MAGOH2P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive T cell selection (GO:0043368)5.41436082
2positive thymic T cell selection (GO:0045059)5.37239996
3regulation of glycogen (starch) synthase activity (GO:2000465)4.87333472
4positive regulation of Rap GTPase activity (GO:0032854)4.85036970
5nerve growth factor signaling pathway (GO:0038180)4.70061587
6positive regulation of vasculogenesis (GO:2001214)4.63563599
7negative regulation of neurotransmitter secretion (GO:0046929)4.61004302
8positive regulation of granulocyte differentiation (GO:0030854)4.23255361
9negative regulation of cell killing (GO:0031342)4.22747020
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.22747020
11regulation of Rap GTPase activity (GO:0032317)4.20733240
12negative thymic T cell selection (GO:0045060)4.12859372
13Rap protein signal transduction (GO:0032486)4.12676891
14embryonic process involved in female pregnancy (GO:0060136)4.09403692
15adaptation of signaling pathway (GO:0023058)4.06584437
16positive regulation of gamma-delta T cell activation (GO:0046645)4.05850453
17T cell selection (GO:0045058)4.04272348
18viral transcription (GO:0019083)4.02596410
19regulation of NFAT protein import into nucleus (GO:0051532)3.92375363
20negative T cell selection (GO:0043383)3.87740299
21negative regulation of T cell mediated immunity (GO:0002710)3.86525779
22thymic T cell selection (GO:0045061)3.83669060
23negative regulation of neurotransmitter transport (GO:0051589)3.83033630
24regulation of establishment of cell polarity (GO:2000114)3.82401347
25embryonic hemopoiesis (GO:0035162)3.79515059
26translational termination (GO:0006415)3.71086980
27histone H3-K4 trimethylation (GO:0080182)3.65365718
28negative regulation of cardiac muscle hypertrophy (GO:0010614)3.61958570
29rRNA methylation (GO:0031167)3.55234238
30definitive hemopoiesis (GO:0060216)3.54382935
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.54348744
32positive regulation of tolerance induction (GO:0002645)3.47947803
33response to nerve growth factor (GO:1990089)3.45557587
34cellular response to nerve growth factor stimulus (GO:1990090)3.45557587
35negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.40672880
36rRNA modification (GO:0000154)3.40447911
37activated T cell proliferation (GO:0050798)3.38253819
38mast cell degranulation (GO:0043303)3.31491509
39mast cell activation involved in immune response (GO:0002279)3.31491509
40megakaryocyte development (GO:0035855)3.30066009
41negative regulation of granulocyte differentiation (GO:0030853)3.29732785
42regulation of B cell receptor signaling pathway (GO:0050855)3.29456343
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.27132309
44negative regulation of muscle hypertrophy (GO:0014741)3.20365784
45phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.16730979
46mRNA splice site selection (GO:0006376)3.15646567
47regulation of granulocyte differentiation (GO:0030852)3.13670449
48C21-steroid hormone biosynthetic process (GO:0006700)3.11333672
49translational elongation (GO:0006414)3.09876181
50response to peptidoglycan (GO:0032494)3.07428356
51neurotransmitter biosynthetic process (GO:0042136)3.07000875
52eyelid development in camera-type eye (GO:0061029)3.06189016
53histone H3-K9 modification (GO:0061647)3.05206469
54regulation of gamma-delta T cell differentiation (GO:0045586)3.03452265
55regulation of gamma-delta T cell activation (GO:0046643)2.98131167
56energy homeostasis (GO:0097009)2.97903223
57cellular extravasation (GO:0045123)2.96873126
58purinergic nucleotide receptor signaling pathway (GO:0035590)2.95280106
59tyrosine phosphorylation of STAT protein (GO:0007260)2.94105338
60mast cell activation (GO:0045576)2.93001110
61tolerance induction (GO:0002507)2.92734228
62regulation of tolerance induction (GO:0002643)2.91120886
63positive regulation of protein homooligomerization (GO:0032464)2.90573008
64viral life cycle (GO:0019058)2.90018952
65B cell receptor signaling pathway (GO:0050853)2.88251532
66negative regulation of lymphocyte mediated immunity (GO:0002707)2.87153668
67nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.82415501
68negative regulation of glycoprotein biosynthetic process (GO:0010561)2.81626579
