MAML2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.46954245
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.46954245
3cellular response to interleukin-15 (GO:0071350)4.01097682
4positive regulation of gamma-delta T cell activation (GO:0046645)3.64911521
5facial nerve structural organization (GO:0021612)3.55708998
6response to interleukin-15 (GO:0070672)3.28881733
7detection of molecule of bacterial origin (GO:0032490)3.28605520
8negative T cell selection (GO:0043383)3.13325829
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.12107411
10dermatan sulfate biosynthetic process (GO:0030208)3.08135942
11negative thymic T cell selection (GO:0045060)3.02892911
12dermatan sulfate metabolic process (GO:0030205)2.97785935
13G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.95791034
14regulation of interleukin-12 biosynthetic process (GO:0045075)2.93583710
15lymph node development (GO:0048535)2.92972183
16negative regulation of interleukin-12 production (GO:0032695)2.90555830
17radial glial cell differentiation (GO:0060019)2.89743330
18cell proliferation involved in kidney development (GO:0072111)2.86583711
19lymph vessel development (GO:0001945)2.85805044
20type I interferon signaling pathway (GO:0060337)2.84780725
21cellular response to type I interferon (GO:0071357)2.84780725
22response to type I interferon (GO:0034340)2.84614765
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.84443725
24omega-hydroxylase P450 pathway (GO:0097267)2.84158354
25cellular extravasation (GO:0045123)2.83426563
26outer ear morphogenesis (GO:0042473)2.82308680
27notochord development (GO:0030903)2.81330826
28macrophage activation involved in immune response (GO:0002281)2.80631216
29hypotonic response (GO:0006971)2.77509894
30regulation of B cell receptor signaling pathway (GO:0050855)2.77066210
31positive regulation of interferon-alpha production (GO:0032727)2.76994974
32positive regulation of tolerance induction (GO:0002645)2.76283013
33cell differentiation involved in metanephros development (GO:0072202)2.71896560
34regulation of alpha-beta T cell proliferation (GO:0046640)2.71593091
35mesenchymal cell differentiation involved in kidney development (GO:0072161)2.70976759
36mesenchymal cell differentiation involved in renal system development (GO:2001012)2.70976759
37Notch signaling involved in heart development (GO:0061314)2.70701593
38negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.69947294
39regulation of mesenchymal cell apoptotic process (GO:2001053)2.69477258
40positive regulation of extracellular matrix organization (GO:1903055)2.68969054
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.68410613
42negative regulation of T cell mediated immunity (GO:0002710)2.68288462
43CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.66787860
44interleukin-6-mediated signaling pathway (GO:0070102)2.66301158
45regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.65354908
46regulation of RIG-I signaling pathway (GO:0039535)2.63582431
47interferon-gamma-mediated signaling pathway (GO:0060333)2.62261490
48regulation of T cell tolerance induction (GO:0002664)2.61668911
49germinal center formation (GO:0002467)2.61596499
50response to muramyl dipeptide (GO:0032495)2.60839595
51response to laminar fluid shear stress (GO:0034616)2.60649812
52regulation of pigment cell differentiation (GO:0050932)2.60566313
53regulation of regulatory T cell differentiation (GO:0045589)2.60306799
54regulation of interferon-alpha production (GO:0032647)2.60191008
55positive regulation of alpha-beta T cell proliferation (GO:0046641)2.59167751
56cranial nerve structural organization (GO:0021604)2.57243596
57regulation of tolerance induction (GO:0002643)2.55076413
58mesenchyme morphogenesis (GO:0072132)2.54389919
59negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.54312270
60regulation of interferon-beta biosynthetic process (GO:0045357)2.54206123
61positive regulation of natural killer cell mediated immunity (GO:0002717)2.53808031
62positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.53808031
63regulation of T cell chemotaxis (GO:0010819)2.53674569
64positive regulation of T cell chemotaxis (GO:0010820)2.53674569
65regulation of extracellular matrix disassembly (GO:0010715)2.52143501
66platelet-derived growth factor receptor signaling pathway (GO:0048008)2.51988106
67adenine nucleotide transport (GO:0051503)2.51945019
68cellular response to ethanol (GO:0071361)2.51578215
69B cell proliferation (GO:0042100)2.51552451
70antigen processing and presentation of endogenous antigen (GO:0019883)2.50905599
71regulation of fever generation (GO:0031620)2.50498371
72dendritic cell chemotaxis (GO:0002407)2.50197965
73microglial cell activation (GO:0001774)2.49098452
74glomerulus development (GO:0032835)2.49075953
75interferon-gamma production (GO:0032609)2.48419446
76cell proliferation involved in metanephros development (GO:0072203)2.47811395
77positive regulation of natural killer cell differentiation (GO:0032825)2.47787611
78epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.47364254
79regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.45929389
80antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.45783969
81antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.45783969
82negative regulation of osteoblast proliferation (GO:0033689)2.43121508
83metanephric mesenchyme development (GO:0072075)2.42931792
84negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.42907471
85positive regulation of smooth muscle cell migration (GO:0014911)2.42607428
86regulation of non-canonical Wnt signaling pathway (GO:2000050)2.42436723
