MAN1A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis of three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1very-low-density lipoprotein particle assembly (GO:0034379)5.96506475
2regulation of fibrinolysis (GO:0051917)5.91885705
3regulation of protein activation cascade (GO:2000257)5.67819018
4negative regulation of fibrinolysis (GO:0051918)5.67312453
5regulation of complement activation (GO:0030449)5.59584809
6low-density lipoprotein particle remodeling (GO:0034374)5.49812962
7plasma lipoprotein particle assembly (GO:0034377)5.40938482
8peptidyl-glutamic acid carboxylation (GO:0017187)5.28097916
9protein carboxylation (GO:0018214)5.28097916
10protein-lipid complex assembly (GO:0065005)4.88026629
11negative regulation of protein activation cascade (GO:2000258)4.81222771
12plasma lipoprotein particle remodeling (GO:0034369)4.76428437
13protein-lipid complex remodeling (GO:0034368)4.76428437
14macromolecular complex remodeling (GO:0034367)4.76428437
15intestinal cholesterol absorption (GO:0030299)4.73693758
16cholesterol efflux (GO:0033344)4.73626200
17regulation of cholesterol esterification (GO:0010872)4.66014849
18L-phenylalanine catabolic process (GO:0006559)4.61595276
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.61595276
20plasma lipoprotein particle organization (GO:0071827)4.49014529
21complement activation, alternative pathway (GO:0006957)4.48637610
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.42664433
23L-phenylalanine metabolic process (GO:0006558)4.42664433
24high-density lipoprotein particle remodeling (GO:0034375)4.33309890
25blood coagulation, intrinsic pathway (GO:0007597)4.27176182
26negative regulation of complement activation (GO:0045916)4.26885099
27protein-lipid complex subunit organization (GO:0071825)4.25724667
28regulation of bile acid biosynthetic process (GO:0070857)4.15382080
29reverse cholesterol transport (GO:0043691)4.14391436
30plasma lipoprotein particle clearance (GO:0034381)4.09090794
31intestinal absorption (GO:0050892)4.06649687
32regulation of cholesterol homeostasis (GO:2000188)4.06003844
33low-density lipoprotein particle clearance (GO:0034383)3.90991363
34regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.90803026
35regulation of extracellular matrix disassembly (GO:0010715)3.90061244
36regulation of apoptotic cell clearance (GO:2000425)3.88649478
37triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.74589497
38COPII vesicle coating (GO:0048208)3.67694313
39complement activation, classical pathway (GO:0006958)3.64766223
40lipoprotein transport (GO:0042953)3.62357358
41lipoprotein metabolic process (GO:0042157)3.56430631
42protein activation cascade (GO:0072376)3.54078765
43phospholipid efflux (GO:0033700)3.43607876
44ethanol oxidation (GO:0006069)3.41344666
45acute-phase response (GO:0006953)3.39056208
46negative regulation of humoral immune response (GO:0002921)3.37476991
47negative regulation of cholesterol transport (GO:0032375)3.36346730
48negative regulation of sterol transport (GO:0032372)3.36346730
49regulation of plasminogen activation (GO:0010755)3.35417413
50acylglycerol homeostasis (GO:0055090)3.33075967
51triglyceride homeostasis (GO:0070328)3.33075967
52regulation of humoral immune response (GO:0002920)3.31686648
53positive regulation of steroid metabolic process (GO:0045940)3.31020028
54cholesterol transport (GO:0030301)3.30297177
55sterol transport (GO:0015918)3.30297177
56positive regulation of blood coagulation (GO:0030194)3.26229193
57positive regulation of hemostasis (GO:1900048)3.26229193
58diacylglycerol metabolic process (GO:0046339)3.22625528
59oligosaccharide catabolic process (GO:0009313)3.22014381
60angiotensin maturation (GO:0002003)3.19675061
61positive regulation of coagulation (GO:0050820)3.18109841
62complement activation (GO:0006956)3.16134455
63glutamate metabolic process (GO:0006536)3.11462613
64cholesterol homeostasis (GO:0042632)3.10920155
65phospholipid homeostasis (GO:0055091)3.08614637
66epoxygenase P450 pathway (GO:0019373)3.08431647
67sterol homeostasis (GO:0055092)3.07867959
68positive regulation of lipoprotein lipase activity (GO:0051006)2.97888830
69positive regulation of triglyceride lipase activity (GO:0061365)2.97888830