69establishment of endothelial barrier (GO:0061028)2.81200268
70cellular protein complex disassembly (GO:0043624)2.78582260
71response to interleukin-15 (GO:0070672)2.78300734
72negative regulation of interleukin-12 production (GO:0032695)2.77580740
73JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.77266662
74regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.77089476
75antigen processing and presentation of endogenous antigen (GO:0019883)2.76004910
76positive regulation by host of viral transcription (GO:0043923)2.75554115
77regulation of establishment or maintenance of cell polarity (GO:0032878)2.74717228
78negative regulation of erythrocyte differentiation (GO:0045647)2.72060129
79positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.70696107
80T cell migration (GO:0072678)2.69422596
81antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.66549858
82negative regulation of T-helper cell differentiation (GO:0045623)2.66087676
83negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.66087676
84negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.65344188
85negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.64574471
86granulocyte differentiation (GO:0030851)2.64475738
87neural tube formation (GO:0001841)2.64152231
88positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.64133394
89regulation of vasculogenesis (GO:2001212)2.61009623
90SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.60473931
91positive regulation of CREB transcription factor activity (GO:0032793)2.60344168
92regulation of B cell differentiation (GO:0045577)2.60047628
93regulation of synaptic vesicle exocytosis (GO:2000300)2.59681639
94CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.58481584
95positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.58171256
96negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.57525602
97detection of bacterium (GO:0016045)2.55516320
98cotranslational protein targeting to membrane (GO:0006613)2.55029530
99negative regulation of type 2 immune response (GO:0002829)2.52932852
100cilium or flagellum-dependent cell motility (GO:0001539)2.50803647

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.49710546
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.82113349
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.30467703
4GATA1_22025678_ChIP-Seq_K562_Human4.27608946
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.14957281
6RUNX_20019798_ChIP-Seq_JUKART_Human3.29301290
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.05056651
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.89922172
9SCL_19346495_ChIP-Seq_HPC-7_Human2.74328326
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.65671454
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.59234303
12MYB_26560356_Chip-Seq_TH2_Human2.58991872
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.56211417
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.43634888
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.42464188
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.36319417
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.35957467
18MYC_22102868_ChIP-Seq_BL_Human2.31877263
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.28302938
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.20500559
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.20115121
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04973996
23MYB_26560356_Chip-Seq_TH1_Human2.01606857
24ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.01576596
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.01501090
26UTX_26944678_Chip-Seq_JUKART_Human1.95214190
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.95024609
28TCF7_22412390_ChIP-Seq_EML_Mouse1.94251581
29SPI1_23547873_ChIP-Seq_NB4_Human1.93830875
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.84608052
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.77910142
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64813312
33MAF_26560356_Chip-Seq_TH1_Human1.62673146
34VDR_24763502_ChIP-Seq_THP-1_Human1.60350459
35RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.55873174
