ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	9.84460694
2	lipopolysaccharide biosynthetic process (GO:0009103)	9.52159099
3	DNA methylation involved in gamete generation (GO:0043046)	8.99998396
4	protein-chromophore linkage (GO:0018298)	8.96395118
5	lipopolysaccharide metabolic process (GO:0008653)	8.37902348
6	regulation of meiosis I (GO:0060631)	8.33536501
7	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	7.65558999
8	paraxial mesoderm development (GO:0048339)	7.57444793
9	regulation of protein glycosylation (GO:0060049)	7.49896210
10	negative regulation of glycoprotein biosynthetic process (GO:0010561)	7.46953884
11	sulfate transmembrane transport (GO:1902358)	7.42173287
12	regulation of pigment cell differentiation (GO:0050932)	7.24935992
13	positive regulation of developmental pigmentation (GO:0048087)	7.03522342
14	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	6.92668525
15	negative regulation of cell cycle G2/M phase transition (GO:1902750)	6.81766654
16	piRNA metabolic process (GO:0034587)	6.29138253
17	sulfate transport (GO:0008272)	6.28461695
18	L-phenylalanine catabolic process (GO:0006559)	5.95343405
19	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.95343405
20	SMAD protein complex assembly (GO:0007183)	5.69521461
21	notochord development (GO:0030903)	5.69490373
22	negative regulation of glycoprotein metabolic process (GO:1903019)	5.56351585
23	tyrosine metabolic process (GO:0006570)	5.26931153
24	heme transport (GO:0015886)	5.26155522
25	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	5.08717914
26	L-phenylalanine metabolic process (GO:0006558)	5.08717914
27	ribonucleoprotein complex disassembly (GO:0032988)	5.02469998
28	positive regulation of meiosis (GO:0045836)	4.99606487
29	gamma-aminobutyric acid signaling pathway (GO:0007214)	4.89738001
30	positive regulation of meiotic cell cycle (GO:0051446)	4.63231231
31	nodal signaling pathway (GO:0038092)	4.60215514
32	centriole replication (GO:0007099)	4.53570950
33	negative regulation of stem cell proliferation (GO:2000647)	4.49826697
34	regulation of odontogenesis (GO:0042481)	4.40952026
35	serotonin receptor signaling pathway (GO:0007210)	4.39199360
36	regulation of transforming growth factor beta2 production (GO:0032909)	4.35826271
37	DNA damage induced protein phosphorylation (GO:0006975)	4.27251891
38	meiotic chromosome segregation (GO:0045132)	4.26199213
39	glycerol metabolic process (GO:0006071)	4.25366790
40	regulation of interleukin-5 production (GO:0032674)	4.20759652
41	response to mercury ion (GO:0046689)	4.17743379
42	regulation of rhodopsin mediated signaling pathway (GO:0022400)	4.15827237
43	regulation of nuclear cell cycle DNA replication (GO:0033262)	4.07678280
44	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	4.03551958
45	germinal center formation (GO:0002467)	4.01276952
46	protein retention in ER lumen (GO:0006621)	4.00570082
47	organelle disassembly (GO:1903008)	3.95823125
48	tachykinin receptor signaling pathway (GO:0007217)	3.95819250
49	cellular response to gamma radiation (GO:0071480)	3.92535990
50	vitamin transmembrane transport (GO:0035461)	3.92350437
51	iron coordination entity transport (GO:1901678)	3.82704498
52	rhodopsin mediated signaling pathway (GO:0016056)	3.77138596
53	response to epinephrine (GO:0071871)	3.76801778
54	positive regulation of SMAD protein import into nucleus (GO:0060391)	3.76643214
55	alditol metabolic process (GO:0019400)	3.74923826
56	regulation of nephron tubule epithelial cell differentiation (GO:0072182)	3.68429108
57	flavonoid metabolic process (GO:0009812)	3.63109930
58	aromatic amino acid family catabolic process (GO:0009074)	3.59634863
59	heart valve formation (GO:0003188)	3.58714934
60	toxin metabolic process (GO:0009404)	3.51678146
61	sulfur compound transport (GO:0072348)	3.51537723
