MAML1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)6.55151760
2embryonic process involved in female pregnancy (GO:0060136)6.31884699
3regulation of integrin activation (GO:0033623)5.24327706
4establishment of apical/basal cell polarity (GO:0035089)4.82291395
5positive regulation of protein homooligomerization (GO:0032464)4.76739129
6proline metabolic process (GO:0006560)4.58795340
7transcription from mitochondrial promoter (GO:0006390)4.50722523
8replication fork processing (GO:0031297)4.25071883
9negative regulation of erythrocyte differentiation (GO:0045647)4.21818118
10embryonic placenta development (GO:0001892)4.18798234
11regulation of translational fidelity (GO:0006450)4.08117284
12regulation of protein homooligomerization (GO:0032462)4.01992578
13regulation of RNA export from nucleus (GO:0046831)3.94397687
14establishment of monopolar cell polarity (GO:0061162)3.93150690
15establishment or maintenance of monopolar cell polarity (GO:0061339)3.93150690
16mitotic G1 DNA damage checkpoint (GO:0031571)3.88215812
17positive regulation of gamma-delta T cell activation (GO:0046645)3.85180646
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.80385046
19positive regulation by organism of defense response of other organism involved in symbiotic interact3.80385046
20modulation by symbiont of host immune response (GO:0052553)3.80385046
21positive regulation by symbiont of host defense response (GO:0052509)3.80385046
22modulation by symbiont of host defense response (GO:0052031)3.80385046
23modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.80385046
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.79184484
25negative regulation of cell killing (GO:0031342)3.79184484
26histone H3-K36 demethylation (GO:0070544)3.71935288
273-UTR-mediated mRNA stabilization (GO:0070935)3.64607715
28apoptotic process involved in morphogenesis (GO:0060561)3.62794697
29regulation of sister chromatid cohesion (GO:0007063)3.60561994
30maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.58202161
31G1 DNA damage checkpoint (GO:0044783)3.54952583
32dosage compensation (GO:0007549)3.50686059
33negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.50031741
34pre-miRNA processing (GO:0031054)3.49902199
35mitotic G1/S transition checkpoint (GO:0044819)3.48763536
36positive regulation by host of viral transcription (GO:0043923)3.48517908
37positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.43380531
38trophectodermal cell differentiation (GO:0001829)3.41124561
39oxidative demethylation (GO:0070989)3.39433866
40response to muramyl dipeptide (GO:0032495)3.36123173
41positive regulation of protein oligomerization (GO:0032461)3.35366150
42mitochondrial DNA metabolic process (GO:0032042)3.35264606
43anatomical structure regression (GO:0060033)3.34690169
44regulation of NFAT protein import into nucleus (GO:0051532)3.33596200
45antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.28700179
46mRNA cleavage (GO:0006379)3.28221328
47embryonic camera-type eye development (GO:0031076)3.26888305
48negative regulation of cell cycle arrest (GO:0071157)3.25006120
49face development (GO:0060324)3.22341662
50response to peptidoglycan (GO:0032494)3.21711432
51positive regulation of mitotic sister chromatid separation (GO:1901970)3.21682894
52positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.21682894
53positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.21682894
54regulation of gamma-delta T cell activation (GO:0046643)3.20562292
55cellular response to zinc ion (GO:0071294)3.19807908
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.17278915
57leukocyte aggregation (GO:0070486)3.16662680
58negative regulation of fatty acid biosynthetic process (GO:0045717)3.15914730
59antigen processing and presentation of endogenous antigen (GO:0019883)3.13692679
60positive thymic T cell selection (GO:0045059)3.10539059
61spliceosomal tri-snRNP complex assembly (GO:0000244)3.09594547
62regulation of nucleobase-containing compound transport (GO:0032239)3.09328220
63detection of other organism (GO:0098543)3.08665802
64regulation of hippo signaling (GO:0035330)3.08005627
65regulation of gamma-delta T cell differentiation (GO:0045586)3.07114575
66thymic T cell selection (GO:0045061)3.06774834
67antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.05685075
68negative regulation of mRNA processing (GO:0050686)3.04388535
69somatic diversification of immune receptors via somatic mutation (GO:0002566)3.02987214
70somatic hypermutation of immunoglobulin genes (GO:0016446)3.02987214
71DNA strand renaturation (GO:0000733)3.01830590
72RNA stabilization (GO:0043489)3.00261581
73mRNA stabilization (GO:0048255)3.00261581
74epithelial cell differentiation involved in prostate gland development (GO:0060742)2.99482264
75nodal signaling pathway (GO:0038092)2.99481056
76positive regulation of Cdc42 GTPase activity (GO:0043089)2.99346170
77negative regulation of myotube differentiation (GO:0010832)2.96179270
78detection of bacterium (GO:0016045)2.95945220
79protein localization to endosome (GO:0036010)2.93858974
80macrophage activation involved in immune response (GO:0002281)2.93424687
81negative regulation of RNA splicing (GO:0033119)2.92286239
82regulation of gene silencing by RNA (GO:0060966)2.91410575
83regulation of posttranscriptional gene silencing (GO:0060147)2.91410575
84regulation of gene silencing by miRNA (GO:0060964)2.91410575
85poly(A)+ mRNA export from nucleus (GO:0016973)2.89081155
86regulation of chromatin binding (GO:0035561)2.88602797
87regulation of histone H3-K27 methylation (GO:0061085)2.86923027
88convergent extension (GO:0060026)2.86652892
89adherens junction assembly (GO:0034333)2.86393374
