MAN1A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Alpha-mannosidases function at different stages of N-glycan maturation in mammalian cells. See MAN2A1 (MIM 154582) for general information. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)4.58911235
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.10853159
3cytoplasmic mRNA processing body assembly (GO:0033962)3.96617839
4behavioral response to nicotine (GO:0035095)3.96122984
5vocalization behavior (GO:0071625)3.93696090
6regulation of Rac protein signal transduction (GO:0035020)3.83257760
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.82027789
8glutamate secretion (GO:0014047)3.79584969
9synaptic vesicle maturation (GO:0016188)3.77251964
10layer formation in cerebral cortex (GO:0021819)3.60282913
11synaptic vesicle exocytosis (GO:0016079)3.50644858
12central nervous system projection neuron axonogenesis (GO:0021952)3.49536175
13dendritic spine morphogenesis (GO:0060997)3.49357348
14exploration behavior (GO:0035640)3.48878588
15positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.44943880
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.35405624
17synaptic vesicle docking involved in exocytosis (GO:0016081)3.33188364
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.29956680
19regulation of glutamate receptor signaling pathway (GO:1900449)3.23538457
20neuron cell-cell adhesion (GO:0007158)3.22184341
21regulation of synaptic vesicle exocytosis (GO:2000300)3.17858802
22axonal fasciculation (GO:0007413)3.13759153
23vesicle transport along microtubule (GO:0047496)3.13596170
24cytoskeletal anchoring at plasma membrane (GO:0007016)3.11095199
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.10845357
26chaperone-mediated protein complex assembly (GO:0051131)3.09093903
27neuron recognition (GO:0008038)3.08311864
28embryonic retina morphogenesis in camera-type eye (GO:0060059)3.07557321
29protein targeting to Golgi (GO:0000042)3.07510573
30interkinetic nuclear migration (GO:0022027)3.06945051
31regulation of dendritic spine morphogenesis (GO:0061001)3.06646146
32dendrite morphogenesis (GO:0048813)3.05169829
33neuronal action potential propagation (GO:0019227)3.02693949
34protein localization to synapse (GO:0035418)3.02585807
35nucleus localization (GO:0051647)3.01812800
36establishment of protein localization to Golgi (GO:0072600)2.99246508
37regulation of long-term neuronal synaptic plasticity (GO:0048169)2.97662345
38regulation of neuronal synaptic plasticity (GO:0048168)2.95263790
39neurofilament cytoskeleton organization (GO:0060052)2.95248201
40SMAD protein complex assembly (GO:0007183)2.93946965
41glutamate receptor signaling pathway (GO:0007215)2.92253212
42establishment of nucleus localization (GO:0040023)2.91399623
43neurotransmitter secretion (GO:0007269)2.89033530
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.88706014
45activation of protein kinase A activity (GO:0034199)2.86404504
46negative regulation of neurotransmitter transport (GO:0051589)2.86294095
47central nervous system neuron axonogenesis (GO:0021955)2.86176327
48innervation (GO:0060384)2.86010001
49phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.83980858
50neuromuscular process controlling balance (GO:0050885)2.83843009
51retrograde transport, vesicle recycling within Golgi (GO:0000301)2.79921496
52cellular potassium ion homeostasis (GO:0030007)2.78421511
53regulation of pigment cell differentiation (GO:0050932)2.77317300
54neuron maturation (GO:0042551)2.75826342
55dendritic spine organization (GO:0097061)2.74990521
56transmission of nerve impulse (GO:0019226)2.74630801
57central nervous system myelination (GO:0022010)2.74246189
58axon ensheathment in central nervous system (GO:0032291)2.74246189
59regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.73854371
60nerve growth factor signaling pathway (GO:0038180)2.72599000
61apical protein localization (GO:0045176)2.72202053
62proline transport (GO:0015824)2.69481486
63regulation of female receptivity (GO:0045924)2.68609884
64regulation of establishment of cell polarity (GO:2000114)2.68403807
65Sertoli cell development (GO:0060009)2.65610490
66sodium ion export (GO:0071436)2.64913171
67gamma-aminobutyric acid signaling pathway (GO:0007214)2.62464110
68insulin-like growth factor receptor signaling pathway (GO:0048009)2.61454613
69synaptic transmission, glutamatergic (GO:0035249)2.60504967
70regulation of excitatory postsynaptic membrane potential (GO:0060079)2.60503438
71neuron-neuron synaptic transmission (GO:0007270)2.60454832
72regulation of dendritic spine development (GO:0060998)2.60261414
73regulation of axon extension involved in axon guidance (GO:0048841)2.60054011
74long-term synaptic potentiation (GO:0060291)2.59749011
75cell differentiation in hindbrain (GO:0021533)2.59131089
76regulation of synaptic vesicle transport (GO:1902803)2.57804512
77positive regulation of neurological system process (GO:0031646)2.57394791
78body morphogenesis (GO:0010171)2.57239548
79positive regulation of gastrulation (GO:2000543)2.56931881
80postsynaptic membrane organization (GO:0001941)2.56902220
81regulation of response to food (GO:0032095)2.56232221
82membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.56050816
83protein localization to Golgi apparatus (GO:0034067)2.55506080
84organelle transport along microtubule (GO:0072384)2.54843917
85suckling behavior (GO:0001967)2.54415574
86cerebellar Purkinje cell differentiation (GO:0021702)2.54060173
87presynaptic membrane assembly (GO:0097105)2.53414399
88negative regulation of dendrite morphogenesis (GO:0050774)2.53189034
89regulation of synaptic plasticity (GO:0048167)2.52577276
90regulation of axon guidance (GO:1902667)2.51394834
91receptor recycling (GO:0001881)2.50358535
92inner ear receptor cell development (GO:0060119)2.50116094
93regulation of postsynaptic membrane potential (GO:0060078)2.49807213
94negative regulation of organelle assembly (GO:1902116)2.49765400
95negative regulation of dendrite development (GO:2000171)2.49200209
96regulation of synaptic transmission, glutamatergic (GO:0051966)2.48700086
97auditory behavior (GO:0031223)2.48670111
98protein localization to endosome (GO:0036010)2.48223082
99G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.47549107
100positive regulation of fibroblast migration (GO:0010763)2.46939580
101histone H3-K4 trimethylation (GO:0080182)2.46655567
102embryonic body morphogenesis (GO:0010172)2.45284678
103urinary tract smooth muscle contraction (GO:0014848)2.45160825
104heart field specification (GO:0003128)2.44235198
105secondary heart field specification (GO:0003139)2.44235198
106regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.42423504
107neurotransmitter-gated ion channel clustering (GO:0072578)2.42032736
108clathrin coat assembly (GO:0048268)2.41661938
109bone trabecula formation (GO:0060346)2.38928638
110gamma-aminobutyric acid transport (GO:0015812)2.38560349
111neuronal ion channel clustering (GO:0045161)2.38455854
112axon extension (GO:0048675)2.38403004
113negative regulation of cytosolic calcium ion concentration (GO:0051481)2.37706026
114mating behavior (GO:0007617)2.36397160
115negative regulation of Ras GTPase activity (GO:0034261)2.35977025
116pyrimidine nucleobase catabolic process (GO:0006208)2.35899204
117regulation of protein glycosylation (GO:0060049)2.34954999
118regulation of clathrin-mediated endocytosis (GO:2000369)2.34418403
119synapse organization (GO:0050808)2.34269989
120L-amino acid import (GO:0043092)2.33001207
121regulation of action potential (GO:0098900)2.32205462
122positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.31860241
123heart valve formation (GO:0003188)2.29963045
124neuron remodeling (GO:0016322)2.29835670
125regulation of cAMP-dependent protein kinase activity (GO:2000479)2.29779833
126long-term memory (GO:0007616)2.28993362
127neuronal action potential (GO:0019228)2.28662240
128retina layer formation (GO:0010842)2.27892584
129neuron projection extension (GO:1990138)2.27010932
130neuromuscular process (GO:0050905)2.25447600
131asymmetric protein localization (GO:0008105)2.25164667
132synapse assembly (GO:0007416)2.24879665
133positive regulation of catecholamine secretion (GO:0033605)2.24299359
134dentate gyrus development (GO:0021542)2.24137994
135ephrin receptor signaling pathway (GO:0048013)2.23771080
136labyrinthine layer development (GO:0060711)2.23599249
137cerebral cortex radially oriented cell migration (GO:0021799)2.23456089
138myoblast fusion (GO:0007520)2.23410538
139regulation of ARF protein signal transduction (GO:0032012)2.22943670
140membrane depolarization during action potential (GO:0086010)2.22711279
141female mating behavior (GO:0060180)2.22271713
142regulation of establishment or maintenance of cell polarity (GO:0032878)2.21988842
143prostate gland growth (GO:0060736)2.21942522
144G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.21942395
145regulation of synapse structural plasticity (GO:0051823)2.21736073
146regulation of dopamine secretion (GO:0014059)2.21605745
147membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.21513277
148positive regulation of membrane potential (GO:0045838)2.21386783
149cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.20963523
150phospholipid translocation (GO:0045332)2.20506959
151lipid translocation (GO:0034204)2.20506959
152positive regulation of axon extension (GO:0045773)2.20390648
153adult walking behavior (GO:0007628)2.19966670
154negative regulation of sodium ion transport (GO:0010766)2.19175019
155neurotransmitter transport (GO:0006836)2.18481206
156detection of calcium ion (GO:0005513)2.18275830
157presynaptic membrane organization (GO:0097090)2.18223200
158membrane depolarization (GO:0051899)2.17600854
159negative regulation of neurotransmitter secretion (GO:0046929)2.17176304
160regulation of dendrite morphogenesis (GO:0048814)2.17157034
161negative regulation of vascular permeability (GO:0043116)2.14437769
162positive regulation of muscle hypertrophy (GO:0014742)2.14160289
163positive regulation of cardiac muscle hypertrophy (GO:0010613)2.14160289
164synaptic vesicle endocytosis (GO:0048488)2.13744479
165regulation of neurotransmitter secretion (GO:0046928)2.13717797
166cochlea development (GO:0090102)2.13643597

