0002229_neurodegeneration0.85904640
115MP0001485_abnormal_pinna_reflex0.85634113
116MP0003942_abnormal_urinary_system0.84714454
117MP0004742_abnormal_vestibular_system0.84422422
118MP0002163_abnormal_gland_morphology0.83254302
119MP0009046_muscle_twitch0.83199550
120MP0002882_abnormal_neuron_morphology0.81174791
121MP0002752_abnormal_somatic_nervous0.80215074
122MP0003631_nervous_system_phenotype0.79012277
123MP0002837_dystrophic_cardiac_calcinosis0.78599218
124MP0003329_amyloid_beta_deposits0.78364355
125MP0005195_abnormal_posterior_eye0.77986772
126MP0002092_abnormal_eye_morphology0.77263505
127MP0003861_abnormal_nervous_system0.76820224
128MP0001177_atelectasis0.76655340
129MP0002078_abnormal_glucose_homeostasis0.75638489
130MP0008995_early_reproductive_senescence0.75308251
131MP0005508_abnormal_skeleton_morphology0.74757006
132MP0006276_abnormal_autonomic_nervous0.73624846
133MP0004142_abnormal_muscle_tone0.73610889
134MP0000163_abnormal_cartilage_morphology0.73565977
135MP0010386_abnormal_urinary_bladder0.72991706
136MP0000432_abnormal_head_morphology0.72716785
137MP0002090_abnormal_vision0.72426549
138MP0009745_abnormal_behavioral_response0.72220401
139MP0001299_abnormal_eye_distance/0.70939055
140MP0001672_abnormal_embryogenesis/_devel0.69467059
141MP0005380_embryogenesis_phenotype0.69467059
142MP0004145_abnormal_muscle_electrophysio0.69161521
143MP0005367_renal/urinary_system_phenotyp0.68617690
144MP0000516_abnormal_urinary_system0.68617690
145MP0003880_abnormal_central_pattern0.67982356
146MP0002081_perinatal_lethality0.66439597
147MP0002249_abnormal_larynx_morphology0.66108424
148MP0002084_abnormal_developmental_patter0.64566693
149MP0002234_abnormal_pharynx_morphology0.64104265

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.33695477
2Hepatoblastoma (HP:0002884)5.98039452
3Hyperinsulinemic hypoglycemia (HP:0000825)5.82945271
4Hypochromic microcytic anemia (HP:0004840)4.62438624
5Myokymia (HP:0002411)4.58140783
6Focal motor seizures (HP:0011153)4.37233057
7Polyphagia (HP:0002591)4.28068162
8Abnormality of the lower motor neuron (HP:0002366)4.15406483
9Hypoplasia of the fovea (HP:0007750)3.92252623
10Aplasia/Hypoplasia of the fovea (HP:0008060)3.92252623
11Gait imbalance (HP:0002141)3.83464335
12Rib fusion (HP:0000902)3.61358758
13Bifid tongue (HP:0010297)3.60076145
14Medial flaring of the eyebrow (HP:0010747)3.59243459
15Limb dystonia (HP:0002451)3.51261739
16Multiple enchondromatosis (HP:0005701)3.46247640
17Congenital primary aphakia (HP:0007707)3.40203181
18Abnormality of the fovea (HP:0000493)3.33450263
19Nephrogenic diabetes insipidus (HP:0009806)3.20877064
20Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.18429164
21Focal seizures (HP:0007359)3.12222879
22Pancreatic islet-cell hyperplasia (HP:0004510)3.09370846
23Amyotrophic lateral sclerosis (HP:0007354)3.02802235
24Neoplasm of the heart (HP:0100544)3.00360693
25Hyperventilation (HP:0002883)2.96750262
26True hermaphroditism (HP:0010459)2.95805388
27Nephronophthisis (HP:0000090)2.92915483
28Pancreatic fibrosis (HP:0100732)2.91596406
29Pancreatic cysts (HP:0001737)2.88812595
30Abnormality of the labia minora (HP:0012880)2.86446784
31Acute necrotizing encephalopathy (HP:0006965)2.85661639
32Ependymoma (HP:0002888)2.83698935
33Abnormal eating behavior (HP:0100738)2.83663046
34Vaginal atresia (HP:0000148)2.76623142
35Nephroblastoma (Wilms tumor) (HP:0002667)2.76605463
36Hemiparesis (HP:0001269)2.75044405
37Genital tract atresia (HP:0001827)2.74539459
38Abnormality of the salivary glands (HP:0010286)2.69432975
39Abnormality of calcium-phosphate metabolism (HP:0100530)2.69160251
40Molar tooth sign on MRI (HP:0002419)2.65055004
41Abnormality of midbrain morphology (HP:0002418)2.65055004
42Poor suck (HP:0002033)2.64091886
