MAL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.91119787
2* ensheathment of neurons (GO:0007272)6.88074381
3* axon ensheathment (GO:0008366)6.88074381
4* myelination (GO:0042552)6.75529306
5long-chain fatty acid biosynthetic process (GO:0042759)6.29460491
6keratinization (GO:0031424)6.12412603
7myelin maintenance (GO:0043217)5.87607195
8negative T cell selection (GO:0043383)5.52336523
9peptide cross-linking (GO:0018149)5.26317663
10positive T cell selection (GO:0043368)5.21438766
11negative thymic T cell selection (GO:0045060)5.11567421
12negative regulation of neurotransmitter secretion (GO:0046929)5.11408483
13establishment of mitochondrion localization (GO:0051654)5.08757427
14oligodendrocyte differentiation (GO:0048709)4.99510080
15positive thymic T cell selection (GO:0045059)4.95384962
16creatine metabolic process (GO:0006600)4.93857703
17positive regulation of gamma-delta T cell activation (GO:0046645)4.91407565
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.91288934
19negative regulation of neurotransmitter transport (GO:0051589)4.87169077
20thymic T cell selection (GO:0045061)4.86043428
21cholesterol biosynthetic process (GO:0006695)4.68826869
22T cell selection (GO:0045058)4.51801058
23negative regulation of protein localization to cell surface (GO:2000009)4.45547332
24astrocyte development (GO:0014002)4.40114684
25positive regulation of oligodendrocyte differentiation (GO:0048714)4.38386203
26negative regulation of cell killing (GO:0031342)4.35381971
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.35381971
28glutamate secretion (GO:0014047)4.31456039
29presynaptic membrane organization (GO:0097090)4.25484338
30regulation of gamma-delta T cell differentiation (GO:0045586)4.23811834
31regulation of collateral sprouting (GO:0048670)4.23255706
32glycerophospholipid catabolic process (GO:0046475)4.17255938
33synaptic vesicle exocytosis (GO:0016079)4.16485891
34response to interleukin-15 (GO:0070672)4.16263264
35response to methylmercury (GO:0051597)4.12801284
36eye photoreceptor cell differentiation (GO:0001754)4.11740380
37photoreceptor cell differentiation (GO:0046530)4.11740380
38sterol biosynthetic process (GO:0016126)4.10162753
39synaptic vesicle maturation (GO:0016188)4.08520291
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.07461731
41leukocyte aggregation (GO:0070486)4.00720338
42cellular response to interleukin-15 (GO:0071350)3.99625716
43signal complex assembly (GO:0007172)3.97805142
44positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.95728494
45synaptic vesicle docking involved in exocytosis (GO:0016081)3.91664262
46long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.90710009
47regulation of synaptic vesicle exocytosis (GO:2000300)3.86983052
48presynaptic membrane assembly (GO:0097105)3.82238584
49regulation of gamma-delta T cell activation (GO:0046643)3.78845217
50T cell migration (GO:0072678)3.77169609
51isoprenoid biosynthetic process (GO:0008299)3.76612993
52substantia nigra development (GO:0021762)3.74394676
53antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.73690343
54import into cell (GO:0098657)3.73027142
55adhesion of symbiont to host cell (GO:0044650)3.68596139
56virion attachment to host cell (GO:0019062)3.68596139
57long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.67610947
58regulation of ARF protein signal transduction (GO:0032012)3.67318355
59peptidyl-tyrosine autophosphorylation (GO:0038083)3.63426195
60keratinocyte differentiation (GO:0030216)3.60635490
61response to lipoprotein particle (GO:0055094)3.60215047
62regulation of B cell receptor signaling pathway (GO:0050855)3.58846935
63regulation of lipoprotein metabolic process (GO:0050746)3.56277495
64response to redox state (GO:0051775)3.55083926
65L-amino acid import (GO:0043092)3.54847682
66GPI anchor biosynthetic process (GO:0006506)3.54422593
67regulation of T cell tolerance induction (GO:0002664)3.53172057
68protein palmitoylation (GO:0018345)3.50716452
69positive regulation of Rap GTPase activity (GO:0032854)3.50451852
70cellular potassium ion homeostasis (GO:0030007)3.47769541
71GPI anchor metabolic process (GO:0006505)3.45141664
72amyloid precursor protein metabolic process (GO:0042982)3.45118891
73antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.42839723
74axon development (GO:0061564)3.39929670
75fatty-acyl-CoA biosynthetic process (GO:0046949)3.39025784
76membrane tubulation (GO:0097320)3.37072572
77sodium ion export (GO:0071436)3.36840470
78regulation of synaptic vesicle transport (GO:1902803)3.33835714
79positive regulation of granulocyte differentiation (GO:0030854)3.33674336
80antigen processing and presentation of endogenous antigen (GO:0019883)3.33278450
81myelination in peripheral nervous system (GO:0022011)3.31591243
82peripheral nervous system axon ensheathment (GO:0032292)3.31591243
83fatty-acyl-CoA metabolic process (GO:0035337)3.27516039
84negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.26285096
85regulation of regulatory T cell differentiation (GO:0045589)3.25976849
86regulation of interleukin-2 biosynthetic process (GO:0045076)3.19822834
87negative regulation of JUN kinase activity (GO:0043508)3.18998133
88glycosylceramide metabolic process (GO:0006677)3.18976104
89positive regulation of glial cell differentiation (GO:0045687)3.16436842
90negative regulation of T cell mediated immunity (GO:0002710)3.15250412
91positive regulation of tolerance induction (GO:0002645)3.12300945
92iron coordination entity transport (GO:1901678)3.11781915
93heme transport (GO:0015886)3.11024879
94adult walking behavior (GO:0007628)3.10005229
95regulation of isotype switching to IgG isotypes (GO:0048302)3.08507700
96neuron cell-cell adhesion (GO:0007158)3.05872143
97* asymmetric protein localization (GO:0008105)3.05717715
98positive regulation of interleukin-4 production (GO:0032753)3.04375779
99T cell receptor signaling pathway (GO:0050852)3.03736831
100very long-chain fatty acid metabolic process (GO:0000038)3.03628790
101regulation of Rap GTPase activity (GO:0032317)3.03386742
102regulation of interleukin-4 production (GO:0032673)3.00140816
103preassembly of GPI anchor in ER membrane (GO:0016254)3.00001599
104epidermal cell differentiation (GO:0009913)2.98250734
105magnesium ion transport (GO:0015693)2.97962519
106neuron remodeling (GO:0016322)2.97782759
107positive regulation of cellular amine metabolic process (GO:0033240)2.96948197
