MAMDC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glucose 6-phosphate metabolic process (GO:0051156)8.21207250
2peptidyl-glutamic acid carboxylation (GO:0017187)6.15689906
3protein carboxylation (GO:0018214)6.15689906
4GDP-mannose metabolic process (GO:0019673)5.35543658
5DNA unwinding involved in DNA replication (GO:0006268)4.87940728
6positive regulation of protein kinase C signaling (GO:0090037)4.85772393
7viral transcription (GO:0019083)4.72909577
8DNA replication checkpoint (GO:0000076)4.57419441
9translational termination (GO:0006415)4.51886082
10mannose metabolic process (GO:0006013)4.49501980
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.41556386
12ribosomal small subunit assembly (GO:0000028)4.28433538
13proline metabolic process (GO:0006560)4.19993571
14rRNA catabolic process (GO:0016075)4.13440758
15translational elongation (GO:0006414)4.13244788
16nephron tubule morphogenesis (GO:0072078)4.12871657
17nephron epithelium morphogenesis (GO:0072088)4.12871657
18intra-S DNA damage checkpoint (GO:0031573)4.03172918
19regulation of cholesterol homeostasis (GO:2000188)4.00388921
20maturation of SSU-rRNA (GO:0030490)3.91621479
21urea cycle (GO:0000050)3.87289406
22high-density lipoprotein particle remodeling (GO:0034375)3.85785997
23cellular response to ATP (GO:0071318)3.77529944
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.76344968
25ribosomal large subunit biogenesis (GO:0042273)3.76041316
26urea metabolic process (GO:0019627)3.75067507
27histone-serine phosphorylation (GO:0035404)3.73479370
28DNA strand elongation involved in DNA replication (GO:0006271)3.71337216
29respiratory tube development (GO:0030323)3.70873527
30ribosomal small subunit biogenesis (GO:0042274)3.68508004
31regulation of fibrinolysis (GO:0051917)3.66554055
32negative regulation of erythrocyte differentiation (GO:0045647)3.64720338
33lung epithelium development (GO:0060428)3.63510682
34diacylglycerol metabolic process (GO:0046339)3.63261563
35very-low-density lipoprotein particle assembly (GO:0034379)3.63249838
36nuclear pore complex assembly (GO:0051292)3.61874114
37regulation of cholesterol metabolic process (GO:0090181)3.61708256
38regulation of fatty acid beta-oxidation (GO:0031998)3.56629891
39translational initiation (GO:0006413)3.56472825
40positive regulation of cell cycle G2/M phase transition (GO:1902751)3.55263392
41positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.55263392
42cellular protein complex disassembly (GO:0043624)3.53769642
43G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.50018528
44positive regulation of fatty acid beta-oxidation (GO:0032000)3.49366004
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.47799905
46semaphorin-plexin signaling pathway (GO:0071526)3.47734639
47negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.46289043
48DNA strand elongation (GO:0022616)3.45998872
49protein complex disassembly (GO:0043241)3.43848785
50dosage compensation (GO:0007549)3.43223050
51negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.42664040
52nitrogen cycle metabolic process (GO:0071941)3.40983271
53purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.38324179
543-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.38324179
55regulation of cholesterol biosynthetic process (GO:0045540)3.37225231
56plasma lipoprotein particle assembly (GO:0034377)3.36542218
57plasma lipoprotein particle remodeling (GO:0034369)3.34663280
58protein-lipid complex remodeling (GO:0034368)3.34663280
59macromolecular complex remodeling (GO:0034367)3.34663280
60reverse cholesterol transport (GO:0043691)3.32934610
61protein targeting to ER (GO:0045047)3.32279575
62DNA replication initiation (GO:0006270)3.31224078
63positive regulation of synapse maturation (GO:0090129)3.31091789
64viral life cycle (GO:0019058)3.30031351
65cotranslational protein targeting to membrane (GO:0006613)3.29855042
66IMP biosynthetic process (GO:0006188)3.26008865
67ncRNA 3-end processing (GO:0043628)3.24961440
68complement activation, alternative pathway (GO:0006957)3.24250394
69regulation of skeletal muscle contraction (GO:0014819)3.23871583
70DNA replication-dependent nucleosome organization (GO:0034723)3.21459668
71DNA replication-dependent nucleosome assembly (GO:0006335)3.21459668
72negative regulation of cholesterol transport (GO:0032375)3.20126560
73negative regulation of sterol transport (GO:0032372)3.20126560
74macromolecular complex disassembly (GO:0032984)3.19847359
75telomere maintenance via semi-conservative replication (GO:0032201)3.18204490
76negative regulation of fibrinolysis (GO:0051918)3.17081301
77plasma lipoprotein particle organization (GO:0071827)3.16827196
78cell-cell junction maintenance (GO:0045217)3.15756493
79establishment of protein localization to endoplasmic reticulum (GO:0072599)3.15161743
80peptidyl-lysine dimethylation (GO:0018027)3.13421652
81endothelial cell chemotaxis (GO:0035767)3.13386292
82nuclear pore organization (GO:0006999)3.12579220
83regulation of RNA export from nucleus (GO:0046831)3.12099470
84drug catabolic process (GO:0042737)3.11745233
85positive regulation of lipoprotein lipase activity (GO:0051006)3.08055255
86positive regulation of triglyceride lipase activity (GO:0061365)3.08055255
87nucleosome disassembly (GO:0006337)3.07060590
88protein-DNA complex disassembly (GO:0032986)3.07060590
89phospholipid efflux (GO:0033700)3.06060280
90folic acid-containing compound biosynthetic process (GO:0009396)3.05564797
91atrioventricular valve morphogenesis (GO:0003181)3.04601189
92mitotic metaphase plate congression (GO:0007080)3.04567349
93translesion synthesis (GO:0019985)3.04439786
94regulation of nuclear cell cycle DNA replication (GO:0033262)3.03880761
95regulation of plasminogen activation (GO:0010755)3.03691845
96regulation of protein activation cascade (GO:2000257)3.03588281
97DNA duplex unwinding (GO:0032508)3.02534826
98planar cell polarity pathway involved in neural tube closure (GO:0090179)3.02223681
99positive regulation of histone deacetylation (GO:0031065)3.02080977
100negative regulation of digestive system process (GO:0060457)2.98972806
101DNA geometric change (GO:0032392)2.98725694
102negative regulation of mRNA processing (GO:0050686)2.98666285
103protein localization to endoplasmic reticulum (GO:0070972)2.96774447
104regulation of complement activation (GO:0030449)2.95863203
105negative regulation of RNA splicing (GO:0033119)2.95211965
106lung-associated mesenchyme development (GO:0060484)2.95170519
107negative regulation of mRNA metabolic process (GO:1903312)2.94515309
108positive regulation of lipid catabolic process (GO:0050996)2.94415683
109positive regulation of chromosome segregation (GO:0051984)2.93768300
110protein-lipid complex subunit organization (GO:0071825)2.92691181