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.94606836
2GBX2_23144817_ChIP-Seq_PC3_Human3.25709101
3* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.53701465
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.39794253
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.28553516
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.20307732
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.20307732
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.19109629
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.12559431
10ZNF217_24962896_ChIP-Seq_MCF-7_Human2.04780142
11AR_21572438_ChIP-Seq_LNCaP_Human2.04335525
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03992183
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02861059
14DROSHA_22980978_ChIP-Seq_HELA_Human1.99276846
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96572425
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.92816081
17TP53_16413492_ChIP-PET_HCT116_Human1.92112491
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90926044
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.88703559
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.88400770
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.87923805
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82889266
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80602536
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80478933
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.76050592
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.70693156
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.70564826
28SMAD4_21799915_ChIP-Seq_A2780_Human1.68553675
29ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.68473082
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.67505813
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.64789370
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64332773
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.62974094
34* RARB_27405468_Chip-Seq_BRAIN_Mouse1.62009984
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61925811
36* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61064661
37ZNF274_21170338_ChIP-Seq_K562_Hela1.60481841
38AHR_22903824_ChIP-Seq_MCF-7_Human1.60012053
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59871515
40* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.59591497
41ARNT_22903824_ChIP-Seq_MCF-7_Human1.55907341
42TAF15_26573619_Chip-Seq_HEK293_Human1.55274550
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54263381
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51927724
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50124504
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47129856
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46475794
48* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46444111
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46439210
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.46301803
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45889563
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.44577152
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.42309075
54STAT3_23295773_ChIP-Seq_U87_Human1.42255238
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41504380
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.41085044
57* NANOG_18555785_Chip-Seq_ESCs_Mouse1.40480273
58SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40154763
59TP53_18474530_ChIP-ChIP_U2OS_Human1.39418829
60* SOX2_21211035_ChIP-Seq_LN229_Gbm1.36976320
61* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36966554
62REST_21632747_ChIP-Seq_MESCs_Mouse1.36566198
63RNF2_27304074_Chip-Seq_NSC_Mouse1.36522259
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36110802
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35928999
66IGF1R_20145208_ChIP-Seq_DFB_Human1.35841113
67ER_23166858_ChIP-Seq_MCF-7_Human1.35497644
68WT1_25993318_ChIP-Seq_PODOCYTE_Human1.34669175
69WT1_19549856_ChIP-ChIP_CCG9911_Human1.34646553
70P300_19829295_ChIP-Seq_ESCs_Human1.31318593
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30451255
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30451255
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28784003
74VDR_22108803_ChIP-Seq_LS180_Human1.28757012
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28387576
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27682339
77AR_25329375_ChIP-Seq_VCAP_Human1.26623983
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26475352
79BCAT_22108803_ChIP-Seq_LS180_Human1.25180092
80TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25134533
81* E2F1_18555785_Chip-Seq_ESCs_Mouse1.23977797
82* AR_19668381_ChIP-Seq_PC3_Human1.22598157
83ESR1_20079471_ChIP-ChIP_T-47D_Human1.21221737
84* P53_22387025_ChIP-Seq_ESCs_Mouse1.21213856
85CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20989984
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20006179
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20006179
88* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18640417
89EWS_26573619_Chip-Seq_HEK293_Human1.18000826
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17957227
