

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 6.17111391 |
| 2 | viral transcription (GO:0019083) | 5.88281364 |
| 3 | translational termination (GO:0006415) | 5.81028530 |
| 4 | chaperone-mediated protein transport (GO:0072321) | 5.63606522 |
| 5 | maturation of SSU-rRNA (GO:0030490) | 5.50420386 |
| 6 | ribosomal small subunit biogenesis (GO:0042274) | 5.43691055 |
| 7 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.27199631 |
| 8 | DNA deamination (GO:0045006) | 5.12440819 |
| 9 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.04579088 |
| 10 | translational elongation (GO:0006414) | 5.03291878 |
| 11 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.93319503 |
| 12 | cotranslational protein targeting to membrane (GO:0006613) | 4.80996681 |
| 13 | protein targeting to ER (GO:0045047) | 4.79296973 |
| 14 | translational initiation (GO:0006413) | 4.77245580 |
| 15 | respiratory electron transport chain (GO:0022904) | 4.74208016 |
| 16 | * ribosomal large subunit biogenesis (GO:0042273) | 4.65020505 |
| 17 | electron transport chain (GO:0022900) | 4.60990610 |
| 18 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.60253136 |
| 19 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.52997030 |
| 20 | cellular protein complex disassembly (GO:0043624) | 4.50546681 |
| 21 | protein localization to endoplasmic reticulum (GO:0070972) | 4.50034534 |
| 22 | viral life cycle (GO:0019058) | 4.43482623 |
| 23 | protein complex biogenesis (GO:0070271) | 4.17075431 |
| 24 | formation of translation preinitiation complex (GO:0001731) | 4.08975820 |
| 25 | translation (GO:0006412) | 4.07293355 |
| 26 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.03389005 |
| 27 | kinetochore organization (GO:0051383) | 4.00160511 |
| 28 | kinetochore assembly (GO:0051382) | 3.96601683 |
| 29 | protein complex disassembly (GO:0043241) | 3.96110683 |
| 30 | * regulation of mitochondrial translation (GO:0070129) | 3.96003394 |
| 31 | * ribonucleoprotein complex biogenesis (GO:0022613) | 3.95184392 |
| 32 | proteasome assembly (GO:0043248) | 3.91885957 |
| 33 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.86949501 |
| 34 | CENP-A containing nucleosome assembly (GO:0034080) | 3.82775132 |
| 35 | macromolecular complex disassembly (GO:0032984) | 3.81806506 |
| 36 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.80727269 |
| 37 | protein targeting to mitochondrion (GO:0006626) | 3.76258420 |
| 38 | chromatin remodeling at centromere (GO:0031055) | 3.75204897 |
| 39 | mitotic metaphase plate congression (GO:0007080) | 3.73249420 |
| 40 | spliceosomal snRNP assembly (GO:0000387) | 3.69764276 |
| 41 | protein neddylation (GO:0045116) | 3.66450151 |
| 42 | DNA strand elongation (GO:0022616) | 3.65042858 |
| 43 | rRNA processing (GO:0006364) | 3.64256299 |
| 44 | purine nucleobase biosynthetic process (GO:0009113) | 3.63940544 |
| 45 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.61035056 |
| 46 | spliceosomal complex assembly (GO:0000245) | 3.59609481 |
| 47 | establishment of protein localization to mitochondrion (GO:0072655) | 3.56798315 |
| 48 | rRNA metabolic process (GO:0016072) | 3.52941720 |
| 49 | rRNA modification (GO:0000154) | 3.49712935 |
| 50 | protein localization to mitochondrion (GO:0070585) | 3.49015423 |
| 51 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.47739952 |
| 52 | termination of RNA polymerase III transcription (GO:0006386) | 3.47739952 |
| 53 | telomere maintenance via recombination (GO:0000722) | 3.46315709 |
| 54 | nucleobase biosynthetic process (GO:0046112) | 3.46079922 |
| 55 | DNA replication initiation (GO:0006270) | 3.43247579 |
| 56 | respiratory chain complex IV assembly (GO:0008535) | 3.42895904 |
| 57 | DNA damage response, detection of DNA damage (GO:0042769) | 3.42805482 |
| 58 | mRNA catabolic process (GO:0006402) | 3.40471233 |
| 59 | * cellular component biogenesis (GO:0044085) | 3.36438381 |
| 60 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.36023361 |
| 61 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.35256273 |
| 62 | DNA replication-independent nucleosome organization (GO:0034724) | 3.35256273 |
| 63 | metaphase plate congression (GO:0051310) | 3.35243903 |
| 64 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.33258148 |
| 65 | pseudouridine synthesis (GO:0001522) | 3.32687589 |
| 66 | DNA replication checkpoint (GO:0000076) | 3.31042471 |
| 67 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.29110929 |
| 68 | mitotic recombination (GO:0006312) | 3.27031761 |
| 69 | ATP synthesis coupled proton transport (GO:0015986) | 3.26205617 |
| 70 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.26205617 |
| 71 | RNA catabolic process (GO:0006401) | 3.24706020 |
| 72 | ribosome assembly (GO:0042255) | 3.22232665 |
| 73 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.22137606 |
| 74 | inner mitochondrial membrane organization (GO:0007007) | 3.20958185 |
| 75 | ribosome biogenesis (GO:0042254) | 3.18866958 |
| 76 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.17241458 |
| 77 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.15655040 |
| 78 | cytochrome complex assembly (GO:0017004) | 3.15409020 |
| 79 | oxidative phosphorylation (GO:0006119) | 3.14745893 |
| 80 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.14446744 |
| 81 | viral mRNA export from host cell nucleus (GO:0046784) | 3.14395600 |
| 82 | telomere maintenance via telomere lengthening (GO:0010833) | 3.12000823 |
| 83 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.11357700 |
| 84 | histone exchange (GO:0043486) | 3.10066546 |
| 85 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.05778572 |
