

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 6.71893240 |
| 2 | positive regulation of natural killer cell differentiation (GO:0032825) | 6.47275756 |
| 3 | regulation of protein glycosylation (GO:0060049) | 5.38480217 |
| 4 | DNA deamination (GO:0045006) | 4.79961967 |
| 5 | cellular response to interferon-alpha (GO:0035457) | 4.51390907 |
| 6 | fucose catabolic process (GO:0019317) | 4.50699461 |
| 7 | L-fucose metabolic process (GO:0042354) | 4.50699461 |
| 8 | L-fucose catabolic process (GO:0042355) | 4.50699461 |
| 9 | regulation of natural killer cell differentiation (GO:0032823) | 4.48412546 |
| 10 | signal peptide processing (GO:0006465) | 4.36901136 |
| 11 | platelet dense granule organization (GO:0060155) | 4.28324704 |
| 12 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.99483354 |
| 13 | regulation of interleukin-8 secretion (GO:2000482) | 3.66029444 |
| 14 | pericardium development (GO:0060039) | 3.61750273 |
| 15 | arginine catabolic process (GO:0006527) | 3.56735414 |
| 16 | vagina development (GO:0060068) | 3.45320020 |
| 17 | protein-cofactor linkage (GO:0018065) | 3.41317107 |
| 18 | positive regulation of interleukin-8 secretion (GO:2000484) | 3.39566288 |
| 19 | mesenchymal-epithelial cell signaling (GO:0060638) | 3.38256062 |
| 20 | response to interferon-alpha (GO:0035455) | 3.30855603 |
| 21 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.25381675 |
| 22 | anterograde synaptic vesicle transport (GO:0048490) | 3.25197874 |
| 23 | negative regulation of mast cell activation (GO:0033004) | 3.24001588 |
| 24 | rRNA modification (GO:0000154) | 3.22159658 |
| 25 | DNA double-strand break processing (GO:0000729) | 3.21810091 |
| 26 | negative regulation of axon extension involved in axon guidance (GO:0048843) | 3.21700081 |
| 27 | ATP synthesis coupled proton transport (GO:0015986) | 3.08073427 |
| 28 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.08073427 |
| 29 | ovulation cycle (GO:0042698) | 3.04189045 |
| 30 | preassembly of GPI anchor in ER membrane (GO:0016254) | 3.03938014 |
| 31 | negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518) | 3.02251687 |
| 32 | protein neddylation (GO:0045116) | 3.01984875 |
| 33 | regulation of ER to Golgi vesicle-mediated transport (GO:0060628) | 3.01284047 |
| 34 | positive regulation of vesicle fusion (GO:0031340) | 2.96774205 |
| 35 | dolichol-linked oligosaccharide biosynthetic process (GO:0006488) | 2.94708550 |
| 36 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.94121197 |
| 37 | termination of RNA polymerase III transcription (GO:0006386) | 2.94121197 |
| 38 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 2.90374844 |
| 39 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.87939656 |
| 40 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.87939656 |
| 41 | isotype switching (GO:0045190) | 2.87939656 |
| 42 | rRNA methylation (GO:0031167) | 2.86801134 |
| 43 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.83987738 |
| 44 | pseudouridine synthesis (GO:0001522) | 2.81757936 |
| 45 | negative regulation of axon guidance (GO:1902668) | 2.81579309 |
| 46 | respiratory chain complex IV assembly (GO:0008535) | 2.80761550 |
| 47 | endocrine hormone secretion (GO:0060986) | 2.80702100 |
| 48 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.76445400 |
| 49 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.76445400 |
| 50 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.76445400 |
| 51 | positive regulation of natural killer cell activation (GO:0032816) | 2.75949590 |
| 52 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class | 2.75547635 |
| 53 | water-soluble vitamin biosynthetic process (GO:0042364) | 2.73764151 |
| 54 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.73181639 |
| 55 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.73181639 |
| 56 | xenobiotic catabolic process (GO:0042178) | 2.72153649 |
| 57 | regulation of metalloenzyme activity (GO:0048552) | 2.68015323 |
| 58 | lens development in camera-type eye (GO:0002088) | 2.67618134 |
| 59 | glycerophospholipid catabolic process (GO:0046475) | 2.67023413 |
| 60 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.66382922 |
| 61 | female genitalia development (GO:0030540) | 2.65950691 |
| 62 | nucleotide-sugar biosynthetic process (GO:0009226) | 2.65742415 |
| 63 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.65454920 |