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17404617
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.16650417
93TCF4_23295773_ChIP-Seq_U87_Human1.16412071
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16101280
95ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15564846
96* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14846849
97CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14302933
98LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12690415
99FUS_26573619_Chip-Seq_HEK293_Human1.12629719
100* CMYC_18555785_Chip-Seq_ESCs_Mouse1.11416614
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08978453
102RXR_22108803_ChIP-Seq_LS180_Human1.07990717
103KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07976634
104PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06845352
105RUNX2_22187159_ChIP-Seq_PCA_Human1.03375136
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03369748
107SMAD3_21741376_ChIP-Seq_HESCs_Human1.00566188
108RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00464023
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00427035
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00186849
111STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99643681
112RING1B_27294783_Chip-Seq_NPCs_Mouse0.99314579
113ESR2_21235772_ChIP-Seq_MCF-7_Human0.98643024
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98213886
115* PRDM14_20953172_ChIP-Seq_ESCs_Human0.97050407
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96844473
117SMAD4_21741376_ChIP-Seq_HESCs_Human0.96254392
118CJUN_26792858_Chip-Seq_BT549_Human0.94861820
119* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94456935
120* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93660405
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92974920
122SMAD3_21741376_ChIP-Seq_ESCs_Human0.92498092
123FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92144837
124RING1B_27294783_Chip-Seq_ESCs_Mouse0.92119991
125TCF4_22108803_ChIP-Seq_LS180_Human0.91885367

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.91629097
2MP0003635_abnormal_synaptic_transmissio3.10104844
3MP0008438_abnormal_cutaneous_collagen3.05547082
4MP0004270_analgesia2.97541228
5MP0005623_abnormal_meninges_morphology2.94893027
6MP0010234_abnormal_vibrissa_follicle2.94101558
7MP0003880_abnormal_central_pattern2.91026496
8MP0009780_abnormal_chondrocyte_physiolo2.84182509
9MP0003890_abnormal_embryonic-extraembry2.58360455
10MP0009745_abnormal_behavioral_response2.46032929
11MP0009379_abnormal_foot_pigmentation2.38489827
12MP0002063_abnormal_learning/memory/cond2.35145996
13MP0001968_abnormal_touch/_nociception2.33047209
14MP0002064_seizures2.13767313
15MP0000427_abnormal_hair_cycle2.12133334
16MP0008877_abnormal_DNA_methylation2.07314084
17MP0009046_muscle_twitch2.07148372
18MP0004272_abnormal_basement_membrane2.05249245
19MP0005275_abnormal_skin_tensile2.01170895
20MP0009384_cardiac_valve_regurgitation2.00754900
21MP0002735_abnormal_chemical_nociception1.93414755
22MP0002822_catalepsy1.90195525
23MP0002572_abnormal_emotion/affect_behav1.85034556
24MP0002736_abnormal_nociception_after1.83109964
25MP0001299_abnormal_eye_distance/1.79437233
26MP0003045_fibrosis1.78753777
27MP0004142_abnormal_muscle_tone1.77294160
28MP0002638_abnormal_pupillary_reflex1.76551165
29MP0000569_abnormal_digit_pigmentation1.76208648
30MP0003123_paternal_imprinting1.74476467
31MP0001486_abnormal_startle_reflex1.72959870
32MP0005503_abnormal_tendon_morphology1.72779126
33MP0002734_abnormal_mechanical_nocicepti1.67553429
34MP0004858_abnormal_nervous_system1.65197212
35MP0008057_abnormal_DNA_replication1.64762609
36MP0003787_abnormal_imprinting1.63890903
37MP0003329_amyloid_beta_deposits1.62125074
38MP0000013_abnormal_adipose_tissue1.61188616
39MP0002272_abnormal_nervous_system1.58175807
40MP0000537_abnormal_urethra_morphology1.56816909
41MP0003705_abnormal_hypodermis_morpholog1.55736007
42MP0003300_gastrointestinal_ulcer1.52735186
43MP0000383_abnormal_hair_follicle1.45227957
44MP0003868_abnormal_feces_composition1.41713569
45MP0005409_darkened_coat_color1.39653168
46MP0005171_absent_coat_pigmentation1.37295444
47MP0001440_abnormal_grooming_behavior1.35625170
48MP0003122_maternal_imprinting1.35106516
49MP0002067_abnormal_sensory_capabilities1.34112105
50MP0008569_lethality_at_weaning1.33463015
51MP0002733_abnormal_thermal_nociception1.33338301
52MP0002876_abnormal_thyroid_physiology1.31058443
53MP0000778_abnormal_nervous_system1.30903045
54MP0001501_abnormal_sleep_pattern1.26603817
55MP0000534_abnormal_ureter_morphology1.26357082
56MP0002184_abnormal_innervation1.25181428
57MP0003385_abnormal_body_wall1.24247370
58MP0003091_abnormal_cell_migration1.22981514
59MP0002160_abnormal_reproductive_system1.21390689
60MP0001970_abnormal_pain_threshold1.20350606
61MP0004811_abnormal_neuron_physiology1.19803925
62MP0002896_abnormal_bone_mineralization1.19746251
63MP0001485_abnormal_pinna_reflex1.19167169
64MP0002909_abnormal_adrenal_gland1.18104680
65MP0000920_abnormal_myelination1.16432054
66MP0001958_emphysema1.15531736
67MP0004130_abnormal_muscle_cell1.14971580