108activated T cell proliferation (GO:0050798)2.95682241
109peptidyl-cysteine modification (GO:0018198)2.95150912
110tolerance induction (GO:0002507)2.94759523
111positive regulation of gliogenesis (GO:0014015)2.92866611
112limb bud formation (GO:0060174)2.92108493
113locomotory exploration behavior (GO:0035641)2.90990761
114neurotransmitter secretion (GO:0007269)2.90422077
115negative regulation of axonogenesis (GO:0050771)2.89077864
116negative regulation of leukocyte mediated immunity (GO:0002704)2.88673429
117negative regulation of acute inflammatory response (GO:0002674)2.88282086
118regulation of defense response to virus by virus (GO:0050690)2.87458110
119glial cell development (GO:0021782)2.86466691
120positive regulation of calcium-mediated signaling (GO:0050850)2.85674865
121nucleotide transmembrane transport (GO:1901679)2.85350714
122negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.84244165
123negative regulation of execution phase of apoptosis (GO:1900118)2.83785310
124leukocyte migration involved in inflammatory response (GO:0002523)2.82984843
125cerebellar Purkinje cell differentiation (GO:0021702)2.82969436
126T cell homeostasis (GO:0043029)2.82641298
127negative regulation of lymphocyte mediated immunity (GO:0002707)2.82502775
128cerebral cortex radially oriented cell migration (GO:0021799)2.82163809
129positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.81825527
130regulation of alpha-beta T cell proliferation (GO:0046640)2.81525939
131cytidine metabolic process (GO:0046087)2.81061337
132cytidine catabolic process (GO:0006216)2.81061337
133cytidine deamination (GO:0009972)2.81061337
134regulation of tolerance induction (GO:0002643)2.80360481
135negative regulation of bone mineralization (GO:0030502)2.80000781
136enteric nervous system development (GO:0048484)2.78492493
137antigen receptor-mediated signaling pathway (GO:0050851)2.77120000
138mast cell activation (GO:0045576)2.76003827
139negative regulation of macroautophagy (GO:0016242)2.75368367
140potassium ion import (GO:0010107)2.75005917
141regulation of dopamine metabolic process (GO:0042053)2.74479492
142regulation of catecholamine metabolic process (GO:0042069)2.74479492
143lymphocyte migration (GO:0072676)2.73903564
144regulation of platelet aggregation (GO:0090330)2.73781546
145nerve growth factor signaling pathway (GO:0038180)2.72907658
146regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.72691779
147amyloid precursor protein catabolic process (GO:0042987)2.71309162
148response to lead ion (GO:0010288)2.70583569
149protein neddylation (GO:0045116)2.70554805
150acyl-CoA biosynthetic process (GO:0071616)2.69555573
151thioester biosynthetic process (GO:0035384)2.69555573
152microtubule polymerization or depolymerization (GO:0031109)2.68985270
153regulation of natural killer cell mediated immunity (GO:0002715)2.68591281
154regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.68591281
155negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.68266399
156positive regulation of action potential (GO:0045760)2.68246111
157adhesion of symbiont to host (GO:0044406)2.67673850
158pyrimidine ribonucleoside catabolic process (GO:0046133)2.67503533
159negative regulation of inclusion body assembly (GO:0090084)2.65012310
160Leydig cell differentiation (GO:0033327)2.64871851
161mucosal-associated lymphoid tissue development (GO:0048537)2.64610651
162Peyers patch development (GO:0048541)2.64610651
163organ growth (GO:0035265)2.64049508
164cerebellar granule cell differentiation (GO:0021707)2.63572572
165neuronal action potential propagation (GO:0019227)2.61656879
166neuronal ion channel clustering (GO:0045161)2.60366769
167long-term synaptic potentiation (GO:0060291)2.59065496
168positive regulation of alpha-beta T cell proliferation (GO:0046641)2.57019318
169glial cell differentiation (GO:0010001)2.56680867
170potassium ion homeostasis (GO:0055075)2.56569047
171negative regulation of interleukin-17 production (GO:0032700)2.56098742
172regulation of short-term neuronal synaptic plasticity (GO:0048172)2.55967877
173transmission of nerve impulse (GO:0019226)2.55897001
174cellular response to epinephrine stimulus (GO:0071872)2.54187145
175amino acid import (GO:0043090)2.53965524
176dopamine biosynthetic process (GO:0042416)2.53608460
177regulation of somitogenesis (GO:0014807)2.53477662
178neural nucleus development (GO:0048857)2.53193107
179alpha-beta T cell differentiation (GO:0046632)2.53024029
180detection of bacterium (GO:0016045)2.52648769
181cyclic nucleotide catabolic process (GO:0009214)2.52345018
182establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.52138146
183mitochondrion transport along microtubule (GO:0047497)2.52138146
184peripheral nervous system development (GO:0007422)2.52129039
185membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.51464662
186positive regulation of natural killer cell mediated immunity (GO:0002717)2.50094843
187negative regulation of erythrocyte differentiation (GO:0045647)2.49513479
188regulation of neuronal synaptic plasticity (GO:0048168)2.48881222
189B cell receptor signaling pathway (GO:0050853)2.48578653
190negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.44037887
191mast cell degranulation (GO:0043303)2.40568282
192mast cell activation involved in immune response (GO:0002279)2.40568282
193central nervous system myelination (GO:0022010)12.2915958
194axon ensheathment in central nervous system (GO:0032291)12.2915958

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.58229006
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.28086331
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.57430043
4RUNX_20019798_ChIP-Seq_JUKART_Human3.34285295
5GBX2_23144817_ChIP-Seq_PC3_Human3.24255822
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.89908406
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.70643582
8SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.65378085
9TAF15_26573619_Chip-Seq_HEK293_Human2.54089337
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.48271709
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32885549
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.32855334
13* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.27734430
14* KDM2B_26808549_Chip-Seq_DND41_Human2.27642180
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26888237
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.20169175
