MAMDC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G9.12349335
2collagen fibril organization (GO:0030199)4.56572901
3extracellular fibril organization (GO:0043206)4.56431755
4endodermal cell differentiation (GO:0035987)4.33376951
5cellular response to thyroid hormone stimulus (GO:0097067)4.32198529
6phagocytosis, recognition (GO:0006910)4.27921687
7positive regulation by symbiont of host defense response (GO:0052509)4.12131841
8modulation by symbiont of host defense response (GO:0052031)4.12131841
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.12131841
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.12131841
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.12131841
12modulation by symbiont of host immune response (GO:0052553)4.12131841
13neutrophil activation involved in immune response (GO:0002283)4.09404812
14negative regulation of chondrocyte differentiation (GO:0032331)4.02882540
15actin-myosin filament sliding (GO:0033275)4.01377679
16muscle filament sliding (GO:0030049)4.01377679
17retina vasculature morphogenesis in camera-type eye (GO:0061299)3.95749136
18extracellular matrix assembly (GO:0085029)3.94065666
19myoblast fusion (GO:0007520)3.93980646
20actin-mediated cell contraction (GO:0070252)3.89868778
21response to interferon-alpha (GO:0035455)3.89431563
22regulation of mononuclear cell migration (GO:0071675)3.81842980
23fibril organization (GO:0097435)3.79797328
24regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.72832892
25metanephric mesenchyme development (GO:0072075)3.70087133
26cellular response to vitamin (GO:0071295)3.66715766
27regulation of macrophage cytokine production (GO:0010935)3.64832878
28kidney mesenchyme development (GO:0072074)3.59761072
29hemidesmosome assembly (GO:0031581)3.49725710
30positive regulation of macrophage cytokine production (GO:0060907)3.48217549
31positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.47742869
32macrophage activation involved in immune response (GO:0002281)3.40896735
33endothelial cell morphogenesis (GO:0001886)3.39958207
34sequestering of extracellular ligand from receptor (GO:0035581)3.38318741
35syncytium formation by plasma membrane fusion (GO:0000768)3.36365841
36cell-substrate junction assembly (GO:0007044)3.33277557
37mesenchymal-epithelial cell signaling (GO:0060638)3.30811790
38regulation of integrin-mediated signaling pathway (GO:2001044)3.29879687
39muscle cell migration (GO:0014812)3.29695319
40negative regulation of protein localization to cell surface (GO:2000009)3.29655049
41paraxial mesoderm development (GO:0048339)3.29550335
42protein heterotrimerization (GO:0070208)3.28795528
43chondrocyte proliferation (GO:0035988)3.28499391
44blood vessel maturation (GO:0001955)3.27209895
45respiratory burst (GO:0045730)3.27178340
46bone trabecula formation (GO:0060346)3.25109477
47positive regulation of chemokine biosynthetic process (GO:0045080)3.23985669
48plasma membrane repair (GO:0001778)3.23960892
49positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.23610543
50cellular response to zinc ion (GO:0071294)3.23470517
51substrate-dependent cell migration (GO:0006929)3.23007266
52antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.21931340
53antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.21931340
54immunoglobulin mediated immune response (GO:0016064)3.21021961
55cellular response to vitamin D (GO:0071305)3.19980673
56membrane raft organization (GO:0031579)3.19520542
57response to thyroid hormone (GO:0097066)3.17716453
58positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.17487822
59actin filament-based movement (GO:0030048)3.17003919
60wound healing, spreading of epidermal cells (GO:0035313)3.15210699
61regulation of interferon-beta biosynthetic process (GO:0045357)3.14150796
62apoptotic cell clearance (GO:0043277)3.13297449
63response to host immune response (GO:0052572)3.12789599
64response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.12789599
65barbed-end actin filament capping (GO:0051016)3.11962586
66negative regulation of nitric oxide biosynthetic process (GO:0045019)3.11478025
67protein localization to cell surface (GO:0034394)3.09867029
68cell migration involved in heart development (GO:0060973)3.09446332
69positive regulation of natural killer cell differentiation (GO:0032825)3.08900327
70collagen metabolic process (GO:0032963)3.07571037
71negative regulation of cartilage development (GO:0061037)3.05181229
72hippo signaling (GO:0035329)3.04535294
73keratan sulfate catabolic process (GO:0042340)3.03903345
74regulation of glomerular filtration (GO:0003093)3.01598358
75regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.01046696
76negative regulation of cardiac muscle tissue growth (GO:0055022)3.00055707
77negative regulation of heart growth (GO:0061117)3.00055707
78production of molecular mediator involved in inflammatory response (GO:0002532)2.99255623
79defense response to protozoan (GO:0042832)2.98200775
80positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.96007988
81positive regulation of interferon-alpha production (GO:0032727)2.94475833
82negative regulation of bone mineralization (GO:0030502)2.92971059
83cardiac myofibril assembly (GO:0055003)2.92538634
84endosome to melanosome transport (GO:0035646)2.92190846
85endosome to pigment granule transport (GO:0043485)2.92190846
86skin morphogenesis (GO:0043589)2.92043788
87regulation of cholesterol storage (GO:0010885)2.89574909
88stress fiber assembly (GO:0043149)2.88021452
89smooth muscle tissue development (GO:0048745)2.87817879
90renal filtration (GO:0097205)2.87711525
91response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.87586772
92response to host (GO:0075136)2.87586772
93response to host defenses (GO:0052200)2.87586772
94myeloid cell activation involved in immune response (GO:0002275)2.87333250
95glomerular visceral epithelial cell development (GO:0072015)2.87207200
96glomerular basement membrane development (GO:0032836)2.86225305
97basement membrane organization (GO:0071711)2.85518537
98artery development (GO:0060840)2.85269350
99multicellular organismal macromolecule metabolic process (GO:0044259)2.85232701
100substrate adhesion-dependent cell spreading (GO:0034446)2.84068489
101collagen catabolic process (GO:0030574)2.83607178
102myeloid dendritic cell differentiation (GO:0043011)2.83482133
103platelet dense granule organization (GO:0060155)2.83217503