87response to peptidoglycan (GO:0032494)2.41638433
88myeloid dendritic cell activation (GO:0001773)2.41374513
89modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.41138856
90positive regulation by organism of defense response of other organism involved in symbiotic interact2.41138856
91modulation by symbiont of host immune response (GO:0052553)2.41138856
92positive regulation by symbiont of host defense response (GO:0052509)2.41138856
93modulation by symbiont of host defense response (GO:0052031)2.41138856
94modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.41138856
95positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.40914482
96neural tube formation (GO:0001841)2.38820377
97positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.36621065
98retina vasculature morphogenesis in camera-type eye (GO:0061299)2.35754005
99keratan sulfate biosynthetic process (GO:0018146)2.35393920
100purinergic nucleotide receptor signaling pathway (GO:0035590)2.35363220
101negative regulation of viral genome replication (GO:0045071)2.34933283
102cellular response to exogenous dsRNA (GO:0071360)2.34483316
103detection of external biotic stimulus (GO:0098581)2.34444671
104positive regulation of response to biotic stimulus (GO:0002833)2.34410662
105kidney mesenchyme development (GO:0072074)2.33834987
106tolerance induction (GO:0002507)2.32062943
107mesenchymal cell development (GO:0014031)2.31704627
108positive regulation of heat generation (GO:0031652)2.31600134
109regulation of interleukin-8 secretion (GO:2000482)2.31451627
110regulation of gamma-delta T cell activation (GO:0046643)2.31348097
111skin morphogenesis (GO:0043589)2.31271894
112positive regulation of monocyte chemotaxis (GO:0090026)2.29668796
113regulation of macrophage cytokine production (GO:0010935)2.29660653
114activated T cell proliferation (GO:0050798)2.29512914
115regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.28901792
116substrate-dependent cell migration (GO:0006929)2.28886936
117regulation of natural killer cell mediated immunity (GO:0002715)2.28455735
118regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.28455735
119regulation of gamma-delta T cell differentiation (GO:0045586)2.28214342
120regulation of vitamin D biosynthetic process (GO:0060556)2.28186516
121purine ribonucleotide transport (GO:0015868)2.27053627
122positive regulation of interleukin-12 production (GO:0032735)2.26860457
123endocardial cushion morphogenesis (GO:0003203)2.26769031
124positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.26571603
125mature B cell differentiation (GO:0002335)2.26421295
126T cell lineage commitment (GO:0002360)2.25862525
127response to interferon-alpha (GO:0035455)2.25644527
128response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.25489843
129response to host (GO:0075136)2.25489843
130response to host defenses (GO:0052200)2.25489843
131lipopolysaccharide-mediated signaling pathway (GO:0031663)2.25028720
132T cell differentiation (GO:0030217)2.24864779
133regulation of T cell receptor signaling pathway (GO:0050856)2.24833847
134definitive hemopoiesis (GO:0060216)2.24661424
135histone H3-K36 demethylation (GO:0070544)2.24555690
136positive regulation of astrocyte differentiation (GO:0048711)2.24391020
137leukocyte aggregation (GO:0070486)2.22846523
138chondroitin sulfate biosynthetic process (GO:0030206)2.22351202
139regulation of dendritic cell antigen processing and presentation (GO:0002604)2.21964754
140pericardium development (GO:0060039)2.20906489
141positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.20811943
142JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.19225690
143negative regulation of anoikis (GO:2000811)2.18580830
144pathway-restricted SMAD protein phosphorylation (GO:0060389)2.17565792
145T cell migration (GO:0072678)2.15768843
146macrophage activation (GO:0042116)2.15015849
147regulation of T-helper 2 cell differentiation (GO:0045628)2.14803267
148negative regulation of cytokine production involved in immune response (GO:0002719)2.14725364
149positive T cell selection (GO:0043368)2.14136678
150positive regulation of cellular amide metabolic process (GO:0034250)2.12793731
151detection of other organism (GO:0098543)2.12523660
152myeloid dendritic cell differentiation (GO:0043011)2.12055826
153negative regulation of lymphocyte mediated immunity (GO:0002707)2.10854389
154regulation of extracellular matrix organization (GO:1903053)2.10569900
155regulation of T-helper 1 cell differentiation (GO:0045625)2.10326183
156detection of biotic stimulus (GO:0009595)2.10173418
157embryonic process involved in female pregnancy (GO:0060136)2.09762212
158membrane raft organization (GO:0031579)2.08419281
159T-helper 1 type immune response (GO:0042088)2.07746220
160positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.06558669
161positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.05913557
162positive regulation of receptor recycling (GO:0001921)2.05684079
163regulation of necroptotic process (GO:0060544)2.05561118
164T cell selection (GO:0045058)2.05469188
165cellular response to interferon-alpha (GO:0035457)2.05164984
166response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.05070358
167response to host immune response (GO:0052572)2.05070358
168protein localization to endosome (GO:0036010)2.04118682

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.31288944
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.15604236
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.67801193
4* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.21067571
5IRF8_22096565_ChIP-ChIP_GC-B_Human4.14595042