62	regulation of developmental pigmentation (GO:0048070)	3.51136889
63	negative regulation of cell-matrix adhesion (GO:0001953)	3.47607987
64	pantothenate metabolic process (GO:0015939)	3.47277909
65	negative regulation of neural precursor cell proliferation (GO:2000178)	3.43609383
66	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.41062204
67	embryonic process involved in female pregnancy (GO:0060136)	3.38078257
68	sympathetic nervous system development (GO:0048485)	3.36754898
69	lysine catabolic process (GO:0006554)	3.35040177
70	lysine metabolic process (GO:0006553)	3.35040177
71	biotin metabolic process (GO:0006768)	3.33298963
72	inflammatory response to antigenic stimulus (GO:0002437)	3.32977605
73	uterus development (GO:0060065)	3.32735972
74	aspartate family amino acid catabolic process (GO:0009068)	3.32040945
75	regulation of epithelial cell differentiation involved in kidney development (GO:2000696)	3.22315354
76	organ induction (GO:0001759)	3.19639626
77	regulation of keratinocyte proliferation (GO:0010837)	3.18971299
78	protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)	3.18354496
79	somite rostral/caudal axis specification (GO:0032525)	3.16108437
80	DNA alkylation (GO:0006305)	3.15985499
81	DNA methylation (GO:0006306)	3.15985499
82	urate metabolic process (GO:0046415)	3.09330054
83	polyol biosynthetic process (GO:0046173)	3.08197639
84	regulation of translational termination (GO:0006449)	3.04680677
85	aromatic amino acid family metabolic process (GO:0009072)	3.02081738
86	regulation of hair follicle development (GO:0051797)	3.01587921
87	centriole assembly (GO:0098534)	2.97617644
88	regulation of SMAD protein import into nucleus (GO:0060390)	2.94203523
89	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.88540516
90	negative regulation of BMP signaling pathway (GO:0030514)	2.88163449
91	membrane lipid biosynthetic process (GO:0046467)	2.83115526
92	sphingolipid biosynthetic process (GO:0030148)	2.81108048
93	positive regulation of vascular permeability (GO:0043117)	2.80139835
94	positive regulation of fatty acid oxidation (GO:0046321)	2.78320573
95	regulation of metanephros development (GO:0072215)	2.76687534
96	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.71446165
97	oogenesis (GO:0048477)	2.70081305
98	sphingosine metabolic process (GO:0006670)	17.3967456
99	diol metabolic process (GO:0034311)	15.7390961
100	sphingoid metabolic process (GO:0046519)	14.0222433

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	AR_21572438_ChIP-Seq_LNCaP_Human	5.42408576
2	IGF1R_20145208_ChIP-Seq_DFB_Human	5.19740868
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.64127743
4	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.42492601
5	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	3.19590978
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.87479201
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.73732553
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.62307571
9	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.48430123
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.27394401
11	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.18683865
12	P300_19829295_ChIP-Seq_ESCs_Human	2.09454562
13	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	2.09272675
14	EGR1_19032775_ChIP-ChIP_M12_Human	2.07780963
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.06649422
16	ZNF274_21170338_ChIP-Seq_K562_Hela	1.87635949
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.85066183
18	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.80047944
19	SOX2_19829295_ChIP-Seq_ESCs_Human	1.78563097
20	NANOG_19829295_ChIP-Seq_ESCs_Human	1.78563097
21	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.77202596
22	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.77202596