68MP0002557_abnormal_social/conspecific_i1.14859521
69* MP0001177_atelectasis1.13083737
70MP0005646_abnormal_pituitary_gland1.10907288
71MP0003283_abnormal_digestive_organ1.09439618
72MP0000955_abnormal_spinal_cord1.06776770
73MP0002009_preneoplasia1.06387146
74MP0004742_abnormal_vestibular_system1.06354171
75MP0003690_abnormal_glial_cell1.05587815
76MP0004145_abnormal_muscle_electrophysio1.03999744
77MP0003633_abnormal_nervous_system1.03003981
78MP0005174_abnormal_tail_pigmentation1.02969658
79MP0000462_abnormal_digestive_system1.01667372
80MP0006054_spinal_hemorrhage1.01353406
81MP0004885_abnormal_endolymph1.00700758
82MP0010386_abnormal_urinary_bladder1.00448274
83MP0010678_abnormal_skin_adnexa1.00037712
84MP0000566_synostosis0.97278634
85MP0002877_abnormal_melanocyte_morpholog0.95584984
86MP0005187_abnormal_penis_morphology0.94980691
87MP0002882_abnormal_neuron_morphology0.94687605
88MP0005386_behavior/neurological_phenoty0.93501419
89MP0004924_abnormal_behavior0.93501419
90MP0005408_hypopigmentation0.93214544
91MP0000538_abnormal_urinary_bladder0.93120631
92MP0000631_abnormal_neuroendocrine_gland0.92060421
93MP0003634_abnormal_glial_cell0.91460583
94MP0005389_reproductive_system_phenotype0.90810304
95MP0003631_nervous_system_phenotype0.89101054
96MP0001984_abnormal_olfaction0.88892915
97MP0002066_abnormal_motor_capabilities/c0.88217103
98MP0000604_amyloidosis0.86186010
99MP0003632_abnormal_nervous_system0.85601863
100MP0009250_abnormal_appendicular_skeleto0.85429967
101MP0001188_hyperpigmentation0.85352629
102MP0000015_abnormal_ear_pigmentation0.85111751
103MP0002163_abnormal_gland_morphology0.84777317
104MP0003950_abnormal_plasma_membrane0.84230953
105MP0002090_abnormal_vision0.81133596
106MP0002152_abnormal_brain_morphology0.80819670
107MP0001919_abnormal_reproductive_system0.80473359
108MP0000428_abnormal_craniofacial_morphol0.80170508
109MP0002752_abnormal_somatic_nervous0.79887526
110MP0005195_abnormal_posterior_eye0.79673003
111MP0004484_altered_response_of0.79547326
112MP0003937_abnormal_limbs/digits/tail_de0.79529002
113MP0002108_abnormal_muscle_morphology0.79105643
114MP0001944_abnormal_pancreas_morphology0.78669339
115MP0001756_abnormal_urination0.78269708
116MP0003861_abnormal_nervous_system0.77893621
117MP0003879_abnormal_hair_cell0.77242904
118MP0001879_abnormal_lymphatic_vessel0.76497530
119MP0003936_abnormal_reproductive_system0.73707205
120MP0003942_abnormal_urinary_system0.73535395
121MP0001286_abnormal_eye_development0.71711287
122MP0003121_genomic_imprinting0.71627884
123MP0003279_aneurysm0.71031880
124MP0005551_abnormal_eye_electrophysiolog0.70431635
125MP0004085_abnormal_heartbeat0.69750396
126MP0002177_abnormal_outer_ear0.69395437
127MP0002653_abnormal_ependyma_morphology0.68702623
128MP0002095_abnormal_skin_pigmentation0.68169753
129MP0009053_abnormal_anal_canal0.68080099
130MP0005423_abnormal_somatic_nervous0.67370275
131* MP0002295_abnormal_pulmonary_circulatio0.66647791
132MP0004134_abnormal_chest_morphology0.65519428
133MP0000003_abnormal_adipose_tissue0.64437846
134MP0002168_other_aberrant_phenotype0.64194049
135MP0006276_abnormal_autonomic_nervous0.63307873
136MP0000747_muscle_weakness0.63201002
137MP0001664_abnormal_digestion0.62675067
138MP0004233_abnormal_muscle_weight0.62553621
139MP0004185_abnormal_adipocyte_glucose0.62411276
140MP0005257_abnormal_intraocular_pressure0.61683969
141* MP0003115_abnormal_respiratory_system0.61611653
142MP0005076_abnormal_cell_differentiation0.61205746

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.30640571
2Atonic seizures (HP:0010819)3.61054598
3Curly hair (HP:0002212)3.58581607
4Termporal pattern (HP:0011008)3.51848630
5Insidious onset (HP:0003587)3.51848630
6Focal seizures (HP:0007359)3.50734376
7Papillary thyroid carcinoma (HP:0002895)3.46898091
8Arterial tortuosity (HP:0005116)3.28059016
9Hyperventilation (HP:0002883)3.26254317
10Vascular tortuosity (HP:0004948)3.25495851
11Cerebral aneurysm (HP:0004944)3.25256715
12Volvulus (HP:0002580)3.20439172
13Action tremor (HP:0002345)3.19338419
14Myokymia (HP:0002411)3.07890773
15Aortic aneurysm (HP:0004942)3.04035622
16Deep palmar crease (HP:0006191)3.01445290
17Short chin (HP:0000331)3.01197875
18Abnormal pancreas size (HP:0012094)2.95314377
19Premature rupture of membranes (HP:0001788)2.90577822
20Buphthalmos (HP:0000557)2.85126798
21Vertebral arch anomaly (HP:0008438)2.78862326
22Aortic dissection (HP:0002647)2.74297169
23Shallow orbits (HP:0000586)2.72991256
24Papilledema (HP:0001085)2.72262373
25Concave nail (HP:0001598)2.71887740
26Shawl scrotum (HP:0000049)2.65243673
27Protrusio acetabuli (HP:0003179)2.56362849
28Large earlobe (HP:0009748)2.54027200
29Progressive cerebellar ataxia (HP:0002073)2.46330219
30Epileptic encephalopathy (HP:0200134)2.42153784
31Mitral valve prolapse (HP:0001634)2.40149265
32Protruding tongue (HP:0010808)2.37154994
33Visual hallucinations (HP:0002367)2.36140946
34Scanning speech (HP:0002168)2.35859794
35Bladder neoplasm (HP:0009725)2.32903870
36Bladder carcinoma (HP:0002862)2.32903870
37Absence seizures (HP:0002121)2.32732671
38Macroorchidism (HP:0000053)2.31214869
39Febrile seizures (HP:0002373)2.30245445
