

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 6.31598373 |
| 2 | ribosomal small subunit biogenesis (GO:0042274) | 6.15926722 |
| 3 | viral transcription (GO:0019083) | 6.10442907 |
| 4 | translational termination (GO:0006415) | 5.94242453 |
| 5 | maturation of SSU-rRNA (GO:0030490) | 5.71491182 |
| 6 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 5.47608430 |
| 7 | cotranslational protein targeting to membrane (GO:0006613) | 5.43227477 |
| 8 | protein targeting to ER (GO:0045047) | 5.37156383 |
| 9 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 5.08381727 |
| 10 | protein localization to endoplasmic reticulum (GO:0070972) | 5.07491022 |
| 11 | translational elongation (GO:0006414) | 5.01041052 |
| 12 | ribosomal large subunit biogenesis (GO:0042273) | 4.79023215 |
| 13 | viral life cycle (GO:0019058) | 4.69163824 |
| 14 | cellular protein complex disassembly (GO:0043624) | 4.65442878 |
| 15 | proteasome assembly (GO:0043248) | 4.57561775 |
| 16 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.54298609 |
| 17 | translational initiation (GO:0006413) | 4.48454434 |
| 18 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.44339765 |
| 19 | DNA deamination (GO:0045006) | 4.41881216 |
| 20 | histone exchange (GO:0043486) | 4.23103194 |
| 21 | translation (GO:0006412) | 4.19728277 |
| 22 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.18751176 |
| 23 | ATP synthesis coupled proton transport (GO:0015986) | 4.18751176 |
| 24 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.09134073 |
| 25 | protein complex disassembly (GO:0043241) | 3.97692445 |
| 26 | CENP-A containing nucleosome assembly (GO:0034080) | 3.95902601 |
| 27 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.93670806 |
| 28 | termination of RNA polymerase III transcription (GO:0006386) | 3.85277469 |
| 29 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.85277469 |
| 30 | chromatin remodeling at centromere (GO:0031055) | 3.82360015 |
| 31 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.79991457 |
| 32 | macromolecular complex disassembly (GO:0032984) | 3.79970770 |
| 33 | 7-methylguanosine mRNA capping (GO:0006370) | 3.79186398 |
| 34 | 7-methylguanosine RNA capping (GO:0009452) | 3.76505586 |
| 35 | RNA capping (GO:0036260) | 3.76505586 |
| 36 | purine nucleobase biosynthetic process (GO:0009113) | 3.75924636 |
| 37 | mitotic metaphase plate congression (GO:0007080) | 3.75635361 |
| 38 | establishment of integrated proviral latency (GO:0075713) | 3.70744280 |
| 39 | DNA double-strand break processing (GO:0000729) | 3.69274234 |
| 40 | rRNA modification (GO:0000154) | 3.67081521 |
| 41 | telomere maintenance via recombination (GO:0000722) | 3.67007957 |
| 42 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.64720455 |
| 43 | GTP biosynthetic process (GO:0006183) | 3.63783693 |
| 44 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.63450392 |
| 45 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.63450392 |
| 46 | electron transport chain (GO:0022900) | 3.58216775 |
| 47 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.56670082 |
| 48 | rRNA processing (GO:0006364) | 3.56387428 |
| 49 | DNA replication checkpoint (GO:0000076) | 3.55247191 |
| 50 | nucleobase biosynthetic process (GO:0046112) | 3.54813708 |
| 51 | kinetochore organization (GO:0051383) | 3.54595742 |
| 52 | protein localization to kinetochore (GO:0034501) | 3.53563362 |
| 53 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.53141940 |
| 54 | kinetochore assembly (GO:0051382) | 3.49827546 |
| 55 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.49145284 |
| 56 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.49145284 |
| 57 | NADH dehydrogenase complex assembly (GO:0010257) | 3.49145284 |
| 58 | respiratory chain complex IV assembly (GO:0008535) | 3.47678350 |
| 59 | DNA strand elongation (GO:0022616) | 3.47289135 |
| 60 | cellular component biogenesis (GO:0044085) | 3.47211335 |
| 61 | chaperone-mediated protein transport (GO:0072321) | 3.46418651 |
| 62 | regulation of mitochondrial translation (GO:0070129) | 3.44339763 |
| 63 | protein targeting to membrane (GO:0006612) | 3.43997629 |
| 64 | spliceosomal snRNP assembly (GO:0000387) | 3.43625726 |
| 65 | DNA ligation (GO:0006266) | 3.43267792 |
| 66 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.42777671 |
| 67 | metaphase plate congression (GO:0051310) | 3.41442723 |
| 68 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.41185261 |
| 69 | rRNA metabolic process (GO:0016072) | 3.40573544 |
| 70 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.39640488 |
| 71 | spliceosomal complex assembly (GO:0000245) | 3.39493884 |
| 72 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.39443854 |
| 73 | mitotic recombination (GO:0006312) | 3.38926651 |
| 74 | pseudouridine synthesis (GO:0001522) | 3.35073293 |
| 75 | mRNA catabolic process (GO:0006402) | 3.34997341 |
| 76 | replication fork processing (GO:0031297) | 3.34047697 |
| 77 | protein complex biogenesis (GO:0070271) | 3.33685758 |
| 78 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.33489222 |
| 79 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.32295351 |
| 80 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.31950846 |
| 81 | DNA replication initiation (GO:0006270) | 3.31238752 |
| 82 | UTP biosynthetic process (GO:0006228) | 3.30271498 |
| 83 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.27933681 |
| 84 | protein neddylation (GO:0045116) | 3.27226748 |
| 85 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.26715624 |
| 86 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.25697171 |
| 87 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.25697171 |
| 88 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.25556849 |
| 89 | negative regulation of ligase activity (GO:0051352) | 3.25556849 |
| 90 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.24995435 |
| 91 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.23450014 |
| 92 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.20978576 |