| 86 | establishment of viral latency (GO:0019043) | 3.04942189 |
| 87 | DNA unwinding involved in DNA replication (GO:0006268) | 3.03919120 |
| 88 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.02890814 |
| 89 | NADH dehydrogenase complex assembly (GO:0010257) | 3.02890814 |
| 90 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.02890814 |
| 91 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.02079668 |
| 92 | establishment of integrated proviral latency (GO:0075713) | 2.99960121 |
| 93 | protein targeting to membrane (GO:0006612) | 2.99707245 |
| 94 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 2.96139646 |
| 95 | ATP biosynthetic process (GO:0006754) | 2.94146133 |
| 96 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.93918792 |
| 97 | negative regulation of ligase activity (GO:0051352) | 2.93918792 |
| 98 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.91828029 |
| 99 | 7-methylguanosine mRNA capping (GO:0006370) | 2.91623247 |
| 100 | protein deneddylation (GO:0000338) | 2.91087815 |
| 101 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.90478460 |
| 102 | mitochondrial transport (GO:0006839) | 2.89467170 |
| 103 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.89215223 |
| 104 | establishment of chromosome localization (GO:0051303) | 2.89154520 |
| 105 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 2.88563340 |
| 106 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.88480190 |
| 107 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.88480190 |
| 108 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.87446326 |
| 109 | cullin deneddylation (GO:0010388) | 2.87093184 |
| 110 | 7-methylguanosine RNA capping (GO:0009452) | 2.86894746 |
| 111 | RNA capping (GO:0036260) | 2.86894746 |
| 112 | GTP biosynthetic process (GO:0006183) | 2.86873122 |
| 113 | intracellular protein transmembrane import (GO:0044743) | 2.86697363 |
| 114 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.86088342 |
| 115 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.85525592 |
| 116 | peptidyl-histidine modification (GO:0018202) | 2.84187757 |
| 117 | DNA replication-dependent nucleosome assembly (GO:0006335) | 2.83869320 |
| 118 | DNA replication-dependent nucleosome organization (GO:0034723) | 2.83869320 |
| 119 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.83173313 |
| 120 | termination of RNA polymerase I transcription (GO:0006363) | 2.82872517 |
| 121 | positive regulation of ligase activity (GO:0051351) | 2.82743563 |
| 122 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.82658393 |
| 123 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.82094889 |
| 124 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.82094889 |
| 125 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.82094889 |
| 126 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.81786103 |
| 127 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.81786103 |
| 128 | ncRNA processing (GO:0034470) | 2.79747500 |
| 129 | transcription from RNA polymerase I promoter (GO:0006360) | 2.79272689 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.78552934 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.78909753 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.00392010 |
| 4 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.64950730 |
| 5 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.43837223 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.41787310 |
| 7 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.36498780 |
| 8 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.25869294 |
| 9 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.24341452 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.23971620 |
| 11 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.21615285 |
| 12 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.11841108 |
| 13 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.07331126 |
| 14 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 3.01758127 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.95063007 |
| 16 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.82204677 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.74266843 |
| 18 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.71040183 |
| 19 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.58772525 |
| 20 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.51096651 |
| 21 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.50531630 |
| 22 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.47444522 |
| 23 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.40641122 |
| 24 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.36668648 |
| 25 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.35670229 |
| 26 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.32721441 |
| 27 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.20124070 |
| 28 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.18369069 |
| 29 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.13973924 |
| 30 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.10993714 |
| 31 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.10206316 |
| 32 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.01309742 |
| 33 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.00416040 |
| 34 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.95159750 |
| 35 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.93298769 |
| 36 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.89523713 |
| 37 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.86901442 |
