MAL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)8.66974657
2bundle of His cell to Purkinje myocyte communication (GO:0086069)7.14834149
3regulation of water loss via skin (GO:0033561)5.96109711
4establishment of skin barrier (GO:0061436)5.58965895
5intestinal epithelial cell development (GO:0060576)5.39677609
6vocalization behavior (GO:0071625)5.05582591
7multicellular organismal water homeostasis (GO:0050891)4.89908148
8diterpenoid biosynthetic process (GO:0016102)4.89667834
9glutamate secretion (GO:0014047)4.64703567
10negative regulation of keratinocyte proliferation (GO:0010839)4.50448142
11regulation of short-term neuronal synaptic plasticity (GO:0048172)4.42990482
12keratinocyte proliferation (GO:0043616)4.37876531
13hemidesmosome assembly (GO:0031581)4.25082994
14synaptic vesicle exocytosis (GO:0016079)4.23646624
15water homeostasis (GO:0030104)4.12103354
16COPI coating of Golgi vesicle (GO:0048205)4.07298906
17Golgi transport vesicle coating (GO:0048200)4.07298906
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.06010644
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.05377964
20protein localization to synapse (GO:0035418)4.02081855
21locomotory exploration behavior (GO:0035641)4.01277700
22regulation of glutamate receptor signaling pathway (GO:1900449)3.98567479
23regulation of synaptic vesicle exocytosis (GO:2000300)3.97170359
24gap junction assembly (GO:0016264)3.93809346
25tight junction assembly (GO:0070830)3.93514674
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.90378998
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.85885895
28ionotropic glutamate receptor signaling pathway (GO:0035235)3.80616081
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.78352313
30synaptic vesicle maturation (GO:0016188)3.73191933
31keratinization (GO:0031424)3.70789888
32epithelial cell-cell adhesion (GO:0090136)3.70017069
33synaptic vesicle docking involved in exocytosis (GO:0016081)3.69304586
34glutamate receptor signaling pathway (GO:0007215)3.61484847
35terpenoid biosynthetic process (GO:0016114)3.55809276
36membrane budding (GO:0006900)3.54840140
37negative regulation of dendrite morphogenesis (GO:0050774)3.54034778
38neuron cell-cell adhesion (GO:0007158)3.53893996
39regulation of keratinocyte differentiation (GO:0045616)3.53132856
40regulation of neuronal synaptic plasticity (GO:0048168)3.51220193
41regulation of synaptic vesicle transport (GO:1902803)3.49984918
42positive regulation of epidermal cell differentiation (GO:0045606)3.48678920
43neurotransmitter-gated ion channel clustering (GO:0072578)3.46980063
44activation of Rac GTPase activity (GO:0032863)3.44534478
45exploration behavior (GO:0035640)3.44527482
46neurotransmitter secretion (GO:0007269)3.41629975
47keratinocyte differentiation (GO:0030216)3.36466572
48dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.33215465
49positive regulation of vesicle fusion (GO:0031340)3.32220911
50positive regulation of keratinocyte differentiation (GO:0045618)3.31645650
51branching involved in mammary gland duct morphogenesis (GO:0060444)3.30759657
52righting reflex (GO:0060013)3.29910101
53neuronal action potential propagation (GO:0019227)3.29072071
54keratinocyte development (GO:0003334)3.28706248
55proline transport (GO:0015824)3.27982829
56regulation of keratinocyte proliferation (GO:0010837)3.27238097
57cytoskeletal anchoring at plasma membrane (GO:0007016)3.26748809
58cell-cell junction assembly (GO:0007043)3.26645483
59establishment of tissue polarity (GO:0007164)3.22877049
60establishment of planar polarity (GO:0001736)3.22877049
61neuron-neuron synaptic transmission (GO:0007270)3.22512528
62apical protein localization (GO:0045176)3.22292255
63regulation of dendritic spine morphogenesis (GO:0061001)3.20558199
64synaptic transmission, glutamatergic (GO:0035249)3.20405804
65maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.20085932
66gamma-aminobutyric acid signaling pathway (GO:0007214)3.18952485
67asymmetric protein localization (GO:0008105)3.14495391
68regulation of excitatory postsynaptic membrane potential (GO:0060079)3.13875445
69long-term synaptic potentiation (GO:0060291)3.11725006
70protein retention in ER lumen (GO:0006621)3.10739440
71response to histamine (GO:0034776)3.10606233
72chemical homeostasis within a tissue (GO:0048875)3.10585134
73regulation of vesicle fusion (GO:0031338)3.09420597
74neuron recognition (GO:0008038)3.09003988
75regulation of synaptic plasticity (GO:0048167)3.06641015
76establishment of apical/basal cell polarity (GO:0035089)3.06555578
77negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.05113789
78positive regulation of neurotransmitter secretion (GO:0001956)3.04063076
79COPII vesicle coating (GO:0048208)3.03768799
80ER overload response (GO:0006983)3.03237055
81regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.01768829
82cellular potassium ion homeostasis (GO:0030007)3.01146537
83regulation of postsynaptic membrane potential (GO:0060078)3.00634440
84negative regulation of dendrite development (GO:2000171)2.99442914
85nucleotide-sugar biosynthetic process (GO:0009226)2.99212529
86mammary gland alveolus development (GO:0060749)2.98786052
87polarized epithelial cell differentiation (GO:0030859)2.97806921
88postsynaptic membrane organization (GO:0001941)2.97413549
89negative regulation of synaptic transmission, GABAergic (GO:0032229)2.96491759
90epidermal cell differentiation (GO:0009913)2.95504849
91auditory behavior (GO:0031223)2.90575480
92O-glycan processing (GO:0016266)2.88928922
93vesicle transport along microtubule (GO:0047496)2.88448583
94negative regulation of cell fate specification (GO:0009996)2.85952988
95mammary gland epithelial cell proliferation (GO:0033598)2.85002578
96layer formation in cerebral cortex (GO:0021819)2.84577377
97neurotransmitter transport (GO:0006836)2.82486294
98long-term memory (GO:0007616)2.81622313
99regulation of glutamate secretion (GO:0014048)2.81592270
100primary alcohol catabolic process (GO:0034310)2.81519693
101synaptic vesicle endocytosis (GO:0048488)2.80996233
102behavioral response to cocaine (GO:0048148)2.80911898
103regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.79656785
104behavioral fear response (GO:0001662)2.79549549
105behavioral defense response (GO:0002209)2.79549549
106regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.77586103
107axonal fasciculation (GO:0007413)2.75822106
108cellular glucuronidation (GO:0052695)2.75623412
109presynaptic membrane assembly (GO:0097105)2.74046831