104negative regulation of cardiac muscle tissue development (GO:0055026)2.82286642
105negative regulation of biomineral tissue development (GO:0070168)2.81074724
106granulocyte activation (GO:0036230)2.80106648
107lymphangiogenesis (GO:0001946)2.79515401
108intracellular pH reduction (GO:0051452)2.79216346
109phagocytosis, engulfment (GO:0006911)2.78966035
110vascular endothelial growth factor signaling pathway (GO:0038084)2.78929381
111syncytium formation (GO:0006949)2.78313058
112endothelium development (GO:0003158)2.77666152
113extracellular matrix disassembly (GO:0022617)2.77317107
114antigen processing and presentation of endogenous antigen (GO:0019883)2.77092655
115neuron projection extension involved in neuron projection guidance (GO:1902284)2.76657463
116axon extension involved in axon guidance (GO:0048846)2.76657463
117sprouting angiogenesis (GO:0002040)2.76545582
118regulation of chemokine biosynthetic process (GO:0045073)2.76079750
119negative regulation of erythrocyte differentiation (GO:0045647)2.75433516
120detection of molecule of bacterial origin (GO:0032490)2.75059468
121pathway-restricted SMAD protein phosphorylation (GO:0060389)2.74084142
122lipopolysaccharide-mediated signaling pathway (GO:0031663)2.73713145
123wound healing, spreading of cells (GO:0044319)2.73471675
124planar cell polarity pathway involved in neural tube closure (GO:0090179)2.72968631
125regulation of cardioblast differentiation (GO:0051890)2.72609446
126extracellular matrix organization (GO:0030198)2.72171698
127positive regulation of mast cell activation (GO:0033005)2.71560875
128extracellular structure organization (GO:0043062)2.71161480
129chondrocyte development (GO:0002063)2.70834899
130regulation of interferon-alpha production (GO:0032647)2.70569584
131response to peptidoglycan (GO:0032494)2.69951804
132multicellular organismal metabolic process (GO:0044236)2.69829146
133cell migration involved in sprouting angiogenesis (GO:0002042)2.68701173
134muscle cell cellular homeostasis (GO:0046716)2.68256195
135regulation of heterotypic cell-cell adhesion (GO:0034114)2.66188213
136notochord development (GO:0030903)2.65863393
137B cell mediated immunity (GO:0019724)2.65718077
138positive regulation of hemostasis (GO:1900048)2.63821294
139positive regulation of blood coagulation (GO:0030194)2.63821294
140atrioventricular valve morphogenesis (GO:0003181)2.63753562
141cell adhesion mediated by integrin (GO:0033627)2.63523961
142response to protozoan (GO:0001562)2.61476665
143definitive hemopoiesis (GO:0060216)2.61388958
144production of molecular mediator of immune response (GO:0002440)2.61187287
145regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.60986616
146negative regulation of nitric-oxide synthase activity (GO:0051001)2.59799187
147positive regulation of p38MAPK cascade (GO:1900745)2.58592627
148positive regulation of mast cell degranulation (GO:0043306)2.58415704
149positive regulation of mast cell activation involved in immune response (GO:0033008)2.58415704
150epithelial cell-cell adhesion (GO:0090136)2.58215997
151fibroblast migration (GO:0010761)2.58161503
152adherens junction assembly (GO:0034333)2.58130458
153multicellular organismal catabolic process (GO:0044243)2.58121277
154regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.57951064
155regulation of chondrocyte differentiation (GO:0032330)2.57628134
156dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.57438407
157cellular response to interferon-alpha (GO:0035457)2.56867536
158macrophage activation (GO:0042116)2.56313480
159actomyosin structure organization (GO:0031032)2.55824318
160glomerular filtration (GO:0003094)2.55667085
161regulation of endothelial cell differentiation (GO:0045601)2.55634855
162regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.55008373
163negative regulation of lipid storage (GO:0010888)2.54641531
164maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.54464284
165actin filament depolymerization (GO:0030042)2.53845808
166positive regulation of coagulation (GO:0050820)2.53610973
167cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.53317716
168regulation of mast cell degranulation (GO:0043304)2.53082125
169antigen processing and presentation via MHC class Ib (GO:0002475)2.52978167
170regulation of cardiac muscle cell differentiation (GO:2000725)2.52717070
171myeloid dendritic cell activation (GO:0001773)2.51743176
172negative regulation of viral genome replication (GO:0045071)2.51661192
173cell-substrate adherens junction assembly (GO:0007045)2.51654349
174focal adhesion assembly (GO:0048041)2.51654349
175cytokine production involved in immune response (GO:0002367)2.51293620
176surfactant homeostasis (GO:0043129)2.50935731
177eosinophil chemotaxis (GO:0048245)2.50493187
178dendritic cell differentiation (GO:0097028)2.50332901
179positive regulation of endothelial cell differentiation (GO:0045603)2.50003708
180regulation of natural killer cell differentiation (GO:0032823)2.49744995
181low-density lipoprotein particle clearance (GO:0034383)2.43565455
182peptidyl-glutamic acid carboxylation (GO:0017187)2.43517789
183protein carboxylation (GO:0018214)2.43517789
184positive regulation of gamma-delta T cell activation (GO:0046645)2.43050039
185neutrophil activation (GO:0042119)2.42638864
186regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.41997730
187adhesion of symbiont to host cell (GO:0044650)2.38852425
188virion attachment to host cell (GO:0019062)2.38852425

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.49881752
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.00177694
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.44760796
4* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.48989642
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.40688087
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.18121858
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.18098720
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.14612237
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.96494754
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.90213639
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.79083664
12SCL_19346495_ChIP-Seq_HPC-7_Human2.77152362
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.64779441
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.64692200
15BRD4_25478319_ChIP-Seq_HGPS_Human2.56210469
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.49237998