40Ankyloglossia (HP:0010296)2.28855888
41Cerebral inclusion bodies (HP:0100314)2.25946786
42Urinary bladder sphincter dysfunction (HP:0002839)2.25267309
43Thyroid carcinoma (HP:0002890)2.23067633
44Aqueductal stenosis (HP:0002410)2.22759568
45Impaired vibration sensation in the lower limbs (HP:0002166)2.22030187
46Dilatation of the ascending aorta (HP:0005111)2.21989187
47Truncal ataxia (HP:0002078)2.20214019
48Abnormality of oral frenula (HP:0000190)2.19557683
49Excessive salivation (HP:0003781)2.18797719
50Drooling (HP:0002307)2.18797719
51Dysmetric saccades (HP:0000641)2.18374177
52Truncal obesity (HP:0001956)2.17492781
53Atrophic scars (HP:0001075)2.15788540
54Overgrowth (HP:0001548)2.11666267
55Renovascular hypertension (HP:0100817)2.10441950
56Absent frontal sinuses (HP:0002688)2.09499174
57Lower limb amyotrophy (HP:0007210)2.06181481
58Agitation (HP:0000713)2.05839480
59Hip dysplasia (HP:0001385)2.05487385
60Gaze-evoked nystagmus (HP:0000640)2.05440171
61Obstructive sleep apnea (HP:0002870)2.04460481
62Rhabdomyosarcoma (HP:0002859)2.03044754
63Inappropriate behavior (HP:0000719)2.02716927
64Genetic anticipation (HP:0003743)2.02560591
65Dialeptic seizures (HP:0011146)2.02558750
66Barrel-shaped chest (HP:0001552)2.02306249
67Urinary urgency (HP:0000012)2.02131886
68Pulmonic stenosis (HP:0001642)2.01689308
69Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01299036
70Degeneration of the lateral corticospinal tracts (HP:0002314)2.01299036
71Generalized tonic-clonic seizures (HP:0002069)2.00206611
72Aneurysm (HP:0002617)1.99394500
73Exotropia (HP:0000577)1.98807613
74Nephronophthisis (HP:0000090)1.98341184
75Bowel diverticulosis (HP:0005222)1.96774562
76Abnormality of the corticospinal tract (HP:0002492)1.95253568
77Sleep apnea (HP:0010535)1.95240236
78Asymmetry of the thorax (HP:0001555)1.95225540
79Lower limb asymmetry (HP:0100559)1.92785448
80Impaired vibratory sensation (HP:0002495)1.91811269
81Bladder diverticulum (HP:0000015)1.91548750
82Ankle clonus (HP:0011448)1.91491218
83Oligodactyly (hands) (HP:0001180)1.89621648
84Heterotopia (HP:0002282)1.88054336
85Rib fusion (HP:0000902)1.87835095
86Fetal akinesia sequence (HP:0001989)1.86804852
87Hypophosphatemic rickets (HP:0004912)1.85506358
88Amblyopia (HP:0000646)1.85179277
89Fair hair (HP:0002286)1.84956453
90Dysmetria (HP:0001310)1.84921617
91Genu recurvatum (HP:0002816)1.84298945
92Abnormality of salivation (HP:0100755)1.84035438
93Widely spaced teeth (HP:0000687)1.82253610
94Intention tremor (HP:0002080)1.82103236
95Striae distensae (HP:0001065)1.81975271
96Abnormality of the ischium (HP:0003174)1.80860546
97Broad ribs (HP:0000885)1.80156997
98Spastic gait (HP:0002064)1.79574470
99Resting tremor (HP:0002322)1.79014502
100Broad-based gait (HP:0002136)1.78853714
101Spondylolisthesis (HP:0003302)1.78762635
102Relative macrocephaly (HP:0004482)1.78614316
103Broad metatarsal (HP:0001783)1.77847074
104Hepatoblastoma (HP:0002884)1.77664123
105Supranuclear gaze palsy (HP:0000605)1.76961384
106Mutism (HP:0002300)1.76762832
107Chronic hepatic failure (HP:0100626)1.76548358
108Absent speech (HP:0001344)1.75763411
109Hematochezia (HP:0002573)1.74682720
110Focal segmental glomerulosclerosis (HP:0000097)1.74450318
111Woolly hair (HP:0002224)1.72448010
112Epileptiform EEG discharges (HP:0011182)1.71505459
113Bronchomalacia (HP:0002780)1.71450974
114Neurofibrillary tangles (HP:0002185)1.70374690
115Hyperextensible skin (HP:0000974)1.70048779
116Abnormality of the renal medulla (HP:0100957)1.69321038
117Ulnar claw (HP:0001178)1.69177463
118Oligodontia (HP:0000677)1.67257575
119Depression (HP:0000716)1.67228230
120Menstrual irregularities (HP:0000858)1.66961234
121Hammertoe (HP:0001765)1.66288980
122Narrow forehead (HP:0000341)1.66080714
123Impaired social interactions (HP:0000735)1.66032417
124Abnormal social behavior (HP:0012433)1.66032417
125Abnormality of abdominal situs (HP:0011620)1.65090751
126Abdominal situs inversus (HP:0003363)1.65090751
127Congenital glaucoma (HP:0001087)1.64906034
128Abnormality of the diencephalon (HP:0010662)1.64316400
129Neonatal hypoglycemia (HP:0001998)1.63812061
130Fragile skin (HP:0001030)1.63550594
131Abnormal number of incisors (HP:0011064)1.63311799
132Postural instability (HP:0002172)1.63103657
133Scapular winging (HP:0003691)1.62917084
134Flat cornea (HP:0007720)1.62587981
135Megalencephaly (HP:0001355)1.62418543
136Transitional cell carcinoma of the bladder (HP:0006740)1.62284179
137Increased number of teeth (HP:0011069)1.62217536
138Medial flaring of the eyebrow (HP:0010747)1.61019091
139Stereotypic behavior (HP:0000733)1.60430159
140Dysdiadochokinesis (HP:0002075)1.59864015
141Hypoplastic labia majora (HP:0000059)1.59362420
142Pointed chin (HP:0000307)1.59326594
143Subacute progressive viral hepatitis (HP:0006572)1.59298897
144Abnormality of the frontal sinuses (HP:0002687)1.59173234
145Highly arched eyebrow (HP:0002553)1.58744225
146Round face (HP:0000311)1.58649598
147Pancreatic fibrosis (HP:0100732)1.58119895
148Sudden death (HP:0001699)1.57959471
149Sacral dimple (HP:0000960)1.57926327
150Exostoses (HP:0100777)1.57739297
151Metaphyseal dysplasia (HP:0100255)1.57612508