| 38 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.84206552 |
| 39 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.78832222 |
| 40 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.78811562 |
| 41 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.76320113 |
| 42 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.74475489 |
| 43 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.73667610 |
| 44 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.72225831 |
| 45 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.71439229 |
| 46 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.70083992 |
| 47 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.68809626 |
| 48 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.68563480 |
| 49 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.67953272 |
| 50 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.67167907 |
| 51 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.62456859 |
| 52 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.55517463 |
| 53 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.53034898 |
| 54 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.50365204 |
| 55 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.47898186 |
| 56 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.47199381 |
| 57 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.37781029 |
| 58 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.36912017 |
| 59 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.36622213 |
| 60 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.33494187 |
| 61 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.29219401 |
| 62 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.28921532 |
| 63 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.28199952 |
| 64 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.25986737 |
| 65 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.25879298 |
| 66 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.25197774 |
| 67 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.25104723 |
| 68 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.24483044 |
| 69 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.23744206 |
| 70 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.22804783 |
| 71 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.16126479 |
| 72 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.15607467 |
| 73 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.15452724 |
| 74 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.13971637 |
| 75 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.12468242 |
| 76 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.11723422 |
| 77 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.10328815 |
| 78 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.08649766 |
| 79 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.07683991 |
| 80 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.07022045 |
| 81 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.06109980 |
| 82 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.05580693 |
| 83 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.01611373 |
| 84 | EWS_26573619_Chip-Seq_HEK293_Human | 1.00765082 |
| 85 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.98825838 |
| 86 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.96774088 |
| 87 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.96162899 |
| 88 | FUS_26573619_Chip-Seq_HEK293_Human | 0.96047749 |
| 89 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.95788573 |
| 90 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.95681178 |
| 91 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.93291199 |
| 92 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.93117096 |
| 93 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.92582320 |
| 94 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.92314911 |
| 95 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.91986943 |
| 96 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.90873906 |
| 97 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.89717419 |
| 98 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.89655051 |
| 99 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.89501081 |
| 100 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.86245298 |
| 101 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.85371705 |
| 102 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.84865604 |
| 103 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.83276972 |
| 104 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.82881725 |
| 105 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 0.82708993 |
| 106 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.82317206 |
| 107 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.82044618 |
| 108 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.81324778 |
| 109 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.81131493 |
| 110 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.80411090 |
| 111 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.79851077 |
| 112 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.78354944 |
| 113 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.77135614 |
| 114 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 0.74138492 |
| 115 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.73666445 |
| 116 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.73069636 |
| 117 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.65977947 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.53469867 |