43Progressive macrocephaly (HP:0004481)2.58813600
44Embryonal renal neoplasm (HP:0011794)2.58785261
45Specific learning disability (HP:0001328)2.57422131
46Testicular atrophy (HP:0000029)2.56549595
47Retinal dysplasia (HP:0007973)2.55374939
48Neoplasm of striated muscle (HP:0009728)2.54648616
49Amblyopia (HP:0000646)2.51546956
50Abnormal mitochondria in muscle tissue (HP:0008316)2.51474450
51Mitochondrial inheritance (HP:0001427)2.48615987
52Abnormality of endocrine pancreas physiology (HP:0012093)2.48243057
53Abnormality of the pancreatic islet cells (HP:0006476)2.48243057
54Type II lissencephaly (HP:0007260)2.47393295
55Generalized hypotonia (HP:0001290)2.47246166
56Hypsarrhythmia (HP:0002521)2.43700574
57Symptomatic seizures (HP:0011145)2.43340558
58Hypoglycemic seizures (HP:0002173)2.42558237
59Epileptic encephalopathy (HP:0200134)2.41465900
60Aplasia/Hypoplasia of the macula (HP:0008059)2.41209031
61Progressive cerebellar ataxia (HP:0002073)2.40829072
62Epileptiform EEG discharges (HP:0011182)2.40328011
63EEG with generalized epileptiform discharges (HP:0011198)2.39068812
64Lissencephaly (HP:0001339)2.37833409
65Acute encephalopathy (HP:0006846)2.37489895
66Horizontal nystagmus (HP:0000666)2.37449731
67Split foot (HP:0001839)2.33728898
68Generalized tonic-clonic seizures (HP:0002069)2.33453554
69Aplasia/Hypoplasia affecting the retina (HP:0008061)2.32666908
70Fused cervical vertebrae (HP:0002949)2.31741545
71Inability to walk (HP:0002540)2.31034476
72Partial duplication of thumb phalanx (HP:0009944)2.30674405
73Ragged-red muscle fibers (HP:0003200)2.30451619
74Septo-optic dysplasia (HP:0100842)2.28001225
75Resting tremor (HP:0002322)2.26067367
76Anomalous pulmonary venous return (HP:0010772)2.26028255
77Renal duplication (HP:0000075)2.25734200
78Abnormality of the renal medulla (HP:0100957)2.25423570
79Spastic tetraplegia (HP:0002510)2.24414466
80Methylmalonic aciduria (HP:0012120)2.24036040
81Osteomalacia (HP:0002749)2.23167517
82Shawl scrotum (HP:0000049)2.22629491
83Optic nerve hypoplasia (HP:0000609)2.21598918
84Absence seizures (HP:0002121)2.20224328
85Abnormality of the astrocytes (HP:0100707)2.18463181
86Astrocytoma (HP:0009592)2.18463181
87Action tremor (HP:0002345)2.17893405
88Excessive salivation (HP:0003781)2.17297876
89Short tibia (HP:0005736)2.17061754
90Tetraplegia (HP:0002445)2.16835861
91Postaxial hand polydactyly (HP:0001162)2.11876497
92Poor coordination (HP:0002370)2.11268561
93Failure to thrive in infancy (HP:0001531)2.10837518
94Rhabdomyosarcoma (HP:0002859)2.07429506
95Abnormality of small intestinal villus morphology (HP:0011472)2.06785834
96Villous atrophy (HP:0011473)2.06785834
97Esotropia (HP:0000565)2.05988918
98Methylmalonic acidemia (HP:0002912)2.05730365
99Increased CSF lactate (HP:0002490)2.03875508
100Ketoacidosis (HP:0001993)2.03239428
101Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.03029694
102Hepatocellular necrosis (HP:0001404)2.01723080
103Progressive inability to walk (HP:0002505)2.01328595
104Progressive muscle weakness (HP:0003323)2.01312155
105Upper limb muscle weakness (HP:0003484)2.00704309
106Partial duplication of the phalanx of hand (HP:0009999)1.99469661
107Abnormality of the pubic bones (HP:0003172)1.99441193
108Pachygyria (HP:0001302)1.99351836
109Aplasia/Hypoplasia of the tibia (HP:0005772)1.99174709
110Abnormality of liposaccharide metabolism (HP:0010968)1.96959389
111Abnormality of glycosphingolipid metabolism (HP:0004343)1.96959389
112Abnormality of glycolipid metabolism (HP:0010969)1.96959389
113Ectopic anus (HP:0004397)1.96473164
114Sensory axonal neuropathy (HP:0003390)1.96454150
115Abnormality of chromosome segregation (HP:0002916)1.95373075
116Abnormality of the intrinsic pathway (HP:0010989)1.95042675
117Abnormality of the musculature of the hand (HP:0001421)1.94367562