| 64 | branched-chain amino acid catabolic process (GO:0009083) | 2.64654622 |
| 65 | membrane raft organization (GO:0031579) | 2.63840952 |
| 66 | UMP metabolic process (GO:0046049) | 2.63382834 |
| 67 | pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173) | 2.63382834 |
| 68 | UMP biosynthetic process (GO:0006222) | 2.63382834 |
| 69 | pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174) | 2.63382834 |
| 70 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 2.62914375 |
| 71 | positive regulation of protein autophosphorylation (GO:0031954) | 2.62888017 |
| 72 | sulfation (GO:0051923) | 2.62011199 |
| 73 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 2.59823471 |
| 74 | double-strand break repair via homologous recombination (GO:0000724) | 2.59523151 |
| 75 | N-acetylglucosamine metabolic process (GO:0006044) | 2.58879509 |
| 76 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.58684505 |
| 77 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.58684505 |
| 78 | aldehyde catabolic process (GO:0046185) | 2.57820894 |
| 79 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.53771269 |
| 80 | recombinational repair (GO:0000725) | 2.52874851 |
| 81 | cytochrome complex assembly (GO:0017004) | 2.49537387 |
| 82 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.49007918 |
| 83 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.48903501 |
| 84 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.48488421 |
| 85 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.45798597 |
| 86 | 7-methylguanosine mRNA capping (GO:0006370) | 2.45471209 |
| 87 | negative regulation of signal transduction by p53 class mediator (GO:1901797) | 2.45403022 |
| 88 | protein K11-linked deubiquitination (GO:0035871) | 2.44738725 |
| 89 | cell wall macromolecule metabolic process (GO:0044036) | 2.43271855 |
| 90 | positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:0061081 | 2.43107190 |
| 91 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 2.42996929 |
| 92 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.42082858 |
| 93 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.42082858 |
| 94 | RNA capping (GO:0036260) | 2.40443325 |
| 95 | 7-methylguanosine RNA capping (GO:0009452) | 2.40443325 |
| 96 | positive regulation of steroid hormone secretion (GO:2000833) | 2.40434730 |
| 97 | UDP-N-acetylglucosamine metabolic process (GO:0006047) | 2.39283079 |
| 98 | inner mitochondrial membrane organization (GO:0007007) | 2.38350956 |
| 99 | tRNA processing (GO:0008033) | 2.38228603 |
| 100 | negative regulation of ligase activity (GO:0051352) | 2.37049314 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.68766367 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.43349571 |
| 3 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 3.31647170 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.14570154 |
| 5 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.07166988 |
| 6 | VDR_22108803_ChIP-Seq_LS180_Human | 2.97678540 |
| 7 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.87406526 |
| 8 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.80407608 |
| 9 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.79548857 |
| 10 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.44382171 |
| 11 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.40890753 |
| 12 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.35236615 |
| 13 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.32883614 |
| 14 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 2.26872579 |
| 15 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.16575563 |
| 16 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 2.08246050 |
| 17 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 2.02629032 |
| 18 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.98531263 |
| 19 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.95920584 |
| 20 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.94415085 |
| 21 | EWS_26573619_Chip-Seq_HEK293_Human | 1.85603809 |
| 22 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.81827210 |
| 23 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.79689346 |
| 24 | P300_19829295_ChIP-Seq_ESCs_Human | 1.74311554 |
| 25 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.73667155 |
| 26 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.71543785 |
