MAK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. Mutations in this gene have been associated with ciliary defects resulting in retinitis pigmentosa 62. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1eye photoreceptor cell development (GO:0042462)9.74664124
2detection of light stimulus involved in visual perception (GO:0050908)9.63727600
3detection of light stimulus involved in sensory perception (GO:0050962)9.63727600
4* photoreceptor cell maintenance (GO:0045494)9.32300536
5phototransduction (GO:0007602)8.36597751
6phototransduction, visible light (GO:0007603)8.21576559
7detection of light stimulus (GO:0009583)8.04241458
8detection of visible light (GO:0009584)8.03712096
9positive regulation of guanylate cyclase activity (GO:0031284)7.82813307
10retinal rod cell development (GO:0046548)7.81646768
11protein-chromophore linkage (GO:0018298)7.62938506
12GMP metabolic process (GO:0046037)7.60932163
13visual perception (GO:0007601)7.17828441
14cilium or flagellum-dependent cell motility (GO:0001539)7.11219386
15sensory perception of light stimulus (GO:0050953)7.10363372
16regulation of guanylate cyclase activity (GO:0031282)7.03671939
17axonemal dynein complex assembly (GO:0070286)6.05189006
18sperm motility (GO:0030317)5.94456679
19motile cilium assembly (GO:0044458)5.87383896
20epithelial cilium movement (GO:0003351)5.80451188
21cellular response to light stimulus (GO:0071482)5.79533866
22photoreceptor cell differentiation (GO:0046530)5.77929763
23eye photoreceptor cell differentiation (GO:0001754)5.77929763
24retina development in camera-type eye (GO:0060041)5.74730129
25detection of external stimulus (GO:0009581)5.64715908
26fusion of sperm to egg plasma membrane (GO:0007342)5.61369413
27detection of abiotic stimulus (GO:0009582)5.53960101
28cilium movement (GO:0003341)5.50832270
29regulation of cilium movement (GO:0003352)5.44895903
30nonmotile primary cilium assembly (GO:0035058)5.15893195
31axoneme assembly (GO:0035082)5.13388289
32regulation of cGMP metabolic process (GO:0030823)4.93350561
33acrosome reaction (GO:0007340)4.91421314
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.91108894
35centriole replication (GO:0007099)4.81885420
36positive regulation of cGMP biosynthetic process (GO:0030828)4.70927349
37multicellular organism reproduction (GO:0032504)4.65523122
38acrosome assembly (GO:0001675)4.60562670
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.58885043
40sperm-egg recognition (GO:0035036)4.53304537
41cell wall macromolecule metabolic process (GO:0044036)4.51054078
42cell wall macromolecule catabolic process (GO:0016998)4.51054078
43plasma membrane fusion (GO:0045026)4.45257412
44neural tube formation (GO:0001841)4.43956864
45regulation of cGMP biosynthetic process (GO:0030826)4.39890177
46spermatid development (GO:0007286)4.22886289
47positive regulation of cGMP metabolic process (GO:0030825)4.11690869
48centriole assembly (GO:0098534)4.09040035
49piRNA metabolic process (GO:0034587)4.07634539
50binding of sperm to zona pellucida (GO:0007339)4.01533050
51cell-cell recognition (GO:0009988)4.01081016
52protein localization to cilium (GO:0061512)3.89482082
53detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.81808698
54male meiosis (GO:0007140)3.72836203
55establishment of protein localization to Golgi (GO:0072600)3.72104676
56reproduction (GO:0000003)3.71812675
57left/right axis specification (GO:0070986)3.71213924
58cellular response to radiation (GO:0071478)3.70445232
59cellular component assembly involved in morphogenesis (GO:0010927)3.59289141
60positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.57328310
61ventricular system development (GO:0021591)3.57188523
62receptor guanylyl cyclase signaling pathway (GO:0007168)3.56132889
63sensory perception (GO:0007600)3.53190417
64regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.52161206
65protein targeting to Golgi (GO:0000042)3.49971641
66cilium organization (GO:0044782)3.49967870
67microtubule depolymerization (GO:0007019)3.43394590
68positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.42825418
69negative regulation of translation, ncRNA-mediated (GO:0040033)3.38793080
70regulation of translation, ncRNA-mediated (GO:0045974)3.38793080
71negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.38793080
72response to pheromone (GO:0019236)3.38687348
73intraciliary transport (GO:0042073)3.38499977
74microtubule bundle formation (GO:0001578)3.38494711
75adaptation of signaling pathway (GO:0023058)3.35195456
76synaptonemal complex organization (GO:0070193)3.31446646
77single fertilization (GO:0007338)3.30306817
78cilium assembly (GO:0042384)3.26432863
79regulation of voltage-gated calcium channel activity (GO:1901385)3.24436236
80response to light stimulus (GO:0009416)3.24281102
81CDP-diacylglycerol biosynthetic process (GO:0016024)3.20608783
82sperm capacitation (GO:0048240)3.19332725
83left/right pattern formation (GO:0060972)3.19100474
84microtubule severing (GO:0051013)3.16588509
85regulation of microtubule-based movement (GO:0060632)3.16041542
86retrograde transport, vesicle recycling within Golgi (GO:0000301)3.15713000
87regulation of clathrin-mediated endocytosis (GO:2000369)3.15414707
88protein localization to synapse (GO:0035418)3.13441589
89synaptonemal complex assembly (GO:0007130)3.09928237
90peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.09648401
91intra-S DNA damage checkpoint (GO:0031573)3.09395707
92fucose catabolic process (GO:0019317)3.07812093
93L-fucose metabolic process (GO:0042354)3.07812093