110positive regulation of synapse maturation (GO:0090129)2.74044110
111cochlea development (GO:0090102)2.72801302
112positive regulation of Cdc42 GTPase activity (GO:0043089)2.72413469
113skin morphogenesis (GO:0043589)2.72080907
114protein autoprocessing (GO:0016540)2.71958768
115regulation of female receptivity (GO:0045924)2.71449711
116ventricular cardiac muscle cell action potential (GO:0086005)2.70688380
117epithelial cell maturation (GO:0002070)2.69215334
118cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.68765019
119regulation of transforming growth factor beta2 production (GO:0032909)2.68282841
120fear response (GO:0042596)2.68087358
121surfactant homeostasis (GO:0043129)2.67825114
122regulation of dendritic spine development (GO:0060998)2.64359517
123positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.63891327
124cellular response to nitric oxide (GO:0071732)2.63768721
125regulation of synaptic transmission, glutamatergic (GO:0051966)2.63328406
126gamma-aminobutyric acid transport (GO:0015812)2.62461151
127protein localization to microtubule (GO:0035372)2.62218919
128female mating behavior (GO:0060180)2.61837530
129cell communication involved in cardiac conduction (GO:0086065)2.61770634
130cellular sodium ion homeostasis (GO:0006883)2.61627136
131positive regulation of membrane potential (GO:0045838)2.60971559
132negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.60561578
133positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.60446007
134dendritic spine morphogenesis (GO:0060997)2.60428113
135hippo signaling (GO:0035329)2.60367130
136regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.60046087
137positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.60020190
138positive regulation of neurotransmitter transport (GO:0051590)2.60006654
139membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.59776117
140G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.59507611
141activation of protein kinase A activity (GO:0034199)2.58479704
142long term synaptic depression (GO:0060292)2.58282146
143notochord development (GO:0030903)2.58036703
144lung epithelium development (GO:0060428)2.57944683
145regulation of neurotransmitter levels (GO:0001505)2.57674298
146morphogenesis of embryonic epithelium (GO:0016331)2.57384670
147mechanosensory behavior (GO:0007638)2.55568812
148regulation of epidermal cell differentiation (GO:0045604)2.54968195
149membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.54867516
150retinal metabolic process (GO:0042574)2.54680508
151regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.54524851
152maternal placenta development (GO:0001893)2.54343038
153regulation of synapse structural plasticity (GO:0051823)2.54285187
154learning (GO:0007612)2.53589501
155negative regulation of sodium ion transport (GO:0010766)2.53390294
156dendritic spine organization (GO:0097061)2.53079064
157regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.52855527
158epidermis development (GO:0008544)2.52749649
159glucuronate metabolic process (GO:0019585)2.52114872
160uronic acid metabolic process (GO:0006063)2.52114872
161proline biosynthetic process (GO:0006561)2.51965999
162regulation of cholesterol homeostasis (GO:2000188)2.51808266
163Leydig cell differentiation (GO:0033327)2.51739534
164protein complex localization (GO:0031503)2.51597025
165iron ion import (GO:0097286)2.51468309
166cellular protein complex localization (GO:0034629)2.51022128
167calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.50764479
168G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50004632
169positive regulation of epidermis development (GO:0045684)2.49666069
170epithelial cell differentiation involved in prostate gland development (GO:0060742)2.49657434
171regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.48837323
172regulation of neurotransmitter secretion (GO:0046928)2.48163105
173presynaptic membrane organization (GO:0097090)2.48082916
174retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.47923814
175establishment or maintenance of bipolar cell polarity (GO:0061245)2.47545584
176establishment or maintenance of apical/basal cell polarity (GO:0035088)2.47545584
177lung lobe morphogenesis (GO:0060463)2.47542542
178regulation of cardioblast differentiation (GO:0051890)2.47529651
179regulation of clathrin-mediated endocytosis (GO:2000369)2.47489671
180semaphorin-plexin signaling pathway (GO:0071526)2.46968195
181regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.46753151
182detection of calcium ion (GO:0005513)2.45565322
183regulation of transcription from RNA polymerase I promoter (GO:0006356)2.45361420
184positive regulation of protein localization to plasma membrane (GO:1903078)2.44925733
185innervation (GO:0060384)2.44038358
186phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.43145831
187columnar/cuboidal epithelial cell development (GO:0002066)2.42848615
188response to auditory stimulus (GO:0010996)2.41858963
189positive regulation of cardiac muscle hypertrophy (GO:0010613)2.41019282
190positive regulation of muscle hypertrophy (GO:0014742)2.41019282
191ear development (GO:0043583)2.40648726
192regulation of cholesterol biosynthetic process (GO:0045540)2.40192624
193purine nucleotide transport (GO:0015865)2.39666910
194embryonic eye morphogenesis (GO:0048048)2.39209163
195flavonoid metabolic process (GO:0009812)2.38944865
196ectoderm development (GO:0007398)2.38927456
197hypotonic response (GO:0006971)2.38218824

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.66181531
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.04168759
3ESR1_21235772_ChIP-Seq_MCF-7_Human4.30920520
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.13056652
5EZH2_22144423_ChIP-Seq_EOC_Human4.00850442
6ZNF263_19887448_ChIP-Seq_K562_Human3.69126395
7* GBX2_23144817_ChIP-Seq_PC3_Human3.28844890
8AR_21909140_ChIP-Seq_LNCAP_Human3.10983392
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89013647
10KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.86334696
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.77010119
12CDX2_20551321_ChIP-Seq_CACO-2_Human2.60042294
13SOX2_27498859_Chip-Seq_STOMACH_Mouse2.58882950
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47066410
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46035257
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.45410819
17* SOX2_20726797_ChIP-Seq_SW620_Human2.35673599
18* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.34026827
19* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.34026827