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55041277
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50876409
38MAF_26560356_Chip-Seq_TH2_Human1.48753602
39GATA3_27048872_Chip-Seq_THYMUS_Human1.44020401
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40991130
41GATA3_26560356_Chip-Seq_TH2_Human1.35945648
42GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33824334
43SPI1_23127762_ChIP-Seq_K562_Human1.27227690
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26625122
45CIITA_25753668_ChIP-Seq_RAJI_Human1.25254759
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24058582
47KDM2B_26808549_Chip-Seq_DND41_Human1.23306913
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21824234
49KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.18359570
50KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.18359570
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.18359570
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.17958036
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17597365
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15111406
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14003253
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13384669
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12799986
58TAF15_26573619_Chip-Seq_HEK293_Human1.12218296
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09535598
60VDR_24787735_ChIP-Seq_THP-1_Human1.09303030
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07735099
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05716909
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04008339
64IRF1_19129219_ChIP-ChIP_H3396_Human1.03668760
65ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03019814
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02953895
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.00678891
68KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.00047385
69Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99270190
70PU_27001747_Chip-Seq_BMDM_Mouse0.97687336
71STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97265806
72VDR_21846776_ChIP-Seq_THP-1_Human0.96059958
73TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.94122116
74IRF8_21731497_ChIP-ChIP_J774_Mouse0.93616758
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93041069
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92343627
77KDM2B_26808549_Chip-Seq_JURKAT_Human0.91509217
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91501821
79GATA1_19941826_ChIP-Seq_K562_Human0.91369220
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90450628
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90090047
82SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89997707
83SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89369014
84TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89075154
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87685773
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84357512
87DPY_21335234_ChIP-Seq_ESCs_Mouse0.84313659
88GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84080188
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82725010
90CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82505859
91EWS_26573619_Chip-Seq_HEK293_Human0.81718626
92CBX2_27304074_Chip-Seq_ESCs_Mouse0.80614405
93OCT4_21477851_ChIP-Seq_ESCs_Mouse0.78756553
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78528500
95ETV2_25802403_ChIP-Seq_MESCs_Mouse0.78479945
96FUS_26573619_Chip-Seq_HEK293_Human0.77074570
97GATA1_19941827_ChIP-Seq_MEL_Mouse0.76901132
98RBPJ_22232070_ChIP-Seq_NCS_Mouse0.76722588
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.76361145
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.75186646

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ8.40827133
2MP0005451_abnormal_body_composition4.10795838
3MP0002396_abnormal_hematopoietic_system3.95331087
4MP0003724_increased_susceptibility_to3.69779132
5MP0008260_abnormal_autophagy3.27062896
6MP0009379_abnormal_foot_pigmentation2.95650514
7MP0001835_abnormal_antigen_presentation2.67564411
8MP0003436_decreased_susceptibility_to2.47797869
9MP0000685_abnormal_immune_system2.39734722