| 93 | DNA replication-independent nucleosome organization (GO:0034724) | 3.20978576 |
| 94 | IMP biosynthetic process (GO:0006188) | 3.20529760 |
| 95 | termination of RNA polymerase I transcription (GO:0006363) | 3.19897435 |
| 96 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.18521232 |
| 97 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.18045296 |
| 98 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.18045296 |
| 99 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.17763079 |
| 100 | spindle checkpoint (GO:0031577) | 3.17473463 |
| 101 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.16970171 |
| 102 | telomere maintenance via telomere lengthening (GO:0010833) | 3.15362074 |
| 103 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.15086592 |
| 104 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.15086592 |
| 105 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.15086592 |
| 106 | mitotic sister chromatid segregation (GO:0000070) | 3.13945465 |
| 107 | histone mRNA metabolic process (GO:0008334) | 3.13811740 |
| 108 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.13540963 |
| 109 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.13323431 |
| 110 | RNA catabolic process (GO:0006401) | 3.12957744 |
| 111 | cullin deneddylation (GO:0010388) | 3.12915921 |
| 112 | cytochrome complex assembly (GO:0017004) | 3.12651428 |
| 113 | protein targeting to mitochondrion (GO:0006626) | 3.11704404 |
| 114 | formation of translation preinitiation complex (GO:0001731) | 3.11674646 |
| 115 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.11392496 |
| 116 | negative regulation of sister chromatid segregation (GO:0033046) | 3.11392496 |
| 117 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.11392496 |
| 118 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.11392496 |
| 119 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.11392496 |
| 120 | establishment of viral latency (GO:0019043) | 3.11359991 |
| 121 | maturation of 5.8S rRNA (GO:0000460) | 3.11178808 |
| 122 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.10730325 |
| 123 | rRNA methylation (GO:0031167) | 3.10613430 |
| 124 | respiratory electron transport chain (GO:0022904) | 3.10216925 |
| 125 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.09851513 |
| 126 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.09315691 |
| 127 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.08726053 |
| 128 | ribosome assembly (GO:0042255) | 3.07052949 |
| 129 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.06923863 |
| 130 | negative regulation of chromosome segregation (GO:0051985) | 3.05788204 |
| 131 | mitotic spindle checkpoint (GO:0071174) | 3.05613529 |
| 132 | transcription from RNA polymerase I promoter (GO:0006360) | 3.05330770 |
| 133 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.05184096 |
| 134 | protein deneddylation (GO:0000338) | 3.04642287 |
| 135 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.04516169 |
| 136 | positive regulation of ligase activity (GO:0051351) | 3.03993083 |
| 137 | DNA damage response, detection of DNA damage (GO:0042769) | 3.03945308 |
| 138 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.03943655 |
| 139 | protein K6-linked ubiquitination (GO:0085020) | 3.03315069 |
| 140 | non-recombinational repair (GO:0000726) | 2.99999865 |
| 141 | double-strand break repair via nonhomologous end joining (GO:0006303) | 2.99999865 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.05375313 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.85461754 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.47662754 |
| 4 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 4.40772597 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.33459218 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.11216620 |
| 7 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.65121186 |
| 8 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.36079804 |
| 9 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.32134793 |
| 10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.25476539 |
| 11 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.06834656 |
| 12 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.06375941 |
| 13 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.03864306 |
| 14 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.96778231 |
| 15 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.95219747 |
| 16 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.84230252 |
| 17 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.81759067 |
| 18 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.81705368 |
| 19 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.80064724 |
| 20 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.74741586 |
| 21 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.67479714 |
| 22 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.61059834 |
| 23 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.56150831 |
| 24 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.53742872 |
| 25 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.46090541 |
| 26 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.42582342 |
| 27 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 2.24813318 |
| 28 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.16489071 |
| 29 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.16322201 |
| 30 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.15716273 |
| 31 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.15061076 |
| 32 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.10610592 |
| 33 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.10237619 |
| 34 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.03581970 |
| 35 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.99021185 |
| 36 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.94079390 |
| 37 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.89779280 |
