MAGI3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)4.84584236
2cell communication involved in cardiac conduction (GO:0086065)4.26355324
3cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.74152889
4regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.66079595
5limb bud formation (GO:0060174)3.65177574
6ventricular cardiac muscle cell action potential (GO:0086005)3.62674725
7dendritic spine morphogenesis (GO:0060997)3.61669345
8regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.44343092
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.34643212
10cell communication by electrical coupling (GO:0010644)3.30311256
11presynaptic membrane assembly (GO:0097105)3.25844109
12pyrimidine nucleobase catabolic process (GO:0006208)3.23035653
13retinal ganglion cell axon guidance (GO:0031290)3.19365373
14regulation of heart rate by cardiac conduction (GO:0086091)3.17782351
15positive regulation of cardiac muscle hypertrophy (GO:0010613)3.17124518
16positive regulation of muscle hypertrophy (GO:0014742)3.17124518
17positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.13315586
18cardiac conduction (GO:0061337)3.11488617
19vocalization behavior (GO:0071625)3.07637737
20plasma membrane repair (GO:0001778)3.03313290
21embryonic retina morphogenesis in camera-type eye (GO:0060059)3.00469450
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.97259814
23presynaptic membrane organization (GO:0097090)2.96624198
24cardiac myofibril assembly (GO:0055003)2.93984038
25cardiac muscle cell action potential (GO:0086001)2.90645106
26activation of protein kinase A activity (GO:0034199)2.89879990
27neuron recognition (GO:0008038)2.89401304
28regulation of axon guidance (GO:1902667)2.86790154
29axonal fasciculation (GO:0007413)2.86453456
30negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.85763101
31regulation of axon extension involved in axon guidance (GO:0048841)2.85239899
32cardiac muscle cell action potential involved in contraction (GO:0086002)2.84794105
33membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.83995025
34nucleobase catabolic process (GO:0046113)2.81946163
35regulation of cardiac muscle cell contraction (GO:0086004)2.78340394
36regulation of actin filament-based movement (GO:1903115)2.77913151
37protein localization to synapse (GO:0035418)2.76768789
38negative regulation of axon guidance (GO:1902668)2.74129029
39regulation of membrane repolarization (GO:0060306)2.73079038
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.70730663
41negative regulation of axon extension involved in axon guidance (GO:0048843)2.68731687
42regulation of cell communication by electrical coupling (GO:0010649)2.67463017
43sarcomere organization (GO:0045214)2.66941744
44cardiac muscle contraction (GO:0060048)2.66224789
45regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.65427713
46embryonic foregut morphogenesis (GO:0048617)2.63815006
47cellular sodium ion homeostasis (GO:0006883)2.63568451
48neurotransmitter-gated ion channel clustering (GO:0072578)2.62972515
49negative regulation of potassium ion transmembrane transport (GO:1901380)2.61250703
50regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.59438850
51regulation of relaxation of muscle (GO:1901077)2.59099562
52relaxation of cardiac muscle (GO:0055119)2.57461813
53cardiac muscle hypertrophy (GO:0003300)2.57317010
54membrane repolarization during action potential (GO:0086011)2.56662344
55regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.55587337
56glutamate secretion (GO:0014047)2.54448324
57carnitine shuttle (GO:0006853)2.53106751
58fatty acid transmembrane transport (GO:1902001)2.52248124
59camera-type eye morphogenesis (GO:0048593)2.48744500
60central nervous system projection neuron axonogenesis (GO:0021952)2.48630135
61dicarboxylic acid biosynthetic process (GO:0043650)2.47973056
62regulation of cAMP-dependent protein kinase activity (GO:2000479)2.47083044
63dorsal/ventral axis specification (GO:0009950)2.45986152
64membrane repolarization (GO:0086009)2.45726068
65auditory receptor cell differentiation (GO:0042491)2.45247411
66postsynaptic membrane organization (GO:0001941)2.44460439
67positive regulation of gastrulation (GO:2000543)2.43993897
68synaptic vesicle docking involved in exocytosis (GO:0016081)2.43899798
69striated muscle hypertrophy (GO:0014897)2.43685891
70surfactant homeostasis (GO:0043129)2.42433259
71regulation of short-term neuronal synaptic plasticity (GO:0048172)2.42143099
72neuronal ion channel clustering (GO:0045161)2.41242960
73inner ear receptor stereocilium organization (GO:0060122)2.41014000
74chemical homeostasis within a tissue (GO:0048875)2.40719056
75regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.39883501
76positive regulation of potassium ion transmembrane transport (GO:1901381)2.38361102
77actomyosin structure organization (GO:0031032)2.37992374
78establishment of nucleus localization (GO:0040023)2.37984831
79epithelial cilium movement (GO:0003351)2.37582402
80kidney morphogenesis (GO:0060993)2.37120940
81cytoplasmic mRNA processing body assembly (GO:0033962)2.37055246
82negative regulation of keratinocyte proliferation (GO:0010839)2.36863499
83somite rostral/caudal axis specification (GO:0032525)2.36364245
84auditory behavior (GO:0031223)2.35802756
85central nervous system neuron axonogenesis (GO:0021955)2.35696789
86appendage development (GO:0048736)2.34972071
87limb development (GO:0060173)2.34972071
88calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.34909141
89alanine transport (GO:0032328)2.34650943
90myofibril assembly (GO:0030239)2.34490960
91phospholipid homeostasis (GO:0055091)2.33852758
92synaptic vesicle maturation (GO:0016188)2.32919797
93sodium ion export (GO:0071436)2.32805510
94regulation of cardioblast differentiation (GO:0051890)2.32395969
95positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.32155557
96regulation of heart rate (GO:0002027)2.31461752
97apical protein localization (GO:0045176)2.31104012
98cytoskeletal anchoring at plasma membrane (GO:0007016)2.31083969
99behavioral response to nicotine (GO:0035095)2.30940686
100locomotory exploration behavior (GO:0035641)2.30095146
101transmission of nerve impulse (GO:0019226)2.30029457
102proline transport (GO:0015824)2.29692407
103reverse cholesterol transport (GO:0043691)2.29647200
104insulin-like growth factor receptor signaling pathway (GO:0048009)2.29210521
105hindbrain development (GO:0030902)2.27735843
106regulation of cardiac muscle contraction (GO:0055117)2.26496056
107otic vesicle formation (GO:0030916)2.26009171
108dendritic spine organization (GO:0097061)2.24867564
109triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.24662619
110negative regulation of sodium ion transport (GO:0010766)2.23841411
111high-density lipoprotein particle remodeling (GO:0034375)2.23772893
112muscle hypertrophy (GO:0014896)2.23369059
113endocardial cushion development (GO:0003197)2.23353451
114negative regulation of activin receptor signaling pathway (GO:0032926)2.22322603
115positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.21182971
116layer formation in cerebral cortex (GO:0021819)2.21103871
117neuron cell-cell adhesion (GO:0007158)2.20941462
118regulation of the force of heart contraction (GO:0002026)2.20812770
119startle response (GO:0001964)2.20596030
120cilium movement (GO:0003341)2.20416235
121desmosome organization (GO:0002934)2.20294321
122synapse assembly (GO:0007416)2.19713952
123negative regulation of dendrite morphogenesis (GO:0050774)2.18961537
124negative regulation of cytosolic calcium ion concentration (GO:0051481)2.17911172
125cerebral cortex radially oriented cell migration (GO:0021799)2.17131179
126regulation of cardiac muscle hypertrophy (GO:0010611)2.17054743
127lysine metabolic process (GO:0006553)2.17044099
128lysine catabolic process (GO:0006554)2.17044099
129positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.16784711
130detection of calcium ion (GO:0005513)2.16113694
131positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.15786145
132action potential (GO:0001508)2.15510682
133cell migration in hindbrain (GO:0021535)2.14304683
134olfactory bulb development (GO:0021772)2.14160659
135glomerulus development (GO:0032835)2.14031873
136regulation of synapse assembly (GO:0051963)2.13738680
137regulation of hippo signaling (GO:0035330)2.12941383
138innervation (GO:0060384)2.12917363
139cellular potassium ion homeostasis (GO:0030007)2.12839802
140genitalia morphogenesis (GO:0035112)2.12800491
141multicellular organismal signaling (GO:0035637)2.12762442
142membrane depolarization during action potential (GO:0086010)2.12623624
143cardiac muscle adaptation (GO:0014887)2.12345821
144cardiac muscle hypertrophy in response to stress (GO:0014898)2.12345821
145muscle hypertrophy in response to stress (GO:0003299)2.12345821
146positive regulation of heart rate (GO:0010460)2.12300228
147positive regulation of synapse assembly (GO:0051965)2.11946494
148axon extension involved in axon guidance (GO:0048846)2.11778660
149neuron projection extension involved in neuron projection guidance (GO:1902284)2.11778660
150protein targeting to Golgi (GO:0000042)2.11671768
151neuronal action potential (GO:0019228)2.11472869
152nucleus localization (GO:0051647)2.11220011
153negative regulation of protein activation cascade (GO:2000258)2.09649574
154asymmetric protein localization (GO:0008105)2.09623396
155regulation of sarcomere organization (GO:0060297)2.09581474
156alpha-linolenic acid metabolic process (GO:0036109)2.08353878
157regulation of striated muscle contraction (GO:0006942)2.08322862
158atrial cardiac muscle cell action potential (GO:0086014)2.08278073
159dendrite morphogenesis (GO:0048813)2.07927168
160regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.07912234
161homocysteine metabolic process (GO:0050667)2.07796699
162glucan catabolic process (GO:0009251)2.07559019
163regulation of potassium ion transmembrane transport (GO:1901379)2.07196039
164synapse organization (GO:0050808)2.06801345
165establishment of protein localization to Golgi (GO:0072600)2.06480051
166spinal cord development (GO:0021510)2.06285707
167phenol-containing compound catabolic process (GO:0019336)2.05004980
168inner ear receptor cell differentiation (GO:0060113)2.04672965
169embryonic pattern specification (GO:0009880)2.04608250
170regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.02688081
171neuronal action potential propagation (GO:0019227)2.02045835
172cilium assembly (GO:0042384)2.01891648
173nonmotile primary cilium assembly (GO:0035058)2.01728955
174regulation of mesoderm development (GO:2000380)2.01529801
175mechanosensory behavior (GO:0007638)2.01083841
176positive regulation of dendritic spine morphogenesis (GO:0061003)2.00822328
177ephrin receptor signaling pathway (GO:0048013)2.00400707
178retina layer formation (GO:0010842)1.99474679
179positive regulation of mitochondrial fission (GO:0090141)1.99464138
180cilium organization (GO:0044782)1.98696113
181central nervous system myelination (GO:0022010)1.97786071
182axon ensheathment in central nervous system (GO:0032291)1.97786071
183interkinetic nuclear migration (GO:0022027)1.96346410
184paraxial mesoderm development (GO:0048339)1.95461174
185behavioral response to ethanol (GO:0048149)1.95250095
186lateral sprouting from an epithelium (GO:0060601)1.94979143
187intraciliary transport (GO:0042073)1.94931873
188embryonic axis specification (GO:0000578)1.94690168
189cell migration involved in gastrulation (GO:0042074)1.94536955
190negative chemotaxis (GO:0050919)1.93793509
191cranial nerve morphogenesis (GO:0021602)1.93466001
192neuron migration (GO:0001764)1.93023886
193prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060521.92423161

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.65990168
2GBX2_23144817_ChIP-Seq_PC3_Human2.44084524
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39302193
4* CDX2_19796622_ChIP-Seq_MESCs_Mouse2.22627494
5CBX2_27304074_Chip-Seq_ESCs_Mouse2.17495130
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.06510029
7FUS_26573619_Chip-Seq_HEK293_Human2.05066098
8EP300_21415370_ChIP-Seq_HL-1_Mouse1.97770512
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.92228566
10EZH2_18974828_ChIP-Seq_MESCs_Mouse1.84928174
11RNF2_18974828_ChIP-Seq_MESCs_Mouse1.84928174
12* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.81237699
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.80242003
14AHR_22903824_ChIP-Seq_MCF-7_Human1.79674113
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.78603255
16VDR_22108803_ChIP-Seq_LS180_Human1.77012963
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74883645
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.73053982
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.71875190
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69977579
21RNF2_27304074_Chip-Seq_NSC_Mouse1.69657921
22ESR1_20079471_ChIP-ChIP_T-47D_Human1.68232366
23MTF2_20144788_ChIP-Seq_MESCs_Mouse1.65719031
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.64906328
25* EWS_26573619_Chip-Seq_HEK293_Human1.62828966
26IGF1R_20145208_ChIP-Seq_DFB_Human1.62677832
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.61279689
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60871284
29* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60450736
30* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59735313
31ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.59129291
32ARNT_22903824_ChIP-Seq_MCF-7_Human1.58562273
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58023476
34DROSHA_22980978_ChIP-Seq_HELA_Human1.55904350
35LXR_22158963_ChIP-Seq_LIVER_Mouse1.55021147
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.54808982
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.53726009
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51941314
39* SMAD4_21799915_ChIP-Seq_A2780_Human1.50718900
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50364915
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49501234
42* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.48169980
43BCAT_22108803_ChIP-Seq_LS180_Human1.42318016
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.42282671
45STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.39636057
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39303960
47* TCF4_18268006_ChIP-ChIP_LS174T_Human1.38447673
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.37224272
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34797228
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34721089
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34721089
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33103600
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31977173
54RNF2_27304074_Chip-Seq_ESCs_Mouse1.31249465
55RXR_22158963_ChIP-Seq_LIVER_Mouse1.29238326
56TP53_18474530_ChIP-ChIP_U2OS_Human1.29140989
57TAF15_26573619_Chip-Seq_HEK293_Human1.27907718
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27468116
59* ER_23166858_ChIP-Seq_MCF-7_Human1.26276701
60* STAT3_23295773_ChIP-Seq_U87_Human1.25653995
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24997522
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24735713
63FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24333094
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.24124683
65TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23840544
66* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22270369
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.22260804
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21592609
69* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21474290
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19948232
71P300_19829295_ChIP-Seq_ESCs_Human1.19452160
72AR_25329375_ChIP-Seq_VCAP_Human1.18358987
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.17501709
74* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17325323
75* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17325323
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16439880
77SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16289264
78* FOXA2_19822575_ChIP-Seq_HepG2_Human1.16155613
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16119366
80CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14115056
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.13991688
82TP53_16413492_ChIP-PET_HCT116_Human1.12918851
83* NANOG_18555785_Chip-Seq_ESCs_Mouse1.10154173
84* SMAD4_21741376_ChIP-Seq_HESCs_Human1.09362054
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.08937711
86* AR_19668381_ChIP-Seq_PC3_Human1.08743279
87WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08601685
88TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08013917
89TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07548518
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07444489
91CDX2_20551321_ChIP-Seq_CACO-2_Human1.07426526
92* CJUN_26792858_Chip-Seq_BT549_Human1.06860249
93RING1B_27294783_Chip-Seq_NPCs_Mouse1.06572710
94TCF4_22108803_ChIP-Seq_LS180_Human1.06450013
95BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06136604
96* TCF4_23295773_ChIP-Seq_U87_Human1.06093410
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05684189
98CBP_20019798_ChIP-Seq_JUKART_Human1.05684189
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05498578
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04701692
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04592977
102KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04204004
103LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03970065
104AR_21572438_ChIP-Seq_LNCaP_Human1.03189819
105* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01840426
106GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01413411
107CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00889456
108SALL1_21062744_ChIP-ChIP_HESCs_Human1.00024343
109SMAD3_21741376_ChIP-Seq_EPCs_Human0.99946205
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99632227
111* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97909458
112NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97891886
113PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97566287
114POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96346878
115UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95429421
116* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95329019
117TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95040317
118FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94988783
119* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94539632
120* ISL1_27105846_Chip-Seq_CPCs_Mouse0.93299343
121EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93183425
122PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93151662
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92609191
124TBX20_22080862_ChIP-Seq_HEART_Mouse0.92551032
125TBX20_22328084_ChIP-Seq_HEART_Mouse0.92551032
126RUNX2_22187159_ChIP-Seq_PCA_Human0.91310871
127PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.91243143
128REST_21632747_ChIP-Seq_MESCs_Mouse0.90489282
129* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90121717
130SMAD3_21741376_ChIP-Seq_HESCs_Human0.90074742
131ZNF274_21170338_ChIP-Seq_K562_Hela0.90019849

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.67985832
2MP0005085_abnormal_gallbladder_physiolo3.10663973
3MP0005360_urolithiasis3.06010381
4MP0002837_dystrophic_cardiac_calcinosis2.81141068
5MP0003890_abnormal_embryonic-extraembry2.80027614
6MP0002735_abnormal_chemical_nociception2.77048437
7MP0004084_abnormal_cardiac_muscle2.61813827
8MP0004215_abnormal_myocardial_fiber2.57322103
9MP0000566_synostosis2.56489733
10MP0003880_abnormal_central_pattern2.49344754
11MP0009780_abnormal_chondrocyte_physiolo2.48580948
12MP0000751_myopathy2.44969140
13MP0003252_abnormal_bile_duct2.41111527
14MP0005365_abnormal_bile_salt2.39036228
15MP0004859_abnormal_synaptic_plasticity2.27756487
16MP0000778_abnormal_nervous_system2.14753921
17MP0003705_abnormal_hypodermis_morpholog2.05752433
18MP0004858_abnormal_nervous_system2.03673193
19MP0001968_abnormal_touch/_nociception1.98607989
20MP0002972_abnormal_cardiac_muscle1.91512206
21MP0010368_abnormal_lymphatic_system1.83990854
22MP0000569_abnormal_digit_pigmentation1.83831578
23MP0005330_cardiomyopathy1.82822289
24MP0002138_abnormal_hepatobiliary_system1.79775610
25MP0005670_abnormal_white_adipose1.77191087
26MP0002736_abnormal_nociception_after1.75750904
27MP0008775_abnormal_heart_ventricle1.74240287
28MP0005167_abnormal_blood-brain_barrier1.74200120
29MP0003137_abnormal_impulse_conducting1.74122282
30MP0004484_altered_response_of1.73655955
31MP0009384_cardiac_valve_regurgitation1.72055374
32MP0005623_abnormal_meninges_morphology1.71808281
33MP0003045_fibrosis1.69515946
34MP0004130_abnormal_muscle_cell1.65804039
35MP0004085_abnormal_heartbeat1.63638364
36MP0006138_congestive_heart_failure1.63096949
37MP0004036_abnormal_muscle_relaxation1.61400488
38MP0003787_abnormal_imprinting1.57354266
39MP0010030_abnormal_orbit_morphology1.54929193
40MP0004270_analgesia1.53986833
41MP0002638_abnormal_pupillary_reflex1.52554049
42MP0004272_abnormal_basement_membrane1.50823237
43MP0005083_abnormal_biliary_tract1.50381776
44MP0010329_abnormal_lipoprotein_level1.50350693
45MP0002734_abnormal_mechanical_nocicepti1.47838969
46MP0008875_abnormal_xenobiotic_pharmacok1.46145844
47MP0002938_white_spotting1.46033893
48MP0003121_genomic_imprinting1.43955012
49MP0005423_abnormal_somatic_nervous1.43887120
50MP0001666_abnormal_nutrient_absorption1.43542958
51MP0001879_abnormal_lymphatic_vessel1.42753503
52MP0004133_heterotaxia1.41334144
53MP0000631_abnormal_neuroendocrine_gland1.40896094
54MP0004087_abnormal_muscle_fiber1.39061123
55MP0005620_abnormal_muscle_contractility1.38723801
56MP0003937_abnormal_limbs/digits/tail_de1.38382254
57MP0002733_abnormal_thermal_nociception1.38370653
58MP0004043_abnormal_pH_regulation1.37829220
59MP0003119_abnormal_digestive_system1.37670196
60MP0006072_abnormal_retinal_apoptosis1.36523493
61MP0000427_abnormal_hair_cycle1.34848949
62MP0005187_abnormal_penis_morphology1.33515464
63MP0001544_abnormal_cardiovascular_syste1.32481601
64MP0005385_cardiovascular_system_phenoty1.32481601
65MP0002102_abnormal_ear_morphology1.30317059
66MP0000955_abnormal_spinal_cord1.29708619
67MP0003868_abnormal_feces_composition1.29389528
68MP0005646_abnormal_pituitary_gland1.29291626
69MP0003635_abnormal_synaptic_transmissio1.29270744
70MP0008877_abnormal_DNA_methylation1.27683688
71MP0002557_abnormal_social/conspecific_i1.27611016
72MP0005551_abnormal_eye_electrophysiolog1.27474601
73MP0001485_abnormal_pinna_reflex1.26421307
74MP0004885_abnormal_endolymph1.22887255
75MP0000534_abnormal_ureter_morphology1.22800414
76MP0000462_abnormal_digestive_system1.22550237
77MP0004742_abnormal_vestibular_system1.21599503
78MP0003942_abnormal_urinary_system1.21386827
79MP0002751_abnormal_autonomic_nervous1.19865573
80MP0003283_abnormal_digestive_organ1.19254107
81MP0010630_abnormal_cardiac_muscle1.18859612
82MP0001984_abnormal_olfaction1.16350527
83MP0000749_muscle_degeneration1.15794299
84MP0008004_abnormal_stomach_pH1.15502561
85MP0001177_atelectasis1.13597639
86MP0005253_abnormal_eye_physiology1.11567057
87MP0004185_abnormal_adipocyte_glucose1.11312122