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.33454447
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.85559380
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.82606581
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.72677753
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.62486151
11RUNX_20019798_ChIP-Seq_JUKART_Human2.56280082
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52657656
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.26730312
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.19052695
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.04908000
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.04400749
17* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.02745934
18IRF8_27001747_Chip-Seq_BMDM_Mouse1.91835107
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.84767905
20VDR_24787735_ChIP-Seq_THP-1_Human1.81737242
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78138998
22CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.75818240
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.72800406
24* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.71603911
25* SCL_19346495_ChIP-Seq_HPC-7_Human1.70473739
26* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69198740
27* AR_21572438_ChIP-Seq_LNCaP_Human1.67744212
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.67495032
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.64796753
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.63529818
31MYB_26560356_Chip-Seq_TH2_Human1.59306082
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.58658639
33TP53_16413492_ChIP-PET_HCT116_Human1.56829586
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.56716735
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53871694
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52512857
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51603696
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49465468
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.49102783
40SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47797959
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46669836
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45426131
43TP53_18474530_ChIP-ChIP_U2OS_Human1.45290745
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.42684408
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.41611295
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41424708
47BRD4_25478319_ChIP-Seq_HGPS_Human1.40313736
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.38655703
49GBX2_23144817_ChIP-Seq_PC3_Human1.36615217
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.36360608
51* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35316453
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.33631005
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.33348439
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.33348439
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32897389
56SPI1_23127762_ChIP-Seq_K562_Human1.32551507
57EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31923058
58AHR_22903824_ChIP-Seq_MCF-7_Human1.31909153
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30959226
60TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.29269228
61JARID2_20064375_ChIP-Seq_MESCs_Mouse1.28861575
62* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.28324991
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.28152620
64CDX2_20551321_ChIP-Seq_CACO-2_Human1.27077661
65GATA1_22025678_ChIP-Seq_K562_Human1.26949850
66CTNNB1_20460455_ChIP-Seq_HCT116_Human1.26889141
67TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.25324010
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.24855285
69* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24605461
70SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24341837
71* MAF_26560356_Chip-Seq_TH1_Human1.23569319
72PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22765152
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22573937
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.21286089
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20924658
76NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20728106
77SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17979939
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17382954
79CJUN_26792858_Chip-Seq_BT549_Human1.16337505
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15245234
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15115567
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.13573440
83MYB_26560356_Chip-Seq_TH1_Human1.11229709
84CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09971301
85VDR_24763502_ChIP-Seq_THP-1_Human1.09580911
86* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08218243
87* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08218243
88TP53_20018659_ChIP-ChIP_R1E_Mouse1.08104457
89JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07525549
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07318849
91Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07258234
92* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06458546
93NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06189672
94JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05124550
95EZH2_27304074_Chip-Seq_ESCs_Mouse1.04833753
96ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04816089
97JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04543054
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03585283
99RXR_22108803_ChIP-Seq_LS180_Human1.02580275
100FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01452031
101NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00962377
102PU_27001747_Chip-Seq_BMDM_Mouse1.00692805
103PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99957589
104EZH2_22144423_ChIP-Seq_EOC_Human0.99155021
105BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99100452
106* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98437979
107TCF7_22412390_ChIP-Seq_EML_Mouse0.97566068
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96692069
109E2F1_18555785_Chip-Seq_ESCs_Mouse0.96519097
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96162458
111* TP63_23658742_ChIP-Seq_EP156T_Human0.94291832
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93799941
113TBX20_22328084_ChIP-Seq_HEART_Mouse0.93599506
114TBX20_22080862_ChIP-Seq_HEART_Mouse0.93599506
115* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93476721
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93304420
117SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92937024
118* FOXA2_19822575_ChIP-Seq_HepG2_Human0.92485034
119RNF2_27304074_Chip-Seq_ESCs_Mouse0.90880819
120RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.90703057
121SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90652169
122WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89873061
123P300_19829295_ChIP-Seq_ESCs_Human0.89183187
124PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88655331
125NFE2_27457419_Chip-Seq_LIVER_Mouse0.88144774
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87491594
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85816852
128* PIAS1_25552417_ChIP-Seq_VCAP_Human0.85807195
129KDM2B_26808549_Chip-Seq_JURKAT_Human0.85273097
130ESR1_20079471_ChIP-ChIP_T-47D_Human0.84372562
131PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84372186
132KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.84266966
133GATA1_19941826_ChIP-Seq_K562_Human0.83895150
134P53_22387025_ChIP-Seq_ESCs_Mouse0.83261784
135TCF4_18268006_ChIP-ChIP_LS174T_Human0.83176218
136LXR_22158963_ChIP-Seq_LIVER_Mouse0.81767597
137NFI_21473784_ChIP-Seq_ESCs_Mouse0.81182350
138DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.80919516
139GATA3_27048872_Chip-Seq_THYMUS_Human0.80655404
140SA1_22415368_ChIP-Seq_MEFs_Mouse0.79803658
141* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.79521499
142* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.79521499
143NMYC_18555785_Chip-Seq_ESCs_Mouse0.78310244
144TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.77571678
145BCAT_22108803_ChIP-Seq_LS180_Human0.77325531
146SOX2_20726797_ChIP-Seq_SW620_Human0.77313357

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.54748270
2MP0003303_peritoneal_inflammation3.37234462
3MP0003136_yellow_coat_color3.21275059
4MP0001835_abnormal_antigen_presentation2.75963497
5MP0002009_preneoplasia2.73982663
6MP0005409_darkened_coat_color2.47376459
7MP0003279_aneurysm2.32461964
8MP0003705_abnormal_hypodermis_morpholog2.30623251
9MP0005671_abnormal_response_to2.27269229
10MP0005503_abnormal_tendon_morphology2.24094255
11MP0003763_abnormal_thymus_physiology2.21726722
12MP0003724_increased_susceptibility_to2.17075108
13MP0010368_abnormal_lymphatic_system2.16987931
14MP0009785_altered_susceptibility_to2.13474304
15MP0004381_abnormal_hair_follicle2.12342896
16MP0000685_abnormal_immune_system2.08805819
17MP0000569_abnormal_digit_pigmentation2.02893454
18MP0009379_abnormal_foot_pigmentation2.01650443
19MP0005275_abnormal_skin_tensile1.99772252
20MP0001790_abnormal_immune_system1.96772827
21MP0005387_immune_system_phenotype1.96772827
22MP0008438_abnormal_cutaneous_collagen1.93161774
23MP0001879_abnormal_lymphatic_vessel1.89219014
24MP0000049_abnormal_middle_ear1.86857604
25MP0005164_abnormal_response_to1.83953927
26MP0004947_skin_inflammation1.81059809
27MP0002148_abnormal_hypersensitivity_rea1.79945088
28MP0002249_abnormal_larynx_morphology1.79353851
29MP0009250_abnormal_appendicular_skeleto1.78015527
30MP0003566_abnormal_cell_adhesion1.77832158
31MP0002933_joint_inflammation1.75370331
32MP0004808_abnormal_hematopoietic_stem1.68474922
33MP0001800_abnormal_humoral_immune1.68391594
34MP0002166_altered_tumor_susceptibility1.65937298
35MP0000566_synostosis1.65674281
36MP0008004_abnormal_stomach_pH1.65464967
37MP0002452_abnormal_antigen_presenting1.63358045
38MP0003828_pulmonary_edema1.59189314
39MP0003191_abnormal_cellular_cholesterol1.57594282
40MP0003950_abnormal_plasma_membrane1.56111920
41MP0005000_abnormal_immune_tolerance1.51739919
42MP0001346_abnormal_lacrimal_gland1.49773251
43MP0001851_eye_inflammation1.47859477
44MP0001819_abnormal_immune_cell1.47322806
45MP0002420_abnormal_adaptive_immunity1.46455843
46MP0001958_emphysema1.43978763
47MP0002723_abnormal_immune_serum1.42859867
48MP0002006_tumorigenesis1.42435048
49MP0001853_heart_inflammation1.40874337
50MP0000767_abnormal_smooth_muscle1.39933243
51MP0001188_hyperpigmentation1.39904388
52MP0003690_abnormal_glial_cell1.39859576
53MP0005076_abnormal_cell_differentiation1.38065605
54MP0005025_abnormal_response_to1.36999915
55MP0003436_decreased_susceptibility_to1.36396843
56MP0000372_irregular_coat_pigmentation1.36344462
57MP0010352_gastrointestinal_tract_polyps1.33958621
58MP0003385_abnormal_body_wall1.33497811
59MP0002282_abnormal_trachea_morphology1.33315515
60MP0002419_abnormal_innate_immunity1.33208493
61MP0005171_absent_coat_pigmentation1.30945135
62MP0002398_abnormal_bone_marrow1.28186824
63MP0003453_abnormal_keratinocyte_physiol1.26107695
64MP0002998_abnormal_bone_remodeling1.25061416
65MP0002254_reproductive_system_inflammat1.24069071
66MP0002405_respiratory_system_inflammati1.23837620