70negative regulation of hemostasis (GO:1900047)2.94795347
71negative regulation of blood coagulation (GO:0030195)2.94795347
72cellular zinc ion homeostasis (GO:0006882)2.93113187
73cellular response to ethanol (GO:0071361)2.91421064
74positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.90838248
75regulation of extracellular matrix organization (GO:1903053)2.90712944
76dicarboxylic acid biosynthetic process (GO:0043650)2.90220061
77fibrinolysis (GO:0042730)2.84058139
78positive regulation of fatty acid biosynthetic process (GO:0045723)2.83976411
79positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.80511622
80lipid homeostasis (GO:0055088)2.78094506
81positive regulation of extracellular matrix organization (GO:1903055)2.76399947
82peptide hormone processing (GO:0016486)2.75142809
83cellular glucuronidation (GO:0052695)2.74652752
84regulation of cholesterol storage (GO:0010885)2.74370204
85aromatic amino acid family catabolic process (GO:0009074)2.73262563
86negative regulation of coagulation (GO:0050819)2.71331891
87regulation of cholesterol metabolic process (GO:0090181)2.69023607
88regulation of cholesterol biosynthetic process (GO:0045540)2.68355426
89glutamine family amino acid biosynthetic process (GO:0009084)2.67304462
90embryonic retina morphogenesis in camera-type eye (GO:0060059)2.62694598
91neutral lipid catabolic process (GO:0046461)2.62282124
92acylglycerol catabolic process (GO:0046464)2.62282124
93ethanol metabolic process (GO:0006067)2.62265603
94negative regulation of wound healing (GO:0061045)2.61275584
95positive regulation of hormone biosynthetic process (GO:0046886)2.60171408
96urea metabolic process (GO:0019627)2.53759891
97alpha-linolenic acid metabolic process (GO:0036109)2.53493062
98regulation of fatty acid biosynthetic process (GO:0042304)2.53343527
99negative regulation of fatty acid transport (GO:2000192)2.53294074
100fatty acid homeostasis (GO:0055089)2.50790924

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.41477598
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.27684620
3LXR_22158963_ChIP-Seq_LIVER_Mouse3.97038813
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.54343542
5* FOXA2_19822575_ChIP-Seq_HepG2_Human3.18315538
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.03858681
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.90026248
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.83648707
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.78626929
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.73752621
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.61983203
12GATA1_22025678_ChIP-Seq_K562_Human2.52009401
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.50899606
14SALL4_18804426_ChIP-ChIP_XEN_Mouse2.21772987
15* HNF4A_19822575_ChIP-Seq_HepG2_Human2.17489529
16FOXO3_23340844_ChIP-Seq_DLD1_Human2.15565521
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.14059447
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.13790037
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.09032618
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.07445414
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.94620769
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92480827
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87384308
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.86418843
25CLOCK_20551151_ChIP-Seq_293T_Human1.83597888
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74269317
27FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.72316815
28SOX2_27498859_Chip-Seq_STOMACH_Mouse1.71962325
29GATA4_25053715_ChIP-Seq_YYC3_Human1.67599248
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.58783193
31TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.58044662
32CDX2_20551321_ChIP-Seq_CACO-2_Human1.57892735
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56773933
34* GATA1_19941826_ChIP-Seq_K562_Human1.56665339
35SOX2_20726797_ChIP-Seq_SW620_Human1.54145394
36* GATA2_19941826_ChIP-Seq_K562_Human1.51934722
37TCF4_18268006_ChIP-ChIP_LS174T_Human1.51784561
38FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.51463395
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47927525
