MAGOH3P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)6.71893240
2positive regulation of natural killer cell differentiation (GO:0032825)6.47275756
3regulation of protein glycosylation (GO:0060049)5.38480217
4DNA deamination (GO:0045006)4.79961967
5cellular response to interferon-alpha (GO:0035457)4.51390907
6fucose catabolic process (GO:0019317)4.50699461
7L-fucose metabolic process (GO:0042354)4.50699461
8L-fucose catabolic process (GO:0042355)4.50699461
9regulation of natural killer cell differentiation (GO:0032823)4.48412546
10signal peptide processing (GO:0006465)4.36901136
11platelet dense granule organization (GO:0060155)4.28324704
12establishment of protein localization to mitochondrial membrane (GO:0090151)3.99483354
13regulation of interleukin-8 secretion (GO:2000482)3.66029444
14pericardium development (GO:0060039)3.61750273
15arginine catabolic process (GO:0006527)3.56735414
16vagina development (GO:0060068)3.45320020
17protein-cofactor linkage (GO:0018065)3.41317107
18positive regulation of interleukin-8 secretion (GO:2000484)3.39566288
19mesenchymal-epithelial cell signaling (GO:0060638)3.38256062
20response to interferon-alpha (GO:0035455)3.30855603
21regulation of cellular amino acid metabolic process (GO:0006521)3.25381675
22anterograde synaptic vesicle transport (GO:0048490)3.25197874
23negative regulation of mast cell activation (GO:0033004)3.24001588
24rRNA modification (GO:0000154)3.22159658
25DNA double-strand break processing (GO:0000729)3.21810091
26negative regulation of axon extension involved in axon guidance (GO:0048843)3.21700081
27ATP synthesis coupled proton transport (GO:0015986)3.08073427
28energy coupled proton transport, down electrochemical gradient (GO:0015985)3.08073427
29ovulation cycle (GO:0042698)3.04189045
30preassembly of GPI anchor in ER membrane (GO:0016254)3.03938014
31negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.02251687
32protein neddylation (GO:0045116)3.01984875
33regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.01284047
34positive regulation of vesicle fusion (GO:0031340)2.96774205
35dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.94708550
36transcription elongation from RNA polymerase III promoter (GO:0006385)2.94121197
37termination of RNA polymerase III transcription (GO:0006386)2.94121197
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.90374844
39somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.87939656
40somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.87939656
41isotype switching (GO:0045190)2.87939656
42rRNA methylation (GO:0031167)2.86801134
43DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.83987738
44pseudouridine synthesis (GO:0001522)2.81757936
45negative regulation of axon guidance (GO:1902668)2.81579309
46respiratory chain complex IV assembly (GO:0008535)2.80761550
47endocrine hormone secretion (GO:0060986)2.80702100
48signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.76445400
49signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.76445400
50signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.76445400
51positive regulation of natural killer cell activation (GO:0032816)2.75949590
52negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.75547635
53water-soluble vitamin biosynthetic process (GO:0042364)2.73764151
54signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.73181639
55intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.73181639
56xenobiotic catabolic process (GO:0042178)2.72153649
57regulation of metalloenzyme activity (GO:0048552)2.68015323
58lens development in camera-type eye (GO:0002088)2.67618134
59glycerophospholipid catabolic process (GO:0046475)2.67023413
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.66382922
61female genitalia development (GO:0030540)2.65950691
62nucleotide-sugar biosynthetic process (GO:0009226)2.65742415
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.65454920
64branched-chain amino acid catabolic process (GO:0009083)2.64654622
65membrane raft organization (GO:0031579)2.63840952
66UMP metabolic process (GO:0046049)2.63382834
67pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.63382834
