MAGT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this gene cause mental retardation X-linked type 95 (MRX95). This gene may have multiple in-frame translation initiation sites, one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)6.42424236
2COPI coating of Golgi vesicle (GO:0048205)5.94386474
3Golgi transport vesicle coating (GO:0048200)5.94386474
4fatty acid elongation (GO:0030497)5.29950575
5central nervous system myelination (GO:0022010)5.21025586
6axon ensheathment in central nervous system (GO:0032291)5.21025586
7ER overload response (GO:0006983)4.73231789
8COPII vesicle coating (GO:0048208)4.72144504
9maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.55640240
10cell adhesion mediated by integrin (GO:0033627)4.46667899
11sequestering of metal ion (GO:0051238)4.36264938
12endocrine pancreas development (GO:0031018)4.32675302
13nucleotide transmembrane transport (GO:1901679)4.24955831
14L-phenylalanine catabolic process (GO:0006559)4.22200822
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.22200822
16exocrine pancreas development (GO:0031017)4.13338931
17protein maturation by protein folding (GO:0022417)4.08285558
18cholesterol biosynthetic process (GO:0006695)4.02622737
19regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.94480156
20nuclear pore complex assembly (GO:0051292)3.79400890
21ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.76233188
22protein retention in ER lumen (GO:0006621)3.74048122
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.71471813
24L-phenylalanine metabolic process (GO:0006558)3.71471813
25response to lipoprotein particle (GO:0055094)3.67109520
26long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.66995024
27intestinal cholesterol absorption (GO:0030299)3.61859698
28amyloid precursor protein metabolic process (GO:0042982)3.52947806
29myelin maintenance (GO:0043217)3.52808863
30ribosome assembly (GO:0042255)3.52570968
31sterol biosynthetic process (GO:0016126)3.51975529
32nuclear pore organization (GO:0006999)3.50719336
33UDP-N-acetylglucosamine metabolic process (GO:0006047)3.47376820
34pyrimidine-containing compound transmembrane transport (GO:0072531)3.43509193
35activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.43318234
36fatty-acyl-CoA biosynthetic process (GO:0046949)3.42190157
37hemidesmosome assembly (GO:0031581)3.39953999
38amyloid precursor protein catabolic process (GO:0042987)3.37403397
39glandular epithelial cell differentiation (GO:0002067)3.36592775
40desmosome organization (GO:0002934)3.33922873
41regulation of lipoprotein metabolic process (GO:0050746)3.31327732
42coenzyme catabolic process (GO:0009109)3.31227329
43positive regulation of nuclease activity (GO:0032075)3.29769608
44peptide hormone processing (GO:0016486)3.21224624
45type B pancreatic cell development (GO:0003323)3.17815851
46positive regulation of cellular amine metabolic process (GO:0033240)3.13088473
47endoplasmic reticulum unfolded protein response (GO:0030968)3.11383541
48retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.10579885
49iron ion import (GO:0097286)3.07793673
50long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.05442587
51cellular response to unfolded protein (GO:0034620)3.01657140
52regulation of nuclease activity (GO:0032069)3.01299095
53fatty-acyl-CoA metabolic process (GO:0035337)3.00218941
54ER-nucleus signaling pathway (GO:0006984)2.94390269
55* protein N-linked glycosylation via asparagine (GO:0018279)2.91877494
56glycosphingolipid catabolic process (GO:0046479)2.91529149
57bundle of His cell to Purkinje myocyte communication (GO:0086069)2.90197417
58regulation of metalloenzyme activity (GO:0048552)2.89577556
59regulation of transforming growth factor beta1 production (GO:0032908)2.89033655
60pore complex assembly (GO:0046931)2.88417282
61skin morphogenesis (GO:0043589)2.87750614
62retina vasculature morphogenesis in camera-type eye (GO:0061299)2.87280949
63cellular response to topologically incorrect protein (GO:0035967)2.85755872
64aromatic amino acid family catabolic process (GO:0009074)2.85333387
65* peptidyl-asparagine modification (GO:0018196)2.84653165
66regulation of transforming growth factor beta2 production (GO:0032909)2.83265400
67very long-chain fatty acid metabolic process (GO:0000038)2.82951581
68nucleotide-sugar biosynthetic process (GO:0009226)2.81042233
69glycolipid catabolic process (GO:0019377)2.80756847
70response to endoplasmic reticulum stress (GO:0034976)2.79139149
71cellular response to vitamin D (GO:0071305)2.79055833
72tyrosine metabolic process (GO:0006570)2.79007698
73* protein N-linked glycosylation (GO:0006487)2.78458007
74positive regulation of oligodendrocyte differentiation (GO:0048714)2.78334023
75cofactor catabolic process (GO:0051187)2.75748875
76intestinal absorption (GO:0050892)2.75153892
774-hydroxyproline metabolic process (GO:0019471)2.74858762
78acyl-CoA biosynthetic process (GO:0071616)2.73778481
79thioester biosynthetic process (GO:0035384)2.73778481
80wound healing, spreading of epidermal cells (GO:0035313)2.73614344
81purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.73437072
823-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.73437072
83oligosaccharide catabolic process (GO:0009313)2.73329139
84sphingosine metabolic process (GO:0006670)2.72123204
85creatine metabolic process (GO:0006600)2.71914162
86isoprenoid biosynthetic process (GO:0008299)2.71124199
87nucleotide transport (GO:0006862)2.70486888
88gap junction assembly (GO:0016264)2.69215615
89membrane protein ectodomain proteolysis (GO:0006509)2.68467217
90toxin metabolic process (GO:0009404)2.68014131
91ensheathment of neurons (GO:0007272)2.67992491
92axon ensheathment (GO:0008366)2.67992491
93response to methylmercury (GO:0051597)2.67536423
94sulfur amino acid catabolic process (GO:0000098)2.66969874
95diol metabolic process (GO:0034311)2.66510925
96GPI anchor biosynthetic process (GO:0006506)2.66382226
97mammary gland alveolus development (GO:0060749)2.63477661