94L-fucose catabolic process (GO:0042355)3.07812093
95cell morphogenesis involved in neuron differentiation (GO:0048667)3.07099325
96somite rostral/caudal axis specification (GO:0032525)3.06902922
97smoothened signaling pathway (GO:0007224)3.06094210
98negative regulation of inclusion body assembly (GO:0090084)3.05643226
99positive regulation of gastrulation (GO:2000543)3.00551001
100neuron development (GO:0048666)2.99489817
101protein polyglutamylation (GO:0018095)2.98957767
102retina layer formation (GO:0010842)2.97663335
103cilium morphogenesis (GO:0060271)2.96611818
104behavioral response to nicotine (GO:0035095)2.94323302
105response to histamine (GO:0034776)2.93769492
106regulation of short-term neuronal synaptic plasticity (GO:0048172)2.90846847
107fertilization (GO:0009566)2.89321334
108microtubule polymerization or depolymerization (GO:0031109)2.88363682
109regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.88361461
110regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.88361461
111lactate metabolic process (GO:0006089)2.87956477
112rRNA catabolic process (GO:0016075)2.86302059
113CDP-diacylglycerol metabolic process (GO:0046341)2.86296799
114negative regulation of immunoglobulin mediated immune response (GO:0002890)2.85693022
115negative regulation of B cell mediated immunity (GO:0002713)2.85693022
116sensory perception of smell (GO:0007608)2.85532689
117cell projection assembly (GO:0030031)2.85130466
118regulation of collateral sprouting (GO:0048670)2.84974154
119phospholipid translocation (GO:0045332)2.81035232
120lipid translocation (GO:0034204)2.81035232
121negative regulation of transcription regulatory region DNA binding (GO:2000678)2.80713857
122* spermatogenesis (GO:0007283)2.80666034
123detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.80283105
124* male gamete generation (GO:0048232)2.79433231
125determination of left/right symmetry (GO:0007368)2.78892004
126DNA methylation involved in gamete generation (GO:0043046)2.78407528
127G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.77191283
128limb bud formation (GO:0060174)2.76260865
129replication fork processing (GO:0031297)2.73213457
130negative regulation of mast cell activation (GO:0033004)2.72390141
131protein localization to Golgi apparatus (GO:0034067)2.65660342
132regulation of mesoderm development (GO:2000380)2.64869438
133histone mRNA catabolic process (GO:0071044)2.63892343
134somite development (GO:0061053)2.63835850
135microtubule-based movement (GO:0007018)2.62797387
136determination of bilateral symmetry (GO:0009855)2.60457662
137neuron fate determination (GO:0048664)2.58693488
138negative regulation of astrocyte differentiation (GO:0048712)2.57826836
139specification of symmetry (GO:0009799)2.55865554
140male meiosis I (GO:0007141)2.53898345
141olfactory bulb development (GO:0021772)2.53819403
142forebrain neuron differentiation (GO:0021879)2.51983623
143regulation of meiosis I (GO:0060631)2.50473062
144seminiferous tubule development (GO:0072520)2.49573313
145positive regulation of oligodendrocyte differentiation (GO:0048714)2.47511918
146detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.47045173
147spinal cord motor neuron differentiation (GO:0021522)2.44775749
148single strand break repair (GO:0000012)2.44255786
149retinal ganglion cell axon guidance (GO:0031290)2.43712817
150meiotic cell cycle (GO:0051321)2.41761278
151gamma-aminobutyric acid transport (GO:0015812)2.39991708
152limb development (GO:0060173)2.39451620
153appendage development (GO:0048736)2.39451620
154protein K11-linked deubiquitination (GO:0035871)2.37057685
155presynaptic membrane assembly (GO:0097105)2.32100049
156pyrimidine nucleobase catabolic process (GO:0006208)2.30631256
157activated T cell proliferation (GO:0050798)2.29906481
158regulation of hippo signaling (GO:0035330)2.28411290
159DNA integration (GO:0015074)2.28045883
160DNA demethylation (GO:0080111)2.24965271
161regulation of rhodopsin mediated signaling pathway (GO:0022400)13.9710536
162rhodopsin mediated signaling pathway (GO:0016056)13.6203923
163retinal cone cell development (GO:0046549)12.5115731
164photoreceptor cell development (GO:0042461)10.1061539

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.87875980
2EZH2_22144423_ChIP-Seq_EOC_Human3.16120455
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.03025840
4VDR_22108803_ChIP-Seq_LS180_Human2.98898169
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.63367457
6CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.49214804
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48914235
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42312733
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.31538499
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.28868188
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23539145
12TAF15_26573619_Chip-Seq_HEK293_Human2.11970723
13EWS_26573619_Chip-Seq_HEK293_Human1.98256463
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.94282859
15REST_21632747_ChIP-Seq_MESCs_Mouse1.92046489
16GBX2_23144817_ChIP-Seq_PC3_Human1.89752703
17IGF1R_20145208_ChIP-Seq_DFB_Human1.86617474
18GATA1_26923725_Chip-Seq_HPCs_Mouse1.82991637
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82425215
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78119996
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78013183
22UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.77223599
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.76047337