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.18200163
18EZH2_22144423_ChIP-Seq_EOC_Human2.09136162
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.06817323
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.05794857
21* MYB_26560356_Chip-Seq_TH2_Human2.05327948
22* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.05309558
23TCF7_22412390_ChIP-Seq_EML_Mouse2.03445169
24OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.03413926
25* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01782544
26UTX_26944678_Chip-Seq_JUKART_Human2.00403434
27EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00218335
28RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00218335
29MAF_26560356_Chip-Seq_TH1_Human1.98703632
30* MAF_26560356_Chip-Seq_TH2_Human1.96176766
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.96096182
32* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95144176
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.94789514
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.92334775
35E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.91330438
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90525818
37* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86858286
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.85088811
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84727253
40LXR_22292898_ChIP-Seq_THP-1_Human1.81810807
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.80863326
42KDM2B_26808549_Chip-Seq_JURKAT_Human1.80758284
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.79940492
44* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79889842
45MYC_22102868_ChIP-Seq_BL_Human1.77124422
46* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74294467
47* EZH2_27294783_Chip-Seq_ESCs_Mouse1.74284497
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72927110
49ER_23166858_ChIP-Seq_MCF-7_Human1.71319751
50MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.69476908
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.67818794
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67607997
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65133668
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64931237
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.61561588
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61389638
57VDR_21846776_ChIP-Seq_THP-1_Human1.59300144
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.58436843
59* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58224803
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.57623384
61KDM2B_26808549_Chip-Seq_K562_Human1.57466714
62MYB_26560356_Chip-Seq_TH1_Human1.57397349
63VDR_22108803_ChIP-Seq_LS180_Human1.56036182
64STAT4_19710469_ChIP-ChIP_TH1__Mouse1.55826762
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55251494
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54216526
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54072312
68* GATA3_27048872_Chip-Seq_THYMUS_Human1.54034992
69STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.53460451
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52402883
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.49309569
72SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48992862
73RUNX1_22412390_ChIP-Seq_EML_Mouse1.46730710
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45088265
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44910833
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44902959
77SCL_19346495_ChIP-Seq_HPC-7_Human1.44249740
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.44004691
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43335223
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.42971537
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40176461
82AR_21572438_ChIP-Seq_LNCaP_Human1.40014648
83SPI1_23127762_ChIP-Seq_K562_Human1.39734536
84DROSHA_22980978_ChIP-Seq_HELA_Human1.38588316
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35745129
86WT1_19549856_ChIP-ChIP_CCG9911_Human1.34942752
87SMC4_20622854_ChIP-Seq_HELA_Human1.33277498
88VDR_24763502_ChIP-Seq_THP-1_Human1.33053014
89* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31815491
90CTCF_27219007_Chip-Seq_Bcells_Human1.30542045
91* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30016167
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27951309
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.27848388
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26061761
95* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25579044
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24252672
97SA1_27219007_Chip-Seq_ERYTHROID_Human1.21286153
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20081301
99TRIM28_21343339_ChIP-Seq_HEK293_Human1.19993700
100GATA1_19941827_ChIP-Seq_MEL_Mouse1.19981502
101P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19980598
102RARB_27405468_Chip-Seq_BRAIN_Mouse1.18982375
103P68_20966046_ChIP-Seq_HELA_Human1.17876941
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17505559
105NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17505559
106P300_19829295_ChIP-Seq_ESCs_Human1.17444110
107REST_18959480_ChIP-ChIP_MESCs_Mouse1.16055980
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16023867
109CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15046828
110RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14910910
111TAL1_26923725_Chip-Seq_HPCs_Mouse1.14666921
112RACK7_27058665_Chip-Seq_MCF-7_Human1.14486604
113CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14094315
114MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13764787
115FUS_26573619_Chip-Seq_HEK293_Human1.13758256
116EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13608990
117LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13322477
118ELK3_25401928_ChIP-Seq_HUVEC_Human1.13234922
119ZFP281_27345836_Chip-Seq_ESCs_Mouse1.13179577
120GATA1_26923725_Chip-Seq_HPCs_Mouse1.12803440
121EOMES_21245162_ChIP-Seq_HESCs_Human1.12445841
122MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11440900
123CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10909149
124EP300_21415370_ChIP-Seq_HL-1_Mouse1.10801877
125IRF8_21731497_ChIP-ChIP_J774_Mouse1.09043362
126SA1_27219007_Chip-Seq_Bcells_Human1.07536129
127STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06642868
128SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06482357
129ESR1_20079471_ChIP-ChIP_T-47D_Human1.05565638