68UMP biosynthetic process (GO:0006222)2.63382834
69pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.63382834
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.62914375
71positive regulation of protein autophosphorylation (GO:0031954)2.62888017
72sulfation (GO:0051923)2.62011199
73regulation of nuclear cell cycle DNA replication (GO:0033262)2.59823471
74double-strand break repair via homologous recombination (GO:0000724)2.59523151
75N-acetylglucosamine metabolic process (GO:0006044)2.58879509
76signal transduction involved in DNA integrity checkpoint (GO:0072401)2.58684505
77signal transduction involved in DNA damage checkpoint (GO:0072422)2.58684505
78aldehyde catabolic process (GO:0046185)2.57820894
79signal transduction involved in cell cycle checkpoint (GO:0072395)2.53771269
80recombinational repair (GO:0000725)2.52874851
81cytochrome complex assembly (GO:0017004)2.49537387
82exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.49007918
83mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.48903501
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.48488421
85regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.45798597
867-methylguanosine mRNA capping (GO:0006370)2.45471209
87negative regulation of signal transduction by p53 class mediator (GO:1901797)2.45403022
88protein K11-linked deubiquitination (GO:0035871)2.44738725
89cell wall macromolecule metabolic process (GO:0044036)2.43271855
90positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.43107190
91negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.42996929
92regulation of mitotic spindle checkpoint (GO:1903504)2.42082858
93regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.42082858
94RNA capping (GO:0036260)2.40443325
957-methylguanosine RNA capping (GO:0009452)2.40443325
96positive regulation of steroid hormone secretion (GO:2000833)2.40434730
97UDP-N-acetylglucosamine metabolic process (GO:0006047)2.39283079
98inner mitochondrial membrane organization (GO:0007007)2.38350956
99tRNA processing (GO:0008033)2.38228603
100negative regulation of ligase activity (GO:0051352)2.37049314

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.68766367
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.43349571
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.31647170
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.14570154
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.07166988
6VDR_22108803_ChIP-Seq_LS180_Human2.97678540
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.87406526
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.80407608
9ELK1_19687146_ChIP-ChIP_HELA_Human2.79548857
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.44382171
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.40890753
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35236615
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.32883614
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26872579
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.16575563
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08246050
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.02629032
18ER_23166858_ChIP-Seq_MCF-7_Human1.98531263
19VDR_23849224_ChIP-Seq_CD4+_Human1.95920584
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94415085
21EWS_26573619_Chip-Seq_HEK293_Human1.85603809
22ZNF274_21170338_ChIP-Seq_K562_Hela1.81827210
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79689346
24P300_19829295_ChIP-Seq_ESCs_Human1.74311554
25BCAT_22108803_ChIP-Seq_LS180_Human1.73667155
26GBX2_23144817_ChIP-Seq_PC3_Human1.71543785
27IGF1R_20145208_ChIP-Seq_DFB_Human1.70765461
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62032169
29EZH2_27294783_Chip-Seq_NPCs_Mouse1.61475885
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61412733
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61231159
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60069721
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.55310171
34MYC_18940864_ChIP-ChIP_HL60_Human1.54795933
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.54726823
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53678713
