MAGI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.76116713
2synaptic vesicle maturation (GO:0016188)4.76006600
3vocalization behavior (GO:0071625)4.49532354
4neuron cell-cell adhesion (GO:0007158)4.45584677
5glutamate secretion (GO:0014047)4.35872720
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.22698695
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.11077300
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.10460973
9layer formation in cerebral cortex (GO:0021819)4.08821930
10synaptic vesicle exocytosis (GO:0016079)4.08234131
11protein localization to synapse (GO:0035418)4.04117806
12gamma-aminobutyric acid transport (GO:0015812)3.92211503
13regulation of synaptic vesicle exocytosis (GO:2000300)3.85672046
14regulation of glutamate receptor signaling pathway (GO:1900449)3.74445407
15neuronal action potential propagation (GO:0019227)3.73103418
16locomotory exploration behavior (GO:0035641)3.71406390
17cell migration in hindbrain (GO:0021535)3.70697232
18ionotropic glutamate receptor signaling pathway (GO:0035235)3.68247389
19regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.67955264
20proline transport (GO:0015824)3.66761644
21neurotransmitter secretion (GO:0007269)3.63742751
22neurotransmitter-gated ion channel clustering (GO:0072578)3.62195920
23presynaptic membrane assembly (GO:0097105)3.60796320
24neuron recognition (GO:0008038)3.57535377
25synaptic transmission, glutamatergic (GO:0035249)3.56733597
26presynaptic membrane organization (GO:0097090)3.51072543
27paraxial mesoderm development (GO:0048339)3.48959805
28glutamate receptor signaling pathway (GO:0007215)3.48496001
29axonal fasciculation (GO:0007413)3.41958911
30dendritic spine morphogenesis (GO:0060997)3.39379928
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.36919880
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.35257965
33neuron-neuron synaptic transmission (GO:0007270)3.31027265
34regulation of synaptic vesicle transport (GO:1902803)3.27867536
35G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.17590334
36regulation of neuronal synaptic plasticity (GO:0048168)3.14852835
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.14604058
38transmission of nerve impulse (GO:0019226)3.13831623
39cellular potassium ion homeostasis (GO:0030007)3.12668666
40dendrite morphogenesis (GO:0048813)3.12178308
41neurotransmitter transport (GO:0006836)3.11435249
42cerebellar Purkinje cell differentiation (GO:0021702)3.08461200
43positive regulation of synaptic transmission, GABAergic (GO:0032230)3.03328269
44gamma-aminobutyric acid signaling pathway (GO:0007214)3.00982271
45exploration behavior (GO:0035640)3.00277488
46nucleobase catabolic process (GO:0046113)2.99946358
47negative regulation of synaptic transmission, GABAergic (GO:0032229)2.98709273
48postsynaptic membrane organization (GO:0001941)2.98295831
49cerebellar granule cell differentiation (GO:0021707)2.94264074
50innervation (GO:0060384)2.94059772
51positive regulation of synapse maturation (GO:0090129)2.93967650
52membrane hyperpolarization (GO:0060081)2.92309118
53regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.90569666
54regulation of long-term neuronal synaptic plasticity (GO:0048169)2.90256168
55limb bud formation (GO:0060174)2.86625791
56negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.85480778
57synapse assembly (GO:0007416)2.85315238
58auditory behavior (GO:0031223)2.84694032
59regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.83564711
60regulation of synaptic transmission, glutamatergic (GO:0051966)2.82232756
61membrane depolarization during action potential (GO:0086010)2.79490593
62synaptic vesicle endocytosis (GO:0048488)2.79203813
63positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.78279337
64regulation of neurotransmitter levels (GO:0001505)2.77816323
65regulation of synapse structural plasticity (GO:0051823)2.77117673
66regulation of postsynaptic membrane potential (GO:0060078)2.76948363
67regulation of excitatory postsynaptic membrane potential (GO:0060079)2.76710608
68regulation of dendritic spine morphogenesis (GO:0061001)2.76429775
69central nervous system projection neuron axonogenesis (GO:0021952)2.76325086
70positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.73641067
71long-term memory (GO:0007616)2.72470065
72central nervous system myelination (GO:0022010)2.71228567
73axon ensheathment in central nervous system (GO:0032291)2.71228567
74apical protein localization (GO:0045176)2.71064342
75response to auditory stimulus (GO:0010996)2.70636922
76synapse organization (GO:0050808)2.68755208
77mating behavior (GO:0007617)2.68543781
78neuronal ion channel clustering (GO:0045161)2.68318341
79positive regulation of synapse assembly (GO:0051965)2.68062334
80adult walking behavior (GO:0007628)2.67901024
81regulation of posttranscriptional gene silencing (GO:0060147)2.67279299
82regulation of gene silencing by miRNA (GO:0060964)2.67279299
83regulation of gene silencing by RNA (GO:0060966)2.67279299
84cell communication by electrical coupling (GO:0010644)2.66989347
85cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.65728187
86glycine transport (GO:0015816)2.65205494