130GATA1_19941826_ChIP-Seq_K562_Human1.04755496
131CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04750319
132NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04686505
133* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04394783
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03343872
135SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02740728
136PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02515087
137STAT3_23295773_ChIP-Seq_U87_Human1.02312633
138OCT4_19829295_ChIP-Seq_ESCs_Human1.02168732
139* CREB1_26743006_Chip-Seq_LNCaP_Human1.01679980
140SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.01579383
141SMAD_19615063_ChIP-ChIP_OVARY_Human1.01330567
142AHR_22903824_ChIP-Seq_MCF-7_Human1.01083784
143IRF8_27001747_Chip-Seq_BMDM_Mouse1.00933345
144GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00096853
145RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99599282
146* CMYC_18555785_Chip-Seq_ESCs_Mouse0.99438837
147BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99373867
148SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99056832
149HTT_18923047_ChIP-ChIP_STHdh_Human0.98689037
150NANOG_18555785_Chip-Seq_ESCs_Mouse0.98613362
151BCOR_27268052_Chip-Seq_Bcells_Human0.98589743
152GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97826247
153IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97559539
154LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97110299
155EGR1_19032775_ChIP-ChIP_M12_Human0.96807547
156REST_21632747_ChIP-Seq_MESCs_Mouse0.96042793
157PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95989690
158NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95682146
159ARNT_22903824_ChIP-Seq_MCF-7_Human0.95646749
160UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95489411
161PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95184390
162WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95107956
163MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94599429
164RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94577940
165CTCF_20526341_ChIP-Seq_ESCs_Human0.93613757
166RNF2_27304074_Chip-Seq_NSC_Mouse0.93450294
167TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93376850
168PRDM14_20953172_ChIP-Seq_ESCs_Human0.93353421
169RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93293550
170P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93148238
171NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92827364
172* P300_18555785_Chip-Seq_ESCs_Mouse0.92101678
173* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92050431
174TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90637541
175TCF4_23295773_ChIP-Seq_U87_Human0.90386053
176SOX2_19829295_ChIP-Seq_ESCs_Human0.90209887
177NANOG_19829295_ChIP-Seq_ESCs_Human0.90209887
178* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89717976
179PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89348097
180SMAD4_21799915_ChIP-Seq_A2780_Human0.88056040
181TBL1_22424771_ChIP-Seq_293T_Human0.87913959
182TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86376796
183EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86272534
184KDM2B_26808549_Chip-Seq_REH_Human0.85820856
185SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.83977285
186ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83781821

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0000920_abnormal_myelination5.62442973
2MP0010234_abnormal_vibrissa_follicle4.75506305
3MP0003950_abnormal_plasma_membrane4.02118219
4MP0003763_abnormal_thymus_physiology3.77788456
5MP0003880_abnormal_central_pattern3.73784175
6MP0004270_analgesia3.43069043
7MP0003690_abnormal_glial_cell3.04739077
8MP0003329_amyloid_beta_deposits2.90450140
9MP0005671_abnormal_response_to2.88532313
10MP0001529_abnormal_vocalization2.86999360
11MP0004885_abnormal_endolymph2.84672678
12MP0003136_yellow_coat_color2.83507864
13MP0001905_abnormal_dopamine_level2.56063509
14MP0004742_abnormal_vestibular_system2.53392255
15MP0005171_absent_coat_pigmentation2.49374500
16MP0002272_abnormal_nervous_system2.49088802
17MP0003634_abnormal_glial_cell2.43103327
18MP0001486_abnormal_startle_reflex2.38762754
19MP0005451_abnormal_body_composition2.21479170
20MP0004142_abnormal_muscle_tone2.21251381
21MP0005409_darkened_coat_color2.16661541
22MP0009333_abnormal_splenocyte_physiolog2.16651398
23MP0002796_impaired_skin_barrier2.10126486
24MP0001485_abnormal_pinna_reflex2.09909251
25MP0005410_abnormal_fertilization2.06808001
26MP0000778_abnormal_nervous_system2.05176171
27MP0002064_seizures2.04227276
28MP0005000_abnormal_immune_tolerance1.94124655
29MP0001800_abnormal_humoral_immune1.89897006
30MP0003806_abnormal_nucleotide_metabolis1.89806191
31MP0004381_abnormal_hair_follicle1.89143183
32MP0002229_neurodegeneration1.88091685
33MP0004043_abnormal_pH_regulation1.87950216
34MP0003866_abnormal_defecation1.87182648
35MP0003436_decreased_susceptibility_to1.86672187
36MP0005423_abnormal_somatic_nervous1.77570644
37MP0002734_abnormal_mechanical_nocicepti1.75728621
38MP0003632_abnormal_nervous_system1.75697302
39MP0004859_abnormal_synaptic_plasticity1.74721313
40MP0005387_immune_system_phenotype1.74003939
41MP0001790_abnormal_immune_system1.74003939
42MP0009046_muscle_twitch1.71828763
43MP0004947_skin_inflammation1.71739906
44MP0002420_abnormal_adaptive_immunity1.69560855
45MP0000703_abnormal_thymus_morphology1.69165234
46MP0000462_abnormal_digestive_system1.68229938
47MP0003724_increased_susceptibility_to1.64857664
48MP0003300_gastrointestinal_ulcer1.64437273
49MP0001819_abnormal_immune_cell1.63952036
50MP0005025_abnormal_response_to1.63100791
51MP0004147_increased_porphyrin_level1.62750835
52MP0002723_abnormal_immune_serum1.62729508
53MP0010678_abnormal_skin_adnexa1.59494991
54MP0003635_abnormal_synaptic_transmissio1.58791890
55MP0000685_abnormal_immune_system1.58120027
56MP0009745_abnormal_behavioral_response1.57237977
57MP0002398_abnormal_bone_marrow1.51315803
58MP0000604_amyloidosis1.49026393
59MP0000465_gastrointestinal_hemorrhage1.47233626
60MP0003787_abnormal_imprinting1.44246473
61MP0000955_abnormal_spinal_cord1.42144231
62MP0001835_abnormal_antigen_presentation1.40268313
63MP0003879_abnormal_hair_cell1.38844476
64MP0005377_hearing/vestibular/ear_phenot1.38506410
65MP0003878_abnormal_ear_physiology1.38506410
66MP0001873_stomach_inflammation1.37700177
67MP0000716_abnormal_immune_system1.37212118
68MP0000383_abnormal_hair_follicle1.35321713