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53470599
38AUTS2_25519132_ChIP-Seq_293T-REX_Human1.52016079
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50510261
40TCF4_22108803_ChIP-Seq_LS180_Human1.46472633
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.46049634
42CBP_20019798_ChIP-Seq_JUKART_Human1.43203328
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43203328
44CRX_20693478_ChIP-Seq_RETINA_Mouse1.40836738
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.40436916
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.40042898
47TP53_22573176_ChIP-Seq_HFKS_Human1.39240707
48CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.38916994
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35996635
50AR_20517297_ChIP-Seq_VCAP_Human1.35177064
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32780102
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.32709133
53FOXP3_21729870_ChIP-Seq_TREG_Human1.31103535
54FUS_26573619_Chip-Seq_HEK293_Human1.31055450
55BRD4_25478319_ChIP-Seq_HGPS_Human1.29736519
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.26242317
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26242317
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26194754
59NANOG_19829295_ChIP-Seq_ESCs_Human1.25206930
60SOX2_19829295_ChIP-Seq_ESCs_Human1.25206930
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23397951
62RBPJ_21746931_ChIP-Seq_IB4_Human1.22658073
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22516875
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21579010
65CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21190190
66GATA3_26560356_Chip-Seq_TH2_Human1.21106919
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20463191
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19661506
69PHF8_20622853_ChIP-Seq_HELA_Human1.18654885
70ELK1_22589737_ChIP-Seq_MCF10A_Human1.17699216
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17345085
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16255964
73CDX2_22108803_ChIP-Seq_LS180_Human1.15336920
74SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14002035
75RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13131864
76GATA6_21074721_ChIP-Seq_CACO-2_Human1.10842536
77SMAD4_21799915_ChIP-Seq_A2780_Human1.10565225
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10327739
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10279921
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10082467
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10082467
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.08773025
83PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.07105008
84OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06579012
85IRF1_19129219_ChIP-ChIP_H3396_Human1.06169935
86HOXB7_26014856_ChIP-Seq_BT474_Human1.04946026
87CJUN_26792858_Chip-Seq_BT549_Human1.03937498
88PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.03827447
89NOTCH1_21737748_ChIP-Seq_TLL_Human1.03430432
90CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02334354
91DCP1A_22483619_ChIP-Seq_HELA_Human1.02066968
92TP53_18474530_ChIP-ChIP_U2OS_Human1.01877483
93P53_22387025_ChIP-Seq_ESCs_Mouse1.01599289
94GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01085252
95PIAS1_25552417_ChIP-Seq_VCAP_Human1.00507694
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.00143480
97ETV1_20927104_ChIP-Seq_GIST48_Human1.00122877
98TAF15_26573619_Chip-Seq_HEK293_Human0.98131432
99TCF4_23295773_ChIP-Seq_U87_Human0.97899559
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97837075

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane5.41103367
2MP0000372_irregular_coat_pigmentation3.90163110
3MP0003011_delayed_dark_adaptation3.86591859
4MP0005503_abnormal_tendon_morphology3.37656971
5MP0002102_abnormal_ear_morphology2.83980148
6MP0001348_abnormal_lacrimal_gland2.81105521
7MP0001835_abnormal_antigen_presentation2.72722449
8MP0009780_abnormal_chondrocyte_physiolo2.57231346
9MP0008877_abnormal_DNA_methylation2.55451892
10MP0003195_calcinosis2.46365436
11MP0002254_reproductive_system_inflammat2.36586835
12MP0006054_spinal_hemorrhage2.25822267
13MP0002876_abnormal_thyroid_physiology2.22965772