67MP0008007_abnormal_cellular_replicative1.20590766
68MP0001915_intracranial_hemorrhage1.18218460
69MP0000716_abnormal_immune_system1.16840121
70MP0009333_abnormal_splenocyte_physiolog1.16100872
71MP0009840_abnormal_foam_cell1.15625404
72MP0000858_altered_metastatic_potential1.15000566
73MP0005390_skeleton_phenotype1.14858381
74MP0000465_gastrointestinal_hemorrhage1.14756887
75MP0001533_abnormal_skeleton_physiology1.14226643
76MP0003045_fibrosis1.14170852
77MP0002396_abnormal_hematopoietic_system1.13049000
78MP0009384_cardiac_valve_regurgitation1.12672703
79MP0000249_abnormal_blood_vessel1.12060383
80MP0004883_abnormal_blood_vessel1.11162787
81MP0003943_abnormal_hepatobiliary_system1.11007325
82MP0000015_abnormal_ear_pigmentation1.10531392
83MP0000703_abnormal_thymus_morphology1.09178796
84MP0005508_abnormal_skeleton_morphology1.08994884
85MP0005595_abnormal_vascular_smooth1.08944040
86MP0005623_abnormal_meninges_morphology1.08549253
87MP0002177_abnormal_outer_ear1.07873656
88MP0001270_distended_abdomen1.07372291
89MP0000428_abnormal_craniofacial_morphol1.05840863
90MP0003172_abnormal_lysosome_physiology1.05233644
91MP0005310_abnormal_salivary_gland1.04619924
92MP0005257_abnormal_intraocular_pressure1.04373729
93MP0001845_abnormal_inflammatory_respons1.03875205
94MP0002722_abnormal_immune_system1.03686312
95MP0006054_spinal_hemorrhage1.03570802
96MP0000604_amyloidosis1.03402139
97MP0000163_abnormal_cartilage_morphology1.01849705
98MP0000689_abnormal_spleen_morphology1.01688086
99MP0002133_abnormal_respiratory_system1.01673886
100MP0005388_respiratory_system_phenotype1.01673886
101MP0003448_altered_tumor_morphology1.01628472
102MP0003942_abnormal_urinary_system1.00967559
103MP0003075_altered_response_to0.97698696
104MP0003091_abnormal_cell_migration0.97366606
105MP0003755_abnormal_palate_morphology0.97345534
106MP0004510_myositis0.96834427
107MP0010155_abnormal_intestine_physiology0.96688113
108MP0001986_abnormal_taste_sensitivity0.96273758
109MP0005023_abnormal_wound_healing0.96256971
110MP0002115_abnormal_skeleton_extremities0.96227142
111MP0000920_abnormal_myelination0.95855253
112MP0000343_altered_response_to0.95380917
113MP0004272_abnormal_basement_membrane0.93985939
114MP0005058_abnormal_lysosome_morphology0.93963480
115MP0002095_abnormal_skin_pigmentation0.91684124
116MP0002168_other_aberrant_phenotype0.90718211
117MP0002429_abnormal_blood_cell0.89614467
118MP0002109_abnormal_limb_morphology0.89336508
119MP0009278_abnormal_bone_marrow0.88661679
120MP0010030_abnormal_orbit_morphology0.88426767
121MP0004130_abnormal_muscle_cell0.88074214
122MP0008789_abnormal_olfactory_epithelium0.87825516
123MP0005397_hematopoietic_system_phenotyp0.87555221
124MP0001545_abnormal_hematopoietic_system0.87555221
125MP0002113_abnormal_skeleton_development0.86186635
126MP0009115_abnormal_fat_cell0.85652212
127MP0006292_abnormal_olfactory_placode0.84802981
128MP0006082_CNS_inflammation0.84328066
129MP0005166_decreased_susceptibility_to0.84194848
130MP0001348_abnormal_lacrimal_gland0.83619795
131MP0009764_decreased_sensitivity_to0.83585019
132MP0008260_abnormal_autophagy0.83582160
133MP0002116_abnormal_craniofacial_bone0.83475966
134MP0002896_abnormal_bone_mineralization0.83019640
135MP0005075_abnormal_melanosome_morpholog0.81818083
136MP0003941_abnormal_skin_development0.81062798
137MP0002332_abnormal_exercise_endurance0.80474305
138MP0005464_abnormal_platelet_physiology0.80248313
139MP0002060_abnormal_skin_morphology0.80239834
140MP0003866_abnormal_defecation0.78591330
141MP0008469_abnormal_protein_level0.77903462
142MP0003795_abnormal_bone_structure0.76320058

Predicted human phenotypes

RankGene SetZ-score
1Arterial tortuosity (HP:0005116)3.74454241
2Spinal cord lesions (HP:0100561)3.49818218
3Syringomyelia (HP:0003396)3.49818218
4Orchitis (HP:0100796)3.31158262
5Retrobulbar optic neuritis (HP:0100654)3.25187594
6Optic neuritis (HP:0100653)3.25187594
7Severe combined immunodeficiency (HP:0004430)3.21405105
8Thyroiditis (HP:0100646)3.15726490
9Pulmonary artery stenosis (HP:0004415)2.89945585
10Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.88303333
11Abnormality of eosinophils (HP:0001879)2.86484600
12Agammaglobulinemia (HP:0004432)2.84562996
13Absent frontal sinuses (HP:0002688)2.73709843
14Abnormality of T cell number (HP:0011839)2.73517825
15Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.71625909
16Peritonitis (HP:0002586)2.71512353
17T lymphocytopenia (HP:0005403)2.71297471
18Neonatal short-limb short stature (HP:0008921)2.63624905
19Short middle phalanx of the 5th finger (HP:0004220)2.56824638
20Dilatation of the ascending aorta (HP:0005111)2.54888125
21Leukocytosis (HP:0001974)2.49506701
22Combined immunodeficiency (HP:0005387)2.48975818
23Abnormality of the frontal sinuses (HP:0002687)2.46165818
24Myositis (HP:0100614)2.44572630
25Recurrent abscess formation (HP:0002722)2.44312699
26Recurrent cutaneous fungal infections (HP:0011370)2.42815655
27Chronic mucocutaneous candidiasis (HP:0002728)2.42815655
28Elevated erythrocyte sedimentation rate (HP:0003565)2.41909202
29Cerebral aneurysm (HP:0004944)2.36906464
30Mesomelia (HP:0003027)2.33290395
31Spontaneous hematomas (HP:0007420)2.32971252
32Basal ganglia calcification (HP:0002135)2.32654684
33Abnormality of the phalanges of the 2nd finger (HP:0009541)2.31798621
34Abnormality of incisor morphology (HP:0011063)2.29960750
35Keratoconjunctivitis sicca (HP:0001097)2.26772329
36Mitral valve prolapse (HP:0001634)2.25612957
37Subacute progressive viral hepatitis (HP:0006572)2.24900759
38Recurrent fungal infections (HP:0002841)2.24721250