10MP0009278_abnormal_bone_marrow2.34704398
11MP0003763_abnormal_thymus_physiology2.34423454
12MP0005397_hematopoietic_system_phenotyp2.29334817
13MP0001545_abnormal_hematopoietic_system2.29334817
14MP0003880_abnormal_central_pattern2.24148281
15MP0001800_abnormal_humoral_immune2.09213058
16MP0001790_abnormal_immune_system1.98268085
17MP0005387_immune_system_phenotype1.98268085
18MP0004142_abnormal_muscle_tone1.97906988
19MP0005464_abnormal_platelet_physiology1.96615954
20MP0002166_altered_tumor_susceptibility1.86692229
21MP0002102_abnormal_ear_morphology1.84166322
22MP0001188_hyperpigmentation1.78263050
23MP0004808_abnormal_hematopoietic_stem1.76791304
24MP0005085_abnormal_gallbladder_physiolo1.75591937
25MP0002398_abnormal_bone_marrow1.67597982
26MP0000013_abnormal_adipose_tissue1.64677878
27MP0002723_abnormal_immune_serum1.62733496
28MP0005000_abnormal_immune_tolerance1.62635398
29MP0002420_abnormal_adaptive_immunity1.55303126
30MP0001819_abnormal_immune_cell1.52914556
31MP0004147_increased_porphyrin_level1.52755733
32MP0003252_abnormal_bile_duct1.50143999
33MP0002452_abnormal_antigen_presenting1.45744293
34MP0009333_abnormal_splenocyte_physiolog1.45463455
35MP0000689_abnormal_spleen_morphology1.44355410
36MP0005671_abnormal_response_to1.42907668
37MP0000703_abnormal_thymus_morphology1.42741784
38MP0002006_tumorigenesis1.39798394
39MP0003303_peritoneal_inflammation1.39280381
40MP0008877_abnormal_DNA_methylation1.39204711
41MP0005025_abnormal_response_to1.38471324
42MP0003828_pulmonary_edema1.38108340
43MP0000716_abnormal_immune_system1.36431690
44MP0009697_abnormal_copulation1.27901629
45MP0002009_preneoplasia1.24392667
46MP0002722_abnormal_immune_system1.21085204
47MP0009764_decreased_sensitivity_to1.19542059
48MP0002419_abnormal_innate_immunity1.16327015
49MP0003300_gastrointestinal_ulcer1.15803343
50MP0001533_abnormal_skeleton_physiology1.14281503
51MP0002148_abnormal_hypersensitivity_rea1.13554264
52MP0005409_darkened_coat_color1.09448938
53MP0005075_abnormal_melanosome_morpholog1.09067391
54MP0005535_abnormal_body_temperature1.04711033
55MP0002429_abnormal_blood_cell1.03262122
56MP0000015_abnormal_ear_pigmentation1.03246660
57MP0003878_abnormal_ear_physiology1.01581072
58MP0005377_hearing/vestibular/ear_phenot1.01581072
59MP0005310_abnormal_salivary_gland0.99486766
60MP0004484_altered_response_of0.93381027
61MP0003172_abnormal_lysosome_physiology0.93357287
62MP0001986_abnormal_taste_sensitivity0.90877490
63MP0006036_abnormal_mitochondrial_physio0.89729056
64MP0003221_abnormal_cardiomyocyte_apopto0.89208887
65MP0004084_abnormal_cardiac_muscle0.84727414
66MP0002405_respiratory_system_inflammati0.83267424
67MP0003866_abnormal_defecation0.77642183
68MP0010155_abnormal_intestine_physiology0.77385940
69MP0008873_increased_physiological_sensi0.77348491
70MP0005166_decreased_susceptibility_to0.75738030
71MP0009785_altered_susceptibility_to0.73409961
72MP0004134_abnormal_chest_morphology0.73394319
73MP0000465_gastrointestinal_hemorrhage0.71669639
74MP0003191_abnormal_cellular_cholesterol0.70834526
75MP0002108_abnormal_muscle_morphology0.70343770
76MP0008995_early_reproductive_senescence0.69285805
77MP0000249_abnormal_blood_vessel0.65741152
78MP0002998_abnormal_bone_remodeling0.64311919
79MP0004130_abnormal_muscle_cell0.63619023
80MP0000604_amyloidosis0.63543065
81MP0004947_skin_inflammation0.62448896
82MP0008872_abnormal_physiological_respon0.62136199
83MP0006276_abnormal_autonomic_nervous0.61455117
84MP0002019_abnormal_tumor_incidence0.59041409
85MP0001663_abnormal_digestive_system0.57327485
86MP0005174_abnormal_tail_pigmentation0.57086633
87MP0003959_abnormal_lean_body0.56958289
88MP0004883_abnormal_blood_vessel0.56955313
89MP0001727_abnormal_embryo_implantation0.56288862
90MP0006292_abnormal_olfactory_placode0.55939433
91MP0002269_muscular_atrophy0.55607315
92MP0001845_abnormal_inflammatory_respons0.54759052
93MP0005408_hypopigmentation0.53825848
94MP0000858_altered_metastatic_potential0.52980523
95MP0004885_abnormal_endolymph0.52974328
96MP0005381_digestive/alimentary_phenotyp0.52748924
97MP0009115_abnormal_fat_cell0.52331702
98MP0005448_abnormal_energy_balance0.49726044
99MP0001851_eye_inflammation0.49379246
