MAGEL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.52416018
2axonal fasciculation (GO:0007413)6.53224904
3forebrain neuron differentiation (GO:0021879)6.04667863
4neuron recognition (GO:0008038)5.96930659
5nucleobase catabolic process (GO:0046113)5.86970727
6urogenital system development (GO:0001655)5.82646666
7positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.97023610
8postsynaptic membrane organization (GO:0001941)4.69446599
9negative regulation of microtubule polymerization (GO:0031115)4.52266730
10negative regulation of axon extension involved in axon guidance (GO:0048843)4.52162161
11positive regulation of mitochondrial fission (GO:0090141)4.50138036
12barbed-end actin filament capping (GO:0051016)4.41208319
13establishment of mitochondrion localization (GO:0051654)4.35781150
14presynaptic membrane assembly (GO:0097105)4.35272262
15layer formation in cerebral cortex (GO:0021819)4.21021637
16cranial nerve morphogenesis (GO:0021602)4.20106198
17dendritic spine morphogenesis (GO:0060997)4.19022785
18negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.16398201
19cerebellar Purkinje cell differentiation (GO:0021702)4.15776551
20neuron cell-cell adhesion (GO:0007158)4.13208547
21spinal cord association neuron differentiation (GO:0021527)4.12188731
22negative regulation of axon guidance (GO:1902668)4.10725497
23positive regulation of catecholamine secretion (GO:0033605)4.01263479
24cell migration in hindbrain (GO:0021535)3.99480453
25positive regulation of gastrulation (GO:2000543)3.97040433
26mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.94979098
27regulation of synapse assembly (GO:0051963)3.92692850
28sequestering of actin monomers (GO:0042989)3.91730916
29positive regulation of synapse assembly (GO:0051965)3.90247775
30respiratory system process (GO:0003016)3.84176154
31behavioral response to nicotine (GO:0035095)3.83699616
32establishment of nucleus localization (GO:0040023)3.80409015
33gamma-aminobutyric acid transport (GO:0015812)3.80234207
34thalamus development (GO:0021794)3.79069464
35semaphorin-plexin signaling pathway (GO:0071526)3.78817705
36adult feeding behavior (GO:0008343)3.77472187
37hippocampus development (GO:0021766)3.74736970
38neuronal ion channel clustering (GO:0045161)3.73981622
39synapse assembly (GO:0007416)3.71086943
40glycosphingolipid biosynthetic process (GO:0006688)3.61790487
41cell junction maintenance (GO:0034331)3.60925573
42dosage compensation (GO:0007549)3.56816864
43cell-cell junction maintenance (GO:0045217)3.56222618
44negative chemotaxis (GO:0050919)3.55891366
45protein localization to cilium (GO:0061512)3.51982777
46nonmotile primary cilium assembly (GO:0035058)3.46777766
47forebrain neuron development (GO:0021884)3.44675503
48retinal ganglion cell axon guidance (GO:0031290)3.44590462
49axon ensheathment in central nervous system (GO:0032291)3.44068972
50central nervous system myelination (GO:0022010)3.44068972
51dendrite morphogenesis (GO:0048813)3.43029866
52calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.42708497
53central nervous system projection neuron axonogenesis (GO:0021952)3.42106781
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.41476283
55mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.36065198
56positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.36065198
57regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.35062939
58facial nerve structural organization (GO:0021612)3.32351118
59cerebral cortex radially oriented cell migration (GO:0021799)3.31851222
60positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.31678329
61regulation of action potential (GO:0098900)3.29279874
62chaperone-mediated protein transport (GO:0072321)3.28810297
63gastrulation with mouth forming second (GO:0001702)3.27928212
64startle response (GO:0001964)3.26458726
65synaptic vesicle maturation (GO:0016188)3.26192070
66regulation of synapse organization (GO:0050807)3.24889759
67negative regulation of axon extension (GO:0030517)3.23439246
68transmission of nerve impulse (GO:0019226)3.22789247
69N-glycan processing (GO:0006491)3.21308144
70somite development (GO:0061053)3.20806570
71growth hormone secretion (GO:0030252)3.20303538
72spinal cord development (GO:0021510)3.17876122
73regulation of feeding behavior (GO:0060259)3.17369489
74atrial cardiac muscle cell action potential (GO:0086014)3.13814549
75olfactory bulb development (GO:0021772)3.09938456
76positive regulation of dendritic spine development (GO:0060999)3.09900005
77regulation of chemokine-mediated signaling pathway (GO:0070099)3.06218863
78neuron migration (GO:0001764)3.05929793
79axon extension (GO:0048675)3.05633617
80ionotropic glutamate receptor signaling pathway (GO:0035235)3.04612930
81neurofilament cytoskeleton organization (GO:0060052)3.04031023
82oxidative demethylation (GO:0070989)3.04000494
83positive regulation of action potential (GO:0045760)3.03323462
84protein localization to synapse (GO:0035418)3.03288817
85regulation of axon extension involved in axon guidance (GO:0048841)3.03215999
86central nervous system neuron development (GO:0021954)3.01969877
87presynaptic membrane organization (GO:0097090)3.01865603
88regulation of short-term neuronal synaptic plasticity (GO:0048172)3.01655043
89mitochondrion transport along microtubule (GO:0047497)3.00710607
90establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.00710607