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75644741
25ELK4_26923725_Chip-Seq_MESODERM_Mouse1.73232823
26WDR5_24793694_ChIP-Seq_LNCAP_Human1.62309212
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62019502
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60995073
29DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.60500918
30DROSHA_22980978_ChIP-Seq_HELA_Human1.58214195
31AR_25329375_ChIP-Seq_VCAP_Human1.54660890
32NR3C1_21868756_ChIP-Seq_MCF10A_Human1.52044873
33TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.51848160
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49916753
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.47879284
36POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46719479
37MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.46414130
38RUNX2_22187159_ChIP-Seq_PCA_Human1.45791975
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44422083
40RNF2_27304074_Chip-Seq_NSC_Mouse1.44083110
41AR_21572438_ChIP-Seq_LNCaP_Human1.43576678
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42674190
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38750166
44TBL1_22424771_ChIP-Seq_293T_Human1.37926820
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37712361
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37712361
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37394502
48SMAD4_21799915_ChIP-Seq_A2780_Human1.37311278
49PRDM14_20953172_ChIP-Seq_ESCs_Human1.37079545
50TCF4_22108803_ChIP-Seq_LS180_Human1.36930348
51SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34729965
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.34250340
53* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33817684
54CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33574987
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31831543
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31184466
57TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.30270548
58SOX2_19829295_ChIP-Seq_ESCs_Human1.29050342
59NANOG_19829295_ChIP-Seq_ESCs_Human1.29050342
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.28628249
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28611816
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27886742
63CBP_20019798_ChIP-Seq_JUKART_Human1.27689105
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27689105
65* EZH2_27294783_Chip-Seq_ESCs_Mouse1.24723516
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24657173
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23106951
68IRF1_19129219_ChIP-ChIP_H3396_Human1.22964965
69STAT1_17558387_ChIP-Seq_HELA_Human1.22936545
70GF1_26923725_Chip-Seq_HPCs_Mouse1.22797270
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22459483
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.21554092
73CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.21406694
74NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.20888596
75KDM2B_26808549_Chip-Seq_REH_Human1.20873034
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20428791
77TP53_22573176_ChIP-Seq_HFKS_Human1.20369893
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.20152670
79BCAT_22108803_ChIP-Seq_LS180_Human1.19822541
80RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19810140
81TCF4_23295773_ChIP-Seq_U87_Human1.18024290
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.18016029
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.16879497
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14762899
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14270829
86SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13675385
87FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13507079
88ER_23166858_ChIP-Seq_MCF-7_Human1.12990783
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12241552
90STAT3_23295773_ChIP-Seq_U87_Human1.12182298
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.12089898
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12030645
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11836906
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.11559408
95ZNF274_21170338_ChIP-Seq_K562_Hela1.11544062
96* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11132816
97GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11054090
98GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.11034435
99FOXA1_25329375_ChIP-Seq_VCAP_Human1.10928498
100FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10928498
101RARB_27405468_Chip-Seq_BRAIN_Mouse1.09980006
102P53_22387025_ChIP-Seq_ESCs_Mouse1.09393436
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09287188
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09051442
105TP63_19390658_ChIP-ChIP_HaCaT_Human1.08707746
106ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08674292
107FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08246972
108AHR_22903824_ChIP-Seq_MCF-7_Human1.07888437
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07673465
110TP53_16413492_ChIP-PET_HCT116_Human1.07604412
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06917852
112E2F1_18555785_Chip-Seq_ESCs_Mouse1.06780035
113SMAD3_21741376_ChIP-Seq_ESCs_Human1.06408283
114HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06251819
115SMAD3_21741376_ChIP-Seq_HESCs_Human1.05777288
116CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05344509
117SMRT_27268052_Chip-Seq_Bcells_Human1.04934674
118KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04379729
119GF1B_26923725_Chip-Seq_HPCs_Mouse1.04260759
120P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03604223