152Apathy (HP:0000741)1.57379447
153Hemiplegia (HP:0002301)1.57322649
154Abnormality of the incisor (HP:0000676)1.55381206
155Morphological abnormality of the pyramidal tract (HP:0002062)1.55156740
156Urethral obstruction (HP:0000796)1.55064127
157Wormian bones (HP:0002645)1.54945892
158Hypoplasia of the iris (HP:0007676)1.54916165
159Tracheomalacia (HP:0002779)1.54122881
160Enlarged penis (HP:0000040)1.54043946
161Lower limb muscle weakness (HP:0007340)1.53986829
162Distal lower limb amyotrophy (HP:0008944)1.52987050
163Limb hypertonia (HP:0002509)1.52943730
164Soft skin (HP:0000977)1.52511905
165Type II lissencephaly (HP:0007260)1.52264597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.28430893
2EPHA43.55086794
3MAP3K92.62717724
4NTRK12.62615271
5FRK2.52508561
6MAP3K42.51678601
7MINK12.13061936
8MAP3K22.07668541
9FER1.85158499
10SCYL21.82426882
11KSR21.82208439
12FGFR21.81922837
13PLK21.75011873
14PDGFRA1.72909776
15DDR21.67038286
16STK391.63663457
17CAMK1G1.59875160
18CAMKK11.53131667
19TYRO31.49866558
20STK38L1.48358501
21PRKD31.46466920
22PNCK1.45998919
23RIPK41.42370229
24PAK61.39623005
25RET1.36286046
26WNK31.35011349
27LATS11.32924364
28PAK31.32706540
29MAP2K41.31389020
30PIK3CA1.27640339
31PINK11.25860240
32CASK1.24995353
33WNK11.22740224
34DAPK21.22259034
35BMPR1B1.19999258
36MAPK131.16483229
37PKN21.15753448
38MARK11.15221255
39CDK51.14313533
40PDGFRB1.13792972
41DMPK1.10802972
42MAP2K71.08156943
43WNK41.06498948
44FES1.06374601
45PRKCH1.02222674
46LATS20.98493543
47CAMKK20.98212622
48OXSR10.98080246
49KSR10.98027842
50PTK2B0.96583903
51TNIK0.94080747
52ALK0.90927504
53BMPR20.89827020
54EPHB20.89379158
55STK380.89306207
56MAP3K120.88648509
57SIK20.88280152
58MAP2K10.86072804
59TRPM70.84044610
60NTRK20.82943271
61CAMK1D0.82234145
62PTK20.81844009
63CSNK1E0.81442434
64CAMK10.81104062
65RIPK10.80783555
66FGR0.79996898
67LMTK20.77825938
68DYRK1A0.77023131
69PDK10.75965307
70CAMK2A0.75800084
71PRKCZ0.74886855
72PAK20.74402744
73SGK10.73848338
74CSNK1G20.72391610
75MST1R0.72215275
76PDPK10.71909117
77TGFBR20.71442951
78CAMK2B0.71123420
79MAP3K60.68476343
80IRAK20.67152118
81FGFR10.67001247
82MAPK150.65972667
83PRKCE0.65898871
84ROCK20.63978870
85ROCK10.63025593
86CDK140.62991604
87PIK3CG0.62925364
88ERBB30.62913253
89PRKCG0.62784862
90TRIB30.62606988
91AKT30.62019270
92STK110.61334254
93SGK2230.60876339
94SGK4940.60876339
95MET0.59974767
96PTK60.59762016
97MYLK0.59151710
98MARK20.59130512
99FYN0.58932477
100SGK30.58139855
101MAP3K70.57000257
102GRK50.55119997
103PRKG10.54980150
104CDK150.54381840
105TNK20.54116235
106SGK20.54025292
107GRK10.52494095
108CDK180.52315313
109ADRBK10.51575593
110INSR0.50895560
111DYRK1B0.50126493
112RPS6KB10.49399950
113TTN0.49229361
114TEC0.49203031
115ERBB20.49197252
116MATK0.49186413
117CDC42BPA0.49127946
118STK30.47997625
119MAPK100.47353697
120BRD40.46528648
121NEK60.46486335
122MTOR0.45463268
123RPS6KA30.44601309
124SRC0.44582158
125DAPK10.44575554
126TAOK30.44145542
127ILK0.44063768
128SIK10.43081992
129STK240.42626151
130CSNK1A1L0.42385580
131FGFR30.41558650
132CSNK1D0.41380328
133UHMK10.41107934
134RAF10.40571308
135CAMK2D0.40567538
136PRKACA0.40404240
137MKNK20.39679489

Predicted pathways (KEGG)

RankGene SetZ-score
1Long-term potentiation_Homo sapiens_hsa047202.32540766
2Nicotine addiction_Homo sapiens_hsa050332.23788303
3Circadian entrainment_Homo sapiens_hsa047131.93542252
4Amphetamine addiction_Homo sapiens_hsa050311.92084172
5Glutamatergic synapse_Homo sapiens_hsa047241.89470644
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.84470784
7Salivary secretion_Homo sapiens_hsa049701.84061471
8Synaptic vesicle cycle_Homo sapiens_hsa047211.83397328
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82156878
10GABAergic synapse_Homo sapiens_hsa047271.69800314
11Dopaminergic synapse_Homo sapiens_hsa047281.69612935
12Renin secretion_Homo sapiens_hsa049241.64377952
13Olfactory transduction_Homo sapiens_hsa047401.59554345
14Gastric acid secretion_Homo sapiens_hsa049711.58909984
15Cholinergic synapse_Homo sapiens_hsa047251.58743009
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57545644
17Morphine addiction_Homo sapiens_hsa050321.56795445
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.56500805
19Glioma_Homo sapiens_hsa052141.54580892
20Insulin secretion_Homo sapiens_hsa049111.48660624
21Axon guidance_Homo sapiens_hsa043601.47695011
22Long-term depression_Homo sapiens_hsa047301.46823278
23Oxytocin signaling pathway_Homo sapiens_hsa049211.46787863
24Estrogen signaling pathway_Homo sapiens_hsa049151.40960414
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38195711
26GnRH signaling pathway_Homo sapiens_hsa049121.35107329
27Gap junction_Homo sapiens_hsa045401.28866672
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28783879
29Cocaine addiction_Homo sapiens_hsa050301.28051045
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22874672
31Type II diabetes mellitus_Homo sapiens_hsa049301.21132419
32Dorso-ventral axis formation_Homo sapiens_hsa043201.19885635
33ECM-receptor interaction_Homo sapiens_hsa045121.18289492
34Prolactin signaling pathway_Homo sapiens_hsa049171.16335897