91regulation of neuron migration (GO:2001222)2.98970275
92cholesterol biosynthetic process (GO:0006695)2.98581739
93negative regulation of synaptic transmission, GABAergic (GO:0032229)2.98223904
94regulation of appetite (GO:0032098)2.97539314
95synaptic transmission, glutamatergic (GO:0035249)2.97435672
96vocalization behavior (GO:0071625)2.95924300
97substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.95841113
98substrate-independent telencephalic tangential migration (GO:0021826)2.95841113
99negative regulation of oligodendrocyte differentiation (GO:0048715)2.95645184
100sensory perception of pain (GO:0019233)2.95223405
101regulation of axon guidance (GO:1902667)2.93927118
102regulation of mitochondrial fission (GO:0090140)2.93420075
103cerebellar Purkinje cell layer development (GO:0021680)2.92434404
104cerebral cortex neuron differentiation (GO:0021895)2.92266182
105limb bud formation (GO:0060174)2.89193323
106neuronal action potential propagation (GO:0019227)2.88915955
107positive regulation of synaptic transmission, GABAergic (GO:0032230)2.87809826
108stress granule assembly (GO:0034063)2.87460473
109G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.86620728
110protein polyglutamylation (GO:0018095)2.86606397
111intraciliary transport (GO:0042073)2.86523378
112mechanosensory behavior (GO:0007638)2.86135997
113synaptic vesicle exocytosis (GO:0016079)2.84660083
114regulation of neuronal synaptic plasticity (GO:0048168)2.83047298
115regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.82986899
116cochlea development (GO:0090102)2.82910353
117membrane hyperpolarization (GO:0060081)2.80838770
118homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.80222214
119cell differentiation in hindbrain (GO:0021533)2.79551040
120epithelial cilium movement (GO:0003351)2.78842447
121regulation of development, heterochronic (GO:0040034)2.78694782
122establishment of tissue polarity (GO:0007164)2.78471075
123establishment of planar polarity (GO:0001736)2.78471075
124regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.77868890
125positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.77213648
126cranial nerve structural organization (GO:0021604)2.76867037
127regulation of synapse structural plasticity (GO:0051823)2.74931208
128histamine secretion (GO:0001821)2.74891395
129response to dietary excess (GO:0002021)2.73499178
130head development (GO:0060322)2.73341638
131neural tube formation (GO:0001841)2.73073206
132synapse organization (GO:0050808)2.72311342
133response to auditory stimulus (GO:0010996)2.71830319
134opioid receptor signaling pathway (GO:0038003)2.71435016
135sterol biosynthetic process (GO:0016126)2.69742325
136glutamate receptor signaling pathway (GO:0007215)2.69419277
137regulation of respiratory system process (GO:0044065)2.68794630
138cerebellum development (GO:0021549)2.68731341
139behavioral defense response (GO:0002209)2.67709023
140behavioral fear response (GO:0001662)2.67709023
141neuron-neuron synaptic transmission (GO:0007270)2.66530858
142neurotransmitter-gated ion channel clustering (GO:0072578)2.64709459
143RNA localization (GO:0006403)2.64391754
144membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.63937352
145regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.63849877
146cilium morphogenesis (GO:0060271)2.63265311
147synaptic transmission, cholinergic (GO:0007271)2.62902453
148regulation of glutamate receptor signaling pathway (GO:1900449)2.61388971
149positive regulation of amine transport (GO:0051954)2.61221018
150midbrain development (GO:0030901)2.60565108
151adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.60217192
152cell communication by electrical coupling (GO:0010644)2.59799661
153auditory behavior (GO:0031223)2.59141124
154sympathetic nervous system development (GO:0048485)2.59110098
155innervation (GO:0060384)2.56812917
156positive regulation of dendritic spine morphogenesis (GO:0061003)2.55922839
157neuromuscular synaptic transmission (GO:0007274)2.55432715
158regulation of synaptic vesicle exocytosis (GO:2000300)2.54393891
159cerebral cortex cell migration (GO:0021795)2.53316342
160cytoskeleton-dependent intracellular transport (GO:0030705)2.49571693
161dendritic spine organization (GO:0097061)2.49151959
162synaptic vesicle endocytosis (GO:0048488)2.46044458
163regulation of synaptic transmission, glutamatergic (GO:0051966)2.43472010
164dendrite development (GO:0016358)2.43188421
165protein-cofactor linkage (GO:0018065)2.42881779
166glutamate secretion (GO:0014047)2.42093340
167response to pheromone (GO:0019236)18.1736812

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.66844881
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.30199399
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.20654857
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.67317025
5EZH2_27304074_Chip-Seq_ESCs_Mouse3.50132352
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95373102
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.85334868
8* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.81008783
9EZH2_27294783_Chip-Seq_ESCs_Mouse2.79169381
10* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.75757688
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.73947447
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70123001
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70123001
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.64651647
