MAMLD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mastermind-like domain containing protein. This protein may function as a transcriptional co-activator. Mutations in this gene are the cause of X-linked hypospadias type 2. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.32287292
2regulation of vitamin D biosynthetic process (GO:0060556)5.00488963
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.99064064
4vocalization behavior (GO:0071625)4.70939308
5synaptic vesicle exocytosis (GO:0016079)4.68827476
6glycine transport (GO:0015816)4.64432820
7virion attachment to host cell (GO:0019062)4.57827755
8adhesion of symbiont to host cell (GO:0044650)4.57827755
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.55216807
10locomotory exploration behavior (GO:0035641)4.55141990
11positive regulation of male gonad development (GO:2000020)4.55102191
12regulation of synaptic vesicle exocytosis (GO:2000300)4.46115031
13synaptic vesicle maturation (GO:0016188)4.42680764
14protein localization to synapse (GO:0035418)4.33161344
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.26349206
16regulation of chronic inflammatory response (GO:0002676)4.22353876
17diaphragm development (GO:0060539)4.14234622
18positive regulation of chemokine biosynthetic process (GO:0045080)4.12957573
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.11913101
20glutamate secretion (GO:0014047)4.09681105
21cell adhesion mediated by integrin (GO:0033627)3.99601537
22metanephric mesenchyme development (GO:0072075)3.97707104
23adhesion of symbiont to host (GO:0044406)3.95697194
24neuron cell-cell adhesion (GO:0007158)3.90794665
25regulation of synaptic vesicle transport (GO:1902803)3.88434265
26skeletal muscle organ development (GO:0060538)3.84446678
27regulation of glutamate receptor signaling pathway (GO:1900449)3.83233582
28kidney mesenchyme development (GO:0072074)3.82691323
29ionotropic glutamate receptor signaling pathway (GO:0035235)3.79103573
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.78317000
31negative regulation of nitric oxide biosynthetic process (GO:0045019)3.75738095
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.74380167
33neurotransmitter-gated ion channel clustering (GO:0072578)3.73574172
34regulation of podosome assembly (GO:0071801)3.73038183
35positive regulation of heat generation (GO:0031652)3.70677518
36neurotransmitter secretion (GO:0007269)3.69877188
37substrate-dependent cell migration (GO:0006929)3.65867362
38innervation (GO:0060384)3.65324341
39cellular potassium ion homeostasis (GO:0030007)3.64470846
40positive regulation of vesicle fusion (GO:0031340)3.63903532
41regulation of fever generation (GO:0031620)3.63372330
42synaptic transmission, glutamatergic (GO:0035249)3.58191661
43regulation of vitamin metabolic process (GO:0030656)3.58147232
44glutamate receptor signaling pathway (GO:0007215)3.58028645
45positive regulation of synapse maturation (GO:0090129)3.55616916
46regulation of male gonad development (GO:2000018)3.53698968
47regulation of vesicle fusion (GO:0031338)3.52841269
48exploration behavior (GO:0035640)3.52115833
49proline transport (GO:0015824)3.41494809
50regulation of chemokine biosynthetic process (GO:0045073)3.41264716
51regulation of membrane protein ectodomain proteolysis (GO:0051043)3.38398037
52neuron-neuron synaptic transmission (GO:0007270)3.37654834
53long-term synaptic potentiation (GO:0060291)3.36288174
54regulation of excitatory postsynaptic membrane potential (GO:0060079)3.34961215
55skin morphogenesis (GO:0043589)3.33220973
56negative regulation of synaptic transmission, GABAergic (GO:0032229)3.30921779
57regulation of neuronal synaptic plasticity (GO:0048168)3.30748810
58positive regulation of synaptic transmission, GABAergic (GO:0032230)3.30138258
59glomerular basement membrane development (GO:0032836)3.28716921
60G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.27156694
61regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.24697933
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.24457389
63regulation of long-term neuronal synaptic plasticity (GO:0048169)3.23552956
64regulation of postsynaptic membrane potential (GO:0060078)3.23125221
65regulation of cytokine secretion involved in immune response (GO:0002739)3.22628720
66regulation of synapse structural plasticity (GO:0051823)3.21411610
67negative regulation of amino acid transport (GO:0051956)3.19757549
68neuronal action potential propagation (GO:0019227)3.19272295
69positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.18742357
70cerebellar Purkinje cell differentiation (GO:0021702)3.16712939
71gamma-aminobutyric acid signaling pathway (GO:0007214)3.15892064
72negative regulation of metanephros development (GO:0072217)3.15543712
73regulation of gonadotropin secretion (GO:0032276)3.15537804
74type B pancreatic cell proliferation (GO:0044342)3.13464714
75regulation of immunoglobulin secretion (GO:0051023)3.13035728
76regulation of synaptic transmission, glutamatergic (GO:0051966)3.12779903
77activation of protein kinase A activity (GO:0034199)3.11824173
78positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.11347761
79axon extension involved in axon guidance (GO:0048846)3.10042683
80neuron projection extension involved in neuron projection guidance (GO:1902284)3.10042683
81regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.07321924
82layer formation in cerebral cortex (GO:0021819)3.06651988
83mechanosensory behavior (GO:0007638)3.06563502
84protein heterotrimerization (GO:0070208)3.06502439
85regulation of neurotransmitter secretion (GO:0046928)3.04557584
86synaptic vesicle endocytosis (GO:0048488)3.03429153
87long-term memory (GO:0007616)3.02609451
88regulation of calcium ion-dependent exocytosis (GO:0017158)3.02006974
89cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.99908133
90cerebellar granule cell differentiation (GO:0021707)2.99845771
91membrane depolarization during action potential (GO:0086010)2.99502664
92regulation of nitric oxide biosynthetic process (GO:0045428)2.98958239
93regulation of cell proliferation involved in kidney development (GO:1901722)2.98243884
94neurotransmitter transport (GO:0006836)2.98168678
95positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.97616411
96regulation of heat generation (GO:0031650)2.97270830
97glial cell migration (GO:0008347)2.95382344