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.47587275
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.47408568
42CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.46658022
43ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.39801375
44* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39478586
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38448967
46FOXA1_25552417_ChIP-Seq_VCAP_Human1.32303961
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32142383
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32021531
49GATA6_25053715_ChIP-Seq_YYC3_Human1.31312596
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.30938478
51AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.30852068
52* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29194755
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27835484
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21577304
55FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19626499
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13976719
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04702008
58CDX2_22108803_ChIP-Seq_LS180_Human1.04047712
59RUNX_20019798_ChIP-Seq_JUKART_Human1.03867504
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02252298
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02131543
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02131543
63* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01541670
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01307116
65ZNF263_19887448_ChIP-Seq_K562_Human0.97650028
66* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93831401
67* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92961063
68* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92310113
69VDR_24787735_ChIP-Seq_THP-1_Human0.91393667
70GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91098836
71MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.90956824
72HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90817192
73ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90259522
74BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89161871
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87746072
76EP300_21415370_ChIP-Seq_HL-1_Mouse0.87323149
77GATA1_19941827_ChIP-Seq_MEL_Mouse0.86848691
78STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.86730622
79* SPI1_23127762_ChIP-Seq_K562_Human0.86664310
80GATA3_24758297_ChIP-Seq_MCF-7_Human0.86194819
81FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.85692297
82* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84548546
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84445415
84SMAD1_18555785_Chip-Seq_ESCs_Mouse0.82897353
85NFIB_24661679_ChIP-Seq_LUNG_Mouse0.81197319
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.81014523
87PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79784784
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79775186
89PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79663528
90FLI1_27457419_Chip-Seq_LIVER_Mouse0.78273820
91FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.78225772
92PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.77823445
93* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.77805031
94GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.76718743
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.75828147
96RARG_19884340_ChIP-ChIP_MEFs_Mouse0.75797982
97CJUN_26792858_Chip-Seq_BT549_Human0.75773670
98PIAS1_25552417_ChIP-Seq_VCAP_Human0.75647671
99GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75138213
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.74857073

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.02423823
2MP0005365_abnormal_bile_salt4.04819957
3MP0003195_calcinosis3.81561029
4MP0005360_urolithiasis3.75247343
5MP0005085_abnormal_gallbladder_physiolo3.37257057
6MP0010329_abnormal_lipoprotein_level3.25528739
7MP0001666_abnormal_nutrient_absorption2.94137846
8MP0003252_abnormal_bile_duct2.73965502
9MP0003122_maternal_imprinting2.56384775
10MP0003868_abnormal_feces_composition2.38602408
11MP0009840_abnormal_foam_cell2.35664349
12MP0003172_abnormal_lysosome_physiology2.32177914