87detection of temperature stimulus (GO:0016048)2.64203260
88regulation of neurotransmitter secretion (GO:0046928)2.63811965
89positive regulation of dendritic spine morphogenesis (GO:0061003)2.63588268
90negative regulation of translation, ncRNA-mediated (GO:0040033)2.60915445
91regulation of translation, ncRNA-mediated (GO:0045974)2.60915445
92negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.60915445
93embryonic retina morphogenesis in camera-type eye (GO:0060059)2.60725291
94calcium-mediated signaling using intracellular calcium source (GO:0035584)2.60460149
95positive regulation of membrane potential (GO:0045838)2.59813182
96positive regulation of potassium ion transmembrane transport (GO:1901381)2.59454833
97cerebral cortex radially oriented cell migration (GO:0021799)2.57115274
98startle response (GO:0001964)2.55534907
99membrane depolarization (GO:0051899)2.55461523
100establishment of mitochondrion localization (GO:0051654)2.55411855
101establishment of nucleus localization (GO:0040023)2.54219949
102pyrimidine nucleobase catabolic process (GO:0006208)2.53889955
103neuromuscular process controlling balance (GO:0050885)2.53147776
104regulation of synapse maturation (GO:0090128)2.52930751
105behavioral defense response (GO:0002209)2.51838488
106behavioral fear response (GO:0001662)2.51838488
107sodium ion export (GO:0071436)2.49810668
108regulation of synaptic plasticity (GO:0048167)2.48621931
109regulation of synaptic transmission, GABAergic (GO:0032228)2.48339467
110membrane repolarization (GO:0086009)2.48091138
111synaptic transmission (GO:0007268)2.47688853
112potassium ion homeostasis (GO:0055075)2.46151089
113regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.32515770
114notochord development (GO:0030903)2.30050105
115calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.29417260
116spinal cord development (GO:0021510)2.28466780
117neuronal stem cell maintenance (GO:0097150)2.27235485
118retinal ganglion cell axon guidance (GO:0031290)2.23747670
119lateral sprouting from an epithelium (GO:0060601)2.22771193
120ephrin receptor signaling pathway (GO:0048013)2.18217250
121limb development (GO:0060173)2.17813404
122appendage development (GO:0048736)2.17813404
123mechanosensory behavior (GO:0007638)2.17170277
124regulation of non-canonical Wnt signaling pathway (GO:2000050)2.17017405
125artery development (GO:0060840)2.15450597
126kidney morphogenesis (GO:0060993)2.14932766
127axon extension (GO:0048675)2.13908481
128axon extension involved in axon guidance (GO:0048846)2.13466002
129neuron projection extension involved in neuron projection guidance (GO:1902284)2.13466002
130negative regulation of cytosolic calcium ion concentration (GO:0051481)2.12289980
131otic vesicle formation (GO:0030916)2.10961511
132inner ear receptor cell development (GO:0060119)2.10698102
133positive regulation of action potential (GO:0045760)2.09503770
134cochlea development (GO:0090102)2.08928614
135cerebral cortex cell migration (GO:0021795)2.04413566
136lung-associated mesenchyme development (GO:0060484)2.04128799
137convergent extension (GO:0060026)2.03679610
138pre-miRNA processing (GO:0031054)2.03440418
139dorsal/ventral axis specification (GO:0009950)2.03404641
140negative regulation of oligodendrocyte differentiation (GO:0048715)2.03122063
141negative regulation of fibroblast apoptotic process (GO:2000270)2.02516488
142ganglion development (GO:0061548)2.02220743
143olfactory bulb development (GO:0021772)2.00369140
144negative regulation of astrocyte differentiation (GO:0048712)2.00167767
145forebrain neuron differentiation (GO:0021879)1.99815418
146gastrulation with mouth forming second (GO:0001702)1.99262536
147regulation of axon guidance (GO:1902667)1.99236384
148regulation of synapse assembly (GO:0051963)1.99149299
149C4-dicarboxylate transport (GO:0015740)1.99119337
150cranial nerve development (GO:0021545)1.96665522
151dendrite development (GO:0016358)1.96139404
152negative regulation of glial cell differentiation (GO:0045686)1.95930867
153camera-type eye morphogenesis (GO:0048593)1.94939395
154prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060521.94551977
155embryonic foregut morphogenesis (GO:0048617)1.94274860
156regulation of axon extension involved in axon guidance (GO:0048841)1.94166434
157nonmotile primary cilium assembly (GO:0035058)1.93808754

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.96240196
2GBX2_23144817_ChIP-Seq_PC3_Human3.38090726
3RBPJ_22232070_ChIP-Seq_NCS_Mouse2.84092546
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.81189167
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.75928501
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73316756
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64219116
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64219116
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.52131532
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48821012
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.45481708
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.45352319
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33386379
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.31539707