88MP0002876_abnormal_thyroid_physiology1.11197349
89MP0003861_abnormal_nervous_system1.10858180
90MP0006276_abnormal_autonomic_nervous1.10766676
91MP0002160_abnormal_reproductive_system1.09099405
92MP0002882_abnormal_neuron_morphology1.07845724
93MP0001970_abnormal_pain_threshold1.07453783
94MP0004924_abnormal_behavior1.04389581
95MP0005386_behavior/neurological_phenoty1.04389581
96MP0009046_muscle_twitch1.04349739
97MP0002752_abnormal_somatic_nervous1.03640419
98MP0000383_abnormal_hair_follicle1.03201423
99MP0002152_abnormal_brain_morphology1.01868200
100MP0006292_abnormal_olfactory_placode1.00133793
101MP0002234_abnormal_pharynx_morphology0.99473526
102MP0005666_abnormal_adipose_tissue0.98960412
103MP0003938_abnormal_ear_development0.98824542
104MP0002063_abnormal_learning/memory/cond0.98673395
105MP0000538_abnormal_urinary_bladder0.98310002
106MP0003122_maternal_imprinting0.97595439
107MP0001286_abnormal_eye_development0.96802442
108MP0010678_abnormal_skin_adnexa0.95896646
109MP0002295_abnormal_pulmonary_circulatio0.95611991
110MP0000516_abnormal_urinary_system0.95438635
111MP0005367_renal/urinary_system_phenotyp0.95438635
112MP0003755_abnormal_palate_morphology0.95272445
113MP0003646_muscle_fatigue0.95009436
114MP0002822_catalepsy0.94010486
115MP0001958_emphysema0.93946499
116MP0003935_abnormal_craniofacial_develop0.93815669
117MP0008057_abnormal_DNA_replication0.93622921
118MP0002233_abnormal_nose_morphology0.93357376
119MP0003385_abnormal_body_wall0.92506300
120MP0002697_abnormal_eye_size0.91044839
121MP0004510_myositis0.90132805
122MP0000647_abnormal_sebaceous_gland0.90131292
123MP0009745_abnormal_behavioral_response0.90069234
124MP0002269_muscular_atrophy0.89404837
125MP0009697_abnormal_copulation0.88874337
126MP0000026_abnormal_inner_ear0.88389465
127MP0001529_abnormal_vocalization0.88271070
128MP0002127_abnormal_cardiovascular_syste0.88147793
129MP0004782_abnormal_surfactant_physiolog0.87099991
130MP0002184_abnormal_innervation0.87013059
131MP0002168_other_aberrant_phenotype0.86392893
132MP0003567_abnormal_fetal_cardiomyocyte0.85598584
133MP0001188_hyperpigmentation0.85535378
134MP0005391_vision/eye_phenotype0.84747515
135MP0003300_gastrointestinal_ulcer0.84608330
136MP0010234_abnormal_vibrissa_follicle0.83806991
137MP0002928_abnormal_bile_duct0.83232432
138MP0005394_taste/olfaction_phenotype0.82949257
139MP0005499_abnormal_olfactory_system0.82949257
140MP0005195_abnormal_posterior_eye0.81944811
141MP0003091_abnormal_cell_migration0.81466437
142MP0000049_abnormal_middle_ear0.81064343
143MP0001440_abnormal_grooming_behavior0.80339988
144MP0001486_abnormal_startle_reflex0.80196170
145MP0005248_abnormal_Harderian_gland0.80036319
146MP0003115_abnormal_respiratory_system0.79969173
147MP0001293_anophthalmia0.79883941
148MP0005409_darkened_coat_color0.77316024
149MP0002118_abnormal_lipid_homeostasis0.75654735
150MP0005275_abnormal_skin_tensile0.74972197
151MP0001299_abnormal_eye_distance/0.74792490
152MP0005165_increased_susceptibility_to0.72770452
153MP0002896_abnormal_bone_mineralization0.72613347
154MP0000767_abnormal_smooth_muscle0.71613429
155MP0002909_abnormal_adrenal_gland0.71240013
156MP0002067_abnormal_sensory_capabilities0.71230239
157MP0003950_abnormal_plasma_membrane0.70940481
158MP0005645_abnormal_hypothalamus_physiol0.70504814
159MP0002108_abnormal_muscle_morphology0.70307757
160MP0002572_abnormal_emotion/affect_behav0.69945843
161MP0005171_absent_coat_pigmentation0.69651683
162MP0004883_abnormal_blood_vessel0.67584423
163MP0003828_pulmonary_edema0.67508091
164MP0000537_abnormal_urethra_morphology0.66780026
165MP0002272_abnormal_nervous_system0.66760391
166MP0008995_early_reproductive_senescence0.64773834
167MP0002064_seizures0.64379263
168MP0002128_abnormal_blood_circulation0.63451745

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.19869969
2Sudden death (HP:0001699)4.29643573
3Syncope (HP:0001279)3.87213771
4Atrial fibrillation (HP:0005110)3.82750797
5Primary atrial arrhythmia (HP:0001692)3.59699585
6Ventricular tachycardia (HP:0004756)3.45673321
7Supraventricular tachycardia (HP:0004755)3.28288346
8Supraventricular arrhythmia (HP:0005115)3.26677383
9Termporal pattern (HP:0011008)3.19581167
10Insidious onset (HP:0003587)3.19581167
11Hyporeflexia of lower limbs (HP:0002600)3.17522583
12Prolonged QT interval (HP:0001657)3.16785152
13Deep venous thrombosis (HP:0002625)2.91376797
14Febrile seizures (HP:0002373)2.87831687
15Volvulus (HP:0002580)2.86138322
16Asymmetry of the thorax (HP:0001555)2.82164471
17Intestinal atresia (HP:0011100)2.78408512
18Ventricular fibrillation (HP:0001663)2.71321558
19Intrahepatic cholestasis (HP:0001406)2.69233923
20Oligodactyly (hands) (HP:0001180)2.67437005
21Ventricular arrhythmia (HP:0004308)2.65370178
22Bundle branch block (HP:0011710)2.51170018
23Aqueductal stenosis (HP:0002410)2.50300541
24Palpitations (HP:0001962)2.48756107
25Pancreatic cysts (HP:0001737)2.44389619
26Double outlet right ventricle (HP:0001719)2.43668349
27Congenital malformation of the right heart (HP:0011723)2.43668349
28Midline defect of the nose (HP:0004122)2.43510312
29Lower limb amyotrophy (HP:0007210)2.39753441
30Bradycardia (HP:0001662)2.36779837
31Shawl scrotum (HP:0000049)2.34531332
32Drooling (HP:0002307)2.34147476
33Hypoalphalipoproteinemia (HP:0003233)2.34084706
34Pancreatic fibrosis (HP:0100732)2.34034828
35Genital tract atresia (HP:0001827)2.33983048
36Vaginal atresia (HP:0000148)2.33920552
37Pheochromocytoma (HP:0002666)2.33507100
38Abnormal pancreas size (HP:0012094)2.32123486
39Action tremor (HP:0002345)2.30056373
40Abnormal EKG (HP:0003115)2.28918896
41Facial shape deformation (HP:0011334)2.28360236
42Potter facies (HP:0002009)2.28360236
43Lipoatrophy (HP:0100578)2.27961739
44Abnormality of the calf musculature (HP:0001430)2.27128684
45Focal seizures (HP:0007359)2.23128227