39Mediastinal lymphadenopathy (HP:0100721)2.24000033
40Hematochezia (HP:0002573)2.23567363
41Aneurysm (HP:0002617)2.21905579
42Narrow palate (HP:0000189)2.21729712
43Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.21397709
44Overgrowth (HP:0001548)2.20432272
45Panhypogammaglobulinemia (HP:0003139)2.19845277
46Meningitis (HP:0001287)2.19453311
47Abnormality of macrophages (HP:0004311)2.16447340
48Gingivitis (HP:0000230)2.15743859
49Urethral obstruction (HP:0000796)2.15743814
50Cervical subluxation (HP:0003308)2.15675693
51Obstructive sleep apnea (HP:0002870)2.15505881
52Osteolytic defects of the hand bones (HP:0009699)2.15110350
53Osteolytic defects of the phalanges of the hand (HP:0009771)2.15110350
54Vertebral compression fractures (HP:0002953)2.12624446
55Aortic dissection (HP:0002647)2.10882853
56Obstructive lung disease (HP:0006536)2.10317628
57Chronic obstructive pulmonary disease (HP:0006510)2.10317628
58Abnormality of the axillary hair (HP:0100134)2.09847912
59Abnormality of secondary sexual hair (HP:0009888)2.09847912
60Eosinophilia (HP:0001880)2.04234957
61Epiphyseal dysplasia (HP:0002656)1.99795021
62Stomach cancer (HP:0012126)1.99637452
63Decreased skull ossification (HP:0004331)1.99151957
64Keratoconjunctivitis (HP:0001096)1.98728868
65Abnormality of the phalanges of the hallux (HP:0010057)1.98096734
66Abnormality of the phalanges of the 5th finger (HP:0004213)1.98049091
67Abnormality of the parietal bone (HP:0002696)1.97565164
68Broad face (HP:0000283)1.95352194
69Recurrent bacterial skin infections (HP:0005406)1.94389419
70Craniofacial hyperostosis (HP:0004493)1.94361952
71Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.93907812
72Abnormality of the fingertips (HP:0001211)1.93827224
73Aortic aneurysm (HP:0004942)1.92271709
74Biconcave vertebral bodies (HP:0004586)1.91284587
75Stomatitis (HP:0010280)1.89509016
76Long clavicles (HP:0000890)1.89191112
77Abnormality of the radial head (HP:0003995)1.88447387
78Abnormality of T cells (HP:0002843)1.88400687
79Aortic valve stenosis (HP:0001650)1.88084982
80Recurrent viral infections (HP:0004429)1.88037317
81Interstitial pulmonary disease (HP:0006530)1.87767685
82Porencephaly (HP:0002132)1.87400799
83Hypoplasia of the iris (HP:0007676)1.87306701
84Eczematoid dermatitis (HP:0000976)1.86071991
85Flat capital femoral epiphysis (HP:0003370)1.85876478
86Abnormality of the vasculature of the conjunctiva (HP:0008054)1.84455099
87Neurofibrillary tangles (HP:0002185)1.83872283
88Increased IgM level (HP:0003496)1.83772659
89Abnormality of skull ossification (HP:0002703)1.83707349
90Metaphyseal dysplasia (HP:0100255)1.82865881
91Wormian bones (HP:0002645)1.82277188
92Segmental peripheral demyelination/remyelination (HP:0003481)1.82238347
93Conjunctival telangiectasia (HP:0000524)1.82046330
94Myocardial infarction (HP:0001658)1.81970802
95Mitral regurgitation (HP:0001653)1.81588142
96Joint laxity (HP:0001388)1.81184846
97Hemoptysis (HP:0002105)1.80536093
98Autoimmune thrombocytopenia (HP:0001973)1.79745579
99Mitral stenosis (HP:0001718)1.78109973
100Abnormal delayed hypersensitivity skin test (HP:0002963)1.77790701
101Flared iliac wings (HP:0002869)1.76563042
102Recurrent gram-negative bacterial infections (HP:0005420)1.76103792
103Limited hip movement (HP:0008800)1.76026860
104Gastrointestinal infarctions (HP:0005244)1.75379540
105Dry hair (HP:0011359)1.75157512
106Urinary glycosaminoglycan excretion (HP:0003541)1.75013493
107Mucopolysacchariduria (HP:0008155)1.75013493
108Increased CSF protein (HP:0002922)1.74142838
109Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.72992361
110Aortic regurgitation (HP:0001659)1.72956140
111Chronic otitis media (HP:0000389)1.72941529
112Spondylolisthesis (HP:0003302)1.72938794
113Abnormal sex determination (HP:0012244)1.72465248
114Sex reversal (HP:0012245)1.72465248
115Cranial hyperostosis (HP:0004437)1.72161021
116Dysostosis multiplex (HP:0000943)1.72014687
117True hermaphroditism (HP:0010459)1.71594096
118White forelock (HP:0002211)1.70964675
119Vasculitis (HP:0002633)1.70209694
120Renal dysplasia (HP:0000110)1.70044826
121Recurrent skin infections (HP:0001581)1.69764480
122Abnormality of the nasal septum (HP:0000419)1.68878744
123Abnormality of liposaccharide metabolism (HP:0010968)1.68786510
124Abnormality of glycosphingolipid metabolism (HP:0004343)1.68786510
125Abnormality of glycolipid metabolism (HP:0010969)1.68786510
126Shallow orbits (HP:0000586)1.68576492
127Arterial thrombosis (HP:0004420)1.67825752
128Abnormality of the columella (HP:0009929)1.67715637
129Persistence of primary teeth (HP:0006335)1.67485957
130Abnormality of the intervertebral disk (HP:0005108)1.67309349
131Atrophic scars (HP:0001075)1.66083458
132Capillary hemangiomas (HP:0005306)1.65893944
133Recurrent bronchitis (HP:0002837)1.64644573
134Pulmonary infiltrates (HP:0002113)1.64512081
135Vitreoretinal degeneration (HP:0000655)1.63816300
136Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.63039949
137Short 4th metacarpal (HP:0010044)1.62937759
138Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.62937759
139Follicular hyperkeratosis (HP:0007502)1.61736405
140Clubbing of toes (HP:0100760)1.61553480
141Coarse hair (HP:0002208)1.61073816
142Broad metatarsal (HP:0001783)1.61030828
143Abnormality of the incisor (HP:0000676)1.60798305
144Premature rupture of membranes (HP:0001788)1.59832754
145Short 5th finger (HP:0009237)1.59783703
146Vascular tortuosity (HP:0004948)1.59679211
147Protrusio acetabuli (HP:0003179)1.59327693
148Abnormality of male internal genitalia (HP:0000022)1.59139475
149Lip pit (HP:0100267)1.59105816
150Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.58858069