| 27 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.70765461 |
| 28 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.62032169 |
| 29 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.61475885 |
| 30 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.61412733 |
| 31 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.61231159 |
| 32 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.60069721 |
| 33 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.55310171 |
| 34 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.54795933 |
| 35 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.54726823 |
| 36 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.53678713 |
| 37 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.53470599 |
| 38 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.52016079 |
| 39 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.50510261 |
| 40 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.46472633 |
| 41 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.46049634 |
| 42 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.43203328 |
| 43 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.43203328 |
| 44 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.40836738 |
| 45 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.40436916 |
| 46 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.40042898 |
| 47 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.39240707 |
| 48 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.38916994 |
| 49 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.35996635 |
| 50 | AR_20517297_ChIP-Seq_VCAP_Human | 1.35177064 |
| 51 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.32780102 |
| 52 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.32709133 |
| 53 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.31103535 |
| 54 | FUS_26573619_Chip-Seq_HEK293_Human | 1.31055450 |
| 55 | BRD4_25478319_ChIP-Seq_HGPS_Human | 1.29736519 |
| 56 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.26242317 |
| 57 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.26242317 |
| 58 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.26194754 |
| 59 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.25206930 |
| 60 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.25206930 |
| 61 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.23397951 |
| 62 | RBPJ_21746931_ChIP-Seq_IB4_Human | 1.22658073 |
| 63 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.22516875 |
| 64 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.21579010 |
| 65 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 1.21190190 |
| 66 | GATA3_26560356_Chip-Seq_TH2_Human | 1.21106919 |
| 67 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.20463191 |
| 68 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.19661506 |
| 69 | PHF8_20622853_ChIP-Seq_HELA_Human | 1.18654885 |
| 70 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.17699216 |
| 71 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.17345085 |
| 72 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.16255964 |
| 73 | CDX2_22108803_ChIP-Seq_LS180_Human | 1.15336920 |
| 74 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 1.14002035 |
| 75 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.13131864 |
| 76 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 1.10842536 |
| 77 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.10565225 |
| 78 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.10327739 |
| 79 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.10279921 |
| 80 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.10082467 |
| 81 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.10082467 |
| 82 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.08773025 |
| 83 | PCGF4_22325352_ChIP-Seq_293T-Rex_Human | 1.07105008 |
| 84 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 1.06579012 |
| 85 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.06169935 |
| 86 | HOXB7_26014856_ChIP-Seq_BT474_Human | 1.04946026 |
| 87 | CJUN_26792858_Chip-Seq_BT549_Human | 1.03937498 |
| 88 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.03827447 |
| 89 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.03430432 |
| 90 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.02334354 |