14MP0006072_abnormal_retinal_apoptosis1.96833987
15MP0003186_abnormal_redox_activity1.91989783
16MP0005253_abnormal_eye_physiology1.88110749
17MP0003283_abnormal_digestive_organ1.86833109
18MP0000685_abnormal_immune_system1.84362236
19MP0000569_abnormal_digit_pigmentation1.83753127
20MP0005171_absent_coat_pigmentation1.82945411
21MP0005671_abnormal_response_to1.80255251
22MP0009785_altered_susceptibility_to1.73490797
23MP0000427_abnormal_hair_cycle1.73483296
24MP0005408_hypopigmentation1.64886062
25MP0000516_abnormal_urinary_system1.60746760
26MP0005367_renal/urinary_system_phenotyp1.60746760
27MP0002166_altered_tumor_susceptibility1.59684965
28MP0001542_abnormal_bone_strength1.55488745
29MP0002282_abnormal_trachea_morphology1.54810478
30MP0004272_abnormal_basement_membrane1.54284462
31MP0003252_abnormal_bile_duct1.48301074
32MP0008438_abnormal_cutaneous_collagen1.47021775
33MP0002148_abnormal_hypersensitivity_rea1.39121244
34MP0002160_abnormal_reproductive_system1.37472582
35MP0000383_abnormal_hair_follicle1.36100799
36MP0005174_abnormal_tail_pigmentation1.35963633
37MP0003806_abnormal_nucleotide_metabolis1.33751031
38MP0002090_abnormal_vision1.31624848
39MP0008872_abnormal_physiological_respon1.27260039
40MP0009250_abnormal_appendicular_skeleto1.24629337
41MP0000613_abnormal_salivary_gland1.20566451
42MP0008875_abnormal_xenobiotic_pharmacok1.19591451
43MP0005084_abnormal_gallbladder_morpholo1.19359050
44MP0003279_aneurysm1.17805104
45MP0005275_abnormal_skin_tensile1.17124597
46MP0003763_abnormal_thymus_physiology1.16963623
47MP0002938_white_spotting1.16105067
48MP0009697_abnormal_copulation1.15655560
49MP0003137_abnormal_impulse_conducting1.15572477
50MP0005410_abnormal_fertilization1.14757797
51MP0005551_abnormal_eye_electrophysiolog1.14589145
52MP0004381_abnormal_hair_follicle1.12257009
53MP0008058_abnormal_DNA_repair1.08412279
54MP0004084_abnormal_cardiac_muscle1.05131886
55MP0003786_premature_aging1.04334223
56MP0002234_abnormal_pharynx_morphology1.02389897
57MP0000538_abnormal_urinary_bladder0.99037015
58MP0004145_abnormal_muscle_electrophysio0.98816762
59MP0002006_tumorigenesis0.97076931
60MP0009053_abnormal_anal_canal0.96905035
61MP0002168_other_aberrant_phenotype0.96655415
62MP0005332_abnormal_amino_acid0.95684614
63MP0005508_abnormal_skeleton_morphology0.95611512
64MP0001501_abnormal_sleep_pattern0.94296568
65MP0005075_abnormal_melanosome_morpholog0.93849399
66MP0001790_abnormal_immune_system0.93617588
67MP0005387_immune_system_phenotype0.93617588
68MP0002928_abnormal_bile_duct0.88248097
69MP0008775_abnormal_heart_ventricle0.87802495
70MP0000749_muscle_degeneration0.85925387
71MP0001119_abnormal_female_reproductive0.85662973
72MP0005000_abnormal_immune_tolerance0.85652303
73MP0002132_abnormal_respiratory_system0.84469167
74MP0002295_abnormal_pulmonary_circulatio0.84090218
75MP0005389_reproductive_system_phenotype0.83951883
76MP0005360_urolithiasis0.83055062
77MP0002736_abnormal_nociception_after0.81939030
78MP0003045_fibrosis0.80392650
79MP0004133_heterotaxia0.79046260
80MP0002452_abnormal_antigen_presenting0.77289314
81MP0000015_abnormal_ear_pigmentation0.73883788
82MP0010678_abnormal_skin_adnexa0.73030124
83MP0004484_altered_response_of0.72952095
84MP0006082_CNS_inflammation0.72717626
85MP0002420_abnormal_adaptive_immunity0.72570948
86MP0003937_abnormal_limbs/digits/tail_de0.72272382
87MP0001764_abnormal_homeostasis0.72025522
88MP0001819_abnormal_immune_cell0.71822939
89MP0006292_abnormal_olfactory_placode0.70822690
90MP0008007_abnormal_cellular_replicative0.70759567
91MP0002837_dystrophic_cardiac_calcinosis0.69918474
92MP0002163_abnormal_gland_morphology0.68759841
93MP0000371_diluted_coat_color0.68699057
94MP0001800_abnormal_humoral_immune0.68093639
95MP0002723_abnormal_immune_serum0.66735736
96MP0005379_endocrine/exocrine_gland_phen0.66338771
97MP0005395_other_phenotype0.65271423
98MP0005647_abnormal_sex_gland0.63935588
99MP0005390_skeleton_phenotype0.63431563
100MP0001485_abnormal_pinna_reflex0.63252095

Predicted human phenotypes

RankGene SetZ-score
1Aplasia of the musculature (HP:0100854)4.49425342
2Type II lissencephaly (HP:0007260)3.96806833
3Amniotic constriction ring (HP:0009775)3.87993479