100MP0005390_skeleton_phenotype0.49025152

Predicted human phenotypes

RankGene SetZ-score
1Type 2 muscle fiber atrophy (HP:0003554)7.34917021
2Stomatitis (HP:0010280)6.99229031
3Muscle fiber atrophy (HP:0100295)6.62836371
4Fatigable weakness (HP:0003473)5.02651605
5Abnormality of the neuromuscular junction (HP:0003398)5.02651605
6Weak cry (HP:0001612)4.98387400
7Papilledema (HP:0001085)4.38677561
8Increased IgM level (HP:0003496)4.08365888
9Elevated erythrocyte sedimentation rate (HP:0003565)4.06230140
10Prolonged bleeding time (HP:0003010)3.98211438
11Myositis (HP:0100614)3.85018876
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.82725274
13Panhypogammaglobulinemia (HP:0003139)3.55966072
14Bulbar palsy (HP:0001283)3.32396123
15Fatigue (HP:0012378)3.29810569
16Distal arthrogryposis (HP:0005684)3.17450727
17Abnormality of the phalanges of the 2nd finger (HP:0009541)3.01601615
18Poor suck (HP:0002033)2.99993252
19Pustule (HP:0200039)2.97595871
20Spinal cord lesions (HP:0100561)2.92253603
21Syringomyelia (HP:0003396)2.92253603
22Abnormality of the periventricular white matter (HP:0002518)2.88019480
23Acute myeloid leukemia (HP:0004808)2.83392746
24Epistaxis (HP:0000421)2.71519803
25Abnormality of T cell physiology (HP:0011840)2.70273344
26Abnormal number of erythroid precursors (HP:0012131)2.64371392
27Abnormality of cells of the erythroid lineage (HP:0012130)2.55223774
28Abnormality of the left ventricular outflow tract (HP:0011103)2.52750681
29Subaortic stenosis (HP:0001682)2.52750681
30Gastrointestinal infarctions (HP:0005244)2.52741271
31Abnormality of T cells (HP:0002843)2.51398570
32Gingival bleeding (HP:0000225)2.46238019
33Hypergammaglobulinemia (HP:0010702)2.43965051
34IgG deficiency (HP:0004315)2.40604612
35Intellectual disability, profound (HP:0002187)2.40481379
36Eczematoid dermatitis (HP:0000976)2.37508815
37Generalized hypotonia (HP:0001290)2.32332161
38Peritonitis (HP:0002586)2.27457350
39Spontaneous hematomas (HP:0007420)2.25465136
40Recurrent cutaneous fungal infections (HP:0011370)2.23988740
41Chronic mucocutaneous candidiasis (HP:0002728)2.23988740
42Degeneration of the lateral corticospinal tracts (HP:0002314)2.23558781
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.23558781
44Pallor (HP:0000980)2.20806512
45Polycythemia (HP:0001901)2.20138350
46Recurrent bacterial skin infections (HP:0005406)2.17758577
47Basal cell carcinoma (HP:0002671)2.17431062
48Facial diplegia (HP:0001349)2.15997124
49Meningitis (HP:0001287)2.15250269
50Macrocytic anemia (HP:0001972)2.14618513
51Mesomelia (HP:0003027)2.14127470
52Aortic aneurysm (HP:0004942)2.11772690
53Agammaglobulinemia (HP:0004432)2.10343067
54Frequent falls (HP:0002359)2.08417744
55Clonus (HP:0002169)2.07186445
56Abnormality of incisor morphology (HP:0011063)2.05303694
57Recurrent skin infections (HP:0001581)2.04490708
58Broad alveolar ridges (HP:0000187)2.01140753
59Thrombocytosis (HP:0001894)2.01075711
60Parakeratosis (HP:0001036)1.98578693
61Recurrent fungal infections (HP:0002841)1.98537590
62Abnormality of the 2nd finger (HP:0004100)1.95931884
63Leukocytosis (HP:0001974)1.95365523
64Rimmed vacuoles (HP:0003805)1.93200731
65Tapered finger (HP:0001182)1.91456526
66T lymphocytopenia (HP:0005403)1.85446077
67Narrow palate (HP:0000189)1.82581818
68Inflammation of the large intestine (HP:0002037)1.80977130
69Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77750147
70Recurrent abscess formation (HP:0002722)1.77294865
71Pulmonary embolism (HP:0002204)1.76234724
72Constricted visual fields (HP:0001133)1.76205436
73Abnormality of the epiphyses of the hand (HP:0005924)1.75960905
74Recurrent viral infections (HP:0004429)1.75751858
75Osteomyelitis (HP:0002754)1.73351736
76Stomach cancer (HP:0012126)1.70356275
77Encephalitis (HP:0002383)1.69946343
78IgM deficiency (HP:0002850)1.69283428
79Broad palm (HP:0001169)1.69214317
80Abnormal platelet function (HP:0011869)1.68589064
81Impaired platelet aggregation (HP:0003540)1.68589064
82Aplastic anemia (HP:0001915)1.68373951
83Abnormality of T cell number (HP:0011839)1.68114805
84Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.67356726
85Tinnitus (HP:0000360)1.67340090