98regulation of integrin-mediated signaling pathway (GO:2001044)2.95079191
99sodium ion export (GO:0071436)2.94260050
100dendritic spine morphogenesis (GO:0060997)2.93843966
101muscle cell cellular homeostasis (GO:0046716)2.93150417
102detection of calcium ion (GO:0005513)2.92935073
103regulation of synaptic plasticity (GO:0048167)2.91648582
104positive regulation of neurotransmitter secretion (GO:0001956)2.91306768
105positive regulation of membrane potential (GO:0045838)2.91256048
106positive regulation of synapse assembly (GO:0051965)2.89443820
107cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.89378875
108extracellular matrix assembly (GO:0085029)2.86494059
109membrane hyperpolarization (GO:0060081)2.84658371
110cell communication by electrical coupling (GO:0010644)2.84332573
111postsynaptic membrane organization (GO:0001941)2.83427790
112positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.83340055
113extracellular fibril organization (GO:0043206)2.83012185
114negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.82994585
115response to histamine (GO:0034776)2.82533645
116collagen fibril organization (GO:0030199)2.81085472
117negative regulation of axon extension involved in axon guidance (GO:0048843)2.80745188
118membrane depolarization (GO:0051899)2.80341737
119negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80266628
120auditory behavior (GO:0031223)2.79163352
121positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.78832426
122endocardial cushion development (GO:0003197)2.78798378
123gamma-aminobutyric acid transport (GO:0015812)2.77720714
124regulation of neurotransmitter transport (GO:0051588)2.75786611
125regulation of synapse maturation (GO:0090128)2.74286145
126neuron recognition (GO:0008038)2.73807956
127positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.73762660
128long term synaptic depression (GO:0060292)2.73756420
129response to gonadotropin (GO:0034698)2.72971542
130mating behavior (GO:0007617)2.72867809
131regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.72829726
132potassium ion homeostasis (GO:0055075)2.72631545
133response to auditory stimulus (GO:0010996)2.71610675
134positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.71315217
135positive regulation of synaptic transmission (GO:0050806)2.71314574
136chondroitin sulfate catabolic process (GO:0030207)2.70405300
137positive regulation of astrocyte differentiation (GO:0048711)2.69985779
138regulation of synaptic transmission, GABAergic (GO:0032228)2.68641802
139presynaptic membrane assembly (GO:0097105)2.67152759
140fibril organization (GO:0097435)2.66203690
141suckling behavior (GO:0001967)2.65733260
142ganglion development (GO:0061548)2.65628247
143behavioral defense response (GO:0002209)2.65464478
144behavioral fear response (GO:0001662)2.65464478
145lipopolysaccharide biosynthetic process (GO:0009103)2.65406923
146fibroblast migration (GO:0010761)2.64298761
147regulation of axon extension involved in axon guidance (GO:0048841)2.63999417
148chemosensory behavior (GO:0007635)2.63957078
149positive regulation of nitric oxide biosynthetic process (GO:0045429)2.63938414
150axonal fasciculation (GO:0007413)2.63547886
151regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.62816655
152response to pheromone (GO:0019236)2.62631801
153signal release (GO:0023061)2.62173311
154sequestering of extracellular ligand from receptor (GO:0035581)2.62010496
155heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.62004204
156neuromuscular process controlling posture (GO:0050884)2.61875322
157regulation of beta-amyloid formation (GO:1902003)2.61850080
158regulation of amyloid precursor protein catabolic process (GO:1902991)2.61444419
159synaptic transmission (GO:0007268)2.61040902
160synapse assembly (GO:0007416)2.60712249
161regulation of neurotransmitter levels (GO:0001505)2.60328624
162cellular response to gonadotropin stimulus (GO:0071371)2.59552055
163decidualization (GO:0046697)2.58386792
164negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.55506408
165regulation of mononuclear cell migration (GO:0071675)2.55006329
166endocytic recycling (GO:0032456)2.49891138
167dermatan sulfate biosynthetic process (GO:0030208)2.48125519
168eosinophil chemotaxis (GO:0048245)2.47155334
169chondroitin sulfate biosynthetic process (GO:0030206)2.46480887
170axon extension (GO:0048675)2.45776603
171endodermal cell differentiation (GO:0035987)2.44978461
172negative regulation of monooxygenase activity (GO:0032769)2.44813786
173dermatan sulfate metabolic process (GO:0030205)2.43670264
174positive regulation of metanephros development (GO:0072216)2.43518310
175regulation of heterotypic cell-cell adhesion (GO:0034114)2.43159984
176regulation of chemokine-mediated signaling pathway (GO:0070099)2.41444988
177endoderm formation (GO:0001706)2.41134240
178negative regulation of axon guidance (GO:1902668)2.39754653
179regulation of axon guidance (GO:1902667)2.39446221
180regulation of metanephros development (GO:0072215)2.38735505
181keratan sulfate catabolic process (GO:0042340)2.38126870
182cellular response to interferon-alpha (GO:0035457)2.36617000
183branching involved in labyrinthine layer morphogenesis (GO:0060670)2.35878889
184chondrocyte proliferation (GO:0035988)2.35628148
185cellular response to nicotine (GO:0071316)2.35540449
186positive regulation of smooth muscle cell migration (GO:0014911)2.35002640
187negative chemotaxis (GO:0050919)2.33729134
188regulation of vascular endothelial growth factor production (GO:0010574)2.32565616
189response to gravity (GO:0009629)2.31010944
190regulation of glomerulus development (GO:0090192)2.30996820
191regulation of T-helper 1 cell differentiation (GO:0045625)2.30648887
192regulation of glutamate secretion (GO:0014048)2.27319150
193protein localization to endosome (GO:0036010)2.26470006
194retina vasculature morphogenesis in camera-type eye (GO:0061299)2.25924485
195negative regulation of smooth muscle cell migration (GO:0014912)2.25544541
196positive regulation vascular endothelial growth factor production (GO:0010575)2.24522559
197negative regulation of macrophage differentiation (GO:0045650)2.24500221
198stress fiber assembly (GO:0043149)2.23920907
199negative regulation of nitric-oxide synthase activity (GO:0051001)2.22761387