118Absent speech (HP:0001344)1.93990323
119Rectovaginal fistula (HP:0000143)1.93790557
120Rectal fistula (HP:0100590)1.93790557
121Occipital encephalocele (HP:0002085)1.93695258
122Hand muscle atrophy (HP:0009130)1.92718268
123Preauricular pit (HP:0004467)1.92710841
124Periauricular skin pits (HP:0100277)1.92710841
125Hepatic necrosis (HP:0002605)1.91608676
126Malignant neoplasm of the central nervous system (HP:0100836)1.91244734
127Atonic seizures (HP:0010819)1.90997430
128Scrotal hypoplasia (HP:0000046)1.90859096
129Nasolacrimal duct obstruction (HP:0000579)1.89718156
130Abnormality of the pulmonary veins (HP:0011718)1.89370408
131Cortical visual impairment (HP:0100704)1.88552687
132Intestinal atresia (HP:0011100)1.88387192
133Large for gestational age (HP:0001520)1.88150696
134Missing ribs (HP:0000921)1.88102451
135Sclerocornea (HP:0000647)1.87920603
136Febrile seizures (HP:0002373)1.87056044
137Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86665434
138Skin nodule (HP:0200036)1.86599405
139Cystic liver disease (HP:0006706)1.86038687
140Short humerus (HP:0005792)1.85963169
141Anencephaly (HP:0002323)1.85477286
142Abnormal cartilage morphology (HP:0002763)1.85357591
143Narrow forehead (HP:0000341)1.84415930
144Status epilepticus (HP:0002133)1.83955019
145Abnormality of the corticospinal tract (HP:0002492)1.83545618
146Dysautonomia (HP:0002459)1.83505525
147Broad foot (HP:0001769)1.82654417
148Decreased testicular size (HP:0008734)1.81747221
149Lipid accumulation in hepatocytes (HP:0006561)1.81376199
150Humeroradial synostosis (HP:0003041)1.81187370
151Synostosis involving the elbow (HP:0003938)1.81187370
152Cortical dysplasia (HP:0002539)1.81047883
153Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.80563319
154Growth hormone deficiency (HP:0000824)1.80434931
155Muscular hypotonia of the trunk (HP:0008936)1.80239748
156Abnormal hair whorl (HP:0010721)1.80057671
157Sleep apnea (HP:0010535)1.79759137
158Atrophy/Degeneration involving motor neurons (HP:0007373)1.79568927
159Agitation (HP:0000713)1.79548856
160Aplasia/hypoplasia of the humerus (HP:0006507)1.78312360
161Morphological abnormality of the pyramidal tract (HP:0002062)1.78176865
162Aplasia/Hypoplasia of the lens (HP:0008063)1.77819217
163Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.77753457
164Aplasia/Hypoplasia of the brainstem (HP:0007362)1.77407514
165Hypoplasia of the brainstem (HP:0002365)1.77407514
166Oligodactyly (hands) (HP:0001180)1.76960706
167Abnormal lung lobation (HP:0002101)1.76438688
168Broad-based gait (HP:0002136)1.76070416
169Hyperglycinemia (HP:0002154)1.76005250
170Generalized myoclonic seizures (HP:0002123)1.75410989
171Optic disc pallor (HP:0000543)1.75275524
172Mutism (HP:0002300)1.75098609
173Aplasia/Hypoplasia of the sternum (HP:0006714)1.74415966
174Degeneration of the lateral corticospinal tracts (HP:0002314)1.74324464
175Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.74324464
176Open mouth (HP:0000194)1.74141274
177Gout (HP:0001997)1.74043599
178Preauricular skin tag (HP:0000384)1.73597820
179Vaginal fistula (HP:0004320)1.73284417
180Dialeptic seizures (HP:0011146)1.73219655
181Skin pits (HP:0100276)1.71072840
182Visual hallucinations (HP:0002367)1.69579130
183Macroorchidism (HP:0000053)1.69333644
184Mildly elevated creatine phosphokinase (HP:0008180)1.68226391
185Broad alveolar ridges (HP:0000187)1.67623468
186Abnormality of the lacrimal duct (HP:0011481)1.67346660
187Drooling (HP:0002307)1.67073521

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.89278812
2GRK55.13880614
3ERN13.91524744
4MAP4K23.25510381
5NTRK13.01137658
6GRK62.83622671
7TYRO32.75157040
8ADRBK22.68812360
9INSRR2.54733661
10GRK12.36914358
11BCKDK2.32660543
12WNK12.27577627
13MAPK152.25317452