98myelination (GO:0042552)2.62698358
99ER to Golgi vesicle-mediated transport (GO:0006888)2.62325341
100hormone catabolic process (GO:0042447)2.62093965
101heme transport (GO:0015886)2.61737431
102drug transmembrane transport (GO:0006855)2.60139265
103GDP-mannose metabolic process (GO:0019673)2.58970179
104negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.57910782
105folic acid-containing compound biosynthetic process (GO:0009396)2.57253600
106pinocytosis (GO:0006907)2.57081065
107response to redox state (GO:0051775)2.56672514
108regulation of type B pancreatic cell apoptotic process (GO:2000674)2.55922068
109regulation of cytokine production involved in inflammatory response (GO:1900015)2.55486984
110astrocyte differentiation (GO:0048708)2.55426431
111GPI anchor metabolic process (GO:0006505)2.54462369
112intestinal epithelial cell development (GO:0060576)2.52590402
113ceramide catabolic process (GO:0046514)2.52535892
114Sertoli cell development (GO:0060009)2.52470431
115cholesterol metabolic process (GO:0008203)2.50508986
116sphingoid metabolic process (GO:0046519)2.49676807
117peptidyl-glutamic acid carboxylation (GO:0017187)2.47474879
118protein carboxylation (GO:0018214)2.47474879
119nucleotide-sugar metabolic process (GO:0009225)2.47236499
120carbohydrate derivative transport (GO:1901264)2.43995082
121protein autoprocessing (GO:0016540)2.42619323
122phenol-containing compound catabolic process (GO:0019336)2.42326504
123transcytosis (GO:0045056)2.41433670
124leukocyte migration involved in inflammatory response (GO:0002523)2.40952285
125keratan sulfate catabolic process (GO:0042340)2.40472957
126positive regulation of endothelial cell apoptotic process (GO:2000353)2.39449721
127purine nucleobase biosynthetic process (GO:0009113)2.38585323
128endodermal cell differentiation (GO:0035987)2.36233516
129protein hydroxylation (GO:0018126)2.33997261
130cellular copper ion homeostasis (GO:0006878)2.33168124
131endothelial cell morphogenesis (GO:0001886)2.31144103
132vesicle coating (GO:0006901)2.29749591
133apoptotic cell clearance (GO:0043277)2.28931185
134regulation of transforming growth factor beta production (GO:0071634)2.23806849
135DNA strand elongation involved in DNA replication (GO:0006271)2.23623420
136negative regulation of protein activation cascade (GO:2000258)2.22982749
137peptidyl-proline hydroxylation (GO:0019511)2.21885058
138regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.20664117
139mesodermal cell differentiation (GO:0048333)2.20550823
140nucleobase biosynthetic process (GO:0046112)2.20532778
141positive regulation of immune response to tumor cell (GO:0002839)2.20333518
142regulation of immune response to tumor cell (GO:0002837)2.20333518
143regulation of response to tumor cell (GO:0002834)2.20333518
144positive regulation of response to tumor cell (GO:0002836)2.20333518
145negative regulation of complement activation (GO:0045916)2.18589585
146fibrinolysis (GO:0042730)2.18009999
147regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.17964461
148folic acid metabolic process (GO:0046655)2.17891240
149regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.17596784
150DNA strand elongation (GO:0022616)2.17506903
151ventricular cardiac muscle cell development (GO:0055015)2.15423160
152cellular protein complex localization (GO:0034629)2.14536373
153membrane lipid catabolic process (GO:0046466)2.13235025
154membrane raft organization (GO:0031579)2.12886833
155AMP metabolic process (GO:0046033)2.12747038
156zinc ion transmembrane transport (GO:0071577)2.12109065
157mitotic nuclear envelope disassembly (GO:0007077)2.12077475
158proteasome assembly (GO:0043248)2.11655241
159hyaluronan catabolic process (GO:0030214)2.10155554
160regulation of cardioblast differentiation (GO:0051890)2.09646037
161sequestering of extracellular ligand from receptor (GO:0035581)2.09379933
162regulation of translational termination (GO:0006449)2.08012347
163nucleobase-containing small molecule interconversion (GO:0015949)2.06329047
164regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.06231641
165surfactant homeostasis (GO:0043129)2.05861681
166proline biosynthetic process (GO:0006561)2.05561841
167wound healing, spreading of cells (GO:0044319)2.05056910
168mitotic sister chromatid cohesion (GO:0007064)2.05027857
169sphingolipid catabolic process (GO:0030149)2.04956561
170protein localization to endosome (GO:0036010)2.03485418
171cellular response to vitamin (GO:0071295)2.02964164
172regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.02819623
173tetrahydrofolate metabolic process (GO:0046653)2.02496273
174regulation of membrane protein ectodomain proteolysis (GO:0051043)1.98242364
175folic acid-containing compound metabolic process (GO:0006760)1.97580902
176cell redox homeostasis (GO:0045454)1.97380379
177membrane disassembly (GO:0030397)1.97119350
178nuclear envelope disassembly (GO:0051081)1.97119350

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.12797323
2E2F7_22180533_ChIP-Seq_HELA_Human5.75639394
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.99359718
4GATA1_22025678_ChIP-Seq_K562_Human3.61225320
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.18619227
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.17790524
7AR_21909140_ChIP-Seq_LNCAP_Human3.06404822
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.02861444
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.92515083
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.75954068
11STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.73231127
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.56185394
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.51989010
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.34627039
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.26125288
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.25227133
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.24074305
18SOX2_27498859_Chip-Seq_STOMACH_Mouse2.22900343