69MP0003631_nervous_system_phenotype1.34993836
70MP0001765_abnormal_ion_homeostasis1.33841466
71MP0001963_abnormal_hearing_physiology1.30916716
72MP0000747_muscle_weakness1.30907942
73MP0002882_abnormal_neuron_morphology1.30267165
74MP0005551_abnormal_eye_electrophysiolog1.27150414
75MP0003045_fibrosis1.26883989
76MP0004134_abnormal_chest_morphology1.25091359
77MP0001970_abnormal_pain_threshold1.24639291
78MP0004130_abnormal_muscle_cell1.24480150
79MP0002452_abnormal_antigen_presenting1.23920918
80MP0001348_abnormal_lacrimal_gland1.23165519
81MP0008260_abnormal_autophagy1.23075216
82MP0004185_abnormal_adipocyte_glucose1.22987112
83MP0001440_abnormal_grooming_behavior1.22079666
84MP0002148_abnormal_hypersensitivity_rea1.21941053
85MP0008569_lethality_at_weaning1.21726288
86MP0002405_respiratory_system_inflammati1.21613778
87MP0002572_abnormal_emotion/affect_behav1.20003040
88MP0002066_abnormal_motor_capabilities/c1.19686913
89MP0004924_abnormal_behavior1.15885776
90MP0005386_behavior/neurological_phenoty1.15885776
91MP0003633_abnormal_nervous_system1.15628924
92MP0001661_extended_life_span1.15433435
93MP0001851_eye_inflammation1.13169173
94MP0001299_abnormal_eye_distance/1.11121525
95MP0005075_abnormal_melanosome_morpholog1.09374912
96MP0002063_abnormal_learning/memory/cond1.09091692
97MP0005501_abnormal_skin_physiology1.08768147
98MP0001346_abnormal_lacrimal_gland1.08469922
99MP0005623_abnormal_meninges_morphology1.08332125
100MP0002067_abnormal_sensory_capabilities1.07901220
101MP0003075_altered_response_to1.06668133
102MP0002419_abnormal_innate_immunity1.06499255
103MP0010155_abnormal_intestine_physiology1.06184105
104MP0005166_decreased_susceptibility_to1.06055062
105MP0009785_altered_susceptibility_to1.05874132
106MP0002722_abnormal_immune_system1.04484713
107* MP0002752_abnormal_somatic_nervous1.04208051
108MP0003303_peritoneal_inflammation1.03944388
109MP0004145_abnormal_muscle_electrophysio1.03659159
110MP0008438_abnormal_cutaneous_collagen1.01579762
111MP0003195_calcinosis1.01189757
112MP0002733_abnormal_thermal_nociception0.99446864
113MP0005058_abnormal_lysosome_morphology0.98960670
114MP0005310_abnormal_salivary_gland0.96037884
115MP0002166_altered_tumor_susceptibility0.95728742
116MP0005464_abnormal_platelet_physiology0.95196260
117MP0000647_abnormal_sebaceous_gland0.94081241
118MP0002429_abnormal_blood_cell0.92969806
119MP0003453_abnormal_keratinocyte_physiol0.92711859
120MP0002009_preneoplasia0.92473408
121MP0002735_abnormal_chemical_nociception0.92278390
122MP0003937_abnormal_limbs/digits/tail_de0.91467087
123MP0003938_abnormal_ear_development0.91134813
124MP0008874_decreased_physiological_sensi0.90254382
125MP0002933_joint_inflammation0.89814122
126MP0000689_abnormal_spleen_morphology0.89212040
127MP0008961_abnormal_basal_metabolism0.88839170
128MP0000762_abnormal_tongue_morphology0.87645050
129MP0009780_abnormal_chondrocyte_physiolo0.87045564
130MP0009840_abnormal_foam_cell0.85666369
131MP0001968_abnormal_touch/_nociception0.82198210
132MP0000566_synostosis0.81447611
133MP0005666_abnormal_adipose_tissue0.81204002
134* MP0005195_abnormal_posterior_eye0.80743730
135MP0001177_atelectasis0.80475233
136MP0001845_abnormal_inflammatory_respons0.79906329
137MP0005408_hypopigmentation0.78597153
138MP0000026_abnormal_inner_ear0.77139853
139MP0002152_abnormal_brain_morphology0.76792917
140MP0001853_heart_inflammation0.75914226
141MP0004133_heterotaxia0.74874065
142MP0002396_abnormal_hematopoietic_system0.72396201
143MP0000467_abnormal_esophagus_morphology0.70990945
144MP0002295_abnormal_pulmonary_circulatio0.70850872
145MP0004811_abnormal_neuron_physiology0.70762441
146MP0004036_abnormal_muscle_relaxation0.70417836
147MP0001501_abnormal_sleep_pattern0.70339686
148MP0002822_catalepsy0.68135314
149MP0006082_CNS_inflammation0.67992026
150MP0002736_abnormal_nociception_after0.67127181
151MP0003137_abnormal_impulse_conducting0.66554382
152MP0002184_abnormal_innervation0.62882861
153MP0006072_abnormal_retinal_apoptosis0.62662799
154MP0000579_abnormal_nail_morphology0.62124236
155MP0005253_abnormal_eye_physiology0.61389840
156MP0001502_abnormal_circadian_rhythm0.60907408
157MP0002938_white_spotting0.59562011
158MP0001340_abnormal_eyelid_morphology0.58744179
159MP0002557_abnormal_social/conspecific_i0.57115466
160MP0005388_respiratory_system_phenotype0.56557095
161MP0002133_abnormal_respiratory_system0.56557095

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.80879498
2Degeneration of the lateral corticospinal tracts (HP:0002314)6.80879498
3Neurofibrillary tangles (HP:0002185)6.49074280
4Increased IgE level (HP:0003212)5.86050091
5Pustule (HP:0200039)5.22091363
6Abnormality of the corticospinal tract (HP:0002492)4.98159080
7Sensory axonal neuropathy (HP:0003390)4.76132279
8Parakeratosis (HP:0001036)4.74296958
9Peripheral hypomyelination (HP:0007182)4.72813476
10Cerebral inclusion bodies (HP:0100314)4.68112905
11Eczematoid dermatitis (HP:0000976)4.23944762
12Onion bulb formation (HP:0003383)4.19660122
13Hyperactive renin-angiotensin system (HP:0000841)4.00850599
14Oral leukoplakia (HP:0002745)3.97138266
15Abnormality of binocular vision (HP:0011514)3.89127149
16Diplopia (HP:0000651)3.89127149
17Spastic gait (HP:0002064)3.75298909
18Cerebral hypomyelination (HP:0006808)3.74808450
19Abnormal auditory evoked potentials (HP:0006958)3.67875299
20T lymphocytopenia (HP:0005403)3.66634692
21Supranuclear gaze palsy (HP:0000605)3.61427706
22Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.59866818
23Abnormality of T cell number (HP:0011839)3.42875411
24Papilledema (HP:0001085)3.39586611
25Stomatitis (HP:0010280)3.36730288
26Myokymia (HP:0002411)3.33485789
27Intention tremor (HP:0002080)3.29928068
28Dysmetria (HP:0001310)3.25215628
29Insidious onset (HP:0003587)3.24603569
30Termporal pattern (HP:0011008)3.24603569
31Segmental peripheral demyelination/remyelination (HP:0003481)3.19900839
32Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.19767176
33Focal motor seizures (HP:0011153)3.10160318
34Ankle clonus (HP:0011448)3.09810870
35Alacrima (HP:0000522)3.08000567
36Leukodystrophy (HP:0002415)3.05192862
37Scanning speech (HP:0002168)2.98365634
38Obstructive sleep apnea (HP:0002870)2.97887738
39Severe combined immunodeficiency (HP:0004430)2.92874845
40Autoamputation (HP:0001218)2.91330791
41Autoimmune hemolytic anemia (HP:0001890)2.90341991
42Hyperaldosteronism (HP:0000859)2.82811138