46Hepatoblastoma (HP:0002884)2.21769493
47Distal lower limb amyotrophy (HP:0008944)2.21630395
48Epidermoid cyst (HP:0200040)2.20365459
49Papillary thyroid carcinoma (HP:0002895)2.19624656
50Cutaneous finger syndactyly (HP:0010554)2.17026822
51Abnormality of the nasal septum (HP:0000419)2.15835240
52Broad metatarsal (HP:0001783)2.14637776
53Increased connective tissue (HP:0009025)2.14426835
54Focal motor seizures (HP:0011153)2.14299136
55True hermaphroditism (HP:0010459)2.10820530
56Broad-based gait (HP:0002136)2.10634778
57Gait imbalance (HP:0002141)2.09327612
58Exotropia (HP:0000577)2.09097814
59Anophthalmia (HP:0000528)2.08583786
60Muscle fiber splitting (HP:0003555)2.07462290
61Heart block (HP:0012722)2.07103014
62Impaired pain sensation (HP:0007328)2.06972388
63Abnormality of pain sensation (HP:0010832)2.06972388
64Nephronophthisis (HP:0000090)2.04077769
65Medial flaring of the eyebrow (HP:0010747)2.04004377
66Atrioventricular block (HP:0001678)2.03904416
67Central scotoma (HP:0000603)2.03792430
68Labial hypoplasia (HP:0000066)2.03685102
69Abnormality of the renal medulla (HP:0100957)2.02576316
70Generalized tonic-clonic seizures (HP:0002069)2.00583389
71Subacute progressive viral hepatitis (HP:0006572)1.99947344
72Excessive salivation (HP:0003781)1.99841110
73Abnormality of the aortic arch (HP:0012303)1.97311533
74Mesomelia (HP:0003027)1.97164246
75Abnormal atrioventricular conduction (HP:0005150)1.96408555
76Esophageal varix (HP:0002040)1.95485974
77Cystic liver disease (HP:0006706)1.93744482
78Preaxial foot polydactyly (HP:0001841)1.93299308
79Calf muscle hypertrophy (HP:0008981)1.91987233
80Dilated cardiomyopathy (HP:0001644)1.91890291
81Abnormality of monocarboxylic acid metabolism (HP:0010996)1.91840635
82Thyroid carcinoma (HP:0002890)1.90994305
83Myokymia (HP:0002411)1.89838655
84Hypoglycemic coma (HP:0001325)1.88888022
85Esophageal atresia (HP:0002032)1.88412745
86Status epilepticus (HP:0002133)1.87836063
87Congenital primary aphakia (HP:0007707)1.87389997
88Abnormality of the common coagulation pathway (HP:0010990)1.84993600
89Enlarged penis (HP:0000040)1.83856842
90Oligodactyly (HP:0012165)1.83411933
91Long toe (HP:0010511)1.82964455
92Bifid tongue (HP:0010297)1.81790980
93Bicornuate uterus (HP:0000813)1.81625214
94Renal hypoplasia (HP:0000089)1.81269230
95Hypoplastic female external genitalia (HP:0012815)1.81119156
96Postural instability (HP:0002172)1.80933873
97Turricephaly (HP:0000262)1.80931902
98Abnormality of the labia minora (HP:0012880)1.80179359
99Cutaneous syndactyly (HP:0012725)1.79823139
100Atonic seizures (HP:0010819)1.79746726
101Lymphangioma (HP:0100764)1.79565566
102Neuroendocrine neoplasm (HP:0100634)1.79480883
103Absent radius (HP:0003974)1.79441728
104Molar tooth sign on MRI (HP:0002419)1.79161936
105Abnormality of midbrain morphology (HP:0002418)1.79161936
106Xanthomatosis (HP:0000991)1.78865193
107Nephrogenic diabetes insipidus (HP:0009806)1.78334924
108Progressive cerebellar ataxia (HP:0002073)1.78251769
109Ulnar claw (HP:0001178)1.77992561
110Abnormality of the lower motor neuron (HP:0002366)1.77974794
111Subaortic stenosis (HP:0001682)1.76948021
112Abnormality of the left ventricular outflow tract (HP:0011103)1.76948021
113Poor coordination (HP:0002370)1.75564481
114Gastrointestinal atresia (HP:0002589)1.75005437
115EMG: myopathic abnormalities (HP:0003458)1.74590552
116Distal lower limb muscle weakness (HP:0009053)1.74321629
117Exercise-induced muscle cramps (HP:0003710)1.73935018
118Abnormality of glutamine family amino acid metabolism (HP:0010902)1.73307629
119Sudden cardiac death (HP:0001645)1.73136767
120Hypoplastic labia majora (HP:0000059)1.73069157
121Abnormality of the astrocytes (HP:0100707)1.72638007
122Astrocytoma (HP:0009592)1.72638007
123Cerebral aneurysm (HP:0004944)1.72188228
124Exercise-induced myalgia (HP:0003738)1.71929222
125Hypolipoproteinemia (HP:0010981)1.71464003
126Aplasia/Hypoplasia of the sternum (HP:0006714)1.70352283
127Hyperventilation (HP:0002883)1.70187054
128Absent forearm bone (HP:0003953)1.69576206
129Aplasia involving forearm bones (HP:0009822)1.69576206
130Preaxial hand polydactyly (HP:0001177)1.69368220
131Hypoplastic ischia (HP:0003175)1.69232838
132Dysmetric saccades (HP:0000641)1.68366223
133Urinary bladder sphincter dysfunction (HP:0002839)1.67004320
134Progressive sensorineural hearing impairment (HP:0000408)1.66091693
135Macroorchidism (HP:0000053)1.65877207
136Hammertoe (HP:0001765)1.65766822
137Abnormality of the parathyroid morphology (HP:0011766)1.65572306
138Epileptic encephalopathy (HP:0200134)1.65476483
139Abnormality of the renal cortex (HP:0011035)1.65081242
140Cardiovascular calcification (HP:0011915)1.64574840
141Complement deficiency (HP:0004431)1.63539085
142Aplasia involving bones of the upper limbs (HP:0009823)1.63407644
143Aplasia of the phalanges of the hand (HP:0009802)1.63407644
144Aplasia involving bones of the extremities (HP:0009825)1.63407644
145Impaired vibration sensation in the lower limbs (HP:0002166)1.62240728
146Dysdiadochokinesis (HP:0002075)1.61126937
147Cortical dysplasia (HP:0002539)1.60456701
148Aortic aneurysm (HP:0004942)1.59467023
149Hemangiomatosis (HP:0007461)1.59164092
150Protruding tongue (HP:0010808)1.59045454
151Mixed hearing impairment (HP:0000410)1.59027861
152Gaze-evoked nystagmus (HP:0000640)1.59010642
153Resting tremor (HP:0002322)1.58806418
154Abnormality of the ischium (HP:0003174)1.58693112
155Mildly elevated creatine phosphokinase (HP:0008180)1.58328969
156Amblyopia (HP:0000646)1.58125374
157Impaired proprioception (HP:0010831)1.55385982
158Overgrowth (HP:0001548)1.55010678
159Hamartoma of the eye (HP:0010568)1.55001595
160Anencephaly (HP:0002323)1.54926560
161Tubulointerstitial nephritis (HP:0001970)1.54326063
162Sensorimotor neuropathy (HP:0007141)1.54252255
163Chronic hepatic failure (HP:0100626)1.53971118