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.16515778
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.12021084
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11859429
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.06236885
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.06236885
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.06236885
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.03144460
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.96128027
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91956150
28SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.89697579
29SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.89697579
30FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.89602433
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.87932287
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84435864
33GATA4_25053715_ChIP-Seq_YYC3_Human1.77483970
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73129437
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.69866210
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.68000060
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.66603466
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.65357572
39DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.61506844
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.59287176
41SOX2_20726797_ChIP-Seq_SW620_Human1.58679611
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.57894811
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.57894811
44FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.57712247
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.55706784
46IRF1_19129219_ChIP-ChIP_H3396_Human1.55296386
47PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.53260869
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.50502961
49FOXA1_25552417_ChIP-Seq_VCAP_Human1.49753452
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.49208664
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49141717
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.48892142
53ZNF263_19887448_ChIP-Seq_K562_Human1.48875307
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47569394
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47101305
56MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46139610
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.45885336
58DCP1A_22483619_ChIP-Seq_HELA_Human1.45726959
59BRD4_25478319_ChIP-Seq_HGPS_Human1.45585481
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45453032
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45063195
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.45004381
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44184659
64AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.43733103
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37427281
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35159836
67NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34430918
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33886170
69NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33860537
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33647413
71PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33453017
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.32730147
73HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.29941054
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.29114243
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27824481
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.25792326
77ELK1_19687146_ChIP-ChIP_HELA_Human1.25274769
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25146646
79IRF8_27001747_Chip-Seq_BMDM_Mouse1.22479966
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.21827888
81CJUN_26792858_Chip-Seq_BT549_Human1.21797744
82GATA3_24758297_ChIP-Seq_MCF-7_Human1.20439789
83MYCN_18555785_ChIP-Seq_MESCs_Mouse1.19582818
84TP63_17297297_ChIP-ChIP_HaCaT_Human1.19492808
85Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.19073278
86TFEB_21752829_ChIP-Seq_HELA_Human1.18762649
87SOX17_20123909_ChIP-Seq_XEN_Mouse1.18635829
88NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.17195623
89FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.17033146
90CLOCK_20551151_ChIP-Seq_293T_Human1.13232005
91CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12038150
92MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.10058615
93* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09453104
94MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08812226
95ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08151946
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08096214
97MYC_18358816_ChIP-ChIP_MESCs_Mouse1.07704446
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07105715
99STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.06704368
100NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.06700184
101RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06699549
102P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04811764
103JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.04718485
104CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04696949
105STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04500086
106ESR1_21235772_ChIP-Seq_MCF-7_Human1.04055334
107VDR_22108803_ChIP-Seq_LS180_Human1.03953625
108SRF_21415370_ChIP-Seq_HL-1_Mouse1.03514228
109GATA6_25053715_ChIP-Seq_YYC3_Human1.03273192
110GATA2_21666600_ChIP-Seq_HMVEC_Human1.02796066
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00064677
112CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99812816
113FOXA2_19822575_ChIP-Seq_HepG2_Human0.99443403
114GATA4_21415370_ChIP-Seq_HL-1_Mouse0.99403046
115FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98856900
116IRF8_21731497_ChIP-ChIP_J774_Mouse0.98671405
117ESR1_20079471_ChIP-ChIP_T-47D_Human0.97285920
118VDR_23849224_ChIP-Seq_CD4+_Human0.97099987