121JUN_21703547_ChIP-Seq_K562_Human1.02962508
122PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02843781
123CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02228587
124CDX2_22108803_ChIP-Seq_LS180_Human1.02126301
125AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01381960
126FUS_26573619_Chip-Seq_HEK293_Human1.00192868
127PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.97769144
128LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.97213798
129MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97128238
130AR_19668381_ChIP-Seq_PC3_Human0.96027850
131SOX9_26525672_Chip-Seq_HEART_Mouse0.95304974
132ETV1_20927104_ChIP-Seq_GIST48_Human0.95155245
133NFYB_21822215_ChIP-Seq_K562_Human0.95011790
134OCT1_27270436_Chip-Seq_PROSTATE_Human0.94933222
135P300_19829295_ChIP-Seq_ESCs_Human0.94864135
136SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93965350
137SMAD4_21741376_ChIP-Seq_EPCs_Human0.92818742
138RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92247301
139RNF2_27304074_Chip-Seq_ESCs_Mouse0.92197649
140NFE2_27457419_Chip-Seq_LIVER_Mouse0.91633894
141EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90310552
142CBP_21632823_ChIP-Seq_H3396_Human0.89562639
143IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89179126
144CTCF_20526341_ChIP-Seq_ESCs_Human0.88906886
145PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88898788
146SMAD3_21741376_ChIP-Seq_EPCs_Human0.88304205
147NCOR_22424771_ChIP-Seq_293T_Human0.87899566
148GATA3_21867929_ChIP-Seq_CD8_Mouse0.87609528
149CTCF_27219007_Chip-Seq_Bcells_Human0.87414596
150NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.87142051

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog9.08961536
2MP0003011_delayed_dark_adaptation8.60294917
3MP0005253_abnormal_eye_physiology6.16889391
4MP0006072_abnormal_retinal_apoptosis5.94699048
5MP0005410_abnormal_fertilization4.47735573
6MP0005195_abnormal_posterior_eye3.69450915
7MP0003950_abnormal_plasma_membrane3.58607612
8MP0002653_abnormal_ependyma_morphology3.46115054
9MP0001324_abnormal_eye_pigmentation3.31681886
10MP0003136_yellow_coat_color3.29196418
11MP0005391_vision/eye_phenotype3.15659455
12MP0002638_abnormal_pupillary_reflex2.61057325
13MP0002090_abnormal_vision2.58938254
14MP0001984_abnormal_olfaction2.57558662
15MP0002277_abnormal_respiratory_mucosa2.51555737
16MP0002229_neurodegeneration2.47687787
17MP0005423_abnormal_somatic_nervous2.41702873
18MP0003195_calcinosis2.33337912
19MP0003787_abnormal_imprinting2.30360519
20MP0002752_abnormal_somatic_nervous1.98773561
21MP0004142_abnormal_muscle_tone1.94804742
22* MP0003698_abnormal_male_reproductive1.91431957
23MP0003878_abnormal_ear_physiology1.79455270
24MP0005377_hearing/vestibular/ear_phenot1.79455270
25MP0001986_abnormal_taste_sensitivity1.74197188
26MP0001764_abnormal_homeostasis1.71517048
27MP0005174_abnormal_tail_pigmentation1.63666500
28MP0005394_taste/olfaction_phenotype1.61489343
29MP0005499_abnormal_olfactory_system1.61489343
30MP0004233_abnormal_muscle_weight1.58512634
31MP0000427_abnormal_hair_cycle1.58417160
32MP0002132_abnormal_respiratory_system1.58173329
33MP0001929_abnormal_gametogenesis1.58157814
34MP0008789_abnormal_olfactory_epithelium1.56066724
35MP0003121_genomic_imprinting1.55245975
36MP0003718_maternal_effect1.52364660
37MP0001502_abnormal_circadian_rhythm1.48450712
38MP0003724_increased_susceptibility_to1.48377965
39MP0002882_abnormal_neuron_morphology1.47612114
40MP0002938_white_spotting1.46726857
41MP0002736_abnormal_nociception_after1.44473256
42MP0000383_abnormal_hair_follicle1.38770288
43MP0008877_abnormal_DNA_methylation1.36651310
44MP0000372_irregular_coat_pigmentation1.35324829
45MP0005075_abnormal_melanosome_morpholog1.35055479
46MP0005248_abnormal_Harderian_gland1.33884758
47MP0006292_abnormal_olfactory_placode1.31369174
48MP0006276_abnormal_autonomic_nervous1.24911764
49MP0008875_abnormal_xenobiotic_pharmacok1.19463530
50MP0001485_abnormal_pinna_reflex1.17627766
51MP0002282_abnormal_trachea_morphology1.17378417
52MP0003122_maternal_imprinting1.17214298
53MP0001529_abnormal_vocalization1.16102035
54MP0004019_abnormal_vitamin_homeostasis1.13692012
55MP0003119_abnormal_digestive_system1.12911744
56MP0005084_abnormal_gallbladder_morpholo1.10229414
57MP0002735_abnormal_chemical_nociception1.09753622
58MP0000516_abnormal_urinary_system1.06491392
59MP0005367_renal/urinary_system_phenotyp1.06491392
60MP0002095_abnormal_skin_pigmentation1.03045435
61MP0002210_abnormal_sex_determination1.01610428
62MP0004885_abnormal_endolymph1.01403421
63MP0001346_abnormal_lacrimal_gland0.99662794
64* MP0002161_abnormal_fertility/fecundity0.98923534
65MP0002751_abnormal_autonomic_nervous0.98676153
66MP0009046_muscle_twitch0.97745622
67MP0001486_abnormal_startle_reflex0.95448846
68MP0003943_abnormal_hepatobiliary_system0.92171998
69MP0004270_analgesia0.90836147
70MP0005310_abnormal_salivary_gland0.88921076
71MP0005389_reproductive_system_phenotype0.86456344
72MP0000566_synostosis0.84943498
73MP0008872_abnormal_physiological_respon0.84591057
74MP0005395_other_phenotype0.84551338
75MP0001145_abnormal_male_reproductive0.83288990
76MP0002234_abnormal_pharynx_morphology0.83100937
77MP0003634_abnormal_glial_cell0.81865556
78MP0008057_abnormal_DNA_replication0.81274275
79MP0003890_abnormal_embryonic-extraembry0.79032131
80MP0005197_abnormal_uvea_morphology0.79024305
81MP0002876_abnormal_thyroid_physiology0.77539346
82MP0002272_abnormal_nervous_system0.76805520
83MP0002233_abnormal_nose_morphology0.76364094