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.29404831
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29338223
17REST_21632747_ChIP-Seq_MESCs_Mouse2.18261002
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17796784
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14961785
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10731445
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.10590778
22DROSHA_22980978_ChIP-Seq_HELA_Human2.08002297
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.07047006
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97951107
25RARB_27405468_Chip-Seq_BRAIN_Mouse1.75494689
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75246214
27FUS_26573619_Chip-Seq_HEK293_Human1.75239361
28* REST_18959480_ChIP-ChIP_MESCs_Mouse1.70550700
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65860638
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63436226
31TAF15_26573619_Chip-Seq_HEK293_Human1.59807050
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59369080
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.57714350
34AR_21572438_ChIP-Seq_LNCaP_Human1.56721962
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55896706
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.55675808
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55208468
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55072813
39* SMAD4_21799915_ChIP-Seq_A2780_Human1.50207053
40* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49243612
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44289831
42RNF2_27304074_Chip-Seq_NSC_Mouse1.43964831
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42378195
44* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40975901
45* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38346800
46* PIAS1_25552417_ChIP-Seq_VCAP_Human1.37067536
47RING1B_27294783_Chip-Seq_NPCs_Mouse1.34549440
48EWS_26573619_Chip-Seq_HEK293_Human1.34266886
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.33714313
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33526907
51AHR_22903824_ChIP-Seq_MCF-7_Human1.31118651
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29487875
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28818223
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26713181
55* STAT3_23295773_ChIP-Seq_U87_Human1.25706474
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.25343225
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25293878
58* P300_19829295_ChIP-Seq_ESCs_Human1.23401741
59* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22841847
60KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.22767153
61* SOX2_21211035_ChIP-Seq_LN229_Gbm1.22714293
62* SMAD3_21741376_ChIP-Seq_EPCs_Human1.22583097
63* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22115334
64SOX9_26525672_Chip-Seq_HEART_Mouse1.21911362
65* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.20777887
66* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.20486633
67* EP300_21415370_ChIP-Seq_HL-1_Mouse1.19336693
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18759872
69* AR_19668381_ChIP-Seq_PC3_Human1.18208759
70* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15723635
71RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15275260
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15029525
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13007503
74* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12350696
75VDR_22108803_ChIP-Seq_LS180_Human1.10525473
76* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10053122
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09331548
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09331548
79* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08404357
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07334893
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07144653
82STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06505350
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05711610
84AR_25329375_ChIP-Seq_VCAP_Human1.05077082
85SMAD3_21741376_ChIP-Seq_ESCs_Human1.04792867
86WT1_19549856_ChIP-ChIP_CCG9911_Human1.04488087
87* SMAD4_21741376_ChIP-Seq_HESCs_Human1.04261221
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03803241
89IGF1R_20145208_ChIP-Seq_DFB_Human1.02997959
90* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02902972
91NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02713742
92SOX2_16153702_ChIP-ChIP_HESCs_Human1.02657816
93P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02366257
94* SMAD3_21741376_ChIP-Seq_HESCs_Human1.00911243
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00859916
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00742352
97* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00350503
98GATA1_26923725_Chip-Seq_HPCs_Mouse1.00072721
99MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99776324
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99746180
101* TCF4_23295773_ChIP-Seq_U87_Human0.98499383
102* RUNX2_22187159_ChIP-Seq_PCA_Human0.98125332
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97739740