17GATA2_21666600_ChIP-Seq_HMVEC_Human2.47819297
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.33430561
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.32447176
20GATA1_22025678_ChIP-Seq_K562_Human2.30988798
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.27353290
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.25773232
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.16439180
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09039981
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.07035246
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.04342337
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.01016170
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.99915340
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97414576
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.91996814
31* TP53_18474530_ChIP-ChIP_U2OS_Human1.91762038
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.87059977
33SOX9_24532713_ChIP-Seq_HFSC_Mouse1.86757068
34* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.86016265
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.84586355
36TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.83921405
37EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.81829993
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79084211
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.76327544
40CLOCK_20551151_ChIP-Seq_293T_Human1.75376309
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74060388
42* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.68852897
43TBX20_22080862_ChIP-Seq_HEART_Mouse1.67042751
44TBX20_22328084_ChIP-Seq_HEART_Mouse1.67042751
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.65425617
46VDR_24787735_ChIP-Seq_THP-1_Human1.65136487
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.64481090
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.63981335
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.61657222
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58135081
51NFIB_24661679_ChIP-Seq_LUNG_Mouse1.58070155
52RUNX_20019798_ChIP-Seq_JUKART_Human1.57996964
53MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.57698183
54* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.57572375
55* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.57572375
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.56105092
57STAT4_19710469_ChIP-ChIP_TH1__Mouse1.55022050
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.54054906
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50626854
60TP53_16413492_ChIP-PET_HCT116_Human1.50536681
61SPI1_23547873_ChIP-Seq_NB4_Human1.50353739
62SPI1_23127762_ChIP-Seq_K562_Human1.47389873
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46043950
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.44892448
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.44613103
66SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42609739
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.42570802
68PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.42472151
69VDR_24763502_ChIP-Seq_THP-1_Human1.42200333
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39672721
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39554235
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39170187
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38309513
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38203640
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37370526
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37352351
77ISL1_27105846_Chip-Seq_CPCs_Mouse1.35236772
78* CJUN_26792858_Chip-Seq_BT549_Human1.34576007
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33997172
80SOX2_20726797_ChIP-Seq_SW620_Human1.33912404
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33794984
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33280670
83* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.33259441
84SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.32561810
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.31103217
86HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30755543
87ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.30003508
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29420590
89RXR_22158963_ChIP-Seq_LIVER_Mouse1.28630784
90TBX3_20139965_ChIP-Seq_ESCs_Mouse1.26969074
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26565764
92TBX3_20139965_ChIP-Seq_MESCs_Mouse1.26016184
93* RUNX1_22412390_ChIP-Seq_EML_Mouse1.25850293
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23620142
95NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.21696210
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21664781
97PU_27001747_Chip-Seq_BMDM_Mouse1.21394818
98LXR_22158963_ChIP-Seq_LIVER_Mouse1.20589225
99* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18654881
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18135676
101SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18109209
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18076743
103RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16696657
104* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16154188
105* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15469910
106MAF_26560356_Chip-Seq_TH1_Human1.13529305
107SMC1_22415368_ChIP-Seq_MEFs_Mouse1.12468021
108GATA1_19941827_ChIP-Seq_MEL_Mouse1.11280372
109EED_16625203_ChIP-ChIP_MESCs_Mouse1.11116962
110* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11116515
111AHR_22903824_ChIP-Seq_MCF-7_Human1.10352033
112P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09872148
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09454065
114FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08399727
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.07771082
116UBF1/2_26484160_Chip-Seq_HMECs_Human1.07674357
117SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07312739
118EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07235538
119GATA2_19941826_ChIP-Seq_K562_Human1.07144315
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07141685
121WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06931263
122DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06877445
123PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05679071
124ESR1_21235772_ChIP-Seq_MCF-7_Human1.05049392
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04693297
126ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04575630
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04481589
128* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04353841
129JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04344153
130* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04255079
131NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04244971
132ESR2_21235772_ChIP-Seq_MCF-7_Human1.03779629
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03512903
134SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.03119083
135RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03028511
136EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03028511
137SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02961090
138EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.02377178
139RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02283339
140SA1_22415368_ChIP-Seq_MEFs_Mouse1.01971077
141PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.01944196
142TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01661340
143KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01251355
144ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01150765
145* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01034506
146SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00979383
147* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00811626
148GATA1_19941826_ChIP-Seq_K562_Human0.99527278
149TCF4_18268006_ChIP-ChIP_LS174T_Human0.99370291
150ESR1_20079471_ChIP-ChIP_T-47D_Human0.98959083
151* TP63_23658742_ChIP-Seq_EP156T_Human0.97923976
152TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96439388
153PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95829659
154* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94775528
155PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92777638
156VDR_21846776_ChIP-Seq_THP-1_Human0.91806250
157FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.91374573
158* MYB_26560356_Chip-Seq_TH2_Human0.91271517
159VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89831820
160PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87480985
161TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87436606
162GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87131553
163CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86910097
164* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84781475
165TCF7_22412390_ChIP-Seq_EML_Mouse0.84721172
166FOXO3_23340844_ChIP-Seq_DLD1_Human0.83633791
167SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82683919
168SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82683919
169JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80820740
170EP300_21415370_ChIP-Seq_HL-1_Mouse0.78900653

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006082_CNS_inflammation3.39127192
2MP0008438_abnormal_cutaneous_collagen3.31949686
3MP0005058_abnormal_lysosome_morphology3.11477001
4MP0003950_abnormal_plasma_membrane2.86889528
5MP0003724_increased_susceptibility_to2.85592942
6MP0001835_abnormal_antigen_presentation2.81061753
7MP0003436_decreased_susceptibility_to2.79975414
8MP0003172_abnormal_lysosome_physiology2.67993022
9MP0010030_abnormal_orbit_morphology2.58444006
10MP0001958_emphysema2.57097542
11MP0009785_altered_susceptibility_to2.51268197
12MP0005167_abnormal_blood-brain_barrier2.48588766
13MP0005257_abnormal_intraocular_pressure2.48280435
14MP0002148_abnormal_hypersensitivity_rea2.40770116
15MP0002419_abnormal_innate_immunity2.37621202
16MP0005623_abnormal_meninges_morphology2.35592207
17MP0010368_abnormal_lymphatic_system2.34131209
18MP0003303_peritoneal_inflammation2.31693865
19MP0003191_abnormal_cellular_cholesterol2.30229243
20MP0000749_muscle_degeneration2.30070601
21MP0005464_abnormal_platelet_physiology2.16373900
22MP0009840_abnormal_foam_cell2.15130976
23MP0001879_abnormal_lymphatic_vessel2.09762525
24MP0004084_abnormal_cardiac_muscle2.08786047
25MP0003279_aneurysm2.08025230
26MP0003075_altered_response_to2.04412639
27MP0000343_altered_response_to2.03882969
28MP0003690_abnormal_glial_cell2.02903813
29MP0005025_abnormal_response_to2.02087316
30MP0000685_abnormal_immune_system2.01225809
31MP0003941_abnormal_skin_development1.99018425
32MP0000013_abnormal_adipose_tissue1.95554300
33MP0009384_cardiac_valve_regurgitation1.93827516
34MP0002108_abnormal_muscle_morphology1.93729880
35MP0005000_abnormal_immune_tolerance1.91512724
36MP0002998_abnormal_bone_remodeling1.82287076
37MP0001533_abnormal_skeleton_physiology1.82008560
38MP0001299_abnormal_eye_distance/1.81035413
39MP0002452_abnormal_antigen_presenting1.76281188
40MP0005275_abnormal_skin_tensile1.70469412
41MP0003566_abnormal_cell_adhesion1.67493103
42MP0006054_spinal_hemorrhage1.62655990
43MP0009764_decreased_sensitivity_to1.62403417
44MP0001790_abnormal_immune_system1.59576256
45MP0005387_immune_system_phenotype1.59576256
46MP0005166_decreased_susceptibility_to1.59211626
47MP0005508_abnormal_skeleton_morphology1.58399548
48MP0002060_abnormal_skin_morphology1.57607306
49MP0000767_abnormal_smooth_muscle1.54424095
50MP0000465_gastrointestinal_hemorrhage1.53814398
51MP0004087_abnormal_muscle_fiber1.52932602
52MP0010352_gastrointestinal_tract_polyps1.51888466
53MP0004272_abnormal_basement_membrane1.50143044
54MP0004036_abnormal_muscle_relaxation1.49752236
55MP0006138_congestive_heart_failure1.48914573
56MP0004782_abnormal_surfactant_physiolog1.48571505
57MP0005174_abnormal_tail_pigmentation1.48351369
58MP0002723_abnormal_immune_serum1.47644138
59MP0000733_abnormal_muscle_development1.40760760
60MP0000759_abnormal_skeletal_muscle1.40023042
61MP0004510_myositis1.39585228
62MP0000750_abnormal_muscle_regeneration1.38888945
63MP0000762_abnormal_tongue_morphology1.37286797
64MP0001845_abnormal_inflammatory_respons1.35467101
65MP0001819_abnormal_immune_cell1.35295356
66MP0002420_abnormal_adaptive_immunity1.34417605
67MP0005620_abnormal_muscle_contractility1.34152605
68MP0003448_altered_tumor_morphology1.33650577
69MP0010386_abnormal_urinary_bladder1.33246323
70MP0002089_abnormal_postnatal_growth/wei1.32592282
71MP0005503_abnormal_tendon_morphology1.31470499
72MP0009780_abnormal_chondrocyte_physiolo1.29103590
73MP0005164_abnormal_response_to1.28411912
74MP0001800_abnormal_humoral_immune1.28343118
75MP0000249_abnormal_blood_vessel1.28103861
76MP0001853_heart_inflammation1.27344202
77MP0003385_abnormal_body_wall1.25451914