23	HOXB7_26014856_ChIP-Seq_BT474_Human	1.74513809
24	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.71863002
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.70514119
26	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.69603528
27	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.69035551
28	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.58036950
29	STAT1_20625510_ChIP-Seq_HELA_Human	1.55291754
30	STAT3_18555785_ChIP-Seq_MESCs_Mouse	1.54206818
31	TCF4_23295773_ChIP-Seq_U87_Human	1.50781709
32	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.46897691
33	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.45999238
34	VDR_22108803_ChIP-Seq_LS180_Human	1.40255369
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.40165576
36	STAT3_23295773_ChIP-Seq_U87_Human	1.39851892
37	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.38778404
38	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.36368313
39	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.35936753
40	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.35396581
41	OCT4_20526341_ChIP-Seq_ESCs_Human	1.35316044
42	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.33345163
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.32480692
44	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.32332403
45	AR_25329375_ChIP-Seq_VCAP_Human	1.30616661
46	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.30427270
47	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.30289531
48	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.29409718
49	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.29289277
50	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.29171278
51	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.28384581
52	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.27868855
53	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.27849222
54	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.27687962
55	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.26707590
56	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.26451263
57	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.25958106
58	AR_19668381_ChIP-Seq_PC3_Human	1.25369504
59	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.25230393
60	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.21264099
61	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.21018119
62	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.17259341
63	NCOR_22424771_ChIP-Seq_293T_Human	1.15046475
64	SMAD4_21799915_ChIP-Seq_A2780_Human	1.14448784
65	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.13992618
66	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.11319660
67	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.09529851
68	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.08524330
69	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.08275892
70	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06853318
71	REST_21632747_ChIP-Seq_MESCs_Mouse	1.06429550
72	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.05564231
73	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.05465079
74	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.04514594
75	TCF4_22108803_ChIP-Seq_LS180_Human	1.04403611
76	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.03727363
77	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.02867112
78	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.02867112
79	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.02286106
80	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.01970708
81	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.01353791
82	CEBPB_22108803_ChIP-Seq_LS180_Human	1.00750255
83	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.00616735
84	TP53_18474530_ChIP-ChIP_U2OS_Human	1.00441331