104TP53_20018659_ChIP-ChIP_R1E_Mouse0.96560200
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96410384
106* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94525640
107ZNF274_21170338_ChIP-Seq_K562_Hela0.94397417
108NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94360776
109KDM2B_26808549_Chip-Seq_K562_Human0.92957716
110* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92170860
111* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91284576
112* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91133085
113TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89994749
114POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89674277
115* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88490105
116SMAD_19615063_ChIP-ChIP_OVARY_Human0.88012404
117TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87904462
118RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87772387
119ISL1_27105846_Chip-Seq_CPCs_Mouse0.86058040
120* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84694362
121POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84514255

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.34988118
2MP0003880_abnormal_central_pattern4.06181277
3MP0004270_analgesia3.27215998
4MP0003635_abnormal_synaptic_transmissio3.10029680
5MP0001968_abnormal_touch/_nociception2.86418680
6MP0009046_muscle_twitch2.76552342
7MP0002734_abnormal_mechanical_nocicepti2.61666645
8MP0002735_abnormal_chemical_nociception2.56616168
9MP0009745_abnormal_behavioral_response2.55622737
10MP0002063_abnormal_learning/memory/cond2.51664674
11MP0002064_seizures2.50929774
12MP0005423_abnormal_somatic_nervous2.42543010
13MP0001486_abnormal_startle_reflex2.41942132
14MP0002272_abnormal_nervous_system2.27439386
15MP0002572_abnormal_emotion/affect_behav2.26973802
16MP0004858_abnormal_nervous_system2.24505193
17MP0002736_abnormal_nociception_after2.24494452
18MP0000778_abnormal_nervous_system2.23279734
19MP0002733_abnormal_thermal_nociception2.02233595
20MP0003122_maternal_imprinting1.95171064
21MP0002184_abnormal_innervation1.94935958
22MP0001984_abnormal_olfaction1.87864484
23MP0002067_abnormal_sensory_capabilities1.86224733
24MP0001970_abnormal_pain_threshold1.79318332
25MP0006276_abnormal_autonomic_nervous1.78004918
26MP0005394_taste/olfaction_phenotype1.76236970
27MP0005499_abnormal_olfactory_system1.76236970
28MP0003787_abnormal_imprinting1.74177600
29MP0002653_abnormal_ependyma_morphology1.68729325
30MP0000955_abnormal_spinal_cord1.65807365
31MP0010030_abnormal_orbit_morphology1.65716395
32MP0003937_abnormal_limbs/digits/tail_de1.63960478
33MP0001440_abnormal_grooming_behavior1.61899005
34MP0002557_abnormal_social/conspecific_i1.61425609
35MP0002822_catalepsy1.59017974
36MP0003941_abnormal_skin_development1.56004013
37MP0004885_abnormal_endolymph1.54536548
38MP0000049_abnormal_middle_ear1.51884338
39MP0002882_abnormal_neuron_morphology1.48115251
40MP0004142_abnormal_muscle_tone1.43412386
41MP0005551_abnormal_eye_electrophysiolog1.42338232
42MP0002697_abnormal_eye_size1.41448985
43MP0001501_abnormal_sleep_pattern1.39200572
44MP0004811_abnormal_neuron_physiology1.37673529
45MP0003329_amyloid_beta_deposits1.37264675
46MP0008569_lethality_at_weaning1.33279974
47MP0005187_abnormal_penis_morphology1.31544613
48MP0000566_synostosis1.30830056
49MP0004924_abnormal_behavior1.30736978
50MP0005386_behavior/neurological_phenoty1.30736978
51MP0001293_anophthalmia1.28484192
52MP0005646_abnormal_pituitary_gland1.25027740
53MP0003942_abnormal_urinary_system1.23477890
54MP0002066_abnormal_motor_capabilities/c1.22717519
55MP0002938_white_spotting1.22163604
56MP0009780_abnormal_chondrocyte_physiolo1.21530558
57MP0006292_abnormal_olfactory_placode1.21431955
58MP0002752_abnormal_somatic_nervous1.19350450
59MP0003385_abnormal_body_wall1.17392245
60MP0003755_abnormal_palate_morphology1.16880542
61MP0002152_abnormal_brain_morphology1.14395000
62MP0003123_paternal_imprinting1.13336378
63MP0003137_abnormal_impulse_conducting1.12171988
64MP0003121_genomic_imprinting1.08590411
65MP0001286_abnormal_eye_development1.08075156
66MP0002229_neurodegeneration1.06640555
67MP0002909_abnormal_adrenal_gland1.03743556
68MP0003935_abnormal_craniofacial_develop1.03351768
69MP0000631_abnormal_neuroendocrine_gland1.02520633
70MP0003567_abnormal_fetal_cardiomyocyte1.01906082
71MP0008789_abnormal_olfactory_epithelium1.01007875
72MP0004272_abnormal_basement_membrane1.00456158
73MP0004085_abnormal_heartbeat0.99978572
74MP0003136_yellow_coat_color0.98985015
75MP0001177_atelectasis0.98563081
76MP0003634_abnormal_glial_cell0.96385363
77MP0001188_hyperpigmentation0.95876870
78MP0010368_abnormal_lymphatic_system0.94812151
79MP0005645_abnormal_hypothalamus_physiol0.94738760
80MP0001502_abnormal_circadian_rhythm0.93642979
81MP0001485_abnormal_pinna_reflex0.93391677
82MP0003632_abnormal_nervous_system0.92983709
83MP0003890_abnormal_embryonic-extraembry0.92812882
84MP0003861_abnormal_nervous_system0.92364125
85MP0001346_abnormal_lacrimal_gland0.92079073
86MP0001963_abnormal_hearing_physiology0.92037411
87MP0004742_abnormal_vestibular_system0.90239795
88MP0000428_abnormal_craniofacial_morphol0.90160570
89MP0001905_abnormal_dopamine_level0.89169336