| 91 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.02066968 |
| 92 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.01877483 |
| 93 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.01599289 |
| 94 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 1.01085252 |
| 95 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.00507694 |
| 96 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.00143480 |
| 97 | ETV1_20927104_ChIP-Seq_GIST48_Human | 1.00122877 |
| 98 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.98131432 |
| 99 | TCF4_23295773_ChIP-Seq_U87_Human | 0.97899559 |
| 100 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.97837075 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003950_abnormal_plasma_membrane | 5.41103367 |
| 2 | MP0000372_irregular_coat_pigmentation | 3.90163110 |
| 3 | MP0003011_delayed_dark_adaptation | 3.86591859 |
| 4 | MP0005503_abnormal_tendon_morphology | 3.37656971 |
| 5 | MP0002102_abnormal_ear_morphology | 2.83980148 |
| 6 | MP0001348_abnormal_lacrimal_gland | 2.81105521 |
| 7 | MP0001835_abnormal_antigen_presentation | 2.72722449 |
| 8 | MP0009780_abnormal_chondrocyte_physiolo | 2.57231346 |
| 9 | MP0008877_abnormal_DNA_methylation | 2.55451892 |
| 10 | MP0003195_calcinosis | 2.46365436 |
| 11 | MP0002254_reproductive_system_inflammat | 2.36586835 |
| 12 | MP0006054_spinal_hemorrhage | 2.25822267 |
| 13 | MP0002876_abnormal_thyroid_physiology | 2.22965772 |
| 14 | MP0006072_abnormal_retinal_apoptosis | 1.96833987 |
| 15 | MP0003186_abnormal_redox_activity | 1.91989783 |
| 16 | MP0005253_abnormal_eye_physiology | 1.88110749 |
| 17 | MP0003283_abnormal_digestive_organ | 1.86833109 |
| 18 | MP0000685_abnormal_immune_system | 1.84362236 |
| 19 | MP0000569_abnormal_digit_pigmentation | 1.83753127 |
| 20 | MP0005171_absent_coat_pigmentation | 1.82945411 |
| 21 | MP0005671_abnormal_response_to | 1.80255251 |
| 22 | MP0009785_altered_susceptibility_to | 1.73490797 |
| 23 | MP0000427_abnormal_hair_cycle | 1.73483296 |
| 24 | MP0005408_hypopigmentation | 1.64886062 |
| 25 | MP0000516_abnormal_urinary_system | 1.60746760 |
| 26 | MP0005367_renal/urinary_system_phenotyp | 1.60746760 |
| 27 | MP0002166_altered_tumor_susceptibility | 1.59684965 |
| 28 | MP0001542_abnormal_bone_strength | 1.55488745 |
| 29 | MP0002282_abnormal_trachea_morphology | 1.54810478 |
| 30 | MP0004272_abnormal_basement_membrane | 1.54284462 |
| 31 | MP0003252_abnormal_bile_duct | 1.48301074 |
| 32 | MP0008438_abnormal_cutaneous_collagen | 1.47021775 |
| 33 | MP0002148_abnormal_hypersensitivity_rea | 1.39121244 |
| 34 | MP0002160_abnormal_reproductive_system | 1.37472582 |
| 35 | MP0000383_abnormal_hair_follicle | 1.36100799 |
| 36 | MP0005174_abnormal_tail_pigmentation | 1.35963633 |
| 37 | MP0003806_abnormal_nucleotide_metabolis | 1.33751031 |
| 38 | MP0002090_abnormal_vision | 1.31624848 |
| 39 | MP0008872_abnormal_physiological_respon | 1.27260039 |
| 40 | MP0009250_abnormal_appendicular_skeleto | 1.24629337 |
| 41 | MP0000613_abnormal_salivary_gland | 1.20566451 |
| 42 | MP0008875_abnormal_xenobiotic_pharmacok | 1.19591451 |
| 43 | MP0005084_abnormal_gallbladder_morpholo | 1.19359050 |
| 44 | MP0003279_aneurysm | 1.17805104 |
| 45 | MP0005275_abnormal_skin_tensile | 1.17124597 |
| 46 | MP0003763_abnormal_thymus_physiology | 1.16963623 |
| 47 | MP0002938_white_spotting | 1.16105067 |
| 48 | MP0009697_abnormal_copulation | 1.15655560 |
| 49 | MP0003137_abnormal_impulse_conducting | 1.15572477 |
| 50 | MP0005410_abnormal_fertilization | 1.14757797 |
| 51 | MP0005551_abnormal_eye_electrophysiolog | 1.14589145 |
| 52 | MP0004381_abnormal_hair_follicle | 1.12257009 |
| 53 | MP0008058_abnormal_DNA_repair | 1.08412279 |
| 54 | MP0004084_abnormal_cardiac_muscle | 1.05131886 |
| 55 | MP0003786_premature_aging | 1.04334223 |
| 56 | MP0002234_abnormal_pharynx_morphology | 1.02389897 |
| 57 | MP0000538_abnormal_urinary_bladder | 0.99037015 |
| 58 | MP0004145_abnormal_muscle_electrophysio | 0.98816762 |
| 59 | MP0002006_tumorigenesis | 0.97076931 |
| 60 | MP0009053_abnormal_anal_canal | 0.96905035 |
| 61 | MP0002168_other_aberrant_phenotype | 0.96655415 |
| 62 | MP0005332_abnormal_amino_acid | 0.95684614 |
| 63 | MP0005508_abnormal_skeleton_morphology | 0.95611512 |
| 64 | MP0001501_abnormal_sleep_pattern | 0.94296568 |
| 65 | MP0005075_abnormal_melanosome_morpholog | 0.93849399 |