111telomere maintenance via recombination (GO:0000722)2.92458171
112phosphate ion homeostasis (GO:0055062)2.90441737
113trivalent inorganic anion homeostasis (GO:0072506)2.90441737
114regulation of hydrogen peroxide metabolic process (GO:0010310)2.90285476
115protein-lipid complex assembly (GO:0065005)2.90102298
116positive regulation of glycogen biosynthetic process (GO:0045725)2.88555033
117positive regulation of glycogen metabolic process (GO:0070875)2.88455660
118alkaloid metabolic process (GO:0009820)2.88341714
119glutamate metabolic process (GO:0006536)2.88033494
120carbohydrate phosphorylation (GO:0046835)2.87539148
121positive regulation of chemokine secretion (GO:0090197)2.87189513
122positive regulation of mitotic sister chromatid separation (GO:1901970)2.86389510
123positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.86389510
124positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.86389510
125positive regulation of DNA-dependent DNA replication (GO:2000105)2.86343778
126iron coordination entity transport (GO:1901678)2.86259835
127regulation of synapse maturation (GO:0090128)2.85439051
128renal tubule morphogenesis (GO:0061333)2.85247641
129bone trabecula formation (GO:0060346)2.85042592
130regulation of apoptotic cell clearance (GO:2000425)2.84785982
131cell junction maintenance (GO:0034331)2.84417397
132epithelial cell fate commitment (GO:0072148)2.83477362
133adenosine receptor signaling pathway (GO:0001973)2.82923788
134regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.82859567
135L-phenylalanine catabolic process (GO:0006559)2.82080254
136erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.82080254
137glutathione biosynthetic process (GO:0006750)2.81483732
138regulation of triglyceride catabolic process (GO:0010896)2.81108802
139protein localization to kinetochore (GO:0034501)2.80545519
140peptidyl-arginine omega-N-methylation (GO:0035247)2.79981807
141sulfate transmembrane transport (GO:1902358)2.79529981
142intestinal cholesterol absorption (GO:0030299)2.78975214
143rRNA methylation (GO:0031167)2.78971535
144mitotic recombination (GO:0006312)2.78833985
145acylglycerol homeostasis (GO:0055090)2.78791672
146triglyceride homeostasis (GO:0070328)2.78791672
147synaptic vesicle docking involved in exocytosis (GO:0016081)2.78296868
148negative regulation of gene expression, epigenetic (GO:0045814)2.76400786
149outer ear morphogenesis (GO:0042473)2.76135629
150regulation of ARF GTPase activity (GO:0032312)2.75938500
151RNA stabilization (GO:0043489)2.75849311
152mRNA stabilization (GO:0048255)2.75849311
153basement membrane organization (GO:0071711)2.75438739
154sulfur amino acid catabolic process (GO:0000098)2.75103917
155regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.75019026
156pore complex assembly (GO:0046931)2.74709779
157nuclear-transcribed mRNA catabolic process (GO:0000956)2.74560291
158positive regulation of triglyceride metabolic process (GO:0090208)2.74237881
159tetrahydrofolate metabolic process (GO:0046653)2.73489475
160DNA topological change (GO:0006265)2.73272221
161positive regulation of fatty acid oxidation (GO:0046321)2.72762620
162regulation of triglyceride metabolic process (GO:0090207)2.72107721
163ncRNA catabolic process (GO:0034661)2.71299226
164RNA catabolic process (GO:0006401)2.70465131
165positive regulation of hormone metabolic process (GO:0032352)2.70267485
166spliceosomal snRNP assembly (GO:0000387)2.70064796
167regulation of fatty acid oxidation (GO:0046320)2.69925220
168arginine metabolic process (GO:0006525)2.68662586
169phosphate ion transmembrane transport (GO:0035435)2.68420138
170mitotic nuclear envelope disassembly (GO:0007077)2.67150955
171histone H2A acetylation (GO:0043968)2.67025927
172negative regulation of cell size (GO:0045792)2.66318249
173sex determination (GO:0007530)2.66203963
174cholesterol efflux (GO:0033344)2.66117164
175urinary tract smooth muscle contraction (GO:0014848)2.64539747
176regulation of synapse structural plasticity (GO:0051823)2.64479390
177cell proliferation involved in metanephros development (GO:0072203)2.63990233
178chromosome condensation (GO:0030261)2.63632035
179acute-phase response (GO:0006953)2.63376907
180positive regulation of gamma-delta T cell activation (GO:0046645)2.62539840
181regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.62264929
182DNA conformation change (GO:0071103)2.61485247
183mesenchymal cell proliferation (GO:0010463)2.61428981
184positive regulation of fatty acid biosynthetic process (GO:0045723)2.60253395
185mRNA catabolic process (GO:0006402)2.60219925
186regulation of cytokine production involved in inflammatory response (GO:1900015)2.60215204
187lipoprotein metabolic process (GO:0042157)2.59491739
188base-excision repair (GO:0006284)2.59184329
189protein localization to chromosome, centromeric region (GO:0071459)2.58682655
190heterochromatin organization (GO:0070828)2.58404038
191cellular ketone body metabolic process (GO:0046950)2.58304622
192epoxygenase P450 pathway (GO:0019373)2.58074426
1934-hydroxyproline metabolic process (GO:0019471)2.57913097
194positive thymic T cell selection (GO:0045059)2.56893047
195middle ear morphogenesis (GO:0042474)2.55011576
196chromatin assembly or disassembly (GO:0006333)2.54479423
197telomere maintenance via telomere lengthening (GO:0010833)2.54357992
198chromatin remodeling at centromere (GO:0031055)2.52172828
199maternal placenta development (GO:0001893)2.51821089
200positive regulation of gastrulation (GO:2000543)2.50387427

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.28669959
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.85984209
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.57975010
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.48475853
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.47590299
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.36108963
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.15482292
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.96502185
9MYC_22102868_ChIP-Seq_BL_Human2.90719275
10CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.87434089
11P68_20966046_ChIP-Seq_HELA_Human2.74232423
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.73020736
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.69990049
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.64466762
15ERG_21242973_ChIP-ChIP_JURKAT_Human2.56978544
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.56501072
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.53642828
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.46388900
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.44605125
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.43479343