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30388044
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29543313
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29543313
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.29169767
24GATA6_25053715_ChIP-Seq_YYC3_Human2.28257441
25KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human2.25614045
26RACK7_27058665_Chip-Seq_MCF-7_Human2.23381244
27* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22157102
28TAF15_26573619_Chip-Seq_HEK293_Human2.22050378
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.20527181
30GATA3_24758297_ChIP-Seq_MCF-7_Human2.19120556
31PPAR_26484153_Chip-Seq_NCI-H1993_Human2.18463754
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18247931
33* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18150954
34RUNX1_27514584_Chip-Seq_MCF-7_Human2.17180196
35FOXO3_23340844_ChIP-Seq_DLD1_Human2.13306564
36FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human2.07082144
37SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.06714960
38EED_16625203_ChIP-ChIP_MESCs_Mouse2.03431090
39ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human2.02773349
40ESR1_20079471_ChIP-ChIP_T-47D_Human2.01941074
41CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01111602
42ESR1_15608294_ChIP-ChIP_MCF-7_Human1.98202714
43CLOCK_20551151_ChIP-Seq_293T_Human1.94073083
44* RARB_27405468_Chip-Seq_BRAIN_Mouse1.89431519
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88937533
46* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.88344143
47* PIAS1_25552417_ChIP-Seq_VCAP_Human1.87904480
48REST_21632747_ChIP-Seq_MESCs_Mouse1.85964902
49EZH2_27304074_Chip-Seq_ESCs_Mouse1.85495721
50* ATF3_27146783_Chip-Seq_COLON_Human1.83029350
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82463640
52SMAD4_21799915_ChIP-Seq_A2780_Human1.82460810
53* GATA4_25053715_ChIP-Seq_YYC3_Human1.80010252
54DROSHA_22980978_ChIP-Seq_HELA_Human1.79519005
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73641546
56SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70332163
57P300_19829295_ChIP-Seq_ESCs_Human1.67967374
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.64776305
59CHD1_26751641_Chip-Seq_LNCaP_Human1.63830840
60AHR_22903824_ChIP-Seq_MCF-7_Human1.63543569
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.62872905
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.62644531
63P63_26484246_Chip-Seq_KERATINOCYTES_Human1.62602007
64FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.61303742
65VDR_22108803_ChIP-Seq_LS180_Human1.61202044
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61117343
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.58228928
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57921480
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57295434
70SOX9_24532713_ChIP-Seq_HFSC_Mouse1.56925350
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.53987500
72* ELF5_23300383_ChIP-Seq_T47D_Human1.53132889
73KLF5_25053715_ChIP-Seq_YYC3_Human1.52683585
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51754237
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51298566
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51135318
77AR_21572438_ChIP-Seq_LNCaP_Human1.50529756
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49141222
79EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.48940776
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48804607
81TP53_18474530_ChIP-ChIP_U2OS_Human1.47523373
82* AR_25329375_ChIP-Seq_VCAP_Human1.47298976
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44154023
84REST_18959480_ChIP-ChIP_MESCs_Mouse1.43036830
85BCAT_22108803_ChIP-Seq_LS180_Human1.42099260
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.41997791
87FUS_26573619_Chip-Seq_HEK293_Human1.41048236
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40401386
89NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39838680
90* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38466578
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36619250
92NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36432692
93HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.36194277
94* RXR_22158963_ChIP-Seq_LIVER_Mouse1.35956088
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35915550
96CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35674249
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34692901
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33920163
99BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33794330
100ZNF274_21170338_ChIP-Seq_K562_Hela1.32808839
101* SOX2_21211035_ChIP-Seq_LN229_Gbm1.32168761
102STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.32041703
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28812586
104ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28664064
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27756296
106TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27136207
107POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26756065
108NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26091443
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26091443
110* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24763316
111* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22449214
112KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22310455
113TP53_16413492_ChIP-PET_HCT116_Human1.22300692
114ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22225089
115* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.21736271
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21436920
117* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21423888
118PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21192749
119CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.20936039
120ESR2_21235772_ChIP-Seq_MCF-7_Human1.20085697
121ERG_21242973_ChIP-ChIP_JURKAT_Human1.19811827
122FOXA1_25552417_ChIP-Seq_VCAP_Human1.18821289
123STAT3_23295773_ChIP-Seq_U87_Human1.18499231
124PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14861831
125P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14469104
126EP300_21415370_ChIP-Seq_HL-1_Mouse1.13050074
127NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12278282
128JUN_21703547_ChIP-Seq_K562_Human1.11065714
129* TCF4_23295773_ChIP-Seq_U87_Human1.11009510
130LXR_22158963_ChIP-Seq_LIVER_Mouse1.10702954
131BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10480039
132TRIM28_21343339_ChIP-Seq_HEK293_Human1.08950949
133ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08507405
134WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06911382
135TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06886443
136FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06866014
137* RUNX2_22187159_ChIP-Seq_PCA_Human1.06296295
138AR_19668381_ChIP-Seq_PC3_Human1.06162764
139FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.05992688
140* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05354760
141TCF4_22108803_ChIP-Seq_LS180_Human1.05100665
142KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04449700
143* FOXA2_19822575_ChIP-Seq_HepG2_Human1.04386413
144* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04263576
145TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04233632
146TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04019281
147SMAD3_21741376_ChIP-Seq_HESCs_Human1.03761126
148CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03535343
149SMAD4_21741376_ChIP-Seq_HESCs_Human1.03331310
150PRDM14_20953172_ChIP-Seq_ESCs_Human1.02462005
151ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02382394
152ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01265722
153WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00775841
154SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00701668
155UBF1/2_26484160_Chip-Seq_HMECs_Human1.00364445
156ER_23166858_ChIP-Seq_MCF-7_Human0.99961975
157TP63_23658742_ChIP-Seq_EP156T_Human0.99601246
158P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98793664
159RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97773812
160RING1B_27294783_Chip-Seq_ESCs_Mouse0.97472277
161FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97126888
162TCF4_18268006_ChIP-ChIP_LS174T_Human0.96616953
163KDM2B_26808549_Chip-Seq_REH_Human0.96211097
164BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96159935
165TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95173220
166FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95028357
167PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93798226
168DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90238561
169SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89067467
170CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88657278
171CREB1_26743006_Chip-Seq_LNCaP_Human0.87599515
172SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85729981
173TCF3_18692474_ChIP-Seq_MEFs_Mouse0.84906966
174NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.84268073
175PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83190718
176TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.80157226
177TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.79549929
178ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.79039451
179PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78657073
180NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.76296908
181* CJUN_26792858_Chip-Seq_BT549_Human0.76092334
182ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.75102736
183RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.74992953
184UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.74705782
185HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74198582

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.71028700
2MP0003880_abnormal_central_pattern4.71624245
3MP0004264_abnormal_extraembryonic_tissu4.09740939
4MP0003635_abnormal_synaptic_transmissio3.35538497
5MP0001968_abnormal_touch/_nociception3.33651039
6MP0004270_analgesia3.20027927
7MP0002736_abnormal_nociception_after3.07795785
8MP0005501_abnormal_skin_physiology2.97508070
9MP0002063_abnormal_learning/memory/cond2.83715705
10MP0009745_abnormal_behavioral_response2.80087037
11MP0002139_abnormal_hepatobiliary_system2.78406653
12MP0010352_gastrointestinal_tract_polyps2.64386638
13MP0010234_abnormal_vibrissa_follicle2.52438823
14MP0002735_abnormal_chemical_nociception2.47548477
15MP0002098_abnormal_vibrissa_morphology2.47143995
16MP0000579_abnormal_nail_morphology2.45530553
17MP0003453_abnormal_keratinocyte_physiol2.42306784
18MP0005085_abnormal_gallbladder_physiolo2.40772178
19MP0000383_abnormal_hair_follicle2.39606990
20MP0002064_seizures2.37215844
21MP0002572_abnormal_emotion/affect_behav2.30978487
22MP0001440_abnormal_grooming_behavior2.28296613
23MP0001216_abnormal_epidermal_layer2.18085197
24MP0002822_catalepsy2.16762857
25MP0001501_abnormal_sleep_pattern2.15310863
26MP0002734_abnormal_mechanical_nocicepti2.14907162
27MP0008875_abnormal_xenobiotic_pharmacok2.12438166
28MP0009780_abnormal_chondrocyte_physiolo2.11383362
29MP0003941_abnormal_skin_development2.08054739
30MP0003329_amyloid_beta_deposits1.97231201
31MP0005360_urolithiasis1.96247082
32MP0003705_abnormal_hypodermis_morpholog1.96117302
33MP0004185_abnormal_adipocyte_glucose1.94670358
34MP0000467_abnormal_esophagus_morphology1.92348617
35MP0002272_abnormal_nervous_system1.91202295
36MP0000762_abnormal_tongue_morphology1.91107617
37MP0002733_abnormal_thermal_nociception1.88205132
38MP0002138_abnormal_hepatobiliary_system1.76486514
39MP0000377_abnormal_hair_follicle1.76116265
40MP0003566_abnormal_cell_adhesion1.74302280
41MP0001177_atelectasis1.73063033
42MP0005076_abnormal_cell_differentiation1.70983328
43MP0009046_muscle_twitch1.67926140
44MP0001486_abnormal_startle_reflex1.67489736
45MP0010771_integument_phenotype1.67049101
46MP0002060_abnormal_skin_morphology1.63899954
47MP0000627_abnormal_mammary_gland1.59368157
48MP0001970_abnormal_pain_threshold1.57954185
49MP0005083_abnormal_biliary_tract1.53597491
50MP0005365_abnormal_bile_salt1.52176507
51MP0001529_abnormal_vocalization1.51865204
52MP0002067_abnormal_sensory_capabilities1.49192676
53MP0008995_early_reproductive_senescence1.49123245
54MP0002909_abnormal_adrenal_gland1.47802331
55MP0003191_abnormal_cellular_cholesterol1.47676810
56MP0004858_abnormal_nervous_system1.47652350
57MP0006276_abnormal_autonomic_nervous1.44762435
58MP0004782_abnormal_surfactant_physiolog1.40779592
59MP0004924_abnormal_behavior1.40290310
60MP0005386_behavior/neurological_phenoty1.40290310
61MP0001188_hyperpigmentation1.36681615
62MP0004957_abnormal_blastocyst_morpholog1.36072472
63MP0002877_abnormal_melanocyte_morpholog1.35821431
64MP0000778_abnormal_nervous_system1.33752692
65MP0002184_abnormal_innervation1.33177734
66MP0002557_abnormal_social/conspecific_i1.29972701
67MP0003787_abnormal_imprinting1.27531165
68MP0002837_dystrophic_cardiac_calcinosis1.26649140
69MP0001664_abnormal_digestion1.24796019
70MP0003693_abnormal_embryo_hatching1.22840157
71MP0008872_abnormal_physiological_respon1.20559915
72MP0001958_emphysema1.19003226