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95704130
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95694570
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94889157
122MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.93448100
123FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93405126
124ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93148038
125KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92762768
126MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92473863
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92307330
128RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91398290
129ELK1_22589737_ChIP-Seq_MCF10A_Human0.91100511
130TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90768973
131HTT_18923047_ChIP-ChIP_STHdh_Human0.88811581
132PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.87609334
133TP63_23658742_ChIP-Seq_EP156T_Human0.84810476
134AR_20517297_ChIP-Seq_VCAP_Human0.83644599
135TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83121658
136SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.81065337
137GATA3_26560356_Chip-Seq_TH2_Human0.80655683
138FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.80490404
139FOXA1_21572438_ChIP-Seq_LNCaP_Human0.80410496
140SPI1_23547873_ChIP-Seq_NB4_Human0.80217444
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78922636
142CDX2_19796622_ChIP-Seq_MESCs_Mouse0.78512910
143ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77880568
144CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77189608
145EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.76649223
146POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76628062
147PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.75588626
148ERG_20517297_ChIP-Seq_VCAP_Human0.74719765

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.68748178
2MP0010352_gastrointestinal_tract_polyps3.19790086
3MP0004043_abnormal_pH_regulation2.97522652
4MP0002139_abnormal_hepatobiliary_system2.93809664
5MP0010234_abnormal_vibrissa_follicle2.83799075
6MP0005058_abnormal_lysosome_morphology2.61775395
7MP0002877_abnormal_melanocyte_morpholog2.61019852
8MP0004264_abnormal_extraembryonic_tissu2.56456039
9MP0005220_abnormal_exocrine_pancreas2.55115786
10MP0003806_abnormal_nucleotide_metabolis2.49127878
11MP0003566_abnormal_cell_adhesion2.47217885
12MP0005365_abnormal_bile_salt2.43306336
13MP0001666_abnormal_nutrient_absorption2.31175351
14MP0003183_abnormal_peptide_metabolism2.29166997
15MP0000920_abnormal_myelination2.27226716
16MP0005408_hypopigmentation2.18125596
17MP0009697_abnormal_copulation2.18032594
18MP0005085_abnormal_gallbladder_physiolo2.17665176
19MP0002693_abnormal_pancreas_physiology2.16578362
20MP0006054_spinal_hemorrhage2.16474799
21MP0008438_abnormal_cutaneous_collagen2.11192450
22MP0003705_abnormal_hypodermis_morpholog2.08076906
23MP0003941_abnormal_skin_development2.05087976
24MP0003252_abnormal_bile_duct1.98165792
25MP0001944_abnormal_pancreas_morphology1.94288145
26MP0005083_abnormal_biliary_tract1.89969132
27MP0005379_endocrine/exocrine_gland_phen1.85566604
28MP0005360_urolithiasis1.74281317
29MP0003868_abnormal_feces_composition1.72315137
30MP0010368_abnormal_lymphatic_system1.71550391
31MP0010678_abnormal_skin_adnexa1.67620054
32MP0009643_abnormal_urine_homeostasis1.65328119
33MP0003300_gastrointestinal_ulcer1.59744750
34MP0002006_tumorigenesis1.58102812
35MP0005023_abnormal_wound_healing1.57108263
36MP0008007_abnormal_cellular_replicative1.56145751
37MP0004381_abnormal_hair_follicle1.55413706
38MP0004957_abnormal_blastocyst_morpholog1.51936385
39MP0008875_abnormal_xenobiotic_pharmacok1.44250009
40MP0000462_abnormal_digestive_system1.43358740
41MP0000613_abnormal_salivary_gland1.41718443
42MP0003186_abnormal_redox_activity1.41387330
43MP0001661_extended_life_span1.38783325
44MP0003950_abnormal_plasma_membrane1.37865334
45MP0010094_abnormal_chromosome_stability1.36485053
46MP0000383_abnormal_hair_follicle1.35890923
47MP0005257_abnormal_intraocular_pressure1.35118903
48MP0000537_abnormal_urethra_morphology1.34308698
49MP0000678_abnormal_parathyroid_gland1.33376115
50MP0009840_abnormal_foam_cell1.32999979
51MP0002098_abnormal_vibrissa_morphology1.32165519
52MP0003091_abnormal_cell_migration1.28932919
53MP0005171_absent_coat_pigmentation1.25463452
54MP0005332_abnormal_amino_acid1.24270619
55MP0006082_CNS_inflammation1.22600530
56MP0003690_abnormal_glial_cell1.22483486
57MP0003283_abnormal_digestive_organ1.21683933
58MP0000372_irregular_coat_pigmentation1.19856889
59MP0009384_cardiac_valve_regurgitation1.19526569
60MP0002118_abnormal_lipid_homeostasis1.18467066
61MP0002295_abnormal_pulmonary_circulatio1.18140532
62MP0001216_abnormal_epidermal_layer1.17753474
63MP0001346_abnormal_lacrimal_gland1.17213800
64MP0008057_abnormal_DNA_replication1.15204573
65MP0002796_impaired_skin_barrier1.15127872
66MP0001915_intracranial_hemorrhage1.13839465
67MP0005165_increased_susceptibility_to1.13651390
68MP0000003_abnormal_adipose_tissue1.10421666
69MP0003724_increased_susceptibility_to1.10399229
70MP0004272_abnormal_basement_membrane1.09350264
71MP0005076_abnormal_cell_differentiation1.08979501
72MP0002896_abnormal_bone_mineralization1.07451829
73MP0000627_abnormal_mammary_gland1.04619967
74MP0010386_abnormal_urinary_bladder1.04581929
75MP0002078_abnormal_glucose_homeostasis1.03626326
76MP0002933_joint_inflammation1.02951326
77MP0005636_abnormal_mineral_homeostasis1.02662213
78MP0002138_abnormal_hepatobiliary_system1.01232775
79MP0010307_abnormal_tumor_latency1.01096449
80MP0000609_abnormal_liver_physiology1.00708121
81MP0005623_abnormal_meninges_morphology1.00460582
82MP0003111_abnormal_nucleus_morphology1.00401936
83MP0002254_reproductive_system_inflammat0.99786495
84MP0000013_abnormal_adipose_tissue0.99617065
85MP0009780_abnormal_chondrocyte_physiolo0.97982006
86MP0001765_abnormal_ion_homeostasis0.97345368
87MP0001958_emphysema0.97039944
88MP0003279_aneurysm0.96035420
89MP0008932_abnormal_embryonic_tissue0.95950084