151Glucose intolerance (HP:0000833)1.58762222
152Dislocated radial head (HP:0003083)1.58710928
153Wide anterior fontanel (HP:0000260)1.58376391
154Striae distensae (HP:0001065)1.58253604
155Patchy hypopigmentation of hair (HP:0011365)1.58146530
15611 pairs of ribs (HP:0000878)1.57988260
157Abnormality of polysaccharide metabolism (HP:0011012)1.57740331
158Abnormality of glycosaminoglycan metabolism (HP:0004371)1.57740331
159Abnormality of mucopolysaccharide metabolism (HP:0011020)1.57740331
160Increased IgE level (HP:0003212)1.57638710
161Vertebral arch anomaly (HP:0008438)1.57012470
162Pustule (HP:0200039)1.56866656
163Tibial bowing (HP:0002982)1.56639346
164Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.56574733
165Periodontitis (HP:0000704)1.54713146

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.03539767
2MKNK23.71875731
3CASK3.59174966
4MAP3K143.08931338
5NLK2.70486077
6IRAK42.49267636
7PRPF4B2.39369125
8RIPK12.35160791
9CDK122.30632205
10TLK12.29331308
11IRAK32.28427231
12NEK92.24656058
13MKNK12.21636425
14IKBKE2.20563591
15MST42.12709119
16EPHB12.09710531
17PDGFRA2.02974495
18JAK31.99874975
19JAK11.97179250
20TGFBR21.93606027
21MAP4K11.90776531
22IKBKB1.89360618
23FGFR41.85508628
24CHUK1.81434519
25NME21.80039800
26AKT31.77534822
27PDGFRB1.73310905
28CDC42BPA1.68163215
29TAOK21.66896055
30TNIK1.66110769
31ERN11.49780463
32CLK11.47750275
33MAP3K131.43634088
34RIPK41.42066362
35WNK11.41252202
36TBK11.39994204
37MAP3K31.36776224
38STK381.32489624
39NUAK11.31484079
40ERBB31.31478720
41EIF2AK21.30385512
42TYK21.28188025
43IRAK11.27723588
44TEC1.27527121
45ZAK1.27147372
46MUSK1.27083089
47RPS6KA41.26479314
48ZAP701.16538853
49PIM21.15225030
50TRPM71.14241820
51TAOK31.11743798
52BMPR21.10520572
53YES11.10262475
54PRKD21.09606420
55MELK1.07384394
56EPHB21.07068372
57PIM11.05711669
58MAP2K31.02898002
59MARK21.01954935
60IRAK21.01407287
61NEK61.01264097
62EPHA31.01229072
63FGR1.01175086
64STK100.98304630
65SGK20.98080530
66LATS10.95500700
67TYRO30.95209194
68KIT0.94394198
69SIK30.92763391
70MAP3K20.92023149
71CAMKK20.91511276
72LCK0.91383640
73CDK60.90242061
74ICK0.89313425
75BTK0.88136750
76MOS0.86820580
77TIE10.86713142
78CSK0.86270945
79GRK70.82599902
80MAP3K100.82373313
81TGFBR10.81473256
82MAPK150.81043121
83MAP3K70.79940204
84PTK2B0.78794052
85SRPK10.76910876
86MAP3K10.75559688
87CAMK1D0.74707773
88TTN0.74610689
89SIK10.74135889
90MAPK130.74066768
91KSR20.72836761
92LYN0.71818612
93ADRBK20.70952377
94STK240.70405724
95MAPK120.68649722
96TRIB30.68133023
97CSF1R0.67768176
98HCK0.66994695
99RET0.66675187
100SGK2230.66461911
101SGK4940.66461911
102FGFR30.65151705
103ITK0.64163823
104LMTK20.63961551
105RPS6KA60.61626525
106TAOK10.60756653
107HIPK20.60332870
108MAPK70.59370276
109STK40.59329564
110CAMK1G0.56361659
111IGF1R0.56300722
112SYK0.55808711
113RPS6KL10.54388898
114RPS6KC10.54388898
115PIK3CA0.53552207
116MTOR0.52331599
117MYLK0.51232664
118DMPK0.50833891
119SGK30.50207485
120PAK20.48633778
121MAP3K60.47647681
122PLK20.47393670
123FES0.47131171
124VRK10.45075931
125CAMK40.44343841
126STK38L0.43699836
127PTK20.43544175
128JAK20.43431535
129DDR20.41347446
130MAPKAPK20.40627039
131BMPR1B0.40565688
132OBSCN0.40254565
133PRKCQ0.39614606
134ROCK10.38154617
135PIK3CG0.37024508
136CDK80.36922966
137MARK30.35402184
138PRKG20.34136343
139MAPK40.33656650
140MAPK30.33645008
141ABL10.32677921
142DYRK1A0.29279618
143BRD40.29149189
144PRKCD0.29040122
145BLK0.28195506
146PLK40.25889047
147INSR0.24785762

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.12310839
2Graft-versus-host disease_Homo sapiens_hsa053322.50514955
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.49215323
4Measles_Homo sapiens_hsa051622.27921940
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.24763736
6Allograft rejection_Homo sapiens_hsa053302.18313624
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.16629013
8Leishmaniasis_Homo sapiens_hsa051402.08840610
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.95967250
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.85921870
11Jak-STAT signaling pathway_Homo sapiens_hsa046301.85293405
12Malaria_Homo sapiens_hsa051441.81153334
13Hematopoietic cell lineage_Homo sapiens_hsa046401.74761144
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.70798901
15Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.68791628
16Herpes simplex infection_Homo sapiens_hsa051681.63017143
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.55527830
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.54645823
19Autoimmune thyroid disease_Homo sapiens_hsa053201.53194463
20Osteoclast differentiation_Homo sapiens_hsa043801.51938510
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.51241577
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.45049768
23Dorso-ventral axis formation_Homo sapiens_hsa043201.45020926
24Antigen processing and presentation_Homo sapiens_hsa046121.41741543
25Staphylococcus aureus infection_Homo sapiens_hsa051501.41703773
26T cell receptor signaling pathway_Homo sapiens_hsa046601.37425301
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33388124
28TNF signaling pathway_Homo sapiens_hsa046681.31889345
29B cell receptor signaling pathway_Homo sapiens_hsa046621.29164360
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.28288138
31Renal cell carcinoma_Homo sapiens_hsa052111.27565171
32Hepatitis B_Homo sapiens_hsa051611.27534601
33Toxoplasmosis_Homo sapiens_hsa051451.27158593
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26286046
35ECM-receptor interaction_Homo sapiens_hsa045121.22446104
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22145279