90focal adhesion assembly (GO:0048041)2.85785797
91cell-substrate adherens junction assembly (GO:0007045)2.85785797
92mannose metabolic process (GO:0006013)2.84782710
93intracellular estrogen receptor signaling pathway (GO:0030520)2.84598989
94DNA topological change (GO:0006265)2.82049214
95embryonic eye morphogenesis (GO:0048048)2.80116342
96regulation of protein oligomerization (GO:0032459)2.79882058
97negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.77908089
98histone H4-K12 acetylation (GO:0043983)2.77820418
99heterochromatin organization (GO:0070828)2.76580428
100negative regulation of JAK-STAT cascade (GO:0046426)2.75996834
101regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.74838895
102negative regulation of chondrocyte differentiation (GO:0032331)2.74408766
103formation of translation preinitiation complex (GO:0001731)2.73992131
104negative regulation of stress fiber assembly (GO:0051497)2.73936591
105regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.71988355
106cellular response to virus (GO:0098586)2.71887130
107base-excision repair (GO:0006284)2.70171420
108apoptotic process involved in development (GO:1902742)2.69408855
109negative thymic T cell selection (GO:0045060)2.69062449
110histone lysine demethylation (GO:0070076)2.68112679
111response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.67386984
112response to host (GO:0075136)2.67386984
113response to host defenses (GO:0052200)2.67386984
114detection of external biotic stimulus (GO:0098581)2.65911370
115positive regulation of developmental pigmentation (GO:0048087)2.65678088
116T cell selection (GO:0045058)2.64910525
117detection of molecule of bacterial origin (GO:0032490)2.64280955
118negative regulation of Ras GTPase activity (GO:0034261)2.63778927
119regulation of interferon-beta biosynthetic process (GO:0045357)2.61372214
120positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.60801320
121regulation of type I interferon-mediated signaling pathway (GO:0060338)2.59368455
122activation of Rac GTPase activity (GO:0032863)2.59039098
123positive regulation of SMAD protein import into nucleus (GO:0060391)2.58988969
124maternal placenta development (GO:0001893)2.58887419
125negative regulation of cartilage development (GO:0061037)2.58751526
126negative regulation of mRNA metabolic process (GO:1903312)2.58509627
127protein heterotrimerization (GO:0070208)2.57869904
128planar cell polarity pathway involved in neural tube closure (GO:0090179)2.57204268
129glutamine family amino acid biosynthetic process (GO:0009084)2.56611703
130regulation of podosome assembly (GO:0071801)2.55921294
131hippo signaling (GO:0035329)2.55793026
132positive regulation of chromosome segregation (GO:0051984)2.55766706
133germinal center formation (GO:0002467)2.55166600
134polarized epithelial cell differentiation (GO:0030859)2.54846965
135antigen processing and presentation via MHC class Ib (GO:0002475)2.54625207
136negative regulation of toll-like receptor signaling pathway (GO:0034122)2.54512707
137negative regulation of protein oligomerization (GO:0032460)2.53685827
138retinoic acid receptor signaling pathway (GO:0048384)2.52561093
139cellular response to ATP (GO:0071318)2.52468465
140nuclear pore complex assembly (GO:0051292)2.51814010
141histone demethylation (GO:0016577)2.51641672
142detection of biotic stimulus (GO:0009595)2.50628738
143negative T cell selection (GO:0043383)2.50549583
144modulation by symbiont of host cellular process (GO:0044068)2.49246179
145regulation of necroptotic process (GO:0060544)2.47980565
146response to host immune response (GO:0052572)2.47524913
147response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.47524913
148meiotic chromosome segregation (GO:0045132)2.47054791
149response to laminar fluid shear stress (GO:0034616)2.47027040
150glial cell migration (GO:0008347)2.46817428
151positive T cell selection (GO:0043368)2.46611288
152regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.46487898
153response to interleukin-15 (GO:0070672)2.46394834
154negative regulation of glial cell proliferation (GO:0060253)2.46053887
155histone mRNA catabolic process (GO:0071044)2.45861522
156glandular epithelial cell development (GO:0002068)2.45136195
157positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.45101207
158labyrinthine layer development (GO:0060711)2.43511619
159modulation by virus of host process (GO:0019054)2.43230274
160anterior/posterior axis specification, embryo (GO:0008595)2.42394164
161cellular response to epidermal growth factor stimulus (GO:0071364)2.42210600
162hypotonic response (GO:0006971)2.41321249
163regulation of DNA damage checkpoint (GO:2000001)2.40290834
164negative regulation of histone methylation (GO:0031061)2.40253039
165bone morphogenesis (GO:0060349)2.39795626
166regulation of SMAD protein import into nucleus (GO:0060390)2.38930234
167neural tube closure (GO:0001843)2.38094150
168negative regulation of interleukin-12 production (GO:0032695)2.37958564
169regulation of B cell receptor signaling pathway (GO:0050855)2.37544798
170positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.37467901
171positive regulation of lamellipodium assembly (GO:0010592)2.37164164
172regulation of mammary gland epithelial cell proliferation (GO:0033599)2.37107768
173paraxial mesoderm development (GO:0048339)2.36970522
174DNA deamination (GO:0045006)2.36526127
175regulation of cholesterol homeostasis (GO:2000188)2.35619987
176mitotic chromosome condensation (GO:0007076)2.35212669
177histone H3-K9 demethylation (GO:0033169)2.33660097
178regulation of leukocyte degranulation (GO:0043300)2.32229737
179cellular extravasation (GO:0045123)2.31729108
180positive regulation of histone deacetylation (GO:0031065)2.31356165