21CIITA_25753668_ChIP-Seq_RAJI_Human2.37528617
22VDR_21846776_ChIP-Seq_THP-1_Human2.35109219
23CTCF_27219007_Chip-Seq_Bcells_Human2.27287031
24XRN2_22483619_ChIP-Seq_HELA_Human2.24158471
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18509566
26RXR_22158963_ChIP-Seq_LIVER_Mouse2.16895387
27PPARA_22158963_ChIP-Seq_LIVER_Mouse2.15850820
28MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15118782
29SMC4_20622854_ChIP-Seq_HELA_Human2.08843638
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07739933
31TET1_21451524_ChIP-Seq_MESCs_Mouse2.07735725
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.05647757
33DROSHA_22980978_ChIP-Seq_HELA_Human1.95905908
34BCOR_27268052_Chip-Seq_Bcells_Human1.95431766
35SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.94831572
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.94016686
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.90756689
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.86105439
39EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.83599406
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.82305085
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.82094185
42* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80959670
43CTCF_27219007_Chip-Seq_ERYTHROID_Human1.80391262
44* RARB_24833708_ChIP-Seq_LIVER_Mouse1.78539084
45E2F1_20622854_ChIP-Seq_HELA_Human1.78443999
46CREB1_26743006_Chip-Seq_LNCaP_Human1.76473761
47NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.75505906
48PHF8_20622854_ChIP-Seq_HELA_Human1.74566482
49SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.73953489
50MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.71739758
51KDM2B_26808549_Chip-Seq_K562_Human1.70800292
52SA1_27219007_Chip-Seq_ERYTHROID_Human1.70257879
53SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.69108145
54MAF_26560356_Chip-Seq_TH1_Human1.68196267
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.67620616
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.66888013
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.65493678
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.63774896
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.62834579
60CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60917768
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.59985799
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59249372
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57806827
64UTX_26944678_Chip-Seq_JUKART_Human1.56894074
65CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.56458025
66TTF2_22483619_ChIP-Seq_HELA_Human1.55334792
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54678225
68VDR_24763502_ChIP-Seq_THP-1_Human1.53727614
69* TP53_22127205_ChIP-Seq_IMR90_Human1.53278430
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.52106824
71RUNX1_27514584_Chip-Seq_MCF-7_Human1.48216948
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43634942
73* RARA_24833708_ChIP-Seq_LIVER_Mouse1.42058454
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41898142
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41862890
76FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.41495238
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41331038
78TCF7_22412390_ChIP-Seq_EML_Mouse1.40313488
79DCP1A_22483619_ChIP-Seq_HELA_Human1.40021346
80FOXP3_21729870_ChIP-Seq_TREG_Human1.38751702
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.38352449
82JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36684283
83CTCF_20526341_ChIP-Seq_ESCs_Human1.36464191
84* FOXP1_21924763_ChIP-Seq_HESCs_Human1.36365939
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34882318
86* MAF_26560356_Chip-Seq_TH2_Human1.33418162
87KDM2B_26808549_Chip-Seq_DND41_Human1.33351648
88KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.31909481
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31351389
90TP63_22573176_ChIP-Seq_HFKS_Human1.30765869
91SA1_27219007_Chip-Seq_Bcells_Human1.30675422
92KDM5A_27292631_Chip-Seq_BREAST_Human1.29546617
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29222549
94* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.28808632
95HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27469880
96ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27275798
97ZNF263_19887448_ChIP-Seq_K562_Human1.26689132
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26277062
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25548860
100NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25014415
101VDR_23849224_ChIP-Seq_CD4+_Human1.24595914
102EZH2_27294783_Chip-Seq_ESCs_Mouse1.24370898
103SMC3_22415368_ChIP-Seq_MEFs_Mouse1.24229621
104SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23181507
105YY1_22570637_ChIP-Seq_MALME-3M_Human1.22559985
106TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.21789701
107CTCF_21964334_ChIP-Seq_BJAB-B_Human1.21253368
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20811551
109ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20222486
110SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19919320
111ESR1_21235772_ChIP-Seq_MCF-7_Human1.18762495
112CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.16895495
113CTCF_26484167_Chip-Seq_Bcells_Mouse1.16639342
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16630213
115SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16294362
116NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.16229479
117ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16177233
118* LXR_22292898_ChIP-Seq_THP-1_Human1.16004886
119SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15857304
120ERA_21632823_ChIP-Seq_H3396_Human1.15486369
121E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14982237
122JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.13897500
123STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13848261
124MYB_26560356_Chip-Seq_TH1_Human1.13717872
125ELK3_25401928_ChIP-Seq_HUVEC_Human1.13102765
126OCT4_19829295_ChIP-Seq_ESCs_Human1.12911914
127CTCF_21964334_Chip-Seq_Bcells_Human1.12438299
128ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11283705
129FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10354464
130SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10021036
131MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09821090
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09563033
133IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09352380
134EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08491761
135E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08288280
136ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07513582
137HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07415162