85	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.00347681
86	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.99807152
87	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.99100782
88	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.98377178
89	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.98299206
90	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97214743
91	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.97059641
92	P53_21459846_ChIP-Seq_SAOS-2_Human	0.96385079
93	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.95251580
94	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.94270760
95	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.93949699
96	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.93804742
97	STAT1_17558387_ChIP-Seq_HELA_Human	0.93715588
98	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.93425028
99	MYC_19829295_ChIP-Seq_ESCs_Human	0.92647027
100	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.92273713

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	9.58219665
2	MP0003136_yellow_coat_color	7.95206179
3	MP0005171_absent_coat_pigmentation	7.49052855
4	MP0002653_abnormal_ependyma_morphology	6.02776704
5	MP0003890_abnormal_embryonic-extraembry	4.65045464
6	MP0003045_fibrosis	4.54811244
7	MP0003646_muscle_fatigue	4.06666756
8	MP0003879_abnormal_hair_cell	3.43531637
9	MP0004381_abnormal_hair_follicle	2.97761163
10	MP0000569_abnormal_digit_pigmentation	2.89335631
11	MP0002138_abnormal_hepatobiliary_system	2.44850575
12	MP0005670_abnormal_white_adipose	2.30632981
13	MP0005085_abnormal_gallbladder_physiolo	2.16734620
14	MP0003705_abnormal_hypodermis_morpholog	2.12642701
15	MP0000749_muscle_degeneration	2.11506349
16	MP0002938_white_spotting	1.99038036
17	MP0004147_increased_porphyrin_level	1.98831466
18	MP0005075_abnormal_melanosome_morpholog	1.96193830
19	MP0002168_other_aberrant_phenotype	1.86973872
20	MP0010352_gastrointestinal_tract_polyps	1.56116088
21	MP0003195_calcinosis	1.42624390
22	MP0005365_abnormal_bile_salt	1.38619788
23	MP0002095_abnormal_skin_pigmentation	1.27864915
24	MP0002160_abnormal_reproductive_system	1.17981034
25	MP0002075_abnormal_coat/hair_pigmentati	1.16064348
26	MP0004233_abnormal_muscle_weight	1.15678074
27	MP0003137_abnormal_impulse_conducting	1.12406582
28	MP0005395_other_phenotype	1.06589361
29	MP0002735_abnormal_chemical_nociception	1.06117073
30	MP0005330_cardiomyopathy	0.99716363
31	MP0002269_muscular_atrophy	0.94730570
32	MP0004043_abnormal_pH_regulation	0.93464999
33	MP0001501_abnormal_sleep_pattern	0.87933250
34	MP0006054_spinal_hemorrhage	0.86302019
35	MP0005174_abnormal_tail_pigmentation	0.85517276
36	MP0002254_reproductive_system_inflammat	0.82554780
37	MP0001186_pigmentation_phenotype	0.80379318
38	MP0008569_lethality_at_weaning	0.77072596
39	MP0001984_abnormal_olfaction	0.74383240
40	MP0000427_abnormal_hair_cycle	0.71615522
41	MP0003252_abnormal_bile_duct	0.70321412
42	MP0001486_abnormal_startle_reflex	0.69854891
43	MP0002272_abnormal_nervous_system	0.66437085
44	MP0002876_abnormal_thyroid_physiology	0.66263473
45	MP0001324_abnormal_eye_pigmentation	0.65888027
46	MP0000534_abnormal_ureter_morphology	0.65083779
47	MP0008770_decreased_survivor_rate	0.61465215
48	MP0005319_abnormal_enzyme/_coenzyme	0.59774239
49	MP0003300_gastrointestinal_ulcer	0.59074844
50	MP0003878_abnormal_ear_physiology	0.57694078
51	MP0005377_hearing/vestibular/ear_phenot	0.57694078
52	MP0001970_abnormal_pain_threshold	0.56537591
53	MP0009745_abnormal_behavioral_response	0.55101103
54	MP0000015_abnormal_ear_pigmentation	0.53381662
55	MP0005389_reproductive_system_phenotype	0.51063499
56	MP0002971_abnormal_brown_adipose	0.50323465
57	MP0002332_abnormal_exercise_endurance	0.50054993
58	MP0005076_abnormal_cell_differentiation	0.49414749