73MP0002876_abnormal_thyroid_physiology1.18145793
74MP0001881_abnormal_mammary_gland1.17174143
75MP0001666_abnormal_nutrient_absorption1.16710232
76MP0003315_abnormal_perineum_morphology1.16515104
77MP0008004_abnormal_stomach_pH1.15066757
78MP0001346_abnormal_lacrimal_gland1.14200293
79MP0009379_abnormal_foot_pigmentation1.07321684
80MP0004043_abnormal_pH_regulation1.07225913
81MP0004272_abnormal_basement_membrane1.06663698
82MP0004811_abnormal_neuron_physiology1.06088875
83MP0010386_abnormal_urinary_bladder1.04183525
84MP0005023_abnormal_wound_healing1.01329159
85MP0005248_abnormal_Harderian_gland0.99330383
86MP0003879_abnormal_hair_cell0.99320211
87MP0005275_abnormal_skin_tensile0.98686736
88MP0000427_abnormal_hair_cycle0.98460455
89MP0000604_amyloidosis0.98224487
90MP0010329_abnormal_lipoprotein_level0.97563593
91MP0008569_lethality_at_weaning0.96639133
92MP0001905_abnormal_dopamine_level0.96365585
93MP0002089_abnormal_postnatal_growth/wei0.95103694
94MP0002066_abnormal_motor_capabilities/c0.94584622
95MP0003943_abnormal_hepatobiliary_system0.94449022
96MP0003633_abnormal_nervous_system0.93365282
97MP0003183_abnormal_peptide_metabolism0.92617350
98MP0000647_abnormal_sebaceous_gland0.92356897
99MP0005084_abnormal_gallbladder_morpholo0.92008093
100MP0002133_abnormal_respiratory_system0.91588685
101MP0005388_respiratory_system_phenotype0.91588685
102MP0003631_nervous_system_phenotype0.91405025
103MP0003890_abnormal_embryonic-extraembry0.91217897
104MP0000955_abnormal_spinal_cord0.90683636
105MP0004484_altered_response_of0.90484756
106MP0000678_abnormal_parathyroid_gland0.89839946
107MP0001984_abnormal_olfaction0.88145765
108MP0005666_abnormal_adipose_tissue0.87610775
109MP0003868_abnormal_feces_composition0.87289579
110MP0009931_abnormal_skin_appearance0.87183487
111MP0000477_abnormal_intestine_morphology0.86566304
112MP0004885_abnormal_endolymph0.86391747
113MP0002086_abnormal_extraembryonic_tissu0.86342463
114MP0001765_abnormal_ion_homeostasis0.86186316
115MP0000537_abnormal_urethra_morphology0.85664792
116MP0005408_hypopigmentation0.84510089
117MP0010678_abnormal_skin_adnexa0.83276000
118MP0002882_abnormal_neuron_morphology0.82881317
119MP0001730_embryonic_growth_arrest0.82048630
120MP0005167_abnormal_blood-brain_barrier0.81757250
121MP0002796_impaired_skin_barrier0.81358079
122MP0003936_abnormal_reproductive_system0.81187095
123MP0005423_abnormal_somatic_nervous0.81064582
124MP0003806_abnormal_nucleotide_metabolis0.80385384
125MP0009672_abnormal_birth_weight0.80279664
126MP0005409_darkened_coat_color0.79796736
127MP0003632_abnormal_nervous_system0.78678794
128MP0000470_abnormal_stomach_morphology0.78431988
129MP0005535_abnormal_body_temperature0.78350379
130MP0004883_abnormal_blood_vessel0.78297565
131MP0000566_synostosis0.76783040
132MP0003123_paternal_imprinting0.76664569
133MP0003252_abnormal_bile_duct0.76460913
134MP0005332_abnormal_amino_acid0.76330006
135MP0010368_abnormal_lymphatic_system0.76291507
136MP0001849_ear_inflammation0.75714097
137MP0008874_decreased_physiological_sensi0.75360415
138MP0002234_abnormal_pharynx_morphology0.75181741
139MP0001502_abnormal_circadian_rhythm0.74642719
140MP0009053_abnormal_anal_canal0.74419393
141MP0002069_abnormal_eating/drinking_beha0.73671588
142MP0010030_abnormal_orbit_morphology0.73035324
143MP0002233_abnormal_nose_morphology0.72756910
144MP0001727_abnormal_embryo_implantation0.71334676
145MP0001697_abnormal_embryo_size0.70604742
146MP0005380_embryogenesis_phenotype0.70411753
147MP0001672_abnormal_embryogenesis/_devel0.70411753
148MP0000613_abnormal_salivary_gland0.69988887
149MP0003638_abnormal_response/metabolism_0.69895555
150MP0004085_abnormal_heartbeat0.69431599
151MP0003984_embryonic_growth_retardation0.68974147
152MP0002084_abnormal_developmental_patter0.67923901
153MP0002085_abnormal_embryonic_tissue0.67639521
154MP0001340_abnormal_eyelid_morphology0.67407605
155MP0002088_abnormal_embryonic_growth/wei0.67305854
156MP0003950_abnormal_plasma_membrane0.67148903
157MP0000367_abnormal_coat/_hair0.66822069
158MP0005646_abnormal_pituitary_gland0.66110332
159MP0002697_abnormal_eye_size0.65761356
160MP0001873_stomach_inflammation0.65596758
161MP0000462_abnormal_digestive_system0.64853714
162MP0003937_abnormal_limbs/digits/tail_de0.64768575
163MP0005187_abnormal_penis_morphology0.64497919
164MP0005220_abnormal_exocrine_pancreas0.63668846
165MP0002111_abnormal_tail_morphology0.63465392
166MP0003075_altered_response_to0.63151191
167MP0005636_abnormal_mineral_homeostasis0.62753517
168MP0005451_abnormal_body_composition0.62198374
169MP0003115_abnormal_respiratory_system0.61544480
170MP0004019_abnormal_vitamin_homeostasis0.60771822
171MP0002080_prenatal_lethality0.60271117
172MP0000538_abnormal_urinary_bladder0.59273174
173MP0004233_abnormal_muscle_weight0.57783482
174MP0002896_abnormal_bone_mineralization0.57321504

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.22601793
2Myokymia (HP:0002411)4.62708049
3Pili torti (HP:0003777)4.50817064
4Focal seizures (HP:0007359)4.25348556
5Hyperventilation (HP:0002883)4.10419057
6Epileptic encephalopathy (HP:0200134)3.97398040
7Atonic seizures (HP:0010819)3.90525490
8Visual hallucinations (HP:0002367)3.64650434
9Lip pit (HP:0100267)3.55222422
10Hyperactive renin-angiotensin system (HP:0000841)3.53921409
11Absent eyebrow (HP:0002223)3.52454709
12Abnormality of nail color (HP:0100643)3.51398653
13Gout (HP:0001997)3.46695515
14Progressive cerebellar ataxia (HP:0002073)3.45442424
15Hypotrichosis (HP:0001006)3.35334662
16Absence seizures (HP:0002121)3.33971509
17Tubulointerstitial fibrosis (HP:0005576)3.31507740
18Abnormal hair laboratory examination (HP:0003328)3.27390356
19Plantar hyperkeratosis (HP:0007556)3.25323654
20Septate vagina (HP:0001153)3.25300013
21Cerebral inclusion bodies (HP:0100314)3.19884431
22Abnormality of chloride homeostasis (HP:0011422)3.12595759
23Febrile seizures (HP:0002373)3.12122213
24Flat acetabular roof (HP:0003180)3.11162005
25Generalized tonic-clonic seizures (HP:0002069)3.07121692
26Dialeptic seizures (HP:0011146)3.04724641
27Alopecia of scalp (HP:0002293)3.04665604
28Palmoplantar hyperkeratosis (HP:0000972)2.99523476
29Abnormality of the dental root (HP:0006486)2.98338419
30Taurodontia (HP:0000679)2.98338419
31Abnormality of permanent molar morphology (HP:0011071)2.98338419
32Interstitial pulmonary disease (HP:0006530)2.90756774
33Pterygium (HP:0001059)2.85381285
34Onycholysis (HP:0001806)2.85129103
35Palmar hyperkeratosis (HP:0010765)2.83217317
36Abnormality of the salivary glands (HP:0010286)2.80365179