138GABP_19822575_ChIP-Seq_HepG2_Human1.06669332
139GATA6_25053715_ChIP-Seq_YYC3_Human1.05896068
140SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04247760
141LXR_22158963_ChIP-Seq_LIVER_Mouse1.03687606
142FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03572680
143POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03413137
144KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02812441
145RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.01772649
146P300_27268052_Chip-Seq_Bcells_Human1.01760094
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01536858
148SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01368755
149KDM2B_26808549_Chip-Seq_JURKAT_Human1.01195746
150YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01183992
151NCOR1_26117541_ChIP-Seq_K562_Human1.00815128
152ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00014072
153CDX2_20551321_ChIP-Seq_CACO-2_Human0.98983889
154SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98943844
155AR_21909140_ChIP-Seq_LNCAP_Human0.98521113
156SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96865163
157STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96577841
158CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95659432
159EST1_17652178_ChIP-ChIP_JURKAT_Human0.95130362
160YY1_21170310_ChIP-Seq_MESCs_Mouse0.95121808
161SCL_19346495_ChIP-Seq_HPC-7_Human0.95035875
162THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94997485
163KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94010074
164PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93399633
165GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93051883
166ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.92820155
167* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92579114
168BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92014988
169KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91953925
170RACK7_27058665_Chip-Seq_MCF-7_Human0.91063531
171KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90721158
172BCL6_27268052_Chip-Seq_Bcells_Human0.88625128
173MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.88358876
174MYB_26560356_Chip-Seq_TH2_Human0.87921781
175GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87572743
176MYC_18940864_ChIP-ChIP_HL60_Human0.87320067
177CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.86508420

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue4.41161479
2MP0002139_abnormal_hepatobiliary_system4.21694179
3MP0005360_urolithiasis3.92516807
4MP0003693_abnormal_embryo_hatching3.43103368
5MP0010030_abnormal_orbit_morphology3.38739791
6MP0005365_abnormal_bile_salt3.31605371
7MP0005409_darkened_coat_color3.24658385
8MP0001986_abnormal_taste_sensitivity3.23230108
9MP0003111_abnormal_nucleus_morphology2.94306807
10MP0000003_abnormal_adipose_tissue2.89475691
11MP0001293_anophthalmia2.75360841
12MP0005423_abnormal_somatic_nervous2.74679892
13MP0004957_abnormal_blastocyst_morpholog2.59782766
14MP0002163_abnormal_gland_morphology2.56637169
15MP0003136_yellow_coat_color2.54810128
16MP0000566_synostosis2.54447305
17MP0002396_abnormal_hematopoietic_system2.47282930
18MP0010094_abnormal_chromosome_stability2.45970504
19MP0000537_abnormal_urethra_morphology2.38320007
20MP0005171_absent_coat_pigmentation2.36443695
21MP0008875_abnormal_xenobiotic_pharmacok2.33723030
22MP0003879_abnormal_hair_cell2.28792521
23MP0003077_abnormal_cell_cycle2.27473555
24MP0005332_abnormal_amino_acid2.14786128
25MP0000538_abnormal_urinary_bladder2.08984777
26MP0003195_calcinosis2.08357192
27MP0004043_abnormal_pH_regulation2.07340383
28MP0003183_abnormal_peptide_metabolism2.07161687
29MP0010329_abnormal_lipoprotein_level1.99682664
30MP0001756_abnormal_urination1.98271007
31MP0002653_abnormal_ependyma_morphology1.95923145
32MP0002102_abnormal_ear_morphology1.89949522
33MP0008932_abnormal_embryonic_tissue1.88694503
34MP0005058_abnormal_lysosome_morphology1.85729772
35MP0001188_hyperpigmentation1.85534785
36MP0003172_abnormal_lysosome_physiology1.84881464
37MP0001502_abnormal_circadian_rhythm1.84015095
38MP0005076_abnormal_cell_differentiation1.82885190
39MP0000049_abnormal_middle_ear1.78961147
40MP0005085_abnormal_gallbladder_physiolo1.72019427
41MP0009053_abnormal_anal_canal1.66981380
42MP0000678_abnormal_parathyroid_gland1.65492130
43MP0003123_paternal_imprinting1.61703327
44MP0000613_abnormal_salivary_gland1.59023259
45MP0005174_abnormal_tail_pigmentation1.56447456
46MP0004808_abnormal_hematopoietic_stem1.51974445
47MP0002876_abnormal_thyroid_physiology1.51263663
48MP0008057_abnormal_DNA_replication1.51046295
49MP0008007_abnormal_cellular_replicative1.50038864
50MP0010307_abnormal_tumor_latency1.49661337
51MP0002092_abnormal_eye_morphology1.49171884
52MP0001849_ear_inflammation1.48816180
53MP0002282_abnormal_trachea_morphology1.48691976
54MP0004019_abnormal_vitamin_homeostasis1.48552963
55MP0001765_abnormal_ion_homeostasis1.46804991
56MP0005645_abnormal_hypothalamus_physiol1.46447517
57MP0002909_abnormal_adrenal_gland1.45820791
58MP0001666_abnormal_nutrient_absorption1.45410552
59MP0000490_abnormal_crypts_of1.40060207
60MP0002249_abnormal_larynx_morphology1.39665458
61MP0001661_extended_life_span1.39524977
62MP0000350_abnormal_cell_proliferation1.37796515
63MP0000428_abnormal_craniofacial_morphol1.37054060
64MP0002638_abnormal_pupillary_reflex1.36865521
65MP0008058_abnormal_DNA_repair1.36144462
66MP0000383_abnormal_hair_follicle1.33017453
67MP0004858_abnormal_nervous_system1.31614891
68MP0003942_abnormal_urinary_system1.29941704
69MP0001348_abnormal_lacrimal_gland1.28372842
70MP0003566_abnormal_cell_adhesion1.27100018
71MP0000703_abnormal_thymus_morphology1.27012644
72MP0005375_adipose_tissue_phenotype1.26996939
73MP0009379_abnormal_foot_pigmentation1.26526160
74MP0003763_abnormal_thymus_physiology1.25898099
75MP0001873_stomach_inflammation1.25737135
76MP0001664_abnormal_digestion1.24683770
77MP0003315_abnormal_perineum_morphology1.24505055
78MP0001968_abnormal_touch/_nociception1.24285889
79MP0003115_abnormal_respiratory_system1.23631311
80MP0009780_abnormal_chondrocyte_physiolo1.21001797
81MP0001697_abnormal_embryo_size1.19881202
82MP0002697_abnormal_eye_size1.18221029
83MP0003283_abnormal_digestive_organ1.17542842
84MP0000733_abnormal_muscle_development1.16959010
85MP0004381_abnormal_hair_follicle1.16574450
86MP0009672_abnormal_birth_weight1.16085501
87MP0005448_abnormal_energy_balance1.15677318
88MP0003937_abnormal_limbs/digits/tail_de1.15544503
89MP0002118_abnormal_lipid_homeostasis1.15281446
90MP0005330_cardiomyopathy1.14466320
91MP0009643_abnormal_urine_homeostasis1.14050094
92MP0000751_myopathy1.13500005
93MP0003300_gastrointestinal_ulcer1.13154553
94MP0002166_altered_tumor_susceptibility1.12767544
95MP0009384_cardiac_valve_regurgitation1.11039488