164Hemiplegia (HP:0002301)1.53943284
165Supernumerary spleens (HP:0009799)1.53891535
166Abnormality of the labia majora (HP:0012881)1.53752668
167Hyperkalemia (HP:0002153)1.53184658
168Myotonia (HP:0002486)1.52837266
169Tubular atrophy (HP:0000092)1.52624997
170Aplasia/Hypoplasia of the tibia (HP:0005772)1.52547653
171Decreased circulating renin level (HP:0003351)1.52109944
172Optic nerve hypoplasia (HP:0000609)1.51761136
173Aplasia/Hypoplasia of the tongue (HP:0010295)1.47554295
174Abnormality of the labia (HP:0000058)1.45292994
175Abnormality of permanent molar morphology (HP:0011071)1.44224078
176Abnormality of the dental root (HP:0006486)1.44224078
177Taurodontia (HP:0000679)1.44224078
178Postaxial hand polydactyly (HP:0001162)1.43853530
179Chromsome breakage (HP:0040012)1.43485988
180Abnormality of the dental pulp (HP:0006479)1.43227660
181Megalencephaly (HP:0001355)1.42945946
182Cupped ear (HP:0000378)1.42389678
183Tubulointerstitial abnormality (HP:0001969)1.41464637
184Ectopic kidney (HP:0000086)1.41250869
185Glioma (HP:0009733)1.40494224
186Fair hair (HP:0002286)1.40323314
187Concave nail (HP:0001598)1.39963109
188Alacrima (HP:0000522)1.36682326

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK23.44854633
2TNIK2.57507821
3NTRK32.49281239
4FRK2.40974944
5PNCK2.39713770
6INSRR2.28748542
7BMPR1B2.19354605
8STK392.14355257
9ACVR1B2.10157225
10RIPK11.98842457
11MAP3K41.88370346
12WNK31.88184846
13MINK11.87631272
14DAPK21.79462839
15LATS21.76357935
16STK381.74008003
17MYLK1.65538083
18DMPK1.65360284
19PKN21.65058384
20PHKG21.63979392
21PHKG11.63979392
22TTN1.61968442
23MAPK131.59418737
24LATS11.58357472
25MAP2K71.58194402
26FER1.55191282
27CASK1.53943376
28EPHA41.47363455
29TIE11.46583886
30MARK11.41325320
31BCR1.39798872
32MAP3K91.35364129
33CAMK1G1.33415625
34SIK11.32232281
35DDR21.32141073
36MAP4K21.30835737
37MAP2K41.30311345
38WNK41.28731081
39CAMK1D1.26247523
40PIK3CA1.24001344
41OBSCN1.21301797
42PLK21.21286336
43BMX1.20716795
44TRIB31.20107638
45PTK61.20035172
46BRSK21.19757780
47OXSR11.19717607
48MKNK21.19289316
49MAP3K21.17975033
50PLK41.16692458
51PAK31.13872053
52PDK31.13399562
53PDK41.13399562
54RET1.12953847
55SGK21.12593012
56NTRK11.11282626
57STK38L1.10858305
58PRKD31.10807217
59PDGFRA1.10263495
60SGK31.10001452
61STK31.07924049
62MET1.06265641
63STK241.05060820
64FGFR21.01352571
65ROCK10.99661654
66TRIM280.97868652
67CAMKK10.95045766
68AKT30.93650582
69CAMK2A0.93102775
70MST1R0.92389491
71PAK60.92204391
72EPHB20.91067166
73CSNK1G20.88279995
74ERBB30.88188629
75PTK2B0.87303769
76CAMK2D0.87166395
77PRKCE0.87119135
78GRK10.86053200
79BRD40.83763406
80CDC42BPA0.83094587
81MAP3K70.82005119
82MAP2K10.78715736
83SGK2230.73810507
84SGK4940.73810507
85CDK80.73788595
86FGFR30.73000512
87ERBB40.72679826
88NEK90.71905796
89PRKCZ0.71055131
90PTK20.70700624
91TGFBR20.70062571
92CAMKK20.69206160
93PRKG20.67851811
94CSNK1G10.66641688
95PRKCG0.65749817
96PDK20.65512300
97CAMK2B0.65182787
98CAMK10.64640577
99MUSK0.64637765
100KSR20.64171043
101MAP3K120.64115419
102PRKD10.64078867
103NTRK20.63551439
104CDK50.62852011
105CAMK2G0.62489711
106AKT20.62429362
107PRKAA10.61881643
108GRK50.61721287
109WEE10.59884598
110NEK60.59626839
111PRKAA20.58873779
112SGK10.57714688
113ZAK0.57575161
114DYRK30.57437233
115STK110.57147195
116FGFR10.56793640
117DYRK20.56612992
118JAK10.56380569
119UHMK10.55130993
120PRKCH0.54696288
121MST40.54508436
122TRPM70.53961425
123PINK10.53472427
124NUAK10.53068781
125EPHA20.52864576
126PKN10.52582406
127CSNK1E0.51873625
128CAMK40.51744911
129PDGFRB0.51675290
130GSK3A0.49787952
131MAPK120.49520292
132MAPK150.48872297
133CSNK1G30.48431269
134CSNK1A1L0.48127484
135ERBB20.47670862
136KSR10.46332220
137RPS6KA20.45734326
138MAP3K60.45296114
139BRSK10.43939878
140PLK10.43929749
141PRKG10.43664043
142MELK0.42471884
143ATM0.41333364
144PRKCI0.41258023
145MKNK10.40882493
146PLK30.39872245
147TGFBR10.38858977

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.65448184
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.40153179
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99875640
4Arginine biosynthesis_Homo sapiens_hsa002201.95699645
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.84809220
6Bile secretion_Homo sapiens_hsa049761.84571651
7Maturity onset diabetes of the young_Homo sapiens_hsa049501.84241720
8Fatty acid degradation_Homo sapiens_hsa000711.80254531
9Primary bile acid biosynthesis_Homo sapiens_hsa001201.69162242
10Dilated cardiomyopathy_Homo sapiens_hsa054141.66257181
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.53522004
12Cocaine addiction_Homo sapiens_hsa050301.49246509
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.42818170
14Propanoate metabolism_Homo sapiens_hsa006401.39245841
15Fatty acid biosynthesis_Homo sapiens_hsa000611.38204473
16Fatty acid metabolism_Homo sapiens_hsa012121.38054791
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37710463
18Tryptophan metabolism_Homo sapiens_hsa003801.33519428
19Phototransduction_Homo sapiens_hsa047441.33111169
20Circadian rhythm_Homo sapiens_hsa047101.32942230
21Hippo signaling pathway_Homo sapiens_hsa043901.32538995
22Hedgehog signaling pathway_Homo sapiens_hsa043401.30374699
23PPAR signaling pathway_Homo sapiens_hsa033201.30025026
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29736459
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28530007
26Vitamin digestion and absorption_Homo sapiens_hsa049771.25418715
27Complement and coagulation cascades_Homo sapiens_hsa046101.21032274
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19491724
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18703533
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17885199
31Basal cell carcinoma_Homo sapiens_hsa052171.17440761
32Insulin secretion_Homo sapiens_hsa049111.17185152
33Dorso-ventral axis formation_Homo sapiens_hsa043201.16812631