181negative regulation of viral release from host cell (GO:1902187)2.27609629
182embryonic camera-type eye morphogenesis (GO:0048596)2.26490647
183histone H4 deacetylation (GO:0070933)2.25562584
184DNA unwinding involved in DNA replication (GO:0006268)2.25108718
185stress fiber assembly (GO:0043149)2.24838188
186regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.23551415

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.28529182
2E2F7_22180533_ChIP-Seq_HELA_Human3.06882765
3MYC_22102868_ChIP-Seq_BL_Human2.98578627
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.90779385
5VDR_21846776_ChIP-Seq_THP-1_Human2.90107811
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.71431350
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.63481292
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.41215474
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.40916277
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.31296845
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.12732833
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.09363417
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.09363417
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.09363417
15KDM2B_26808549_Chip-Seq_DND41_Human2.05168202
16KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.03098782
17TCF7_22412390_ChIP-Seq_EML_Mouse2.01413177
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.00271866
19KDM2B_26808549_Chip-Seq_SUP-B15_Human1.99859205
20ELK3_25401928_ChIP-Seq_HUVEC_Human1.99561932
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.99233031
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.93162290
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.85569172
24DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.82214772
25LXR_22292898_ChIP-Seq_THP-1_Human1.79574083
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76795297
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.76069197
28MAF_26560356_Chip-Seq_TH1_Human1.72260152
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.69109675
30RACK7_27058665_Chip-Seq_MCF-7_Human1.66687278
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65762941
32SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.65625127
33KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.64522598
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61435078
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.58423588
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.55861069
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55420380
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54795619
39ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54407435
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53859260
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52668353
42UTX_26944678_Chip-Seq_JUKART_Human1.51756190
43TCF3_18692474_ChIP-Seq_MEFs_Mouse1.50854990
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50293293
45TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.50026669
46SCL_19346495_ChIP-Seq_HPC-7_Human1.49932475
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46792056
48P300_27058665_Chip-Seq_ZR-75-30cells_Human1.45796662
49POU5F1_16518401_ChIP-PET_MESCs_Mouse1.44368957
50STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.43191865
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.41829577
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40592770
53KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39932138
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39670150
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.38649975
56* VDR_24763502_ChIP-Seq_THP-1_Human1.37751087
57* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.37585284
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36262611
59MYC_18555785_ChIP-Seq_MESCs_Mouse1.36025124
60* SPI1_23127762_ChIP-Seq_K562_Human1.33546918
61FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33422789
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32153346
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31472059
64* NANOG_21062744_ChIP-ChIP_HESCs_Human1.30864452
65* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30469802
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30385358
67RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29958141
68IRF8_22096565_ChIP-ChIP_GC-B_Human1.29300567
69ZNF263_19887448_ChIP-Seq_K562_Human1.28193005
70CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.28158479
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28085467
72* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26362932
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.26092820
74RUNX1_27514584_Chip-Seq_MCF-7_Human1.24835625
75NCOR1_26117541_ChIP-Seq_K562_Human1.24309890
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24018356
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23794490
78EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23659412
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.21212929
80CREB1_26743006_Chip-Seq_LNCaP_Human1.19456729
81ATF3_27146783_Chip-Seq_COLON_Human1.19336970
82* P68_20966046_ChIP-Seq_HELA_Human1.18732414
83SA1_27219007_Chip-Seq_ERYTHROID_Human1.17672849
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17445349
85TP63_19390658_ChIP-ChIP_HaCaT_Human1.16809024
86STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.16123468
87* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.16041680
88NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.15901499
89MYB_26560356_Chip-Seq_TH1_Human1.15653268
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15306770
91MAF_26560356_Chip-Seq_TH2_Human1.14325827
92PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13786083
93RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13307840
94TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13269897
95MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12996051
96SPI1_23547873_ChIP-Seq_NB4_Human1.12652057
97RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12578299
98* SMC4_20622854_ChIP-Seq_HELA_Human1.12355839
99KDM2B_26808549_Chip-Seq_K562_Human1.11893439
100NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11517379
101CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11148426
102* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10241799
103PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09808863
104ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09789873
105STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09646131
106RXR_22158963_ChIP-Seq_LIVER_Mouse1.09571227
107RUNX_20019798_ChIP-Seq_JUKART_Human1.07963687
108TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07384820
109IRF8_27001747_Chip-Seq_BMDM_Mouse1.06565060
110MYB_26560356_Chip-Seq_TH2_Human1.06325906
111TFEB_21752829_ChIP-Seq_HELA_Human1.05771454
112CLOCK_20551151_ChIP-Seq_293T_Human1.05476660
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04990048
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04217995
115CHD1_26751641_Chip-Seq_LNCaP_Human1.03197244
116* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01152046
117* RUNX1_22412390_ChIP-Seq_EML_Mouse1.00872779
118GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00651029
119TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99842054
120TRIM28_21343339_ChIP-Seq_HEK293_Human0.99821460
121CIITA_25753668_ChIP-Seq_RAJI_Human0.98666816
122CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97748040
123* TET1_21451524_ChIP-Seq_MESCs_Mouse0.97374615
124RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97309245
125MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96663390
126EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96519608
127SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96163484
128KDM5A_27292631_Chip-Seq_BREAST_Human0.96036761
129PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96001005
130SALL1_21062744_ChIP-ChIP_HESCs_Human0.95902753
131* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95879529
132MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95754431
133NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95655143
134BP1_19119308_ChIP-ChIP_Hs578T_Human0.95614316
135ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95354022
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94779800
137E2F1_21310950_ChIP-Seq_MCF-7_Human0.94676865
138TP53_22127205_ChIP-Seq_IMR90_Human0.94443923

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow3.91989612
2MP0008057_abnormal_DNA_replication3.40636692
3MP0005076_abnormal_cell_differentiation2.86725736
4MP0003436_decreased_susceptibility_to2.79921045
5MP0010030_abnormal_orbit_morphology2.70304116
6MP0003705_abnormal_hypodermis_morpholog2.66665752
7MP0010352_gastrointestinal_tract_polyps2.57913518
8MP0005451_abnormal_body_composition2.41056882
9MP0002009_preneoplasia2.30043711
10MP0005409_darkened_coat_color2.18532986
11MP0005397_hematopoietic_system_phenotyp2.11508517
12MP0001545_abnormal_hematopoietic_system2.11508517
13MP0008260_abnormal_autophagy2.04024039
14MP0004233_abnormal_muscle_weight1.92090202
15MP0003724_increased_susceptibility_to1.79086543
16MP0004858_abnormal_nervous_system1.78952453
17MP0003566_abnormal_cell_adhesion1.73448883
18MP0003453_abnormal_keratinocyte_physiol1.72340315
19MP0000685_abnormal_immune_system1.64599044
20MP0005171_absent_coat_pigmentation1.64222762
21MP0004381_abnormal_hair_follicle1.63758686
22MP0002086_abnormal_extraembryonic_tissu1.60130002
23MP0003890_abnormal_embryonic-extraembry1.54950308
24MP0002419_abnormal_innate_immunity1.52591745
25MP0001835_abnormal_antigen_presentation1.52183048
26MP0005023_abnormal_wound_healing1.49387591
27MP0009053_abnormal_anal_canal1.48564043
28MP0003283_abnormal_digestive_organ1.48459768
29MP0003567_abnormal_fetal_cardiomyocyte1.45902239
30MP0002166_altered_tumor_susceptibility1.45901447
31* MP0004197_abnormal_fetal_growth/weight/1.44587989
32MP0000858_altered_metastatic_potential1.43755328
33MP0008438_abnormal_cutaneous_collagen1.42051267
34MP0002084_abnormal_developmental_patter1.41195437
35MP0005025_abnormal_response_to1.40312861
36MP0005000_abnormal_immune_tolerance1.40168792
37MP0010307_abnormal_tumor_latency1.39867947
38MP0001697_abnormal_embryo_size1.36239115
39MP0010094_abnormal_chromosome_stability1.35679154
40MP0002282_abnormal_trachea_morphology1.33294527
41MP0002420_abnormal_adaptive_immunity1.32908855
42MP0003119_abnormal_digestive_system1.32904438
43MP0001819_abnormal_immune_cell1.32719030
44MP0003191_abnormal_cellular_cholesterol1.32605118
45MP0000537_abnormal_urethra_morphology1.31390667
46MP0005380_embryogenesis_phenotype1.31362544
47MP0001672_abnormal_embryogenesis/_devel1.31362544
48MP0000490_abnormal_crypts_of1.30510856
49MP0002085_abnormal_embryonic_tissue1.28226932
50MP0002723_abnormal_immune_serum1.27308986
51MP0002452_abnormal_antigen_presenting1.26979431
52MP0004264_abnormal_extraembryonic_tissu1.26554467
53MP0002060_abnormal_skin_morphology1.26396576
54MP0003984_embryonic_growth_retardation1.25006940
55MP0003828_pulmonary_edema1.24236273
56MP0002088_abnormal_embryonic_growth/wei1.23656429
57MP0005666_abnormal_adipose_tissue1.23185061
58MP0001293_anophthalmia1.22932300
59MP0000350_abnormal_cell_proliferation1.22690028
60MP0005387_immune_system_phenotype1.22136911
61MP0001790_abnormal_immune_system1.22136911
62MP0004957_abnormal_blastocyst_morpholog1.21576606
63MP0002653_abnormal_ependyma_morphology1.21490291