35Serotonergic synapse_Homo sapiens_hsa047261.13649849
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12978331
37ErbB signaling pathway_Homo sapiens_hsa040121.12787997
38Calcium signaling pathway_Homo sapiens_hsa040201.12512779
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11756777
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11573099
41cAMP signaling pathway_Homo sapiens_hsa040241.11246243
42Focal adhesion_Homo sapiens_hsa045101.10867314
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09264160
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08747691
45Melanogenesis_Homo sapiens_hsa049161.07815469
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.07074452
47Thyroid hormone synthesis_Homo sapiens_hsa049181.06647854
48Taste transduction_Homo sapiens_hsa047421.04408198
49Vascular smooth muscle contraction_Homo sapiens_hsa042701.01846212
50Phospholipase D signaling pathway_Homo sapiens_hsa040721.01784672
51Dilated cardiomyopathy_Homo sapiens_hsa054140.98999923
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94815103
53Alcoholism_Homo sapiens_hsa050340.94720712
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.92298417
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91392108
56Adherens junction_Homo sapiens_hsa045200.90899813
57Endometrial cancer_Homo sapiens_hsa052130.90880240
58Proteoglycans in cancer_Homo sapiens_hsa052050.89524381
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88762444
60Renal cell carcinoma_Homo sapiens_hsa052110.88717375
61Vibrio cholerae infection_Homo sapiens_hsa051100.88489260
62Pancreatic secretion_Homo sapiens_hsa049720.88243710
63Rap1 signaling pathway_Homo sapiens_hsa040150.87323066
64Platelet activation_Homo sapiens_hsa046110.86228268
65Ovarian steroidogenesis_Homo sapiens_hsa049130.85308823
66Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82576121
67Amoebiasis_Homo sapiens_hsa051460.82258822
68Choline metabolism in cancer_Homo sapiens_hsa052310.81473273
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80891197
70Fatty acid biosynthesis_Homo sapiens_hsa000610.79361752
71mTOR signaling pathway_Homo sapiens_hsa041500.79218384
72Tight junction_Homo sapiens_hsa045300.78954274
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.78466098
74VEGF signaling pathway_Homo sapiens_hsa043700.78272811
75Non-small cell lung cancer_Homo sapiens_hsa052230.77721579
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77237332
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76786711
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76567934
79FoxO signaling pathway_Homo sapiens_hsa040680.76463903
80Cardiac muscle contraction_Homo sapiens_hsa042600.75337564
81Thyroid cancer_Homo sapiens_hsa052160.74380161
82Hedgehog signaling pathway_Homo sapiens_hsa043400.73834450
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73801148
84Protein digestion and absorption_Homo sapiens_hsa049740.73579691
85Pancreatic cancer_Homo sapiens_hsa052120.71926491
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71411916
87Collecting duct acid secretion_Homo sapiens_hsa049660.70999776
88Nitrogen metabolism_Homo sapiens_hsa009100.70998557
89Oocyte meiosis_Homo sapiens_hsa041140.70997172
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70769028
91MAPK signaling pathway_Homo sapiens_hsa040100.70530029
92Butanoate metabolism_Homo sapiens_hsa006500.70411345
93Ras signaling pathway_Homo sapiens_hsa040140.69381824
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68498896
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68492083
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68279434
97Endocytosis_Homo sapiens_hsa041440.67466670
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67356899
99Wnt signaling pathway_Homo sapiens_hsa043100.67089453
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67010686
101Linoleic acid metabolism_Homo sapiens_hsa005910.66407263
102Colorectal cancer_Homo sapiens_hsa052100.65039174
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64346067
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.64224269
105Inositol phosphate metabolism_Homo sapiens_hsa005620.62960559
106Chronic myeloid leukemia_Homo sapiens_hsa052200.62823074
107Hippo signaling pathway_Homo sapiens_hsa043900.62511752
108Glucagon signaling pathway_Homo sapiens_hsa049220.61609974
109Melanoma_Homo sapiens_hsa052180.61554838
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61109223
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61081622
112Prostate cancer_Homo sapiens_hsa052150.59361897
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58245142
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57536873
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57427311
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.56720902
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55787638
118Vitamin B6 metabolism_Homo sapiens_hsa007500.54382266
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54156594
120Prion diseases_Homo sapiens_hsa050200.52971172
121Bile secretion_Homo sapiens_hsa049760.52789328

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