43Renal salt wasting (HP:0000127)2.82133897
44Thickened helices (HP:0000391)2.78611892
45Stridor (HP:0010307)2.78251404
46Increased serum pyruvate (HP:0003542)2.76155736
47Abnormality of glycolysis (HP:0004366)2.76155736
48Retinal dysplasia (HP:0007973)2.75535384
49Febrile seizures (HP:0002373)2.72020993
50Slow saccadic eye movements (HP:0000514)2.70589786
51Hemiplegia (HP:0002301)2.68492429
52Hypoplastic pelvis (HP:0008839)2.65062387
53Congenital ichthyosiform erythroderma (HP:0007431)2.62728189
54Abnormality of chloride homeostasis (HP:0011422)2.62042309
55Delusions (HP:0000746)2.61791199
56Clumsiness (HP:0002312)2.61562856
57Abnormality of renin-angiotensin system (HP:0000847)2.58815337
58Foot dorsiflexor weakness (HP:0009027)2.51584893
59Anteriorly placed anus (HP:0001545)2.51408971
60Action tremor (HP:0002345)2.50524881
61Premature skin wrinkling (HP:0100678)2.50202115
62Absent septum pellucidum (HP:0001331)2.50201641
63Cerebral hemorrhage (HP:0001342)2.50190650
64Abnormal delayed hypersensitivity skin test (HP:0002963)2.49383949
65Hypergammaglobulinemia (HP:0010702)2.48771115
66Spastic paraparesis (HP:0002313)2.48705934
67Focal seizures (HP:0007359)2.47323133
68Elevated erythrocyte sedimentation rate (HP:0003565)2.47118298
69Muscle fiber splitting (HP:0003555)2.46760186
70Spastic tetraparesis (HP:0001285)2.43773470
71Metabolic alkalosis (HP:0200114)2.43381634
72Abnormality of T cells (HP:0002843)2.42573296
73Erythroderma (HP:0001019)2.42251630
74Akinesia (HP:0002304)2.37785628
75Recurrent fungal infections (HP:0002841)2.36241284
76Axonal loss (HP:0003447)2.35338473
77CNS hypomyelination (HP:0003429)2.34288745
78Postural instability (HP:0002172)2.34271870
79Abnormality of small intestinal villus morphology (HP:0011472)2.33833312
80Villous atrophy (HP:0011473)2.33833312
81Annular pancreas (HP:0001734)2.33482594
82Increased IgM level (HP:0003496)2.32834119
83Visual hallucinations (HP:0002367)2.32583832
84Urticaria (HP:0001025)2.32049181
85Verrucae (HP:0200043)2.32027657
86Papilloma (HP:0012740)2.32027657
87Absence seizures (HP:0002121)2.31439510
88Nonprogressive disorder (HP:0003680)2.30973456
89Infantile muscular hypotonia (HP:0008947)2.30543248
90Recurrent bacterial skin infections (HP:0005406)2.30492933
91Decreased lacrimation (HP:0000633)2.30331772
92Abnormality of the phalanges of the 2nd finger (HP:0009541)2.29198661
93Abnormality of the foot musculature (HP:0001436)2.28729135
94Meningitis (HP:0001287)2.26687244
95Increased circulating renin level (HP:0000848)2.26628380
96Epileptic encephalopathy (HP:0200134)2.25896091
97Nasal polyposis (HP:0100582)2.25500371
98Granulocytopenia (HP:0001913)2.25094850
99Hepatosplenomegaly (HP:0001433)2.24912669
100Atonic seizures (HP:0010819)2.23852648
101Split foot (HP:0001839)2.22720658
102Decreased motor nerve conduction velocity (HP:0003431)2.21937639
103Erythema (HP:0010783)2.21594837
104Abnormality of the salivary glands (HP:0010286)2.21057812
105Morphological abnormality of the inner ear (HP:0011390)2.20653328
106Hypokalemic alkalosis (HP:0001949)2.19770360
107Myositis (HP:0100614)2.19714440
108Panhypogammaglobulinemia (HP:0003139)2.16488379
109Coronal craniosynostosis (HP:0004440)2.14161545
110Pheochromocytoma (HP:0002666)2.12397717
111Gowers sign (HP:0003391)2.12031051
112Lower limb muscle weakness (HP:0007340)2.12007119
113Adrenal overactivity (HP:0002717)2.11361003
114Hypomagnesemia (HP:0002917)2.10817417
115Hypoplasia of the thymus (HP:0000778)2.10220925
116Memory impairment (HP:0002354)2.09612260
117Methylmalonic acidemia (HP:0002912)2.09582821
118Abnormality of the septum pellucidum (HP:0007375)2.08916162
119Tetraplegia (HP:0002445)2.08052097
120Combined immunodeficiency (HP:0005387)2.07489598
121Abnormality of eosinophils (HP:0001879)2.05654077
122Hyperkalemia (HP:0002153)2.03096879
123Eosinophilia (HP:0001880)2.01619778
124Mediastinal lymphadenopathy (HP:0100721)2.00787189
125Urinary incontinence (HP:0000020)1.99369881
126Ocular albinism (HP:0001107)1.99317536
127Humeroradial synostosis (HP:0003041)1.97291085
128Synostosis involving the elbow (HP:0003938)1.97291085
129Abnormality of the middle phalanges of the toes (HP:0010183)1.96915636
130Hypoplasia of the iris (HP:0007676)1.96681108
131Patchy hypopigmentation of hair (HP:0011365)1.95955653
132Hyporeflexia of lower limbs (HP:0002600)1.95722230
133Lymphopenia (HP:0001888)1.95045092
134White forelock (HP:0002211)1.94645847
135Lip pit (HP:0100267)1.94485842
136Alkalosis (HP:0001948)1.93319871
137Poor speech (HP:0002465)1.93182055
138Recurrent viral infections (HP:0004429)1.92708354
1393-Methylglutaconic aciduria (HP:0003535)1.92123186
140Peripheral demyelination (HP:0011096)1.91523055
141Abnormality of magnesium homeostasis (HP:0004921)1.90640353
142Partial agenesis of the corpus callosum (HP:0001338)1.89965249
143Morphological abnormality of the pyramidal tract (HP:0002062)1.89887684
144Dialeptic seizures (HP:0011146)1.89854592
145Bowel incontinence (HP:0002607)1.89681221
146Vasculitis (HP:0002633)1.88776079
147Recurrent abscess formation (HP:0002722)1.87713656
148Obstructive lung disease (HP:0006536)1.87593097
149Chronic obstructive pulmonary disease (HP:0006510)1.87593097
150Clonus (HP:0002169)1.86893196
151Urinary urgency (HP:0000012)1.86617178
152Progressive cerebellar ataxia (HP:0002073)1.86269445
153Abnormality of nail color (HP:0100643)1.86051919
154Megalencephaly (HP:0001355)1.85349649
155Rigidity (HP:0002063)1.85294868
156Cupped ear (HP:0000378)1.85254091
157Abnormal eating behavior (HP:0100738)1.85191846
158Abnormality of saccadic eye movements (HP:0000570)1.84020380
159Truncal ataxia (HP:0002078)1.83728665
160Distal sensory impairment (HP:0002936)1.81488028
161Hammertoe (HP:0001765)1.81442676
162Neuronal loss in central nervous system (HP:0002529)1.77106531
163Choreoathetosis (HP:0001266)1.75771586
164Neuroendocrine neoplasm (HP:0100634)1.75179862
165Adrenal hypoplasia (HP:0000835)1.75092424
166Abnormal large intestine physiology (HP:0012700)1.74980302
167Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.74905631
168Paraparesis (HP:0002385)1.74587833
169Aplasia involving bones of the upper limbs (HP:0009823)1.73580548
170Aplasia of the phalanges of the hand (HP:0009802)1.73580548
171Aplasia involving bones of the extremities (HP:0009825)1.73580548
172Renal Fanconi syndrome (HP:0001994)1.71751787
173Duplicated collecting system (HP:0000081)1.71004798
174Prolonged neonatal jaundice (HP:0006579)1.69875722