13MP0005058_abnormal_lysosome_morphology2.30056213
14MP0005451_abnormal_body_composition2.13468129
15MP0009780_abnormal_chondrocyte_physiolo2.07345905
16MP0006054_spinal_hemorrhage2.04760197
17MP0010234_abnormal_vibrissa_follicle2.01225317
18MP0002166_altered_tumor_susceptibility1.96493919
19MP0008875_abnormal_xenobiotic_pharmacok1.87059507
20MP0003656_abnormal_erythrocyte_physiolo1.84955479
21MP0005464_abnormal_platelet_physiology1.79894544
22MP0002909_abnormal_adrenal_gland1.79390509
23MP0005332_abnormal_amino_acid1.79109330
24MP0005379_endocrine/exocrine_gland_phen1.79028073
25MP0002118_abnormal_lipid_homeostasis1.77238085
26MP0008438_abnormal_cutaneous_collagen1.76536197
27MP0000609_abnormal_liver_physiology1.72169238
28MP0002876_abnormal_thyroid_physiology1.62845859
29MP0004019_abnormal_vitamin_homeostasis1.62302445
30MP0003191_abnormal_cellular_cholesterol1.57428924
31MP0002138_abnormal_hepatobiliary_system1.54410738
32MP0003300_gastrointestinal_ulcer1.52789641
33MP0003183_abnormal_peptide_metabolism1.45290239
34MP0000013_abnormal_adipose_tissue1.44697570
35MP0002971_abnormal_brown_adipose1.44693878
36MP0005220_abnormal_exocrine_pancreas1.41312527
37MP0002132_abnormal_respiratory_system1.40865875
38MP0005636_abnormal_mineral_homeostasis1.38421538
39MP0005408_hypopigmentation1.38035716
40MP0001661_extended_life_span1.30668042
41MP0002078_abnormal_glucose_homeostasis1.30333343
42MP0004264_abnormal_extraembryonic_tissu1.30265821
43MP0005409_darkened_coat_color1.28503671
44MP0000604_amyloidosis1.27675069
45MP0001756_abnormal_urination1.26985683
46MP0001944_abnormal_pancreas_morphology1.24267466
47MP0009643_abnormal_urine_homeostasis1.23171338
48MP0002693_abnormal_pancreas_physiology1.19701779
49MP0001915_intracranial_hemorrhage1.12109159
50MP0002006_tumorigenesis1.10037410
51MP0010368_abnormal_lymphatic_system1.09808394
52MP0000003_abnormal_adipose_tissue1.08659215
53MP0000598_abnormal_liver_morphology1.07944514
54MP0009115_abnormal_fat_cell1.07437664
55MP0003303_peritoneal_inflammation1.03607577
56MP0003123_paternal_imprinting1.03515462
57MP0005164_abnormal_response_to1.01720286
58MP0005448_abnormal_energy_balance1.00406079
59MP0002009_preneoplasia0.98824329
60MP0000685_abnormal_immune_system0.98463315
61MP0008469_abnormal_protein_level0.97627804
62MP0009642_abnormal_blood_homeostasis0.97093985
63MP0005319_abnormal_enzyme/_coenzyme0.96517301
64MP0010352_gastrointestinal_tract_polyps0.95189344
65MP0003690_abnormal_glial_cell0.93468608
66MP0001764_abnormal_homeostasis0.91985862
67MP0001765_abnormal_ion_homeostasis0.90554116
68MP0003953_abnormal_hormone_level0.87313853
69MP0000639_abnormal_adrenal_gland0.87175550
70MP0002933_joint_inflammation0.87158383
71MP0005670_abnormal_white_adipose0.86225507
72MP0005375_adipose_tissue_phenotype0.86156965
73MP0002396_abnormal_hematopoietic_system0.82537417
74MP0005666_abnormal_adipose_tissue0.82037715
75MP0004043_abnormal_pH_regulation0.80081034
76MP0003436_decreased_susceptibility_to0.79756039
77MP0003724_increased_susceptibility_to0.79223051
78MP0004883_abnormal_blood_vessel0.77416667
79MP0005084_abnormal_gallbladder_morpholo0.76183304
80MP0002136_abnormal_kidney_physiology0.75757645
81MP0005535_abnormal_body_temperature0.75005500
82MP0006082_CNS_inflammation0.73632373
83MP0005584_abnormal_enzyme/coenzyme_acti0.71104073
84MP0001835_abnormal_antigen_presentation0.70729965
85MP0004272_abnormal_basement_membrane0.70164489
86MP0005167_abnormal_blood-brain_barrier0.69032343
87MP0002168_other_aberrant_phenotype0.68996639
88MP0009697_abnormal_copulation0.68749240
89MP0010155_abnormal_intestine_physiology0.68717613
90MP0002998_abnormal_bone_remodeling0.66748547
91MP0003943_abnormal_hepatobiliary_system0.65733206
92MP0009785_altered_susceptibility_to0.64091655
93MP0003329_amyloid_beta_deposits0.63047428
94MP0008004_abnormal_stomach_pH0.62908093
95MP0001845_abnormal_inflammatory_respons0.62683200
96MP0005334_abnormal_fat_pad0.61318908
97MP0003866_abnormal_defecation0.60701902
98MP0000249_abnormal_blood_vessel0.59339167
99MP0005376_homeostasis/metabolism_phenot0.59054198
100MP0002970_abnormal_white_adipose0.58926858

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.78897679