90MP0003633_abnormal_nervous_system0.89052682
91MP0006072_abnormal_retinal_apoptosis0.88096035
92MP0002638_abnormal_pupillary_reflex0.87141659
93MP0002084_abnormal_developmental_patter0.86578066
94MP0003631_nervous_system_phenotype0.86107447
95MP0002751_abnormal_autonomic_nervous0.85987177
96MP0000920_abnormal_myelination0.85690501
97MP0002249_abnormal_larynx_morphology0.84989055
98MP0001529_abnormal_vocalization0.84624992
99MP0003938_abnormal_ear_development0.84212678
100MP0000579_abnormal_nail_morphology0.83713933
101MP0002116_abnormal_craniofacial_bone0.83163349
102MP0000462_abnormal_digestive_system0.82034290
103MP0002081_perinatal_lethality0.81775424
104MP0005253_abnormal_eye_physiology0.81693717
105MP0003879_abnormal_hair_cell0.81573827
106MP0003283_abnormal_digestive_organ0.81515306
107MP0003011_delayed_dark_adaptation0.81308315
108MP0002254_reproductive_system_inflammat0.80459843
109MP0002069_abnormal_eating/drinking_beha0.80002218
110MP0000537_abnormal_urethra_morphology0.79838713
111MP0004145_abnormal_muscle_electrophysio0.79143695
112MP0010386_abnormal_urinary_bladder0.79135784
113MP0009703_decreased_birth_body0.79002629
114MP0002234_abnormal_pharynx_morphology0.78958346
115MP0000026_abnormal_inner_ear0.78869071
116MP0009672_abnormal_birth_weight0.76997647
117MP0000751_myopathy0.76833879
118MP0004215_abnormal_myocardial_fiber0.76734634
119MP0000432_abnormal_head_morphology0.76513251
120MP0005257_abnormal_intraocular_pressure0.75913657
121MP0005248_abnormal_Harderian_gland0.75863064
122MP0003315_abnormal_perineum_morphology0.74971908
123MP0003690_abnormal_glial_cell0.74769835
124MP0005195_abnormal_posterior_eye0.73358323
125MP0005623_abnormal_meninges_morphology0.72204760
126MP0008872_abnormal_physiological_respon0.71130044
127MP0004133_heterotaxia0.70356911
128MP0002090_abnormal_vision0.70053545
129MP0002332_abnormal_exercise_endurance0.68456660
130MP0002233_abnormal_nose_morphology0.67619324
131MP0001943_abnormal_respiration0.67009492
132MP0001299_abnormal_eye_distance/0.66861353
133MP0000534_abnormal_ureter_morphology0.64769838
134MP0003119_abnormal_digestive_system0.63288194

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.26190117
2Myokymia (HP:0002411)4.46734191
3Febrile seizures (HP:0002373)4.37956455
4Focal seizures (HP:0007359)4.32631175
5Epileptic encephalopathy (HP:0200134)4.19234425
6Atonic seizures (HP:0010819)3.82233410
7Progressive cerebellar ataxia (HP:0002073)3.64467805
8Hyperventilation (HP:0002883)3.53525027
9Abnormality of the lower motor neuron (HP:0002366)3.41507021
10Action tremor (HP:0002345)3.22322465
11Termporal pattern (HP:0011008)3.18039178
12Insidious onset (HP:0003587)3.18039178
13Abnormality of the corticospinal tract (HP:0002492)3.16672985
14Dialeptic seizures (HP:0011146)3.10082776
15Absence seizures (HP:0002121)3.07137550
16Generalized tonic-clonic seizures (HP:0002069)2.92299462
17Supranuclear gaze palsy (HP:0000605)2.73352907
18Hepatoblastoma (HP:0002884)2.65914141
19Amblyopia (HP:0000646)2.64164573
20Bilateral microphthalmos (HP:0007633)2.63633563
21Visual hallucinations (HP:0002367)2.62001222
22Ankle clonus (HP:0011448)2.61266165
23Hemiparesis (HP:0001269)2.57369587
24Dysdiadochokinesis (HP:0002075)2.54999676
25Excessive salivation (HP:0003781)2.50899987
26Drooling (HP:0002307)2.50899987
27Neurofibrillary tangles (HP:0002185)2.50069248
28Spastic gait (HP:0002064)2.47890712
29Septo-optic dysplasia (HP:0100842)2.42664186
30Urinary bladder sphincter dysfunction (HP:0002839)2.32583773
31Broad-based gait (HP:0002136)2.26860205
32Gaze-evoked nystagmus (HP:0000640)2.22535536
33Dysmetria (HP:0001310)2.21774324
34Megalencephaly (HP:0001355)2.20271458
35Failure to thrive in infancy (HP:0001531)2.18180592
36Cortical dysplasia (HP:0002539)2.16661917
37Cerebral inclusion bodies (HP:0100314)2.16389133
38Lower limb muscle weakness (HP:0007340)2.16310891
39Degeneration of the lateral corticospinal tracts (HP:0002314)2.15449085
40Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.15449085
41Aplasia/Hypoplasia of the sternum (HP:0006714)2.12059010
42Bronchomalacia (HP:0002780)2.11746317
43Intestinal atresia (HP:0011100)2.11453516
44Cutaneous syndactyly (HP:0012725)2.10901362
45Pheochromocytoma (HP:0002666)2.10031885
46Impaired vibration sensation in the lower limbs (HP:0002166)2.08703622
47Status epilepticus (HP:0002133)2.08582556
48Scanning speech (HP:0002168)2.07571670
49Absent speech (HP:0001344)2.06890523
50Sensory axonal neuropathy (HP:0003390)2.06702130
51Genetic anticipation (HP:0003743)2.04141650
52Renal hypoplasia (HP:0000089)2.03807785
53Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.03612378
54Limb dystonia (HP:0002451)2.03310742
55Aplasia involving bones of the extremities (HP:0009825)2.02642714
56Aplasia involving bones of the upper limbs (HP:0009823)2.02642714
57Aplasia of the phalanges of the hand (HP:0009802)2.02642714
58Abnormal eating behavior (HP:0100738)2.02140920
59Epileptiform EEG discharges (HP:0011182)2.01382390
60Optic nerve hypoplasia (HP:0000609)2.00112407
61Choanal stenosis (HP:0000452)1.98565726
62EEG with generalized epileptiform discharges (HP:0011198)1.98371153
63Ulnar claw (HP:0001178)1.95119348