14HIPK22.18258085
15GRK72.15479285
16MAPK72.05503013
17NTRK32.05158091
18PRKD32.03179959
19AKT31.94829346
20PINK11.91550192
21TRIM281.84786847
22CSNK1G21.83747035
23WNK31.83580279
24PNCK1.80017415
25CSNK1G31.71505406
26MARK11.71031965
27MATK1.64325716
28PLK21.62841851
29MOS1.62487734
30CSF1R1.60779617
31MAP2K41.50830456
32CSNK1G11.48635821
33PASK1.48592251
34MARK21.48278683
35TGFBR21.47055481
36EPHA31.42026054
37CSNK1A1L1.41826651
38UHMK11.37817110
39TNIK1.35112389
40PDGFRA1.32004399
41ADRBK11.26838519
42CDK191.24026619
43NTRK21.23631714
44DAPK21.22432816
45TTK1.21214447
46PAK31.15038043
47CAMK41.12353135
48MAP3K91.09563948
49EPHB21.07788702
50PRKG21.06830234
51DYRK31.01402756
52WNK40.98860114
53FRK0.97910711
54ERBB30.97753857
55FGFR20.96294208
56CAMK2A0.95638482
57TSSK60.94552220
58FGFR30.93339958
59BMPR1B0.90728170
60MAP3K20.90105121
61PTK20.87538459
62EPHA40.87051705
63PKN10.85984592
64CASK0.85026804
65DYRK20.84996108
66DYRK1A0.83198122
67MAPKAPK50.78981589
68CAMK2B0.78718388
69SGK4940.78673619
70SGK2230.78673619
71TIE10.78157942
72CCNB10.77026526
73PAK60.72608604
74CAMK10.72575412
75RPS6KA40.68813911
76PRKCG0.68633556
77PIM20.65873019
78CHEK20.65550458
79CAMK2G0.64943679
80PRKCI0.64685052
81PRKD20.64071423
82CDC42BPA0.63864317
83MAP3K40.63023897
84MAPK130.62713268
85EPHA20.62386085
86ARAF0.61983125
87VRK10.61619212
88ALK0.60869795
89PRKCZ0.60131865
90CAMKK20.60006401
91PRKCH0.59251928
92RPS6KA50.58890402
93OXSR10.57089769
94CAMK2D0.56851519
95CDK50.53767502
96IGF1R0.53309599
97CDK30.52494093
98CDK70.51964279
99TESK10.51384372
100MAPK120.50671497
101LATS20.50527758
102PAK40.48384088
103ZAK0.48092657
104PHKG20.47407315
105PHKG10.47407315
106KSR20.46337009
107MAPK100.45701344
108NUAK10.45122231
109PRKG10.45082170
110PRPF4B0.43959342
111MINK10.43401788
112ERBB20.43334682
113DYRK1B0.42672326
114CDK140.42512326
115CDK150.42162823
116MAP2K60.42028325
117STK100.40398336
118CDK180.40313850
119PRKACA0.39957757
120AKT20.39097036
121STK160.37819220
122FER0.37406458
123STK390.37136378
124TXK0.36947698
125MAP3K120.35580383
126CDK11A0.35149258
127CSK0.35012755
128TAOK10.34688860
129CSNK1E0.34434988
130PRKCA0.34386737
131MTOR0.33950234
132PRKACG0.33828477
133GSK3A0.33754467
134DDR20.33226170
135SGK20.33066133
136NME10.32996393
137MAP3K70.32039191
138CAMKK10.31984068
139BCR0.31983941
140RPS6KA30.31979966
141GSK3B0.30927100
142ERBB40.29621828
143PRKAA10.28375598
144MAP2K70.26522175
145PRKCE0.26466287
146MAPK140.26206578
147CHEK10.25927268
148INSR0.25661689
149KSR10.24311179
150LIMK10.24187760
151SIK20.23614572
152MAP3K10.23433739
153PLK10.23127143
154CSNK1A10.22616665

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.96264080
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.75022228
3Oxidative phosphorylation_Homo sapiens_hsa001903.32316342
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.91524775
5Vitamin B6 metabolism_Homo sapiens_hsa007502.87495308
6Parkinsons disease_Homo sapiens_hsa050122.76066601
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.56647784
8Insulin secretion_Homo sapiens_hsa049112.47659448
9Steroid biosynthesis_Homo sapiens_hsa001002.17074069
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14896321
11Phototransduction_Homo sapiens_hsa047442.13905313
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12312471
13Protein export_Homo sapiens_hsa030602.10568574
14Fructose and mannose metabolism_Homo sapiens_hsa000512.09897976
15GABAergic synapse_Homo sapiens_hsa047272.07795235
16Alzheimers disease_Homo sapiens_hsa050101.93964106
17Butanoate metabolism_Homo sapiens_hsa006501.91646732
18Taste transduction_Homo sapiens_hsa047421.88208200
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.86830597
20Galactose metabolism_Homo sapiens_hsa000521.84272941