2Hypobetalipoproteinemia (HP:0003563)5.78469456
3Complement deficiency (HP:0004431)5.43657999
4Prolonged partial thromboplastin time (HP:0003645)5.32317786
5Abnormality of the common coagulation pathway (HP:0010990)4.83528004
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.55579607
7Joint hemorrhage (HP:0005261)4.54250328
8Abnormality of complement system (HP:0005339)4.31571652
9Xanthomatosis (HP:0000991)4.22424097
10Glomerulonephritis (HP:0000099)4.06061377
11Systemic lupus erythematosus (HP:0002725)3.80089320
12Acanthocytosis (HP:0001927)3.76131051
13Gingival bleeding (HP:0000225)3.65547150
14Vascular calcification (HP:0004934)3.59434967
15Hypolipoproteinemia (HP:0010981)3.46464039
16Fat malabsorption (HP:0002630)3.37741222
17Cardiovascular calcification (HP:0011915)3.36820526
18Mitral stenosis (HP:0001718)3.24764198
19Hypercholesterolemia (HP:0003124)3.17254825
20Spontaneous abortion (HP:0005268)3.05732448
21Abnormality of monocarboxylic acid metabolism (HP:0010996)2.98416857
22Menorrhagia (HP:0000132)2.97307878
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.88949238
24Urinary glycosaminoglycan excretion (HP:0003541)2.80208723
25Mucopolysacchariduria (HP:0008155)2.80208723
26Proximal tubulopathy (HP:0000114)2.80012458
27Skin nodule (HP:0200036)2.78029749
28Myocardial infarction (HP:0001658)2.74813578
29Epidermoid cyst (HP:0200040)2.74757364
30Hemorrhage of the eye (HP:0011885)2.72662670
31Hypoglycemic coma (HP:0001325)2.70728143
32Recurrent gram-negative bacterial infections (HP:0005420)2.66455877
33Abnormality of mucopolysaccharide metabolism (HP:0011020)2.65603866
34Abnormality of polysaccharide metabolism (HP:0011012)2.65603866
35Abnormality of glycosaminoglycan metabolism (HP:0004371)2.65603866
36Pancreatic islet-cell hyperplasia (HP:0004510)2.63902530
37Purpura (HP:0000979)2.59908697
38Conjugated hyperbilirubinemia (HP:0002908)2.55556265
39Poikilocytosis (HP:0004447)2.55234605
40Asymmetry of the thorax (HP:0001555)2.51830732
41Intrahepatic cholestasis (HP:0001406)2.43567061
42Prolonged bleeding time (HP:0003010)2.39047651
43Hyperlipoproteinemia (HP:0010980)2.37842579
44Orthostatic hypotension (HP:0001278)2.36073239
45Abnormality of endocrine pancreas physiology (HP:0012093)2.35522439
46Abnormality of the pancreatic islet cells (HP:0006476)2.35522439
47Nephritis (HP:0000123)2.34396332
48Hypoglycemic seizures (HP:0002173)2.33494332
49Steatorrhea (HP:0002570)2.32824916
50Hyperglycemia (HP:0003074)2.31837120
51Abnormal tarsal ossification (HP:0008369)2.29424059
52Dysostosis multiplex (HP:0000943)2.26856490
53Abnormality of glutamine family amino acid metabolism (HP:0010902)2.23155778
54Facial shape deformation (HP:0011334)2.21511972
55Potter facies (HP:0002009)2.21511972
56Testicular neoplasm (HP:0010788)2.19194185
57Flat acetabular roof (HP:0003180)2.18806826
58Increased CSF protein (HP:0002922)2.17347267
59Polycythemia (HP:0001901)2.17134464
60Peritonitis (HP:0002586)2.16842960
61Hypotension (HP:0002615)2.16631463
62Abnormality of the intrinsic pathway (HP:0010989)2.16472941
63Pigmentary retinal degeneration (HP:0001146)2.15759247
64Epistaxis (HP:0000421)2.15418845
65Rickets (HP:0002748)2.15142923
66Abnormality of carpal bone ossification (HP:0006257)2.10828094
67Thrombophlebitis (HP:0004418)2.09994891
68Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.08626357
69Osteomalacia (HP:0002749)2.08472036
70Hydroxyprolinuria (HP:0003080)2.08368463
71Abnormality of proline metabolism (HP:0010907)2.08368463
72Vacuolated lymphocytes (HP:0001922)2.07758788
73Hypophosphatemic rickets (HP:0004912)2.06033886
74Joint swelling (HP:0001386)2.05620909
75Episodic fever (HP:0001954)2.03858909
76Hepatocellular carcinoma (HP:0001402)2.02289296
77Hyperinsulinemic hypoglycemia (HP:0000825)1.98034263
78Gastrointestinal infarctions (HP:0005244)1.97439491
79Amyloidosis (HP:0011034)1.96422002
80Hypothermia (HP:0002045)1.96216290
81Abnormality of vitamin metabolism (HP:0100508)1.90145203
82Ovoid vertebral bodies (HP:0003300)1.89646371
83Abnormality of the lumbar spine (HP:0100712)1.89137668
84Arthropathy (HP:0003040)1.88849663
85Late onset (HP:0003584)1.87475732
86Striae distensae (HP:0001065)1.86153032