| 2 | MP0009379_abnormal_foot_pigmentation | 3.97721968 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 3.96097226 |
| 4 | MP0003111_abnormal_nucleus_morphology | 3.68537887 |
| 5 | MP0010094_abnormal_chromosome_stability | 3.68330826 |
| 6 | MP0003077_abnormal_cell_cycle | 3.45569259 |
| 7 | MP0008058_abnormal_DNA_repair | 3.00047716 |
| 8 | MP0008057_abnormal_DNA_replication | 2.61279848 |
| 9 | MP0008007_abnormal_cellular_replicative | 2.48195231 |
| 10 | MP0008932_abnormal_embryonic_tissue | 2.48068730 |
| 11 | MP0003123_paternal_imprinting | 2.32698691 |
| 12 | MP0010030_abnormal_orbit_morphology | 1.87750968 |
| 13 | MP0002234_abnormal_pharynx_morphology | 1.86825288 |
| 14 | MP0003315_abnormal_perineum_morphology | 1.86435908 |
| 15 | MP0003186_abnormal_redox_activity | 1.84925015 |
| 16 | MP0001529_abnormal_vocalization | 1.83949912 |
| 17 | MP0003786_premature_aging | 1.80225081 |
| 18 | MP0003567_abnormal_fetal_cardiomyocyte | 1.78930190 |
| 19 | MP0009053_abnormal_anal_canal | 1.71629861 |
| 20 | MP0001730_embryonic_growth_arrest | 1.71473809 |
| 21 | MP0003718_maternal_effect | 1.68271640 |
| 22 | MP0000350_abnormal_cell_proliferation | 1.65830821 |
| 23 | MP0003806_abnormal_nucleotide_metabolis | 1.52423071 |
| 24 | MP0001293_anophthalmia | 1.52194656 |
| 25 | MP0008877_abnormal_DNA_methylation | 1.48311861 |
| 26 | MP0006036_abnormal_mitochondrial_physio | 1.46098855 |
| 27 | MP0006292_abnormal_olfactory_placode | 1.45550864 |
| 28 | MP0001697_abnormal_embryo_size | 1.45531716 |
| 29 | MP0000490_abnormal_crypts_of | 1.45181177 |
| 30 | MP0002396_abnormal_hematopoietic_system | 1.44731538 |
| 31 | MP0003941_abnormal_skin_development | 1.41077644 |
| 32 | MP0002132_abnormal_respiratory_system | 1.40504674 |
| 33 | MP0005380_embryogenesis_phenotype | 1.40037451 |
| 34 | MP0001672_abnormal_embryogenesis/_devel | 1.40037451 |
| 35 | MP0000313_abnormal_cell_death | 1.38314775 |
| 36 | MP0002837_dystrophic_cardiac_calcinosis | 1.30990534 |
| 37 | MP0002233_abnormal_nose_morphology | 1.30256049 |
| 38 | MP0003119_abnormal_digestive_system | 1.27825854 |
| 39 | MP0003890_abnormal_embryonic-extraembry | 1.26517407 |
| 40 | MP0003984_embryonic_growth_retardation | 1.25052199 |
| 41 | MP0002088_abnormal_embryonic_growth/wei | 1.24733939 |
| 42 | MP0005499_abnormal_olfactory_system | 1.24006479 |
| 43 | MP0005394_taste/olfaction_phenotype | 1.24006479 |
| 44 | MP0002085_abnormal_embryonic_tissue | 1.21438512 |
| 45 | MP0000049_abnormal_middle_ear | 1.20581216 |
| 46 | MP0002697_abnormal_eye_size | 1.18465412 |
| 47 | MP0002080_prenatal_lethality | 1.18338451 |
| 48 | MP0002102_abnormal_ear_morphology | 1.18220608 |
| 49 | MP0000631_abnormal_neuroendocrine_gland | 1.16737739 |
| 50 | MP0009697_abnormal_copulation | 1.16717000 |
| 51 | MP0006072_abnormal_retinal_apoptosis | 1.14461736 |
| 52 | MP0004133_heterotaxia | 1.13883036 |
| 53 | MP0001188_hyperpigmentation | 1.13609680 |
| 54 | MP0006035_abnormal_mitochondrial_morpho | 1.13078738 |
| 55 | MP0002210_abnormal_sex_determination | 1.12879932 |
| 56 | MP0000537_abnormal_urethra_morphology | 1.09567461 |
| 57 | MP0003011_delayed_dark_adaptation | 1.08491786 |
| 58 | MP0002160_abnormal_reproductive_system | 1.07869716 |
| 59 | MP0000566_synostosis | 1.06730949 |
| 60 | MP0001764_abnormal_homeostasis | 1.06309758 |
| 61 | MP0004808_abnormal_hematopoietic_stem | 1.05070187 |
| 62 | MP0004197_abnormal_fetal_growth/weight/ | 1.04509482 |
| 63 | MP0004142_abnormal_muscle_tone | 1.04120150 |
| 64 | MP0002938_white_spotting | 1.04047745 |
| 65 | MP0002019_abnormal_tumor_incidence | 1.02101310 |
| 66 | MP0000750_abnormal_muscle_regeneration | 1.02009399 |
| 67 | MP0002086_abnormal_extraembryonic_tissu | 1.01897056 |
| 68 | MP0003121_genomic_imprinting | 0.99644002 |
| 69 | MP0005389_reproductive_system_phenotype | 0.99404503 |
| 70 | MP0005174_abnormal_tail_pigmentation | 0.98107708 |
| 71 | MP0002736_abnormal_nociception_after | 0.97381571 |
| 72 | MP0002638_abnormal_pupillary_reflex | 0.95307635 |
| 73 | MP0002095_abnormal_skin_pigmentation | 0.92781944 |
| 74 | MP0001286_abnormal_eye_development | 0.92502232 |
| 75 | MP0001485_abnormal_pinna_reflex | 0.92281987 |
| 76 | MP0001853_heart_inflammation | 0.91726057 |
| 77 | MP0001145_abnormal_male_reproductive | 0.91417434 |
| 78 | MP0010352_gastrointestinal_tract_polyps | 0.90766706 |
| 79 | MP0002084_abnormal_developmental_patter | 0.90438778 |
| 80 | MP0003136_yellow_coat_color | 0.90334772 |
| 81 | MP0004233_abnormal_muscle_weight | 0.89543441 |
| 82 | MP0003755_abnormal_palate_morphology | 0.88741475 |
| 83 | MP0001119_abnormal_female_reproductive | 0.88274008 |
| 84 | MP0001919_abnormal_reproductive_system | 0.88117465 |
| 85 | MP0003938_abnormal_ear_development | 0.87218688 |
| 86 | MP0000358_abnormal_cell_content/ | 0.86649763 |
| 87 | MP0002163_abnormal_gland_morphology | 0.86539528 |
| 88 | MP0005075_abnormal_melanosome_morpholog | 0.86520949 |
| 89 | MP0005367_renal/urinary_system_phenotyp | 0.85226727 |
| 90 | MP0000516_abnormal_urinary_system | 0.85226727 |
| 91 | MP0009333_abnormal_splenocyte_physiolog | 0.84901612 |
| 92 | MP0002111_abnormal_tail_morphology | 0.84877721 |
| 93 | MP0003221_abnormal_cardiomyocyte_apopto | 0.83722525 |
| 94 | MP0003698_abnormal_male_reproductive | 0.80973736 |
| 95 | MP0003646_muscle_fatigue | 0.80715675 |
| 96 | MP0000858_altered_metastatic_potential | 0.80161109 |
| 97 | MP0005410_abnormal_fertilization | 0.79815576 |
| 98 | MP0000653_abnormal_sex_gland | 0.79315961 |
| 99 | MP0009250_abnormal_appendicular_skeleto | 0.76911391 |
| 100 | MP0001905_abnormal_dopamine_level | 0.76224049 |