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.59705053
2GBX2_23144817_ChIP-Seq_PC3_Human3.53452559
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.42110583
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03331763
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99757292
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69032414
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.62367749
8IKZF1_21737484_ChIP-ChIP_HCT116_Human2.55572219
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52156869
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51050498
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50108289
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47692142
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47692142
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45270271
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.42915348
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38928559
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36099240
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.36010973
19WT1_19549856_ChIP-ChIP_CCG9911_Human2.31853899
20REST_21632747_ChIP-Seq_MESCs_Mouse2.31707918
21CJUN_26792858_Chip-Seq_BT549_Human2.29387408
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28243775
23DROSHA_22980978_ChIP-Seq_HELA_Human2.23266916
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.19198675
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.18395997
26* EZH2_27294783_Chip-Seq_ESCs_Mouse2.15537527
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12603224
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.07615678
29CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.05759139
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.98713703
31BRD4_25478319_ChIP-Seq_HGPS_Human1.96505257
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.94955909
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.91644137
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91331296
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91123621
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83505897
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.81340046
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.81340046
39SMAD4_21799915_ChIP-Seq_A2780_Human1.80741946
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.80341652
41AR_21572438_ChIP-Seq_LNCaP_Human1.77278440
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.76998972
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.73541641
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73350826
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.67874893
46JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67677777
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65771398
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64866331
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.63345984
50JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59329668
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.58989222
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58362675
53ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.55480151
54RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.54890646
55CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.49472786
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49198046
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48264623
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.48039750
59CLOCK_20551151_ChIP-Seq_293T_Human1.46417824
60P300_19829295_ChIP-Seq_ESCs_Human1.45768693
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45719248
62TAF15_26573619_Chip-Seq_HEK293_Human1.43519683
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43178277
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42597654
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41006408
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.38975884
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.38629035
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37666173
69EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34293498
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.33792185
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33577478
72STAT3_23295773_ChIP-Seq_U87_Human1.33219980
73IGF1R_20145208_ChIP-Seq_DFB_Human1.32653404
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32566966
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31345790
76ZNF274_21170338_ChIP-Seq_K562_Hela1.30718166
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.27398694
78AR_25329375_ChIP-Seq_VCAP_Human1.27019238
79AR_19668381_ChIP-Seq_PC3_Human1.26800760
80SA1_22415368_ChIP-Seq_MEFs_Mouse1.26564400
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26538657
82* GATA2_21666600_ChIP-Seq_HMVEC_Human1.26304201
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26302821
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25678965
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24853541
86TP53_20018659_ChIP-ChIP_R1E_Mouse1.24157307
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22721211
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22543616
89ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20449681
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19891033
91SMC1_22415368_ChIP-Seq_MEFs_Mouse1.19797641
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19117839
93SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18883852
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.18842120
95STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18610291
96TCF4_23295773_ChIP-Seq_U87_Human1.17354559
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15985084
98SOX2_20726797_ChIP-Seq_SW620_Human1.14202398
99NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13879379
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13717359
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13417027
102ERG_21242973_ChIP-ChIP_JURKAT_Human1.12848293
103VDR_22108803_ChIP-Seq_LS180_Human1.12599109
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11646446
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.11361625
106FUS_26573619_Chip-Seq_HEK293_Human1.10779960
107SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10694892
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10694892