4Abnormality of placental membranes (HP:0011409)3.87993479
5Calf muscle hypertrophy (HP:0008981)3.61775569
6Mesomelia (HP:0003027)3.50439070
7Pancreatic cysts (HP:0001737)3.40439728
8Metaphyseal dysplasia (HP:0100255)3.36794858
9Aplasia/Hypoplasia involving the musculature (HP:0001460)3.25830530
10Increased IgM level (HP:0003496)3.18079012
11Muscle hypertrophy of the lower extremities (HP:0008968)3.11876811
12Short middle phalanx of the 5th finger (HP:0004220)3.07109510
13Molar tooth sign on MRI (HP:0002419)3.02625106
14Abnormality of midbrain morphology (HP:0002418)3.02625106
15Congenital stationary night blindness (HP:0007642)2.99055146
16Bifid tongue (HP:0010297)2.90981119
17Acute necrotizing encephalopathy (HP:0006965)2.90163196
18Autoimmune hemolytic anemia (HP:0001890)2.83732186
19Parakeratosis (HP:0001036)2.81000269
20Renal cortical cysts (HP:0000803)2.78277379
21Dyschromatopsia (HP:0007641)2.77814860
22Hypoproteinemia (HP:0003075)2.77502905
23Progressive macrocephaly (HP:0004481)2.74078266
24Type 2 muscle fiber atrophy (HP:0003554)2.72856224
253-Methylglutaconic aciduria (HP:0003535)2.72768052
26Abnormality of T cell physiology (HP:0011840)2.71181216
27IgG deficiency (HP:0004315)2.68592620
28Acute encephalopathy (HP:0006846)2.64732871
29Tetraparesis (HP:0002273)2.57086508
30Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.53074378
31Increased neuronal autofluorescent lipopigment (HP:0002074)2.49402338
32Abnormality of the renal cortex (HP:0011035)2.47357791
33Disproportionate short-trunk short stature (HP:0003521)2.41715688
34Increased CSF lactate (HP:0002490)2.40777207
35Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.40773283
36Mitochondrial inheritance (HP:0001427)2.39394766
37Posterior subcapsular cataract (HP:0007787)2.35434302
38Aplasia/Hypoplasia of the tongue (HP:0010295)2.34933758
39Abnormality of the phalanges of the 5th finger (HP:0004213)2.33448424
40Pancreatic fibrosis (HP:0100732)2.33151246
41True hermaphroditism (HP:0010459)2.28760008
42Popliteal pterygium (HP:0009756)2.28558549
43Muscle fiber atrophy (HP:0100295)2.27419477
44Retinal dysplasia (HP:0007973)2.26320554
45Absent thumb (HP:0009777)2.24340160
46Autoimmune thrombocytopenia (HP:0001973)2.20304034
47Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.18901428
48Stillbirth (HP:0003826)2.18292481
49Adrenal hypoplasia (HP:0000835)2.18174373
50Short tibia (HP:0005736)2.17537354
51Abnormal mitochondria in muscle tissue (HP:0008316)2.16524608
52Aplasia/Hypoplasia of the tibia (HP:0005772)2.15624088
53Methylmalonic aciduria (HP:0012120)2.14631228
54Methylmalonic acidemia (HP:0002912)2.11583866
55Increased hepatocellular lipid droplets (HP:0006565)2.04568090
56Prostate neoplasm (HP:0100787)2.04326102
57Thyroiditis (HP:0100646)2.01870825
58Stomatitis (HP:0010280)2.01227086
59Small hand (HP:0200055)1.94630670
60Hypoplastic ischia (HP:0003175)1.93429246
61Lipid accumulation in hepatocytes (HP:0006561)1.92221594
62Cutaneous melanoma (HP:0012056)1.91883158
63Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90602332
64Hypoplasia of the fovea (HP:0007750)1.89912688
65Aplasia/Hypoplasia of the fovea (HP:0008060)1.89912688
66Testicular atrophy (HP:0000029)1.89376649
67Aplasia/Hypoplasia of the spleen (HP:0010451)1.88845426
68Hepatocellular necrosis (HP:0001404)1.88760011
69Hypoplastic heart (HP:0001961)1.87690706
70Abnormality of the prostate (HP:0008775)1.87181352
71Supernumerary spleens (HP:0009799)1.86954986
72Cystic liver disease (HP:0006706)1.85168722
73Anencephaly (HP:0002323)1.82807216
74Median cleft lip (HP:0000161)1.82694559
75Entropion (HP:0000621)1.81267682
76Renal Fanconi syndrome (HP:0001994)1.80580990
77Asplenia (HP:0001746)1.80026338
78Cerebral edema (HP:0002181)1.79084077
79Albinism (HP:0001022)1.78190158
80Neuroendocrine neoplasm (HP:0100634)1.77567646
81Medial flaring of the eyebrow (HP:0010747)1.76655876
82Conjunctival hamartoma (HP:0100780)1.74898440
83Chronic mucocutaneous candidiasis (HP:0002728)1.74642894
84Recurrent cutaneous fungal infections (HP:0011370)1.74642894
85Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.74570480
86Vasculitis (HP:0002633)1.74463198