| 101 | MP0000703_abnormal_thymus_morphology | 0.75218159 |
| 102 | MP0000015_abnormal_ear_pigmentation | 0.74045803 |
| 103 | MP0002277_abnormal_respiratory_mucosa | 0.73938873 |
| 104 | MP0000647_abnormal_sebaceous_gland | 0.73900588 |
| 105 | MP0009672_abnormal_birth_weight | 0.70839648 |
| 106 | MP0008789_abnormal_olfactory_epithelium | 0.70001905 |
| 107 | MP0002653_abnormal_ependyma_morphology | 0.69803201 |
| 108 | MP0005187_abnormal_penis_morphology | 0.69255687 |
| 109 | MP0001984_abnormal_olfaction | 0.68208058 |
| 110 | MP0003878_abnormal_ear_physiology | 0.68003398 |
| 111 | MP0005377_hearing/vestibular/ear_phenot | 0.68003398 |
| 112 | MP0003861_abnormal_nervous_system | 0.67671585 |
| 113 | MP0000749_muscle_degeneration | 0.66736092 |
| 114 | MP0002751_abnormal_autonomic_nervous | 0.66414066 |
| 115 | MP0003937_abnormal_limbs/digits/tail_de | 0.65423167 |
| 116 | MP0000372_irregular_coat_pigmentation | 0.65161760 |
| 117 | MP0002161_abnormal_fertility/fecundity | 0.64964083 |
| 118 | MP0006276_abnormal_autonomic_nervous | 0.64842010 |
| 119 | MP0003942_abnormal_urinary_system | 0.64799520 |
| 120 | MP0003122_maternal_imprinting | 0.64785224 |
| 121 | MP0005408_hypopigmentation | 0.63817775 |
| 122 | MP0001929_abnormal_gametogenesis | 0.63544538 |
| 123 | MP0005084_abnormal_gallbladder_morpholo | 0.63022701 |
| 124 | MP0002092_abnormal_eye_morphology | 0.62844090 |
| 125 | MP0002722_abnormal_immune_system | 0.60408731 |
| 126 | MP0003828_pulmonary_edema | 0.60272770 |
| 127 | MP0003763_abnormal_thymus_physiology | 0.60246352 |
| 128 | MP0000762_abnormal_tongue_morphology | 0.59411313 |
| 129 | MP0003385_abnormal_body_wall | 0.58695418 |
| 130 | MP0000432_abnormal_head_morphology | 0.56914788 |
| 131 | MP0003936_abnormal_reproductive_system | 0.56412559 |
| 132 | MP0004381_abnormal_hair_follicle | 0.56258219 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Reticulocytopenia (HP:0001896) | 6.05961185 |
| 2 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.91832832 |
| 3 | Abnormal number of erythroid precursors (HP:0012131) | 4.65060668 |
| 4 | Increased hepatocellular lipid droplets (HP:0006565) | 4.10413699 |
| 5 | Macrocytic anemia (HP:0001972) | 3.99884829 |
| 6 | Colon cancer (HP:0003003) | 3.89225661 |
| 7 | Mitochondrial inheritance (HP:0001427) | 3.87044668 |
| 8 | Acute necrotizing encephalopathy (HP:0006965) | 3.86791098 |
| 9 | Lipid accumulation in hepatocytes (HP:0006561) | 3.86673783 |
| 10 | Pallor (HP:0000980) | 3.79140275 |
| 11 | Increased CSF lactate (HP:0002490) | 3.61040248 |
| 12 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.60442188 |
| 13 | Hepatocellular necrosis (HP:0001404) | 3.47464932 |
| 14 | Chromsome breakage (HP:0040012) | 3.44252226 |
| 15 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.41876340 |
| 16 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.37159569 |
| 17 | Birth length less than 3rd percentile (HP:0003561) | 3.35365814 |
| 18 | Hepatic necrosis (HP:0002605) | 3.32669125 |
| 19 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.24427459 |
| 20 | Progressive macrocephaly (HP:0004481) | 3.21696588 |
| 21 | Acute encephalopathy (HP:0006846) | 3.15640323 |
| 22 | Breast hypoplasia (HP:0003187) | 3.04169963 |
| 23 | Exertional dyspnea (HP:0002875) | 3.03530931 |
| 24 | Increased serum lactate (HP:0002151) | 3.01904927 |
| 25 | Microvesicular hepatic steatosis (HP:0001414) | 2.99437481 |
| 26 | Oral leukoplakia (HP:0002745) | 2.99142448 |
| 27 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.93752697 |
| 28 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.93752697 |
| 29 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.91516509 |
| 30 | Absent thumb (HP:0009777) | 2.86863861 |
| 31 | Abnormal hemoglobin (HP:0011902) | 2.84272621 |
| 32 | Respiratory difficulties (HP:0002880) | 2.78438366 |
| 33 | Abnormality of alanine metabolism (HP:0010916) | 2.74231116 |
| 34 | Hyperalaninemia (HP:0003348) | 2.74231116 |
| 35 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.74231116 |
| 36 | Meckel diverticulum (HP:0002245) | 2.71812918 |
| 37 | Microretrognathia (HP:0000308) | 2.71660222 |
| 38 | Abnormality of the preputium (HP:0100587) | 2.70153510 |
| 39 | Septo-optic dysplasia (HP:0100842) | 2.69007523 |
| 40 | Trismus (HP:0000211) | 2.66095592 |
| 41 | Exercise intolerance (HP:0003546) | 2.63126666 |
| 42 | Renal Fanconi syndrome (HP:0001994) | 2.62732087 |
| 43 | Abnormality of the ileum (HP:0001549) | 2.56717482 |
| 44 | Leukodystrophy (HP:0002415) | 2.54688434 |
| 45 | Abnormality of glycolysis (HP:0004366) | 2.54299246 |
| 46 | Increased serum pyruvate (HP:0003542) | 2.54299246 |
| 47 | Aplastic anemia (HP:0001915) | 2.52975893 |
| 48 | Triphalangeal thumb (HP:0001199) | 2.51842823 |
| 49 | Patellar aplasia (HP:0006443) | 2.50838322 |
| 50 | Increased intramyocellular lipid droplets (HP:0012240) | 2.47511843 |
| 51 | Hyperglycinemia (HP:0002154) | 2.46572831 |
| 52 | Degeneration of anterior horn cells (HP:0002398) | 2.44540179 |
| 53 | Abnormality of the anterior horn cell (HP:0006802) | 2.44540179 |
| 54 | Cerebral edema (HP:0002181) | 2.41302369 |
| 55 | Rough bone trabeculation (HP:0100670) | 2.39110652 |
| 56 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.39040579 |
| 57 | Lactic acidosis (HP:0003128) | 2.36921159 |
| 58 | Abnormality of chromosome stability (HP:0003220) | 2.35844977 |
| 59 | Horseshoe kidney (HP:0000085) | 2.34308736 |
| 60 | 11 pairs of ribs (HP:0000878) | 2.33823003 |
| 61 | 3-Methylglutaconic aciduria (HP:0003535) | 2.30411840 |
| 62 | Cleft eyelid (HP:0000625) | 2.28277182 |