109RNF2_27304074_Chip-Seq_NSC_Mouse1.10411836
110TRIM28_21343339_ChIP-Seq_HEK293_Human1.10269981
111YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09462749
112RUNX2_22187159_ChIP-Seq_PCA_Human1.07991912
113NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07165782
114TP53_16413492_ChIP-PET_HCT116_Human1.06712792
115AHR_22903824_ChIP-Seq_MCF-7_Human1.06518639
116EP300_21415370_ChIP-Seq_HL-1_Mouse1.05392732
117NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05191674
118P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04857975
119BCAT_22108803_ChIP-Seq_LS180_Human1.03989346
120SMAD4_21741376_ChIP-Seq_HESCs_Human1.03928427
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01819808
122P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99709117
123TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99548847
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.99358334
125* RING1B_27294783_Chip-Seq_NPCs_Mouse0.97680277
126MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97388600
127UBF1/2_26484160_Chip-Seq_HMECs_Human0.96615299
128SMAD3_21741376_ChIP-Seq_HESCs_Human0.96502207
129DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95619423
130RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95192223
131TP53_18474530_ChIP-ChIP_U2OS_Human0.94467942
132* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94390462
133TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93825761
134ER_23166858_ChIP-Seq_MCF-7_Human0.93812377
135NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92955934
136KDM2B_26808549_Chip-Seq_REH_Human0.91055862
137VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90740297
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90475736
139* TP53_23651856_ChIP-Seq_MEFs_Mouse0.89237849
140NANOG_18555785_Chip-Seq_ESCs_Mouse0.89159601
141ELK3_25401928_ChIP-Seq_HUVEC_Human0.88679641
142MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88044360
143TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87963184
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87755954
145SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87567709
146SMC3_22415368_ChIP-Seq_MEFs_Mouse0.86850840
147VDR_24787735_ChIP-Seq_THP-1_Human0.86637247
148SMAD4_21741376_ChIP-Seq_EPCs_Human0.86548215
149NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86201069
150EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85445045
151* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85070840

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.59407205
2MP0004859_abnormal_synaptic_plasticity5.05619179
3MP0005257_abnormal_intraocular_pressure4.11708918
4MP0003635_abnormal_synaptic_transmissio3.44457583
5MP0004270_analgesia3.12808020
6MP0003880_abnormal_central_pattern3.09034330
7MP0003279_aneurysm3.05192459
8MP0003303_peritoneal_inflammation2.93178852
9MP0001542_abnormal_bone_strength2.92026753
10MP0009745_abnormal_behavioral_response2.87532378
11MP0009046_muscle_twitch2.85540175
12MP0003705_abnormal_hypodermis_morpholog2.82039664
13MP0002063_abnormal_learning/memory/cond2.78947594
14MP0002064_seizures2.76510090
15MP0000013_abnormal_adipose_tissue2.70397398
16MP0009384_cardiac_valve_regurgitation2.68446131
17MP0005058_abnormal_lysosome_morphology2.65860239
18MP0002332_abnormal_exercise_endurance2.63677991
19MP0001968_abnormal_touch/_nociception2.61612843
20MP0002572_abnormal_emotion/affect_behav2.50677087
21MP0006054_spinal_hemorrhage2.49712722
22MP0001958_emphysema2.48979360
23MP0009780_abnormal_chondrocyte_physiolo2.44399443
24MP0004272_abnormal_basement_membrane2.36586773
25MP0002734_abnormal_mechanical_nocicepti2.36281247
26MP0002272_abnormal_nervous_system2.31902700
27MP0005645_abnormal_hypothalamus_physiol2.29553810
28MP0005551_abnormal_eye_electrophysiolog2.21285204
29MP0002735_abnormal_chemical_nociception2.20157226
30MP0003091_abnormal_cell_migration2.11585087
31MP0002909_abnormal_adrenal_gland2.09850994
32MP0002736_abnormal_nociception_after2.09027839
33MP0000749_muscle_degeneration2.05823020
34MP0001501_abnormal_sleep_pattern2.01398026
35MP0002295_abnormal_pulmonary_circulatio1.99914946
36MP0003787_abnormal_imprinting1.94096358
37MP0003122_maternal_imprinting1.91895467
38MP0003183_abnormal_peptide_metabolism1.91112431
39MP0006072_abnormal_retinal_apoptosis1.88646101
40MP0005503_abnormal_tendon_morphology1.88355543
41MP0002184_abnormal_innervation1.87378463
42MP0004858_abnormal_nervous_system1.86156735
43MP0001486_abnormal_startle_reflex1.84859902
44MP0002837_dystrophic_cardiac_calcinosis1.84454162
45MP0002067_abnormal_sensory_capabilities1.83789024
46MP0003950_abnormal_plasma_membrane1.83335940
47MP0002822_catalepsy1.82256259
48MP0005275_abnormal_skin_tensile1.79998269
49MP0005595_abnormal_vascular_smooth1.79854290
50MP0006082_CNS_inflammation1.78406493
51MP0005623_abnormal_meninges_morphology1.77726408
52MP0001502_abnormal_circadian_rhythm1.77228856
53MP0002733_abnormal_thermal_nociception1.77197952
54MP0009840_abnormal_foam_cell1.77056295
55MP0005423_abnormal_somatic_nervous1.75369343
56MP0005646_abnormal_pituitary_gland1.74408333
57MP0005508_abnormal_skeleton_morphology1.71223166
58MP0003879_abnormal_hair_cell1.70827341
59MP0008569_lethality_at_weaning1.69182465
60MP0001440_abnormal_grooming_behavior1.66996082
61MP0010386_abnormal_urinary_bladder1.65647361
62MP0002557_abnormal_social/conspecific_i1.63894916
63MP0001970_abnormal_pain_threshold1.62810293
64MP0000767_abnormal_smooth_muscle1.59641587
65MP0001984_abnormal_olfaction1.59012481
66MP0003075_altered_response_to1.58687435
67MP0003566_abnormal_cell_adhesion1.58049716
68MP0000343_altered_response_to1.57037967
69MP0002896_abnormal_bone_mineralization1.47976127
70MP0005253_abnormal_eye_physiology1.47524406
71MP0002638_abnormal_pupillary_reflex1.47250420
72MP0000778_abnormal_nervous_system1.46213188
73MP0003329_amyloid_beta_deposits1.45707169
74MP0010368_abnormal_lymphatic_system1.44907717
75MP0005023_abnormal_wound_healing1.42887196
76MP0005386_behavior/neurological_phenoty1.42206838
77MP0004924_abnormal_behavior1.42206838
78MP0004811_abnormal_neuron_physiology1.41804899
79MP0004885_abnormal_endolymph1.39987009
80MP0000003_abnormal_adipose_tissue1.38690826
81MP0002090_abnormal_vision1.37667120
82MP0006276_abnormal_autonomic_nervous1.37211908
83MP0001243_abnormal_dermal_layer1.37169162
84MP0004233_abnormal_muscle_weight1.33177458