90MP0003077_abnormal_cell_cycle0.95592126
91MP0002060_abnormal_skin_morphology0.92181288
92MP0000377_abnormal_hair_follicle0.91103936
93MP0005075_abnormal_melanosome_morpholog0.91099140
94MP0005501_abnormal_skin_physiology0.91006777
95MP0003656_abnormal_erythrocyte_physiolo0.90565121
96MP0001243_abnormal_dermal_layer0.88260911
97MP0005310_abnormal_salivary_gland0.88193924
98MP0002086_abnormal_extraembryonic_tissu0.88159636
99MP0009053_abnormal_anal_canal0.88080992
100MP0003984_embryonic_growth_retardation0.88024020
101MP0005164_abnormal_response_to0.87198064
102MP0005197_abnormal_uvea_morphology0.86287681
103MP0001853_heart_inflammation0.84963468
104MP0002088_abnormal_embryonic_growth/wei0.84440395
105MP0000163_abnormal_cartilage_morphology0.83936301
106MP0003795_abnormal_bone_structure0.83917489
107MP0003011_delayed_dark_adaptation0.83681069
108MP0004185_abnormal_adipocyte_glucose0.83670094
109MP0001672_abnormal_embryogenesis/_devel0.83358853
110MP0005380_embryogenesis_phenotype0.83358853
111MP0005503_abnormal_tendon_morphology0.83052654
112MP0002938_white_spotting0.82919057
113MP0001881_abnormal_mammary_gland0.82592762
114MP0001730_embryonic_growth_arrest0.81580129
115MP0000647_abnormal_sebaceous_gland0.80765096
116MP0001879_abnormal_lymphatic_vessel0.79852748
117MP0003448_altered_tumor_morphology0.79332931
118MP0003890_abnormal_embryonic-extraembry0.78736120
119MP0004134_abnormal_chest_morphology0.78441415
120MP0004782_abnormal_surfactant_physiolog0.78380742
121MP0003959_abnormal_lean_body0.78106223
122MP0002928_abnormal_bile_duct0.76894887
123MP0000767_abnormal_smooth_muscle0.75996247
124MP0005330_cardiomyopathy0.75534345
125MP0003136_yellow_coat_color0.75049123
126MP0003693_abnormal_embryo_hatching0.74292139
127MP0001533_abnormal_skeleton_physiology0.73528499
128MP0003172_abnormal_lysosome_physiology0.73264405
129MP0004233_abnormal_muscle_weight0.72927273
130MP0000858_altered_metastatic_potential0.72478498
131MP0003221_abnormal_cardiomyocyte_apopto0.71490958
132MP0004947_skin_inflammation0.71449972
133MP0005508_abnormal_skeleton_morphology0.70338540
134MP0003191_abnormal_cellular_cholesterol0.69977886
135MP0001191_abnormal_skin_condition0.69686286
136MP0005621_abnormal_cell_physiology0.69535906
137MP0001697_abnormal_embryo_size0.69417039
138MP0008469_abnormal_protein_level0.69388966
139MP0004084_abnormal_cardiac_muscle0.68962256
140MP0005451_abnormal_body_composition0.68664238
141MP0000762_abnormal_tongue_morphology0.68040376
142MP0000350_abnormal_cell_proliferation0.67985110
143MP0002009_preneoplasia0.67358411
144MP0010329_abnormal_lipoprotein_level0.67213678
145MP0001756_abnormal_urination0.66945096
146MP0003453_abnormal_keratinocyte_physiol0.64441822
147MP0002166_altered_tumor_susceptibility0.64255109
148MP0001299_abnormal_eye_distance/0.64101963
149MP0005000_abnormal_immune_tolerance0.63724160
150MP0002092_abnormal_eye_morphology0.63517928
151MP0000598_abnormal_liver_morphology0.62009643
152MP0000465_gastrointestinal_hemorrhage0.61755912
153MP0002419_abnormal_innate_immunity0.61748107
154MP0005275_abnormal_skin_tensile0.61399742
155MP0005319_abnormal_enzyme/_coenzyme0.60583028
156MP0005390_skeleton_phenotype0.60274843
157MP0002277_abnormal_respiratory_mucosa0.59734661

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)5.67742511
2Hypoglycemic coma (HP:0001325)4.79844599
3Hypoglycemic seizures (HP:0002173)4.48224155
4Abnormality of the intrinsic pathway (HP:0010989)4.36930404
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.31713558
6Symptomatic seizures (HP:0011145)4.19168899
7Intrahepatic cholestasis (HP:0001406)3.95713263
8Pancreatic islet-cell hyperplasia (HP:0004510)3.88214443
9Vacuolated lymphocytes (HP:0001922)3.58321917
10Abnormality of endocrine pancreas physiology (HP:0012093)3.54931563
11Abnormality of the pancreatic islet cells (HP:0006476)3.54931563
12Generalized aminoaciduria (HP:0002909)3.32221779
13Osteolytic defects of the phalanges of the hand (HP:0009771)3.27898217
14Osteolytic defects of the hand bones (HP:0009699)3.27898217
15Dysostosis multiplex (HP:0000943)3.22744299
16Arterial tortuosity (HP:0005116)3.18552119
17Abnormality of the common coagulation pathway (HP:0010990)3.10983728
18Mitral stenosis (HP:0001718)3.05238911
19Vascular tortuosity (HP:0004948)3.01915366
20Right ventricular cardiomyopathy (HP:0011663)2.97226007
21Vertebral compression fractures (HP:0002953)2.90667515
22Protrusio acetabuli (HP:0003179)2.90178894
23Fat malabsorption (HP:0002630)2.89101412
24Prolonged partial thromboplastin time (HP:0003645)2.88830208
25Conjugated hyperbilirubinemia (HP:0002908)2.88468107
26Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.83459574
27Abnormal protein glycosylation (HP:0012346)2.82938018
28Abnormal glycosylation (HP:0012345)2.82938018
29Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.82938018
30Abnormal protein N-linked glycosylation (HP:0012347)2.82938018
31Ketoacidosis (HP:0001993)2.82668546
32Reduced antithrombin III activity (HP:0001976)2.75128982
33Atrophic scars (HP:0001075)2.73631071
34Mucopolysacchariduria (HP:0008155)2.72771199
35Urinary glycosaminoglycan excretion (HP:0003541)2.72771199
36Aortic dissection (HP:0002647)2.71747565
37Cardiovascular calcification (HP:0011915)2.70595644
38Elevated alkaline phosphatase (HP:0003155)2.68066151
39Hyperglycemia (HP:0003074)2.65133458
40Neurofibrillary tangles (HP:0002185)2.61599185
41Large for gestational age (HP:0001520)2.61521594
42Type I transferrin isoform profile (HP:0003642)2.57253730
43Tetraparesis (HP:0002273)2.56611206
44Xanthomatosis (HP:0000991)2.56413139
45Abnormality of monocarboxylic acid metabolism (HP:0010996)2.55149429
46Vascular calcification (HP:0004934)2.50436116
47Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.49426907
48Protuberant abdomen (HP:0001538)2.47258190
49Abnormal enzyme/coenzyme activity (HP:0012379)2.46263921
50Hypobetalipoproteinemia (HP:0003563)2.45801400
51Abdominal distention (HP:0003270)2.45711823