| 66 | MP0001790_abnormal_immune_system | 0.93617588 |
| 67 | MP0005387_immune_system_phenotype | 0.93617588 |
| 68 | MP0002928_abnormal_bile_duct | 0.88248097 |
| 69 | MP0008775_abnormal_heart_ventricle | 0.87802495 |
| 70 | MP0000749_muscle_degeneration | 0.85925387 |
| 71 | MP0001119_abnormal_female_reproductive | 0.85662973 |
| 72 | MP0005000_abnormal_immune_tolerance | 0.85652303 |
| 73 | MP0002132_abnormal_respiratory_system | 0.84469167 |
| 74 | MP0002295_abnormal_pulmonary_circulatio | 0.84090218 |
| 75 | MP0005389_reproductive_system_phenotype | 0.83951883 |
| 76 | MP0005360_urolithiasis | 0.83055062 |
| 77 | MP0002736_abnormal_nociception_after | 0.81939030 |
| 78 | MP0003045_fibrosis | 0.80392650 |
| 79 | MP0004133_heterotaxia | 0.79046260 |
| 80 | MP0002452_abnormal_antigen_presenting | 0.77289314 |
| 81 | MP0000015_abnormal_ear_pigmentation | 0.73883788 |
| 82 | MP0010678_abnormal_skin_adnexa | 0.73030124 |
| 83 | MP0004484_altered_response_of | 0.72952095 |
| 84 | MP0006082_CNS_inflammation | 0.72717626 |
| 85 | MP0002420_abnormal_adaptive_immunity | 0.72570948 |
| 86 | MP0003937_abnormal_limbs/digits/tail_de | 0.72272382 |
| 87 | MP0001764_abnormal_homeostasis | 0.72025522 |
| 88 | MP0001819_abnormal_immune_cell | 0.71822939 |
| 89 | MP0006292_abnormal_olfactory_placode | 0.70822690 |
| 90 | MP0008007_abnormal_cellular_replicative | 0.70759567 |
| 91 | MP0002837_dystrophic_cardiac_calcinosis | 0.69918474 |
| 92 | MP0002163_abnormal_gland_morphology | 0.68759841 |
| 93 | MP0000371_diluted_coat_color | 0.68699057 |
| 94 | MP0001800_abnormal_humoral_immune | 0.68093639 |
| 95 | MP0002723_abnormal_immune_serum | 0.66735736 |
| 96 | MP0005379_endocrine/exocrine_gland_phen | 0.66338771 |
| 97 | MP0005395_other_phenotype | 0.65271423 |
| 98 | MP0005647_abnormal_sex_gland | 0.63935588 |
| 99 | MP0005390_skeleton_phenotype | 0.63431563 |
| 100 | MP0001485_abnormal_pinna_reflex | 0.63252095 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Aplasia of the musculature (HP:0100854) | 4.49425342 |
| 2 | Type II lissencephaly (HP:0007260) | 3.96806833 |
| 3 | Amniotic constriction ring (HP:0009775) | 3.87993479 |
| 4 | Abnormality of placental membranes (HP:0011409) | 3.87993479 |
| 5 | Calf muscle hypertrophy (HP:0008981) | 3.61775569 |
| 6 | Mesomelia (HP:0003027) | 3.50439070 |
| 7 | Pancreatic cysts (HP:0001737) | 3.40439728 |
| 8 | Metaphyseal dysplasia (HP:0100255) | 3.36794858 |
| 9 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 3.25830530 |
| 10 | Increased IgM level (HP:0003496) | 3.18079012 |
| 11 | Muscle hypertrophy of the lower extremities (HP:0008968) | 3.11876811 |
| 12 | Short middle phalanx of the 5th finger (HP:0004220) | 3.07109510 |
| 13 | Molar tooth sign on MRI (HP:0002419) | 3.02625106 |
| 14 | Abnormality of midbrain morphology (HP:0002418) | 3.02625106 |
| 15 | Congenital stationary night blindness (HP:0007642) | 2.99055146 |
| 16 | Bifid tongue (HP:0010297) | 2.90981119 |
| 17 | Acute necrotizing encephalopathy (HP:0006965) | 2.90163196 |
| 18 | Autoimmune hemolytic anemia (HP:0001890) | 2.83732186 |
| 19 | Parakeratosis (HP:0001036) | 2.81000269 |
| 20 | Renal cortical cysts (HP:0000803) | 2.78277379 |
| 21 | Dyschromatopsia (HP:0007641) | 2.77814860 |
| 22 | Hypoproteinemia (HP:0003075) | 2.77502905 |
| 23 | Progressive macrocephaly (HP:0004481) | 2.74078266 |
| 24 | Type 2 muscle fiber atrophy (HP:0003554) | 2.72856224 |
| 25 | 3-Methylglutaconic aciduria (HP:0003535) | 2.72768052 |
| 26 | Abnormality of T cell physiology (HP:0011840) | 2.71181216 |
| 27 | IgG deficiency (HP:0004315) | 2.68592620 |
| 28 | Acute encephalopathy (HP:0006846) | 2.64732871 |
| 29 | Tetraparesis (HP:0002273) | 2.57086508 |
| 30 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 2.53074378 |
| 31 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 2.49402338 |
| 32 | Abnormality of the renal cortex (HP:0011035) | 2.47357791 |
| 33 | Disproportionate short-trunk short stature (HP:0003521) | 2.41715688 |
| 34 | Increased CSF lactate (HP:0002490) | 2.40777207 |
| 35 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 2.40773283 |
| 36 | Mitochondrial inheritance (HP:0001427) | 2.39394766 |
| 37 | Posterior subcapsular cataract (HP:0007787) | 2.35434302 |
| 38 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 2.34933758 |
| 39 | Abnormality of the phalanges of the 5th finger (HP:0004213) | 2.33448424 |