78MP0005671_abnormal_response_to1.24459114
79MP0008469_abnormal_protein_level1.23550881
80MP0002254_reproductive_system_inflammat1.23538001
81MP0001545_abnormal_hematopoietic_system1.23289900
82MP0005397_hematopoietic_system_phenotyp1.23289900
83MP0005330_cardiomyopathy1.23001829
84MP0002896_abnormal_bone_mineralization1.21543073
85MP0004808_abnormal_hematopoietic_stem1.17720373
86MP0001542_abnormal_bone_strength1.17397530
87MP0002933_joint_inflammation1.16112635
88MP0002972_abnormal_cardiac_muscle1.15385117
89MP0002877_abnormal_melanocyte_morpholog1.13713180
90MP0005390_skeleton_phenotype1.13620940
91MP0009250_abnormal_appendicular_skeleto1.13444211
92MP0002405_respiratory_system_inflammati1.13300047
93MP0003705_abnormal_hypodermis_morpholog1.12917457
94MP0003300_gastrointestinal_ulcer1.12650290
95MP0010155_abnormal_intestine_physiology1.12551732
96MP0003828_pulmonary_edema1.11624711
97MP0004130_abnormal_muscle_cell1.09708996
98MP0002269_muscular_atrophy1.06899742
99MP0003283_abnormal_digestive_organ1.06794897
100MP0005388_respiratory_system_phenotype1.06074045
101MP0002133_abnormal_respiratory_system1.06074045
102MP0003091_abnormal_cell_migration1.06062469
103MP0000462_abnormal_digestive_system1.04760723
104MP0004233_abnormal_muscle_weight1.04611393
105MP0003656_abnormal_erythrocyte_physiolo1.02105469
106MP0003011_delayed_dark_adaptation1.01523040
107MP0004947_skin_inflammation1.00714609
108MP0001661_extended_life_span1.00702271
109MP0010630_abnormal_cardiac_muscle0.99848987
110MP0002090_abnormal_vision0.99468834
111MP0009278_abnormal_bone_marrow0.98881116
112MP0000604_amyloidosis0.98372156
113MP0005369_muscle_phenotype0.98165255
114MP0001851_eye_inflammation0.97174142
115MP0000003_abnormal_adipose_tissue0.96631150
116MP0000747_muscle_weakness0.96498183
117MP0000428_abnormal_craniofacial_morphol0.96347430
118MP0004883_abnormal_blood_vessel0.95327281
119MP0000534_abnormal_ureter_morphology0.94105040
120MP0000716_abnormal_immune_system0.90820311
121MP0001915_intracranial_hemorrhage0.90741082
122MP0005023_abnormal_wound_healing0.90642617
123MP0001243_abnormal_dermal_layer0.90557466
124MP0008875_abnormal_xenobiotic_pharmacok0.90313416
125MP0002697_abnormal_eye_size0.89612202
126MP0000751_myopathy0.89053301
127MP0003795_abnormal_bone_structure0.87772604
128MP0000681_abnormal_thyroid_gland0.86288042
129MP0003942_abnormal_urinary_system0.85916925
130MP0004484_altered_response_of0.85032771
131MP0002106_abnormal_muscle_physiology0.84345789
132MP0004215_abnormal_myocardial_fiber0.81475270
133MP0003755_abnormal_palate_morphology0.81137613
134MP0000163_abnormal_cartilage_morphology0.80374624
135MP0010329_abnormal_lipoprotein_level0.79738581
136MP0002925_abnormal_cardiovascular_devel0.79660894
137MP0002932_abnormal_joint_morphology0.79659852
138MP0005670_abnormal_white_adipose0.79588319
139MP0005197_abnormal_uvea_morphology0.79168820
140MP0005595_abnormal_vascular_smooth0.79116389
141MP0005193_abnormal_anterior_eye0.78627071
142MP0000689_abnormal_spleen_morphology0.78552969
143MP0005385_cardiovascular_system_phenoty0.78098684
144MP0001544_abnormal_cardiovascular_syste0.78098684
145MP0001849_ear_inflammation0.76210179
146MP0000858_altered_metastatic_potential0.75741333
147MP0009763_increased_sensitivity_to0.75366014
148MP0005165_increased_susceptibility_to0.74489900
149MP0008775_abnormal_heart_ventricle0.74059284
150MP0002429_abnormal_blood_cell0.73409391
151MP0000432_abnormal_head_morphology0.73172116
152MP0003136_yellow_coat_color0.72816439
153MP0002295_abnormal_pulmonary_circulatio0.72473086
154MP0002136_abnormal_kidney_physiology0.71969280
155MP0009333_abnormal_splenocyte_physiolog0.71807445
156MP0002168_other_aberrant_phenotype0.71544127
157MP0003115_abnormal_respiratory_system0.71457319
158MP0001614_abnormal_blood_vessel0.70657255
159MP0001175_abnormal_lung_morphology0.70594679
160MP0005171_absent_coat_pigmentation0.70229198
161MP0002128_abnormal_blood_circulation0.69625202
162MP0002398_abnormal_bone_marrow0.69541854
163MP0000266_abnormal_heart_morphology0.69255214
164MP0004134_abnormal_chest_morphology0.68923993
165MP0002092_abnormal_eye_morphology0.67989894
166MP0002114_abnormal_axial_skeleton0.66875330
167MP0002115_abnormal_skeleton_extremities0.66488725
168MP0000049_abnormal_middle_ear0.64600768
169MP0002233_abnormal_nose_morphology0.64359327

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)5.29365033
2Recurrent gram-negative bacterial infections (HP:0005420)4.72660232
3Eczematoid dermatitis (HP:0000976)4.46064372
4Increased neuronal autofluorescent lipopigment (HP:0002074)4.38613974
5Vacuolated lymphocytes (HP:0001922)4.37798012
6Recurrent abscess formation (HP:0002722)4.34382257
7Popliteal pterygium (HP:0009756)4.19151517
8Hematochezia (HP:0002573)4.11554399
9Autoimmune thrombocytopenia (HP:0001973)3.96804040
10Vascular tortuosity (HP:0004948)3.96670364
11Abnormality of macrophages (HP:0004311)3.87067089
12Recurrent bacterial skin infections (HP:0005406)3.79389541
13Round ear (HP:0100830)3.69640943
14Arterial tortuosity (HP:0005116)3.68890679
15Abnormality of liposaccharide metabolism (HP:0010968)3.68265669
16Abnormality of glycosphingolipid metabolism (HP:0004343)3.68265669
17Abnormality of glycolipid metabolism (HP:0010969)3.68265669
18Spontaneous hematomas (HP:0007420)3.59625224
19Atrophic scars (HP:0001075)3.55719609
20Abnormality of the vasculature of the conjunctiva (HP:0008054)3.54126510
21Dysostosis multiplex (HP:0000943)3.52165329
22Ankle contracture (HP:0006466)3.40874425
23Axonal loss (HP:0003447)3.36154821
24Nemaline bodies (HP:0003798)3.26215433
25Soft skin (HP:0000977)3.24577165
26Thin ribs (HP:0000883)3.21944534
27Interstitial pulmonary disease (HP:0006530)3.18769127
28Polycythemia (HP:0001901)3.17562559
29Urinary glycosaminoglycan excretion (HP:0003541)3.17319540
30Mucopolysacchariduria (HP:0008155)3.17319540
31Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.17189103
32Protrusio acetabuli (HP:0003179)3.12567220
33Abnormality of polysaccharide metabolism (HP:0011012)3.06241556
34Abnormality of glycosaminoglycan metabolism (HP:0004371)3.06241556
35Abnormality of mucopolysaccharide metabolism (HP:0011020)3.06241556
36Bladder diverticulum (HP:0000015)3.04793775
37Spondylolisthesis (HP:0003302)3.03639984
38Wormian bones (HP:0002645)2.96948570
39Conjunctival telangiectasia (HP:0000524)2.93608385
40Abnormality of the nasal mucosa (HP:0000433)2.92608684