| 38 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.87944593 |
| 39 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.84008381 |
| 40 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.78923145 |
| 41 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.76233624 |
| 42 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.71117529 |
| 43 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.69368780 |
| 44 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.68994197 |
| 45 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.67243495 |
| 46 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.62604988 |
| 47 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.60767240 |
| 48 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.58753457 |
| 49 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.57954180 |
| 50 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.53565983 |
| 51 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.53130584 |
| 52 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.52659643 |
| 53 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.47126513 |
| 54 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.46512348 |
| 55 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.45062273 |
| 56 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.42162160 |
| 57 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.40066499 |
| 58 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.39597764 |
| 59 | VDR_22108803_ChIP-Seq_LS180_Human | 1.38335097 |
| 60 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.37479710 |
| 61 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.33855883 |
| 62 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.30905594 |
| 63 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.30517847 |
| 64 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.29707992 |
| 65 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.26204642 |
| 66 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.24443787 |
| 67 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.22518177 |
| 68 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.20002843 |
| 69 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.17511236 |
| 70 | * SPI1_23547873_ChIP-Seq_NB4_Human | 1.16593313 |
| 71 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.13965528 |
| 72 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.12615493 |
| 73 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.11930799 |
| 74 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.11892774 |
| 75 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.10863703 |
| 76 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.10291771 |
| 77 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.04457749 |
| 78 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 1.03954074 |
| 79 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.01886535 |
| 80 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.01111277 |
| 81 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.98610922 |
| 82 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.97298104 |
| 83 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.96105170 |
| 84 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.95972372 |
| 85 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.92744508 |
| 86 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.91056674 |
| 87 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.90928225 |
| 88 | EWS_26573619_Chip-Seq_HEK293_Human | 0.89585547 |
| 89 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.89342871 |
| 90 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.88275877 |
| 91 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.87205003 |
| 92 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.84640263 |
| 93 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.83784014 |
| 94 | P300_19829295_ChIP-Seq_ESCs_Human | 0.83714470 |
| 95 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.82071648 |
| 96 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.80457446 |
| 97 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.79311549 |
| 98 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.78856861 |
| 99 | FUS_26573619_Chip-Seq_HEK293_Human | 0.78851676 |
| 100 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.78842800 |
| 101 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.78221653 |
| 102 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.74592618 |
| 103 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.74292926 |
| 104 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.73810798 |
| 105 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.73704106 |
| 106 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.73549941 |
| 107 | * TP53_22573176_ChIP-Seq_HFKS_Human | 0.72760138 |
| 108 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.72426974 |
| 109 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.71063597 |
| 110 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.70229620 |
| 111 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.69641271 |
| 112 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.69284254 |
| 113 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.69166721 |
| 114 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.69068077 |
| 115 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.68669624 |
| 116 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.68369308 |
| 117 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.65758557 |
| 118 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.64076299 |
| 119 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.63209869 |
| 120 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.63138412 |
| 121 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.60575973 |
| 122 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.58821026 |
| 123 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.57854408 |
| 124 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.57550712 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.56627879 |