84MP0000653_abnormal_sex_gland0.74069236
85MP0002127_abnormal_cardiovascular_syste0.73511857
86MP0005171_absent_coat_pigmentation0.73433453
87MP0002734_abnormal_mechanical_nocicepti0.67426692
88MP0003880_abnormal_central_pattern0.66638319
89MP0003635_abnormal_synaptic_transmissio0.65486693
90MP0002102_abnormal_ear_morphology0.65373448
91MP0005187_abnormal_penis_morphology0.65324995
92MP0001293_anophthalmia0.65137321
93MP0008004_abnormal_stomach_pH0.65129467
94MP0005623_abnormal_meninges_morphology0.65085991
95MP0001963_abnormal_hearing_physiology0.63893830
96MP0002064_seizures0.62949392
97MP0001286_abnormal_eye_development0.61863186
98MP0000631_abnormal_neuroendocrine_gland0.61424832
99MP0002572_abnormal_emotion/affect_behav0.61188871
100MP0010030_abnormal_orbit_morphology0.59686141
101MP0002332_abnormal_exercise_endurance0.59311556
102MP0002063_abnormal_learning/memory/cond0.59240885
103MP0002067_abnormal_sensory_capabilities0.58940824
104MP0002160_abnormal_reproductive_system0.57663579
105MP0004742_abnormal_vestibular_system0.54424959
106MP0001968_abnormal_touch/_nociception0.53457050
107MP0003646_muscle_fatigue0.53393057
108MP0004859_abnormal_synaptic_plasticity0.52157132
109MP0002152_abnormal_brain_morphology0.51594488
110MP0009745_abnormal_behavioral_response0.47358302
111MP0000778_abnormal_nervous_system0.47320629
112MP0005646_abnormal_pituitary_gland0.44349813
113MP0010386_abnormal_urinary_bladder0.43819055
114MP0004782_abnormal_surfactant_physiolog0.43012807
115MP0000026_abnormal_inner_ear0.41650843
116MP0002184_abnormal_innervation0.41492685
117MP0003861_abnormal_nervous_system0.39948348
118MP0002557_abnormal_social/conspecific_i0.39696543
119MP0002928_abnormal_bile_duct0.38125229
120MP0004811_abnormal_neuron_physiology0.36881098
121MP0008058_abnormal_DNA_repair0.36703975
122MP0002697_abnormal_eye_size0.35870461
123MP0000569_abnormal_digit_pigmentation0.35615582
124MP0005670_abnormal_white_adipose0.35394867
125MP0005076_abnormal_cell_differentiation0.33675063
126MP0005386_behavior/neurological_phenoty0.32291641
127MP0004924_abnormal_behavior0.32291641
128MP0004085_abnormal_heartbeat0.30867863
129MP0002066_abnormal_motor_capabilities/c0.29230546
130MP0004133_heterotaxia0.28616299
131MP0005376_homeostasis/metabolism_phenot0.28354825
132MP0003879_abnormal_hair_cell0.26561055
133MP0008569_lethality_at_weaning0.26255560
134MP0002092_abnormal_eye_morphology0.25647900
135MP0001440_abnormal_grooming_behavior0.24740430
136MP0000955_abnormal_spinal_cord0.20824315
137MP0004145_abnormal_muscle_electrophysio0.19487606
138MP0003633_abnormal_nervous_system0.19314367
139MP0008995_early_reproductive_senescence0.19302877
140MP0005620_abnormal_muscle_contractility0.18894925
141MP0002108_abnormal_muscle_morphology0.18571812
142MP0001915_intracranial_hemorrhage0.18254088
143MP0004043_abnormal_pH_regulation0.17878386

Predicted human phenotypes

RankGene SetZ-score
1Bony spicule pigmentary retinopathy (HP:0007737)9.93998361
2Absent rod-and cone-mediated responses on ERG (HP:0007688)8.78438727
3Dyschromatopsia (HP:0007641)8.63235938
4Abnormal rod and cone electroretinograms (HP:0008323)8.58269352
5Central scotoma (HP:0000603)7.63679583
6Abnormality of macular pigmentation (HP:0008002)7.34372698
7Pigmentary retinal degeneration (HP:0001146)7.31585111
8Pendular nystagmus (HP:0012043)7.11164646
9Chorioretinal atrophy (HP:0000533)7.02916185
10Attenuation of retinal blood vessels (HP:0007843)6.56092946
11Scotoma (HP:0000575)6.51747776
12Abolished electroretinogram (ERG) (HP:0000550)6.15919028
13Decreased central vision (HP:0007663)6.13006066
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.33879722
15* Photophobia (HP:0000613)4.95477864
16* Type II diabetes mellitus (HP:0005978)4.85045053
17Dynein arm defect of respiratory motile cilia (HP:0012255)4.82803019
18Absent/shortened dynein arms (HP:0200106)4.82803019
19Severe visual impairment (HP:0001141)4.76772321
20Cone-rod dystrophy (HP:0000548)4.59798019
21Macular degeneration (HP:0000608)4.58593575
22Vitreoretinal degeneration (HP:0000655)4.39799555
23Posterior subcapsular cataract (HP:0007787)4.30787493
24Abnormal respiratory motile cilium physiology (HP:0012261)4.24380143
25Keratoconus (HP:0000563)4.17318692
26Increased corneal curvature (HP:0100692)4.17318692
27Retinitis pigmentosa (HP:0000510)4.17058745
28Choroideremia (HP:0001139)4.17055225
29Constricted visual fields (HP:0001133)4.15780142
30Abnormal respiratory epithelium morphology (HP:0012253)3.74112658
31Abnormal respiratory motile cilium morphology (HP:0005938)3.74112658
32Abnormal ciliary motility (HP:0012262)3.67721594
33Rhinitis (HP:0012384)3.42042047
34Gait imbalance (HP:0002141)3.24984059
35Congenital primary aphakia (HP:0007707)3.22132626
36Medial flaring of the eyebrow (HP:0010747)3.20416543
37Decreased electroretinogram (ERG) amplitude (HP:0000654)3.00698770
38Chronic bronchitis (HP:0004469)2.89354619
39Nephrogenic diabetes insipidus (HP:0009806)2.89319280
40Subcapsular cataract (HP:0000523)2.86790050
41Occipital encephalocele (HP:0002085)2.86656272
42Abnormality of the renal cortex (HP:0011035)2.60061926
43Progressive visual loss (HP:0000529)2.54348227
44Pancreatic fibrosis (HP:0100732)2.52317393
45Septo-optic dysplasia (HP:0100842)2.52035306
46Poor coordination (HP:0002370)2.49385818
47Retinal atrophy (HP:0001105)2.46614359
48Tubular atrophy (HP:0000092)2.46560593
49True hermaphroditism (HP:0010459)2.42923765
50Nephronophthisis (HP:0000090)2.41329681
51Chronic sinusitis (HP:0011109)2.37660802