59	MP0009764_decreased_sensitivity_to	0.46708612
60	MP0004130_abnormal_muscle_cell	0.45084668
61	MP0002064_seizures	0.44430440
62	MP0002396_abnormal_hematopoietic_system	0.43862525
63	MP0002733_abnormal_thermal_nociception	0.43830955
64	MP0003937_abnormal_limbs/digits/tail_de	0.43487801
65	MP0009046_muscle_twitch	0.42529470
66	MP0001661_extended_life_span	0.41605828
67	MP0004142_abnormal_muscle_tone	0.41454613
68	MP0002572_abnormal_emotion/affect_behav	0.39699731
69	MP0002277_abnormal_respiratory_mucosa	0.39089718
70	MP0002928_abnormal_bile_duct	0.38872891
71	MP0005551_abnormal_eye_electrophysiolog	0.38778096
72	MP0005410_abnormal_fertilization	0.38664261
73	MP0002229_neurodegeneration	0.37537725
74	MP0003950_abnormal_plasma_membrane	0.36876666
75	MP0005646_abnormal_pituitary_gland	0.34852444
76	MP0008872_abnormal_physiological_respon	0.33728904
77	MP0009115_abnormal_fat_cell	0.32578536
78	MP0003632_abnormal_nervous_system	0.32142997
79	MP0002751_abnormal_autonomic_nervous	0.32137168
80	MP0008874_decreased_physiological_sensi	0.31909109
81	MP0003635_abnormal_synaptic_transmissio	0.30873812
82	MP0000026_abnormal_inner_ear	0.30349570
83	MP0005266_abnormal_metabolism	0.29385444
84	MP0002106_abnormal_muscle_physiology	0.28257256
85	MP0000377_abnormal_hair_follicle	0.27344109
86	MP0003959_abnormal_lean_body	0.26859733
87	MP0004484_altered_response_of	0.25529485
88	MP0006276_abnormal_autonomic_nervous	0.24724833
89	MP0005535_abnormal_body_temperature	0.23841263
90	MP0003385_abnormal_body_wall	0.22392646
91	MP0000778_abnormal_nervous_system	0.21646381
92	MP0001963_abnormal_hearing_physiology	0.21609280
93	MP0000470_abnormal_stomach_morphology	0.20308709
94	MP0002752_abnormal_somatic_nervous	0.19592290
95	MP0005448_abnormal_energy_balance	0.18955496
96	MP0005620_abnormal_muscle_contractility	0.18051917
97	MP0008932_abnormal_embryonic_tissue	0.17962102
98	MP0010307_abnormal_tumor_latency	0.17878349
99	MP0000432_abnormal_head_morphology	0.17478819
100	MP0002882_abnormal_neuron_morphology	0.17397982

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	7.86431341
2	Acanthocytosis (HP:0001927)	7.75492318
3	Parakeratosis (HP:0001036)	7.30901308
4	Aplastic anemia (HP:0001915)	6.40372167
5	Dialeptic seizures (HP:0011146)	5.01598184
6	Proximal amyotrophy (HP:0007126)	4.91557105
7	Rectal prolapse (HP:0002035)	4.47374944
8	Colon cancer (HP:0003003)	4.45636347
9	Congenital ichthyosiform erythroderma (HP:0007431)	4.44936316
10	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.42429546
11	Focal seizures (HP:0007359)	4.37024260
12	Vertebral arch anomaly (HP:0008438)	4.31111485
13	Spontaneous hematomas (HP:0007420)	4.14658631
14	Scapular winging (HP:0003691)	4.12574794
15	Aplasia/Hypoplasia of the uvula (HP:0010293)	4.11460324
16	Hematochezia (HP:0002573)	4.06580834
17	Erythroderma (HP:0001019)	3.86053441
18	Difficulty walking (HP:0002355)	3.83475428
19	Pancreatic cysts (HP:0001737)	3.66243956
20	Potter facies (HP:0002009)	3.33785231
21	Facial shape deformation (HP:0011334)	3.33785231
22	Ulnar bowing (HP:0003031)	3.32344060
23	Poikilocytosis (HP:0004447)	3.31022553
24	Bilateral sensorineural hearing impairment (HP:0008619)	3.27148208
25	Conjunctival telangiectasia (HP:0000524)	3.26671410
26	Ulnar claw (HP:0001178)	3.26567150
27	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.26252334
28	Overlapping toe (HP:0001845)	3.24764468
29	Esophageal varix (HP:0002040)	3.14787911
30	Enlarged kidneys (HP:0000105)	3.12670497
31	Pendular nystagmus (HP:0012043)	3.10677597
32	Radial bowing (HP:0002986)	3.08769608
33	Synostosis of carpal bones (HP:0005048)	2.94171839
34	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.91347566
35	Broad ribs (HP:0000885)	2.85624547
36	Abnormality of the renal cortex (HP:0011035)	2.72041037