37Influenza A_Homo sapiens_hsa051641.19834856
38Endometrial cancer_Homo sapiens_hsa052131.18249659
39Viral myocarditis_Homo sapiens_hsa054161.16329564
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16193166
41Non-small cell lung cancer_Homo sapiens_hsa052231.16116751
42HTLV-I infection_Homo sapiens_hsa051661.14336871
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12008544
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10593210
45Prostate cancer_Homo sapiens_hsa052151.07105669
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06183589
47Basal cell carcinoma_Homo sapiens_hsa052171.06115524
48Focal adhesion_Homo sapiens_hsa045101.02274968
49Small cell lung cancer_Homo sapiens_hsa052221.01604882
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.00054476
51Apoptosis_Homo sapiens_hsa042100.99768495
52* Notch signaling pathway_Homo sapiens_hsa043300.98508984
53Pertussis_Homo sapiens_hsa051330.97761317
54Fanconi anemia pathway_Homo sapiens_hsa034600.97633671
55Chemokine signaling pathway_Homo sapiens_hsa040620.95879907
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.95225353
57MicroRNAs in cancer_Homo sapiens_hsa052060.93800549
58Other glycan degradation_Homo sapiens_hsa005110.93702545
59VEGF signaling pathway_Homo sapiens_hsa043700.92719255
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91583760
61Chronic myeloid leukemia_Homo sapiens_hsa052200.91076813
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90610765
63Tuberculosis_Homo sapiens_hsa051520.88985642
64Adherens junction_Homo sapiens_hsa045200.86905224
65ErbB signaling pathway_Homo sapiens_hsa040120.85865646
66Rheumatoid arthritis_Homo sapiens_hsa053230.85743406
67Platelet activation_Homo sapiens_hsa046110.85722069
68Homologous recombination_Homo sapiens_hsa034400.85166010
69Prolactin signaling pathway_Homo sapiens_hsa049170.85065846
70Choline metabolism in cancer_Homo sapiens_hsa052310.84994048
71Acute myeloid leukemia_Homo sapiens_hsa052210.84068850
72Thyroid cancer_Homo sapiens_hsa052160.84043562
73PI3K-Akt signaling pathway_Homo sapiens_hsa041510.83643584
74Glioma_Homo sapiens_hsa052140.83125888
75mTOR signaling pathway_Homo sapiens_hsa041500.81702837
76p53 signaling pathway_Homo sapiens_hsa041150.79006760
77Shigellosis_Homo sapiens_hsa051310.77993004
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76096685
79Complement and coagulation cascades_Homo sapiens_hsa046100.75989660
80Hepatitis C_Homo sapiens_hsa051600.75926327
81Wnt signaling pathway_Homo sapiens_hsa043100.75871922
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.75712941
83GnRH signaling pathway_Homo sapiens_hsa049120.75324724
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74747205
85African trypanosomiasis_Homo sapiens_hsa051430.74630852
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.74170928
87Lysosome_Homo sapiens_hsa041420.72546763
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72411017
89Phagosome_Homo sapiens_hsa041450.72152080
90Pathways in cancer_Homo sapiens_hsa052000.71918269
91MAPK signaling pathway_Homo sapiens_hsa040100.71510251
92Type I diabetes mellitus_Homo sapiens_hsa049400.71378101
93Legionellosis_Homo sapiens_hsa051340.70899286
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70555940
95Asthma_Homo sapiens_hsa053100.70034788
96Base excision repair_Homo sapiens_hsa034100.69372804
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69116876
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68778129
99Proteoglycans in cancer_Homo sapiens_hsa052050.66761895
100Salmonella infection_Homo sapiens_hsa051320.64804955
101TGF-beta signaling pathway_Homo sapiens_hsa043500.64780998
102Estrogen signaling pathway_Homo sapiens_hsa049150.64299745
103Insulin resistance_Homo sapiens_hsa049310.64090318
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63504516
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63362196
106Endocytosis_Homo sapiens_hsa041440.62584487
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61673966
108HIF-1 signaling pathway_Homo sapiens_hsa040660.61641593
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61624461
110Prion diseases_Homo sapiens_hsa050200.61366362
111Ras signaling pathway_Homo sapiens_hsa040140.61214665
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.60198694
113Inositol phosphate metabolism_Homo sapiens_hsa005620.59844853
114Arachidonic acid metabolism_Homo sapiens_hsa005900.59207428
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.58550095
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57786143
117Ribosome_Homo sapiens_hsa030100.57501405
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53362294
119Pancreatic cancer_Homo sapiens_hsa052120.53240363
120Hippo signaling pathway_Homo sapiens_hsa043900.52313530
121Melanogenesis_Homo sapiens_hsa049160.51193772
122Epstein-Barr virus infection_Homo sapiens_hsa051690.51107869
123Rap1 signaling pathway_Homo sapiens_hsa040150.50968716
124Amoebiasis_Homo sapiens_hsa051460.50960354
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50571444
126DNA replication_Homo sapiens_hsa030300.50154512
127FoxO signaling pathway_Homo sapiens_hsa040680.49888371
128Protein digestion and absorption_Homo sapiens_hsa049740.49070484
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48321511
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47072818
131Dilated cardiomyopathy_Homo sapiens_hsa054140.46749663
132Colorectal cancer_Homo sapiens_hsa052100.46500295
133Melanoma_Homo sapiens_hsa052180.45118942
134Sphingolipid metabolism_Homo sapiens_hsa006000.45013230

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