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62890486
16REST_21632747_ChIP-Seq_MESCs_Mouse2.54494548
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51603608
18* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50454717
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.48841821
20GBX2_23144817_ChIP-Seq_PC3_Human2.47755041
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.42481601
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40261535
23RBPJ_22232070_ChIP-Seq_NCS_Mouse2.35235623
24PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.35087425
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.32849267
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.26998617
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26465049
28MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23239830
29ZFP281_18757296_ChIP-ChIP_E14_Mouse2.21240558
30* RNF2_27304074_Chip-Seq_NSC_Mouse2.18194591
31REST_18959480_ChIP-ChIP_MESCs_Mouse2.17569003
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.15977918
33TAF15_26573619_Chip-Seq_HEK293_Human2.15334172
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13894667
35POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10615783
36OLIG2_26023283_ChIP-Seq_AINV15_Mouse2.05033251
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98665760
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.96905266
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.88574792
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.86342243
41VDR_22108803_ChIP-Seq_LS180_Human1.85183383
42FUS_26573619_Chip-Seq_HEK293_Human1.83954803
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.76961143
44RING1B_27294783_Chip-Seq_NPCs_Mouse1.76152980
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74952937
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.68484828
47DROSHA_22980978_ChIP-Seq_HELA_Human1.67387700
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.65554755
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.64189404
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58620899
51EWS_26573619_Chip-Seq_HEK293_Human1.55796597
52IGF1R_20145208_ChIP-Seq_DFB_Human1.53938159
53CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50006916
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.49975684
55TP53_20018659_ChIP-ChIP_R1E_Mouse1.49957782
56RARB_27405468_Chip-Seq_BRAIN_Mouse1.46351284
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44556637
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.41321706
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37234370
60IRF1_19129219_ChIP-ChIP_H3396_Human1.37139517
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35985446
62SMAD4_21799915_ChIP-Seq_A2780_Human1.33823089
63FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.33045231
64RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32593483
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32123321
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31283369
67RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29014855
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28485497
69KDM2B_26808549_Chip-Seq_K562_Human1.27452882
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23058025
71HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22555768
72AR_25329375_ChIP-Seq_VCAP_Human1.22006377
73ZNF274_21170338_ChIP-Seq_K562_Hela1.21140665
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20797008
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20797008
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20681566
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19506880
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.18203873
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18061676
80* CTCF_27219007_Chip-Seq_Bcells_Human1.17692102
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17667307
82CBP_20019798_ChIP-Seq_JUKART_Human1.17667307
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17036617
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14480130
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14266922
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13985667
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13531297
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11197162
89TP53_22573176_ChIP-Seq_HFKS_Human1.09664050
90GABP_17652178_ChIP-ChIP_JURKAT_Human1.09526505
91P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09301919
92CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.08311992
93RUNX2_22187159_ChIP-Seq_PCA_Human1.08125954
94CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07755514
95EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06637869
96ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05814982
97ZNF263_19887448_ChIP-Seq_K562_Human1.05407352
98GATA1_26923725_Chip-Seq_HPCs_Mouse1.04989382
99CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04500796
100* STAT3_23295773_ChIP-Seq_U87_Human1.04160015
101ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03642815
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03176062
103TET1_21490601_ChIP-Seq_MESCs_Mouse1.02649397
104POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.02153014
105MYC_18940864_ChIP-ChIP_HL60_Human1.02087258
106TAL1_26923725_Chip-Seq_HPCs_Mouse1.01628309
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97687995
108ER_23166858_ChIP-Seq_MCF-7_Human0.96289835
109KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.96100002
110LXR_22292898_ChIP-Seq_THP-1_Human0.94418307
111TCF4_23295773_ChIP-Seq_U87_Human0.94108334
112NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93949523
113JUN_21703547_ChIP-Seq_K562_Human0.93586242
114STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93553824
115NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93008592
116P300_19829295_ChIP-Seq_ESCs_Human0.92672990
117SOX2_16153702_ChIP-ChIP_HESCs_Human0.91034282
118NANOG_18555785_Chip-Seq_ESCs_Mouse0.90485328
119SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90231629
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90169675
121KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90153657
122ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89861847
123SMAD3_21741376_ChIP-Seq_ESCs_Human0.89106313
124POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.89084666
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88088107
126SOX2_21211035_ChIP-Seq_LN229_Gbm0.87889791
127MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.87851751
128SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86242901
129SMAD3_21741376_ChIP-Seq_EPCs_Human0.83581178
130SOX3_22085726_ChIP-Seq_NPCs_Mouse0.81566264
131ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81149666
132* AR_21572438_ChIP-Seq_LNCaP_Human0.80139403
133WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79584413
134OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78896501
135* ISL1_27105846_Chip-Seq_CPCs_Mouse0.78180304
136AR_19668381_ChIP-Seq_PC3_Human0.77454248
137KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.77006940
138CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.76849968
139YY1_22570637_ChIP-Seq_MALME-3M_Human0.76760583
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.75538036
141GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74885468
142SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.74716197
143ARNT_22903824_ChIP-Seq_MCF-7_Human0.74126827
144SRY_22984422_ChIP-ChIP_TESTIS_Rat0.73873328
145REST_19997604_ChIP-ChIP_NEURONS_Mouse0.73409371
146SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.71845210

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006276_abnormal_autonomic_nervous5.37168257
2* MP0003122_maternal_imprinting4.90517098
3MP0003880_abnormal_central_pattern3.95189264
4MP0000778_abnormal_nervous_system3.93059607
5MP0005423_abnormal_somatic_nervous3.73128508
6MP0004859_abnormal_synaptic_plasticity3.43788672
7MP0010030_abnormal_orbit_morphology3.32996273
8* MP0003121_genomic_imprinting2.51462674
9MP0000538_abnormal_urinary_bladder2.44566166
10MP0003890_abnormal_embryonic-extraembry2.43162975
11MP0005646_abnormal_pituitary_gland2.42955542
12MP0002063_abnormal_learning/memory/cond2.42287477
13MP0003635_abnormal_synaptic_transmissio2.38503641
14MP0001529_abnormal_vocalization2.33057397
15MP0002822_catalepsy2.32394440
16MP0002184_abnormal_innervation2.18231301
17MP0008961_abnormal_basal_metabolism2.16249272
18MP0003787_abnormal_imprinting2.14286389
19MP0000537_abnormal_urethra_morphology2.09302446
20MP0002638_abnormal_pupillary_reflex2.08069935
21MP0010386_abnormal_urinary_bladder2.07353325
22MP0002733_abnormal_thermal_nociception1.94601874
23* MP0008995_early_reproductive_senescence1.92994819
24MP0004133_heterotaxia1.90768888
25MP0001440_abnormal_grooming_behavior1.85619995
26MP0000631_abnormal_neuroendocrine_gland1.85522085
27* MP0001984_abnormal_olfaction1.84559171
28MP0002653_abnormal_ependyma_morphology1.79959676
29MP0006292_abnormal_olfactory_placode1.79400127
30MP0005394_taste/olfaction_phenotype1.76013229
31MP0005499_abnormal_olfactory_system1.76013229
32MP0001968_abnormal_touch/_nociception1.72180692
33* MP0002557_abnormal_social/conspecific_i1.68961809
34MP0004811_abnormal_neuron_physiology1.68889072
35MP0002102_abnormal_ear_morphology1.67009047
36MP0002064_seizures1.64528589
37MP0002572_abnormal_emotion/affect_behav1.62808999
38MP0001188_hyperpigmentation1.62278105
39MP0000955_abnormal_spinal_cord1.56880366
40MP0004270_analgesia1.55647101
41MP0001970_abnormal_pain_threshold1.51356577
42* MP0005645_abnormal_hypothalamus_physiol1.50731528
43MP0009745_abnormal_behavioral_response1.47342961
44MP0001727_abnormal_embryo_implantation1.47278237
45MP0003123_paternal_imprinting1.45068297
46MP0002234_abnormal_pharynx_morphology1.43142982
47MP0008877_abnormal_DNA_methylation1.42930842
48MP0000566_synostosis1.41962498
49MP0002282_abnormal_trachea_morphology1.41098213
50MP0002882_abnormal_neuron_morphology1.36605538
51MP0002152_abnormal_brain_morphology1.36426299
52MP0006072_abnormal_retinal_apoptosis1.35997727
53MP0008789_abnormal_olfactory_epithelium1.35479140
54MP0002736_abnormal_nociception_after1.34373145
55MP0002751_abnormal_autonomic_nervous1.33797172
56MP0003119_abnormal_digestive_system1.33195158
57MP0003938_abnormal_ear_development1.32557374
58MP0005551_abnormal_eye_electrophysiolog1.28894176
59MP0003861_abnormal_nervous_system1.25721025
60MP0002938_white_spotting1.24648698
61MP0004742_abnormal_vestibular_system1.23836672
62MP0000751_myopathy1.21759678
63MP0002272_abnormal_nervous_system1.20359689
64MP0003315_abnormal_perineum_morphology1.19852318
65MP0000462_abnormal_digestive_system1.19669362
66MP0002233_abnormal_nose_morphology1.18781552
67MP0002734_abnormal_mechanical_nocicepti1.18443086
68MP0002067_abnormal_sensory_capabilities1.16031770