37	Abnormality of the vocal cords (HP:0008777)	2.70368618
38	Hypoplastic iliac wings (HP:0002866)	2.62887904
39	Severe visual impairment (HP:0001141)	2.57942252
40	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.57220910
41	Petechiae (HP:0000967)	2.53404747
42	IgM deficiency (HP:0002850)	2.52411862
43	Peripheral hypomyelination (HP:0007182)	2.48819919
44	Abnormality of the shoulder girdle musculature (HP:0001435)	2.45082307
45	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.44583555
46	Tarsal synostosis (HP:0008368)	2.41966425
47	Progressive inability to walk (HP:0002505)	2.41154261
48	Gangrene (HP:0100758)	2.33708423
49	Abnormality of the renal medulla (HP:0100957)	2.33224140
50	Portal hypertension (HP:0001409)	2.31108533
51	Abnormality of macular pigmentation (HP:0008002)	2.24766501
52	Chromsome breakage (HP:0040012)	2.22579692
53	Lack of skin elasticity (HP:0100679)	2.22207772
54	Synostosis involving bones of the lower limbs (HP:0009138)	2.19232110
55	Synostosis involving bones of the feet (HP:0009140)	2.19232110
56	Hypokalemia (HP:0002900)	2.15258757
57	Autoimmune hemolytic anemia (HP:0001890)	2.13978892
58	Decreased circulating renin level (HP:0003351)	2.12029415
59	Abnormality of the hepatic vasculature (HP:0006707)	2.09725198
60	Cerebellar dysplasia (HP:0007033)	2.09492599
61	Dehydration (HP:0001944)	2.08541884
62	Thickened calvaria (HP:0002684)	2.05836396
63	Hypoalbuminemia (HP:0003073)	2.03097307
64	Abnormal albumin level (HP:0012116)	2.03097307
65	Type I transferrin isoform profile (HP:0003642)	2.02615288
66	Colitis (HP:0002583)	2.02089579
67	Gastrointestinal stroma tumor (HP:0100723)	2.01780909
68	Amelogenesis imperfecta (HP:0000705)	10.3211598
69	Focal motor seizures (HP:0011153)	10.2819354
70	Tubulointerstitial fibrosis (HP:0005576)	1.99444620
71	Recurrent sinusitis (HP:0011108)	1.96321155
72	Abnormality of potassium homeostasis (HP:0011042)	1.92275949
73	Visceral angiomatosis (HP:0100761)	1.91903281
74	Cystic liver disease (HP:0006706)	1.91117713
75	Chronic diarrhea (HP:0002028)	1.88897937
76	Right ventricular cardiomyopathy (HP:0011663)	1.88781436
77	Nephronophthisis (HP:0000090)	1.88160928
78	Bowed forearm bones (HP:0003956)	1.88123825
79	Bowing of the arm (HP:0006488)	1.88123825
80	Hemangiomatosis (HP:0007461)	1.87409574
81	Carpal synostosis (HP:0009702)	1.86398846
82	Palmoplantar keratoderma (HP:0000982)	1.86283284
83	Tubular atrophy (HP:0000092)	1.84151205
84	Retinitis pigmentosa (HP:0000510)	1.83878089
85	Purpura (HP:0000979)	1.81751231
86	Opisthotonus (HP:0002179)	1.81747045
87	Albinism (HP:0001022)	1.80449557
88	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.79353323
89	Stomach cancer (HP:0012126)	1.79241748
90	Inability to walk (HP:0002540)	1.77451916
91	Asymmetric septal hypertrophy (HP:0001670)	1.77240162
92	Neoplasm of the small intestine (HP:0100833)	1.75553229
93	Pancytopenia (HP:0001876)	1.75506814
94	Neoplasm of the colon (HP:0100273)	1.70786128
95	Lipoatrophy (HP:0100578)	1.68808106
96	Aortic valve stenosis (HP:0001650)	1.67330071
97	Neoplasm of the adrenal cortex (HP:0100641)	1.66758854
98	Ulnar deviation of finger (HP:0009465)	1.63283450
99	Abnormality of the wing of the ilium (HP:0011867)	1.63142292
100	Posterior embryotoxon (HP:0000627)	1.62110435

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK38L	7.35269876
2	LATS2	6.91986565
3	ZAK	3.18478453
4	PRKD3	3.08143918
5	STK38	2.79486794
6	ACVR1B	2.48017032
7	NLK	2.37736061
8	MAP2K2	2.15413278
9	STK3	2.13648065
10	FRK	2.06912587
11	LATS1	10.9230007
12	MELK	1.87169767
13	BMPR1B	1.64066772
14	MAP3K2	1.20553305
15	NEK2	1.11353670
16	KSR2	1.07473174
17	TAF1	1.04770555
18	PDPK1	1.00030571
19	IRAK3	0.98766740
20	PRKAA2	0.94317769
21	PIK3CG	0.92878076
22	GRK7	0.86226374
23	TGFBR1	0.79250516
24	PINK1	0.78447994
25	EIF2AK3	0.74620145
26	CSNK1A1L	0.69525729