| 40 | Pancreatic fibrosis (HP:0100732) | 2.33151246 |
| 41 | True hermaphroditism (HP:0010459) | 2.28760008 |
| 42 | Popliteal pterygium (HP:0009756) | 2.28558549 |
| 43 | Muscle fiber atrophy (HP:0100295) | 2.27419477 |
| 44 | Retinal dysplasia (HP:0007973) | 2.26320554 |
| 45 | Absent thumb (HP:0009777) | 2.24340160 |
| 46 | Autoimmune thrombocytopenia (HP:0001973) | 2.20304034 |
| 47 | Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376) | 2.18901428 |
| 48 | Stillbirth (HP:0003826) | 2.18292481 |
| 49 | Adrenal hypoplasia (HP:0000835) | 2.18174373 |
| 50 | Short tibia (HP:0005736) | 2.17537354 |
| 51 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.16524608 |
| 52 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.15624088 |
| 53 | Methylmalonic aciduria (HP:0012120) | 2.14631228 |
| 54 | Methylmalonic acidemia (HP:0002912) | 2.11583866 |
| 55 | Increased hepatocellular lipid droplets (HP:0006565) | 2.04568090 |
| 56 | Prostate neoplasm (HP:0100787) | 2.04326102 |
| 57 | Thyroiditis (HP:0100646) | 2.01870825 |
| 58 | Stomatitis (HP:0010280) | 2.01227086 |
| 59 | Small hand (HP:0200055) | 1.94630670 |
| 60 | Hypoplastic ischia (HP:0003175) | 1.93429246 |
| 61 | Lipid accumulation in hepatocytes (HP:0006561) | 1.92221594 |
| 62 | Cutaneous melanoma (HP:0012056) | 1.91883158 |
| 63 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.90602332 |
| 64 | Hypoplasia of the fovea (HP:0007750) | 1.89912688 |
| 65 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.89912688 |
| 66 | Testicular atrophy (HP:0000029) | 1.89376649 |
| 67 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 1.88845426 |
| 68 | Hepatocellular necrosis (HP:0001404) | 1.88760011 |
| 69 | Hypoplastic heart (HP:0001961) | 1.87690706 |
| 70 | Abnormality of the prostate (HP:0008775) | 1.87181352 |
| 71 | Supernumerary spleens (HP:0009799) | 1.86954986 |
| 72 | Cystic liver disease (HP:0006706) | 1.85168722 |
| 73 | Anencephaly (HP:0002323) | 1.82807216 |
| 74 | Median cleft lip (HP:0000161) | 1.82694559 |
| 75 | Entropion (HP:0000621) | 1.81267682 |
| 76 | Renal Fanconi syndrome (HP:0001994) | 1.80580990 |
| 77 | Asplenia (HP:0001746) | 1.80026338 |
| 78 | Cerebral edema (HP:0002181) | 1.79084077 |
| 79 | Albinism (HP:0001022) | 1.78190158 |
| 80 | Neuroendocrine neoplasm (HP:0100634) | 1.77567646 |
| 81 | Medial flaring of the eyebrow (HP:0010747) | 1.76655876 |
| 82 | Conjunctival hamartoma (HP:0100780) | 1.74898440 |
| 83 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.74642894 |
| 84 | Recurrent cutaneous fungal infections (HP:0011370) | 1.74642894 |
| 85 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 1.74570480 |
| 86 | Vasculitis (HP:0002633) | 1.74463198 |
| 87 | Increased serum lactate (HP:0002151) | 1.71589508 |
| 88 | Sclerocornea (HP:0000647) | 1.70546323 |
| 89 | Tongue fasciculations (HP:0001308) | 1.70291117 |
| 90 | Increased number of teeth (HP:0011069) | 1.69146217 |
| 91 | Vacuolated lymphocytes (HP:0001922) | 1.68390332 |
| 92 | Abnormality of the phalanges of the 2nd finger (HP:0009541) | 1.68291057 |
| 93 | Aplastic anemia (HP:0001915) | 1.67483931 |
| 94 | Congenital, generalized hypertrichosis (HP:0004540) | 1.66755298 |
| 95 | Increased cerebral lipofuscin (HP:0011813) | 1.66579756 |
| 96 | Optic disc pallor (HP:0000543) | 1.66459409 |
| 97 | Abnormal drinking behavior (HP:0030082) | 1.66126826 |
| 98 | Polydipsia (HP:0001959) | 1.66126826 |
| 99 | Hepatic necrosis (HP:0002605) | 1.65963717 |
| 100 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.64760505 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TRIM28 | 4.31394344 |
| 2 | MAP3K12 | 3.97113296 |
| 3 | FRK | 3.96652139 |
| 4 | CDK19 | 3.40341118 |
| 5 | SIK3 | 3.35418120 |
| 6 | EIF2AK3 | 3.28581953 |
| 7 | NUAK1 | 3.15133480 |
| 8 | BMPR2 | 2.49175763 |
| 9 | ERBB3 | 2.41960647 |
| 10 | MYLK | 2.24736241 |
| 11 | TLK1 | 2.24170595 |
| 12 | BCR | 2.24146803 |
| 13 | ACVR1B | 2.22361783 |
| 14 | TXK | 2.04391167 |
| 15 | ZAK | 1.99679440 |
| 16 | MUSK | 1.99601043 |
| 17 | EIF2AK1 | 1.93828662 |
| 18 | PAK3 | 1.81696285 |
| 19 | BMPR1B | 1.70660929 |
| 20 | MAP4K2 | 1.51587604 |
| 21 | PLK2 | 1.50096129 |
| 22 | FER | 1.45589917 |
| 23 | LIMK1 | 1.44201110 |
| 24 | MKNK2 | 1.39751956 |
| 25 | ADRBK2 | 1.37234324 |
| 26 | TRPM7 | 1.36141833 |
| 27 | BUB1 | 1.31483783 |
| 28 | GRK1 | 1.30256218 |