85MP0002882_abnormal_neuron_morphology1.31830638
86MP0002877_abnormal_melanocyte_morpholog1.29880316
87MP0004215_abnormal_myocardial_fiber1.25529473
88MP0003123_paternal_imprinting1.23437565
89MP0003195_calcinosis1.21840380
90MP0000631_abnormal_neuroendocrine_gland1.20065158
91MP0003633_abnormal_nervous_system1.18257280
92MP0004145_abnormal_muscle_electrophysio1.17458025
93MP0000955_abnormal_spinal_cord1.17137711
94MP0010030_abnormal_orbit_morphology1.16600716
95MP0000751_myopathy1.16481695
96MP0004043_abnormal_pH_regulation1.13093025
97MP0005390_skeleton_phenotype1.12629932
98MP0002876_abnormal_thyroid_physiology1.12244097
99MP0003448_altered_tumor_morphology1.11799103
100MP0005197_abnormal_uvea_morphology1.11776631
101MP0002066_abnormal_motor_capabilities/c1.11672415
102MP0005165_increased_susceptibility_to1.10994374
103MP0008961_abnormal_basal_metabolism1.08658903
104MP0001529_abnormal_vocalization1.07758117
105MP0003300_gastrointestinal_ulcer1.04178139
106MP0002229_neurodegeneration1.01242216
107MP0005164_abnormal_response_to1.01031216
108MP0000538_abnormal_urinary_bladder0.98320905
109MP0002653_abnormal_ependyma_morphology0.96529421
110MP0003631_nervous_system_phenotype0.94790761
111MP0000604_amyloidosis0.94726461
112MP0000920_abnormal_myelination0.94669684
113MP0002069_abnormal_eating/drinking_beha0.91695538
114MP0004085_abnormal_heartbeat0.91581450
115MP0000759_abnormal_skeletal_muscle0.91113523
116MP0000733_abnormal_muscle_development0.90779624
117MP0001533_abnormal_skeleton_physiology0.90314347
118MP0002751_abnormal_autonomic_nervous0.88594836
119MP0000569_abnormal_digit_pigmentation0.87960517
120MP0003942_abnormal_urinary_system0.87689887
121MP0005167_abnormal_blood-brain_barrier0.87450149
122MP0002152_abnormal_brain_morphology0.86795344
123MP0001727_abnormal_embryo_implantation0.85376797
124MP0000750_abnormal_muscle_regeneration0.85186256
125MP0008004_abnormal_stomach_pH0.84937957
126MP0003045_fibrosis0.84349707
127MP0001188_hyperpigmentation0.83955570
128MP0010352_gastrointestinal_tract_polyps0.83580793
129MP0001853_heart_inflammation0.83239582
130MP0004142_abnormal_muscle_tone0.82943041
131MP0003634_abnormal_glial_cell0.82644288
132MP0005084_abnormal_gallbladder_morpholo0.82052061
133MP0001299_abnormal_eye_distance/0.81747820
134MP0002148_abnormal_hypersensitivity_rea0.81485928
135MP0004742_abnormal_vestibular_system0.80129609
136MP0004510_myositis0.79971432
137MP0003283_abnormal_digestive_organ0.79439185
138MP0000163_abnormal_cartilage_morphology0.79031365
139MP0001944_abnormal_pancreas_morphology0.78993922
140MP0000639_abnormal_adrenal_gland0.78718801
141MP0009250_abnormal_appendicular_skeleto0.78390501
142MP0002752_abnormal_somatic_nervous0.78253503
143MP0002282_abnormal_trachea_morphology0.77150625
144MP0003121_genomic_imprinting0.77086079
145MP0002168_other_aberrant_phenotype0.76249898
146MP0003453_abnormal_keratinocyte_physiol0.75644905
147MP0002139_abnormal_hepatobiliary_system0.75357312
148MP0009764_decreased_sensitivity_to0.75347150
149MP0002115_abnormal_skeleton_extremities0.75322951
150MP0003137_abnormal_impulse_conducting0.74063153
151MP0005535_abnormal_body_temperature0.74050321
152MP0002060_abnormal_skin_morphology0.73167367
153MP0003828_pulmonary_edema0.73100534
154MP0001348_abnormal_lacrimal_gland0.73005703
155MP0005171_absent_coat_pigmentation0.72507965
156MP0005195_abnormal_posterior_eye0.71696881
157MP0005187_abnormal_penis_morphology0.71579767
158MP0001963_abnormal_hearing_physiology0.71307104
159MP0002254_reproductive_system_inflammat0.70438697
160MP0003632_abnormal_nervous_system0.69907117
161MP0003221_abnormal_cardiomyocyte_apopto0.69655201
162MP0002972_abnormal_cardiac_muscle0.69129479
163MP0005379_endocrine/exocrine_gland_phen0.68968791
164MP0003172_abnormal_lysosome_physiology0.68599700
165MP0002998_abnormal_bone_remodeling0.68262494
166MP0003186_abnormal_redox_activity0.66942772
167MP0000534_abnormal_ureter_morphology0.66928076
168MP0004036_abnormal_muscle_relaxation0.66068075
169MP0005166_decreased_susceptibility_to0.63071854
170MP0002078_abnormal_glucose_homeostasis0.63043576
171MP0003385_abnormal_body_wall0.62732526
172MP0005367_renal/urinary_system_phenotyp0.60780712
173MP0000516_abnormal_urinary_system0.60780712
174MP0002693_abnormal_pancreas_physiology0.59902933
175MP0001765_abnormal_ion_homeostasis0.59014898
176MP0004484_altered_response_of0.58393640
177MP0005620_abnormal_muscle_contractility0.57166437

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.80345877
2Focal motor seizures (HP:0011153)5.40027552
3Protrusio acetabuli (HP:0003179)5.01456302
4Epileptic encephalopathy (HP:0200134)4.66999022
5Progressive cerebellar ataxia (HP:0002073)4.43762163
6Focal seizures (HP:0007359)4.21204189
7Myokymia (HP:0002411)4.16695395
8Atonic seizures (HP:0010819)4.06850312
9Febrile seizures (HP:0002373)4.02261119
10Visual hallucinations (HP:0002367)3.94492536
11Abnormality of liposaccharide metabolism (HP:0010968)3.89146099
12Abnormality of glycosphingolipid metabolism (HP:0004343)3.89146099
13Abnormality of glycolipid metabolism (HP:0010969)3.89146099
14Mesangial abnormality (HP:0001966)3.76685826
15Action tremor (HP:0002345)3.71566834
16Absence seizures (HP:0002121)3.66556395
17Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.63196941
18Hemiparesis (HP:0001269)3.42640629
19Vertebral compression fractures (HP:0002953)3.30317569
20Nuclear cataract (HP:0100018)3.29181273
21Dialeptic seizures (HP:0011146)3.25440034
22Ankle contracture (HP:0006466)3.23868963
23Retinal atrophy (HP:0001105)3.15055515
24Dysdiadochokinesis (HP:0002075)3.14250891
25Congenital stationary night blindness (HP:0007642)3.13221143
26Central scotoma (HP:0000603)3.12978778
27Hyperventilation (HP:0002883)3.11812084
28Generalized tonic-clonic seizures (HP:0002069)3.10435859
29Genetic anticipation (HP:0003743)3.06159851
30Agitation (HP:0000713)3.03639338
31Gaze-evoked nystagmus (HP:0000640)2.98456482
32Abnormality of calcium-phosphate metabolism (HP:0100530)2.98443892
33Aortic dissection (HP:0002647)2.96139073
34Pheochromocytoma (HP:0002666)2.94974918
35Abnormality of polysaccharide metabolism (HP:0011012)2.89651472
36Abnormality of glycosaminoglycan metabolism (HP:0004371)2.89651472
37Abnormality of mucopolysaccharide metabolism (HP:0011020)2.89651472
38Bladder diverticulum (HP:0000015)2.88042112
39Spinal rigidity (HP:0003306)2.87934898