64Specific learning disability (HP:0001328)1.94721160
65Alacrima (HP:0000522)1.94631806
66Thyroid-stimulating hormone excess (HP:0002925)1.91651059
67Depression (HP:0000716)1.90950488
68Intention tremor (HP:0002080)1.90429607
69Coronal craniosynostosis (HP:0004440)1.89676014
70Generalized hypotonia (HP:0001290)1.89365886
71Amyotrophic lateral sclerosis (HP:0007354)1.88893682
72Preaxial foot polydactyly (HP:0001841)1.88548515
73Truncal ataxia (HP:0002078)1.88281782
74Turricephaly (HP:0000262)1.88169146
75Vitreoretinal degeneration (HP:0000655)1.87909272
76Hypochromic microcytic anemia (HP:0004840)1.87449783
77Papillary thyroid carcinoma (HP:0002895)1.86165768
78Steppage gait (HP:0003376)1.86054847
79Hypsarrhythmia (HP:0002521)1.85316757
80Ventricular fibrillation (HP:0001663)1.84802717
81Labial hypoplasia (HP:0000066)1.84740054
82Thickened helices (HP:0000391)1.84504454
83Gait imbalance (HP:0002141)1.83162800
84Postural instability (HP:0002172)1.81862879
85Abnormality of the astrocytes (HP:0100707)1.80982815
86Astrocytoma (HP:0009592)1.80982815
87Generalized myoclonic seizures (HP:0002123)1.78910371
88Impaired social interactions (HP:0000735)1.78901271
89Abnormal social behavior (HP:0012433)1.78901271
90Anophthalmia (HP:0000528)1.78307127
91Morphological abnormality of the pyramidal tract (HP:0002062)1.77661804
92Bifid tongue (HP:0010297)1.75786081
93Poor eye contact (HP:0000817)1.74776025
94Midline defect of the nose (HP:0004122)1.74374206
95Shallow orbits (HP:0000586)1.72820979
96Cutaneous finger syndactyly (HP:0010554)1.72207870
97Abnormality of the diencephalon (HP:0010662)1.71527780
98Urinary urgency (HP:0000012)1.70732444
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70059464
100Gastrointestinal atresia (HP:0002589)1.69125056
101Genital tract atresia (HP:0001827)1.68347266
102Hypoplastic female external genitalia (HP:0012815)1.67081295
103Agitation (HP:0000713)1.67037695
104Colon cancer (HP:0003003)1.66420707
105Cupped ear (HP:0000378)1.66142774
106Split foot (HP:0001839)1.65928831
107Torticollis (HP:0000473)1.64823683
108Abnormality of salivation (HP:0100755)1.64350567
109Onion bulb formation (HP:0003383)1.64095135
110Neuroendocrine neoplasm (HP:0100634)1.63977312
111Vaginal atresia (HP:0000148)1.63557137
112Neoplasm of the heart (HP:0100544)1.63550557
113Impaired vibratory sensation (HP:0002495)1.63532189
114Anomalous pulmonary venous return (HP:0010772)1.63529007
115Anxiety (HP:0000739)1.63337751
116Abnormality of the antihelix (HP:0009738)1.63313287
117Abnormality of the aortic arch (HP:0012303)1.61875298
118Broad metatarsal (HP:0001783)1.61689006
119Abnormality of pain sensation (HP:0010832)1.61184860
120Impaired pain sensation (HP:0007328)1.61184860
121Exotropia (HP:0000577)1.61183564
122Hemiplegia (HP:0002301)1.61062339
123Decreased lacrimation (HP:0000633)1.60463374
124Abnormality of the labia minora (HP:0012880)1.60410550
125Ependymoma (HP:0002888)1.58992009
126Hammertoe (HP:0001765)1.58069785
127Polyphagia (HP:0002591)1.57464218
128Micropenis (HP:0000054)1.57320036
129Neonatal short-limb short stature (HP:0008921)1.56786988
130Spastic paraplegia (HP:0001258)1.56618109
131Central scotoma (HP:0000603)1.56458258
132Protruding tongue (HP:0010808)1.55858523
133Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.55795472
134Short 4th metacarpal (HP:0010044)1.55795472
135Glioma (HP:0009733)1.55564957
136Bradycardia (HP:0001662)1.54378399
137Vertebral arch anomaly (HP:0008438)1.54346741
138Paraplegia (HP:0010550)1.54243125
139Horizontal nystagmus (HP:0000666)1.53957792
140Morphological abnormality of the middle ear (HP:0008609)1.53906848
141Lissencephaly (HP:0001339)1.53495280
142Partial duplication of thumb phalanx (HP:0009944)1.52806500
143Aqueductal stenosis (HP:0002410)1.52691301
144Inability to walk (HP:0002540)1.52463087
145Volvulus (HP:0002580)1.52250983
146Absent eyebrow (HP:0002223)1.51024149
147Absent septum pellucidum (HP:0001331)1.50866444
148Scrotal hypoplasia (HP:0000046)1.50546780
149Hypoplastic labia majora (HP:0000059)1.50023435
150Esophageal atresia (HP:0002032)1.49820937
151Nephronophthisis (HP:0000090)1.49141624
152Abnormality of the ischium (HP:0003174)1.49044070
153Abnormality of the middle phalanges of the toes (HP:0010183)1.45922147
154Supernumerary spleens (HP:0009799)1.44628539
155Pancreatic fibrosis (HP:0100732)1.43262983
156Abnormality of the pubic bones (HP:0003172)1.42998953
157Omphalocele (HP:0001539)1.42443828
158Pachygyria (HP:0001302)1.42020551
159Myelomeningocele (HP:0002475)1.41715236
160Shawl scrotum (HP:0000049)1.41705448
161Retinal dysplasia (HP:0007973)1.41457473
162Bifid scrotum (HP:0000048)1.41238390
163Chorioretinal atrophy (HP:0000533)1.41138022
164Neoplasm of the oral cavity (HP:0100649)1.40787926
165Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.40704047
166Sleep apnea (HP:0010535)1.40342220
167True hermaphroditism (HP:0010459)1.40205450
168Abnormality of the labia (HP:0000058)1.39243711

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.50824375
2MARK13.15316298
3EPHA42.96221266
4MAP3K92.68111586
5MAP3K42.63242686
6CASK2.59644715
7GRK52.48804931
8NTRK22.31718048
9PAK62.17458602
10WNK32.11671997