21Propanoate metabolism_Homo sapiens_hsa006401.73676292
22Huntingtons disease_Homo sapiens_hsa050161.71272108
23Serotonergic synapse_Homo sapiens_hsa047261.69600150
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.68598464
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.66600934
26Glutamatergic synapse_Homo sapiens_hsa047241.65230016
27Long-term potentiation_Homo sapiens_hsa047201.50942468
28Synaptic vesicle cycle_Homo sapiens_hsa047211.45385252
29Cocaine addiction_Homo sapiens_hsa050301.43914266
30Dopaminergic synapse_Homo sapiens_hsa047281.39163227
31Vibrio cholerae infection_Homo sapiens_hsa051101.37940032
32Linoleic acid metabolism_Homo sapiens_hsa005911.36314374
33Circadian entrainment_Homo sapiens_hsa047131.36271369
34Amphetamine addiction_Homo sapiens_hsa050311.33979903
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32297735
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31445467
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28885924
38Long-term depression_Homo sapiens_hsa047301.26214420
39Arachidonic acid metabolism_Homo sapiens_hsa005901.26039187
40Nicotine addiction_Homo sapiens_hsa050331.24959847
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.24730611
42mTOR signaling pathway_Homo sapiens_hsa041501.23932795
43Type II diabetes mellitus_Homo sapiens_hsa049301.22135729
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20922730
45Hedgehog signaling pathway_Homo sapiens_hsa043401.20566689
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19319283
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18597247
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17631435
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16153547
50Peroxisome_Homo sapiens_hsa041461.11947008
51Thyroid cancer_Homo sapiens_hsa052161.04452488
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04418844
53Ovarian steroidogenesis_Homo sapiens_hsa049131.01410721
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00296555
55Morphine addiction_Homo sapiens_hsa050321.00180232
56Fatty acid elongation_Homo sapiens_hsa000620.99725063
57Glycosaminoglycan degradation_Homo sapiens_hsa005310.98699043
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.96551888
59Cholinergic synapse_Homo sapiens_hsa047250.96036639
60Sulfur metabolism_Homo sapiens_hsa009200.94659329
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.93911652
62Type I diabetes mellitus_Homo sapiens_hsa049400.93642200
63Nitrogen metabolism_Homo sapiens_hsa009100.93638498
64Salivary secretion_Homo sapiens_hsa049700.93200747
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92616263
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92333290
67cAMP signaling pathway_Homo sapiens_hsa040240.89780647
68Renin secretion_Homo sapiens_hsa049240.89086780
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86185149
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.84843420
71Gap junction_Homo sapiens_hsa045400.84166363
72Basal cell carcinoma_Homo sapiens_hsa052170.84075158
73beta-Alanine metabolism_Homo sapiens_hsa004100.83722979
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83721250
75GnRH signaling pathway_Homo sapiens_hsa049120.83413642
76Calcium signaling pathway_Homo sapiens_hsa040200.82721131
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81462889
78Wnt signaling pathway_Homo sapiens_hsa043100.81337289
79Melanogenesis_Homo sapiens_hsa049160.79381683
80Ether lipid metabolism_Homo sapiens_hsa005650.78573144
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78285547
82Fatty acid metabolism_Homo sapiens_hsa012120.78075670
83Olfactory transduction_Homo sapiens_hsa047400.77539344
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75923335
85Inositol phosphate metabolism_Homo sapiens_hsa005620.75802281