40Neonatal short-limb short stature (HP:0008921)2.86162711
41Epileptiform EEG discharges (HP:0011182)2.82570902
42Depression (HP:0000716)2.81843933
43Abnormality of macular pigmentation (HP:0008002)2.80835398
44Cervical subluxation (HP:0003308)2.79825090
45Axonal loss (HP:0003447)2.79536426
46Dysostosis multiplex (HP:0000943)2.77674786
47Broad-based gait (HP:0002136)2.76784759
48Abnormality of dentin (HP:0010299)2.75963926
49Follicular hyperkeratosis (HP:0007502)2.74341971
50Mucopolysacchariduria (HP:0008155)2.71347960
51Urinary glycosaminoglycan excretion (HP:0003541)2.71347960
52Blue irides (HP:0000635)2.70203984
53Truncal ataxia (HP:0002078)2.70138256
54EEG with generalized epileptiform discharges (HP:0011198)2.66147672
55Aortic aneurysm (HP:0004942)2.64581469
56Impaired smooth pursuit (HP:0007772)2.64422750
57Upper limb amyotrophy (HP:0009129)2.61581250
58Distal upper limb amyotrophy (HP:0007149)2.61581250
59Atrophic scars (HP:0001075)2.59361714
60Mitral stenosis (HP:0001718)2.57149285
61Neuroendocrine neoplasm (HP:0100634)2.55588320
62Anxiety (HP:0000739)2.54816018
63Hypoventilation (HP:0002791)2.54655191
64Shallow orbits (HP:0000586)2.54564424
65Limb-girdle muscle weakness (HP:0003325)2.54170541
66Soft skin (HP:0000977)2.51108394
67Genu recurvatum (HP:0002816)2.49892048
68Type 1 muscle fiber predominance (HP:0003803)2.48269566
69Hand muscle atrophy (HP:0009130)2.47446344
70Hypsarrhythmia (HP:0002521)2.46020294
71Slender build (HP:0001533)2.45137476
72Menstrual irregularities (HP:0000858)2.43776017
73Scanning speech (HP:0002168)2.43017346
74Aortic regurgitation (HP:0001659)2.42414000
75Dysmetric saccades (HP:0000641)2.42089740
76Neurofibrillary tangles (HP:0002185)2.41961692
77Vascular tortuosity (HP:0004948)2.40522138
78Supranuclear gaze palsy (HP:0000605)2.40323080
79Poor eye contact (HP:0000817)2.36409170
80Excessive salivation (HP:0003781)2.36302506
81Drooling (HP:0002307)2.36302506
82Tibial bowing (HP:0002982)2.31540202
83Scotoma (HP:0000575)2.31493902
84Shoulder girdle muscle weakness (HP:0003547)2.31015393
85Abnormal rod and cone electroretinograms (HP:0008323)2.30437384
86Abnormality of ocular smooth pursuit (HP:0000617)2.30187208
87Wormian bones (HP:0002645)2.28905177
88Mitral regurgitation (HP:0001653)2.28349514
89Bowel diverticulosis (HP:0005222)2.27675303
90Hypercortisolism (HP:0001578)2.27501316
91Joint stiffness (HP:0001387)2.27285604
92Dysmetria (HP:0001310)2.24151789
93Spondylolisthesis (HP:0003302)2.23778570
94Impaired social interactions (HP:0000735)2.18829538
95Abnormal social behavior (HP:0012433)2.18829538
96Macroorchidism (HP:0000053)2.16502234
97J-shaped sella turcica (HP:0002680)2.16358803
98Round ear (HP:0100830)2.15429248
99Delayed gross motor development (HP:0002194)2.14732416
100Papilledema (HP:0001085)2.10598657
101Cerebral aneurysm (HP:0004944)2.09224190
102Prolonged QT interval (HP:0001657)2.07806008
103Thin bony cortex (HP:0002753)2.06550097
104Hyperinsulinemic hypoglycemia (HP:0000825)2.05752941
105Abnormal eating behavior (HP:0100738)2.05083540
106Biconcave vertebral bodies (HP:0004586)2.04800130
107Bony spicule pigmentary retinopathy (HP:0007737)2.03128153
108Postural tremor (HP:0002174)2.02810581
109Wrist flexion contracture (HP:0001239)2.02627185
110Short nail (HP:0001799)2.01617234
111Fragile skin (HP:0001030)2.00751486
112Amblyopia (HP:0000646)1.99697228
113Hypoplastic left heart (HP:0004383)1.99428031
114Hemiplegia (HP:0002301)1.98486505
115Asymmetric septal hypertrophy (HP:0001670)1.96038726
116Gait imbalance (HP:0002141)1.95779959
117Choroideremia (HP:0001139)1.95602648
118Protruding tongue (HP:0010808)1.94330130
119Broad metatarsal (HP:0001783)1.94169322
120Arterial tortuosity (HP:0005116)1.93929195
121Ventricular fibrillation (HP:0001663)1.90953645
122Hypoplastic heart (HP:0001961)1.90262350
123Ankyloglossia (HP:0010296)1.89933619
124Postural instability (HP:0002172)1.87610094
125Mutism (HP:0002300)1.86147961
126Congenital primary aphakia (HP:0007707)1.85891784
127Torticollis (HP:0000473)1.84689509
128Abnormality of the fovea (HP:0000493)1.83685155
129Ankle clonus (HP:0011448)1.83331390
130Generalized amyotrophy (HP:0003700)1.82594863
131Aortic valve stenosis (HP:0001650)1.82115987
132Mildly elevated creatine phosphokinase (HP:0008180)1.82054451
133Blue sclerae (HP:0000592)1.81979050
134Hyperacusis (HP:0010780)1.81718532
135Apathy (HP:0000741)1.81468858
136Cerebral inclusion bodies (HP:0100314)1.81370664
137Long toe (HP:0010511)1.81147804
138Increased circulating renin level (HP:0000848)1.81051061
139Stereotypic behavior (HP:0000733)1.80495153
140Pulmonary artery stenosis (HP:0004415)1.80282040
141Testicular neoplasm (HP:0010788)1.79252207
142Ulnar deviation of the wrist (HP:0003049)1.78615283
143Hyperextensible skin (HP:0000974)1.77908790
144Absent speech (HP:0001344)1.77333208
145Stridor (HP:0010307)1.75908865
146Loss of speech (HP:0002371)1.75752063
147Gonadal dysgenesis (HP:0000133)1.75640298
148Hypoplasia of the odontoid process (HP:0003311)1.75506689
149Decreased circulating renin level (HP:0003351)1.75484650
150Hypoglycemic seizures (HP:0002173)1.75015084
151Neoplasm of the heart (HP:0100544)1.74847616
152Hydroureter (HP:0000072)1.74638058
153Hammertoe (HP:0001765)1.74072708
154Protuberant abdomen (HP:0001538)1.74052665
155Diminished motivation (HP:0000745)1.73687298
156Flat cornea (HP:0007720)1.73672008
157Ovoid vertebral bodies (HP:0003300)1.73160229
158Wide anterior fontanel (HP:0000260)1.72775137
159Zonular cataract (HP:0010920)1.72336081
160Insomnia (HP:0100785)1.72243132
161Abnormal EKG (HP:0003115)1.72056444
162Abnormality of the lower motor neuron (HP:0002366)1.71719211
163Vitreoretinal degeneration (HP:0000655)1.71591608
164Intention tremor (HP:0002080)1.71358664
165Renal duplication (HP:0000075)1.70951538
166Focal dystonia (HP:0004373)1.70578635
167Hyperthyroidism (HP:0000836)1.70372464
168Growth hormone excess (HP:0000845)1.70244913
169Cardiovascular calcification (HP:0011915)1.69099189
170Buphthalmos (HP:0000557)1.68844323
171Severe visual impairment (HP:0001141)1.68797807
172Syncope (HP:0001279)1.67919084
173Dilatation of the ascending aorta (HP:0005111)1.67625035
174Type II diabetes mellitus (HP:0005978)1.66972354
175Beaking of vertebral bodies (HP:0004568)1.66070118
176Orthostatic hypotension (HP:0001278)1.66013274