| 63 | Carpal bone hypoplasia (HP:0001498) | 2.26665506 |
| 64 | Absent radius (HP:0003974) | 2.26058536 |
| 65 | Secondary amenorrhea (HP:0000869) | 2.25473425 |
| 66 | Optic disc pallor (HP:0000543) | 2.24794358 |
| 67 | Increased muscle lipid content (HP:0009058) | 2.24302978 |
| 68 | Lethargy (HP:0001254) | 2.23713361 |
| 69 | Abnormality of renal resorption (HP:0011038) | 2.23707953 |
| 70 | Multiple enchondromatosis (HP:0005701) | 2.23006062 |
| 71 | Respiratory failure (HP:0002878) | 2.20754484 |
| 72 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.18755389 |
| 73 | Congenital, generalized hypertrichosis (HP:0004540) | 2.18274128 |
| 74 | Neoplasm of the colon (HP:0100273) | 2.15988764 |
| 75 | Neoplasm of the pancreas (HP:0002894) | 2.15630735 |
| 76 | Nemaline bodies (HP:0003798) | 2.15355321 |
| 77 | Nausea (HP:0002018) | 2.14142432 |
| 78 | Selective tooth agenesis (HP:0001592) | 2.13886699 |
| 79 | Abnormality of serum amino acid levels (HP:0003112) | 2.13008397 |
| 80 | Abnormality of methionine metabolism (HP:0010901) | 2.11664508 |
| 81 | Abnormal trabecular bone morphology (HP:0100671) | 2.10759835 |
| 82 | Aplasia involving forearm bones (HP:0009822) | 2.07634175 |
| 83 | Absent forearm bone (HP:0003953) | 2.07634175 |
| 84 | Glycosuria (HP:0003076) | 2.07374419 |
| 85 | Abnormality of urine glucose concentration (HP:0011016) | 2.07374419 |
| 86 | Medulloblastoma (HP:0002885) | 2.06512227 |
| 87 | Abnormal lung lobation (HP:0002101) | 2.06488665 |
| 88 | Absent septum pellucidum (HP:0001331) | 2.06217715 |
| 89 | Premature graying of hair (HP:0002216) | 2.05710558 |
| 90 | Facial cleft (HP:0002006) | 2.05333452 |
| 91 | Methylmalonic aciduria (HP:0012120) | 2.04340147 |
| 92 | Biliary tract neoplasm (HP:0100574) | 2.02051064 |
| 93 | Type I transferrin isoform profile (HP:0003642) | 2.01514419 |
| 94 | Methylmalonic acidemia (HP:0002912) | 2.00254282 |
| 95 | Generalized aminoaciduria (HP:0002909) | 1.96263792 |
| 96 | Abnormality of reticulocytes (HP:0004312) | 1.96091311 |
| 97 | X-linked dominant inheritance (HP:0001423) | 1.92143958 |
| 98 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.92031553 |
| 99 | CNS demyelination (HP:0007305) | 1.90728873 |
| 100 | Premature ovarian failure (HP:0008209) | 1.89991509 |
| 101 | Abnormality of the labia minora (HP:0012880) | 1.88388502 |
| 102 | Poor head control (HP:0002421) | 1.87731932 |
| 103 | Agnosia (HP:0010524) | 1.86577445 |
| 104 | Supernumerary spleens (HP:0009799) | 1.85588184 |
| 105 | Intestinal fistula (HP:0100819) | 1.84673094 |
| 106 | Hyperphosphaturia (HP:0003109) | 1.83641028 |
| 107 | Abnormality of placental membranes (HP:0011409) | 1.83377872 |
| 108 | Amniotic constriction ring (HP:0009775) | 1.83377872 |
| 109 | Hypoplasia of the radius (HP:0002984) | 1.82793903 |
| 110 | Stenosis of the external auditory canal (HP:0000402) | 1.81820314 |
| 111 | Maternal diabetes (HP:0009800) | 1.80957122 |
| 112 | Sclerocornea (HP:0000647) | 1.79805764 |
| 113 | Sparse eyelashes (HP:0000653) | 1.79761371 |
| 114 | Abnormal number of incisors (HP:0011064) | 1.79576302 |
| 115 | Myelodysplasia (HP:0002863) | 1.79420316 |
| 116 | Cellular immunodeficiency (HP:0005374) | 1.79246387 |
| 117 | Megaloblastic anemia (HP:0001889) | 1.78856507 |
| 118 | Duplicated collecting system (HP:0000081) | 1.78825135 |
| 119 | Cerebral hypomyelination (HP:0006808) | 1.78755137 |
| 120 | Rectal fistula (HP:0100590) | 1.78558830 |
| 121 | Rectovaginal fistula (HP:0000143) | 1.78558830 |
| 122 | Duodenal stenosis (HP:0100867) | 1.78159599 |
| 123 | Small intestinal stenosis (HP:0012848) | 1.78159599 |
| 124 | Bone marrow hypocellularity (HP:0005528) | 1.77892720 |
| 125 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.77439835 |
| 126 | Pancreatic fibrosis (HP:0100732) | 1.77034151 |
| 127 | Pancytopenia (HP:0001876) | 1.76750634 |
| 128 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.76481182 |
| 129 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.76481182 |
| 130 | Abnormal protein glycosylation (HP:0012346) | 1.76481182 |
| 131 | Abnormal glycosylation (HP:0012345) | 1.76481182 |
| 132 | Reduced antithrombin III activity (HP:0001976) | 1.74281499 |
| 133 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 1.73557160 |
| 134 | Atresia of the external auditory canal (HP:0000413) | 1.72880085 |
| 135 | Anophthalmia (HP:0000528) | 1.71623126 |
| 136 | Partial duplication of thumb phalanx (HP:0009944) | 1.70882861 |
| 137 | Abnormality of the septum pellucidum (HP:0007375) | 1.70644088 |
| 138 | Ectopic kidney (HP:0000086) | 1.66672555 |
| 139 | Median cleft lip (HP:0000161) | 1.65875744 |
| 140 | Pancreatic cysts (HP:0001737) | 1.65227213 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.44773337 |
| 2 | NME2 | 3.99733304 |
| 3 | VRK2 | 3.82234506 |
| 4 | EIF2AK1 | 3.55969237 |
| 5 | WEE1 | 3.51063662 |
| 6 | TLK1 | 3.48335661 |
| 7 | SRPK1 | 3.45835149 |
| 8 | STK16 | 2.43893672 |
| 9 | ACVR1B | 2.42496120 |
| 10 | NEK2 | 2.28432633 |
| 11 | CDC7 | 2.24748213 |
| 12 | ZAK | 2.19884562 |
| 13 | IRAK3 | 2.16445200 |
| 14 | PLK4 | 2.13201821 |
| 15 | DYRK3 | 2.05263653 |
| 16 | RPS6KA4 | 2.02963878 |
| 17 | EIF2AK3 | 2.01541867 |
| 18 | TTK | 1.92507266 |
| 19 | MKNK1 | 1.75650635 |
| 20 | PLK1 | 1.73156973 |
| 21 | PBK | 1.68564431 |
| 22 | AURKB | 1.67182285 |
| 23 | VRK1 | 1.66935464 |
| 24 | NME1 | 1.63956073 |
| 25 | BRSK2 | 1.55309667 |
| 26 | PDK2 | 1.52310212 |
| 27 | CDK7 | 1.49394498 |
| 28 | AURKA | 1.48184532 |
| 29 | MKNK2 | 1.45932197 |
| 30 | CDK19 | 1.42294327 |
| 31 | TESK2 | 1.38701047 |
| 32 | BRAF | 1.38381447 |
| 33 | TNIK | 1.32688241 |
| 34 | PNCK | 1.32096934 |