86Respiratory insufficiency due to muscle weakness (HP:0002747)1.66988677
87Mediastinal lymphadenopathy (HP:0100721)1.65964863
88Disproportionate short-trunk short stature (HP:0003521)1.65656551
89Submucous cleft hard palate (HP:0000176)1.65100552
90Capillary hemangiomas (HP:0005306)1.64684407
91Respiratory distress (HP:0002098)1.63904023
92Gastrointestinal inflammation (HP:0004386)1.63219705
93Chest pain (HP:0100749)1.63001063
94Papilloma (HP:0012740)1.62876916
95Verrucae (HP:0200043)1.62876916
96Vasculitis (HP:0002633)1.61934652
97Retrobulbar optic neuritis (HP:0100654)1.60220448
98Optic neuritis (HP:0100653)1.60220448
99Lower limb asymmetry (HP:0100559)1.57981597
100Neutropenia (HP:0001875)1.57812738

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK35.04577966
2SIK13.91392126
3TAOK33.55263095
4SIK23.36982956
5MAP3K63.13696323
6PRPF4B2.73903456
7MAP4K12.65125892
8JAK32.55389022
9DYRK32.42515084
10MAP3K42.39644679
11PIK3CG2.36004138
12AKT31.98085453
13MAP3K101.97886817
14MARK31.88806134
15RIPK41.88800612
16PRKCH1.69746287
17FGFR31.67075136
18SGK21.64544569
19MAP2K71.63819989
20MAP2K41.63329828
21ZAK1.50681242
22PASK1.39616909
23TXK1.35568403
24CDK61.23931574
25IKBKE1.23490766
26ADRBK21.14494154
27MAP3K131.11768136
28IRAK41.11502186
29KIT1.10749058
30ITK1.08548316
31MAPKAPK31.07959538
32CSNK1G31.06789336
33FES1.05004529
34PRKD21.03375661
35SGK4940.98062906
36SGK2230.98062906
37IRAK10.96373661
38SGK30.95485059
39TYRO30.94360718
40PINK10.93564619
41CCNB10.92916879
42RPS6KC10.91611957
43RPS6KL10.91611957
44JAK10.91320928
45FRK0.88923621
46RPS6KA60.86809410
47CSNK1G20.86120673
48MARK20.85443973
49HIPK20.84327211
50DAPK20.83370291
51MAP2K30.81802303
52SYK0.81447518
53TYK20.81120994
54MAP3K140.81083604
55KSR20.78729434
56BTK0.76608044
57RPS6KA20.75309272
58LCK0.71605963
59PTK60.70150740
60CSNK1G10.69951825
61UHMK10.69383752
62MAP3K50.68896969
63CSNK1A1L0.67761246
64BRD40.67309165
65CSK0.64687861
66TEC0.63419876
67JAK20.63148627
68MAPK150.62206641
69HCK0.59422803
70ZAP700.59148304
71MATK0.59032907
72KSR10.58433144
73LYN0.58373261
74GRK60.57376281
75MAP3K20.54832218
76IKBKB0.54377002
77CSF1R0.53755838
78BMPR20.53243006
79LATS10.52198446
80PRKCG0.51864768
81PRKCE0.51246494
82TBK10.48746640
83MAP2K10.48462001
84STK38L0.46437853
85MAPK120.44691966
86OBSCN0.43376946
87PIM10.41903852
88TAF10.41331676
89DYRK1B0.39643877
90MKNK10.39259520
91STK380.38303130
92PRKCD0.37363143
93STK240.36873094
94MAPK70.35723163
95TRPM70.35433554
96TGFBR10.35140208
97MAP3K70.34201943
98EPHB20.33932650
99BLK0.31410140
100CAMK40.30193324

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053102.79038117
2Allograft rejection_Homo sapiens_hsa053302.78568173
3Autoimmune thyroid disease_Homo sapiens_hsa053202.71235602
4Primary immunodeficiency_Homo sapiens_hsa053402.39893992
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.22828730
6Leishmaniasis_Homo sapiens_hsa051402.22531558
7B cell receptor signaling pathway_Homo sapiens_hsa046622.22000498
8Selenocompound metabolism_Homo sapiens_hsa004502.15249721
9Ribosome_Homo sapiens_hsa030102.12333771
10Graft-versus-host disease_Homo sapiens_hsa053322.07003186
11T cell receptor signaling pathway_Homo sapiens_hsa046601.87599156
12Regulation of autophagy_Homo sapiens_hsa041401.85685563
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.81942894
14Platelet activation_Homo sapiens_hsa046111.75804934
15Long-term potentiation_Homo sapiens_hsa047201.70203906
16Dorso-ventral axis formation_Homo sapiens_hsa043201.65083023
17Staphylococcus aureus infection_Homo sapiens_hsa051501.60958320
18Osteoclast differentiation_Homo sapiens_hsa043801.58298122
19Viral myocarditis_Homo sapiens_hsa054161.57560137
20Acute myeloid leukemia_Homo sapiens_hsa052211.54639109
21Type I diabetes mellitus_Homo sapiens_hsa049401.47341681
22Toxoplasmosis_Homo sapiens_hsa051451.42597451
23Measles_Homo sapiens_hsa051621.42195699
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41548712
25Colorectal cancer_Homo sapiens_hsa052101.33867401
26Prolactin signaling pathway_Homo sapiens_hsa049171.33673774
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.33179696
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33104586
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32729360