96MP0000569_abnormal_digit_pigmentation1.10193408
97MP0002089_abnormal_postnatal_growth/wei1.09700259
98MP0002080_prenatal_lethality1.09664020
99MP0001915_intracranial_hemorrhage1.08028882
100MP0005380_embryogenesis_phenotype1.07790707
101MP0001672_abnormal_embryogenesis/_devel1.07790707
102MP0003119_abnormal_digestive_system1.07383676
103MP0002398_abnormal_bone_marrow1.06822403
104MP0004264_abnormal_extraembryonic_tissu1.05124723
105MP0004185_abnormal_adipocyte_glucose1.04999801
106MP0003385_abnormal_body_wall1.04559943
107MP0005083_abnormal_biliary_tract1.04537711
108MP0001730_embryonic_growth_arrest1.01856739
109MP0002085_abnormal_embryonic_tissue1.01016634
110MP0002132_abnormal_respiratory_system0.98676557
111MP0002932_abnormal_joint_morphology0.97626697
112MP0004197_abnormal_fetal_growth/weight/0.97370510
113MP0001944_abnormal_pancreas_morphology0.96980782
114MP0000477_abnormal_intestine_morphology0.96936634
115MP0005220_abnormal_exocrine_pancreas0.95533984
116MP0001346_abnormal_lacrimal_gland0.94903436
117MP0000313_abnormal_cell_death0.94245599
118MP0003121_genomic_imprinting0.93447419
119MP0003935_abnormal_craniofacial_develop0.92728167
120MP0003045_fibrosis0.92694610
121MP0002088_abnormal_embryonic_growth/wei0.92678955
122MP0003984_embryonic_growth_retardation0.92569471
123MP0000689_abnormal_spleen_morphology0.91150952
124MP0003011_delayed_dark_adaptation0.90006227
125MP0002111_abnormal_tail_morphology0.89467794
126MP0002138_abnormal_hepatobiliary_system0.88251963
127MP0002086_abnormal_extraembryonic_tissu0.87446288
128MP0003122_maternal_imprinting0.87087581
129MP0002078_abnormal_glucose_homeostasis0.87081340
130MP0009840_abnormal_foam_cell0.86787123
131MP0002722_abnormal_immune_system0.85374832
132MP0002234_abnormal_pharynx_morphology0.84118443
133MP0005197_abnormal_uvea_morphology0.83025846
134MP0002084_abnormal_developmental_patter0.82937768
135MP0010386_abnormal_urinary_bladder0.82806170
136MP0001286_abnormal_eye_development0.82745541
137MP0000462_abnormal_digestive_system0.81646026
138MP0000609_abnormal_liver_physiology0.81375191
139MP0002938_white_spotting0.80181371
140MP0002822_catalepsy0.79052205
141MP0008961_abnormal_basal_metabolism0.78512759
142MP0003646_muscle_fatigue0.77938720
143MP0001270_distended_abdomen0.77593709
144MP0005451_abnormal_body_composition0.77477424
145MP0005167_abnormal_blood-brain_barrier0.77121474
146MP0000015_abnormal_ear_pigmentation0.76240707
147MP0002429_abnormal_blood_cell0.75297512
148MP0002933_joint_inflammation0.75087638
149MP0002735_abnormal_chemical_nociception0.74739238
150MP0002136_abnormal_kidney_physiology0.74682908
151MP0005636_abnormal_mineral_homeostasis0.74059846
152MP0005381_digestive/alimentary_phenotyp0.73940891
153MP0001958_emphysema0.73706515
154MP0005187_abnormal_penis_morphology0.73104991
155MP0001800_abnormal_humoral_immune0.72903812
156MP0003453_abnormal_keratinocyte_physiol0.71216654
157MP0003755_abnormal_palate_morphology0.71062942
158MP0002019_abnormal_tumor_incidence0.70229381
159MP0001764_abnormal_homeostasis0.70129140
160MP0000716_abnormal_immune_system0.69498786
161MP0002160_abnormal_reproductive_system0.69445652
162MP0005377_hearing/vestibular/ear_phenot0.69358142
163MP0003878_abnormal_ear_physiology0.69358142
164MP0003705_abnormal_hypodermis_morpholog0.68367525
165MP0005391_vision/eye_phenotype0.68086661
166MP0002970_abnormal_white_adipose0.67445956
167MP0000470_abnormal_stomach_morphology0.66788794
168MP0003953_abnormal_hormone_level0.65733576
169MP0004133_heterotaxia0.62875700
170MP0003252_abnormal_bile_duct0.62295651
171MP0000639_abnormal_adrenal_gland0.59810306
172MP0009642_abnormal_blood_homeostasis0.59639827
173MP0009931_abnormal_skin_appearance0.59095706
174MP0004145_abnormal_muscle_electrophysio0.57659078
175MP0003137_abnormal_impulse_conducting0.57367224
176MP0004130_abnormal_muscle_cell0.56979686
177MP0008775_abnormal_heart_ventricle0.55632886
178MP0003329_amyloid_beta_deposits0.54754908
179MP0003279_aneurysm0.52657712
180MP0003866_abnormal_defecation0.52025885

Predicted human phenotypes

RankGene SetZ-score
1Abnormal gallbladder physiology (HP:0012438)6.77463542
2Cholecystitis (HP:0001082)6.77463542
3Prolonged partial thromboplastin time (HP:0003645)4.72588871
4Peripheral hypomyelination (HP:0007182)4.68586352
5Decreased number of large peripheral myelinated nerve fibers (HP:0003387)4.48812387
6Morphological abnormality of the middle ear (HP:0008609)4.47399596
7Thin bony cortex (HP:0002753)4.41921822
8Joint hemorrhage (HP:0005261)4.33755414
9Testicular atrophy (HP:0000029)4.30150623
10Absent eyelashes (HP:0000561)4.11047974
11Deep venous thrombosis (HP:0002625)4.06518486
12Bilateral microphthalmos (HP:0007633)4.02359971
13Chin dimple (HP:0010751)3.89865508
14Rib fusion (HP:0000902)3.85722234
15Malnutrition (HP:0004395)3.78948529
16Hemorrhage of the eye (HP:0011885)3.71392707
17Bifid tongue (HP:0010297)3.63245871
18Ulnar bowing (HP:0003031)3.58397506
19Intestinal fistula (HP:0100819)3.48440155
20Midline defect of the nose (HP:0004122)3.45308143
21Down-sloping shoulders (HP:0200021)3.45117525
22Reticulocytopenia (HP:0001896)3.41069608
23Vaginal fistula (HP:0004320)3.39401604
24Thoracolumbar scoliosis (HP:0002944)3.31055808
25Annular pancreas (HP:0001734)3.27163242
26Turricephaly (HP:0000262)3.26552786
27Facial cleft (HP:0002006)3.24429261
28Broad face (HP:0000283)3.21009512
29Abnormality of reticulocytes (HP:0004312)3.12975271
30Cholelithiasis (HP:0001081)3.11206747
31Severe visual impairment (HP:0001141)3.01665275
32Rectovaginal fistula (HP:0000143)3.00434985
33Rectal fistula (HP:0100590)3.00434985
34Overlapping toe (HP:0001845)3.00266078
35Reticulocytosis (HP:0001923)2.97172207
36Cerebral aneurysm (HP:0004944)2.93554786
37Abnormality of the fingertips (HP:0001211)2.87344038
38Rectal prolapse (HP:0002035)2.85244116
39Cutaneous finger syndactyly (HP:0010554)2.84682098
40Coronal craniosynostosis (HP:0004440)2.84197472
41Abnormal number of incisors (HP:0011064)2.81997537
42Absent eyebrow (HP:0002223)2.81155801
43Abnormality of monocarboxylic acid metabolism (HP:0010996)2.80106222
44Facial hemangioma (HP:0000329)2.79635043
45Abnormality of glutamine family amino acid metabolism (HP:0010902)2.77817650
46Xanthomatosis (HP:0000991)2.76353334
47Hyperacusis (HP:0010780)2.76023609
48J-shaped sella turcica (HP:0002680)2.74963069
49Abnormality of the lacrimal duct (HP:0011481)2.72402723
50Joint stiffness (HP:0001387)2.68330233
51Hypobetalipoproteinemia (HP:0003563)2.67660922
52Abnormal lung lobation (HP:0002101)2.66417752
53Neoplasm of the heart (HP:0100544)2.66395747
54Abnormal gallbladder morphology (HP:0012437)2.64522049
55Aplasia/Hypoplasia of the sternum (HP:0006714)2.60329541
56Bicornuate uterus (HP:0000813)2.59140105