| 35 | CDK12 | 1.29618475 |
| 36 | WNK4 | 1.28007331 |
| 37 | EIF2AK2 | 1.27387555 |
| 38 | KDR | 1.23541865 |
| 39 | ATR | 1.21656224 |
| 40 | CHEK2 | 1.19737293 |
| 41 | EPHA2 | 1.18251453 |
| 42 | DYRK2 | 1.17216798 |
| 43 | TAF1 | 1.14637614 |
| 44 | NEK9 | 1.12080190 |
| 45 | PIM2 | 1.10741225 |
| 46 | STK39 | 1.08353741 |
| 47 | MAP3K11 | 1.07961844 |
| 48 | BCKDK | 1.05445281 |
| 49 | PASK | 1.04380117 |
| 50 | RPS6KB2 | 1.02959622 |
| 51 | MAP4K2 | 1.01206493 |
| 52 | NEK1 | 1.00389396 |
| 53 | FLT3 | 0.99682136 |
| 54 | IRAK4 | 0.99320736 |
| 55 | CSNK1G3 | 0.98048927 |
| 56 | PINK1 | 0.97624619 |
| 57 | STK38L | 0.95586258 |
| 58 | WNK3 | 0.93836845 |
| 59 | PLK3 | 0.93261584 |
| 60 | CSNK1G1 | 0.91212496 |
| 61 | MAP2K7 | 0.90659341 |
| 62 | CDK8 | 0.88520561 |
| 63 | TGFBR1 | 0.86571824 |
| 64 | CSNK1G2 | 0.84968184 |
| 65 | CDK4 | 0.84157921 |
| 66 | RPS6KA5 | 0.84154673 |
| 67 | STK4 | 0.82724006 |
| 68 | MAP3K8 | 0.78829027 |
| 69 | BRD4 | 0.78068620 |
| 70 | CSNK2A1 | 0.77434577 |
| 71 | ABL2 | 0.77271172 |
| 72 | OBSCN | 0.75856789 |
| 73 | ERBB4 | 0.75605242 |
| 74 | TRIM28 | 0.75150965 |
| 75 | PIM1 | 0.70860156 |
| 76 | CHEK1 | 0.70824876 |
| 77 | STK24 | 0.68223556 |
| 78 | BLK | 0.66846749 |
| 79 | SCYL2 | 0.65542629 |
| 80 | MAP3K12 | 0.65012047 |
| 81 | TESK1 | 0.64695569 |
| 82 | MELK | 0.64615831 |
| 83 | CSNK2A2 | 0.64319161 |
| 84 | TEC | 0.63814755 |
| 85 | MST1R | 0.63317065 |
| 86 | CSNK1A1L | 0.61614041 |
| 87 | ATM | 0.60990419 |
| 88 | BRSK1 | 0.58053604 |
| 89 | TAOK2 | 0.58044869 |
| 90 | PRKCI | 0.57175624 |
| 91 | EPHB2 | 0.56251991 |
| 92 | YES1 | 0.56142073 |
| 93 | MUSK | 0.54944188 |
| 94 | INSRR | 0.54567719 |
| 95 | CCNB1 | 0.53851100 |
| 96 | MAP3K10 | 0.52934413 |
| 97 | MAP3K3 | 0.52218687 |
| 98 | ERBB3 | 0.52098622 |
| 99 | PRKCG | 0.51859166 |
| 100 | MAPKAPK5 | 0.51560912 |
| 101 | CSNK1E | 0.51430252 |
| 102 | CDK2 | 0.51180336 |
| 103 | PAK1 | 0.50127886 |
| 104 | MINK1 | 0.49356957 |
| 105 | ARAF | 0.49045735 |
| 106 | MST4 | 0.47979535 |
| 107 | ILK | 0.47734779 |
| 108 | PAK4 | 0.46986306 |
| 109 | LIMK1 | 0.45798846 |
| 110 | NUAK1 | 0.42677686 |
| 111 | IRAK1 | 0.42230104 |
| 112 | MYLK | 0.41253076 |
| 113 | PIK3CG | 0.41063916 |
| 114 | GRK1 | 0.40717169 |
| 115 | OXSR1 | 0.39940533 |
| 116 | MAP2K3 | 0.39342719 |
| 117 | AKT3 | 0.38472269 |
| 118 | CDK3 | 0.37904847 |
| 119 | BMPR1B | 0.36883782 |
| 120 | CDK1 | 0.36729603 |
| 121 | CDK6 | 0.34407505 |
| 122 | DAPK3 | 0.33630109 |
| 123 | CASK | 0.33473418 |
| 124 | LRRK2 | 0.32452036 |
| 125 | DMPK | 0.32355492 |
| 126 | CAMK1 | 0.32251139 |
| 127 | PHKG2 | 0.32052872 |
| 128 | PHKG1 | 0.32052872 |
| 129 | PLK2 | 0.31972509 |
| 130 | MARK3 | 0.31024233 |
| 131 | CSNK1A1 | 0.30558674 |
| 132 | STK10 | 0.30534821 |
| 133 | IRAK2 | 0.28753537 |
| 134 | STK3 | 0.28074512 |
| 135 | TSSK6 | 0.26562899 |
| 136 | NLK | 0.25855869 |
| 137 | ZAP70 | 0.25014920 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 5.29494938 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 3.84480123 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 3.65830701 |
| 4 | Proteasome_Homo sapiens_hsa03050 | 3.60378796 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.57920344 |
| 6 | Spliceosome_Homo sapiens_hsa03040 | 3.01858286 |
| 7 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.01770047 |
| 8 | Homologous recombination_Homo sapiens_hsa03440 | 2.76803088 |
| 9 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.60290208 |
| 10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.56987164 |
| 11 | RNA transport_Homo sapiens_hsa03013 | 2.54393700 |
| 12 | Base excision repair_Homo sapiens_hsa03410 | 2.45485057 |
| 13 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.26181954 |
| 14 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.24589790 |
| 15 | Parkinsons disease_Homo sapiens_hsa05012 | 2.19128642 |
| 16 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.08818456 |
| 17 | Cell cycle_Homo sapiens_hsa04110 | 1.92832698 |
| 18 | Huntingtons disease_Homo sapiens_hsa05016 | 1.87819006 |
| 19 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.78240674 |
| 20 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.76300997 |
| 21 | Basal transcription factors_Homo sapiens_hsa03022 | 1.75055022 |
| 22 | Protein export_Homo sapiens_hsa03060 | 1.68531726 |
| 23 | RNA degradation_Homo sapiens_hsa03018 | 1.63393201 |
| 24 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.54389712 |
| 25 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.49180239 |
| 26 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.36469109 |
| 27 | Alzheimers disease_Homo sapiens_hsa05010 | 1.32825456 |
| 28 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.32287348 |
| 29 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.29391786 |
| 30 | Purine metabolism_Homo sapiens_hsa00230 | 1.27699626 |
| 31 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.23960568 |
| 32 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.16894200 |
| 33 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.15080462 |
| 34 | Sulfur relay system_Homo sapiens_hsa04122 | 1.10943209 |
| 35 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.07135850 |
| 36 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.04185091 |
| 37 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.97216581 |
| 38 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.93786992 |
| 39 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.92485995 |
| 40 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.88297276 |
| 41 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.84751765 |