177Generalized myoclonic seizures (HP:0002123)1.65894273
178Congenital glaucoma (HP:0001087)1.65742653
179Urinary bladder sphincter dysfunction (HP:0002839)1.65669043
180Abnormality of binocular vision (HP:0011514)1.65462693
181Diplopia (HP:0000651)1.65462693
182Absent frontal sinuses (HP:0002688)1.65143614
183Abnormality of the odontoid process (HP:0003310)1.65109697
184Mild short stature (HP:0003502)1.64041864
185Retinal dysplasia (HP:0007973)1.63141370
186Vacuolated lymphocytes (HP:0001922)1.63094747
187Hyperglycemia (HP:0003074)1.62630042
188Gait ataxia (HP:0002066)1.61999950
189Absent rod-and cone-mediated responses on ERG (HP:0007688)1.61775894
190Ectopia lentis (HP:0001083)1.61633452
191Impaired vibration sensation in the lower limbs (HP:0002166)1.61458852
192Abnormality of the musculature of the pelvis (HP:0001469)1.60845065
193Nephrogenic diabetes insipidus (HP:0009806)1.60511565
194Adrenal overactivity (HP:0002717)1.60093406
195Type II lissencephaly (HP:0007260)1.59954773
196Abnormality of the periventricular white matter (HP:0002518)1.59160832

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK34.52314926
2NTRK34.27429351
3IRAK34.14785402
4LIMK13.33712628
5TESK13.09766151
6MAP3K43.04938890
7TAOK22.71010710
8MAP2K72.67192416
9DAPK22.65518273
10EPHA42.60180023
11MOS2.55619199
12MAPK152.44864791
13CASK2.29139830
14PDGFRA2.21615579
15MAP3K92.16168446
16LATS22.07384092
17MYLK2.04215363
18PRKD32.00687653
19MINK11.98223057
20PIM21.94861487
21PAK61.89428158
22NME21.86744042
23PLK21.81992745
24EPHB21.77820354
25RIPK41.71700603
26MARK11.70859692
27DAPK11.70786770
28MAP3K121.70216645
29WNK41.68126106
30NEK91.66674610
31MAP2K41.62744448
32AKT31.61382831
33ADRBK21.59243301
34CCNB11.58295232
35CAMKK11.56906954
36CAMKK21.46839882
37KSR21.46341223
38NTRK21.46161381
39ABL21.44313957
40TTN1.42079746
41UHMK11.38606284
42KSR11.37613927
43TGFBR21.31995700
44PKN11.31265702
45MAP3K21.29759544
46SGK21.28602557
47SIK31.27233057
48WNK11.26100003
49ERBB41.25604468
50SGK2231.21819983
51SGK4941.21819983
52CDK51.21396099
53EPHA31.20440407
54NTRK11.19912027
55MAP3K31.19648531
56GRK51.19569395
57TAOK11.17111281
58TRIM281.17035967
59STK381.12331816
60INSRR1.09371907
61ROCK21.08086096
62PRKCG1.07989526
63PRPF4B1.03152817
64CLK11.03150200
65SGK31.02634074
66TNIK1.00911635
67PRKCH0.99534087
68CDC42BPA0.98370918
69CAMK2A0.98206833
70MAPK130.97653084
71MAP3K110.96949048
72PAK40.95995077
73PAK30.95792430
74PRKD20.95481950
75ARAF0.95241337
76ROCK10.95205395
77PHKG10.94054410
78PHKG20.94054410
79PIK3CG0.93838920
80SIK20.93374084
81DYRK1A0.92583535
82FER0.91382639
83RET0.90709877
84DMPK0.90403209
85SGK10.89950430
86TBK10.89929797
87CAMK10.88944466
88RIPK10.87052885
89CSNK1G30.83733129
90CAMK1G0.81606233
91CDK190.79731958
92CAMK2D0.77754347
93CAMK2B0.77185623
94PTK2B0.76633641
95MAP3K10.75174096
96PRKCE0.74889730
97PAK20.74875614
98CHUK0.74016222
99GSK3A0.69487965
100CSNK1A1L0.69251310
101PBK0.65072775
102MAP4K20.63926191
103MAP3K140.62551646
104SIK10.59942132
105ERBB30.59940343
106CAMK40.59773700
107MET0.58081581
108BMPR20.58009284
109GRK70.57599718
110CDK180.57041231
111CDK140.57028611
112CSNK1G10.56625765
113MAP3K50.56308903
114FES0.53654019
115PDGFRB0.53348974
116BCR0.53221089
117PAK10.52314245
118IKBKB0.51881441
119HIPK20.50885491
120RPS6KA30.50556450
121CDK150.50422219
122PINK10.50415518
123MARK20.50016955
124IRAK10.49399640
125DAPK30.49004408
126PTK20.48928873
127EPHB10.45376633
128RPS6KA20.43826679
129CDK30.43735293
130STK110.43444301
131TYRO30.42925249
132CDK11A0.42664422
133PRKCZ0.41340641
134FRK0.40901896
135MAPK70.40567415
136PDK10.40416511
137PRKG10.40378342
138PDPK10.39978697
139DDR20.37266937
140CAMK1D0.37071958
141ADRBK10.37038065
142CSNK1G20.35560377
143PNCK0.35367144
144PRKCA0.35361656
145OXSR10.34952939
146LMTK20.34925154
147STK100.34662349
148MAPK100.34480983
149CAMK2G0.34457107

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.38834532
2Synaptic vesicle cycle_Homo sapiens_hsa047213.16831261
3GABAergic synapse_Homo sapiens_hsa047272.78814338
4Circadian entrainment_Homo sapiens_hsa047132.67994079
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56136030
6Insulin secretion_Homo sapiens_hsa049112.52487735
7Morphine addiction_Homo sapiens_hsa050322.38598580
8Glutamatergic synapse_Homo sapiens_hsa047242.29618622
9Long-term potentiation_Homo sapiens_hsa047202.22706220
10Amphetamine addiction_Homo sapiens_hsa050312.14682327
11Phototransduction_Homo sapiens_hsa047442.13806489
12Olfactory transduction_Homo sapiens_hsa047402.11901486
13Malaria_Homo sapiens_hsa051442.11470783
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.09603819
15TNF signaling pathway_Homo sapiens_hsa046681.99120078
16Other glycan degradation_Homo sapiens_hsa005111.98301340
17Sulfur metabolism_Homo sapiens_hsa009201.93186018
18Salivary secretion_Homo sapiens_hsa049701.91069422
19Dopaminergic synapse_Homo sapiens_hsa047281.90849441
20Pertussis_Homo sapiens_hsa051331.90091445
21Salmonella infection_Homo sapiens_hsa051321.83113003
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79903402
23Collecting duct acid secretion_Homo sapiens_hsa049661.72159526
24African trypanosomiasis_Homo sapiens_hsa051431.71969443
25Cholinergic synapse_Homo sapiens_hsa047251.66602234
26Serotonergic synapse_Homo sapiens_hsa047261.65982189
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63034268
28Long-term depression_Homo sapiens_hsa047301.62601606
29ECM-receptor interaction_Homo sapiens_hsa045121.60598024
30Cocaine addiction_Homo sapiens_hsa050301.60250006
31Gastric acid secretion_Homo sapiens_hsa049711.60037681
32Renin secretion_Homo sapiens_hsa049241.59574824
33Oxytocin signaling pathway_Homo sapiens_hsa049211.56907070
34Taste transduction_Homo sapiens_hsa047421.56112021
35Amoebiasis_Homo sapiens_hsa051461.51584714
36Type II diabetes mellitus_Homo sapiens_hsa049301.51454931
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47423406
38Folate biosynthesis_Homo sapiens_hsa007901.46212341
39Vibrio cholerae infection_Homo sapiens_hsa051101.44317019
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.41822007
41Calcium signaling pathway_Homo sapiens_hsa040201.39993055
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39892438
43cAMP signaling pathway_Homo sapiens_hsa040241.38301354
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37975673
45Focal adhesion_Homo sapiens_hsa045101.32709845