175Partial duplication of thumb phalanx (HP:0009944)1.68208793
176Abnormality of aromatic amino acid family metabolism (HP:0004338)1.62647653
177Septo-optic dysplasia (HP:0100842)1.62483844

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.36365730
2OXSR14.64603328
3RIPK43.30317540
4MAP4K13.10030543
5TXK3.02788592
6EPHB12.95314955
7BCR2.93767474
8PKN12.84690103
9WNK42.60142878
10PBK2.45326549
11CDK192.45298024
12MET2.43588922
13CAMKK12.37220364
14MAPKAPK52.36867776
15LIMK12.31653216
16WNK12.15054325
17CSNK1G32.03566502
18FES2.03021775
19CSNK1A1L1.96051231
20DAPK21.91371442
21PNCK1.81986881
22FGFR21.80256366
23UHMK11.78327724
24NTRK31.70552519
25TESK21.69731093
26CAMK2B1.66134208
27NTRK11.64352949
28NEK61.60403523
29CLK11.59334759
30GRK61.58753934
31CSNK1G11.55158519
32ROCK21.54858135
33FGR1.53100660
34PRPF4B1.52139531
35CSNK1G21.51445321
36ZAP701.49693209
37CAMKK21.46755762
38TNK21.44505147
39SGK21.42821848
40SGK31.41229515
41ICK1.38538955
42SIK21.35317539
43EPHA41.34496004
44PRKD31.33894203
45CAMK2D1.31384622
46CSK1.31175463
47MAP3K111.28759424
48MAP3K21.25893899
49SYK1.25024096
50NLK1.20963703
51GRK51.19958594
52SGK4941.19304592
53SGK2231.19304592
54TYK21.13809088
55MARK11.12158010
56JAK11.11759650
57TRPM71.11103717
58BTK1.10012764
59MINK11.09550052
60MAPK121.09527603
61CASK1.09028890
62MST41.08249724
63MAP3K31.07987037
64MAPK151.07211854
65SMG11.06599686
66CAMK2G1.05396495
67DYRK21.03925355
68RIPK11.03836076
69MAP3K11.03470683
70JAK21.00235068
71LCK0.99579325
72STK380.98884557
73TNIK0.96750421
74MUSK0.95539013
75IKBKE0.93717105
76SCYL20.92803154
77BMPR1B0.91569397
78MARK20.91059043
79HCK0.90245520
80JAK30.89651234
81FGFR30.88820996
82LRRK20.88412249
83CDK140.86727467
84MAP3K70.86632016
85SIK30.85428748
86CAMK10.84828237
87CAMK2A0.84198793
88PAK60.83748405
89PAK30.80417973
90PRKCQ0.80248951
91DAPK10.78267319
92CDK50.78216321
93TRIB30.77573880
94PRKD10.77471634
95PHKG20.75845301
96PHKG10.75845301
97ARAF0.74791163
98ERBB40.74707773
99CDK150.73938529
100TYRO30.73523141
101MAP2K20.71944297
102MAP3K130.71522519
103TAOK10.71079535
104CDK180.68142551
105SGK10.67151022
106ERN10.66786869
107CDK11A0.66603248
108PDPK10.66210300
109FGFR40.65848818
110IRAK40.64086658
111PRKCE0.62521425
112BMPR20.59155207
113TAOK30.58537716
114IRAK20.58014130
115RET0.57238462
116CAMK40.56627422
117CSNK1D0.54938248
118KSR20.54047828
119CDK120.53004865
120FYN0.52976587
121MAPK110.52220334
122PRKCH0.51540087
123RPS6KA50.50824817
124PRKD20.50074904
125PRKG10.47972567
126ALK0.45459189
127CSNK1A10.44201762
128GRK70.43772303
129LYN0.43674326
130TBK10.43045609
131PRKACB0.42332613
132PIK3CA0.42229220
133PRKCZ0.40984882
134SIK10.40079679
135ITK0.39073572
136STK110.38372096
137PAK10.38137335
138GSK3A0.38131545
139MARK30.37534779
140ADRBK20.37499059
141RPS6KA30.37485104
142DAPK30.36917322
143CAMK1G0.36695923
144NTRK20.35093718
145DDR20.34903675
146TAOK20.34115193
147DMPK0.33330964
148BMX0.33242510
149OBSCN0.31940107
150MAPK70.31663191
151PDK10.30789957
152PINK10.30000527
153CSNK1E0.29497985
154PTK2B0.28893829
155GRK10.27010615
156MAPK100.26152684
157PRKACA0.25719432
158INSR0.25625044
159MOS0.24544233
160PDGFRB0.24320355
161IRAK10.24162695
162DYRK1A0.23659694
163HIPK20.23606231
164MAP3K90.22227164

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.00845237
2Steroid biosynthesis_Homo sapiens_hsa001004.53789740
3Fatty acid elongation_Homo sapiens_hsa000624.39794537
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.50265584
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.21336724
6Ether lipid metabolism_Homo sapiens_hsa005653.05268169
7Primary immunodeficiency_Homo sapiens_hsa053402.87908241
8Long-term potentiation_Homo sapiens_hsa047202.53820169
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.52122618
10T cell receptor signaling pathway_Homo sapiens_hsa046602.51386830
11Sulfur metabolism_Homo sapiens_hsa009202.22681216
12Oxidative phosphorylation_Homo sapiens_hsa001902.17233029
13Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.09504932
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.08055312
15Vitamin B6 metabolism_Homo sapiens_hsa007502.02347075
16Histidine metabolism_Homo sapiens_hsa003401.98550108
17Protein export_Homo sapiens_hsa030601.88384813
18Sphingolipid metabolism_Homo sapiens_hsa006001.83846801
19Linoleic acid metabolism_Homo sapiens_hsa005911.72297542
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.71452201
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.66914532
22Parkinsons disease_Homo sapiens_hsa050121.64293369
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.58263864
24Butanoate metabolism_Homo sapiens_hsa006501.57860624
25Axon guidance_Homo sapiens_hsa043601.55705578
26Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.54370411
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54185954
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.51984352
29Alzheimers disease_Homo sapiens_hsa050101.49094063
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48344262
31Acute myeloid leukemia_Homo sapiens_hsa052211.46978339
32B cell receptor signaling pathway_Homo sapiens_hsa046621.46826231
33VEGF signaling pathway_Homo sapiens_hsa043701.43331711
34Non-small cell lung cancer_Homo sapiens_hsa052231.41891322
35Osteoclast differentiation_Homo sapiens_hsa043801.36358176
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.31429382
37Allograft rejection_Homo sapiens_hsa053301.31362529
38Glioma_Homo sapiens_hsa052141.28231550
39Chemokine signaling pathway_Homo sapiens_hsa040621.28009672
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27940166
41Graft-versus-host disease_Homo sapiens_hsa053321.27778652
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26893410
43Arginine and proline metabolism_Homo sapiens_hsa003301.26778729
44Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.26555543
45Measles_Homo sapiens_hsa051621.24942994
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22769731
47Hematopoietic cell lineage_Homo sapiens_hsa046401.21762197
48GABAergic synapse_Homo sapiens_hsa047271.19810564
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16993057
50GnRH signaling pathway_Homo sapiens_hsa049121.16610819
51Nitrogen metabolism_Homo sapiens_hsa009101.15708053
52Serotonergic synapse_Homo sapiens_hsa047261.13778778
53Inositol phosphate metabolism_Homo sapiens_hsa005621.11703456
54Neurotrophin signaling pathway_Homo sapiens_hsa047221.10646045
55Glutamatergic synapse_Homo sapiens_hsa047241.05725130