69MP0001486_abnormal_startle_reflex1.15877355
70MP0003011_delayed_dark_adaptation1.15116361
71MP0000049_abnormal_middle_ear1.13723382
72MP0009046_muscle_twitch1.12027463
73MP0003959_abnormal_lean_body1.10755046
74* MP0002066_abnormal_motor_capabilities/c1.07814101
75MP0003385_abnormal_body_wall1.07090824
76MP0003937_abnormal_limbs/digits/tail_de1.06845605
77MP0002735_abnormal_chemical_nociception1.06392780
78* MP0002069_abnormal_eating/drinking_beha1.05679551
79MP0004924_abnormal_behavior1.05404505
80MP0005386_behavior/neurological_phenoty1.05404505
81MP0000534_abnormal_ureter_morphology1.05119604
82MP0003329_amyloid_beta_deposits1.05040682
83MP0003942_abnormal_urinary_system1.00203310
84MP0004885_abnormal_endolymph0.98655810
85MP0004134_abnormal_chest_morphology0.97987270
86MP0003136_yellow_coat_color0.97869630
87MP0001299_abnormal_eye_distance/0.97716915
88MP0005084_abnormal_gallbladder_morpholo0.97384746
89MP0003755_abnormal_palate_morphology0.96666824
90MP0001293_anophthalmia0.95402585
91MP0002752_abnormal_somatic_nervous0.95008656
92MP0003948_abnormal_gas_homeostasis0.94929741
93MP0004145_abnormal_muscle_electrophysio0.92165384
94MP0001986_abnormal_taste_sensitivity0.91583382
95MP0003567_abnormal_fetal_cardiomyocyte0.91139884
96MP0002249_abnormal_larynx_morphology0.90382284
97MP0001501_abnormal_sleep_pattern0.89497951
98MP0001963_abnormal_hearing_physiology0.88720245
99* MP0002081_perinatal_lethality0.87597246
100MP0005448_abnormal_energy_balance0.86799977
101MP0005195_abnormal_posterior_eye0.84912549
102MP0003172_abnormal_lysosome_physiology0.84575964
103MP0003221_abnormal_cardiomyocyte_apopto0.84409758
104MP0005391_vision/eye_phenotype0.83364242
105MP0005187_abnormal_penis_morphology0.81677936
106MP0004142_abnormal_muscle_tone0.81600601
107MP0003115_abnormal_respiratory_system0.80850957
108MP0000026_abnormal_inner_ear0.78649119
109MP0001286_abnormal_eye_development0.77090725
110MP0002909_abnormal_adrenal_gland0.77046055
111MP0000647_abnormal_sebaceous_gland0.75968039
112MP0001485_abnormal_pinna_reflex0.75739670
113MP0005253_abnormal_eye_physiology0.75507657
114MP0002837_dystrophic_cardiac_calcinosis0.74414869
115MP0002229_neurodegeneration0.73953298
116MP0000639_abnormal_adrenal_gland0.73755079
117MP0001943_abnormal_respiration0.73251476
118MP0000013_abnormal_adipose_tissue0.71920353
119MP0002876_abnormal_thyroid_physiology0.71314376
120MP0001905_abnormal_dopamine_level0.71165765
121MP0003137_abnormal_impulse_conducting0.70402810
122MP0005248_abnormal_Harderian_gland0.70034187
123MP0000569_abnormal_digit_pigmentation0.69644580
124MP0005409_darkened_coat_color0.68767971
125MP0000372_irregular_coat_pigmentation0.66932511
126MP0002177_abnormal_outer_ear0.63895724
127MP0001664_abnormal_digestion0.63602283
128MP0008569_lethality_at_weaning0.62858748
129* MP0010770_preweaning_lethality0.62547248
130* MP0002082_postnatal_lethality0.62547248
131* MP0001502_abnormal_circadian_rhythm0.60438839
132MP0004858_abnormal_nervous_system0.59204742
133MP0008770_decreased_survivor_rate0.59161943
134MP0002116_abnormal_craniofacial_bone0.58096543

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)6.12381809
2* Polyphagia (HP:0002591)5.14278654
3* Failure to thrive in infancy (HP:0001531)4.61666875
4Abnormal hair whorl (HP:0010721)4.32931954
5Focal motor seizures (HP:0011153)4.30913118
6Exotropia (HP:0000577)4.25947059
7Myokymia (HP:0002411)4.14742038
8* Abnormal eating behavior (HP:0100738)4.11781152
9Oligomenorrhea (HP:0000876)4.05634690
10Growth hormone deficiency (HP:0000824)3.97739273
11Focal seizures (HP:0007359)3.67802872
12Specific learning disability (HP:0001328)3.63597698
13Poor suck (HP:0002033)3.61862828
14Hip dysplasia (HP:0001385)3.60098221
15Hypoventilation (HP:0002791)3.56371689
16Limb dystonia (HP:0002451)3.55694657
17Supranuclear gaze palsy (HP:0000605)3.55001746
18Cortical dysplasia (HP:0002539)3.51317121
19* Esotropia (HP:0000565)3.48551489
20High anterior hairline (HP:0009890)3.41188961
21Lissencephaly (HP:0001339)3.33010782
22Drooling (HP:0002307)3.28455685
23Excessive salivation (HP:0003781)3.28455685
24Agitation (HP:0000713)3.27568731
25Thyroid-stimulating hormone excess (HP:0002925)3.25374473
26Narrow nasal bridge (HP:0000446)3.14543913
27Retinal dysplasia (HP:0007973)3.14009762
28Labial hypoplasia (HP:0000066)3.06179998
29Medial flaring of the eyebrow (HP:0010747)3.02729691
30Generalized hypotonia (HP:0001290)3.00400681
31Anterior segment dysgenesis (HP:0007700)2.98573901
32Hypoplasia of the brainstem (HP:0002365)2.98406696
33Aplasia/Hypoplasia of the brainstem (HP:0007362)2.98406696
34Ankle clonus (HP:0011448)2.97087878
35True hermaphroditism (HP:0010459)2.91955238
36Congenital primary aphakia (HP:0007707)2.91480044
37Nephrogenic diabetes insipidus (HP:0009806)2.90274062
38Hemiparesis (HP:0001269)2.77748260
39Pachygyria (HP:0001302)2.77337538
40Hypoplastic female external genitalia (HP:0012815)2.75851943
41Neoplasm of the heart (HP:0100544)2.75211469
42Pancreatic fibrosis (HP:0100732)2.69626277
43Sex reversal (HP:0012245)2.66876268
44Abnormal sex determination (HP:0012244)2.66876268
45Hyperacusis (HP:0010780)2.66710750
46Insomnia (HP:0100785)2.65054605
47* Sleep apnea (HP:0010535)2.65051603
48Pancreatic cysts (HP:0001737)2.60931166
49Wrist flexion contracture (HP:0001239)2.58529019
50Genital tract atresia (HP:0001827)2.55672604
51Vaginal atresia (HP:0000148)2.53970421
52Shawl scrotum (HP:0000049)2.53727953