| 2 | MP0009379_abnormal_foot_pigmentation | 4.29278668 |
| 3 | MP0008057_abnormal_DNA_replication | 3.62966195 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 3.19606572 |
| 5 | MP0010094_abnormal_chromosome_stability | 3.13049216 |
| 6 | MP0008058_abnormal_DNA_repair | 2.84466139 |
| 7 | MP0003077_abnormal_cell_cycle | 2.82973195 |
| 8 | MP0003111_abnormal_nucleus_morphology | 2.62453567 |
| 9 | MP0003136_yellow_coat_color | 2.51808069 |
| 10 | MP0008932_abnormal_embryonic_tissue | 2.39840480 |
| 11 | MP0008007_abnormal_cellular_replicative | 2.32437953 |
| 12 | MP0006292_abnormal_olfactory_placode | 2.27447403 |
| 13 | MP0003806_abnormal_nucleotide_metabolis | 2.21504135 |
| 14 | MP0006072_abnormal_retinal_apoptosis | 2.17645709 |
| 15 | MP0000566_synostosis | 2.10276867 |
| 16 | MP0002396_abnormal_hematopoietic_system | 2.04992164 |
| 17 | MP0003786_premature_aging | 1.97753867 |
| 18 | MP0003123_paternal_imprinting | 1.93823375 |
| 19 | MP0001986_abnormal_taste_sensitivity | 1.91039336 |
| 20 | MP0005174_abnormal_tail_pigmentation | 1.88350892 |
| 21 | MP0002148_abnormal_hypersensitivity_rea | 1.86142121 |
| 22 | MP0002938_white_spotting | 1.85206831 |
| 23 | MP0000490_abnormal_crypts_of | 1.78523642 |
| 24 | MP0009785_altered_susceptibility_to | 1.77934574 |
| 25 | MP0001529_abnormal_vocalization | 1.75474039 |
| 26 | MP0003724_increased_susceptibility_to | 1.74635360 |
| 27 | MP0003718_maternal_effect | 1.69227191 |
| 28 | MP0002132_abnormal_respiratory_system | 1.68149962 |
| 29 | MP0001188_hyperpigmentation | 1.67468900 |
| 30 | MP0002102_abnormal_ear_morphology | 1.66859953 |
| 31 | MP0003186_abnormal_redox_activity | 1.66301721 |
| 32 | MP0001835_abnormal_antigen_presentation | 1.64002275 |
| 33 | MP0006035_abnormal_mitochondrial_morpho | 1.60524166 |
| 34 | MP0003890_abnormal_embryonic-extraembry | 1.54454691 |
| 35 | MP0000015_abnormal_ear_pigmentation | 1.51911883 |
| 36 | MP0001853_heart_inflammation | 1.49577251 |
| 37 | MP0008877_abnormal_DNA_methylation | 1.48379261 |
| 38 | MP0008789_abnormal_olfactory_epithelium | 1.44416521 |
| 39 | MP0009333_abnormal_splenocyte_physiolog | 1.43413882 |
| 40 | MP0004381_abnormal_hair_follicle | 1.43018225 |
| 41 | MP0002736_abnormal_nociception_after | 1.41211056 |
| 42 | MP0003763_abnormal_thymus_physiology | 1.36645436 |
| 43 | MP0003937_abnormal_limbs/digits/tail_de | 1.36175680 |
| 44 | MP0002095_abnormal_skin_pigmentation | 1.33163987 |
| 45 | MP0000372_irregular_coat_pigmentation | 1.31982159 |
| 46 | MP0003315_abnormal_perineum_morphology | 1.29964064 |
| 47 | MP0005171_absent_coat_pigmentation | 1.27956594 |
| 48 | MP0005253_abnormal_eye_physiology | 1.27044212 |
| 49 | MP0002163_abnormal_gland_morphology | 1.25134966 |
| 50 | MP0005408_hypopigmentation | 1.23587970 |
| 51 | MP0005671_abnormal_response_to | 1.22864201 |
| 52 | MP0005025_abnormal_response_to | 1.22675870 |
| 53 | MP0002638_abnormal_pupillary_reflex | 1.21239470 |
| 54 | MP0001929_abnormal_gametogenesis | 1.19121836 |
| 55 | MP0005075_abnormal_melanosome_morpholog | 1.18625595 |
| 56 | MP0001286_abnormal_eye_development | 1.15797562 |
| 57 | MP0002160_abnormal_reproductive_system | 1.15433132 |
| 58 | MP0005000_abnormal_immune_tolerance | 1.15164964 |
| 59 | MP0000049_abnormal_middle_ear | 1.14880861 |
| 60 | MP0000350_abnormal_cell_proliferation | 1.14581270 |
| 61 | MP0009697_abnormal_copulation | 1.13328470 |
| 62 | MP0004147_increased_porphyrin_level | 1.10869886 |
| 63 | MP0002420_abnormal_adaptive_immunity | 1.08247994 |
| 64 | MP0002419_abnormal_innate_immunity | 1.07456927 |
| 65 | MP0003941_abnormal_skin_development | 1.07317977 |
| 66 | MP0000358_abnormal_cell_content/ | 1.07108059 |
| 67 | MP0001819_abnormal_immune_cell | 1.06960927 |
| 68 | MP0002405_respiratory_system_inflammati | 1.06043166 |
| 69 | MP0001145_abnormal_male_reproductive | 1.05607150 |
| 70 | MP0005409_darkened_coat_color | 1.05071926 |
| 71 | MP0000858_altered_metastatic_potential | 1.04624136 |
| 72 | MP0002452_abnormal_antigen_presenting | 1.04594923 |
| 73 | MP0010030_abnormal_orbit_morphology | 1.04173663 |
| 74 | MP0000653_abnormal_sex_gland | 1.03805847 |
| 75 | MP0000313_abnormal_cell_death | 1.03245905 |
| 76 | MP0001905_abnormal_dopamine_level | 1.02770813 |
| 77 | MP0002398_abnormal_bone_marrow | 1.02638808 |
| 78 | MP0002277_abnormal_respiratory_mucosa | 1.02381017 |
| 79 | MP0002723_abnormal_immune_serum | 1.01972241 |
| 80 | MP0002084_abnormal_developmental_patter | 1.01841066 |
| 81 | MP0002233_abnormal_nose_morphology | 1.01425191 |
| 82 | MP0002085_abnormal_embryonic_tissue | 1.00826577 |
| 83 | MP0005380_embryogenesis_phenotype | 0.99595687 |
| 84 | MP0001672_abnormal_embryogenesis/_devel | 0.99595687 |
| 85 | MP0001764_abnormal_homeostasis | 0.98982721 |
| 86 | MP0002751_abnormal_autonomic_nervous | 0.98421919 |
| 87 | MP0005084_abnormal_gallbladder_morpholo | 0.98035072 |
| 88 | MP0005379_endocrine/exocrine_gland_phen | 0.97656234 |
| 89 | MP0003195_calcinosis | 0.97318551 |
| 90 | MP0000631_abnormal_neuroendocrine_gland | 0.95761430 |
| 91 | MP0003121_genomic_imprinting | 0.95455308 |
| 92 | MP0005389_reproductive_system_phenotype | 0.94966224 |
| 93 | MP0006054_spinal_hemorrhage | 0.93469095 |
| 94 | MP0004133_heterotaxia | 0.93260394 |
| 95 | MP0006036_abnormal_mitochondrial_physio | 0.92797363 |
| 96 | MP0002722_abnormal_immune_system | 0.92437712 |
| 97 | MP0001800_abnormal_humoral_immune | 0.90803062 |
| 98 | MP0005395_other_phenotype | 0.90787779 |
| 99 | MP0003011_delayed_dark_adaptation | 0.89617535 |
| 100 | MP0004215_abnormal_myocardial_fiber | 0.89508493 |
| 101 | MP0000689_abnormal_spleen_morphology | 0.89277364 |
| 102 | MP0002080_prenatal_lethality | 0.89160953 |
| 103 | MP0005551_abnormal_eye_electrophysiolog | 0.87779272 |
| 104 | MP0000716_abnormal_immune_system | 0.87572695 |
| 105 | MP0008872_abnormal_physiological_respon | 0.87295890 |
| 106 | MP0002697_abnormal_eye_size | 0.87018144 |
| 107 | MP0002234_abnormal_pharynx_morphology | 0.86576909 |