87Increased serum lactate (HP:0002151)1.71589508
88Sclerocornea (HP:0000647)1.70546323
89Tongue fasciculations (HP:0001308)1.70291117
90Increased number of teeth (HP:0011069)1.69146217
91Vacuolated lymphocytes (HP:0001922)1.68390332
92Abnormality of the phalanges of the 2nd finger (HP:0009541)1.68291057
93Aplastic anemia (HP:0001915)1.67483931
94Congenital, generalized hypertrichosis (HP:0004540)1.66755298
95Increased cerebral lipofuscin (HP:0011813)1.66579756
96Optic disc pallor (HP:0000543)1.66459409
97Abnormal drinking behavior (HP:0030082)1.66126826
98Polydipsia (HP:0001959)1.66126826
99Hepatic necrosis (HP:0002605)1.65963717
100Abnormal rod and cone electroretinograms (HP:0008323)1.64760505

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.31394344
2MAP3K123.97113296
3FRK3.96652139
4CDK193.40341118
5SIK33.35418120
6EIF2AK33.28581953
7NUAK13.15133480
8BMPR22.49175763
9ERBB32.41960647
10MYLK2.24736241
11TLK12.24170595
12BCR2.24146803
13ACVR1B2.22361783
14TXK2.04391167
15ZAK1.99679440
16MUSK1.99601043
17EIF2AK11.93828662
18PAK31.81696285
19BMPR1B1.70660929
20MAP4K21.51587604
21PLK21.50096129
22FER1.45589917
23LIMK11.44201110
24MKNK21.39751956
25ADRBK21.37234324
26TRPM71.36141833
27BUB11.31483783
28GRK11.30256218
29NEK11.28847565
30MKNK11.23406371
31ILK1.17553843
32PLK31.17378243
33ROCK11.15761839
34BCKDK1.04833321
35TEC1.04194862
36STK30.95526245
37WNK40.95359005
38FLT30.94294012
39CAMK2D0.93928576
40WNK30.87891105
41FGFR10.81477941
42MAP4K10.81137322
43PRKCI0.78225633
44PRKCE0.76828613
45MAPKAPK30.76699804
46DDR20.75984866
47TYK20.74174317
48MAPKAPK50.73013702
49MAPK130.71690815
50IKBKB0.67839285
51NME10.67596300
52INSRR0.67382901
53OXSR10.66661710
54PINK10.64961534
55WEE10.64891608
56ADRBK10.64270275
57TGFBR10.63186766
58MARK30.57434281
59IGF1R0.55587577
60LATS10.55248119
61PASK0.54378920
62EIF2AK20.53831808
63PTK2B0.53736864
64ABL10.53728265
65FGFR20.53339992
66PBK0.51753883
67MAP2K10.48775931
68PNCK0.47593462
69CAMK2A0.47227311
70VRK10.47044672
71PAK60.46973613
72HCK0.45800879
73MINK10.45522334
74MST40.44967056
75STK390.42860581
76CAMK2G0.40934455
77ITK0.40281363
78MAP3K30.40235956
79GSK3A0.39893315
80PRKCQ0.34593199
81NEK90.34513471
82CSNK2A10.33933012
83PRKCD0.32455291
84PRKACA0.32188269
85KSR10.31771731
86DAPK10.31382256
87PRKCA0.31074333
88TNK20.30979631
89PRKD30.30241761
90DAPK30.29845787
91KDR0.28981753
92PAK10.28208684
93BRSK20.27350095
94TIE10.26999951
95PRKG10.25807470
96PRKCG0.25707082
97PRKCB0.25509895
98RAF10.24472469
99SYK0.24166109
100ROCK20.23984105

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.37978102
2Protein export_Homo sapiens_hsa030604.34995537
3Oxidative phosphorylation_Homo sapiens_hsa001902.48708063
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.33031773
5RNA polymerase_Homo sapiens_hsa030202.23479577
6Asthma_Homo sapiens_hsa053102.22782689
7Homologous recombination_Homo sapiens_hsa034402.16133248
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.09845856
9Primary immunodeficiency_Homo sapiens_hsa053402.02009570
10Propanoate metabolism_Homo sapiens_hsa006401.98375142
11Parkinsons disease_Homo sapiens_hsa050121.89494465
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.80388632
13Allograft rejection_Homo sapiens_hsa053301.75360954
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.67149968
15Basal transcription factors_Homo sapiens_hsa030221.66555064
16Linoleic acid metabolism_Homo sapiens_hsa005911.63820849
17Fanconi anemia pathway_Homo sapiens_hsa034601.63315736
18Nitrogen metabolism_Homo sapiens_hsa009101.60349416
19Autoimmune thyroid disease_Homo sapiens_hsa053201.56778935
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53261135
21Sulfur metabolism_Homo sapiens_hsa009201.50638515
22RNA degradation_Homo sapiens_hsa030181.48541332
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42012921
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40146100
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38463910
26Phototransduction_Homo sapiens_hsa047441.36981710
27Ribosome_Homo sapiens_hsa030101.32331069
28RNA transport_Homo sapiens_hsa030131.31249515
29Pyrimidine metabolism_Homo sapiens_hsa002401.29345829