52Abnormality of alkaline phosphatase activity (HP:0004379)2.45446076
53Steatorrhea (HP:0002570)2.42185102
54Selective tooth agenesis (HP:0001592)2.41957404
55Degeneration of the lateral corticospinal tracts (HP:0002314)2.38806669
56Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.38806669
57Progressive neurologic deterioration (HP:0002344)2.36111316
58Abnormality of mucopolysaccharide metabolism (HP:0011020)2.33525882
59Abnormality of polysaccharide metabolism (HP:0011012)2.33525882
60Abnormality of glycosaminoglycan metabolism (HP:0004371)2.33525882
61Parakeratosis (HP:0001036)2.30949425
62Insulin-resistant diabetes mellitus (HP:0000831)2.27461861
63Ketosis (HP:0001946)2.24917054
64Myocardial infarction (HP:0001658)2.24910043
65Abnormal foot bone ossification (HP:0010675)2.22478799
66Soft skin (HP:0000977)2.21040177
67Thoracolumbar scoliosis (HP:0002944)2.20052663
68Wormian bones (HP:0002645)2.19290169
69Hypophosphatemic rickets (HP:0004912)2.18144279
70Abnormality of the distal phalanges of the toes (HP:0010182)2.17765814
71Osteomalacia (HP:0002749)2.14875023
72Entropion (HP:0000621)2.13708724
73Aplasia/Hypoplasia of the fovea (HP:0008060)2.13194393
74Hypoplasia of the fovea (HP:0007750)2.13194393
75Abnormal tarsal ossification (HP:0008369)2.12609271
76Enlarged epiphyses (HP:0010580)2.11401533
77Spondylolisthesis (HP:0003302)2.11311470
78Follicular hyperkeratosis (HP:0007502)2.10718549
79Delayed epiphyseal ossification (HP:0002663)2.10235744
80Abnormality of methionine metabolism (HP:0010901)2.10043707
81Glycosuria (HP:0003076)2.09344744
82Abnormality of urine glucose concentration (HP:0011016)2.09344744
83Lower limb hyperreflexia (HP:0002395)2.08409986
84Skin nodule (HP:0200036)2.04361821
85Onycholysis (HP:0001806)2.03293183
86Asymmetry of the thorax (HP:0001555)2.01872156
87Syringomyelia (HP:0003396)2.00791662
88Spinal cord lesions (HP:0100561)2.00791662
89Hypophosphatemia (HP:0002148)1.99681192
90Joint hemorrhage (HP:0005261)1.97167599
91Abnormality of calcium-phosphate metabolism (HP:0100530)1.95758207
92Hypokalemia (HP:0002900)1.95730126
93Rickets (HP:0002748)1.94034442
94Abnormality of glycolipid metabolism (HP:0010969)1.92263368
95Abnormality of liposaccharide metabolism (HP:0010968)1.92263368
96Abnormality of glycosphingolipid metabolism (HP:0004343)1.92263368
97Short nail (HP:0001799)1.90040095
98Abnormality of oral frenula (HP:0000190)1.89703667
99Spastic diplegia (HP:0001264)1.89588022
100Abnormal pancreas size (HP:0012094)1.88525248
101Hypokalemic alkalosis (HP:0001949)1.88133971
102Hypolipoproteinemia (HP:0010981)1.86503908
103Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86399888
104Metaphyseal irregularity (HP:0003025)1.86235156
105Cervical subluxation (HP:0003308)1.85949920
106Sensory axonal neuropathy (HP:0003390)1.84327325
107Hepatosplenomegaly (HP:0001433)1.83545628
108Abnormal delivery (HP:0001787)1.82805087
109Abnormality of pyrimidine metabolism (HP:0004353)1.81618359
110Premature rupture of membranes (HP:0001788)1.81066789
111Late onset (HP:0003584)1.81024027
112Episodic fever (HP:0001954)1.80766456
113Bladder diverticulum (HP:0000015)1.80403684
114Hypochromic microcytic anemia (HP:0004840)1.79674268
115Hyperlipoproteinemia (HP:0010980)1.79635871
116Beaking of vertebral bodies (HP:0004568)1.76447814
117Abnormality of transition element cation homeostasis (HP:0011030)1.76024737
118Blue sclerae (HP:0000592)1.75390998
119Exocrine pancreatic insufficiency (HP:0001738)1.75375287
120Poor head control (HP:0002421)1.75348425
121Villous atrophy (HP:0011473)1.74807411
122Abnormality of small intestinal villus morphology (HP:0011472)1.74807411
123Delayed closure of the anterior fontanelle (HP:0001476)1.74071986
124Ankle contracture (HP:0006466)1.74048244
125Abnormality of aspartate family amino acid metabolism (HP:0010899)1.73745888
126Fragile skin (HP:0001030)1.73620188
127Abnormality of the acetabulum (HP:0003170)1.72304801
128Ankyloglossia (HP:0010296)1.71924889
129Abnormality of the fovea (HP:0000493)1.70396017
130Hypomagnesemia (HP:0002917)1.70266464
131Reduced subcutaneous adipose tissue (HP:0003758)1.69651917
132Pancreatitis (HP:0001733)1.69632411
133Hypothermia (HP:0002045)1.69476597
134Deep philtrum (HP:0002002)1.68906329
135Increased neuronal autofluorescent lipopigment (HP:0002074)1.68629890
136Elbow flexion contracture (HP:0002987)1.68530327
137Autoamputation (HP:0001218)1.68523663
138Pterygium (HP:0001059)1.67803938
139Enlarged kidneys (HP:0000105)1.67792238
140Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.67490303
141Chromsome breakage (HP:0040012)1.66532123
142Abnormality of glutamine family amino acid metabolism (HP:0010902)1.66496543
143Congenital sensorineural hearing impairment (HP:0008527)1.65583325
144Abnormality of sulfur amino acid metabolism (HP:0004339)1.65513998
145Aplasia/Hypoplasia affecting the retina (HP:0008061)1.65492499
146Aplasia/hypoplasia of the uterus (HP:0008684)1.65377881
147Proximal tubulopathy (HP:0000114)1.65281390
148Thin bony cortex (HP:0002753)1.65263158
149Abnormality of the umbilical cord (HP:0010881)1.64971612
150Dilatation of the ascending aorta (HP:0005111)1.63702472
151Delayed cranial suture closure (HP:0000270)1.63655628
152Alopecia of scalp (HP:0002293)1.63480899
153Coarse hair (HP:0002208)1.62631607
154Short middle phalanx of the 5th finger (HP:0004220)1.62536807
155Deviation of the thumb (HP:0009603)1.62207122
156Subacute progressive viral hepatitis (HP:0006572)1.61442060
157Hematochezia (HP:0002573)1.60683396
158Orthostatic hypotension (HP:0001278)1.60283001
159Hypokinesia (HP:0002375)1.60270662
160Deep venous thrombosis (HP:0002625)1.59951087
161Periodontitis (HP:0000704)1.59414588
162Hepatocellular carcinoma (HP:0001402)1.57808599
163Abnormalities of placenta or umbilical cord (HP:0001194)1.57806036
164Chondrocalcinosis (HP:0000934)1.57154555
165Abnormality of proline metabolism (HP:0010907)1.56933827
166Hydroxyprolinuria (HP:0003080)1.56933827
167Fragile nails (HP:0001808)1.56400461