| 108 | MP0002019_abnormal_tumor_incidence | 0.85265634 |
| 109 | MP0002429_abnormal_blood_cell | 0.84677828 |
| 110 | MP0001727_abnormal_embryo_implantation | 0.84177951 |
| 111 | MP0005423_abnormal_somatic_nervous | 0.83746080 |
| 112 | MP0001919_abnormal_reproductive_system | 0.83528651 |
| 113 | MP0002090_abnormal_vision | 0.82984277 |
| 114 | MP0005394_taste/olfaction_phenotype | 0.81310104 |
| 115 | MP0005499_abnormal_olfactory_system | 0.81310104 |
| 116 | MP0001730_embryonic_growth_arrest | 0.81217335 |
| 117 | MP0002111_abnormal_tail_morphology | 0.81106949 |
| 118 | MP0000703_abnormal_thymus_morphology | 0.80761384 |
| 119 | MP0003984_embryonic_growth_retardation | 0.80136511 |
| 120 | MP0000465_gastrointestinal_hemorrhage | 0.79869434 |
| 121 | MP0002837_dystrophic_cardiac_calcinosis | 0.79226391 |
| 122 | MP0005391_vision/eye_phenotype | 0.78403537 |
| 123 | MP0002088_abnormal_embryonic_growth/wei | 0.77440953 |
| 124 | MP0000647_abnormal_sebaceous_gland | 0.76182150 |
| 125 | MP0003567_abnormal_fetal_cardiomyocyte | 0.75663112 |
| 126 | MP0003698_abnormal_male_reproductive | 0.75306912 |
| 127 | MP0002006_tumorigenesis | 0.74682887 |
| 128 | MP0002210_abnormal_sex_determination | 0.73803266 |
| 129 | MP0004808_abnormal_hematopoietic_stem | 0.72645331 |
| 130 | MP0003119_abnormal_digestive_system | 0.70914263 |
| 131 | MP0004142_abnormal_muscle_tone | 0.69959000 |
| 132 | MP0001293_anophthalmia | 0.69420954 |
| 133 | MP0008995_early_reproductive_senescence | 0.68488214 |
| 134 | MP0003436_decreased_susceptibility_to | 0.68394860 |
| 135 | MP0001485_abnormal_pinna_reflex | 0.68142172 |
| 136 | MP0002282_abnormal_trachea_morphology | 0.67761027 |
| 137 | MP0010307_abnormal_tumor_latency | 0.66998166 |
| 138 | MP0008004_abnormal_stomach_pH | 0.66088969 |
| 139 | MP0005410_abnormal_fertilization | 0.65981744 |
| 140 | MP0001346_abnormal_lacrimal_gland | 0.64754289 |
| 141 | MP0003880_abnormal_central_pattern | 0.63874721 |
| 142 | MP0005646_abnormal_pituitary_gland | 0.63436224 |
| 143 | MP0004197_abnormal_fetal_growth/weight/ | 0.62765819 |
| 144 | MP0001119_abnormal_female_reproductive | 0.62509560 |
| 145 | MP0005195_abnormal_posterior_eye | 0.62427922 |
| 146 | MP0001984_abnormal_olfaction | 0.61950559 |
| 147 | MP0001697_abnormal_embryo_size | 0.61775559 |
| 148 | MP0001542_abnormal_bone_strength | 0.59593257 |
| 149 | MP0002177_abnormal_outer_ear | 0.59516465 |
| 150 | MP0010155_abnormal_intestine_physiology | 0.59508064 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.70828105 |
| 2 | Reticulocytopenia (HP:0001896) | 5.38143077 |
| 3 | Abnormal number of erythroid precursors (HP:0012131) | 5.21638291 |
| 4 | Increased hepatocellular lipid droplets (HP:0006565) | 4.77021082 |
| 5 | Acute necrotizing encephalopathy (HP:0006965) | 4.44224378 |
| 6 | Mitochondrial inheritance (HP:0001427) | 4.32456035 |
| 7 | Lipid accumulation in hepatocytes (HP:0006561) | 4.13463638 |
| 8 | Birth length less than 3rd percentile (HP:0003561) | 3.99262890 |
| 9 | Exertional dyspnea (HP:0002875) | 3.96392568 |
| 10 | Macrocytic anemia (HP:0001972) | 3.96171881 |
| 11 | Pallor (HP:0000980) | 3.89785798 |
| 12 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.84856918 |
| 13 | Increased CSF lactate (HP:0002490) | 3.84562487 |
| 14 | Renal Fanconi syndrome (HP:0001994) | 3.84067863 |
| 15 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.75400851 |
| 16 | Progressive macrocephaly (HP:0004481) | 3.54687750 |
| 17 | Hepatocellular necrosis (HP:0001404) | 3.51188259 |
| 18 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.47799576 |
| 19 | 3-Methylglutaconic aciduria (HP:0003535) | 3.41954367 |
| 20 | Aplastic anemia (HP:0001915) | 3.34300791 |
| 21 | Acute encephalopathy (HP:0006846) | 3.25569050 |
| 22 | Respiratory difficulties (HP:0002880) | 3.24005345 |
| 23 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 3.23723046 |
| 24 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.17643876 |
| 25 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.17643876 |
| 26 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.09851967 |
| 27 | Increased intramyocellular lipid droplets (HP:0012240) | 2.97894011 |
| 28 | Hepatic necrosis (HP:0002605) | 2.96096122 |
| 29 | Increased serum lactate (HP:0002151) | 2.91094362 |
| 30 | Breast hypoplasia (HP:0003187) | 2.87750684 |
| 31 | Chromsome breakage (HP:0040012) | 2.73988268 |
| 32 | Type I transferrin isoform profile (HP:0003642) | 2.72261897 |
| 33 | Exercise intolerance (HP:0003546) | 2.71976902 |
| 34 | Microvesicular hepatic steatosis (HP:0001414) | 2.70163287 |
| 35 | Parakeratosis (HP:0001036) | 2.66488237 |
| 36 | Amniotic constriction ring (HP:0009775) | 2.65238530 |
| 37 | Abnormality of placental membranes (HP:0011409) | 2.65238530 |
| 38 | Duodenal stenosis (HP:0100867) | 2.64309299 |
| 39 | Small intestinal stenosis (HP:0012848) | 2.64309299 |
| 40 | Oral leukoplakia (HP:0002745) | 2.57086074 |
| 41 | Abnormality of the labia minora (HP:0012880) | 2.55444708 |
| 42 | Abnormal lung lobation (HP:0002101) | 2.55166738 |
| 43 | Abnormality of methionine metabolism (HP:0010901) | 2.50613069 |
| 44 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.50111524 |
| 45 | Methylmalonic acidemia (HP:0002912) | 2.43969100 |
| 46 | Duplicated collecting system (HP:0000081) | 2.42668380 |
| 47 | Abnormality of renal resorption (HP:0011038) | 2.41521223 |
| 48 | Premature graying of hair (HP:0002216) | 2.39781106 |
| 49 | 11 pairs of ribs (HP:0000878) | 2.38324395 |
| 50 | Abnormality of the duodenum (HP:0002246) | 2.36659752 |
| 51 | Abnormality of the renal collecting system (HP:0004742) | 2.35899753 |
| 52 | Respiratory failure (HP:0002878) | 2.34597192 |
| 53 | Increased muscle lipid content (HP:0009058) | 2.32143495 |
| 54 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.29331992 |
| 55 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.29124444 |
| 56 | Abnormality of alanine metabolism (HP:0010916) | 2.29124444 |
| 57 | Hyperalaninemia (HP:0003348) | 2.29124444 |