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29285918
31Vitamin B6 metabolism_Homo sapiens_hsa007501.27992202
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27460400
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25584626
34Alzheimers disease_Homo sapiens_hsa050101.22545677
35Hematopoietic cell lineage_Homo sapiens_hsa046401.20973200
36Graft-versus-host disease_Homo sapiens_hsa053321.19852744
37One carbon pool by folate_Homo sapiens_hsa006701.17019897
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14269501
39Huntingtons disease_Homo sapiens_hsa050161.12548266
40Nucleotide excision repair_Homo sapiens_hsa034201.05937539
41Arachidonic acid metabolism_Homo sapiens_hsa005901.03613177
42Steroid biosynthesis_Homo sapiens_hsa001001.02878189
43Ether lipid metabolism_Homo sapiens_hsa005651.02785748
44Chemical carcinogenesis_Homo sapiens_hsa052041.01658138
45Mismatch repair_Homo sapiens_hsa034301.01636063
46Caffeine metabolism_Homo sapiens_hsa002320.99957368
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99822260
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95235914
49Type I diabetes mellitus_Homo sapiens_hsa049400.94342856
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94309338
51Selenocompound metabolism_Homo sapiens_hsa004500.93831959
52Non-homologous end-joining_Homo sapiens_hsa034500.93114941
53Mineral absorption_Homo sapiens_hsa049780.89232953
54Olfactory transduction_Homo sapiens_hsa047400.89068939
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.88728858
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88316275
57Cardiac muscle contraction_Homo sapiens_hsa042600.85103858
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84628374
59Rheumatoid arthritis_Homo sapiens_hsa053230.84328401
60Legionellosis_Homo sapiens_hsa051340.83956692
61Folate biosynthesis_Homo sapiens_hsa007900.82113910
62Pentose phosphate pathway_Homo sapiens_hsa000300.80073724
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79648777
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78294598
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78000140
66Butanoate metabolism_Homo sapiens_hsa006500.77674853
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77597100
68Glutathione metabolism_Homo sapiens_hsa004800.77592594
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74193712
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72842350
71Purine metabolism_Homo sapiens_hsa002300.68494723
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68475146
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68249457
74Metabolic pathways_Homo sapiens_hsa011000.68047910
75Antigen processing and presentation_Homo sapiens_hsa046120.65155624
76Retinol metabolism_Homo sapiens_hsa008300.64472268
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.64450670
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64414912
79Spliceosome_Homo sapiens_hsa030400.59976252
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59793009
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56507279
82beta-Alanine metabolism_Homo sapiens_hsa004100.51152324
83Viral myocarditis_Homo sapiens_hsa054160.50042741
84Tryptophan metabolism_Homo sapiens_hsa003800.49087612
85Hedgehog signaling pathway_Homo sapiens_hsa043400.48696181
86Malaria_Homo sapiens_hsa051440.48589473
87Starch and sucrose metabolism_Homo sapiens_hsa005000.48204185
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.46770571
89mRNA surveillance pathway_Homo sapiens_hsa030150.46212825
90p53 signaling pathway_Homo sapiens_hsa041150.43031379
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.42280034
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40798630
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38968382
94Serotonergic synapse_Homo sapiens_hsa047260.38084405
95African trypanosomiasis_Homo sapiens_hsa051430.37220103
96Peroxisome_Homo sapiens_hsa041460.35525660
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33852860
98Tyrosine metabolism_Homo sapiens_hsa003500.31658601
99ABC transporters_Homo sapiens_hsa020100.30739485
100Collecting duct acid secretion_Homo sapiens_hsa049660.29940030

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