11NTRK12.07744998
12MAP2K72.04850257
13MINK12.00441384
14MAP2K41.97950867
15DAPK21.89297449
16STK38L1.67955652
17AKT31.61584212
18TYRO31.59027801
19LATS11.58742965
20MKNK21.58284415
21PNCK1.49229652
22TNIK1.48851114
23STK391.48781344
24LATS21.46103085
25WNK11.41747487
26MAPK131.41521553
27OXSR11.41126906
28LMTK21.40876484
29SGK4941.35325594
30SGK2231.35325594
31PHKG11.33789026
32PHKG21.33789026
33PRPF4B1.31786145
34BCR1.31734614
35CDK51.30228108
36STK381.28844189
37UHMK11.23972357
38TSSK61.16341611
39PLK21.15722043
40PAK31.15117564
41FGFR21.14424994
42CAMK1D1.12383274
43MKNK11.09934942
44TRIM281.07305490
45CDK121.05384263
46FGFR11.05279404
47KSR21.04957319
48SGK21.02367237
49FRK1.02216572
50CDC71.01527410
51PRKCG1.01504696
52KSR11.01076253
53TTK0.99351643
54PRKD30.99212464
55DMPK0.96061394
56CAMK2A0.94795774
57MARK20.93837645
58ADRBK20.91533644
59FER0.91371711
60PDGFRA0.90493927
61ERBB40.90314082
62ICK0.90214090
63SRPK10.88226439
64DYRK1A0.87805914
65CDK180.85381821
66CDK150.85178530
67CSNK1G10.84816147
68EPHB20.84565532
69PKN10.83069853
70CDK140.82995605
71GRK10.82908122
72CDC42BPA0.79611647
73CAMK40.79546193
74MAPK150.79295120
75SIK20.78902217
76CSNK1G20.77701590
77CDK190.77059413
78CAMK1G0.75792071
79BMPR1B0.74481919
80CAMK2B0.74336767
81SGK30.73153298
82PLK30.72781138
83STK110.72364632
84CAMKK10.71736042
85CDK11A0.71136568
86WEE10.71122618
87RET0.69417649
88TIE10.68961000
89LIMK10.68840132
90GRK70.67878891
91ADRBK10.67597765
92CAMK2D0.66420828
93EPHA30.64940194
94PRKCE0.62597513
95PIK3CA0.61140444
96CAMK10.59808744
97DYRK30.59768224
98TAF10.59618927
99BRD40.59520098
100ROCK20.58912042
101STK30.58785384
102MET0.57958346
103DYRK20.57390396
104CAMK2G0.56673749
105PRKCZ0.55411450
106NEK20.53817372
107SGK10.53281312
108ERBB20.52988803
109MAPK70.52792817
110NEK60.52351412
111ERBB30.52091345
112PRKAA10.51344134
113PRKDC0.51207897
114PINK10.50909624
115DDR20.50324100
116PRKCH0.50230601
117CSNK1A1L0.49394406
118CSNK1G30.49309408
119ROCK10.48831935
120ZAK0.48012307
121PAK20.47932437
122CDK30.47898843
123RPS6KA30.47126785
124MAP3K70.46784655
125PLK10.46723275
126MAPK100.45509322
127CSNK1E0.44807375
128DAPK10.44219987
129CSNK1D0.43494025
130FGR0.42577889
131PTK20.42343596
132MAP3K20.40383906
133PRKACA0.39503874
134MAP2K60.39186625
135PRKACB0.38589365
136WNK40.38313873
137PRKG10.37680124

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.48572477
2Synaptic vesicle cycle_Homo sapiens_hsa047212.84526562
3GABAergic synapse_Homo sapiens_hsa047272.74890787
4Glutamatergic synapse_Homo sapiens_hsa047242.37066301
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.36394895
6Circadian entrainment_Homo sapiens_hsa047132.20656883
7Morphine addiction_Homo sapiens_hsa050322.12884314
8Olfactory transduction_Homo sapiens_hsa047402.08430391
9Taste transduction_Homo sapiens_hsa047421.94760442
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88021701
11Long-term potentiation_Homo sapiens_hsa047201.81654394
12Salivary secretion_Homo sapiens_hsa049701.77422661
13Dopaminergic synapse_Homo sapiens_hsa047281.72970300
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70324220
15Insulin secretion_Homo sapiens_hsa049111.67511026
16Amphetamine addiction_Homo sapiens_hsa050311.64690149
17Serotonergic synapse_Homo sapiens_hsa047261.58320003
18Axon guidance_Homo sapiens_hsa043601.53078344
19Nitrogen metabolism_Homo sapiens_hsa009101.52752008
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50412510
21Long-term depression_Homo sapiens_hsa047301.49607932
22Cholinergic synapse_Homo sapiens_hsa047251.47517218
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41423934
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40916350
25Gastric acid secretion_Homo sapiens_hsa049711.40596708
26Renin secretion_Homo sapiens_hsa049241.36871720
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33438625
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32628936
29Adherens junction_Homo sapiens_hsa045201.31120922
30Cocaine addiction_Homo sapiens_hsa050301.28132154
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24158654
32Oxytocin signaling pathway_Homo sapiens_hsa049211.24146626
33Calcium signaling pathway_Homo sapiens_hsa040201.24107939
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19099829
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17868277
36Selenocompound metabolism_Homo sapiens_hsa004501.16796501
37Propanoate metabolism_Homo sapiens_hsa006401.16224738
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15993015
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15957863
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15952658
41GnRH signaling pathway_Homo sapiens_hsa049121.15208613
42Gap junction_Homo sapiens_hsa045401.13230061
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11963459
44Collecting duct acid secretion_Homo sapiens_hsa049661.11791818
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10393849
46Cardiac muscle contraction_Homo sapiens_hsa042601.09059183
47cAMP signaling pathway_Homo sapiens_hsa040241.08948063
48Melanogenesis_Homo sapiens_hsa049161.08490253
49Butanoate metabolism_Homo sapiens_hsa006501.08053470
50ErbB signaling pathway_Homo sapiens_hsa040121.01049667