41Cervical subluxation (HP:0003308)2.91842894
42Loss of speech (HP:0002371)2.90370712
43Muscle fiber inclusion bodies (HP:0100299)2.89263364
44Spinal rigidity (HP:0003306)2.86488476
45Mitral valve prolapse (HP:0001634)2.85784593
46Amniotic constriction ring (HP:0009775)2.84130620
47Abnormality of placental membranes (HP:0011409)2.84130620
48Spinal cord lesions (HP:0100561)2.83908059
49Syringomyelia (HP:0003396)2.83908059
50Distal arthrogryposis (HP:0005684)2.82648143
51Vertebral compression fractures (HP:0002953)2.82466413
52Ulnar deviation of the wrist (HP:0003049)2.81142966
53J-shaped sella turcica (HP:0002680)2.80100363
54Pterygium (HP:0001059)2.79166527
55Prolonged bleeding time (HP:0003010)2.78138252
56Osteolytic defects of the hand bones (HP:0009699)2.77579374
57Osteolytic defects of the phalanges of the hand (HP:0009771)2.77579374
58Joint hemorrhage (HP:0005261)2.75839277
59Hyporeflexia of lower limbs (HP:0002600)2.75162107
60Purpura (HP:0000979)2.74645033
61Dilatation of the ascending aorta (HP:0005111)2.71478578
62Myocardial infarction (HP:0001658)2.68549887
63Calcaneovalgus deformity (HP:0001848)2.68049779
64Shallow orbits (HP:0000586)2.64021721
65Follicular hyperkeratosis (HP:0007502)2.60296255
66Type 2 muscle fiber atrophy (HP:0003554)2.59221818
67Deformed tarsal bones (HP:0008119)2.56095267
68Mediastinal lymphadenopathy (HP:0100721)2.55966162
69Neonatal short-limb short stature (HP:0008921)2.54932654
70Gowers sign (HP:0003391)2.53789719
71Epistaxis (HP:0000421)2.53384059
72Distal lower limb muscle weakness (HP:0009053)2.52628790
73Abnormality of dentin (HP:0010299)2.52112183
74Abnormality of the calf musculature (HP:0001430)2.50817006
75Cellulitis (HP:0100658)2.50712032
76Gingival bleeding (HP:0000225)2.48790544
77Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.48721272
78Increased variability in muscle fiber diameter (HP:0003557)2.47556750
79Increased connective tissue (HP:0009025)2.45926009
80Myositis (HP:0100614)2.45923791
81Limited hip movement (HP:0008800)2.45371753
82Fragile skin (HP:0001030)2.44102878
83Beaking of vertebral bodies (HP:0004568)2.42452048
84Tetraparesis (HP:0002273)2.41974506
85Aortic dissection (HP:0002647)2.39728811
86Systemic lupus erythematosus (HP:0002725)2.37514460
87Aortic regurgitation (HP:0001659)2.36502339
88Abnormality of the neuromuscular junction (HP:0003398)2.35493155
89Fatigable weakness (HP:0003473)2.35493155
90Gingivitis (HP:0000230)2.33953071
91Abnormality of the calcaneus (HP:0008364)2.33745691
92Hip contracture (HP:0003273)2.33222789
93Esophageal varix (HP:0002040)2.33073148
94Neck muscle weakness (HP:0000467)2.29988031
95Menorrhagia (HP:0000132)2.29846265
96Broad metatarsal (HP:0001783)2.29270601
97Disinhibition (HP:0000734)2.28316601
98Muscle fiber atrophy (HP:0100295)2.28231490
99Aplasia of the musculature (HP:0100854)2.27827955
100Wrist flexion contracture (HP:0001239)2.26845497
101Hypoplasia of the iris (HP:0007676)2.26655399
102Abnormality of the lumbar spine (HP:0100712)2.26544588
103Malignant hyperthermia (HP:0002047)2.26432014
104Orchitis (HP:0100796)2.25381914
105Genu recurvatum (HP:0002816)2.24918132
106Abnormality of skeletal muscle fiber size (HP:0012084)2.24895172
107Recurrent skin infections (HP:0001581)2.23902552
108Limb-girdle muscle atrophy (HP:0003797)2.23649550
109Ectopia lentis (HP:0001083)2.22880139
110Overgrowth (HP:0001548)2.22272378
111Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.21780674
112Blue sclerae (HP:0000592)2.21040148
113Premature rupture of membranes (HP:0001788)2.19799703
114Mitral stenosis (HP:0001718)2.19332740
115Arterial thrombosis (HP:0004420)2.18877843
116Mildly elevated creatine phosphokinase (HP:0008180)2.18201380
117Thoracic kyphosis (HP:0002942)2.16745249
118Aortic aneurysm (HP:0004942)2.15272287
119Muscle fiber splitting (HP:0003555)2.13456080
120Ulnar bowing (HP:0003031)2.11854558
121Biconcave vertebral bodies (HP:0004586)2.10632159
122Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.10588342
123Wide anterior fontanel (HP:0000260)2.08601218
124Osteomyelitis (HP:0002754)2.08138906
125Asymmetric septal hypertrophy (HP:0001670)2.07770880
126Weak cry (HP:0001612)2.07266015
127Alopecia of scalp (HP:0002293)2.07234309
128Increased CSF protein (HP:0002922)2.06604380
129Joint stiffness (HP:0001387)2.05349367
130Albinism (HP:0001022)2.04031893
131Aneurysm (HP:0002617)2.03573597
132Calf muscle hypertrophy (HP:0008981)2.03327987
133Elevated erythrocyte sedimentation rate (HP:0003565)2.03047654
134Pulmonary hypertension (HP:0002092)2.00313154
135Hepatosplenomegaly (HP:0001433)1.99954200
136Bowel diverticulosis (HP:0005222)1.99776226
137Camptodactyly of toe (HP:0001836)1.99463151
138Glomerulonephritis (HP:0000099)1.99366751
139Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.98984552
140Mitral regurgitation (HP:0001653)1.98461147
141Pulmonary embolism (HP:0002204)1.97631049
142Elbow flexion contracture (HP:0002987)1.97449230
143Broad face (HP:0000283)1.96609748
144Scapular winging (HP:0003691)1.96412542
145Deformed sella turcica (HP:0002681)1.96339816
146Limb-girdle muscle weakness (HP:0003325)1.95298253
147Breech presentation (HP:0001623)1.94040164
148Microcytic anemia (HP:0001935)1.93694350
149Obstructive lung disease (HP:0006536)1.92840476
150Chronic obstructive pulmonary disease (HP:0006510)1.92840476
151Amyloidosis (HP:0011034)1.92774105
152Lipoatrophy (HP:0100578)1.92468479
153Joint laxity (HP:0001388)1.91743291
154Absent frontal sinuses (HP:0002688)1.91267438
155Pulmonary artery stenosis (HP:0004415)1.91189810
156Petechiae (HP:0000967)1.88951780
157Hyperextensible skin (HP:0000974)1.88812882
158Knee flexion contracture (HP:0006380)1.88757618
159Thrombophlebitis (HP:0004418)1.86837756
160Abnormal delivery (HP:0001787)1.86472159
161Peritonitis (HP:0002586)1.86055374
162Esophageal neoplasm (HP:0100751)1.85415276
163Neoplasm of head and neck (HP:0012288)1.85415276
164Short nail (HP:0001799)1.85395272
165Aortic valve stenosis (HP:0001650)1.85074229
166Emphysema (HP:0002097)1.84914338
167Bone pain (HP:0002653)1.84394503
168Cerebral aneurysm (HP:0004944)1.83915282
169Fetal akinesia sequence (HP:0001989)1.83560971
170Nephritis (HP:0000123)1.83399809
171Urticaria (HP:0001025)1.82907013
172Abnormality of the ischium (HP:0003174)1.82329726
173Bradycardia (HP:0001662)1.80664827
174Sudden death (HP:0001699)1.78975214
175Premature loss of primary teeth (HP:0006323)1.77070625