52Intestinal atresia (HP:0011100)2.29981707
53Vaginal atresia (HP:0000148)2.28889364
54Genital tract atresia (HP:0001827)2.28706508
55Oligodactyly (hands) (HP:0001180)2.19620177
56Recurrent sinusitis (HP:0011108)2.13906227
57* Wide nasal bridge (HP:0000431)2.13160460
58Male pseudohermaphroditism (HP:0000037)2.10924679
59Abnormality of midbrain morphology (HP:0002418)2.09374855
60Molar tooth sign on MRI (HP:0002419)2.09374855
61* Optic disc pallor (HP:0000543)2.07892578
62Preaxial hand polydactyly (HP:0001177)2.07757048
63Progressive inability to walk (HP:0002505)2.07164827
64Supernumerary spleens (HP:0009799)2.05495251
65Optic nerve hypoplasia (HP:0000609)2.02986408
66Congenital stationary night blindness (HP:0007642)11.8413347
67Aplasia/Hypoplasia of the lens (HP:0008063)1.99543106
68Tubulointerstitial abnormality (HP:0001969)1.98592628
69Abnormal drinking behavior (HP:0030082)1.97233751
70Polydipsia (HP:0001959)1.97233751
71Infertility (HP:0000789)1.96615954
72Congenital sensorineural hearing impairment (HP:0008527)1.96427775
73Retrobulbar optic neuritis (HP:0100654)1.95235850
74Optic neuritis (HP:0100653)1.95235850
75Aplasia/Hypoplasia of the tongue (HP:0010295)1.94694401
76Hyperventilation (HP:0002883)1.90442460
77Abnormal biliary tract physiology (HP:0012439)1.89769514
78Bile duct proliferation (HP:0001408)1.89769514
79Narrow forehead (HP:0000341)1.86951036
80Abnormality of the renal medulla (HP:0100957)1.85567729
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84962649
82Cystic liver disease (HP:0006706)1.84948747
83Bronchiectasis (HP:0002110)1.84489873
84Nasal polyposis (HP:0100582)1.83007028
85Pancreatic cysts (HP:0001737)1.81703763
86Abnormality of the labia minora (HP:0012880)1.80740924
87Anophthalmia (HP:0000528)1.80407947
88Asplenia (HP:0001746)1.79422743
89Aplasia/Hypoplasia of the spleen (HP:0010451)1.77953178
90Chronic otitis media (HP:0000389)1.77577883
91Hip dysplasia (HP:0001385)1.76442758
92Stomach cancer (HP:0012126)1.68837007
93Absent speech (HP:0001344)1.67053161
94Polyuria (HP:0000103)1.65333731
95Median cleft lip (HP:0000161)1.62739370
96Hypochromic microcytic anemia (HP:0004840)1.61838638
97Type II lissencephaly (HP:0007260)1.61032096
98Gastrointestinal atresia (HP:0002589)1.60523496
99Recurrent otitis media (HP:0000403)1.59761242
100Prominent nasal bridge (HP:0000426)1.59319207
101Aganglionic megacolon (HP:0002251)1.59230313
102Nephropathy (HP:0000112)1.58555291
103Highly arched eyebrow (HP:0002553)1.58535004
104Congenital hepatic fibrosis (HP:0002612)1.57629415
105Inability to walk (HP:0002540)1.57385613
106Stomatitis (HP:0010280)1.57139569
107Bifid tongue (HP:0010297)1.56321659
108Postaxial foot polydactyly (HP:0001830)1.54041655
109Astigmatism (HP:0000483)1.50660372
110Postaxial hand polydactyly (HP:0001162)1.49836058
111Sclerocornea (HP:0000647)1.44624005
112Polar cataract (HP:0010696)1.44531568
113Bronchitis (HP:0012387)1.42685859
114Abnormality of the nasal mucosa (HP:0000433)1.42285226
115Horizontal nystagmus (HP:0000666)1.39906748
116* Optic atrophy (HP:0000648)1.39798179
117Specific learning disability (HP:0001328)1.37117119
118Cerebellar dysplasia (HP:0007033)1.36495191
119Tubulointerstitial nephritis (HP:0001970)1.36229548
120Chronic hepatic failure (HP:0100626)1.34865643
121Broad foot (HP:0001769)1.33071219
122Progressive cerebellar ataxia (HP:0002073)1.30648621
123Dysdiadochokinesis (HP:0002075)1.30290489
124Epileptic encephalopathy (HP:0200134)1.30034509
125Severe Myopia (HP:0011003)1.28343469
126Left ventricular hypertrophy (HP:0001712)1.23548718
127Anencephaly (HP:0002323)1.21885159
128Decreased testicular size (HP:0008734)1.21451953
129Heterotopia (HP:0002282)1.19725159
130Oculomotor apraxia (HP:0000657)1.16456791
131Febrile seizures (HP:0002373)1.13063548
132Abdominal situs inversus (HP:0003363)1.12556736
133Abnormality of abdominal situs (HP:0011620)1.12556736
134Asthma (HP:0002099)1.12141261
135Male infertility (HP:0003251)1.09243701
136Genetic anticipation (HP:0003743)1.07889064
137Furrowed tongue (HP:0000221)1.07089779
138Abnormality of the lower motor neuron (HP:0002366)1.05836641
139Truncal ataxia (HP:0002078)1.03484083
140Gaze-evoked nystagmus (HP:0000640)1.03421288
141Hypodontia (HP:0000668)1.02761211
142Chorioretinal coloboma (HP:0000567)1.02343634

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK17.33838776
2PBK5.97706173
3FRK4.79306311
4PDK44.15059118
5PDK34.15059118
6PRKD33.43574115
7BMPR1B3.42876592
8ICK3.32049433
9PNCK3.31726742
10WNK33.28832664
11PDK23.19834333
12TNIK3.08765531
13ACVR1B2.79502461
14TESK12.28339533
15MAP4K22.28327226
16CAMK1G2.28311491
17PINK12.22624349
18NUAK12.10493001
19CASK2.08735398
20TRIM282.03038027
21MAPK131.91769783
22IRAK21.89019901
23STK381.74952724
24BCR1.52247296
25TXK1.50731441
26PLK41.50320390
27FGFR21.41842154
28NLK1.40390089
29NEK21.38513727
30CAMK1D1.37005476
31EPHA31.36556136
32STK161.35980823
33TIE11.34435241
34MAPK151.34074375
35ZAK1.32138871
36WNK41.26443031
37TGFBR11.25544593
38ADRBK21.22771479
39PTK2B1.14786087
40BRSK21.12985294
41CDK121.12335895
42MAP3K41.11281353
43STK391.08789031
44WNK11.08688115
45SIK21.07194939
46MAPK71.06878836
47AKT31.06157772
48DYRK1B1.05566339
49PAK61.05507488
50CCNB11.01587670
51ADRBK11.01556100
52IRAK40.99872712
53SGK4940.99573367
54SGK2230.99573367
55RIPK40.98856018
56BRD40.97160427
57PAK30.96875280
58MARK10.96747212
59CDK30.93794646
60WEE10.91948529
61MAP3K100.91185042
62OXSR10.91073362
63MAPK120.88664940
64DYRK20.86061172
65GRK70.84456486
66ERBB30.82541758
67SGK20.82472007
68MKNK20.79082229