64MP0000733_abnormal_muscle_development1.20917690
65MP0001533_abnormal_skeleton_physiology1.20239749
66MP0003172_abnormal_lysosome_physiology1.19757173
67MP0002396_abnormal_hematopoietic_system1.18685584
68* MP0000716_abnormal_immune_system1.16923176
69MP0002405_respiratory_system_inflammati1.16716636
70MP0002249_abnormal_larynx_morphology1.16513274
71MP0004185_abnormal_adipocyte_glucose1.15590436
72MP0003045_fibrosis1.15150435
73MP0008995_early_reproductive_senescence1.13204704
74MP0004808_abnormal_hematopoietic_stem1.12739079
75MP0003077_abnormal_cell_cycle1.12694420
76MP0003111_abnormal_nucleus_morphology1.12568409
77MP0002998_abnormal_bone_remodeling1.12185605
78MP0001730_embryonic_growth_arrest1.08342845
79MP0002932_abnormal_joint_morphology1.07882223
80MP0005621_abnormal_cell_physiology1.05021557
81MP0003300_gastrointestinal_ulcer1.05019515
82MP0000371_diluted_coat_color1.04913829
83* MP0002429_abnormal_blood_cell1.04570102
84MP0003279_aneurysm1.03230695
85MP0010630_abnormal_cardiac_muscle1.02889395
86MP0002925_abnormal_cardiovascular_devel1.02562719
87MP0009333_abnormal_splenocyte_physiolog1.02542614
88MP0003935_abnormal_craniofacial_develop1.02510083
89MP0003091_abnormal_cell_migration1.01326616
90MP0009672_abnormal_birth_weight1.01271229
91MP0002006_tumorigenesis1.00992129
92MP0001915_intracranial_hemorrhage1.00703906
93MP0005508_abnormal_skeleton_morphology1.00537115
94MP0005671_abnormal_response_to0.99667939
95MP0003183_abnormal_peptide_metabolism0.99082853
96MP0002019_abnormal_tumor_incidence0.97602791
97MP0002089_abnormal_postnatal_growth/wei0.97316342
98MP0002111_abnormal_tail_morphology0.95433753
99MP0010234_abnormal_vibrissa_follicle0.94726591
100MP0001851_eye_inflammation0.94494399
101MP0005375_adipose_tissue_phenotype0.94057377
102MP0002080_prenatal_lethality0.93812601
103MP0002877_abnormal_melanocyte_morpholog0.93616375
104MP0003303_peritoneal_inflammation0.91400605
105MP0005174_abnormal_tail_pigmentation0.91305350
106MP0001348_abnormal_lacrimal_gland0.91185960
107MP0004133_heterotaxia0.89905994
108MP0003866_abnormal_defecation0.87937520
109MP0003763_abnormal_thymus_physiology0.87849377
110MP0010155_abnormal_intestine_physiology0.87681448
111MP0000678_abnormal_parathyroid_gland0.87571299
112MP0000432_abnormal_head_morphology0.86985718
113MP0003385_abnormal_body_wall0.86953832
114MP0001340_abnormal_eyelid_morphology0.85925559
115MP0008961_abnormal_basal_metabolism0.85220105
116MP0005058_abnormal_lysosome_morphology0.85115997
117MP0001849_ear_inflammation0.85079848
118MP0003115_abnormal_respiratory_system0.84360482
119MP0002796_impaired_skin_barrier0.82693873
120* MP0002398_abnormal_bone_marrow0.82452047
121MP0005623_abnormal_meninges_morphology0.80742370
122* MP0000703_abnormal_thymus_morphology0.80711411
123MP0009115_abnormal_fat_cell0.80628022
124* MP0000689_abnormal_spleen_morphology0.79788724
125MP0003448_altered_tumor_morphology0.79763426
126MP0002722_abnormal_immune_system0.78682054
127MP0005501_abnormal_skin_physiology0.78186864
128MP0002092_abnormal_eye_morphology0.78020514
129MP0006082_CNS_inflammation0.77929976
130MP0009931_abnormal_skin_appearance0.77718005
131MP0000767_abnormal_smooth_muscle0.77711122
132MP0002697_abnormal_eye_size0.77147391
133MP0005310_abnormal_salivary_gland0.76276385
134MP0000477_abnormal_intestine_morphology0.76234425
135MP0004947_skin_inflammation0.75808241
136MP0006054_spinal_hemorrhage0.75161421
137MP0001800_abnormal_humoral_immune0.74910189
138MP0003755_abnormal_palate_morphology0.74742809
139MP0003786_premature_aging0.74425576
140MP0000470_abnormal_stomach_morphology0.74315723
141MP0001873_stomach_inflammation0.73789170
142MP0003221_abnormal_cardiomyocyte_apopto0.73595609

Predicted human phenotypes

RankGene SetZ-score
1Ulnar bowing (HP:0003031)4.09065591
2Pustule (HP:0200039)3.91964282
3Cerebral aneurysm (HP:0004944)3.86094402
4Rib fusion (HP:0000902)3.84826686
5Eczematoid dermatitis (HP:0000976)3.61282438
6Turricephaly (HP:0000262)3.46119026
7Facial hemangioma (HP:0000329)3.40889414
8Alopecia of scalp (HP:0002293)3.33057097
9Broad face (HP:0000283)3.14682632
10Protrusio acetabuli (HP:0003179)3.08482199
11Annular pancreas (HP:0001734)2.95223422
12Intestinal fistula (HP:0100819)2.94772287
13Coronal craniosynostosis (HP:0004440)2.93844971
14Hyperacusis (HP:0010780)2.90244758
15Poikiloderma (HP:0001029)2.82439000
16Abnormality of the distal phalanx of the thumb (HP:0009617)2.75137440
17Concave nail (HP:0001598)2.73538352
18Rectovaginal fistula (HP:0000143)2.72158804
19Rectal fistula (HP:0100590)2.72158804
20Obstructive sleep apnea (HP:0002870)2.71512917
21Short humerus (HP:0005792)2.68883212
22Polycythemia (HP:0001901)2.66961785
23Increased IgM level (HP:0003496)2.53293811
24Flat acetabular roof (HP:0003180)2.51370391
25Recurrent abscess formation (HP:0002722)2.50729227
26Volvulus (HP:0002580)2.50323191
27Recurrent bacterial skin infections (HP:0005406)2.49186932
28Vaginal fistula (HP:0004320)2.49073476
29Selective tooth agenesis (HP:0001592)2.48412720
30Disproportionate tall stature (HP:0001519)2.47578503
31Hypochromic microcytic anemia (HP:0004840)2.46619858
32Bowed forearm bones (HP:0003956)2.43126209
33Bowing of the arm (HP:0006488)2.43126209
34Aplasia/hypoplasia of the humerus (HP:0006507)2.43073959
35Basal cell carcinoma (HP:0002671)2.41641740
36Cellulitis (HP:0100658)2.40724333
37Congenital hip dislocation (HP:0001374)2.37064430
38Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.35528999
39Vertebral hypoplasia (HP:0008417)2.35528999
40Male infertility (HP:0003251)2.30897575
41Dislocated radial head (HP:0003083)2.29627674
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.29439691
43Short 4th metacarpal (HP:0010044)2.29439691