57Cutaneous syndactyly (HP:0012725)2.58414837
58Choanal stenosis (HP:0000452)2.57062087
59Cervical subluxation (HP:0003308)2.55223918
60Renal duplication (HP:0000075)2.53057538
61Obstructive sleep apnea (HP:0002870)2.50157034
62Confusion (HP:0001289)2.49992332
63Complement deficiency (HP:0004431)2.49292059
64Abnormality of the intrinsic pathway (HP:0010989)2.48714373
65Anophthalmia (HP:0000528)2.46926751
66Popliteal pterygium (HP:0009756)2.46497845
67Skull defect (HP:0001362)2.45687737
68Myelomeningocele (HP:0002475)2.45003817
69Diastasis recti (HP:0001540)2.44551299
70Cleft eyelid (HP:0000625)2.43013114
71Vertebral arch anomaly (HP:0008438)2.41459900
72Asymmetry of the thorax (HP:0001555)2.39924060
73Akinesia (HP:0002304)2.39306047
74Abnormality of the nasolacrimal system (HP:0000614)2.39289536
75Stridor (HP:0010307)2.38666292
76Overriding aorta (HP:0002623)2.38585522
77Lymphangioma (HP:0100764)2.37273185
78Atresia of the external auditory canal (HP:0000413)2.34165109
79Flat acetabular roof (HP:0003180)2.32333353
80Aplasia/Hypoplasia of the patella (HP:0006498)2.31401806
81Recurrent bronchitis (HP:0002837)2.29092921
82Poikiloderma (HP:0001029)2.28763157
83Abnormality of the pubic bones (HP:0003172)2.28380250
84Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.28355749
85Urinary glycosaminoglycan excretion (HP:0003541)2.28036422
86Mucopolysacchariduria (HP:0008155)2.28036422
87Mesangial abnormality (HP:0001966)2.25855346
88Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.25392694
89Elfin facies (HP:0004428)2.25256969
90Bowed forearm bones (HP:0003956)2.22843373
91Bowing of the arm (HP:0006488)2.22843373
92Hyperlipoproteinemia (HP:0010980)2.22393820
93Renovascular hypertension (HP:0100817)2.21790548
94Neonatal onset (HP:0003623)2.21304388
95Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.20182161
96Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16826767
97Abnormality of polysaccharide metabolism (HP:0011012)2.16826767
98Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16826767
99Pterygium (HP:0001059)2.16520115
100Decreased circulating renin level (HP:0003351)2.16062146
101Bronchomalacia (HP:0002780)2.15863411
102Delayed epiphyseal ossification (HP:0002663)2.14116345
103Patellar aplasia (HP:0006443)2.13380609
104Hydroxyprolinuria (HP:0003080)2.12745428
105Abnormality of proline metabolism (HP:0010907)2.12745428
106Abnormality of homocysteine metabolism (HP:0010919)2.12693566
107Homocystinuria (HP:0002156)2.12693566
108Hyperinsulinemic hypoglycemia (HP:0000825)2.12099354
109Renal hypoplasia (HP:0000089)2.11830076
110Submucous cleft hard palate (HP:0000176)2.08645785
111Systemic lupus erythematosus (HP:0002725)2.08197531
112Chromosomal breakage induced by crosslinking agents (HP:0003221)2.05407259
113Panhypogammaglobulinemia (HP:0003139)2.03933732
114Abnormality of the 1st metacarpal (HP:0010009)2.03929138
115Delayed CNS myelination (HP:0002188)2.03487142
116Late onset (HP:0003584)2.02799466
117Abnormality of the renal collecting system (HP:0004742)2.02764235
118Squamous cell carcinoma (HP:0002860)2.02478798
119Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.00185044
120Short 4th metacarpal (HP:0010044)2.00185044
121Abnormality of complement system (HP:0005339)1.99739747
122Meckel diverticulum (HP:0002245)1.98647913
123Hyperbilirubinemia (HP:0002904)1.98389617
124Chromsome breakage (HP:0040012)1.98230187
125Enlarged epiphyses (HP:0010580)1.97822378
126Tracheal stenosis (HP:0002777)1.97808852
127Anteriorly placed anus (HP:0001545)1.96397935
128Split foot (HP:0001839)1.93871333
129Bicuspid aortic valve (HP:0001647)1.93456335
130Abnormality of aromatic amino acid family metabolism (HP:0004338)1.93005921
131Abdominal distention (HP:0003270)1.92858613
132Flat capital femoral epiphysis (HP:0003370)1.91648463
133Hypolipoproteinemia (HP:0010981)1.89862777
134Abnormality of the thymus (HP:0000777)1.89836552
135Broad distal phalanx of finger (HP:0009836)1.89273064
136Decreased muscle mass (HP:0003199)1.89117021
137Abnormality of the gallbladder (HP:0005264)1.88933366
138Short phalanx of the thumb (HP:0009660)1.88508926
139Short chin (HP:0000331)1.87921887
140Hypoalbuminemia (HP:0003073)1.87545912
141Abnormal albumin level (HP:0012116)1.87545912
142Myopathic facies (HP:0002058)1.86462878
143Glomerulonephritis (HP:0000099)1.86282447
144Flattened epiphyses (HP:0003071)1.86073999
145Ketosis (HP:0001946)1.85996769
146Aplasia/hypoplasia of the femur (HP:0005613)1.84960019
147Increased nuchal translucency (HP:0010880)1.84760388
148Hypoalphalipoproteinemia (HP:0003233)1.83715416
149Abnormality of the ileum (HP:0001549)1.83080483
150Acute lymphatic leukemia (HP:0006721)1.80689822
151Abnormality of the vitreous humor (HP:0004327)1.80254235
152Widely patent fontanelles and sutures (HP:0004492)1.80007715
153Megaloblastic anemia (HP:0001889)1.79782576
154Oligodactyly (HP:0012165)1.79591280
155Insomnia (HP:0100785)1.79199943
156Cellular immunodeficiency (HP:0005374)1.78877193
157Abnormality of cells of the erythroid lineage (HP:0012130)1.78828893
158Acanthocytosis (HP:0001927)1.78761441
159Visceral angiomatosis (HP:0100761)1.78741200
160Skin tags (HP:0010609)1.78383173
161Abnormality of the carotid arteries (HP:0005344)1.78351474
162Wide nose (HP:0000445)1.76586289
163Oligodactyly (hands) (HP:0001180)1.76108812
164Hypophosphatemic rickets (HP:0004912)1.75391630
165Basal cell carcinoma (HP:0002671)1.74562943
166Preauricular skin tag (HP:0000384)1.73807635
167Abnormality of small intestinal villus morphology (HP:0011472)1.73755366
168Villous atrophy (HP:0011473)1.73755366
169Congenital stationary night blindness (HP:0007642)1.73101971
170Abnormality of the femoral head (HP:0003368)1.72458605
171Dicarboxylic aciduria (HP:0003215)1.72324497
172Abnormality of dicarboxylic acid metabolism (HP:0010995)1.72324497
173Protuberant abdomen (HP:0001538)1.71898728
174Pallor (HP:0000980)1.71672326
175Aplasia of the musculature (HP:0100854)1.71501746
176Shallow orbits (HP:0000586)1.71182167
177Absent phalangeal crease (HP:0006109)1.70529238
178Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.70306747
179Short 1st metacarpal (HP:0010034)1.70306747
180Short 5th finger (HP:0009237)1.70289834
181Abnormality of pyrimidine metabolism (HP:0004353)1.70110315
182Narrow nasal bridge (HP:0000446)1.69701083
183Stomach cancer (HP:0012126)1.69441948
184Aplasia/Hypoplasia of the uvula (HP:0010293)1.69111053
185Short humerus (HP:0005792)1.69081295
186Pendular nystagmus (HP:0012043)1.68994785
187Muscle fiber atrophy (HP:0100295)1.68824345
188Urethral obstruction (HP:0000796)1.68172132
189Cheilitis (HP:0100825)1.67954097
190Macrocytic anemia (HP:0001972)1.67295785
191Hypospadias (HP:0000047)1.66271363
192Abnormality of the aortic arch (HP:0012303)1.66174291