53Type II lissencephaly (HP:0007260)2.53456448
54Amblyopia (HP:0000646)2.50715128
55Atonic seizures (HP:0010819)2.49092001
56Molar tooth sign on MRI (HP:0002419)2.44789458
57Abnormality of midbrain morphology (HP:0002418)2.44789458
58Coronal craniosynostosis (HP:0004440)2.44351811
59Nephronophthisis (HP:0000090)2.44104550
60Megalocornea (HP:0000485)2.34268365
61Amyotrophic lateral sclerosis (HP:0007354)2.33303542
62Split foot (HP:0001839)2.32484957
63Hypsarrhythmia (HP:0002521)2.32393652
64Protruding tongue (HP:0010808)2.31841603
65Progressive cerebellar ataxia (HP:0002073)2.28950888
66Abnormality of the corticospinal tract (HP:0002492)2.26071383
67Intestinal atresia (HP:0011100)2.22762651
68EEG with generalized epileptiform discharges (HP:0011198)2.21061660
69Nasal speech (HP:0001611)2.20597888
70Renal duplication (HP:0000075)2.19778478
71Hypoglycemic seizures (HP:0002173)2.18952531
72Elfin facies (HP:0004428)2.17877086
73Atelectasis (HP:0100750)2.17765607
74Symptomatic seizures (HP:0011145)2.17514052
75Occipital encephalocele (HP:0002085)2.17357524
76Renovascular hypertension (HP:0100817)2.17138318
77Neonatal respiratory distress (HP:0002643)2.16413134
78Abnormality of the labia (HP:0000058)2.15528440
79Epileptiform EEG discharges (HP:0011182)2.15042774
80Postaxial hand polydactyly (HP:0001162)2.14582400
81Optic nerve hypoplasia (HP:0000609)2.13880320
82Precocious puberty (HP:0000826)2.13448731
83Oligodactyly (hands) (HP:0001180)2.12693851
84Mutism (HP:0002300)2.12675078
85Torticollis (HP:0000473)2.10182347
86Impaired vibration sensation in the lower limbs (HP:0002166)2.09993165
87Chronic hepatic failure (HP:0100626)2.09714230
88Iris hypopigmentation (HP:0007730)2.08941223
89Spastic tetraplegia (HP:0002510)2.08424620
90Broad-based gait (HP:0002136)2.07668050
91Shoulder girdle muscle weakness (HP:0003547)2.07320379
92Absence seizures (HP:0002121)2.06183939
93Gait imbalance (HP:0002141)2.05492154
94Hyperventilation (HP:0002883)2.05291923
95Autism (HP:0000717)2.04019761
96Poor eye contact (HP:0000817)2.03406165
97Impaired pain sensation (HP:0007328)2.02852921
98Abnormality of pain sensation (HP:0010832)2.02852921
99Hepatoblastoma (HP:0002884)2.01963825
100Attention deficit hyperactivity disorder (HP:0007018)1.99618283
101Generalized tonic-clonic seizures (HP:0002069)1.99122400
102Depression (HP:0000716)1.98069536
103Poor coordination (HP:0002370)1.96643020
104Abnormality of the metopic suture (HP:0005556)1.96099415
105Obsessive-compulsive behavior (HP:0000722)1.95879768
106Synostosis involving the elbow (HP:0003938)1.95719691
107Humeroradial synostosis (HP:0003041)1.95719691
108Dialeptic seizures (HP:0011146)1.95433802
109Hyperthyroidism (HP:0000836)1.94932609
110Hypogonadotrophic hypogonadism (HP:0000044)1.94926687
111* Narrow forehead (HP:0000341)1.94790886
112Abnormality of the lower motor neuron (HP:0002366)1.94288042
113Epileptic encephalopathy (HP:0200134)1.94187054
114Urinary urgency (HP:0000012)1.93848672
115Broad foot (HP:0001769)1.93627222
116Craniofacial dystonia (HP:0012179)1.93356279
117Septo-optic dysplasia (HP:0100842)1.93209651
118Deep palmar crease (HP:0006191)1.93155362
119Focal dystonia (HP:0004373)1.93044018
120Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92709660
121Degeneration of the lateral corticospinal tracts (HP:0002314)1.92535486
122Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.92535486
123Abnormality of salivation (HP:0100755)1.90878839
124Spastic gait (HP:0002064)1.90572877
125Polymicrogyria (HP:0002126)1.90433044
126Aplasia/Hypoplasia of the clavicles (HP:0006710)1.90409737
127Febrile seizures (HP:0002373)1.90225064
128Hypoplasia of the corpus callosum (HP:0002079)1.90041201
129Sporadic (HP:0003745)1.89173653
130Acute necrotizing encephalopathy (HP:0006965)1.89161966
131Decreased testicular size (HP:0008734)1.86639220
132Generalized hypopigmentation (HP:0007513)1.86257262
133Broad alveolar ridges (HP:0000187)1.85276038
134Thin upper lip vermilion (HP:0000219)1.84981716
135Sclerocornea (HP:0000647)1.84194306
136Absent speech (HP:0001344)1.84109771
137Anencephaly (HP:0002323)1.83314706
138Scrotal hypoplasia (HP:0000046)1.82327629
139Postaxial foot polydactyly (HP:0001830)1.82226139
140Aplasia/Hypoplasia of the tongue (HP:0010295)1.82090469
141Visual hallucinations (HP:0002367)1.81652480
142Decreased muscle mass (HP:0003199)1.81623421
143Oligodactyly (HP:0012165)1.81524418
144Hyperglycinemia (HP:0002154)1.81509604
145Congenital stationary night blindness (HP:0007642)1.80859737
146Overriding aorta (HP:0002623)1.80766735
147Abnormality of glycosphingolipid metabolism (HP:0004343)1.80401706
148Abnormality of glycolipid metabolism (HP:0010969)1.80401706
149Abnormality of liposaccharide metabolism (HP:0010968)1.80401706
150Psychosis (HP:0000709)1.80363677
151Cerebellar dysplasia (HP:0007033)1.80287312
152* Open mouth (HP:0000194)1.79986434
153Morphological abnormality of the pyramidal tract (HP:0002062)1.79569562
154Inability to walk (HP:0002540)1.79478443
155Hypothermia (HP:0002045)1.77655588
156Abnormality of the renal medulla (HP:0100957)1.77395621
157Hypoplastic pelvis (HP:0008839)1.77332969
158Impaired social interactions (HP:0000735)1.77168786
159Abnormal social behavior (HP:0012433)1.77168786
160Abnormal EKG (HP:0003115)1.76939627
161Muscular hypotonia of the trunk (HP:0008936)1.76022432
162Abnormal pancreas size (HP:0012094)1.74818085
163Anophthalmia (HP:0000528)1.74384594