44Urinary glycosaminoglycan excretion (HP:0003541)2.27814188
45Mucopolysacchariduria (HP:0008155)2.27814188
46Premature skin wrinkling (HP:0100678)2.27018584
47Short 5th finger (HP:0009237)2.25808156
48Myocardial infarction (HP:0001658)2.24216009
49Gastrointestinal infarctions (HP:0005244)2.23172761
50Abnormality of the radial head (HP:0003995)2.17845646
51Shallow orbits (HP:0000586)2.17484659
52Myositis (HP:0100614)2.15484907
53Gingivitis (HP:0000230)2.14950527
54Increased IgE level (HP:0003212)2.14656713
55Squamous cell carcinoma (HP:0002860)2.13800644
56Genu recurvatum (HP:0002816)2.10960638
57Premature rupture of membranes (HP:0001788)2.09767942
58Broad thumb (HP:0011304)2.09530259
59Orthostatic hypotension (HP:0001278)2.09160632
60Vertebral fusion (HP:0002948)2.09056006
61Long palpebral fissure (HP:0000637)2.08170723
62Orchitis (HP:0100796)2.08023118
63Segmental peripheral demyelination/remyelination (HP:0003481)2.07929301
64IgA deficiency (HP:0002720)2.07436737
65Increased number of teeth (HP:0011069)2.03492377
66Subacute progressive viral hepatitis (HP:0006572)2.03374389
67Muscle fibrillation (HP:0010546)2.03102476
68Abnormality of mucopolysaccharide metabolism (HP:0011020)2.03041248
69Abnormality of polysaccharide metabolism (HP:0011012)2.03041248
70Abnormality of glycosaminoglycan metabolism (HP:0004371)2.03041248
71Asymmetry of the thorax (HP:0001555)2.02664474
72Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01551445
73Abnormality of the fingertips (HP:0001211)2.01017382
74Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.99090412
75Thin bony cortex (HP:0002753)1.98301035
76Anteriorly placed anus (HP:0001545)1.98205235
77Joint stiffness (HP:0001387)1.98092722
78Spontaneous hematomas (HP:0007420)1.97087929
79Abnormality of macrophages (HP:0004311)1.96748266
80Tongue fasciculations (HP:0001308)1.95493798
81Abnormality of the columella (HP:0009929)1.94560781
82Colitis (HP:0002583)1.93972093
83Abnormal hemoglobin (HP:0011902)1.93390097
84Hypochromic anemia (HP:0001931)1.92030885
85Spinal cord lesions (HP:0100561)1.91939983
86Syringomyelia (HP:0003396)1.91939983
87Abnormality of the phalanges of the hallux (HP:0010057)1.89735716
88Split hand (HP:0001171)1.89443251
89Abnormal vertebral ossification (HP:0100569)1.89196765
90Persistence of primary teeth (HP:0006335)1.88093017
91Dysmetric saccades (HP:0000641)1.87811179
92Blue sclerae (HP:0000592)1.87650500
93Abnormality of the 4th metacarpal (HP:0010012)1.87387374
94Mitral valve prolapse (HP:0001634)1.87277464
95Aneurysm (HP:0002617)1.86564243
96Dysostosis multiplex (HP:0000943)1.86513839
97Slow saccadic eye movements (HP:0000514)1.86511511
98Gastrointestinal inflammation (HP:0004386)1.85710208
99Recurrent fungal infections (HP:0002841)1.85441011
100Mediastinal lymphadenopathy (HP:0100721)1.84715528
101Recurrent viral infections (HP:0004429)1.84116088
102Germ cell neoplasia (HP:0100728)1.83612700
103Hypotelorism (HP:0000601)1.83170808
104Centrally nucleated skeletal muscle fibers (HP:0003687)1.82986888
105Abnormality of the thoracic spine (HP:0100711)1.82411873
106Broad hallux (HP:0010055)1.80924994
107Broad alveolar ridges (HP:0000187)1.80636526
108Abnormality of male internal genitalia (HP:0000022)1.80381708
109Abnormal number of incisors (HP:0011064)1.80005811
110Peritonitis (HP:0002586)1.79968459
111Ankle contracture (HP:0006466)1.79451892
112Neoplasm of the oral cavity (HP:0100649)1.78750506
113Recurrent gram-negative bacterial infections (HP:0005420)1.78153405
114Increased connective tissue (HP:0009025)1.77220551
115Intestinal atresia (HP:0011100)1.77088987
116Viral hepatitis (HP:0006562)1.76903710
117Heterotopia (HP:0002282)1.76485832
118Arnold-Chiari malformation (HP:0002308)1.75292015
119Coarse hair (HP:0002208)1.75286672
120Hamartoma (HP:0010566)1.75234695
121Aortic aneurysm (HP:0004942)1.74697615
122Broad toe (HP:0001837)1.74560953
123Neonatal hypoglycemia (HP:0001998)1.74144623
124Urethral obstruction (HP:0000796)1.73749563
125Retrobulbar optic neuritis (HP:0100654)1.72752421
126Optic neuritis (HP:0100653)1.72752421
127Patellar aplasia (HP:0006443)1.72715176
128Pancreatic islet-cell hyperplasia (HP:0004510)1.72628020
129Albinism (HP:0001022)1.72203006
130Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.72174515
131Vertebral arch anomaly (HP:0008438)1.72050697
132Abnormality of the aortic arch (HP:0012303)1.71558175
133Hypoplastic ischia (HP:0003175)1.71470826
134Long eyelashes (HP:0000527)1.70826728
135Deep palmar crease (HP:0006191)1.69185232
136Dilatation of the ascending aorta (HP:0005111)1.68695437
137Asymmetric septal hypertrophy (HP:0001670)1.67842508
138Diaphragmatic weakness (HP:0009113)1.67452765
139Astrocytoma (HP:0009592)1.67303870
140Abnormality of the astrocytes (HP:0100707)1.67303870
141Meningitis (HP:0001287)1.67061360
142Hemorrhage of the eye (HP:0011885)1.66787732
143Polygenic inheritance (HP:0010982)1.66727907
144Spondylolisthesis (HP:0003302)1.65422906
145Obstructive lung disease (HP:0006536)1.65397890
146Chronic obstructive pulmonary disease (HP:0006510)1.65397890
147Thin ribs (HP:0000883)1.65381983
148Abnormal platelet volume (HP:0011876)1.64816350
149Increased mean platelet volume (HP:0011877)1.64705944
150Hypotrichosis (HP:0001006)1.64238289
151Patellar dislocation (HP:0002999)1.62902716
152Sparse lateral eyebrow (HP:0005338)1.62681361
153Arterial thrombosis (HP:0004420)1.62376414
154Short chin (HP:0000331)1.62308471
155Distal lower limb amyotrophy (HP:0008944)1.62220495
156Recurrent skin infections (HP:0001581)1.61633528
157Broad palm (HP:0001169)1.60359330
158Trigonocephaly (HP:0000243)1.60208043
159Absent radius (HP:0003974)1.60104306
160Abnormality of the peritoneum (HP:0002585)1.59122705