69NTRK20.78906474
70TLK10.78770364
71VRK10.77833610
72DYRK1A0.76472864
73PRKCZ0.75364877
74MARK30.73468353
75PRKCQ0.72415931
76STK110.71905232
77TTK0.70517809
78PRKCE0.69386518
79CSNK1D0.68824865
80MST40.67268086
81STK240.66441754
82PRKAA10.63856188
83SGK30.62660749
84PRKCG0.62197668
85EPHB10.62100866
86CAMK2D0.61872550
87CSK0.60674182
88YES10.59030151
89INSRR0.58374206
90ERBB40.58284592
91NEK60.57995459
92BLK0.56437392
93CHEK20.56222904
94GRK60.55173083
95NTRK30.55020941
96ERBB20.53270906
97PRKCB0.51200789
98HIPK20.51002863
99PDK10.50537756
100PRPF4B0.50515321
101PLK20.50011116
102MATK0.49495724
103BCKDK0.49478937
104STK38L0.46653773
105IRAK10.46638303
106TEC0.45615827
107CHEK10.45160602
108EPHA40.45074687
109MAP2K70.44198393
110CAMKK10.44064020
111TGFBR20.43729588
112RPS6KA40.43054969
113GSK3B0.42911157
114RPS6KA30.41690783
115LATS10.41595872
116LYN0.41497486
117PRKACG0.41174005
118PRKG10.41059666
119ATM0.40544875
120PIK3CG0.40499853
121CAMK10.40080355
122CAMK2A0.39970923
123IKBKE0.39441116
124PHKG10.39361587
125PHKG20.39361587
126MINK10.37941907
127FER0.37820814
128DYRK30.37368767
129PKN10.36330636
130KIT0.35928588
131PRKCH0.35016124
132MAPK100.34285389
133PLK30.34280848
134PRKCI0.34130668
135CHUK0.34073872
136PRKAA20.33774037
137CDC70.32893256
138CDK50.32484555
139CDK10.31297067
140PLK10.30812454
141JAK20.30074315
142STK30.29852081
143MAP2K40.29791983
144PRKDC0.29753376
145MAPK140.29562104
146CDK90.29441382
147SGK10.29132086
148FES0.27926996
149CAMK40.27790454
150TNK20.27765558
151DAPK20.27279866
152MTOR0.26955138
153GRK50.26889898
154MARK20.24556310
155PRKACA0.21885424
156TAOK30.21831424
157MAPK80.21469947
158PRKD20.21418404
159MAPK90.21142684
160ATR0.21059027
161RPS6KB10.20524892

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.53617640
2Olfactory transduction_Homo sapiens_hsa047402.18335117
3Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.00242978
4Phototransduction_Homo sapiens_hsa0474414.9226750
5Butanoate metabolism_Homo sapiens_hsa006501.99795643
6Homologous recombination_Homo sapiens_hsa034401.96596482
7Synaptic vesicle cycle_Homo sapiens_hsa047211.89943670
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.59243471
9Nitrogen metabolism_Homo sapiens_hsa009101.57271636
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56741614
11Regulation of autophagy_Homo sapiens_hsa041401.53382474
12Propanoate metabolism_Homo sapiens_hsa006401.41935137
13GABAergic synapse_Homo sapiens_hsa047271.29795700
14Chemical carcinogenesis_Homo sapiens_hsa052041.20098384
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18891657
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.14901489
17Peroxisome_Homo sapiens_hsa041461.14834610
18Morphine addiction_Homo sapiens_hsa050321.09974019
19Circadian entrainment_Homo sapiens_hsa047131.08456445
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07987849
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06769557
22Non-homologous end-joining_Homo sapiens_hsa034501.04327156
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03849429
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02481240
25Histidine metabolism_Homo sapiens_hsa003401.02059383
26Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00131241
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99396230
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97679862
29Primary bile acid biosynthesis_Homo sapiens_hsa001200.96024288
30Glutamatergic synapse_Homo sapiens_hsa047240.95720478
31Circadian rhythm_Homo sapiens_hsa047100.94433114
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93596625
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93294042
34Basal cell carcinoma_Homo sapiens_hsa052170.93066260
35Dopaminergic synapse_Homo sapiens_hsa047280.91743988
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90800682
37Cholinergic synapse_Homo sapiens_hsa047250.90703319
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87293606
39Insulin secretion_Homo sapiens_hsa049110.85222083
40Oxidative phosphorylation_Homo sapiens_hsa001900.84223083
41Selenocompound metabolism_Homo sapiens_hsa004500.84040641
42RNA polymerase_Homo sapiens_hsa030200.81201012
43Nucleotide excision repair_Homo sapiens_hsa034200.80795040
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80037280
45Nicotine addiction_Homo sapiens_hsa050330.79655904
46beta-Alanine metabolism_Homo sapiens_hsa004100.78133857
47Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77397933
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76208383
49TGF-beta signaling pathway_Homo sapiens_hsa043500.74883813
50Glucagon signaling pathway_Homo sapiens_hsa049220.74004018
51Purine metabolism_Homo sapiens_hsa002300.73944682
52Parkinsons disease_Homo sapiens_hsa050120.73719945
53Protein export_Homo sapiens_hsa030600.73655769
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72728664
55Retinol metabolism_Homo sapiens_hsa008300.72708115
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72000825
57Arachidonic acid metabolism_Homo sapiens_hsa005900.71103438
58Fructose and mannose metabolism_Homo sapiens_hsa000510.69853376
59Serotonergic synapse_Homo sapiens_hsa047260.69441832
60Tryptophan metabolism_Homo sapiens_hsa003800.69007161
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68939661
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68780389
63Renin secretion_Homo sapiens_hsa049240.66444240
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.66273652
65Glycerolipid metabolism_Homo sapiens_hsa005610.65975279