| 29 | NEK1 | 1.28847565 |
| 30 | MKNK1 | 1.23406371 |
| 31 | ILK | 1.17553843 |
| 32 | PLK3 | 1.17378243 |
| 33 | ROCK1 | 1.15761839 |
| 34 | BCKDK | 1.04833321 |
| 35 | TEC | 1.04194862 |
| 36 | STK3 | 0.95526245 |
| 37 | WNK4 | 0.95359005 |
| 38 | FLT3 | 0.94294012 |
| 39 | CAMK2D | 0.93928576 |
| 40 | WNK3 | 0.87891105 |
| 41 | FGFR1 | 0.81477941 |
| 42 | MAP4K1 | 0.81137322 |
| 43 | PRKCI | 0.78225633 |
| 44 | PRKCE | 0.76828613 |
| 45 | MAPKAPK3 | 0.76699804 |
| 46 | DDR2 | 0.75984866 |
| 47 | TYK2 | 0.74174317 |
| 48 | MAPKAPK5 | 0.73013702 |
| 49 | MAPK13 | 0.71690815 |
| 50 | IKBKB | 0.67839285 |
| 51 | NME1 | 0.67596300 |
| 52 | INSRR | 0.67382901 |
| 53 | OXSR1 | 0.66661710 |
| 54 | PINK1 | 0.64961534 |
| 55 | WEE1 | 0.64891608 |
| 56 | ADRBK1 | 0.64270275 |
| 57 | TGFBR1 | 0.63186766 |
| 58 | MARK3 | 0.57434281 |
| 59 | IGF1R | 0.55587577 |
| 60 | LATS1 | 0.55248119 |
| 61 | PASK | 0.54378920 |
| 62 | EIF2AK2 | 0.53831808 |
| 63 | PTK2B | 0.53736864 |
| 64 | ABL1 | 0.53728265 |
| 65 | FGFR2 | 0.53339992 |
| 66 | PBK | 0.51753883 |
| 67 | MAP2K1 | 0.48775931 |
| 68 | PNCK | 0.47593462 |
| 69 | CAMK2A | 0.47227311 |
| 70 | VRK1 | 0.47044672 |
| 71 | PAK6 | 0.46973613 |
| 72 | HCK | 0.45800879 |
| 73 | MINK1 | 0.45522334 |
| 74 | MST4 | 0.44967056 |
| 75 | STK39 | 0.42860581 |
| 76 | CAMK2G | 0.40934455 |
| 77 | ITK | 0.40281363 |
| 78 | MAP3K3 | 0.40235956 |
| 79 | GSK3A | 0.39893315 |
| 80 | PRKCQ | 0.34593199 |
| 81 | NEK9 | 0.34513471 |
| 82 | CSNK2A1 | 0.33933012 |
| 83 | PRKCD | 0.32455291 |
| 84 | PRKACA | 0.32188269 |
| 85 | KSR1 | 0.31771731 |
| 86 | DAPK1 | 0.31382256 |
| 87 | PRKCA | 0.31074333 |
| 88 | TNK2 | 0.30979631 |
| 89 | PRKD3 | 0.30241761 |
| 90 | DAPK3 | 0.29845787 |
| 91 | KDR | 0.28981753 |
| 92 | PAK1 | 0.28208684 |
| 93 | BRSK2 | 0.27350095 |
| 94 | TIE1 | 0.26999951 |
| 95 | PRKG1 | 0.25807470 |
| 96 | PRKCG | 0.25707082 |
| 97 | PRKCB | 0.25509895 |
| 98 | RAF1 | 0.24472469 |
| 99 | SYK | 0.24166109 |
| 100 | ROCK2 | 0.23984105 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.37978102 |
| 2 | Protein export_Homo sapiens_hsa03060 | 4.34995537 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.48708063 |
| 4 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.33031773 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.23479577 |
| 6 | Asthma_Homo sapiens_hsa05310 | 2.22782689 |
| 7 | Homologous recombination_Homo sapiens_hsa03440 | 2.16133248 |
| 8 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.09845856 |
| 9 | Primary immunodeficiency_Homo sapiens_hsa05340 | 2.02009570 |
| 10 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.98375142 |
| 11 | Parkinsons disease_Homo sapiens_hsa05012 | 1.89494465 |
| 12 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.80388632 |
| 13 | Allograft rejection_Homo sapiens_hsa05330 | 1.75360954 |
| 14 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.67149968 |
| 15 | Basal transcription factors_Homo sapiens_hsa03022 | 1.66555064 |
| 16 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.63820849 |
| 17 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.63315736 |
| 18 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.60349416 |
| 19 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.56778935 |
| 20 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.53261135 |
| 21 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.50638515 |
| 22 | RNA degradation_Homo sapiens_hsa03018 | 1.48541332 |
| 23 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.42012921 |
| 24 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.40146100 |
| 25 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.38463910 |
| 26 | Phototransduction_Homo sapiens_hsa04744 | 1.36981710 |
| 27 | Ribosome_Homo sapiens_hsa03010 | 1.32331069 |
| 28 | RNA transport_Homo sapiens_hsa03013 | 1.31249515 |
| 29 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.29345829 |
| 30 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.29285918 |
| 31 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.27992202 |
| 32 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.27460400 |
| 33 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.25584626 |
| 34 | Alzheimers disease_Homo sapiens_hsa05010 | 1.22545677 |
| 35 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.20973200 |
| 36 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.19852744 |