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31842762
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29417161
48GnRH signaling pathway_Homo sapiens_hsa049121.28691241
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28346553
50TGF-beta signaling pathway_Homo sapiens_hsa043501.28215508
51Bladder cancer_Homo sapiens_hsa052191.22122260
52Legionellosis_Homo sapiens_hsa051341.20347954
53Type I diabetes mellitus_Homo sapiens_hsa049401.16220472
54Sphingolipid metabolism_Homo sapiens_hsa006001.15851738
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.15609247
56Gap junction_Homo sapiens_hsa045401.15191243
57NF-kappa B signaling pathway_Homo sapiens_hsa040641.14489649
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14129816
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13305678
60Vascular smooth muscle contraction_Homo sapiens_hsa042701.12146417
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11665098
62Shigellosis_Homo sapiens_hsa051311.09430706
63Steroid biosynthesis_Homo sapiens_hsa001001.08015261
64Circadian rhythm_Homo sapiens_hsa047101.06075672
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06037734
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05981552
67Dilated cardiomyopathy_Homo sapiens_hsa054141.04751321
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04023138
69Estrogen signaling pathway_Homo sapiens_hsa049151.03977360
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03582768
71Proteoglycans in cancer_Homo sapiens_hsa052051.00515627
72NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99871661
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98916671
74Cardiac muscle contraction_Homo sapiens_hsa042600.94973030
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94713054
76Thyroid hormone synthesis_Homo sapiens_hsa049180.91269609
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.90181305
78Pancreatic secretion_Homo sapiens_hsa049720.89590077
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86830493
80Axon guidance_Homo sapiens_hsa043600.84735275
81Melanogenesis_Homo sapiens_hsa049160.84249028
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83103849
83Dorso-ventral axis formation_Homo sapiens_hsa043200.81530232
84Glioma_Homo sapiens_hsa052140.80093766
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79717672
86Osteoclast differentiation_Homo sapiens_hsa043800.76100435
87Glucagon signaling pathway_Homo sapiens_hsa049220.75653822
88ErbB signaling pathway_Homo sapiens_hsa040120.75109780
89Hippo signaling pathway_Homo sapiens_hsa043900.74510780
90Ovarian steroidogenesis_Homo sapiens_hsa049130.73599710
91Melanoma_Homo sapiens_hsa052180.71771888
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71345274
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70945611
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68718796
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68223516
96Hedgehog signaling pathway_Homo sapiens_hsa043400.67080621
97Protein digestion and absorption_Homo sapiens_hsa049740.66510030
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65802704
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64754976
100MAPK signaling pathway_Homo sapiens_hsa040100.63598218
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.62956165
102Fatty acid elongation_Homo sapiens_hsa000620.62636525
103Hepatitis C_Homo sapiens_hsa051600.60161105
104Complement and coagulation cascades_Homo sapiens_hsa046100.59641062
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57498429
106Galactose metabolism_Homo sapiens_hsa000520.57169937
107Choline metabolism in cancer_Homo sapiens_hsa052310.56257061
108Jak-STAT signaling pathway_Homo sapiens_hsa046300.55191536
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54908538
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53831166
111Rheumatoid arthritis_Homo sapiens_hsa053230.53733159
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.53624711
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53249531
114Inositol phosphate metabolism_Homo sapiens_hsa005620.53081611
115Hepatitis B_Homo sapiens_hsa051610.52960471
116Tuberculosis_Homo sapiens_hsa051520.52796457
117Prion diseases_Homo sapiens_hsa050200.50222077
118MicroRNAs in cancer_Homo sapiens_hsa052060.49800129
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.49714136
120Basal cell carcinoma_Homo sapiens_hsa052170.48760295
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48036902
122Adherens junction_Homo sapiens_hsa045200.47373528
123Protein export_Homo sapiens_hsa030600.47269456
124Renal cell carcinoma_Homo sapiens_hsa052110.45897679
125Ras signaling pathway_Homo sapiens_hsa040140.45617245
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45588638
127mTOR signaling pathway_Homo sapiens_hsa041500.44915880
128Insulin signaling pathway_Homo sapiens_hsa049100.43838613
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42983432
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42973588
131Rap1 signaling pathway_Homo sapiens_hsa040150.41496483
132Glutathione metabolism_Homo sapiens_hsa004800.41196236
133Small cell lung cancer_Homo sapiens_hsa052220.40849812
134Toxoplasmosis_Homo sapiens_hsa051450.40504916
135Wnt signaling pathway_Homo sapiens_hsa043100.40044311
136Mineral absorption_Homo sapiens_hsa049780.39579936
137Phagosome_Homo sapiens_hsa041450.39526011
138Oocyte meiosis_Homo sapiens_hsa041140.37658214
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35662113
140Alzheimers disease_Homo sapiens_hsa050100.35342265
141Alcoholism_Homo sapiens_hsa050340.33586791
142Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32491111
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31793869
144Chemokine signaling pathway_Homo sapiens_hsa040620.31388682
145Lysosome_Homo sapiens_hsa041420.31238769
146Bile secretion_Homo sapiens_hsa049760.30723849
147Sphingolipid signaling pathway_Homo sapiens_hsa040710.30030281
148Endocytosis_Homo sapiens_hsa041440.29343383
149Oxidative phosphorylation_Homo sapiens_hsa001900.26252097
150VEGF signaling pathway_Homo sapiens_hsa043700.26156160
151Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25387905
152Endometrial cancer_Homo sapiens_hsa052130.24542974
153Glycosaminoglycan degradation_Homo sapiens_hsa005310.24392260

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