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.65602265
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65563565
68ABC transporters_Homo sapiens_hsa020100.65179620
69Cardiac muscle contraction_Homo sapiens_hsa042600.60938618
70Mismatch repair_Homo sapiens_hsa034300.60893399
71Amphetamine addiction_Homo sapiens_hsa050310.60882086
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60529717
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.58254723
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57974037
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57704779
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57696728
77Steroid biosynthesis_Homo sapiens_hsa001000.57066385
78Fatty acid biosynthesis_Homo sapiens_hsa000610.55410169
79cAMP signaling pathway_Homo sapiens_hsa040240.53960958
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53828577
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52543203
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52314289
83Salivary secretion_Homo sapiens_hsa049700.52294558
84Pyruvate metabolism_Homo sapiens_hsa006200.52231513
85Oxytocin signaling pathway_Homo sapiens_hsa049210.52099685
86Staphylococcus aureus infection_Homo sapiens_hsa051500.51746354
87Taste transduction_Homo sapiens_hsa047420.51444283
88Long-term potentiation_Homo sapiens_hsa047200.51297316
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51260344
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50357874
91Gastric acid secretion_Homo sapiens_hsa049710.49847002
92Fatty acid degradation_Homo sapiens_hsa000710.48640037
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47727058
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46575495
95Oocyte meiosis_Homo sapiens_hsa041140.46128253
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45403261
97Inositol phosphate metabolism_Homo sapiens_hsa005620.45005951
98Collecting duct acid secretion_Homo sapiens_hsa049660.43918714
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43682947
100mRNA surveillance pathway_Homo sapiens_hsa030150.42803415
101Mineral absorption_Homo sapiens_hsa049780.42779469
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42740661
103Hippo signaling pathway_Homo sapiens_hsa043900.42113405
104Calcium signaling pathway_Homo sapiens_hsa040200.40867697
105FoxO signaling pathway_Homo sapiens_hsa040680.40293088
106Axon guidance_Homo sapiens_hsa043600.39373880
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39362751
108Basal transcription factors_Homo sapiens_hsa030220.39125665
109Linoleic acid metabolism_Homo sapiens_hsa005910.38711373
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.38291784
111Dorso-ventral axis formation_Homo sapiens_hsa043200.38136672
112Measles_Homo sapiens_hsa051620.37407434
113Cocaine addiction_Homo sapiens_hsa050300.37031692
114Chemokine signaling pathway_Homo sapiens_hsa040620.36987556
115Graft-versus-host disease_Homo sapiens_hsa053320.35965482
116Vitamin B6 metabolism_Homo sapiens_hsa007500.32666045
117Alcoholism_Homo sapiens_hsa050340.31731471
118Type II diabetes mellitus_Homo sapiens_hsa049300.30164458
119HIF-1 signaling pathway_Homo sapiens_hsa040660.27880342
120mTOR signaling pathway_Homo sapiens_hsa041500.27553872
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26279062
122Dilated cardiomyopathy_Homo sapiens_hsa054140.25367141
123Ether lipid metabolism_Homo sapiens_hsa005650.24885281
124Thyroid hormone synthesis_Homo sapiens_hsa049180.24744279
125Bile secretion_Homo sapiens_hsa049760.24390144
126Caffeine metabolism_Homo sapiens_hsa002320.24038303
127AMPK signaling pathway_Homo sapiens_hsa041520.23483513
128Pancreatic secretion_Homo sapiens_hsa049720.21219177
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.20824886
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.20188907
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18437235
132Pentose phosphate pathway_Homo sapiens_hsa000300.17629421
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.16681197
134Estrogen signaling pathway_Homo sapiens_hsa049150.16596004
135Huntingtons disease_Homo sapiens_hsa050160.16540345
136Wnt signaling pathway_Homo sapiens_hsa043100.15169125
137MAPK signaling pathway_Homo sapiens_hsa040100.14973894
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.14850528
139Hedgehog signaling pathway_Homo sapiens_hsa043400.14699096
140Biosynthesis of amino acids_Homo sapiens_hsa012300.14353065
141Ras signaling pathway_Homo sapiens_hsa040140.13358522
142Ovarian steroidogenesis_Homo sapiens_hsa049130.13046817
143GnRH signaling pathway_Homo sapiens_hsa049120.12653140
144Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11596771
145RNA degradation_Homo sapiens_hsa030180.11573596
146Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.11537436
147Fanconi anemia pathway_Homo sapiens_hsa034600.11349770
148Endocytosis_Homo sapiens_hsa041440.11016276
149Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.10727702
150Vibrio cholerae infection_Homo sapiens_hsa051100.09991435
151SNARE interactions in vesicular transport_Homo sapiens_hsa041300.09953269
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.09761175
153Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.09483812
154Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.09368154
155Cysteine and methionine metabolism_Homo sapiens_hsa002700.09237912
156PPAR signaling pathway_Homo sapiens_hsa033200.08817509
157Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.08275436

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