164Short foot (HP:0001773)1.73267137
165* Micropenis (HP:0000054)1.71791854

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK36.61906933
2EPHB24.38167441
3SIK33.93205366
4MAP3K93.36947140
5MARK13.26060997
6TRIM283.20298079
7MAP4K23.19527592
8MAP3K123.19251946
9IRAK23.15847397
10KSR12.91933811
11BCR2.87400345
12UHMK12.65038458
13NTRK22.23164660
14PAK62.19525290
15MAP2K42.08212063
16PINK12.02071227
17DYRK21.87765208
18MINK11.86556021
19ERBB21.72264030
20ICK1.62290409
21ACVR1B1.60187793
22PAK31.54037661
23IRAK41.51071967
24MAP3K41.50964574
25EPHA31.47736132
26BCKDK1.45742578
27PRKD31.39165964
28DYRK1B1.34366500
29NTRK31.34361358
30MAPK131.29159408
31BRD41.25324471
32TYRO31.24806134
33PHKG21.21418821
34PHKG11.21418821
35DAPK21.20409088
36IRAK11.19276067
37SRPK11.18240719
38EPHA41.16524440
39MARK21.15033330
40MAP2K71.12489484
41CDK181.12441984
42FER1.12076341
43MAP2K61.06556786
44BMPR1B1.05419530
45FGFR21.05200101
46CDK51.01709191
47ADRBK20.95226469
48RPS6KA40.94340241
49CAMK1D0.92035176
50CDK150.89815006
51CAMK1G0.89194770
52PLK20.89020286
53PRKCE0.88503185
54CDK140.87693750
55CDK190.86843868
56MAP3K110.83018925
57CSNK1G30.80612484
58INSRR0.79242729
59GRK10.79061706
60CDK11A0.76216441
61TNIK0.75544905
62ERN10.73907735
63LMTK20.72645253
64NEK10.72178932
65CCNB10.69003741
66TESK20.67152476
67WNK40.66511389
68FRK0.64652543
69MAPK90.64086411
70ERBB30.61947317
71AKT20.59962747
72SGK4940.59862566
73SGK2230.59862566
74TGFBR10.59722858
75MAPK150.58867601
76MAP3K100.58654062
77TESK10.57289291
78CSNK1G20.56832821
79SIK20.56773434
80RPS6KA20.56666924
81CSNK1A1L0.56606640
82VRK10.55254303
83PRKCZ0.54955979
84MKNK10.53534922
85ROCK10.53456247
86PNCK0.52470006
87MKNK20.52365961
88DYRK1A0.50906230
89AKT30.50782470
90CAMK40.50775674
91CSNK1G10.49893238
92PRKACA0.47904901
93MAP2K20.46564078
94ADRBK10.44914455
95TSSK60.44746945
96CSNK1A10.43673595
97FES0.43591489
98RIPK10.42625582
99SGK20.42259030
100MAP3K60.41465479
101LATS20.41056119
102ROCK20.39939034
103NTRK10.39565225
104PRKACB0.38883094
105PAK20.38336462
106FLT30.38165294
107LIMK10.37007342
108DDR20.35933605
109PDGFRA0.35821147
110CAMK2D0.35464677
111DYRK30.35426369
112TLK10.35261029
113FYN0.34195970
114PKN20.34152148
115STK38L0.34129002
116CSNK1D0.32973210
117PRKG10.32414069
118CAMK10.31919661
119PRKACG0.31655700
120MAPK40.30953596
121FGFR10.30902061
122RPS6KA50.30875538
123CAMKK20.29641466
124NUAK10.29550105
125FGFR40.29514973
126PLK30.28032404
127PKN10.27410244
128KSR20.27295086
129SGK10.26779798
130CAMK2A0.25403187
131OXSR10.24312608
132GRK70.23937511
133MAP3K50.23256481
134MAPK100.22944239
135PRKAA10.22868247
136PRKCG0.21367568
137MAP2K10.20383033
138ATR0.19973076
139CSNK1E0.18947891
140GSK3B0.18267864
141CASK0.18018709
142CAMK2B0.17030779

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.25734438
2Axon guidance_Homo sapiens_hsa043604.18644797
3Steroid biosynthesis_Homo sapiens_hsa001002.96269450
4Synaptic vesicle cycle_Homo sapiens_hsa047212.93687562
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.43010587
6Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.42762852
7Protein export_Homo sapiens_hsa030602.20847893
8GABAergic synapse_Homo sapiens_hsa047272.17078199
9Gap junction_Homo sapiens_hsa045402.01585423
10Cocaine addiction_Homo sapiens_hsa050301.94024345
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.92728276
12Collecting duct acid secretion_Homo sapiens_hsa049661.89167291
13Dopaminergic synapse_Homo sapiens_hsa047281.84470838
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.81563862
15Cardiac muscle contraction_Homo sapiens_hsa042601.75934009
16Insulin secretion_Homo sapiens_hsa049111.71979438
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66888136
18Morphine addiction_Homo sapiens_hsa050321.63275555
19Glutamatergic synapse_Homo sapiens_hsa047241.61015585
20Vibrio cholerae infection_Homo sapiens_hsa051101.57679403
21Circadian entrainment_Homo sapiens_hsa047131.56465824
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.54862824
23Basal cell carcinoma_Homo sapiens_hsa052171.53466379
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47488452
25Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.47090687
26Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.46679550
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36390185
28Olfactory transduction_Homo sapiens_hsa047401.33308124
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.30919960
30Melanogenesis_Homo sapiens_hsa049161.28696052
31Serotonergic synapse_Homo sapiens_hsa047261.27532490
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25482684
33Cholinergic synapse_Homo sapiens_hsa047251.25157227
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22756970
35Amphetamine addiction_Homo sapiens_hsa050311.19680875
36Phagosome_Homo sapiens_hsa041451.19564626
37Colorectal cancer_Homo sapiens_hsa052101.19546340
38Wnt signaling pathway_Homo sapiens_hsa043101.17997092
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.17605138
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13713780
41Oxidative phosphorylation_Homo sapiens_hsa001901.13349029
42GnRH signaling pathway_Homo sapiens_hsa049121.10389141
43Basal transcription factors_Homo sapiens_hsa030221.07082524
44Butanoate metabolism_Homo sapiens_hsa006501.06067566
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05936686
46Oxytocin signaling pathway_Homo sapiens_hsa049211.04485136
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03984967
48Taste transduction_Homo sapiens_hsa047421.03658163
49Notch signaling pathway_Homo sapiens_hsa043301.02428657
50Ether lipid metabolism_Homo sapiens_hsa005651.00747562
51Hippo signaling pathway_Homo sapiens_hsa043901.00613958
52Parkinsons disease_Homo sapiens_hsa050121.00314211
53ErbB signaling pathway_Homo sapiens_hsa040121.00206190
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99680768
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99486895
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98329448
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98282401
58Propanoate metabolism_Homo sapiens_hsa006400.97960666
59Oocyte meiosis_Homo sapiens_hsa041140.96809190
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93725198
61VEGF signaling pathway_Homo sapiens_hsa043700.93085210
62Renin secretion_Homo sapiens_hsa049240.91674430
63Dilated cardiomyopathy_Homo sapiens_hsa054140.91418200
64Long-term potentiation_Homo sapiens_hsa047200.91237672
65MAPK signaling pathway_Homo sapiens_hsa040100.89093727
66Endometrial cancer_Homo sapiens_hsa052130.88879287
67Prion diseases_Homo sapiens_hsa050200.88492829
68Peroxisome_Homo sapiens_hsa041460.87775909
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87752604
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86707672
71Long-term depression_Homo sapiens_hsa047300.83520520
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83329684
73Renal cell carcinoma_Homo sapiens_hsa052110.83120479
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82760775
75Salivary secretion_Homo sapiens_hsa049700.80274553
76Huntingtons disease_Homo sapiens_hsa050160.79896860
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79453919
78Alcoholism_Homo sapiens_hsa050340.78263990
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.78192635
80Linoleic acid metabolism_Homo sapiens_hsa005910.77190170
81Circadian rhythm_Homo sapiens_hsa047100.76084054
82Hedgehog signaling pathway_Homo sapiens_hsa043400.75199122
83Gastric acid secretion_Homo sapiens_hsa049710.74634489
84Fatty acid elongation_Homo sapiens_hsa000620.73567552
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68943872
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67370405
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66358276
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64677218
89Selenocompound metabolism_Homo sapiens_hsa004500.64418169
90Choline metabolism in cancer_Homo sapiens_hsa052310.64090897
91mRNA surveillance pathway_Homo sapiens_hsa030150.63544396
92Calcium signaling pathway_Homo sapiens_hsa040200.63224852
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62693518
94Estrogen signaling pathway_Homo sapiens_hsa049150.62654848
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61750433
96N-Glycan biosynthesis_Homo sapiens_hsa005100.60768141
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60004218
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.59038860
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.56756606
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56462080
101Endocytosis_Homo sapiens_hsa041440.56358870
102Folate biosynthesis_Homo sapiens_hsa007900.55472482
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.55347028
104Caffeine metabolism_Homo sapiens_hsa002320.53480908
105Alzheimers disease_Homo sapiens_hsa050100.53020658
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.52903012
107Fanconi anemia pathway_Homo sapiens_hsa034600.52611034
108Regulation of autophagy_Homo sapiens_hsa041400.52382317
109Fatty acid metabolism_Homo sapiens_hsa012120.52077035
110Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50454540
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50082407
112Sulfur relay system_Homo sapiens_hsa041220.49730203
113Ovarian steroidogenesis_Homo sapiens_hsa049130.49506161
114Type II diabetes mellitus_Homo sapiens_hsa049300.48557435
115AMPK signaling pathway_Homo sapiens_hsa041520.48154294
116RNA polymerase_Homo sapiens_hsa030200.47444457
117RNA degradation_Homo sapiens_hsa030180.47392255
118Metabolic pathways_Homo sapiens_hsa011000.47280985
119Fat digestion and absorption_Homo sapiens_hsa049750.46958959
120cAMP signaling pathway_Homo sapiens_hsa040240.46802317
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45519045
122Tryptophan metabolism_Homo sapiens_hsa003800.44814738
123Salmonella infection_Homo sapiens_hsa051320.40857110
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.37197847
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36097108
126Renin-angiotensin system_Homo sapiens_hsa046140.36037428
127Viral myocarditis_Homo sapiens_hsa054160.35267876
128Ras signaling pathway_Homo sapiens_hsa040140.35248318
129Dorso-ventral axis formation_Homo sapiens_hsa043200.34312957
130Insulin signaling pathway_Homo sapiens_hsa049100.34041585
131Fatty acid biosynthesis_Homo sapiens_hsa000610.33833471
132beta-Alanine metabolism_Homo sapiens_hsa004100.32918462
133Rap1 signaling pathway_Homo sapiens_hsa040150.32076350
134Phototransduction_Homo sapiens_hsa047440.31747740
135Tight junction_Homo sapiens_hsa045300.31530459
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31050841
137Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29317508
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26802367
139Shigellosis_Homo sapiens_hsa051310.25457259

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