| 37 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.17019897 |
| 38 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.14269501 |
| 39 | Huntingtons disease_Homo sapiens_hsa05016 | 1.12548266 |
| 40 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.05937539 |
| 41 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.03613177 |
| 42 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.02878189 |
| 43 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.02785748 |
| 44 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.01658138 |
| 45 | Mismatch repair_Homo sapiens_hsa03430 | 1.01636063 |
| 46 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.99957368 |
| 47 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.99822260 |
| 48 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.95235914 |
| 49 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.94342856 |
| 50 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.94309338 |
| 51 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.93831959 |
| 52 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.93114941 |
| 53 | Mineral absorption_Homo sapiens_hsa04978 | 0.89232953 |
| 54 | Olfactory transduction_Homo sapiens_hsa04740 | 0.89068939 |
| 55 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.88728858 |
| 56 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.88316275 |
| 57 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.85103858 |
| 58 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.84628374 |
| 59 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.84328401 |
| 60 | Legionellosis_Homo sapiens_hsa05134 | 0.83956692 |
| 61 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.82113910 |
| 62 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.80073724 |
| 63 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.79648777 |
| 64 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.78294598 |
| 65 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.78000140 |
| 66 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.77674853 |
| 67 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.77597100 |
| 68 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.77592594 |
| 69 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.74193712 |
| 70 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.72842350 |
| 71 | Purine metabolism_Homo sapiens_hsa00230 | 0.68494723 |
| 72 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.68475146 |
| 73 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.68249457 |
| 74 | Metabolic pathways_Homo sapiens_hsa01100 | 0.68047910 |
| 75 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.65155624 |
| 76 | Retinol metabolism_Homo sapiens_hsa00830 | 0.64472268 |
| 77 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.64450670 |
| 78 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.64414912 |
| 79 | Spliceosome_Homo sapiens_hsa03040 | 0.59976252 |
| 80 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.59793009 |
| 81 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.56507279 |
| 82 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.51152324 |
| 83 | Viral myocarditis_Homo sapiens_hsa05416 | 0.50042741 |
| 84 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.49087612 |
| 85 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.48696181 |
| 86 | Malaria_Homo sapiens_hsa05144 | 0.48589473 |
| 87 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.48204185 |
| 88 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.46770571 |
| 89 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.46212825 |
| 90 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.43031379 |
| 91 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.42280034 |
| 92 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.40798630 |
| 93 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.38968382 |
| 94 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.38084405 |
| 95 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.37220103 |
| 96 | Peroxisome_Homo sapiens_hsa04146 | 0.35525660 |
| 97 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.33852860 |
| 98 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.31658601 |
| 99 | ABC transporters_Homo sapiens_hsa02010 | 0.30739485 |
| 100 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.29940030 |