| 42 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.77620220 |
| 43 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.76044317 |
| 44 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.75790942 |
| 45 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.74600404 |
| 46 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.74379806 |
| 47 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.71425773 |
| 48 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.67843808 |
| 49 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.67266369 |
| 50 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.67189910 |
| 51 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.57462862 |
| 52 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.54830681 |
| 53 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.54798802 |
| 54 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.54562788 |
| 55 | Metabolic pathways_Homo sapiens_hsa01100 | 0.54438320 |
| 56 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.54401419 |
| 57 | Legionellosis_Homo sapiens_hsa05134 | 0.52667962 |
| 58 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.50994238 |
| 59 | Carbon metabolism_Homo sapiens_hsa01200 | 0.50715922 |
| 60 | Galactose metabolism_Homo sapiens_hsa00052 | 0.46831251 |
| 61 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.45965530 |
| 62 | HTLV-I infection_Homo sapiens_hsa05166 | 0.45726434 |
| 63 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.45646723 |
| 64 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.45597691 |
| 65 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.44714176 |
| 66 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.43111057 |
| 67 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.38438301 |
| 68 | Thyroid cancer_Homo sapiens_hsa05216 | 0.37536444 |
| 69 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.37252759 |
| 70 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.37252640 |
| 71 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.35829534 |
| 72 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.34386156 |
| 73 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.34320082 |
| 74 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.34186990 |
| 75 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.33194279 |
| 76 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.32872675 |
| 77 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.32752222 |
| 78 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.32569817 |
| 79 | Phototransduction_Homo sapiens_hsa04744 | 0.32365204 |
| 80 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.32276940 |
| 81 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.31797099 |
| 82 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.31380959 |
| 83 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.30556699 |
| 84 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.29326291 |
| 85 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.29264562 |
| 86 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.27903143 |
| 87 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.27712576 |
| 88 | Apoptosis_Homo sapiens_hsa04210 | 0.26802833 |
| 89 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.26662794 |
| 90 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.26271925 |
| 91 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.26096534 |
| 92 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.24782006 |
| 93 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.24334735 |
| 94 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.23308090 |
| 95 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.23306399 |
| 96 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.22570931 |
| 97 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.22034798 |
| 98 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.21777361 |
| 99 | Alcoholism_Homo sapiens_hsa05034 | 0.21735869 |
| 100 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.20807958 |
| 101 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.20124378 |
| 102 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.19470034 |
| 103 | Peroxisome_Homo sapiens_hsa04146 | 0.19463693 |
| 104 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.18713980 |
| 105 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.18325132 |
| 106 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.17685537 |
| 107 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.17482789 |
| 108 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.17463933 |
| 109 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.17295865 |
| 110 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.16799198 |
| 111 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.16370419 |
| 112 | Measles_Homo sapiens_hsa05162 | 0.14126847 |
| 113 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.13659201 |
| 114 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.12084429 |
| 115 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.10799241 |
| 116 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.10348152 |
| 117 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.10292768 |
| 118 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.10027216 |
| 119 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.09765093 |
| 120 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.08870663 |
| 121 | Retinol metabolism_Homo sapiens_hsa00830 | 0.08590880 |
| 122 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.08564245 |
| 123 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.08557649 |