87Ketoacidosis (HP:0001993)1.82052880
88Pulmonary embolism (HP:0002204)1.81465883
89Papillary thyroid carcinoma (HP:0002895)1.80835144
90Broad palm (HP:0001169)1.78458163
91Abnormal foot bone ossification (HP:0010675)1.78314405
92Hypoalphalipoproteinemia (HP:0003233)1.74787847
93Broad alveolar ridges (HP:0000187)1.70644263
94Glycosuria (HP:0003076)1.70428763
95Abnormality of urine glucose concentration (HP:0011016)1.70428763
96Coarse hair (HP:0002208)1.67558131
97Hypophosphatemia (HP:0002148)1.65932862
98Overlapping toe (HP:0001845)1.64158772
99Flared iliac wings (HP:0002869)1.62534099
100Small epiphyses (HP:0010585)1.62479523

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR34.66246469
2FGFR44.31939877
3ERN12.84184620
4MAP3K22.47551362
5FRK2.41381353
6TRPM72.06594769
7AKT32.03320565
8ICK1.81785909
9ACVR1B1.80739156
10MAP2K31.75975015
11FGFR21.72963674
12WNK41.72683572
13PIK3CG1.62745493
14CDK121.60059360
15WNK11.58454946
16TYK21.57505576
17PRKAA21.56253264
18MAP3K11.53500827
19NLK1.53456486
20EEF2K1.45802501
21RET1.42833620
22PKN21.41554030
23BMPR21.37551917
24MAP3K141.32431977
25JAK11.31296091
26SCYL21.29363862
27PDPK11.29360599
28EPHA31.29308618
29KSR21.25837797
30RIPK11.25185161
31STK31.23186596
32MAP3K131.20545261
33RIPK41.19312539
34PIK3CA1.19220761
35MAPK111.19096366
36EIF2AK31.17860806
37EIF2AK11.14917048
38PDK11.12994740
39PDGFRA1.11308367
40TGFBR21.10285114
41MAP2K61.06048026
42SGK31.02444190
43STK241.00304716
44TRIB31.00278178
45STK390.98695771
46LATS10.98159628
47MAP3K60.97614118
48HIPK20.97133868
49PRPF4B0.96844183
50SGK20.93488720
51FGFR10.90841050
52IRAK30.89482079
53YES10.88322559
54CDK60.85418374
55CDC42BPA0.85160183
56CSF1R0.84468711
57JAK20.83168572
58IRAK10.78953310
59PRKG20.78556914
60NTRK30.78313980
61FER0.78111528
62DDR20.75798921
63JAK30.75450466
64RPS6KB10.74910640
65STK40.74067942
66ZAP700.71368668
67KIT0.70699115
68NEK90.68486978
69FGR0.68053800
70MST40.65385609
71FLT30.61848207
72ITK0.61473211
73SGK10.60815614
74TBK10.60639671
75SGK2230.59031837
76SGK4940.59031837
77SYK0.58191446
78PRKAA10.56932022
79MAPKAPK30.56410814
80MATK0.56067166
81EPHB10.52918392
82BRD40.52626150
83BRSK20.49258480
84MAP3K70.48748578
85PTK60.48469920
86MAP3K30.47132013
87MAP3K50.45627322
88MAP3K90.44991340
89GRK60.44862679
90TAOK30.44013753
91GSK3A0.43385577
92ERBB20.42644207
93DAPK20.42083097
94PRKACG0.40892341
95IKBKE0.40839035
96MAP3K120.39374073
97MAP2K40.39259640
98SIK10.37544095
99LYN0.36656438
100BLK0.36356272

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046104.42357687
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.73482626
3Other glycan degradation_Homo sapiens_hsa005112.52809760
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.50600846
5Fat digestion and absorption_Homo sapiens_hsa049752.46929150
6Arginine biosynthesis_Homo sapiens_hsa002202.25804451
7Staphylococcus aureus infection_Homo sapiens_hsa051502.11683340
8Fatty acid degradation_Homo sapiens_hsa000712.06062650
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05588394
10PPAR signaling pathway_Homo sapiens_hsa033201.95010311
11Starch and sucrose metabolism_Homo sapiens_hsa005001.83174983
12Renin-angiotensin system_Homo sapiens_hsa046141.81606974
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.78786777
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.74887494
15Retinol metabolism_Homo sapiens_hsa008301.74691963
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.73638714
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.72567216
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.70678023
19Vitamin digestion and absorption_Homo sapiens_hsa049771.70517291
20Fatty acid biosynthesis_Homo sapiens_hsa000611.64339544
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.64178519
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63645902
23Histidine metabolism_Homo sapiens_hsa003401.60069543
24Fatty acid metabolism_Homo sapiens_hsa012121.60044051
25ABC transporters_Homo sapiens_hsa020101.55708359
26Butanoate metabolism_Homo sapiens_hsa006501.46158295
27Chemical carcinogenesis_Homo sapiens_hsa052041.37269846
28Sulfur metabolism_Homo sapiens_hsa009201.35233458
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.34334626