193Thin ribs (HP:0000883)1.64921732
194Abnormality of the preputium (HP:0100587)1.64559012
195Delayed closure of the anterior fontanelle (HP:0001476)1.63456905
196Ureteral stenosis (HP:0000071)1.63002783
197Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.61868600

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK19.36091551
2MAPK153.76033509
3WNK43.69458602
4BLK3.39688952
5TESK22.98019386
6MAP4K12.67104626
7MAP2K62.52760441
8PKN22.38927755
9TRIB32.35174092
10MAP3K102.33661842
11FLT32.17395257
12NEK22.07695225
13MST1R1.89014661
14TNK21.88000932
15MAP3K71.76685144
16CDC71.68428909
17MKNK21.61085677
18PHKG11.58371322
19PHKG21.58371322
20CDK121.54501604
21PRKD21.53372335
22ZAP701.53069631
23MARK21.52712742
24TESK11.52163414
25CDK81.51622314
26EEF2K1.50185811
27WNK11.50105199
28SIK11.50069833
29PTK2B1.49914795
30SMG11.45518611
31ZAK1.44351210
32NTRK31.40973854
33RPS6KA21.38588111
34PTK61.34674988
35NME21.28612037
36CAMK1D1.27653666
37CDC42BPA1.26070441
38SIK21.21514338
39FGFR31.19980118
40DAPK21.19042234
41CDK71.17819306
42KIT1.15823482
43RPS6KL11.13708615
44RPS6KC11.13708615
45TTN1.07062086
46TYRO31.06447317
47RPS6KA61.05624071
48ERN11.05523175
49RPS6KA41.04382366
50SRPK11.02843203
51PDPK11.00203472
52ATR0.98808386
53WEE10.98241759
54PRKD30.98110264
55MUSK0.97697359
56MET0.94535401
57LMTK20.94364048
58EPHB20.94137057
59MAPK120.90615765
60MKNK10.89774204
61BTK0.87342461
62NEK90.86742385
63MAPKAPK30.86540849
64PRKAA10.85084760
65AURKB0.85022515
66CAMK1G0.83946576
67MAP3K60.83610087
68INSRR0.83200357
69PTK20.81702699
70CSF1R0.81565759
71STK160.81391480
72PRKCI0.80802707
73PASK0.79665905
74RPS6KB20.79558893
75ILK0.78249886
76MAP3K80.78140160
77VRK10.77127694
78PLK10.76379550
79CDK40.76021166
80HIPK20.75191875
81STK390.74045748
82TYK20.73279284
83MYLK0.72545077
84PAK40.72544005
85MAPK110.72436630
86DDR20.71530840
87TAOK30.68886939
88MTOR0.68784367
89CHEK20.67603682
90STK40.66127983
91RET0.65670507
92MAPK70.65631463
93RIPK10.64262612
94TEC0.63972493
95MAP2K30.62488482
96BRD40.62421214
97TBK10.59887751
98ACVR1B0.59148931
99FGFR40.57883600
100MAPK80.57670708
101FGFR20.57224444
102TGFBR10.56886752
103SGK4940.56271776
104SGK2230.56271776
105DAPK30.55829253
106CAMK40.55357949
107BUB10.55259926
108TSSK60.54959812
109CAMKK20.53875894
110NME10.53644589
111MAP2K40.53494287
112AKT20.53307210
113CDK20.51721209
114JAK30.50076544
115CAMK10.49988580
116ATM0.49370252
117EPHA20.47832648
118LIMK10.47680506
119PDGFRA0.47424308
120MAP2K20.47366630
121ICK0.46813754
122TXK0.46353185
123CHEK10.43764387
124GRK60.43343650
125TTK0.43196486
126LRRK20.42595631
127PRKCH0.42212370
128CHUK0.41656200
129FRK0.41448395
130STK110.41263851
131SYK0.41119053
132SCYL20.40033032
133IRAK30.39911892
134AKT30.39445753
135BMX0.39134433
136PRKG20.39007927
137LCK0.38925021
138MARK30.38339781
139IRAK20.38246778
140JAK20.37905844
141RPS6KA10.37844668
142TAOK10.36817115
143PDK10.36435926
144NLK0.35468735
145ITK0.35170164
146PIM10.35046224
147DYRK1B0.33697772
148STK100.31888507
149PRKD10.31333117
150CAMKK10.31330383
151ERBB20.30969226
152AKT10.30960986
153AURKA0.29265214
154MAPK10.29251967
155PRKAA20.29173896
156PIK3CA0.28575191
157PRKDC0.28434442
158PAK20.28313777
159PRKCZ0.28184155
160SGK10.27248062
161CDK10.26681965
162NTRK20.25246122

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005249.86016878
2DNA replication_Homo sapiens_hsa030303.27549090
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.20112057
4Other glycan degradation_Homo sapiens_hsa005113.19118321
5Arginine biosynthesis_Homo sapiens_hsa002202.95634794
6Ribosome_Homo sapiens_hsa030102.75053088
7One carbon pool by folate_Homo sapiens_hsa006702.72929153
8Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.69385770
9Homologous recombination_Homo sapiens_hsa034402.40028467
10Galactose metabolism_Homo sapiens_hsa000522.37383876
11Mismatch repair_Homo sapiens_hsa034302.34609442
12Complement and coagulation cascades_Homo sapiens_hsa046102.34040760
13Spliceosome_Homo sapiens_hsa030402.23958647
14Base excision repair_Homo sapiens_hsa034102.15145322
15Vitamin digestion and absorption_Homo sapiens_hsa049772.11097381
16Sulfur relay system_Homo sapiens_hsa041221.98508070
17Fructose and mannose metabolism_Homo sapiens_hsa000511.91102316
18ABC transporters_Homo sapiens_hsa020101.87317329
19Bile secretion_Homo sapiens_hsa049761.84210919
20Histidine metabolism_Homo sapiens_hsa003401.59986750
21Basal cell carcinoma_Homo sapiens_hsa052171.56788179
22Systemic lupus erythematosus_Homo sapiens_hsa053221.50917798
23Starch and sucrose metabolism_Homo sapiens_hsa005001.47744403
24Fanconi anemia pathway_Homo sapiens_hsa034601.46970506
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.45708357
26Cell cycle_Homo sapiens_hsa041101.44410965
27Lysine degradation_Homo sapiens_hsa003101.39332270
28PPAR signaling pathway_Homo sapiens_hsa033201.37778237
29Retinol metabolism_Homo sapiens_hsa008301.36917524
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.36624247
31Carbohydrate digestion and absorption_Homo sapiens_hsa049731.34445497
32RNA transport_Homo sapiens_hsa030131.34165999
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.33218731
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.32369516
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30027037
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.25010492
37Primary immunodeficiency_Homo sapiens_hsa053401.23708893
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.23288399
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17548958
40Insulin secretion_Homo sapiens_hsa049111.15490666
41Chemical carcinogenesis_Homo sapiens_hsa052041.11196098
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05894121
43Pyrimidine metabolism_Homo sapiens_hsa002401.04512622
44Mineral absorption_Homo sapiens_hsa049781.03289814
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.03195120
46Carbon metabolism_Homo sapiens_hsa012001.01566265
47Sphingolipid metabolism_Homo sapiens_hsa006001.00920990
48Nucleotide excision repair_Homo sapiens_hsa034201.00650956
49Arginine and proline metabolism_Homo sapiens_hsa003300.98737134
50Phenylalanine metabolism_Homo sapiens_hsa003600.97330367
51HTLV-I infection_Homo sapiens_hsa051660.97077642
52Butanoate metabolism_Homo sapiens_hsa006500.96226009
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96003515
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95026675
55Fatty acid metabolism_Homo sapiens_hsa012120.93544870
56Pentose phosphate pathway_Homo sapiens_hsa000300.93087106
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93081114
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92144586
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91402092
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90305464