30Tuberculosis_Homo sapiens_hsa051521.31840597
31Linoleic acid metabolism_Homo sapiens_hsa005911.31797571
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28300533
33Influenza A_Homo sapiens_hsa051641.28229011
34Chemokine signaling pathway_Homo sapiens_hsa040621.23209440
35Pancreatic cancer_Homo sapiens_hsa052121.21654654
36Hematopoietic cell lineage_Homo sapiens_hsa046401.21055834
37Glycerophospholipid metabolism_Homo sapiens_hsa005641.17351582
38Neurotrophin signaling pathway_Homo sapiens_hsa047221.17092145
39Herpes simplex infection_Homo sapiens_hsa051681.16490440
40Antigen processing and presentation_Homo sapiens_hsa046121.14598993
41Renal cell carcinoma_Homo sapiens_hsa052111.13332271
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.08994709
43Arachidonic acid metabolism_Homo sapiens_hsa005901.05116844
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98175676
45Long-term depression_Homo sapiens_hsa047300.97878137
46Non-small cell lung cancer_Homo sapiens_hsa052230.96485815
47Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95770959
48Notch signaling pathway_Homo sapiens_hsa043300.93886172
49MAPK signaling pathway_Homo sapiens_hsa040100.93012650
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86930621
51Cholinergic synapse_Homo sapiens_hsa047250.86266515
52Chronic myeloid leukemia_Homo sapiens_hsa052200.86078418
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85000559
54Endometrial cancer_Homo sapiens_hsa052130.81539850
55Renin secretion_Homo sapiens_hsa049240.80457683
56Malaria_Homo sapiens_hsa051440.78731591
57Hepatitis C_Homo sapiens_hsa051600.77046284
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76797022
59TNF signaling pathway_Homo sapiens_hsa046680.75770010
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74838161
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74581914
62Hepatitis B_Homo sapiens_hsa051610.74218883
63mTOR signaling pathway_Homo sapiens_hsa041500.74197147
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74058386
65Oxytocin signaling pathway_Homo sapiens_hsa049210.72807204
66FoxO signaling pathway_Homo sapiens_hsa040680.72517426
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.72241108
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.68624131
69ErbB signaling pathway_Homo sapiens_hsa040120.68582472
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.68049537
71GnRH signaling pathway_Homo sapiens_hsa049120.67238311
72Choline metabolism in cancer_Homo sapiens_hsa052310.66122534
73HTLV-I infection_Homo sapiens_hsa051660.64500558
74VEGF signaling pathway_Homo sapiens_hsa043700.63103988
75Insulin resistance_Homo sapiens_hsa049310.61276537
76Amphetamine addiction_Homo sapiens_hsa050310.61178401
77Vitamin B6 metabolism_Homo sapiens_hsa007500.61000368
78African trypanosomiasis_Homo sapiens_hsa051430.59245577
79Shigellosis_Homo sapiens_hsa051310.57655634
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57318124
81Cocaine addiction_Homo sapiens_hsa050300.57109731
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55670238
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51372441
84Rheumatoid arthritis_Homo sapiens_hsa053230.51313508
85cAMP signaling pathway_Homo sapiens_hsa040240.49212500
86Epstein-Barr virus infection_Homo sapiens_hsa051690.48135586
87Gap junction_Homo sapiens_hsa045400.48111803
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47166450
89Type II diabetes mellitus_Homo sapiens_hsa049300.44064157
90Apoptosis_Homo sapiens_hsa042100.42887672
91Ras signaling pathway_Homo sapiens_hsa040140.42707018
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42088704
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.39677952
94Prostate cancer_Homo sapiens_hsa052150.39536464
95Inositol phosphate metabolism_Homo sapiens_hsa005620.38480820
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37163961
97Circadian rhythm_Homo sapiens_hsa047100.36419475
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35206740
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35056915
100Insulin signaling pathway_Homo sapiens_hsa049100.32684852

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