| 58 | Abnormality of the preputium (HP:0100587) | 2.28374909 |
| 59 | Rough bone trabeculation (HP:0100670) | 2.26630120 |
| 60 | Lactic acidosis (HP:0003128) | 2.25251983 |
| 61 | Type 2 muscle fiber atrophy (HP:0003554) | 2.21126853 |
| 62 | Abnormal hemoglobin (HP:0011902) | 2.20755057 |
| 63 | Abnormality of serum amino acid levels (HP:0003112) | 2.19051647 |
| 64 | Congenital, generalized hypertrichosis (HP:0004540) | 2.18413203 |
| 65 | Triphalangeal thumb (HP:0001199) | 2.16559064 |
| 66 | Patchy hypopigmentation of hair (HP:0011365) | 2.15389921 |
| 67 | Megaloblastic anemia (HP:0001889) | 2.15125573 |
| 68 | Volvulus (HP:0002580) | 2.15025636 |
| 69 | Sloping forehead (HP:0000340) | 2.14120248 |
| 70 | Muscle fiber atrophy (HP:0100295) | 2.14067752 |
| 71 | Hyperglycinemia (HP:0002154) | 2.12885108 |
| 72 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.12675184 |
| 73 | Patellar aplasia (HP:0006443) | 2.12324466 |
| 74 | Thrombocytosis (HP:0001894) | 2.11983320 |
| 75 | Clubbing of toes (HP:0100760) | 2.11226641 |
| 76 | Pancytopenia (HP:0001876) | 2.06438001 |
| 77 | Lethargy (HP:0001254) | 2.05591198 |
| 78 | Optic disc pallor (HP:0000543) | 2.05526464 |
| 79 | Abnormality of midbrain morphology (HP:0002418) | 2.05514649 |
| 80 | Molar tooth sign on MRI (HP:0002419) | 2.05514649 |
| 81 | Reduced antithrombin III activity (HP:0001976) | 2.05366323 |
| 82 | Methylmalonic aciduria (HP:0012120) | 2.03484191 |
| 83 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.00547962 |
| 84 | Septo-optic dysplasia (HP:0100842) | 2.00359453 |
| 85 | White forelock (HP:0002211) | 2.00006848 |
| 86 | Leukodystrophy (HP:0002415) | 1.99284918 |
| 87 | Increased serum pyruvate (HP:0003542) | 1.95952904 |
| 88 | Abnormality of glycolysis (HP:0004366) | 1.95952904 |
| 89 | Abnormality of the anterior horn cell (HP:0006802) | 1.95914842 |
| 90 | Degeneration of anterior horn cells (HP:0002398) | 1.95914842 |
| 91 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 1.94704290 |
| 92 | Cerebral hypomyelination (HP:0006808) | 1.94595007 |
| 93 | Hypoplastic pelvis (HP:0008839) | 1.94170675 |
| 94 | Meckel diverticulum (HP:0002245) | 1.93840388 |
| 95 | Microretrognathia (HP:0000308) | 1.93418411 |
| 96 | Severe visual impairment (HP:0001141) | 1.93112600 |
| 97 | Recurrent abscess formation (HP:0002722) | 1.91920969 |
| 98 | Duplication of thumb phalanx (HP:0009942) | 1.91810945 |
| 99 | Absent thumb (HP:0009777) | 1.90658913 |
| 100 | Partial duplication of thumb phalanx (HP:0009944) | 1.89819200 |
| 101 | Ectopic kidney (HP:0000086) | 1.89337868 |
| 102 | Abnormality of the carotid arteries (HP:0005344) | 1.89216767 |
| 103 | Abnormality of the axillary hair (HP:0100134) | 1.88517796 |
| 104 | Abnormality of secondary sexual hair (HP:0009888) | 1.88517796 |
| 105 | Pancreatic fibrosis (HP:0100732) | 1.87768888 |
| 106 | Poor head control (HP:0002421) | 1.86174561 |
| 107 | True hermaphroditism (HP:0010459) | 1.85939069 |
| 108 | Cerebral edema (HP:0002181) | 1.85719137 |
| 109 | Abnormality of the ileum (HP:0001549) | 1.85426938 |
| 110 | Stenosis of the external auditory canal (HP:0000402) | 1.85223317 |
| 111 | Neoplasm of the colon (HP:0100273) | 1.84206803 |
| 112 | Depressed nasal ridge (HP:0000457) | 1.84105515 |
| 113 | Abnormal protein glycosylation (HP:0012346) | 1.83905925 |
| 114 | Abnormal glycosylation (HP:0012345) | 1.83905925 |
| 115 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.83905925 |
| 116 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.83905925 |
| 117 | Abnormal trabecular bone morphology (HP:0100671) | 1.83457503 |
| 118 | Dyschromatopsia (HP:0007641) | 1.80397147 |
| 119 | Absent radius (HP:0003974) | 1.80321698 |
| 120 | Supernumerary spleens (HP:0009799) | 1.78016941 |
| 121 | Sparse eyelashes (HP:0000653) | 1.77676802 |
| 122 | Absent forearm bone (HP:0003953) | 1.77490857 |
| 123 | Aplasia involving forearm bones (HP:0009822) | 1.77490857 |
| 124 | Pendular nystagmus (HP:0012043) | 1.76456487 |
| 125 | Abnormality of chromosome stability (HP:0003220) | 1.76429585 |
| 126 | Pancreatic cysts (HP:0001737) | 1.76325710 |
| 127 | Bone marrow hypocellularity (HP:0005528) | 1.75718086 |
| 128 | Irregular epiphyses (HP:0010582) | 1.75616597 |
| 129 | Hypoplasia of the pons (HP:0012110) | 1.74428454 |
| 130 | Myelodysplasia (HP:0002863) | 1.73571402 |
| 131 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.73314136 |
| 132 | Colon cancer (HP:0003003) | 1.73078029 |
| 133 | Horseshoe kidney (HP:0000085) | 1.70914384 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.19652823 |
| 2 | NME2 | 4.02560513 |
| 3 | STK16 | 3.74109905 |
| 4 | VRK2 | 3.55057767 |
| 5 | EIF2AK1 | 3.45069370 |
| 6 | WEE1 | 3.16434500 |
| 7 | VRK1 | 2.68250820 |
| 8 | NEK1 | 2.58523805 |
| 9 | PBK | 2.55616718 |
| 10 | TLK1 | 2.39378655 |
| 11 | SRPK1 | 2.27953379 |
| 12 | NME1 | 2.27707154 |
| 13 | EIF2AK3 | 2.23942869 |
| 14 | CDC7 | 2.18795945 |
| 15 | CDK8 | 2.05559161 |
| 16 | TRIM28 | 2.04717485 |
| 17 | PIM2 | 1.87414658 |
| 18 | MKNK1 | 1.65256315 |
| 19 | ACVR1B | 1.63666564 |
| 20 | EIF2AK2 | 1.63118262 |
| 21 | BRSK2 | 1.61414971 |
| 22 | PLK4 | 1.58460948 |
| 23 | WNK3 | 1.58314432 |
| 24 | IRAK4 | 1.53596898 |
| 25 | BMPR1B | 1.52986341 |
| 26 | MST4 | 1.46172404 |
| 27 | TNIK | 1.39339450 |
| 28 | TAF1 | 1.34777610 |
| 29 | TESK2 | 1.28925242 |
| 30 | PNCK | 1.27751162 |
| 31 | YES1 | 1.27359990 |
| 32 | ZAK | 1.25468356 |
| 33 | IRAK3 | 1.24917130 |
| 34 | DYRK3 | 1.22605871 |
| 35 | MAP3K12 | 1.22405741 |
| 36 | TEC | 1.19651073 |
| 37 | MKNK2 | 1.18268198 |
| 38 | TAOK2 | 1.15202244 |
| 39 | PLK1 | 1.14381422 |
| 40 | BMPR2 | 1.12779415 |
| 41 | AURKB | 1.07865390 |
| 42 | CCNB1 | 1.03734123 |
| 43 | GRK7 | 1.02420677 |
| 44 | MUSK | 1.01095010 |
| 45 | TGFBR1 | 0.97312623 |
| 46 | GRK1 | 0.97131732 |
| 47 | CDK7 | 0.95570970 |
| 48 | PDK2 | 0.94790867 |
| 49 | PLK2 | 0.94044841 |
| 50 | BLK | 0.93277532 |
| 51 | RPS6KA4 | 0.93186756 |
| 52 | BRSK1 | 0.91882555 |
| 53 | TXK | 0.91763556 |
| 54 | DYRK2 | 0.91039932 |