34Olfactory transduction_Homo sapiens_hsa047401.16445563
35Linoleic acid metabolism_Homo sapiens_hsa005911.14955011
36Butanoate metabolism_Homo sapiens_hsa006501.14307596
37Salivary secretion_Homo sapiens_hsa049701.13400025
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13348424
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13063019
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.11639931
41Nicotine addiction_Homo sapiens_hsa050331.08965143
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06850566
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06405130
44Adherens junction_Homo sapiens_hsa045201.05532378
45Gastric acid secretion_Homo sapiens_hsa049711.04888598
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04325317
47Circadian entrainment_Homo sapiens_hsa047131.04302317
48Serotonergic synapse_Homo sapiens_hsa047261.01644251
49ABC transporters_Homo sapiens_hsa020101.00919398
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00046138
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98989783
52TGF-beta signaling pathway_Homo sapiens_hsa043500.98862696
53Synaptic vesicle cycle_Homo sapiens_hsa047210.98267969
54Steroid biosynthesis_Homo sapiens_hsa001000.97629615
55Starch and sucrose metabolism_Homo sapiens_hsa005000.96850224
56Type II diabetes mellitus_Homo sapiens_hsa049300.96540074
57GABAergic synapse_Homo sapiens_hsa047270.94929871
58Renin secretion_Homo sapiens_hsa049240.94134526
59Fanconi anemia pathway_Homo sapiens_hsa034600.93209874
60Vitamin B6 metabolism_Homo sapiens_hsa007500.92565970
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90112567
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.89000855
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.88241881
64Morphine addiction_Homo sapiens_hsa050320.88190312
65Taste transduction_Homo sapiens_hsa047420.86891007
66Glucagon signaling pathway_Homo sapiens_hsa049220.86577297
67beta-Alanine metabolism_Homo sapiens_hsa004100.86528611
68Glutamatergic synapse_Homo sapiens_hsa047240.86185975
69Wnt signaling pathway_Homo sapiens_hsa043100.84460616
70Calcium signaling pathway_Homo sapiens_hsa040200.84152338
71Cholinergic synapse_Homo sapiens_hsa047250.83608809
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83520955
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82101466
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82016332
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81947541
76Ether lipid metabolism_Homo sapiens_hsa005650.80579895
77Focal adhesion_Homo sapiens_hsa045100.80106583
78Long-term depression_Homo sapiens_hsa047300.80023999
79Cardiac muscle contraction_Homo sapiens_hsa042600.79026578
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77698977
81Fat digestion and absorption_Homo sapiens_hsa049750.75740571
82Chemical carcinogenesis_Homo sapiens_hsa052040.75515955
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75492274
84Long-term potentiation_Homo sapiens_hsa047200.75167269
85Insulin signaling pathway_Homo sapiens_hsa049100.74725133
86Histidine metabolism_Homo sapiens_hsa003400.73692305
87* Tight junction_Homo sapiens_hsa045300.72928541
88GnRH signaling pathway_Homo sapiens_hsa049120.72565406
89ECM-receptor interaction_Homo sapiens_hsa045120.72434097
90Oxytocin signaling pathway_Homo sapiens_hsa049210.72422476
91Gap junction_Homo sapiens_hsa045400.71249355
92Lysine degradation_Homo sapiens_hsa003100.71037961
93Mineral absorption_Homo sapiens_hsa049780.70729544
94Amoebiasis_Homo sapiens_hsa051460.69421514
95Thyroid hormone synthesis_Homo sapiens_hsa049180.69271790
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69215925
97Basal transcription factors_Homo sapiens_hsa030220.69210694
98cAMP signaling pathway_Homo sapiens_hsa040240.69180430
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.68248153
100Insulin resistance_Homo sapiens_hsa049310.67410730
101Glycerolipid metabolism_Homo sapiens_hsa005610.66828847
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66297033
103Endometrial cancer_Homo sapiens_hsa052130.66279073
104Dopaminergic synapse_Homo sapiens_hsa047280.66144726
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65818301
106Caffeine metabolism_Homo sapiens_hsa002320.64822528
107Glioma_Homo sapiens_hsa052140.63354793
108Axon guidance_Homo sapiens_hsa043600.60782213
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60774974
110Ovarian steroidogenesis_Homo sapiens_hsa049130.59477719
111Pyruvate metabolism_Homo sapiens_hsa006200.59006459
112Amphetamine addiction_Homo sapiens_hsa050310.58873444
113Oocyte meiosis_Homo sapiens_hsa041140.58822840
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58700824
115Estrogen signaling pathway_Homo sapiens_hsa049150.57699357
116Melanogenesis_Homo sapiens_hsa049160.57154336
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57153629
118Phenylalanine metabolism_Homo sapiens_hsa003600.56147605
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55290818
120Peroxisome_Homo sapiens_hsa041460.54833019
121Selenocompound metabolism_Homo sapiens_hsa004500.53715459
122* Rap1 signaling pathway_Homo sapiens_hsa040150.53490033
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53185435
124Proteoglycans in cancer_Homo sapiens_hsa052050.53112031
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52767986
126Retinol metabolism_Homo sapiens_hsa008300.52109269
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50771093
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49460681
129Viral myocarditis_Homo sapiens_hsa054160.48669141
130Protein digestion and absorption_Homo sapiens_hsa049740.48018073
131Melanoma_Homo sapiens_hsa052180.46744926
132Renin-angiotensin system_Homo sapiens_hsa046140.46704394
133Pancreatic secretion_Homo sapiens_hsa049720.46676950

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