56Insulin secretion_Homo sapiens_hsa049111.05268927
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03152117
58Oxytocin signaling pathway_Homo sapiens_hsa049211.02620499
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02146249
60NF-kappa B signaling pathway_Homo sapiens_hsa040641.01205658
61Tight junction_Homo sapiens_hsa045301.00281302
62Renal cell carcinoma_Homo sapiens_hsa052110.98756674
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98028177
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96770494
65Endometrial cancer_Homo sapiens_hsa052130.96128212
66Cardiac muscle contraction_Homo sapiens_hsa042600.95159207
67Morphine addiction_Homo sapiens_hsa050320.95000400
68Long-term depression_Homo sapiens_hsa047300.93995090
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93041281
70MAPK signaling pathway_Homo sapiens_hsa040100.92408865
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92256036
72Choline metabolism in cancer_Homo sapiens_hsa052310.90849588
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90246204
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.89691272
75Calcium signaling pathway_Homo sapiens_hsa040200.88550433
76Type I diabetes mellitus_Homo sapiens_hsa049400.87959542
77Chronic myeloid leukemia_Homo sapiens_hsa052200.87068656
78Circadian rhythm_Homo sapiens_hsa047100.86842186
79Glutathione metabolism_Homo sapiens_hsa004800.86198308
80Collecting duct acid secretion_Homo sapiens_hsa049660.86112629
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85371029
82Arachidonic acid metabolism_Homo sapiens_hsa005900.84627379
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.84194355
84Cocaine addiction_Homo sapiens_hsa050300.83003366
85Autoimmune thyroid disease_Homo sapiens_hsa053200.81587579
86Estrogen signaling pathway_Homo sapiens_hsa049150.81159697
87Vibrio cholerae infection_Homo sapiens_hsa051100.80709205
88Pancreatic cancer_Homo sapiens_hsa052120.80540250
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.79756975
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79196064
91Huntingtons disease_Homo sapiens_hsa050160.78421200
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76652727
93Rap1 signaling pathway_Homo sapiens_hsa040150.75402364
94Salmonella infection_Homo sapiens_hsa051320.74764221
95Leishmaniasis_Homo sapiens_hsa051400.74431605
96Phototransduction_Homo sapiens_hsa047440.72903458
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72699681
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72672560
99Mineral absorption_Homo sapiens_hsa049780.72615753
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.71889395
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71795099
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71723425
103Tuberculosis_Homo sapiens_hsa051520.71582516
104Thyroid cancer_Homo sapiens_hsa052160.70403725
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.68567825
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.67929886
107Endocytosis_Homo sapiens_hsa041440.67130324
108Colorectal cancer_Homo sapiens_hsa052100.66515837
109Antigen processing and presentation_Homo sapiens_hsa046120.66307202
110Propanoate metabolism_Homo sapiens_hsa006400.65452708
111Folate biosynthesis_Homo sapiens_hsa007900.65041133
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64180263
113mTOR signaling pathway_Homo sapiens_hsa041500.63976327
114Ovarian steroidogenesis_Homo sapiens_hsa049130.63291615
115Salivary secretion_Homo sapiens_hsa049700.63168580
116Melanogenesis_Homo sapiens_hsa049160.63081053
117Platelet activation_Homo sapiens_hsa046110.62867881
118Fatty acid metabolism_Homo sapiens_hsa012120.62698533
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61677223
120African trypanosomiasis_Homo sapiens_hsa051430.61054958
121Circadian entrainment_Homo sapiens_hsa047130.58953203
122Hepatitis B_Homo sapiens_hsa051610.58851694
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58674563
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.58629910
125Rheumatoid arthritis_Homo sapiens_hsa053230.58535283
126Hedgehog signaling pathway_Homo sapiens_hsa043400.58103179
127Notch signaling pathway_Homo sapiens_hsa043300.57329664
128Ras signaling pathway_Homo sapiens_hsa040140.57132384
129Prolactin signaling pathway_Homo sapiens_hsa049170.57049325
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55927025
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55702428
132Gastric acid secretion_Homo sapiens_hsa049710.55697445
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55441108
134Lysosome_Homo sapiens_hsa041420.55088625
135Dorso-ventral axis formation_Homo sapiens_hsa043200.54415620
136Pancreatic secretion_Homo sapiens_hsa049720.53145982
137Nicotine addiction_Homo sapiens_hsa050330.51882246
138Chemical carcinogenesis_Homo sapiens_hsa052040.50526698
139Malaria_Homo sapiens_hsa051440.47742901
140Metabolic pathways_Homo sapiens_hsa011000.45967146
141Peroxisome_Homo sapiens_hsa041460.45864029
142Phagosome_Homo sapiens_hsa041450.44932663
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44488638
144Dopaminergic synapse_Homo sapiens_hsa047280.43628987
145Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42231905
146Vitamin digestion and absorption_Homo sapiens_hsa049770.41984763
147ECM-receptor interaction_Homo sapiens_hsa045120.41195224
148ErbB signaling pathway_Homo sapiens_hsa040120.39818126
149Prion diseases_Homo sapiens_hsa050200.39545768
150Fatty acid biosynthesis_Homo sapiens_hsa000610.38905719
151Cholinergic synapse_Homo sapiens_hsa047250.37255284
152Renin secretion_Homo sapiens_hsa049240.36923123
153Gap junction_Homo sapiens_hsa045400.36373662
154Tyrosine metabolism_Homo sapiens_hsa003500.35199994
155Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35017851
156Taste transduction_Homo sapiens_hsa047420.32947739
157Retinol metabolism_Homo sapiens_hsa008300.32885445
158beta-Alanine metabolism_Homo sapiens_hsa004100.28919212
159Synaptic vesicle cycle_Homo sapiens_hsa047210.27693608
160Amphetamine addiction_Homo sapiens_hsa050310.27344396
161cAMP signaling pathway_Homo sapiens_hsa040240.27156949
162ABC transporters_Homo sapiens_hsa020100.26959460
163Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24832037
164Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24000464
165Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23409563

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