161Generalized amyotrophy (HP:0003700)1.58608035
162Inflammation of the large intestine (HP:0002037)1.58502706
163Abnormality of the humeroradial joint (HP:0100744)1.58433100
164Mitral regurgitation (HP:0001653)1.57997076
165Narrow palate (HP:0000189)1.57982168
166Metaphyseal cupping (HP:0003021)1.57412647
167Chronic mucocutaneous candidiasis (HP:0002728)1.56280780
168Recurrent cutaneous fungal infections (HP:0011370)1.56280780
169Chest pain (HP:0100749)1.55795988
170Bicuspid aortic valve (HP:0001647)1.55598686
171Bowel incontinence (HP:0002607)1.54920267
172Supernumerary ribs (HP:0005815)1.53667070
173Thoracic kyphosis (HP:0002942)1.52534368
174Abnormality of oral frenula (HP:0000190)1.50681101
175Ankyloglossia (HP:0010296)1.50551359
176Joint laxity (HP:0001388)1.50448314
177Anal stenosis (HP:0002025)1.49326839
178Deep philtrum (HP:0002002)1.47789399
179Increased variability in muscle fiber diameter (HP:0003557)1.47481102
180Pointed chin (HP:0000307)1.47426740
181Rectal prolapse (HP:0002035)1.47070822
182T lymphocytopenia (HP:0005403)1.46984377
183Abnormality of the parietal bone (HP:0002696)1.46910672

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.56212378
2DDR23.92265986
3SMG13.73480310
4PRPF4B3.40710403
5MAPK153.22093015
6MAP3K102.98047268
7MAP3K62.80448603
8CDK122.57756274
9TRIB32.56213973
10PDGFRA2.42023025
11MAP3K112.37115275
12TYRO32.32935651
13BMX2.14944259
14CSK1.97759281
15MATK1.97485199
16RIPK41.94410532
17FGR1.90793110
18LATS11.88908083
19CDK61.86653154
20ERN11.85730573
21PRKD21.83350796
22DYRK1B1.66275668
23IRAK31.61063091
24LATS21.60835056
25EEF2K1.60397894
26PIM11.52990871
27STK101.46925940
28CDK71.43795568
29IRAK41.40544864
30PIM21.40529913
31MAP4K11.38969626
32RIPK11.37401226
33MAP3K131.36965197
34PKN21.35276406
35MTOR1.34189141
36MARK21.32278230
37KSR21.29142777
38MAP3K141.26577749
39STK31.24405551
40SIK11.22631896
41TRPM71.22130909
42YES11.15909756
43DMPK1.11166061
44BLK1.08601269
45GSK3A1.07145830
46PDGFRB1.03963701
47DAPK11.02284727
48UHMK11.02262780
49TNK21.01281547
50MAPK111.00139363
51RPS6KL10.96784410
52RPS6KC10.96784410
53MAP3K10.94776323
54MAP3K30.94293293
55CDK40.93533529
56PTK60.93122597
57TTN0.92468540
58NEK20.91842335
59RPS6KA60.90219260
60IRAK20.89217601
61MAP3K70.88061946
62MAP2K20.86122490
63RPS6KB20.83858100
64HIPK20.83192657
65SIK30.82740704
66PAK40.81170540
67CHUK0.80856102
68CAMK1D0.79447291
69BTK0.78477130
70SGK30.78143889
71CDC42BPA0.77312654
72PTK20.76534127
73FES0.76027436
74FGFR40.75797811
75DYRK30.74694480
76EPHB10.74417283
77PAK20.73356806
78RPS6KA20.73245470
79TGFBR20.71663340
80IKBKE0.71440713
81RET0.71173022
82RPS6KA10.69483378
83FGFR10.69305448
84PDPK10.68936342
85PINK10.68674522
86LRRK20.68657353
87RPS6KA40.67698420
88JAK10.67502444
89TAOK10.66154425
90FLT30.64862984
91CHEK20.63518017
92STK40.60227333
93EPHA20.59158888
94TESK20.59060923
95MAP2K30.57368135
96IKBKB0.57244413
97STK380.56728568
98ZAP700.56681035
99CSF1R0.56396924
100JAK30.55762033
101MAP3K80.54871391
102GRK60.53873253
103ALK0.53285754
104MAPK70.53127855
105PASK0.52345340
106TYK20.52259494
107JAK20.52074246
108EGFR0.51921307
109CDC70.50902881
110CDK90.50191818
111MAPK10.50033826
112BRD40.49317277
113PRKAA10.48452036
114WNK10.48449633
115PDK10.46709694
116IRAK10.45613026
117CDK20.45233981
118PRKD30.44196442
119ITK0.44181386
120MAPKAPK20.43803804
121ATR0.43462769
122FGFR30.43442844
123CAMKK10.43117339
124MELK0.42024183
125TBK10.40711584
126PRKAA20.39703962
127CHEK10.38989815
128CAMK1G0.38947328
129MAPK30.38846692
130PLK10.38442821
131INSR0.38147362
132TAOK20.37420423
133LCK0.36731128
134SIK20.33606684
135HCK0.32286345
136PRKD10.31931259

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000612.99935175
2Base excision repair_Homo sapiens_hsa034102.57890142
3Mismatch repair_Homo sapiens_hsa034302.31068128
4Adherens junction_Homo sapiens_hsa045202.16065397
5Lysine degradation_Homo sapiens_hsa003101.90644692
6mTOR signaling pathway_Homo sapiens_hsa041501.89373130
7Hippo signaling pathway_Homo sapiens_hsa043901.84241197
8Chronic myeloid leukemia_Homo sapiens_hsa052201.83726918
9* Notch signaling pathway_Homo sapiens_hsa043301.80257602
10DNA replication_Homo sapiens_hsa030301.76309547
11Small cell lung cancer_Homo sapiens_hsa052221.65312912
12TGF-beta signaling pathway_Homo sapiens_hsa043501.64830123
13Transcriptional misregulation in cancer_Homo sapiens_hsa052021.63119791
14p53 signaling pathway_Homo sapiens_hsa041151.61399655
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.61354367
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.61306486
17MicroRNAs in cancer_Homo sapiens_hsa052061.61237920
18Bladder cancer_Homo sapiens_hsa052191.57975968
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.57900984
20Basal cell carcinoma_Homo sapiens_hsa052171.53468821
21Hedgehog signaling pathway_Homo sapiens_hsa043401.52004030
22Renal cell carcinoma_Homo sapiens_hsa052111.49978425
23Viral myocarditis_Homo sapiens_hsa054161.44029694
24mRNA surveillance pathway_Homo sapiens_hsa030151.43346906
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.41209934
26Other glycan degradation_Homo sapiens_hsa005111.40163993
27Shigellosis_Homo sapiens_hsa051311.38123669
28Primary immunodeficiency_Homo sapiens_hsa053401.37915327
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.35399470
30Proteoglycans in cancer_Homo sapiens_hsa052051.33918690
31Acute myeloid leukemia_Homo sapiens_hsa052211.31348290
32Longevity regulating pathway - mammal_Homo sapiens_hsa042111.28566426
33Cell cycle_Homo sapiens_hsa041101.27734284
34RNA transport_Homo sapiens_hsa030131.23235214
35Influenza A_Homo sapiens_hsa051641.23206796
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22346689