37Absent eyelashes (HP:0000561)2.80269426
38Neurofibrillary tangles (HP:0002185)2.79315030
39Abnormality of the gastric mucosa (HP:0004295)2.78343906
40Broad-based gait (HP:0002136)2.77631713
41Woolly hair (HP:0002224)2.76974350
42Sparse eyelashes (HP:0000653)2.76807080
43Hypoplasia of dental enamel (HP:0006297)2.66857847
44Congenital ichthyosiform erythroderma (HP:0007431)2.65557083
45Abnormality of molar (HP:0011077)2.64725577
46Abnormality of molar morphology (HP:0011070)2.64725577
47Abnormality of the dental pulp (HP:0006479)2.62486160
48Popliteal pterygium (HP:0009756)2.58748460
49Tubulointerstitial abnormality (HP:0001969)2.57945096
50Anxiety (HP:0000739)2.57585058
51Amelogenesis imperfecta (HP:0000705)2.53907414
52Tubulointerstitial nephritis (HP:0001970)2.52242629
53Vascular calcification (HP:0004934)2.51478474
54Amblyopia (HP:0000646)2.51357412
55Abnormality of monocarboxylic acid metabolism (HP:0010996)2.47294705
56Micronodular cirrhosis (HP:0001413)2.46213721
57Abnormality of the distal phalanges of the toes (HP:0010182)2.45910534
58Milia (HP:0001056)2.42491705
59Action tremor (HP:0002345)2.41244706
60Deep venous thrombosis (HP:0002625)2.36595016
61Vaginal atresia (HP:0000148)2.35743931
62Scanning speech (HP:0002168)2.34352791
63Genital tract atresia (HP:0001827)2.33455042
64Hypoplastic labia majora (HP:0000059)2.28225784
65Tachypnea (HP:0002789)2.26661724
66Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.26030361
67Nail dystrophy (HP:0008404)2.25362226
68Genetic anticipation (HP:0003743)2.23782799
69Hyponatremia (HP:0002902)2.22672289
70Abnormality of renin-angiotensin system (HP:0000847)2.20928061
71Supranuclear gaze palsy (HP:0000605)2.20691508
72Fair hair (HP:0002286)2.19178153
73Torticollis (HP:0000473)2.19030397
74Gaze-evoked nystagmus (HP:0000640)2.17866997
75Exotropia (HP:0000577)2.16995268
76Advanced eruption of teeth (HP:0006288)2.16982055
77Poor eye contact (HP:0000817)2.16588672
78Short nail (HP:0001799)2.16044857
79Abnormal tarsal ossification (HP:0008369)2.15833551
80Decreased circulating renin level (HP:0003351)2.15128506
81Chronic bronchitis (HP:0004469)2.15075379
82Ankyloglossia (HP:0010296)2.15032440
83Ridged nail (HP:0001807)2.12207731
84Dysdiadochokinesis (HP:0002075)2.10594475
85Progressive sensorineural hearing impairment (HP:0000408)2.09309905
86Blue irides (HP:0000635)2.08917209
87Anophthalmia (HP:0000528)2.08447404
88Drooling (HP:0002307)2.08260472
89Excessive salivation (HP:0003781)2.08260472
90Pheochromocytoma (HP:0002666)2.07794272
91Urinary bladder sphincter dysfunction (HP:0002839)2.07622587
92Selective tooth agenesis (HP:0001592)2.07120145
93Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.06987842
94Postural instability (HP:0002172)2.05619516
95Impaired social interactions (HP:0000735)2.04576523
96Abnormal social behavior (HP:0012433)2.04576523
97Germ cell neoplasia (HP:0100728)2.04326791
98Hyperglycinemia (HP:0002154)2.03244891
99Cerebral hemorrhage (HP:0001342)2.02864226
100Status epilepticus (HP:0002133)2.02718738
101Truncal ataxia (HP:0002078)2.02570359
102Epileptiform EEG discharges (HP:0011182)2.01673246
103Thick nail (HP:0001805)2.01559339
104Aplasia involving bones of the upper limbs (HP:0009823)2.01371435
105Aplasia of the phalanges of the hand (HP:0009802)2.01371435
106Aplasia involving bones of the extremities (HP:0009825)2.01371435
107Cardiovascular calcification (HP:0011915)2.00951638
108Insidious onset (HP:0003587)2.00696940
109Termporal pattern (HP:0011008)2.00696940
110Focal dystonia (HP:0004373)2.00590664
111Right ventricular cardiomyopathy (HP:0011663)2.00476886
112Thickened helices (HP:0000391)1.99448865
113Dehydration (HP:0001944)1.98595196
114Focal segmental glomerulosclerosis (HP:0000097)1.98247935
115Deviation of the thumb (HP:0009603)1.97742600
116Absent speech (HP:0001344)1.96650791
117Abnormality of the labia majora (HP:0012881)1.95317661
118Respiratory distress (HP:0002098)1.95215709
119Abnormality of sodium homeostasis (HP:0010931)1.95190612
120Impaired vibration sensation in the lower limbs (HP:0002166)1.94053946
121Dysmetric saccades (HP:0000641)1.92878414
122Glomerulosclerosis (HP:0000096)1.92122479
123Hyperphosphatemia (HP:0002905)1.91616526
124Incomplete penetrance (HP:0003829)1.91587991
125Tetraparesis (HP:0002273)1.91002920
126Bilateral microphthalmos (HP:0007633)1.89917897
127Double outlet right ventricle (HP:0001719)1.89534132
128Congenital malformation of the right heart (HP:0011723)1.89534132
129Blepharitis (HP:0000498)1.88839235
130Abnormality of the nasal septum (HP:0000419)1.88535571
131Craniofacial dystonia (HP:0012179)1.87647431
132Abnormality of binocular vision (HP:0011514)1.87556001
133Diplopia (HP:0000651)1.87556001
134Increased purine levels (HP:0004368)1.87111410
135Hyperuricemia (HP:0002149)1.87111410
136Renal hypoplasia (HP:0000089)1.87036284
137Bifid scrotum (HP:0000048)1.86558301
138Abnormality of the axillary hair (HP:0100134)1.86241832
139Abnormality of secondary sexual hair (HP:0009888)1.86241832
140Abnormality of carpal bone ossification (HP:0006257)1.86041107
141Urinary urgency (HP:0000012)1.86024373
142Midline defect of the nose (HP:0004122)1.85759624
143Abnormality of aromatic amino acid family metabolism (HP:0004338)1.85112104
144Renal salt wasting (HP:0000127)1.85040628
145Delusions (HP:0000746)1.84712975
146Absent hair (HP:0002298)1.84134925
147Dysmetria (HP:0001310)1.83550566
148Generalized myoclonic seizures (HP:0002123)1.83452941
149Conjugated hyperbilirubinemia (HP:0002908)1.83345949
150Dysautonomia (HP:0002459)1.83308387
151Intrahepatic cholestasis (HP:0001406)1.82582027
152Arterial tortuosity (HP:0005116)1.82488952
153Deep palmar crease (HP:0006191)1.81868747
154Asymmetry of the thorax (HP:0001555)1.81095931
155Labial hypoplasia (HP:0000066)1.80420622
156Hypokinesia (HP:0002375)1.80126682
157Bradykinesia (HP:0002067)1.79780296
158Hypobetalipoproteinemia (HP:0003563)1.79364629
159Generalized hypopigmentation of hair (HP:0011358)1.79257724
160Hyperkalemia (HP:0002153)1.79085584
161Spinal cord compression (HP:0002176)1.78407670
162Papillary thyroid carcinoma (HP:0002895)1.77750868
163Depression (HP:0000716)1.77313902
164Curly hair (HP:0002212)1.76723567
165Bifid tongue (HP:0010297)1.76136952
166Renal tubular acidosis (HP:0001947)1.75313949
167EEG with generalized epileptiform discharges (HP:0011198)1.74717691
168Unilateral renal agenesis (HP:0000122)1.74369534
169Fragile nails (HP:0001808)1.74307978
170Hyperaldosteronism (HP:0000859)1.73433598
171Stereotypic behavior (HP:0000733)1.72135514