176Type 1 muscle fiber predominance (HP:0003803)1.75806949
177Agnosia (HP:0010524)1.75460615

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.40329566
2KIT3.04710494
3ERN12.86392062
4TIE12.86232438
5LIMK12.70335771
6TGFBR12.38255705
7PIK3CG2.24514414
8LATS22.17555905
9LATS12.02744021
10JAK32.01065069
11MATK1.98286024
12EPHB21.97845853
13DMPK1.97498315
14MUSK1.96774669
15TESK11.94247344
16TYK21.89539312
17PTK21.87224118
18STK38L1.84065318
19SIK11.82776585
20TBK11.80395123
21RIPK11.77025872
22PIM21.72250254
23TTN1.72140421
24RIPK41.70593915
25MAP4K11.65101459
26TNIK1.65057395
27MAP3K141.64329894
28ZAP701.62428133
29PKN21.56993820
30MOS1.47828783
31MYLK1.45473647
32MAP3K131.45017130
33IKBKB1.39859332
34OBSCN1.38710013
35JAK11.37569745
36NTRK11.37232056
37BMX1.36851885
38MST1R1.35034128
39TRIB31.32789588
40BTK1.28888769
41STK31.28839842
42LRRK21.28727944
43GSK3A1.28341609
44MAP2K31.23116105
45FGR1.19297552
46PAK41.18401450
47ABL21.17441997
48PDK21.16233475
49STK101.14293770
50ROCK11.13756159
51EPHB11.12638839
52ROCK21.08587993
53NLK1.08558180
54CSF1R1.08368994
55MAPK71.07447225
56PDGFRA1.05763467
57DAPK31.05221658
58GRK71.05183869
59CSK1.04286502
60MAP3K61.03646029
61IKBKE1.01817765
62FLT31.01744666
63BLK1.01129363
64TEC0.99326107
65JAK20.96966404
66CAMKK20.96642924
67EPHA30.95359230
68DDR20.94769305
69RPS6KA20.94381979
70MTOR0.92835964
71NEK90.90589029
72PIK3CA0.89303416
73IRAK30.89109892
74IRAK40.89025627
75BCKDK0.88421667
76MAPK150.87823035
77FER0.85385403
78MKNK20.85231596
79CHUK0.85015776
80CDK60.83245891
81RPS6KA40.83095313
82HCK0.83058249
83TRPM70.82888885
84AKT30.82149707
85LMTK20.81108193
86SIK30.78965549
87MKNK10.76839019
88PTK60.75950463
89TAOK30.75837972
90LYN0.74272522
91STK240.73853100
92ARAF0.70538699
93CAMK1D0.70260850
94SYK0.70114439
95MET0.69429900
96SCYL20.68784420
97ERBB40.67620309
98SIK20.67374642
99GRK10.64982569
100ABL10.64464480
101CDC42BPA0.64011625
102FGFR20.63258463
103FES0.62446207
104NME20.61924569
105PAK20.61647236
106PDGFRB0.61449955
107MAP3K10.60185048
108EPHA20.59452825
109PRKD20.58885575
110MAP3K120.58527774
111FGFR40.58362609
112MAPKAPK30.58045397
113LCK0.57606197
114MAP3K110.56975702
115PRKG20.56377986
116TXK0.56058190
117PAK10.55026589
118PIM10.54729538
119MAP3K100.53486464
120CAMK2G0.51262071
121PLK20.50750892
122CAMK2D0.50310367
123IRAK10.49062511
124MAPK110.47441129
125ILK0.47254255
126PBK0.47089116
127STK380.47071528
128MAPK120.46545033
129PRKCD0.46277895
130EEF2K0.46031490
131EGFR0.45679212
132BRD40.45127789
133PRKCE0.44729001
134MAP3K70.44471631
135MAPKAPK50.43319942
136ICK0.43295401
137MARK30.43184113
138PRKD10.43114522
139MAPK40.41583217
140IGF1R0.41482658
141ERBB30.40728318
142FGFR10.39508160
143PRKCH0.39154668
144KDR0.39137025
145PTK2B0.37210689
146MAP3K50.37160477
147MELK0.36063862
148INSR0.32823368
149CSNK1G10.32668252
150DYRK1B0.31868960
151MARK20.30719561
152MAPKAPK20.29488747
153MAP2K10.28705813
154PRKAA20.28213663
155CLK10.27100776
156CDK80.26869188
157SRC0.25151157
158ADRBK10.25019270

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.58983919
2Lysosome_Homo sapiens_hsa041423.09429826
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.89457845
4Other glycan degradation_Homo sapiens_hsa005112.73593601
5Malaria_Homo sapiens_hsa051442.69894436
6Leishmaniasis_Homo sapiens_hsa051402.49558615
7Staphylococcus aureus infection_Homo sapiens_hsa051502.35004989
8Rheumatoid arthritis_Homo sapiens_hsa053232.32466648
9Adherens junction_Homo sapiens_hsa045202.25325360
10Protein digestion and absorption_Homo sapiens_hsa049742.07283940
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.02621332
12Osteoclast differentiation_Homo sapiens_hsa043801.98829062
13Complement and coagulation cascades_Homo sapiens_hsa046101.93098933
14Phagosome_Homo sapiens_hsa041451.91894601
15Hippo signaling pathway_Homo sapiens_hsa043901.80883380
16Tuberculosis_Homo sapiens_hsa051521.77349176
17Hedgehog signaling pathway_Homo sapiens_hsa043401.66379273
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.62922207
19Pertussis_Homo sapiens_hsa051331.62684471
20Vascular smooth muscle contraction_Homo sapiens_hsa042701.60151002
21Tight junction_Homo sapiens_hsa045301.58711246
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.54342440
23Basal cell carcinoma_Homo sapiens_hsa052171.53494271
24ECM-receptor interaction_Homo sapiens_hsa045121.46795563
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.45383176
26Amoebiasis_Homo sapiens_hsa051461.44659905
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43856349
28Salmonella infection_Homo sapiens_hsa051321.41795370
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39977590
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.35905644
31Platelet activation_Homo sapiens_hsa046111.29998063
32Circadian rhythm_Homo sapiens_hsa047101.29810494
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29426800
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28915516
35Toxoplasmosis_Homo sapiens_hsa051451.27922605
36TNF signaling pathway_Homo sapiens_hsa046681.27854020
37Renin secretion_Homo sapiens_hsa049241.27680399
38Apoptosis_Homo sapiens_hsa042101.27386000
39MicroRNAs in cancer_Homo sapiens_hsa052061.27148552
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.26343183
41B cell receptor signaling pathway_Homo sapiens_hsa046621.26237699
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.24094180
43Legionellosis_Homo sapiens_hsa051341.21044054
44Pathways in cancer_Homo sapiens_hsa052001.19462111
45Hematopoietic cell lineage_Homo sapiens_hsa046401.19370942
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16349367
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15637560
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.13770012
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13078711
50Melanoma_Homo sapiens_hsa052181.10040780
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10013878
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09022276
53African trypanosomiasis_Homo sapiens_hsa051431.08981297
54Measles_Homo sapiens_hsa051621.08823560
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07998045
56Renin-angiotensin system_Homo sapiens_hsa046141.07926371
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07843088
58Focal adhesion_Homo sapiens_hsa045101.05608993
59Viral myocarditis_Homo sapiens_hsa054161.05587554
60Allograft rejection_Homo sapiens_hsa053301.01929719
61PPAR signaling pathway_Homo sapiens_hsa033201.01717923