51Bile secretion_Homo sapiens_hsa049760.99924684
52Phototransduction_Homo sapiens_hsa047440.97972619
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.97822014
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97261562
55Lysine degradation_Homo sapiens_hsa003100.96404653
56Dorso-ventral axis formation_Homo sapiens_hsa043200.96147801
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95313680
58Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91257543
59Dilated cardiomyopathy_Homo sapiens_hsa054140.89295203
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87834711
61TGF-beta signaling pathway_Homo sapiens_hsa043500.85067731
62Type II diabetes mellitus_Homo sapiens_hsa049300.83349006
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83344897
64beta-Alanine metabolism_Homo sapiens_hsa004100.83128419
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.82895918
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.82180155
67Hedgehog signaling pathway_Homo sapiens_hsa043400.81483900
68Histidine metabolism_Homo sapiens_hsa003400.81005775
69Estrogen signaling pathway_Homo sapiens_hsa049150.80275148
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79954021
71mRNA surveillance pathway_Homo sapiens_hsa030150.79077652
72Vitamin B6 metabolism_Homo sapiens_hsa007500.78532367
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76931683
74ECM-receptor interaction_Homo sapiens_hsa045120.76568722
75Basal cell carcinoma_Homo sapiens_hsa052170.76159002
76Retinol metabolism_Homo sapiens_hsa008300.75199005
77Pyruvate metabolism_Homo sapiens_hsa006200.75198690
78Arginine biosynthesis_Homo sapiens_hsa002200.74690167
79Glioma_Homo sapiens_hsa052140.74380108
80Arginine and proline metabolism_Homo sapiens_hsa003300.73111062
81Basal transcription factors_Homo sapiens_hsa030220.71760772
82Choline metabolism in cancer_Homo sapiens_hsa052310.70486105
83Protein digestion and absorption_Homo sapiens_hsa049740.70235037
84Wnt signaling pathway_Homo sapiens_hsa043100.69562415
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69126626
86Pancreatic secretion_Homo sapiens_hsa049720.68434938
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67277239
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66744911
89Ovarian steroidogenesis_Homo sapiens_hsa049130.66165719
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64606641
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64366499
92Fatty acid biosynthesis_Homo sapiens_hsa000610.63346994
93Ras signaling pathway_Homo sapiens_hsa040140.62856357
94Vibrio cholerae infection_Homo sapiens_hsa051100.61213523
95Ether lipid metabolism_Homo sapiens_hsa005650.61139350
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59997917
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59081679
98Fatty acid degradation_Homo sapiens_hsa000710.58847062
99* Rap1 signaling pathway_Homo sapiens_hsa040150.58076973
100Fat digestion and absorption_Homo sapiens_hsa049750.57967157
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.57760486
102* Tight junction_Homo sapiens_hsa045300.57535738
103Endometrial cancer_Homo sapiens_hsa052130.57333550
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.57046971
105Fatty acid metabolism_Homo sapiens_hsa012120.56950758
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56013583
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55334829
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55198243
109AMPK signaling pathway_Homo sapiens_hsa041520.54176723
110Thyroid hormone synthesis_Homo sapiens_hsa049180.53890824
111Hippo signaling pathway_Homo sapiens_hsa043900.53704187
112MAPK signaling pathway_Homo sapiens_hsa040100.53564772
113Caffeine metabolism_Homo sapiens_hsa002320.53464734
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53191610
115Protein export_Homo sapiens_hsa030600.52454778
116Linoleic acid metabolism_Homo sapiens_hsa005910.51989711
117MicroRNAs in cancer_Homo sapiens_hsa052060.51462485
118Tryptophan metabolism_Homo sapiens_hsa003800.49455247
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.49285734
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47281318
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.46669736
122Inositol phosphate metabolism_Homo sapiens_hsa005620.44697424
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44102345
124Steroid biosynthesis_Homo sapiens_hsa001000.42573683
125Fatty acid elongation_Homo sapiens_hsa000620.42127810
126mTOR signaling pathway_Homo sapiens_hsa041500.39740695
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39483016
128Renal cell carcinoma_Homo sapiens_hsa052110.39330668
129Circadian rhythm_Homo sapiens_hsa047100.38964814
130Oocyte meiosis_Homo sapiens_hsa041140.38580000
131Melanoma_Homo sapiens_hsa052180.37220831
132Glucagon signaling pathway_Homo sapiens_hsa049220.34492125
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34224675
134Mineral absorption_Homo sapiens_hsa049780.34078743
135Prion diseases_Homo sapiens_hsa050200.33212807
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.32304440
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30455778

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