172Aqueductal stenosis (HP:0002410)1.72070396
173Oligodontia (HP:0000677)1.70946057
174Corneal erosion (HP:0200020)1.69790642
175Abdominal distention (HP:0003270)1.67973788
176Flattened epiphyses (HP:0003071)1.67951430
177Vertebral arch anomaly (HP:0008438)1.67948355
178Subcapsular cataract (HP:0000523)1.67610154
179Polar cataract (HP:0010696)1.66029174
180Abnormal pancreas size (HP:0012094)1.64444375
181Trismus (HP:0000211)1.63084556
182Acanthosis nigricans (HP:0000956)1.62531068
183Osteolytic defects of the hand bones (HP:0009699)1.61571553

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.69995713
2EPHA45.12564774
3FRK4.26814288
4NTRK33.75077813
5MAP3K123.54882315
6MET3.23461567
7DAPK23.05068529
8RIPK42.90522397
9MAP3K92.85566510
10LMTK22.68378232
11CDK122.57666878
12SIK12.36728617
13MAP3K42.26304644
14PLK22.25728199
15MINK12.24812282
16MAP2K72.24502835
17CASK2.09126555
18DAPK12.01578165
19MAP3K21.96286047
20KSR21.95789450
21TRIB31.92680704
22LATS11.87301197
23MAP2K41.80201508
24SCYL21.75795559
25EIF2AK11.66931739
26PAK41.64594194
27NME11.63535835
28KSR11.62049511
29GRK51.61431806
30RIPK11.51720303
31STK38L1.50006595
32BRSK21.47924850
33BMPR21.43336123
34ARAF1.42347268
35RPS6KB21.42176800
36PBK1.41353407
37NTRK11.39880688
38PTK2B1.34189101
39BCR1.27713840
40IRAK31.24600114
41SGK21.24527395
42FER1.24371279
43BRSK11.21927635
44TRIM281.17930434
45SMG11.13034335
46OXSR11.10619055
47SGK2231.09252939
48SGK4941.09252939
49MST41.07452185
50PRKCG1.07265496
51PKN21.06851781
52CDK51.06254026
53ERBB31.04993161
54CAMK2A1.03500585
55PIK3CA1.02059315
56CAMK2B1.01948685
57MARK11.01559413
58MAP2K10.99696973
59AKT30.97008725
60SIK30.96497965
61ERBB40.95975026
62NME20.95498262
63CAMKK10.94489106
64MST1R0.93218048
65MAPKAPK30.91962318
66SGK30.90400952
67PAK60.88136818
68MAP3K130.87474433
69NEK60.86735157
70EPHB20.83583986
71PRKG20.78734283
72EIF2AK30.78057654
73MAP3K10.76765189
74TTK0.75381177
75ICK0.74866117
76STK30.72856912
77PRKD30.72380115
78EEF2K0.72322485
79PDGFRA0.71201606
80MAP3K30.70936413
81PRKCE0.70447966
82PTK60.70032470
83FGFR10.69778721
84CDK190.69745086
85FGR0.69568146
86FGFR20.69078420
87SIK20.69004596
88PNCK0.67170319
89FGFR40.66517025
90MYLK0.65879613
91PDK40.64794792
92PDK30.64794792
93PRPF4B0.63825933
94PLK30.63470444
95SGK10.63406362
96CDK80.62104870
97RAF10.61014466
98CDK70.58669636
99TSSK60.57887740
100BMX0.57420307
101DMPK0.57405987
102MAPK130.57325194
103GRK60.55549282
104MATK0.54915743
105LRRK20.54708907
106ILK0.53722305
107CAMK2G0.53405251
108EPHB10.53171294
109PRKCZ0.52894234
110NTRK20.52806009
111YES10.52704597
112STK380.51365701
113MTOR0.49675811
114CAMK2D0.49481423
115PAK30.48325486
116NEK10.47028718
117RPS6KA40.45755013
118ERBB20.45358726
119PDPK10.44938525
120MARK30.44465156
121CAMK10.44145447
122FES0.43703400
123CDK140.42381073
124PRKCH0.41838991
125TESK10.41106984
126RET0.39685714
127CDK180.39360085
128TAOK10.39142514
129LATS20.37248309
130MAP3K100.36728558
131DYRK1A0.35483283
132MELK0.35380017
133PDK10.34555365
134LIMK10.34526418
135STK390.34383301
136CSNK1G20.34141902
137MAP3K70.32861542
138WNK40.32717539
139TAF10.32244630
140MAP2K60.31912159
141PRKCA0.31181201
142AKT20.31080620
143PDGFRB0.30865855
144FYN0.30576723
145PRKACA0.30507218
146PTK20.30353617
147ERN10.30281025
148RPS6KB10.30166870
149DAPK30.29573760
150IRAK20.29527912
151PRKCQ0.29502023
152CDK150.29429399
153PRKCI0.28413578
154CCNB10.28372094
155STK240.28113258
156EIF2AK20.27910521
157ROCK20.27540086
158CSNK1E0.27232677
159FGFR30.24905140
160PHKG10.24502175
161PHKG20.24502175

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.29641053
2Long-term potentiation_Homo sapiens_hsa047202.63125630
3Synaptic vesicle cycle_Homo sapiens_hsa047212.58979055
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.31153788
5Adherens junction_Homo sapiens_hsa045202.30296792
6Thyroid cancer_Homo sapiens_hsa052162.30241359
7Amphetamine addiction_Homo sapiens_hsa050312.26078912
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.20380260
9Salivary secretion_Homo sapiens_hsa049702.13232914
10Circadian entrainment_Homo sapiens_hsa047132.11649281
11Glutamatergic synapse_Homo sapiens_hsa047242.03528639
12GABAergic synapse_Homo sapiens_hsa047272.03524918
13Collecting duct acid secretion_Homo sapiens_hsa049661.93743342
14Olfactory transduction_Homo sapiens_hsa047401.87772784
15Vitamin B6 metabolism_Homo sapiens_hsa007501.87481924
16Morphine addiction_Homo sapiens_hsa050321.86040013
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81400096
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.81217192
19Gastric acid secretion_Homo sapiens_hsa049711.80519746
20Taste transduction_Homo sapiens_hsa047421.78033432
21Renin secretion_Homo sapiens_hsa049241.77119181
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.75830317
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.71466457
24Dopaminergic synapse_Homo sapiens_hsa047281.70153276
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.61884779
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.60797949
27Insulin secretion_Homo sapiens_hsa049111.52791793
28Vibrio cholerae infection_Homo sapiens_hsa051101.46130416
29Sphingolipid metabolism_Homo sapiens_hsa006001.45945360
30Tyrosine metabolism_Homo sapiens_hsa003501.39131254
31Starch and sucrose metabolism_Homo sapiens_hsa005001.36918632
32Serotonergic synapse_Homo sapiens_hsa047261.36678283
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33459354
34Long-term depression_Homo sapiens_hsa047301.32595904
35Circadian rhythm_Homo sapiens_hsa047101.31679986
36Calcium signaling pathway_Homo sapiens_hsa040201.31290762
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.29766589
38Hippo signaling pathway_Homo sapiens_hsa043901.28745719
39Bile secretion_Homo sapiens_hsa049761.27241155
40Retinol metabolism_Homo sapiens_hsa008301.25410943
41Fructose and mannose metabolism_Homo sapiens_hsa000511.23195606
42Sulfur metabolism_Homo sapiens_hsa009201.22292275
43Oxytocin signaling pathway_Homo sapiens_hsa049211.22135325
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.21582104
45Endometrial cancer_Homo sapiens_hsa052131.21408209
46Cholinergic synapse_Homo sapiens_hsa047251.20578614
47Nitrogen metabolism_Homo sapiens_hsa009101.19582985
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16643633
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16310534
50beta-Alanine metabolism_Homo sapiens_hsa004101.16263315
51Central carbon metabolism in cancer_Homo sapiens_hsa052301.15184222
52GnRH signaling pathway_Homo sapiens_hsa049121.15063021
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.13329935