86Collecting duct acid secretion_Homo sapiens_hsa049660.74061158
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74023300
88RNA polymerase_Homo sapiens_hsa030200.72827766
89Regulation of autophagy_Homo sapiens_hsa041400.72146251
90Choline metabolism in cancer_Homo sapiens_hsa052310.70822661
91Axon guidance_Homo sapiens_hsa043600.67356997
92Oxytocin signaling pathway_Homo sapiens_hsa049210.66947314
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66424726
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64917882
95Other glycan degradation_Homo sapiens_hsa005110.64695689
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63262852
97Dorso-ventral axis formation_Homo sapiens_hsa043200.62895197
98Prion diseases_Homo sapiens_hsa050200.62557273
99Rap1 signaling pathway_Homo sapiens_hsa040150.61944096
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61879134
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61809256
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61264816
103Folate biosynthesis_Homo sapiens_hsa007900.60787321
104Estrogen signaling pathway_Homo sapiens_hsa049150.59981818
105Pancreatic secretion_Homo sapiens_hsa049720.59304901
106Ras signaling pathway_Homo sapiens_hsa040140.58187663
107Thyroid hormone synthesis_Homo sapiens_hsa049180.57050964
108Proteasome_Homo sapiens_hsa030500.56116479
109Metabolic pathways_Homo sapiens_hsa011000.53328653
110Circadian rhythm_Homo sapiens_hsa047100.53262164
111Hippo signaling pathway_Homo sapiens_hsa043900.52924295
112Gastric acid secretion_Homo sapiens_hsa049710.52785863
113Bladder cancer_Homo sapiens_hsa052190.52162339
114Pyruvate metabolism_Homo sapiens_hsa006200.51526067
115N-Glycan biosynthesis_Homo sapiens_hsa005100.51377262
116Arginine and proline metabolism_Homo sapiens_hsa003300.51303728
117Dilated cardiomyopathy_Homo sapiens_hsa054140.50305548
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.47949356
119Tryptophan metabolism_Homo sapiens_hsa003800.47929121
120ErbB signaling pathway_Homo sapiens_hsa040120.47542197
121Glucagon signaling pathway_Homo sapiens_hsa049220.47420856
122Basal transcription factors_Homo sapiens_hsa030220.46893715
123Glioma_Homo sapiens_hsa052140.46172583
124mRNA surveillance pathway_Homo sapiens_hsa030150.45694073
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45651791
126Protein digestion and absorption_Homo sapiens_hsa049740.45536186
127Alcoholism_Homo sapiens_hsa050340.45132299
128Cardiac muscle contraction_Homo sapiens_hsa042600.45073442
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44455630
130Lysosome_Homo sapiens_hsa041420.44186095
131Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44096480
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42834410
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41766309
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41382422
135AMPK signaling pathway_Homo sapiens_hsa041520.41312686
136Tight junction_Homo sapiens_hsa045300.40550145
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39959369
138Fatty acid biosynthesis_Homo sapiens_hsa000610.39568057
139Oocyte meiosis_Homo sapiens_hsa041140.38583692
140RNA degradation_Homo sapiens_hsa030180.36098275
141Selenocompound metabolism_Homo sapiens_hsa004500.32648616
1422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31684277
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30330360
144Sulfur relay system_Homo sapiens_hsa041220.28370517
145Chemical carcinogenesis_Homo sapiens_hsa052040.27964925
146Cysteine and methionine metabolism_Homo sapiens_hsa002700.27186581
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26519543
148Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25264021
149Purine metabolism_Homo sapiens_hsa002300.24374306

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