| 55 | ATR | 0.90579671 |
| 56 | LIMK1 | 0.88598606 |
| 57 | PLK3 | 0.85774675 |
| 58 | STK3 | 0.84542065 |
| 59 | AURKA | 0.83776320 |
| 60 | TSSK6 | 0.81663240 |
| 61 | PASK | 0.80965803 |
| 62 | CSNK1G1 | 0.79435180 |
| 63 | KIT | 0.76612061 |
| 64 | SIK3 | 0.76367609 |
| 65 | BTK | 0.75769884 |
| 66 | BCKDK | 0.74489450 |
| 67 | IKBKB | 0.74383812 |
| 68 | NUAK1 | 0.73400128 |
| 69 | FRK | 0.73153587 |
| 70 | MAP4K2 | 0.72427175 |
| 71 | CSNK2A1 | 0.72112581 |
| 72 | RPS6KA5 | 0.71783963 |
| 73 | BRAF | 0.71490658 |
| 74 | STK39 | 0.70904662 |
| 75 | ERBB3 | 0.70286962 |
| 76 | MYLK | 0.69763338 |
| 77 | OXSR1 | 0.68273543 |
| 78 | MAP3K14 | 0.67440152 |
| 79 | KDR | 0.66831234 |
| 80 | ABL2 | 0.64567671 |
| 81 | ADRBK2 | 0.64278240 |
| 82 | LYN | 0.63812945 |
| 83 | TTK | 0.63805822 |
| 84 | RPS6KB2 | 0.62353549 |
| 85 | MAP3K4 | 0.62062542 |
| 86 | CDK3 | 0.60535850 |
| 87 | STK38L | 0.60471993 |
| 88 | CDK19 | 0.60014152 |
| 89 | CHEK2 | 0.59989995 |
| 90 | NEK2 | 0.59637280 |
| 91 | CSNK2A2 | 0.59107619 |
| 92 | CSNK1G2 | 0.58126355 |
| 93 | MAPK13 | 0.56728123 |
| 94 | CLK1 | 0.56488480 |
| 95 | ARAF | 0.53467786 |
| 96 | CASK | 0.52426778 |
| 97 | PAK1 | 0.52252850 |
| 98 | MAPKAPK5 | 0.51461745 |
| 99 | BCR | 0.50052395 |
| 100 | RIPK4 | 0.49584102 |
| 101 | PIM1 | 0.46677809 |
| 102 | SYK | 0.46460655 |
| 103 | INSRR | 0.46038843 |
| 104 | STK10 | 0.44983022 |
| 105 | CSNK1A1L | 0.44942421 |
| 106 | STK4 | 0.42881991 |
| 107 | CSNK1E | 0.42478128 |
| 108 | ADRBK1 | 0.41603960 |
| 109 | ALK | 0.41472962 |
| 110 | ATM | 0.41218478 |
| 111 | CHEK1 | 0.39041358 |
| 112 | MAP3K11 | 0.39002930 |
| 113 | FGFR1 | 0.38367741 |
| 114 | CDK1 | 0.37280936 |
| 115 | MAP2K7 | 0.36574575 |
| 116 | MAP4K1 | 0.36078168 |
| 117 | ILK | 0.35762670 |
| 118 | ERBB4 | 0.35414562 |
| 119 | PRPF4B | 0.35048832 |
| 120 | LCK | 0.34684133 |
| 121 | STK24 | 0.33396199 |
| 122 | PAK4 | 0.32759495 |
| 123 | PRKCG | 0.31885879 |
| 124 | NLK | 0.31565654 |
| 125 | MAP3K8 | 0.31464891 |
| 126 | TIE1 | 0.31021428 |
| 127 | PRKDC | 0.30508686 |
| 128 | TYK2 | 0.29601807 |
| 129 | JAK3 | 0.29555829 |
| 130 | CSNK1G3 | 0.29521446 |
| 131 | TESK1 | 0.29077104 |
| 132 | DAPK1 | 0.28878582 |
| 133 | LRRK2 | 0.28456132 |
| 134 | CDK2 | 0.28113291 |
| 135 | WNK4 | 0.25421335 |
| 136 | CSNK1A1 | 0.23384638 |
| 137 | MINK1 | 0.23066474 |
| 138 | PRKCE | 0.21611530 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 5.44755609 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 3.95449777 |
| 3 | DNA replication_Homo sapiens_hsa03030 | 3.71111520 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.68447119 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 3.10570610 |
| 6 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.94216541 |
| 7 | Protein export_Homo sapiens_hsa03060 | 2.86423864 |
| 8 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.80628750 |
| 9 | * Spliceosome_Homo sapiens_hsa03040 | 2.77411368 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.76671999 |
| 11 | Parkinsons disease_Homo sapiens_hsa05012 | 2.61040587 |
| 12 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.60703963 |
| 13 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.40825979 |
| 14 | Base excision repair_Homo sapiens_hsa03410 | 2.21124252 |
| 15 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.11028545 |
| 16 | Huntingtons disease_Homo sapiens_hsa05016 | 2.10558406 |
| 17 | Basal transcription factors_Homo sapiens_hsa03022 | 1.97029060 |
| 18 | * RNA transport_Homo sapiens_hsa03013 | 1.88957983 |
| 19 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.83504220 |
| 20 | Alzheimers disease_Homo sapiens_hsa05010 | 1.80078144 |
| 21 | RNA degradation_Homo sapiens_hsa03018 | 1.73502833 |
| 22 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.71413121 |
| 23 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.60840679 |
| 24 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.60059070 |
| 25 | Cell cycle_Homo sapiens_hsa04110 | 1.49450047 |
| 26 | Purine metabolism_Homo sapiens_hsa00230 | 1.43092682 |
| 27 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.35679271 |
| 28 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.34789474 |
| 29 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.28905177 |
| 30 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.20638106 |
| 31 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.17868174 |
| 32 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.14852913 |
| 33 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.08191046 |
| 34 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.05814096 |
| 35 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.02981364 |
| 36 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.98488247 |
| 37 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.96467371 |
| 38 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.93654948 |
| 39 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.93151713 |
| 40 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.91925993 |
| 41 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.91171796 |
| 42 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.89135899 |
| 43 | * mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.88096257 |
| 44 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.84282376 |
| 45 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.82682086 |
| 46 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.82255815 |
| 47 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.82060729 |
| 48 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.79116497 |
| 49 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.78288976 |
| 50 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.76986674 |
| 51 | Legionellosis_Homo sapiens_hsa05134 | 0.76270681 |
| 52 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.75499638 |
| 53 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.70517097 |
| 54 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.70204624 |
| 55 | Allograft rejection_Homo sapiens_hsa05330 | 0.68917666 |