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90288583
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90220357
63Glucagon signaling pathway_Homo sapiens_hsa049220.89613726
64Linoleic acid metabolism_Homo sapiens_hsa005910.88791627
65Cocaine addiction_Homo sapiens_hsa050300.84929658
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79192681
67Small cell lung cancer_Homo sapiens_hsa052220.78716921
68Ovarian steroidogenesis_Homo sapiens_hsa049130.78716029
69Non-homologous end-joining_Homo sapiens_hsa034500.77530085
70Acute myeloid leukemia_Homo sapiens_hsa052210.76154907
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75892047
72Protein digestion and absorption_Homo sapiens_hsa049740.75456469
73p53 signaling pathway_Homo sapiens_hsa041150.75437752
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75115288
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74452965
76RNA polymerase_Homo sapiens_hsa030200.74350755
77Tryptophan metabolism_Homo sapiens_hsa003800.74091624
78AMPK signaling pathway_Homo sapiens_hsa041520.73802393
79Bladder cancer_Homo sapiens_hsa052190.73325664
80Biosynthesis of amino acids_Homo sapiens_hsa012300.73302436
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71631660
82Thyroid cancer_Homo sapiens_hsa052160.71108654
83mTOR signaling pathway_Homo sapiens_hsa041500.71003360
84Glycerolipid metabolism_Homo sapiens_hsa005610.70049340
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.69976854
86Drug metabolism - other enzymes_Homo sapiens_hsa009830.69637341
87Herpes simplex infection_Homo sapiens_hsa051680.69108460
88mRNA surveillance pathway_Homo sapiens_hsa030150.69086272
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68719979
90Peroxisome_Homo sapiens_hsa041460.68570733
91Chronic myeloid leukemia_Homo sapiens_hsa052200.67915468
92Fatty acid biosynthesis_Homo sapiens_hsa000610.65975854
93HIF-1 signaling pathway_Homo sapiens_hsa040660.64697743
94Renin-angiotensin system_Homo sapiens_hsa046140.63570520
95VEGF signaling pathway_Homo sapiens_hsa043700.62643761
96Tyrosine metabolism_Homo sapiens_hsa003500.62570111
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.62460908
98Caffeine metabolism_Homo sapiens_hsa002320.60427510
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.60173523
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60091634
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60068153
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59741979
103Antigen processing and presentation_Homo sapiens_hsa046120.58949802
104RNA degradation_Homo sapiens_hsa030180.57794710
105Ether lipid metabolism_Homo sapiens_hsa005650.57193318
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56944277
107Viral carcinogenesis_Homo sapiens_hsa052030.56340792
108Thyroid hormone synthesis_Homo sapiens_hsa049180.54539063
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.54526923
110Taste transduction_Homo sapiens_hsa047420.53939451
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52974827
112Prion diseases_Homo sapiens_hsa050200.52827093
113Hedgehog signaling pathway_Homo sapiens_hsa043400.50752569
114Pyruvate metabolism_Homo sapiens_hsa006200.49883456
115Circadian rhythm_Homo sapiens_hsa047100.49554593
116GnRH signaling pathway_Homo sapiens_hsa049120.49508054
117Notch signaling pathway_Homo sapiens_hsa043300.49437246
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49354542
119Prostate cancer_Homo sapiens_hsa052150.48684277
120Insulin signaling pathway_Homo sapiens_hsa049100.48661275
121Selenocompound metabolism_Homo sapiens_hsa004500.46350684
122B cell receptor signaling pathway_Homo sapiens_hsa046620.45128079
123Type II diabetes mellitus_Homo sapiens_hsa049300.44473293
124Amphetamine addiction_Homo sapiens_hsa050310.44387534
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44301320
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44121861
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43292711
128Hippo signaling pathway_Homo sapiens_hsa043900.43239420
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.42761030
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42688912
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42216451
132Non-small cell lung cancer_Homo sapiens_hsa052230.41547718
133MicroRNAs in cancer_Homo sapiens_hsa052060.39546459
134Renin secretion_Homo sapiens_hsa049240.39427372
135Proteoglycans in cancer_Homo sapiens_hsa052050.38531767
136N-Glycan biosynthesis_Homo sapiens_hsa005100.38324812
137Cholinergic synapse_Homo sapiens_hsa047250.36926261
138Sulfur metabolism_Homo sapiens_hsa009200.36382468
139Viral myocarditis_Homo sapiens_hsa054160.35619873
140Insulin resistance_Homo sapiens_hsa049310.35113743
141Metabolic pathways_Homo sapiens_hsa011000.35044065
142Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34970973
143Vitamin B6 metabolism_Homo sapiens_hsa007500.34811602
1442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34201957
145Pathways in cancer_Homo sapiens_hsa052000.33620472
146Fatty acid degradation_Homo sapiens_hsa000710.33614550
147Glutamatergic synapse_Homo sapiens_hsa047240.32215800
148Nicotine addiction_Homo sapiens_hsa050330.31881180
149Purine metabolism_Homo sapiens_hsa002300.31634471
150Alcoholism_Homo sapiens_hsa050340.30856059
151T cell receptor signaling pathway_Homo sapiens_hsa046600.30567273
152Apoptosis_Homo sapiens_hsa042100.29799345
153Endometrial cancer_Homo sapiens_hsa052130.29699120
154Lysosome_Homo sapiens_hsa041420.29048596
155Measles_Homo sapiens_hsa051620.29045192
156Inositol phosphate metabolism_Homo sapiens_hsa005620.28864710
157Phospholipase D signaling pathway_Homo sapiens_hsa040720.28810340
158cAMP signaling pathway_Homo sapiens_hsa040240.28147921
159Hepatitis B_Homo sapiens_hsa051610.28133528
160Steroid hormone biosynthesis_Homo sapiens_hsa001400.27665003
161Calcium signaling pathway_Homo sapiens_hsa040200.26411055
162NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26400489
163Legionellosis_Homo sapiens_hsa051340.25702191
164Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25546325
165Fat digestion and absorption_Homo sapiens_hsa049750.24779892
166AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24231448
167Hematopoietic cell lineage_Homo sapiens_hsa046400.23432386
168Adherens junction_Homo sapiens_hsa045200.23110431
169Epstein-Barr virus infection_Homo sapiens_hsa051690.21258174
170Glycosaminoglycan degradation_Homo sapiens_hsa005310.20853137
171Basal transcription factors_Homo sapiens_hsa030220.20451275
172beta-Alanine metabolism_Homo sapiens_hsa004100.19753632
173Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.19674240
174Influenza A_Homo sapiens_hsa051640.18048386

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