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.10494645
55Gap junction_Homo sapiens_hsa045401.09929675
56Cocaine addiction_Homo sapiens_hsa050301.08868881
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.05479847
58Bladder cancer_Homo sapiens_hsa052191.05468512
59Melanogenesis_Homo sapiens_hsa049161.04510475
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04484802
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04061348
62N-Glycan biosynthesis_Homo sapiens_hsa005101.03676285
63Glutathione metabolism_Homo sapiens_hsa004801.02969112
64Arginine biosynthesis_Homo sapiens_hsa002201.01733953
65Arginine and proline metabolism_Homo sapiens_hsa003301.01435097
66Renal cell carcinoma_Homo sapiens_hsa052110.99427556
67Thyroid hormone synthesis_Homo sapiens_hsa049180.97428232
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95744738
69Axon guidance_Homo sapiens_hsa043600.95688414
70Fatty acid biosynthesis_Homo sapiens_hsa000610.94503287
71Mineral absorption_Homo sapiens_hsa049780.93063763
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92332537
73Proteoglycans in cancer_Homo sapiens_hsa052050.92280143
74Oxidative phosphorylation_Homo sapiens_hsa001900.91819165
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91780446
76Alzheimers disease_Homo sapiens_hsa050100.91478323
77Butanoate metabolism_Homo sapiens_hsa006500.90261548
78cAMP signaling pathway_Homo sapiens_hsa040240.88537370
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88478474
80Pancreatic secretion_Homo sapiens_hsa049720.87356682
81Insulin signaling pathway_Homo sapiens_hsa049100.86489613
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86211635
83AMPK signaling pathway_Homo sapiens_hsa041520.84719112
84Vitamin digestion and absorption_Homo sapiens_hsa049770.84098926
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83251967
86Biosynthesis of amino acids_Homo sapiens_hsa012300.82838558
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81566160
88Pancreatic cancer_Homo sapiens_hsa052120.81324119
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80408638
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.79888581
91Glioma_Homo sapiens_hsa052140.78236125
92Insulin resistance_Homo sapiens_hsa049310.78205957
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77601072
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77570088
95Estrogen signaling pathway_Homo sapiens_hsa049150.77421829
96Hepatitis C_Homo sapiens_hsa051600.77353686
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76991802
98Carbon metabolism_Homo sapiens_hsa012000.75935390
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74133579
100Galactose metabolism_Homo sapiens_hsa000520.73847832
101Prostate cancer_Homo sapiens_hsa052150.73671356
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.72969583
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.72066543
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71766509
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71639954
106Propanoate metabolism_Homo sapiens_hsa006400.71206803
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70403419
108Pentose phosphate pathway_Homo sapiens_hsa000300.70249292
109Pyruvate metabolism_Homo sapiens_hsa006200.69887861
110Cardiac muscle contraction_Homo sapiens_hsa042600.68978747
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66993023
112Tryptophan metabolism_Homo sapiens_hsa003800.65335718
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64967624
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64573646
115Tight junction_Homo sapiens_hsa045300.64023693
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.63964713
117African trypanosomiasis_Homo sapiens_hsa051430.63600921
118Inositol phosphate metabolism_Homo sapiens_hsa005620.63507748
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62128505
120TGF-beta signaling pathway_Homo sapiens_hsa043500.62024514
121ErbB signaling pathway_Homo sapiens_hsa040120.61728313
122Phenylalanine metabolism_Homo sapiens_hsa003600.61384594
123Steroid biosynthesis_Homo sapiens_hsa001000.61290735
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61189732
125Wnt signaling pathway_Homo sapiens_hsa043100.61155485
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59681483
127Chemical carcinogenesis_Homo sapiens_hsa052040.59059747
128Glucagon signaling pathway_Homo sapiens_hsa049220.58887351
129ECM-receptor interaction_Homo sapiens_hsa045120.58590118
130Oocyte meiosis_Homo sapiens_hsa041140.58516449
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56788808
132Complement and coagulation cascades_Homo sapiens_hsa046100.53293599
133Focal adhesion_Homo sapiens_hsa045100.51872680
134Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51664104
135Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49194797
136Type II diabetes mellitus_Homo sapiens_hsa049300.48896312
137Non-small cell lung cancer_Homo sapiens_hsa052230.48814974
138Fatty acid degradation_Homo sapiens_hsa000710.48757144
139Peroxisome_Homo sapiens_hsa041460.47569325
140PPAR signaling pathway_Homo sapiens_hsa033200.47158164
141Folate biosynthesis_Homo sapiens_hsa007900.47083393
142Histidine metabolism_Homo sapiens_hsa003400.46243788
143Endocytosis_Homo sapiens_hsa041440.45927457
144Parkinsons disease_Homo sapiens_hsa050120.45730273
145VEGF signaling pathway_Homo sapiens_hsa043700.45061711
146Rap1 signaling pathway_Homo sapiens_hsa040150.42663234
147Phototransduction_Homo sapiens_hsa047440.42650860
148Chronic myeloid leukemia_Homo sapiens_hsa052200.42077621
149mRNA surveillance pathway_Homo sapiens_hsa030150.41878620
150Choline metabolism in cancer_Homo sapiens_hsa052310.41868856
151Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41742770
152Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40523083
153Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40493672
154Small cell lung cancer_Homo sapiens_hsa052220.40403024
155Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40022440
156Fatty acid metabolism_Homo sapiens_hsa012120.39815236
157Dorso-ventral axis formation_Homo sapiens_hsa043200.35980462
158Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32444954
159Glycerolipid metabolism_Homo sapiens_hsa005610.29401058
160Huntingtons disease_Homo sapiens_hsa050160.29202053
161Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29114971
162Phospholipase D signaling pathway_Homo sapiens_hsa040720.29035856
1632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28924600

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