27	PRKD1	0.62841403
28	TGFBR2	0.58385857
29	TTK	0.58078964
30	DAPK2	0.55789474
31	ADRBK1	0.53445958
32	NME1	0.51570261
33	MOS	0.50913256
34	NEK9	0.46514628
35	ADRBK2	0.45150443
36	MAP2K1	0.41070542
37	GRK5	0.40405235
38	WNK4	0.35548313
39	STK10	0.33012470
40	STK11	0.32305981
41	TNK2	0.31103042
42	PIM1	0.29196828
43	CHEK2	0.22017100
44	PLK1	0.21614900
45	CSNK1D	0.21515577
46	CDK3	0.20105533
47	PRKCI	0.18538378
48	OXSR1	0.17686240
49	TAOK3	0.12505914
50	STK39	0.12042426
51	WNK3	0.11984416
52	MAPK3	0.11791066
53	ITK	0.09896692
54	AKT2	0.09845205
55	ABL1	0.06885980
56	PRKACA	0.06592380
57	CAMK2B	0.06334756
58	EIF2AK2	0.06160303
59	STK24	0.05971459
60	TXK	0.05332713
61	MAP3K8	0.05085902
62	PRKCE	0.04569108
63	CAMK2A	0.04252440
64	FER	0.04070336
65	MAP3K1	0.03917536
66	RET	0.03408214
67	MAPK1	0.03382881
68	TEC	0.02936173
69	PLK3	0.02851223
70	JAK2	0.01752869
71	PRKACB	0.01372259
72	PRKCG	0.00746051
73	PLK2	0.00421397
74	ATR	0.00103339
75	RPS6KA3	-0.0832953
76	DAPK1	-0.0811774
77	PAK1	-0.0803243
78	CAMK2D	-0.0764531
79	PRKCB	-0.0727378
80	ATM	-0.0641829
81	EPHA4	-0.0574415
82	NEK6	-0.0536543
83	MAP3K7	-0.0529179
84	PDK1	-0.0455343
85	PRKG2	-0.0442363
86	NEK1	-0.0436086
87	GSK3B	-0.0376091
88	AKT1	-0.0357055
89	NTRK2	-0.0353365
90	MKNK2	-0.0285655
91	PDGFRA	-0.0270412
92	CSNK1A1	-0.0251031
93	CDK19	-0.0228623
94	GRK1	-0.0207976
95	CDK5	-0.0156586
96	PRKCH	-0.0150899
97	MAPK7	-0.0069908
98	NTRK3	-0.0069243
99	MAPK8	-0.0026041
100	MARK1	-0.0013170

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	9.04092454
2	Phototransduction_Homo sapiens_hsa04744	4.59120855
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.89893783
4	Sphingolipid metabolism_Homo sapiens_hsa00600	3.86442741
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.28223188
6	Nicotine addiction_Homo sapiens_hsa05033	2.88035109
7	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.78467986
8	Phenylalanine metabolism_Homo sapiens_hsa00360	2.18884112
9	Taste transduction_Homo sapiens_hsa04742	2.14177241
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.13716267
11	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.06900690
12	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.99919374
13	Morphine addiction_Homo sapiens_hsa05032	1.83104999
14	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.60002107
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.59084520
16	GABAergic synapse_Homo sapiens_hsa04727	1.41492523
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.32244392
18	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.28275136
19	Histidine metabolism_Homo sapiens_hsa00340	1.21772004
20	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.18313219
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.16709615
22	Calcium signaling pathway_Homo sapiens_hsa04020	1.15698311
23	One carbon pool by folate_Homo sapiens_hsa00670	1.13753899
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.13383447
25	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.07553624
26	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.00200691
27	Sphingolipid signaling pathway_Homo sapiens_hsa04071	1.00120649
28	Viral myocarditis_Homo sapiens_hsa05416	0.97845817
29	VEGF signaling pathway_Homo sapiens_hsa04370	0.97079537
30	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.96437737
31	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.94337336
32	Tyrosine metabolism_Homo sapiens_hsa00350	0.89774145
33	Glutamatergic synapse_Homo sapiens_hsa04724	0.85351780
34	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.83124864
35	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.82170840
36	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.79865161
37	Butanoate metabolism_Homo sapiens_hsa00650	0.77676020
38	Serotonergic synapse_Homo sapiens_hsa04726	0.77246971
39	Nitrogen metabolism_Homo sapiens_hsa00910	0.75993069
40	Bile secretion_Homo sapiens_hsa04976	0.75659751
41	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.75526248
42	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.74196572
43	ABC transporters_Homo sapiens_hsa02010	0.68771472
44	Basal transcription factors_Homo sapiens_hsa03022	0.66700417
45	Glycerolipid metabolism_Homo sapiens_hsa00561	0.66047216
46	Adherens junction_Homo sapiens_hsa04520	0.65417154
47	Collecting duct acid secretion_Homo sapiens_hsa04966	0.64666616
48	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.64095859
49	ECM-receptor interaction_Homo sapiens_hsa04512	0.62211375
50	cAMP signaling pathway_Homo sapiens_hsa04024	0.59314936
51	Colorectal cancer_Homo sapiens_hsa05210	0.55531361
52	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.53432595
53	Pyruvate metabolism_Homo sapiens_hsa00620	0.52492997
54	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.51383388
55	Olfactory transduction_Homo sapiens_hsa04740	0.49409511
56	Thyroid cancer_Homo sapiens_hsa05216	0.49032295
57	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.48788258
58	Hippo signaling pathway_Homo sapiens_hsa04390	0.48689575
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.46791094
60	Lysine degradation_Homo sapiens_hsa00310	0.46449868
61	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.45652378
62	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.44244180
63	Fatty acid degradation_Homo sapiens_hsa00071	0.43446938
64	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.43407985
65	Salivary secretion_Homo sapiens_hsa04970	0.41943306
66	Homologous recombination_Homo sapiens_hsa03440	0.41700573
67	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.38468987
68	Circadian entrainment_Homo sapiens_hsa04713	0.35778708
69	African trypanosomiasis_Homo sapiens_hsa05143	0.34987304
70	Insulin secretion_Homo sapiens_hsa04911	0.34692008
71	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.34235549
72	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.33362759
73	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.32925474
74	Arginine and proline metabolism_Homo sapiens_hsa00330	0.32573738
75	Melanogenesis_Homo sapiens_hsa04916	0.30136348
76	Basal cell carcinoma_Homo sapiens_hsa05217	0.29214257
77	Pancreatic cancer_Homo sapiens_hsa05212	0.26618852
78	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.25453076
79	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.24977881
80	Tuberculosis_Homo sapiens_hsa05152	0.23273222
81	Cholinergic synapse_Homo sapiens_hsa04725	0.23146504
82	Gastric acid secretion_Homo sapiens_hsa04971	0.22358079
83	Gap junction_Homo sapiens_hsa04540	0.21912309
84	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.21851837
85	Retinol metabolism_Homo sapiens_hsa00830	0.21220317
86	Oocyte meiosis_Homo sapiens_hsa04114	0.19714073
87	Cell cycle_Homo sapiens_hsa04110	0.19077631
88	Estrogen signaling pathway_Homo sapiens_hsa04915	0.17553170
89	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.17471809
90	Metabolic pathways_Homo sapiens_hsa01100	0.16399165
91	Chemical carcinogenesis_Homo sapiens_hsa05204	0.15696984
92	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.15444752
93	Fanconi anemia pathway_Homo sapiens_hsa03460	0.14265173
94	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.13974693
95	Type II diabetes mellitus_Homo sapiens_hsa04930	0.11545325
96	Peroxisome_Homo sapiens_hsa04146	0.09985746
97	Folate biosynthesis_Homo sapiens_hsa00790	0.08879299
98	Selenocompound metabolism_Homo sapiens_hsa00450	0.08419330
99	Sulfur relay system_Homo sapiens_hsa04122	0.07393491
100	Linoleic acid metabolism_Homo sapiens_hsa00591	0.07007130

MAN1A2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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