168Dry hair (HP:0011359)1.55770237
169Microglossia (HP:0000171)1.55705802
170Plantar hyperkeratosis (HP:0007556)1.53026980
171Abnormality of Sharpey fibers (HP:0100685)1.52796097
172Sparse eyelashes (HP:0000653)1.52576707
173Vertebral hypoplasia (HP:0008417)1.52377710
174Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.52377710
175Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.52372620
176Abnormality of carpal bone ossification (HP:0006257)1.50017592
177Aortic aneurysm (HP:0004942)1.49503783
178Thick nail (HP:0001805)1.48593364
179Mitral valve prolapse (HP:0001634)1.48393203
180Short humerus (HP:0005792)1.48192515
181Abnormality of the anterior horn cell (HP:0006802)1.45140077
182Degeneration of anterior horn cells (HP:0002398)1.45140077
183Back pain (HP:0003418)1.45017963

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.81401775
2TAOK33.44083646
3STK393.30267747
4ERN12.99520169
5EPHB12.97353029
6FRK2.82642453
7MET2.67870918
8EPHA22.61866683
9EIF2AK12.09495466
10PASK2.09044344
11MAPK152.06009301
12WNK41.95619837
13MST41.92685278
14PAK41.91272562
15HIPK21.90877071
16EIF2AK31.84807014
17IRAK31.82960262
18PBK1.80108609
19OXSR11.75425312
20BCKDK1.72711738
21FLT31.71002753
22IRAK41.61549585
23MAPKAPK51.51662659
24NEK11.50430850
25WNK11.49962730
26STK38L1.48722725
27MST1R1.44656663
28BUB11.44182879
29WEE11.43890630
30EPHA31.41714910
31SRPK11.38210071
32MAP3K21.37537239
33TSSK61.37534116
34TTK1.36453777
35FGFR21.35579682
36ERBB31.34746467
37FER1.34340437
38MYLK1.32135221
39ACVR1B1.29691092
40STK241.29352558
41NUAK11.29183733
42IRAK11.28896686
43PIK3CG1.22814955
44NTRK11.21333657
45TTN1.17850472
46MAP3K141.16784155
47CDC71.15363848
48JAK11.13171193
49MAP2K21.11788348
50TGFBR11.10783306
51BRSK21.10073029
52CSF1R1.10039816
53ITK1.07380966
54PKN11.05408974
55TIE11.03618133
56CDK61.02772486
57BMPR1B1.00376585
58TGFBR20.99444586
59MELK0.99406535
60SCYL20.97649445
61MAP3K120.97235926
62IRAK20.97067594
63PDK20.96645697
64SIK10.96537473
65STK160.94959810
66MAP3K30.94234565
67BCR0.91098264
68CDK120.90911227
69NLK0.89984529
70PLK30.87892472
71BLK0.87650380
72ZAK0.86538461
73STK100.86430892
74CSNK1A1L0.86268108
75BMPR20.85241885
76GRK10.84659203
77TEC0.83528413
78TAF10.80137486
79PLK20.80060233
80TRPM70.76300502
81LATS10.75619728
82NME20.75570815
83EEF2K0.75513087
84TESK20.75094789
85GSK3A0.74413865
86MAP3K130.72106127
87LMTK20.71924361
88UHMK10.71183455
89MAP3K80.70140681
90CSK0.69980665
91CSNK1G10.69864724
92PIK3CA0.69579239
93SMG10.69425444
94FGFR10.69408132
95CDK80.65679390
96CSNK1G30.65384503
97PRKCQ0.62942936
98PKN20.61859374
99GRK70.61335210
100RPS6KB20.61053317
101CDK70.60686753
102AURKB0.60622684
103LATS20.60306044
104DDR20.60185768
105EPHB20.59448838
106CLK10.57933086
107BTK0.55757853
108MOS0.55671946
109PTK20.55630116
110IGF1R0.55199101
111PTK60.54629782
112NEK90.53275272
113FGFR40.52858265
114VRK10.52738746
115CAMK2D0.52172759
116PRKD10.51838533
117IKBKB0.51687941
118TESK10.51522054
119RPS6KA50.51419842
120NEK60.50909849
121ADRBK20.50378238
122PLK10.49950506
123JAK30.49928054
124YES10.48922492
125GRK50.48862222
126PAK30.48861192
127ABL20.47649043
128STK40.47611506
129PRKG20.47424876
130CAMKK20.46751281
131PLK40.46675266
132MAPK70.46637987
133DYRK1B0.46191316
134AKT30.46011972
135LIMK10.45680851
136CHUK0.45113531
137PRKCE0.44038741
138CHEK20.43650708
139JAK20.42689124
140TYK20.42332062
141MAPKAPK30.42295006
142ERBB40.41573846
143STK30.41539973
144LCK0.41129696
145VRK20.41001590
146TBK10.40871252
147TLK10.39885683
148FGFR30.39834225
149PDGFRA0.39796998
150PAK20.38834894
151ILK0.37941146
152PDGFRB0.35660611
153MKNK10.33928767
154EIF2AK20.33035262
155PRKAA20.32730806
156MAP3K10.32074022
157MAPKAPK20.31998086

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.63085210
2Maturity onset diabetes of the young_Homo sapiens_hsa049505.06113094
3Sulfur metabolism_Homo sapiens_hsa009203.76145244
4Steroid biosynthesis_Homo sapiens_hsa001003.36447675
5Fatty acid elongation_Homo sapiens_hsa000622.95519498
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.91172161
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.50322485
8Histidine metabolism_Homo sapiens_hsa003402.07374184
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01302398
10Proteasome_Homo sapiens_hsa030501.98764290
11Folate biosynthesis_Homo sapiens_hsa007901.96540724
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89827561
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.89672185
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.72840614
15Other glycan degradation_Homo sapiens_hsa005111.72260825
16DNA replication_Homo sapiens_hsa030301.71553996
17Tryptophan metabolism_Homo sapiens_hsa003801.70522790
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.67329652
19Selenocompound metabolism_Homo sapiens_hsa004501.67074824
20Linoleic acid metabolism_Homo sapiens_hsa005911.66780514
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.57593776
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57439787
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54697396
24Ether lipid metabolism_Homo sapiens_hsa005651.52989243
25Mismatch repair_Homo sapiens_hsa034301.49822176
26Sphingolipid metabolism_Homo sapiens_hsa006001.49305026
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48287724
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.45942462
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42476462
30Lysosome_Homo sapiens_hsa041421.36700903
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34179179
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.32858058
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30465009
34Small cell lung cancer_Homo sapiens_hsa052221.29162709
35Nucleotide excision repair_Homo sapiens_hsa034201.28382043
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.26741456
37Butanoate metabolism_Homo sapiens_hsa006501.24285631
38Peroxisome_Homo sapiens_hsa041461.20173523
39Fat digestion and absorption_Homo sapiens_hsa049751.19842561