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.33410092
31Caffeine metabolism_Homo sapiens_hsa002321.32318334
32Bile secretion_Homo sapiens_hsa049761.28610269
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28557362
34Vitamin B6 metabolism_Homo sapiens_hsa007501.24297306
35Sphingolipid metabolism_Homo sapiens_hsa006001.22638758
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.22233061
37Phenylalanine metabolism_Homo sapiens_hsa003601.20027342
38Tryptophan metabolism_Homo sapiens_hsa003801.17991297
39Tyrosine metabolism_Homo sapiens_hsa003501.04285582
40Adipocytokine signaling pathway_Homo sapiens_hsa049200.95244599
41Peroxisome_Homo sapiens_hsa041460.94163882
42Insulin resistance_Homo sapiens_hsa049310.92737687
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91393463
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89574522
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89557095
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.86787457
47Mineral absorption_Homo sapiens_hsa049780.85876897
48Lysosome_Homo sapiens_hsa041420.85384042
49Glycerolipid metabolism_Homo sapiens_hsa005610.76554263
50Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76434655
51* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76091929
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72808396
53Pertussis_Homo sapiens_hsa051330.72631128
54Glucagon signaling pathway_Homo sapiens_hsa049220.67390506
55Fructose and mannose metabolism_Homo sapiens_hsa000510.65947558
56Glycerophospholipid metabolism_Homo sapiens_hsa005640.64590962
57Propanoate metabolism_Homo sapiens_hsa006400.64371818
58Thyroid hormone synthesis_Homo sapiens_hsa049180.64334273
59Prion diseases_Homo sapiens_hsa050200.62739440
60Galactose metabolism_Homo sapiens_hsa000520.59447778
61Steroid biosynthesis_Homo sapiens_hsa001000.57741589
62Protein digestion and absorption_Homo sapiens_hsa049740.57411988
63Type II diabetes mellitus_Homo sapiens_hsa049300.55619095
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54783362
65Arginine and proline metabolism_Homo sapiens_hsa003300.54716566
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54635382
67Inositol phosphate metabolism_Homo sapiens_hsa005620.54258565
68Ether lipid metabolism_Homo sapiens_hsa005650.51966770
69Non-small cell lung cancer_Homo sapiens_hsa052230.51693336
70Type I diabetes mellitus_Homo sapiens_hsa049400.48648107
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48422689
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47767257
73Fatty acid elongation_Homo sapiens_hsa000620.47535424
74* N-Glycan biosynthesis_Homo sapiens_hsa005100.46902696
75Arachidonic acid metabolism_Homo sapiens_hsa005900.45778080
76Platelet activation_Homo sapiens_hsa046110.45574668
77mTOR signaling pathway_Homo sapiens_hsa041500.45349256
78Renin secretion_Homo sapiens_hsa049240.42315294
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42188024
80Linoleic acid metabolism_Homo sapiens_hsa005910.41619414
81AMPK signaling pathway_Homo sapiens_hsa041520.40035897
82Prolactin signaling pathway_Homo sapiens_hsa049170.39338250
83B cell receptor signaling pathway_Homo sapiens_hsa046620.38945358
84Insulin signaling pathway_Homo sapiens_hsa049100.38914679
85Hepatitis C_Homo sapiens_hsa051600.36184310
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.36112404
87FoxO signaling pathway_Homo sapiens_hsa040680.34965593
88African trypanosomiasis_Homo sapiens_hsa051430.32397136
89Lysine degradation_Homo sapiens_hsa003100.31840238
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.28927284
91beta-Alanine metabolism_Homo sapiens_hsa004100.28213890
92Leishmaniasis_Homo sapiens_hsa051400.26712899
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25176748
94Glutathione metabolism_Homo sapiens_hsa004800.23979305
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.23894946
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.22178837
97Insulin secretion_Homo sapiens_hsa049110.21933839
98Amoebiasis_Homo sapiens_hsa051460.19327588
99Pancreatic secretion_Homo sapiens_hsa049720.19273207
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18976201

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