| 56 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.68550558 |
| 57 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.66030919 |
| 58 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.65381513 |
| 59 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.64760518 |
| 60 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.62919327 |
| 61 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.62310442 |
| 62 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.59554514 |
| 63 | Asthma_Homo sapiens_hsa05310 | 0.58087414 |
| 64 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.54632099 |
| 65 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.53325382 |
| 66 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.52388176 |
| 67 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.52384267 |
| 68 | Measles_Homo sapiens_hsa05162 | 0.51921692 |
| 69 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.51635326 |
| 70 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.51480096 |
| 71 | Leishmaniasis_Homo sapiens_hsa05140 | 0.50205198 |
| 72 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.49824158 |
| 73 | Carbon metabolism_Homo sapiens_hsa01200 | 0.49223826 |
| 74 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.48921742 |
| 75 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.47948354 |
| 76 | Peroxisome_Homo sapiens_hsa04146 | 0.47637415 |
| 77 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.47151708 |
| 78 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.47050895 |
| 79 | Metabolic pathways_Homo sapiens_hsa01100 | 0.44025084 |
| 80 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.43855027 |
| 81 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.43777977 |
| 82 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.42719117 |
| 83 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.41243600 |
| 84 | Pertussis_Homo sapiens_hsa05133 | 0.40547365 |
| 85 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.40103104 |
| 86 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.39482473 |
| 87 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.38481795 |
| 88 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.38017391 |
| 89 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.36159290 |
| 90 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.35593661 |
| 91 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.34928475 |
| 92 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.34708992 |
| 93 | Malaria_Homo sapiens_hsa05144 | 0.33979689 |
| 94 | Retinol metabolism_Homo sapiens_hsa00830 | 0.33176201 |
| 95 | Phagosome_Homo sapiens_hsa04145 | 0.32990095 |
| 96 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.32724115 |
| 97 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.31574220 |
| 98 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.30698584 |
| 99 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.29604998 |
| 100 | Alcoholism_Homo sapiens_hsa05034 | 0.28180955 |
| 101 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.28168506 |
| 102 | Other glycan degradation_Homo sapiens_hsa00511 | 0.28161355 |
| 103 | Influenza A_Homo sapiens_hsa05164 | 0.28086401 |
| 104 | Sulfur relay system_Homo sapiens_hsa04122 | 0.27217018 |
| 105 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.27161430 |
| 106 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.26994030 |
| 107 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.26831543 |
| 108 | Shigellosis_Homo sapiens_hsa05131 | 0.26673816 |
| 109 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.26293453 |
| 110 | Apoptosis_Homo sapiens_hsa04210 | 0.26023810 |
| 111 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.25747670 |
| 112 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.25642445 |
| 113 | Phototransduction_Homo sapiens_hsa04744 | 0.25094223 |
| 114 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.24809305 |
| 115 | HTLV-I infection_Homo sapiens_hsa05166 | 0.24176984 |
| 116 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.22704706 |
| 117 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.22644801 |
| 118 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.22300367 |
| 119 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.21899322 |
| 120 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.21562117 |
| 121 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.21195086 |
| 122 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.20881680 |
| 123 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.20825116 |
| 124 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.20798478 |
| 125 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.20366018 |
| 126 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.19694311 |
| 127 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.18908569 |
| 128 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.18904676 |
| 129 | Salmonella infection_Homo sapiens_hsa05132 | 0.18840821 |
| 130 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.18834409 |
| 131 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.18742716 |
| 132 | Olfactory transduction_Homo sapiens_hsa04740 | 0.18711364 |
| 133 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.18227874 |
| 134 | Hepatitis B_Homo sapiens_hsa05161 | 0.18171096 |
| 135 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.15162970 |
| 136 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.15057813 |
| 137 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.14109221 |
| 138 | Tuberculosis_Homo sapiens_hsa05152 | 0.13889224 |
| 139 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.13641443 |
| 140 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.13568548 |
| 141 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.13014419 |
| 142 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.12344314 |
| 143 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.12264897 |
| 144 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.10341508 |