37Colorectal cancer_Homo sapiens_hsa052101.21652462
38Hepatitis C_Homo sapiens_hsa051601.20386105
39Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20072467
40Focal adhesion_Homo sapiens_hsa045101.18527746
41B cell receptor signaling pathway_Homo sapiens_hsa046621.16550248
42Glioma_Homo sapiens_hsa052141.15147763
43Spliceosome_Homo sapiens_hsa030401.13637237
44Pancreatic cancer_Homo sapiens_hsa052121.13129267
45Viral carcinogenesis_Homo sapiens_hsa052031.11933020
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11932131
47VEGF signaling pathway_Homo sapiens_hsa043701.10529271
48Choline metabolism in cancer_Homo sapiens_hsa052311.07475012
49Tuberculosis_Homo sapiens_hsa051521.06862263
50Hepatitis B_Homo sapiens_hsa051611.06606488
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04810170
52Herpes simplex infection_Homo sapiens_hsa051681.04634725
53HTLV-I infection_Homo sapiens_hsa051661.04424337
54Chemokine signaling pathway_Homo sapiens_hsa040621.03041208
55Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02326555
56Phospholipase D signaling pathway_Homo sapiens_hsa040721.01642404
57Wnt signaling pathway_Homo sapiens_hsa043101.01372921
58Circadian rhythm_Homo sapiens_hsa047100.99854672
59Measles_Homo sapiens_hsa051620.96292359
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.95332631
61Inositol phosphate metabolism_Homo sapiens_hsa005620.93339236
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93131687
63Prostate cancer_Homo sapiens_hsa052150.92840496
64Thyroid cancer_Homo sapiens_hsa052160.91177847
65One carbon pool by folate_Homo sapiens_hsa006700.91003868
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89967251
67Legionellosis_Homo sapiens_hsa051340.88518841
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87773442
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86945904
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.86875058
71Sulfur relay system_Homo sapiens_hsa041220.86191534
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.85468415
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85109368
74Apoptosis_Homo sapiens_hsa042100.84879812
75Osteoclast differentiation_Homo sapiens_hsa043800.84606306
76Estrogen signaling pathway_Homo sapiens_hsa049150.84492694
77Leishmaniasis_Homo sapiens_hsa051400.84335625
78Endometrial cancer_Homo sapiens_hsa052130.84291118
79GnRH signaling pathway_Homo sapiens_hsa049120.83766440
80Malaria_Homo sapiens_hsa051440.82916255
81Dorso-ventral axis formation_Homo sapiens_hsa043200.82568962
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.81846622
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80066870
84AMPK signaling pathway_Homo sapiens_hsa041520.80040741
85Pathways in cancer_Homo sapiens_hsa052000.79897274
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.79759771
87Toxoplasmosis_Homo sapiens_hsa051450.77568660
88ECM-receptor interaction_Homo sapiens_hsa045120.76135088
89Nucleotide excision repair_Homo sapiens_hsa034200.74706114
90Biosynthesis of amino acids_Homo sapiens_hsa012300.74385818
91Prion diseases_Homo sapiens_hsa050200.71826610
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.71334173
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.71316688
94Non-small cell lung cancer_Homo sapiens_hsa052230.70832294
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70778584
96Arginine and proline metabolism_Homo sapiens_hsa003300.70487882
97Staphylococcus aureus infection_Homo sapiens_hsa051500.68666306
98Antigen processing and presentation_Homo sapiens_hsa046120.68302283
99Endocytosis_Homo sapiens_hsa041440.67524499
100Insulin resistance_Homo sapiens_hsa049310.66493904
101T cell receptor signaling pathway_Homo sapiens_hsa046600.65451231
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64734682
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.64464396
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63216182
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63088659
106Type II diabetes mellitus_Homo sapiens_hsa049300.62892998
107Fatty acid metabolism_Homo sapiens_hsa012120.62145752
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61905577
109Amoebiasis_Homo sapiens_hsa051460.61418821
110TNF signaling pathway_Homo sapiens_hsa046680.60330456
111Epstein-Barr virus infection_Homo sapiens_hsa051690.59946882
112Arginine biosynthesis_Homo sapiens_hsa002200.59904540
113Rap1 signaling pathway_Homo sapiens_hsa040150.59845010
114Insulin signaling pathway_Homo sapiens_hsa049100.59406261
115Tight junction_Homo sapiens_hsa045300.59006786
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58996303
117HIF-1 signaling pathway_Homo sapiens_hsa040660.58501130
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.58406446
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56450415
120Fanconi anemia pathway_Homo sapiens_hsa034600.54987453
121FoxO signaling pathway_Homo sapiens_hsa040680.54898931
122Salmonella infection_Homo sapiens_hsa051320.54739979
123Graft-versus-host disease_Homo sapiens_hsa053320.54302453
124Pentose phosphate pathway_Homo sapiens_hsa000300.52983685
125Prolactin signaling pathway_Homo sapiens_hsa049170.52960906
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52227228
127Long-term potentiation_Homo sapiens_hsa047200.51994838
128Homologous recombination_Homo sapiens_hsa034400.51355653
129Hematopoietic cell lineage_Homo sapiens_hsa046400.50294656
130Platelet activation_Homo sapiens_hsa046110.50166165
131ErbB signaling pathway_Homo sapiens_hsa040120.49973979
1322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49893111
133MAPK signaling pathway_Homo sapiens_hsa040100.47420420
134Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45266505

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