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00840029
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00549482
64Gap junction_Homo sapiens_hsa045401.00414647
65Graft-versus-host disease_Homo sapiens_hsa053320.99255749
66Asthma_Homo sapiens_hsa053100.98891378
67Antigen processing and presentation_Homo sapiens_hsa046120.97094465
68p53 signaling pathway_Homo sapiens_hsa041150.96106932
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.96048079
70Acute myeloid leukemia_Homo sapiens_hsa052210.95868262
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95177360
72Wnt signaling pathway_Homo sapiens_hsa043100.94771442
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.93178277
74Shigellosis_Homo sapiens_hsa051310.92396086
75Proteoglycans in cancer_Homo sapiens_hsa052050.92026236
76Melanogenesis_Homo sapiens_hsa049160.90269446
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84562111
78Influenza A_Homo sapiens_hsa051640.83926733
79Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83275290
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81535152
81Axon guidance_Homo sapiens_hsa043600.80671292
82Prostate cancer_Homo sapiens_hsa052150.78671838
83Bladder cancer_Homo sapiens_hsa052190.78099338
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77468019
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77079246
86Pyruvate metabolism_Homo sapiens_hsa006200.76811625
87FoxO signaling pathway_Homo sapiens_hsa040680.74516223
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.74313035
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74280305
90Selenocompound metabolism_Homo sapiens_hsa004500.73920518
91Glucagon signaling pathway_Homo sapiens_hsa049220.73343932
92Hepatitis B_Homo sapiens_hsa051610.73300959
93AMPK signaling pathway_Homo sapiens_hsa041520.72380110
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70783718
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69425378
96Chronic myeloid leukemia_Homo sapiens_hsa052200.69389204
97Thyroid hormone synthesis_Homo sapiens_hsa049180.68724168
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.67794292
99Colorectal cancer_Homo sapiens_hsa052100.67284413
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66815154
101Pancreatic cancer_Homo sapiens_hsa052120.66232435
102Oxytocin signaling pathway_Homo sapiens_hsa049210.66059771
103Chemokine signaling pathway_Homo sapiens_hsa040620.64745164
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64297128
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63721678
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63307903
107N-Glycan biosynthesis_Homo sapiens_hsa005100.62663868
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62029051
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61805120
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61791459
111Hepatitis C_Homo sapiens_hsa051600.60949390
112Rap1 signaling pathway_Homo sapiens_hsa040150.60700886
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60068035
114Sphingolipid metabolism_Homo sapiens_hsa006000.59658693
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.57087809
116Glioma_Homo sapiens_hsa052140.56737599
117Collecting duct acid secretion_Homo sapiens_hsa049660.56716656
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56580626
119Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55756964
120Prion diseases_Homo sapiens_hsa050200.55143383
121Endometrial cancer_Homo sapiens_hsa052130.54824638
122Dorso-ventral axis formation_Homo sapiens_hsa043200.54484866
123Lysine degradation_Homo sapiens_hsa003100.54166925
124Insulin resistance_Homo sapiens_hsa049310.53328563
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.52687967
126Renal cell carcinoma_Homo sapiens_hsa052110.52438576
127Histidine metabolism_Homo sapiens_hsa003400.51702607
128Cardiac muscle contraction_Homo sapiens_hsa042600.50976343
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50346770
130Dilated cardiomyopathy_Homo sapiens_hsa054140.49710928
131Sulfur metabolism_Homo sapiens_hsa009200.48613141
132Herpes simplex infection_Homo sapiens_hsa051680.48513173
133Protein export_Homo sapiens_hsa030600.48098998
134Nitrogen metabolism_Homo sapiens_hsa009100.47987674
135Small cell lung cancer_Homo sapiens_hsa052220.47506025
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45622425
137Notch signaling pathway_Homo sapiens_hsa043300.45603699
138HIF-1 signaling pathway_Homo sapiens_hsa040660.43796277
139Primary bile acid biosynthesis_Homo sapiens_hsa001200.43601170
140TGF-beta signaling pathway_Homo sapiens_hsa043500.42596201
141Insulin signaling pathway_Homo sapiens_hsa049100.41560986
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.41502142
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41341562
144ABC transporters_Homo sapiens_hsa020100.39158651
145Galactose metabolism_Homo sapiens_hsa000520.38949833
146Ras signaling pathway_Homo sapiens_hsa040140.38938269
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38743041
148Starch and sucrose metabolism_Homo sapiens_hsa005000.38615826
149Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38309904
150mTOR signaling pathway_Homo sapiens_hsa041500.37987102
151Fatty acid degradation_Homo sapiens_hsa000710.37108038
152Carbon metabolism_Homo sapiens_hsa012000.36884256
153Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36001807
154Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35788596
155PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35492122
156Prolactin signaling pathway_Homo sapiens_hsa049170.35382401
157Thyroid cancer_Homo sapiens_hsa052160.35272612
158Salivary secretion_Homo sapiens_hsa049700.35228533
159Pentose phosphate pathway_Homo sapiens_hsa000300.35153338
160Biosynthesis of amino acids_Homo sapiens_hsa012300.34253840
161GnRH signaling pathway_Homo sapiens_hsa049120.33822351
162Bile secretion_Homo sapiens_hsa049760.32882056
163Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32838162
164Mineral absorption_Homo sapiens_hsa049780.32426797
165Endocytosis_Homo sapiens_hsa041440.30838877
166Long-term depression_Homo sapiens_hsa047300.30786757
167Fatty acid elongation_Homo sapiens_hsa000620.30118957
168HTLV-I infection_Homo sapiens_hsa051660.29444564
169Estrogen signaling pathway_Homo sapiens_hsa049150.26199226

Most similar genes based on co-expression Upload to Enrichr

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