40N-Glycan biosynthesis_Homo sapiens_hsa005101.19663012
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19137950
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16901392
43Arachidonic acid metabolism_Homo sapiens_hsa005901.12799020
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.12281657
45Nitrogen metabolism_Homo sapiens_hsa009101.11809279
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10116065
47ABC transporters_Homo sapiens_hsa020101.05653536
48Vitamin B6 metabolism_Homo sapiens_hsa007501.05632329
49Arginine and proline metabolism_Homo sapiens_hsa003301.04643862
50Biosynthesis of amino acids_Homo sapiens_hsa012301.03067931
51Fatty acid degradation_Homo sapiens_hsa000711.02449979
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.01531954
53Starch and sucrose metabolism_Homo sapiens_hsa005001.00794195
54Pyruvate metabolism_Homo sapiens_hsa006200.98722933
55Chemical carcinogenesis_Homo sapiens_hsa052040.97585476
56Bladder cancer_Homo sapiens_hsa052190.96601921
57Complement and coagulation cascades_Homo sapiens_hsa046100.96499866
58p53 signaling pathway_Homo sapiens_hsa041150.95716058
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.95666263
60Fatty acid metabolism_Homo sapiens_hsa012120.91993473
61Vitamin digestion and absorption_Homo sapiens_hsa049770.91841046
62Cell cycle_Homo sapiens_hsa041100.90394382
63Propanoate metabolism_Homo sapiens_hsa006400.89832588
64Proteoglycans in cancer_Homo sapiens_hsa052050.89552397
65Protein digestion and absorption_Homo sapiens_hsa049740.89547740
66TGF-beta signaling pathway_Homo sapiens_hsa043500.89003729
67Tyrosine metabolism_Homo sapiens_hsa003500.87691810
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86878165
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.86655803
70Carbon metabolism_Homo sapiens_hsa012000.85669128
71Thyroid cancer_Homo sapiens_hsa052160.85254302
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82906595
73Retinol metabolism_Homo sapiens_hsa008300.79452016
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78728926
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77787440
76Glutathione metabolism_Homo sapiens_hsa004800.77016083
77Focal adhesion_Homo sapiens_hsa045100.74628012
78Pyrimidine metabolism_Homo sapiens_hsa002400.72836679
79RNA transport_Homo sapiens_hsa030130.71384844
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70729663
81Pancreatic secretion_Homo sapiens_hsa049720.69179323
82Pentose phosphate pathway_Homo sapiens_hsa000300.68065534
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67736710
84Staphylococcus aureus infection_Homo sapiens_hsa051500.67309754
85Adherens junction_Homo sapiens_hsa045200.66363305
86Homologous recombination_Homo sapiens_hsa034400.65118108
87Vibrio cholerae infection_Homo sapiens_hsa051100.63842502
88Renin-angiotensin system_Homo sapiens_hsa046140.63004970
89beta-Alanine metabolism_Homo sapiens_hsa004100.62728120
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62360728
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.58573383
92Arginine biosynthesis_Homo sapiens_hsa002200.58503906
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57591744
94Shigellosis_Homo sapiens_hsa051310.57211438
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56233618
96Metabolic pathways_Homo sapiens_hsa011000.55066707
97Amoebiasis_Homo sapiens_hsa051460.54414444
98Phenylalanine metabolism_Homo sapiens_hsa003600.53759921
99Pancreatic cancer_Homo sapiens_hsa052120.50971276
100MicroRNAs in cancer_Homo sapiens_hsa052060.50133987
101Systemic lupus erythematosus_Homo sapiens_hsa053220.49967103
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49654663
103Fructose and mannose metabolism_Homo sapiens_hsa000510.49014911
104Galactose metabolism_Homo sapiens_hsa000520.48869721
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.48156915
106One carbon pool by folate_Homo sapiens_hsa006700.46590292
107Viral carcinogenesis_Homo sapiens_hsa052030.45193017
108Prostate cancer_Homo sapiens_hsa052150.43046798
109Toxoplasmosis_Homo sapiens_hsa051450.42679402
110Fatty acid biosynthesis_Homo sapiens_hsa000610.42577890
111Caffeine metabolism_Homo sapiens_hsa002320.40280341
112PPAR signaling pathway_Homo sapiens_hsa033200.39598564
113Non-homologous end-joining_Homo sapiens_hsa034500.38127255
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37420293
115ECM-receptor interaction_Homo sapiens_hsa045120.35707012
116Regulation of autophagy_Homo sapiens_hsa041400.32704985
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.32207105
118Antigen processing and presentation_Homo sapiens_hsa046120.31265528
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31258479
120Type I diabetes mellitus_Homo sapiens_hsa049400.30454358
121Phagosome_Homo sapiens_hsa041450.29291286
122Lysine degradation_Homo sapiens_hsa003100.29250051
123Malaria_Homo sapiens_hsa051440.27891606
124Glycerolipid metabolism_Homo sapiens_hsa005610.27261821
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25360357
126Thyroid hormone synthesis_Homo sapiens_hsa049180.24596988
127Mineral absorption_Homo sapiens_hsa049780.23820501
128Prion diseases_Homo sapiens_hsa050200.23507779
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23477789
130Ovarian steroidogenesis_Homo sapiens_hsa049130.22371706
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19688418
132Legionellosis_Homo sapiens_hsa051340.18831587
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.16991336
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.16965409
135Pertussis_Homo sapiens_hsa051330.16435998
136Hematopoietic cell lineage_Homo sapiens_hsa046400.16162601
137Autoimmune thyroid disease_Homo sapiens_hsa053200.14822079
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13816144
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10631140
140Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.10612666
141Insulin resistance_Homo sapiens_hsa049310.10558605

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »