MAN1B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1basement membrane organization (GO:0071711)3.98142035
2Golgi transport vesicle coating (GO:0048200)3.94623306
3COPI coating of Golgi vesicle (GO:0048205)3.94623306
4barbed-end actin filament capping (GO:0051016)3.92419356
5skin morphogenesis (GO:0043589)3.86108533
6positive regulation of histone deacetylation (GO:0031065)3.74598534
7activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.62316891
8peptidyl-lysine dimethylation (GO:0018027)3.62143763
9regulation of cholesterol homeostasis (GO:2000188)3.56698511
10regulation of fatty acid beta-oxidation (GO:0031998)3.56284854
11cytoskeletal anchoring at plasma membrane (GO:0007016)3.54250034
12positive regulation of nuclease activity (GO:0032075)3.49901132
13hemidesmosome assembly (GO:0031581)3.49540290
14negative regulation of cell size (GO:0045792)3.49106470
15alpha-linolenic acid metabolic process (GO:0036109)3.47206303
16semaphorin-plexin signaling pathway (GO:0071526)3.44461513
17epithelial cell differentiation involved in prostate gland development (GO:0060742)3.39116172
18apoptotic cell clearance (GO:0043277)3.38143910
19protein localization to endosome (GO:0036010)3.33519716
20regulation of extracellular matrix disassembly (GO:0010715)3.29691655
21response to laminar fluid shear stress (GO:0034616)3.25244681
22regulation of nuclease activity (GO:0032069)3.12027017
23maternal placenta development (GO:0001893)3.09930651
24low-density lipoprotein particle clearance (GO:0034383)3.09691546
25peptidyl-proline hydroxylation (GO:0019511)3.09555504
26endoplasmic reticulum unfolded protein response (GO:0030968)3.09501306
27dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.09442891
28regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.08817298
29mannose metabolic process (GO:0006013)3.05965470
30negative regulation of erythrocyte differentiation (GO:0045647)3.05165270
31lysine metabolic process (GO:0006553)3.03825042
32lysine catabolic process (GO:0006554)3.03825042
33regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.03719874
34endothelial cell chemotaxis (GO:0035767)3.01655144
35endodermal cell differentiation (GO:0035987)2.97028221
36pinocytosis (GO:0006907)2.96628902
37adherens junction assembly (GO:0034333)2.95878478
38positive regulation of fatty acid beta-oxidation (GO:0032000)2.95527425
39positive regulation of blood vessel endothelial cell migration (GO:0043536)2.93794832
40cellular response to unfolded protein (GO:0034620)2.91644872
41regulation of translational fidelity (GO:0006450)2.90685246
42negative regulation of fatty acid transport (GO:2000192)2.90476938
43planar cell polarity pathway involved in neural tube closure (GO:0090179)2.90024032
44negative regulation of fibrinolysis (GO:0051918)2.89699839
45insulin-like growth factor receptor signaling pathway (GO:0048009)2.89252050
46negative regulation of lipid transport (GO:0032369)2.87389255
47proline biosynthetic process (GO:0006561)2.86282739
48ER-nucleus signaling pathway (GO:0006984)2.86249116
494-hydroxyproline metabolic process (GO:0019471)2.86127261
50macroautophagy (GO:0016236)2.85904912
51positive regulation of receptor recycling (GO:0001921)2.85624977
52retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.83315098
53regulation of translational termination (GO:0006449)2.82389291
54regulation of hippo signaling (GO:0035330)2.80705010
55glucocorticoid receptor signaling pathway (GO:0042921)2.79140748
56protein maturation by protein folding (GO:0022417)2.78299470
57NLS-bearing protein import into nucleus (GO:0006607)2.78069017
58dicarboxylic acid biosynthetic process (GO:0043650)2.74968026
59negative regulation of sterol transport (GO:0032372)2.74474943
60negative regulation of cholesterol transport (GO:0032375)2.74474943
61regulation of glucose import in response to insulin stimulus (GO:2001273)2.74421915
62receptor catabolic process (GO:0032801)2.73969132
63pre-miRNA processing (GO:0031054)2.72568510
64maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.72516325
65positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.72017403
66embryo implantation (GO:0007566)2.69532963
67regulation of early endosome to late endosome transport (GO:2000641)2.69430124
68stress fiber assembly (GO:0043149)2.68666053
69regulation of cholesterol biosynthetic process (GO:0045540)2.67955692
70hippo signaling (GO:0035329)2.67525487
71membrane protein ectodomain proteolysis (GO:0006509)2.66916837
72regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.66887646
73cellular response to topologically incorrect protein (GO:0035967)2.66521144
74cell adhesion mediated by integrin (GO:0033627)2.66492179
75desmosome organization (GO:0002934)2.65111919
76positive regulation of extracellular matrix organization (GO:1903055)2.64753514
77amyloid precursor protein catabolic process (GO:0042987)2.64423838
78apoptotic process involved in morphogenesis (GO:0060561)2.63968365
79positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.63563350
80positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.63349426
81positive regulation of glycogen biosynthetic process (GO:0045725)2.61762917
82hyaluronan catabolic process (GO:0030214)2.61620592
83positive regulation of Cdc42 GTPase activity (GO:0043089)2.60610499
84heterochromatin organization (GO:0070828)2.59186820
85vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.58946561
86vascular endothelial growth factor signaling pathway (GO:0038084)2.58636927
87regulation of cholesterol storage (GO:0010885)2.57733637
88pentose-phosphate shunt (GO:0006098)2.56798688
89glucose 6-phosphate metabolic process (GO:0051156)2.54782850
90antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.54596845
91antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.54596845
92cell-substrate junction assembly (GO:0007044)2.52950769
93regulation of extracellular matrix organization (GO:1903053)2.52885923
94growth hormone receptor signaling pathway (GO:0060396)2.52196498
95type B pancreatic cell proliferation (GO:0044342)2.52094516
96endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.51975071
97activation of Rac GTPase activity (GO:0032863)2.51579186
98L-alpha-amino acid transmembrane transport (GO:1902475)2.51410412
99embryonic foregut morphogenesis (GO:0048617)2.50717227
100sulfur amino acid catabolic process (GO:0000098)2.50375500
101regulation of mammary gland epithelial cell proliferation (GO:0033599)2.49539911
102glial cell proliferation (GO:0014009)2.49492132
103UV protection (GO:0009650)2.49466620
104positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.49322007
105focal adhesion assembly (GO:0048041)2.49095865
106cell-substrate adherens junction assembly (GO:0007045)2.49095865
107maintenance of protein localization in organelle (GO:0072595)2.48111754
108protein retention in ER lumen (GO:0006621)2.47605179
109retrograde transport, endosome to Golgi (GO:0042147)2.47252601
110urea cycle (GO:0000050)2.47090837
111urea metabolic process (GO:0019627)2.47090837
112negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.46612054
113protein heterotrimerization (GO:0070208)2.43467931
114atrioventricular valve morphogenesis (GO:0003181)2.42233855
115glycine metabolic process (GO:0006544)2.41414667
1162-oxoglutarate metabolic process (GO:0006103)2.40755854
117positive regulation of protein deacetylation (GO:0090312)2.40690616
118cortical actin cytoskeleton organization (GO:0030866)2.40348641
119collagen metabolic process (GO:0032963)2.39892053
120adhesion of symbiont to host (GO:0044406)2.39484061
121glucose catabolic process (GO:0006007)2.39338079
122positive regulation of triglyceride biosynthetic process (GO:0010867)2.39008147
123extracellular matrix disassembly (GO:0022617)2.38757725
124response to endoplasmic reticulum stress (GO:0034976)2.38483987
125cellular copper ion homeostasis (GO:0006878)2.38410678
126positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.38348915
127actin filament depolymerization (GO:0030042)2.37753453
128cell-cell junction maintenance (GO:0045217)2.37753188
129vesicle coating (GO:0006901)2.37738839
130fatty acid homeostasis (GO:0055089)2.37169689
131collagen fibril organization (GO:0030199)2.36506006
132regulation of polysaccharide biosynthetic process (GO:0032885)2.36231444
133fibril organization (GO:0097435)2.35838079
134extracellular fibril organization (GO:0043206)2.35781322
135protein targeting to plasma membrane (GO:0072661)2.35722966
136sexual reproduction (GO:0019953)2.35706828
137modulation by symbiont of host cellular process (GO:0044068)2.35369518
138germ cell migration (GO:0008354)2.35248208
139triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.32919290
140embryonic process involved in female pregnancy (GO:0060136)2.32792627
141mRNA stabilization (GO:0048255)2.32606058
142RNA stabilization (GO:0043489)2.32606058
143peptidyl-glutamic acid carboxylation (GO:0017187)2.32579075
144protein carboxylation (GO:0018214)2.32579075
145epithelial cell-cell adhesion (GO:0090136)2.31418450
146sodium ion export (GO:0071436)2.31120164
147substrate-dependent cell migration (GO:0006929)2.31023525
148establishment of apical/basal cell polarity (GO:0035089)2.27598729
149cellular response to epidermal growth factor stimulus (GO:0071364)2.25585457
150antigen processing and presentation of endogenous antigen (GO:0019883)2.25236941
151regulation of chromatin binding (GO:0035561)2.25028240
152tricarboxylic acid metabolic process (GO:0072350)2.23281149
153NADPH regeneration (GO:0006740)2.22342293
154blood vessel endothelial cell migration (GO:0043534)2.21840335
155establishment of nucleus localization (GO:0040023)2.21690690
156midgut development (GO:0007494)2.21545907
157mitotic G1 DNA damage checkpoint (GO:0031571)2.20993362
158protein hydroxylation (GO:0018126)2.20897801
159cell migration involved in sprouting angiogenesis (GO:0002042)2.19488545
160corticosteroid receptor signaling pathway (GO:0031958)2.19127776
161fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.18870410
162positive regulation of glycogen metabolic process (GO:0070875)2.18458103

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.78299601
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.55062939
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.32740136
4MYC_22102868_ChIP-Seq_BL_Human2.85761485
5CLOCK_20551151_ChIP-Seq_293T_Human2.62852749
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.61167075
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.60640332
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.52037735
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.33073900
10KDM2B_26808549_Chip-Seq_DND41_Human2.30988644
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.24219078
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.22942576
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.22179335
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.20871280
15ZNF263_19887448_ChIP-Seq_K562_Human2.19452261
16TCF7_22412390_ChIP-Seq_EML_Mouse2.17902695
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.15660424
18KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.12976181
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.05389098
20LXR_22292898_ChIP-Seq_THP-1_Human1.95301199
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93442584
22KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.93064837
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.92503331
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.87223074
25VDR_21846776_ChIP-Seq_THP-1_Human1.84193643
26ZFP281_18757296_ChIP-ChIP_E14_Mouse1.82222791
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.80863516
28P300_27058665_Chip-Seq_ZR-75-30cells_Human1.77204508
29TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76503158
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69893440
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.68361926
32RACK7_27058665_Chip-Seq_MCF-7_Human1.68267876
33KDM2B_26808549_Chip-Seq_K562_Human1.66772621
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.61990841
35KDM2B_26808549_Chip-Seq_JURKAT_Human1.60246187
36NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.57075411
37DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.56020965
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.55204332
39TET1_21451524_ChIP-Seq_MESCs_Mouse1.52340455
40E2F7_22180533_ChIP-Seq_HELA_Human1.50540708
41KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.50124855
42ATF3_27146783_Chip-Seq_COLON_Human1.49580758
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.48690619
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.47832922
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47241952
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45572651
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.44018216
48ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.41789190
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41065159
50MAF_26560356_Chip-Seq_TH1_Human1.39701478
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.38427959
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38416116
53SA1_27219007_Chip-Seq_ERYTHROID_Human1.37831276
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37769483
55E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37347972
56EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37008663
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36202317
58CREB1_26743006_Chip-Seq_LNCaP_Human1.35621529
59* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34136412
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33149847
61UTX_26944678_Chip-Seq_JUKART_Human1.32856363
62* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31113101
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30891577
64NCOR1_26117541_ChIP-Seq_K562_Human1.30737890
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30572630
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29989841
67ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.29349599
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26973654
69RUNX1_27514584_Chip-Seq_MCF-7_Human1.26376996
70* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25054798
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24080904
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21920137
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21777779
74FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.20493009
75CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20258232
76TP53_22127205_ChIP-Seq_IMR90_Human1.17216908
77SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16515803
78SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16291022
79MAF_26560356_Chip-Seq_TH2_Human1.16207998
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16142128
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.16094569
82FOXA2_19822575_ChIP-Seq_HepG2_Human1.15938067
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15673051
84POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15591880
85TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.15344995
86MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15060925
87* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14456628
88* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13027263
89UBF1/2_26484160_Chip-Seq_HMECs_Human1.12490188
90RUNX1_22412390_ChIP-Seq_EML_Mouse1.12092381
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12090639
92GATA1_19941826_ChIP-Seq_K562_Human1.10784663
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10202718
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09714208
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09707658
96P68_20966046_ChIP-Seq_HELA_Human1.09509888
97TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.09422406
98FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08861812
99UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08591941
100GATA6_25053715_ChIP-Seq_YYC3_Human1.08540294
101HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08457397
102ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07007454
103STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06864024
104NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06516428
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06009372
106GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05725903
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05139152
108EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04656210
109CHD1_26751641_Chip-Seq_LNCaP_Human1.03765849
110AR_21909140_ChIP-Seq_LNCAP_Human1.03600540
111* GATA1_19941827_ChIP-Seq_MEL_Mouse1.03436265
112SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02678645
113P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02369666
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01346637
115SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00699786
116* TET1_21490601_ChIP-Seq_MESCs_Mouse0.99877390
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99767723
118TP63_22573176_ChIP-Seq_HFKS_Human0.99141929
119NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99090798
120TBX20_22080862_ChIP-Seq_HEART_Mouse0.98659953
121TBX20_22328084_ChIP-Seq_HEART_Mouse0.98659953
122* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98630007
123EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98233488
124GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98198040
125SMC4_20622854_ChIP-Seq_HELA_Human0.97960578
126GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96161165
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95950511
128ESR1_21235772_ChIP-Seq_MCF-7_Human0.95287103
129SPI1_23127762_ChIP-Seq_K562_Human0.94860654
130VDR_24763502_ChIP-Seq_THP-1_Human0.94197532
131CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92932383
132KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90628840
133PKCTHETA_26484144_Chip-Seq_BREAST_Human0.89831621
134BCOR_27268052_Chip-Seq_Bcells_Human0.89497823

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog5.07517281
2MP0010234_abnormal_vibrissa_follicle3.35418766
3MP0002139_abnormal_hepatobiliary_system3.32279693
4MP0003300_gastrointestinal_ulcer3.19919500
5MP0005360_urolithiasis2.79326555
6MP0010352_gastrointestinal_tract_polyps2.75898953
7MP0008438_abnormal_cutaneous_collagen2.72824988
8MP0005257_abnormal_intraocular_pressure2.57643361
9MP0005076_abnormal_cell_differentiation2.54209971
10MP0005451_abnormal_body_composition2.36679902
11MP0008260_abnormal_autophagy2.35893695
12MP0009840_abnormal_foam_cell2.26544601
13MP0003566_abnormal_cell_adhesion2.21230467
14MP0003283_abnormal_digestive_organ2.15614037
15MP0008961_abnormal_basal_metabolism2.11851628
16MP0003252_abnormal_bile_duct2.11451869
17MP0009384_cardiac_valve_regurgitation2.05602669
18MP0003303_peritoneal_inflammation2.02100271
19MP0005365_abnormal_bile_salt2.00639895
20MP0002877_abnormal_melanocyte_morpholog1.97506087
21MP0000537_abnormal_urethra_morphology1.96533938
22MP0006054_spinal_hemorrhage1.89420906
23MP0005085_abnormal_gallbladder_physiolo1.79915244
24MP0010329_abnormal_lipoprotein_level1.77716051
25MP0009278_abnormal_bone_marrow1.74431408
26MP0010307_abnormal_tumor_latency1.73575310
27MP0005409_darkened_coat_color1.69090823
28MP0004185_abnormal_adipocyte_glucose1.65511863
29MP0000751_myopathy1.64794079
30MP0005623_abnormal_meninges_morphology1.63875253
31MP0004130_abnormal_muscle_cell1.61744090
32MP0003191_abnormal_cellular_cholesterol1.60960608
33MP0000858_altered_metastatic_potential1.60191662
34MP0001849_ear_inflammation1.54965762
35MP0000569_abnormal_digit_pigmentation1.52833268
36MP0005503_abnormal_tendon_morphology1.50908063
37MP0003436_decreased_susceptibility_to1.49567549
38MP0000733_abnormal_muscle_development1.46969175
39MP0003091_abnormal_cell_migration1.45035301
40MP0005083_abnormal_biliary_tract1.45002200
41MP0000767_abnormal_smooth_muscle1.43733294
42MP0009780_abnormal_chondrocyte_physiolo1.39557791
43MP0003045_fibrosis1.36705841
44MP0004858_abnormal_nervous_system1.36396455
45MP0004264_abnormal_extraembryonic_tissu1.36193985
46MP0001666_abnormal_nutrient_absorption1.34540420
47MP0003172_abnormal_lysosome_physiology1.34409636
48MP0005666_abnormal_adipose_tissue1.33657018
49MP0001958_emphysema1.30014819
50MP0000609_abnormal_liver_physiology1.29633441
51MP0005023_abnormal_wound_healing1.28633685
52MP0005275_abnormal_skin_tensile1.28255865
53MP0000003_abnormal_adipose_tissue1.21970564
54MP0005375_adipose_tissue_phenotype1.21352564
55MP0009053_abnormal_anal_canal1.20374224
56MP0004272_abnormal_basement_membrane1.20274649
57MP0005058_abnormal_lysosome_morphology1.20210053
58MP0001243_abnormal_dermal_layer1.17100181
59MP0003115_abnormal_respiratory_system1.15876330
60MP0010368_abnormal_lymphatic_system1.12598313
61MP0010030_abnormal_orbit_morphology1.11595975
62MP0004197_abnormal_fetal_growth/weight/1.11155378
63MP0001915_intracranial_hemorrhage1.10634353
64MP0002796_impaired_skin_barrier1.10492416
65MP0005167_abnormal_blood-brain_barrier1.04548400
66MP0002653_abnormal_ependyma_morphology1.03417119
67MP0002896_abnormal_bone_mineralization1.02514595
68MP0000013_abnormal_adipose_tissue1.02498477
69MP0005187_abnormal_penis_morphology1.01840230
70MP0002086_abnormal_extraembryonic_tissu1.01513267
71MP0002909_abnormal_adrenal_gland1.01178154
72MP0005501_abnormal_skin_physiology1.00952487
73MP0002138_abnormal_hepatobiliary_system1.00903100
74MP0002998_abnormal_bone_remodeling1.00739696
75MP0000678_abnormal_parathyroid_gland0.98836226
76MP0001730_embryonic_growth_arrest0.97032447
77MP0000604_amyloidosis0.96200689
78MP0005670_abnormal_white_adipose0.94777780
79MP0005508_abnormal_skeleton_morphology0.94110418
80MP0001348_abnormal_lacrimal_gland0.93824981
81MP0001533_abnormal_skeleton_physiology0.92867429
82MP0003183_abnormal_peptide_metabolism0.92290316
83MP0005621_abnormal_cell_physiology0.91999087
84MP0004233_abnormal_muscle_weight0.91987958
85MP0002933_joint_inflammation0.91871924
86MP0001542_abnormal_bone_strength0.91676955
87MP0009672_abnormal_birth_weight0.91476211
88MP0003634_abnormal_glial_cell0.91256981
89MP0003279_aneurysm0.91073861
90MP0000598_abnormal_liver_morphology0.89539690
91MP0004947_skin_inflammation0.88662679
92MP0002118_abnormal_lipid_homeostasis0.88459539
93MP0008875_abnormal_xenobiotic_pharmacok0.88458001
94MP0004808_abnormal_hematopoietic_stem0.85796445
95MP0002084_abnormal_developmental_patter0.84363639
96MP0003453_abnormal_keratinocyte_physiol0.83551479
97MP0002168_other_aberrant_phenotype0.83060714
98MP0009703_decreased_birth_body0.81742631
99MP0002089_abnormal_postnatal_growth/wei0.81545268
100MP0000428_abnormal_craniofacial_morphol0.81146768
101MP0003075_altered_response_to0.79013112
102MP0001216_abnormal_epidermal_layer0.78936625
103MP0005390_skeleton_phenotype0.78916344
104MP0009931_abnormal_skin_appearance0.77309110
105MP0002088_abnormal_embryonic_growth/wei0.76980538
106MP0002928_abnormal_bile_duct0.76504540
107MP0003984_embryonic_growth_retardation0.75657427
108MP0002254_reproductive_system_inflammat0.75554240
109MP0002295_abnormal_pulmonary_circulatio0.75351571
110MP0004510_myositis0.74774711
111MP0002092_abnormal_eye_morphology0.73818217
112MP0009643_abnormal_urine_homeostasis0.73640743
113MP0000750_abnormal_muscle_regeneration0.73604280
114MP0003448_altered_tumor_morphology0.73224425
115MP0006082_CNS_inflammation0.72931498
116MP0001614_abnormal_blood_vessel0.72834194
117MP0002166_altered_tumor_susceptibility0.72657887
118MP0002697_abnormal_eye_size0.72569135
119MP0002080_prenatal_lethality0.72357510
120MP0000534_abnormal_ureter_morphology0.72149658
121MP0000681_abnormal_thyroid_gland0.72085255
122MP0005319_abnormal_enzyme/_coenzyme0.71785061
123MP0000759_abnormal_skeletal_muscle0.71739757
124MP0001672_abnormal_embryogenesis/_devel0.71466718
125MP0005380_embryogenesis_phenotype0.71466718
126MP0002925_abnormal_cardiovascular_devel0.70313669
127MP0000371_diluted_coat_color0.70213502
128MP0005332_abnormal_amino_acid0.69834523
129MP0003795_abnormal_bone_structure0.69549257
130MP0000747_muscle_weakness0.69524555
131MP0001661_extended_life_span0.69422864
132MP0000462_abnormal_digestive_system0.68920306
133MP0003868_abnormal_feces_composition0.68558434
134MP0005464_abnormal_platelet_physiology0.68290150
135MP0008770_decreased_survivor_rate0.68067230
136MP0003329_amyloid_beta_deposits0.68026663
137MP0003119_abnormal_digestive_system0.67731572
138MP0002060_abnormal_skin_morphology0.67205273
139MP0005164_abnormal_response_to0.67032384
140MP0005220_abnormal_exocrine_pancreas0.66999062
141MP0000467_abnormal_esophagus_morphology0.65320573
142MP0001697_abnormal_embryo_size0.65230060
143MP0010771_integument_phenotype0.64459257
144MP0000762_abnormal_tongue_morphology0.63758513
145MP0002249_abnormal_larynx_morphology0.62733043
146MP0000249_abnormal_blood_vessel0.62433780
147MP0000579_abnormal_nail_morphology0.61604296
148MP0005330_cardiomyopathy0.60251278
149MP0010630_abnormal_cardiac_muscle0.59537704
150MP0005384_cellular_phenotype0.59524414
151MP0003828_pulmonary_edema0.59495390
152MP0006138_congestive_heart_failure0.59478747

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)4.03993488
2Vertebral compression fractures (HP:0002953)3.54427217
3Atrophic scars (HP:0001075)3.32420892
4Protrusio acetabuli (HP:0003179)3.25650749
5Hyperacusis (HP:0010780)3.23802728
6Deep venous thrombosis (HP:0002625)3.22409152
7Abnormality of the lower motor neuron (HP:0002366)3.12211512
8Shallow orbits (HP:0000586)3.09037438
9Hand muscle atrophy (HP:0009130)3.08065138
10Upper limb amyotrophy (HP:0009129)3.04233706
11Distal upper limb amyotrophy (HP:0007149)3.04233706
12Broad face (HP:0000283)2.96143292
13Fragile skin (HP:0001030)2.95745992
14Dysostosis multiplex (HP:0000943)2.92929640
15Vascular tortuosity (HP:0004948)2.81179184
16Arterial tortuosity (HP:0005116)2.78903580
17Spastic diplegia (HP:0001264)2.75197301
18Wormian bones (HP:0002645)2.68618669
19Short nail (HP:0001799)2.67076383
20Biconcave vertebral bodies (HP:0004586)2.64783291
21Subacute progressive viral hepatitis (HP:0006572)2.62992792
22Abnormality of dentin (HP:0010299)2.61412076
23Mitral valve prolapse (HP:0001634)2.58158718
24Aneurysm (HP:0002617)2.57659460
25Enlarged penis (HP:0000040)2.54523759
26Ankle contracture (HP:0006466)2.54333827
27Abnormality of liposaccharide metabolism (HP:0010968)2.53445644
28Abnormality of glycosphingolipid metabolism (HP:0004343)2.53445644
29Abnormality of glycolipid metabolism (HP:0010969)2.53445644
30Premature rupture of membranes (HP:0001788)2.53354229
31Renovascular hypertension (HP:0100817)2.48686479
32Bowel diverticulosis (HP:0005222)2.47814490
33Bladder diverticulum (HP:0000015)2.45078868
34Mitral regurgitation (HP:0001653)2.44526715
35J-shaped sella turcica (HP:0002680)2.44290010
36Aortic aneurysm (HP:0004942)2.43159839
37Elfin facies (HP:0004428)2.42837657
38Spinal rigidity (HP:0003306)2.42317947
39Insomnia (HP:0100785)2.40528314
40Flat acetabular roof (HP:0003180)2.37551206
41Joint stiffness (HP:0001387)2.37488357
42Abnormality of the Achilles tendon (HP:0005109)2.35529776
43Ulnar bowing (HP:0003031)2.33388557
44Distal lower limb amyotrophy (HP:0008944)2.32137996
45Macroorchidism (HP:0000053)2.29828399
46Lymphangioma (HP:0100764)2.29724292
47Achilles tendon contracture (HP:0001771)2.28447640
48Turricephaly (HP:0000262)2.28347085
49Back pain (HP:0003418)2.24586205
50Long toe (HP:0010511)2.22050152
51Dilatation of the ascending aorta (HP:0005111)2.21077590
52Neurofibrillary tangles (HP:0002185)2.19397164
53Hemorrhage of the eye (HP:0011885)2.17332313
54Pseudobulbar signs (HP:0002200)2.16941086
55Soft skin (HP:0000977)2.14546411
56Cerebral inclusion bodies (HP:0100314)2.13961882
57Renal duplication (HP:0000075)2.13421181
58Xanthomatosis (HP:0000991)2.12984866
59Natal tooth (HP:0000695)2.09651906
60Increased density of long bones (HP:0006392)2.07753064
61Mildly elevated creatine phosphokinase (HP:0008180)2.06344310
62Obstructive sleep apnea (HP:0002870)2.05084687
63Distal lower limb muscle weakness (HP:0009053)2.03959056
64Nuclear cataract (HP:0100018)2.03773426
65Heterotopia (HP:0002282)2.02593049
66Hematochezia (HP:0002573)2.01662444
67Joint laxity (HP:0001388)2.01354461
68Cervical subluxation (HP:0003308)2.00860044
69Striae distensae (HP:0001065)2.00024201
70Hallux valgus (HP:0001822)1.99255896
71Aortic dissection (HP:0002647)1.96990034
72Increased variability in muscle fiber diameter (HP:0003557)1.96750410
73Interstitial pulmonary disease (HP:0006530)1.96424202
74Elbow flexion contracture (HP:0002987)1.96089678
75Mitral stenosis (HP:0001718)1.95582365
76Abnormality of the acetabulum (HP:0003170)1.95231801
77Abnormality of monocarboxylic acid metabolism (HP:0010996)1.95136954
78Deviation of the hallux (HP:0010051)1.95115972
79Coxa vara (HP:0002812)1.94081800
80Genu recurvatum (HP:0002816)1.93929869
81Rectal prolapse (HP:0002035)1.93154043
82Thin bony cortex (HP:0002753)1.92732573
83Complement deficiency (HP:0004431)1.92314863
84Broad metatarsal (HP:0001783)1.92000442
85Peritonitis (HP:0002586)1.91067999
86Neonatal short-limb short stature (HP:0008921)1.90329425
87Overriding aorta (HP:0002623)1.90104446
88Myocardial infarction (HP:0001658)1.89028086
89Abnormality of the astrocytes (HP:0100707)1.88663492
90Astrocytoma (HP:0009592)1.88663492
91Resting tremor (HP:0002322)1.86459218
92Spondylolisthesis (HP:0003302)1.86287092
93Abnormal delivery (HP:0001787)1.85956445
94Aortic regurgitation (HP:0001659)1.85435459
95Increased CSF protein (HP:0002922)1.85423230
96Hyperextensible skin (HP:0000974)1.85225258
97Long palpebral fissure (HP:0000637)1.84114535
98Stridor (HP:0010307)1.83843657
99Radial bowing (HP:0002986)1.81003132
100Loss of speech (HP:0002371)1.80735323
101Bowing of the arm (HP:0006488)1.79398775
102Bowed forearm bones (HP:0003956)1.79398775
103Advanced eruption of teeth (HP:0006288)1.79393970
104Abnormality of the distal phalanges of the toes (HP:0010182)1.78170729
105Abnormal ossification of hand bones (HP:0005921)1.78109334
106Abnormality of carpal bone ossification (HP:0006257)1.77320290
107Fibroma (HP:0010614)1.76543972
108Buphthalmos (HP:0000557)1.75690016
109Intrahepatic cholestasis (HP:0001406)1.75580433
110Ovoid vertebral bodies (HP:0003300)1.73661563
111Asymmetric septal hypertrophy (HP:0001670)1.73061978
112High pitched voice (HP:0001620)1.72028357
113Follicular hyperkeratosis (HP:0007502)1.71555623
114Supranuclear gaze palsy (HP:0000605)1.71469737
115Ankyloglossia (HP:0010296)1.71446154
116Generalized amyotrophy (HP:0003700)1.71370059
117Urinary glycosaminoglycan excretion (HP:0003541)1.71159105
118Mucopolysacchariduria (HP:0008155)1.71159105
119Abnormality of the thoracic spine (HP:0100711)1.69606980
120Flat cornea (HP:0007720)1.69365311
121Abnormality of oral frenula (HP:0000190)1.68358802
122Disproportionate tall stature (HP:0001519)1.68108206
123Fibrous tissue neoplasm (HP:0012316)1.67677076
124Ependymoma (HP:0002888)1.67457326
125Exostoses (HP:0100777)1.67113492
126Abnormality of the common coagulation pathway (HP:0010990)1.66149444
127Axonal loss (HP:0003447)1.65154765
128Cortical dysplasia (HP:0002539)1.64941234
129* Pointed chin (HP:0000307)1.64031587
130Premature skin wrinkling (HP:0100678)1.63910471
131Amyloidosis (HP:0011034)1.63518885
132Global brain atrophy (HP:0002283)1.63517726
133Difficulty climbing stairs (HP:0003551)1.63433197
134Hepatocellular carcinoma (HP:0001402)1.62720788
135Metaphyseal cupping (HP:0003021)1.62402517
136Polygenic inheritance (HP:0010982)1.60926549
137Abnormality of the 4th metacarpal (HP:0010012)1.60682901
138Frequent falls (HP:0002359)1.59507761
139Increased connective tissue (HP:0009025)1.58803358
140Visceral angiomatosis (HP:0100761)1.58203421
141Increased nuchal translucency (HP:0010880)1.57868898
142Polycythemia (HP:0001901)1.57817819
143Esophageal varix (HP:0002040)1.57659245
144Severe short stature (HP:0003510)1.55067239
145Gastrointestinal carcinoma (HP:0002672)1.54760485
146Malignant gastrointestinal tract tumors (HP:0006749)1.54760485
147Increased cerebral lipofuscin (HP:0011813)1.54702215
148Abnormality of mucopolysaccharide metabolism (HP:0011020)1.54612399
149Abnormality of polysaccharide metabolism (HP:0011012)1.54612399
150Abnormality of glycosaminoglycan metabolism (HP:0004371)1.54612399
151Blue sclerae (HP:0000592)1.54115734
152Osteolytic defects of the hand bones (HP:0009699)1.53587999
153Osteolytic defects of the phalanges of the hand (HP:0009771)1.53587999
154Hemangiomatosis (HP:0007461)1.52563686
155Camptodactyly of toe (HP:0001836)1.52506463
156Short 4th metacarpal (HP:0010044)1.52347217
157Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.52347217

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.32271590
2PKN24.23486035
3EEF2K3.36523150
4ERN12.66000467
5MAP3K102.63635298
6PTK62.53791012
7SMG12.52280835
8PRPF4B2.45200528
9RIPK12.42241951
10PDGFRA2.13183794
11SIK11.97666350
12IRAK31.96775106
13TTN1.96527976
14SCYL21.96205957
15LRRK21.74030740
16CDK121.73187634
17MST1R1.67919758
18ICK1.65527701
19ALK1.55868109
20FGFR41.55431481
21NME21.51228572
22DDR21.50431773
23TYRO31.49378933
24TESK21.48840027
25KSR21.40837583
26CAMKK11.39061544
27PAK41.38858704
28PRKD31.38738289
29BMX1.37465462
30PRKD21.36339097
31LATS11.31749666
32RET1.30369119
33MAP3K131.27228096
34NEK11.25724602
35ARAF1.22438702
36CDK61.21777985
37CAMK1D1.21326508
38MAP3K31.19827045
39MAP3K91.19443674
40NEK21.19309343
41MTOR1.16495553
42STK31.14831326
43FLT31.13725043
44STK101.12298101
45CAMK1G1.10775280
46PTK21.09886848
47MARK21.09806275
48LATS20.99356266
49MAP3K60.98742256
50PAK20.98015052
51LMTK20.95516015
52TAOK20.93649404
53PIM20.93528469
54MAP2K30.93188945
55EPHB10.89919848
56LIMK10.88798477
57FGFR30.88729540
58MOS0.82683181
59MAP3K70.82390764
60TESK10.80757865
61MAP3K110.80432404
62PAK60.79721762
63DYRK1B0.79336476
64MAP3K20.78977999
65NEK90.77984701
66PDGFRB0.77669392
67JAK10.77576819
68MAP3K80.77275371
69PRKCH0.76743270
70GRK60.76093730
71FGFR10.74203799
72FGFR20.73172096
73NTRK10.72361042
74PASK0.71331687
75JAK20.70537372
76TAOK10.70220256
77FER0.69171768
78CDK40.65074941
79TAOK30.63962557
80JAK30.62898629
81STK380.61008895
82TYK20.60588104
83TGFBR20.58888897
84SIK20.58166553
85EPHA20.56089310
86RPS6KL10.55927638
87RPS6KC10.55927638
88RPS6KB20.55577829
89MAP2K20.54692913
90PDK30.54199146
91PDK40.54199146
92MAPK70.53145659
93MAPK150.52642516
94SIK30.52041973
95KSR10.51745402
96DAPK20.50738813
97TBK10.49398669
98FRK0.48412498
99MAP4K10.48210028
100EPHB20.47749937
101SGK30.47500889
102MAP3K140.47180811
103DMPK0.47036124
104PRKG20.46924789
105PDK10.45938223
106PAK30.45095083
107CSF1R0.44743259
108MAP2K10.44334961
109BLK0.44100415
110MAPKAPK30.44007399
111ZAP700.43841744
112BCKDK0.41178954
113RPS6KA20.40207506
114PRKD10.40161914
115MATK0.39778114
116ERBB20.39503951
117TNK20.39180749
118PDPK10.38905372
119IRAK20.38520202
120ERBB40.38434299
121MAPK120.38029750
122TTK0.36707145
123ROCK20.36382948
124ILK0.36342086
125PRKAA10.35801936
126CDC42BPA0.35669146
127RPS6KA60.34334781
128MAPK110.34180046
129CDK70.33397170
130MAP3K10.32979556
131MET0.32949264
132CSK0.32789387
133GSK3A0.32512908
134RPS6KA10.32293682
135HIPK20.32033723

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.96644873
2Nitrogen metabolism_Homo sapiens_hsa009103.56956909
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.54095849
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.25821937
5Arginine biosynthesis_Homo sapiens_hsa002201.91037784
6Fructose and mannose metabolism_Homo sapiens_hsa000511.71411355
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.64082136
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56060605
9Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.55906898
10Lysine degradation_Homo sapiens_hsa003101.55785924
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.55417971
12Galactose metabolism_Homo sapiens_hsa000521.54703088
13mTOR signaling pathway_Homo sapiens_hsa041501.53542130
14Prion diseases_Homo sapiens_hsa050201.52880300
15Chronic myeloid leukemia_Homo sapiens_hsa052201.52573998
16Bile secretion_Homo sapiens_hsa049761.49444771
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.37606699
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.32771890
19PPAR signaling pathway_Homo sapiens_hsa033201.26969475
20Fatty acid degradation_Homo sapiens_hsa000711.25515013
21Insulin resistance_Homo sapiens_hsa049311.25077373
22Selenocompound metabolism_Homo sapiens_hsa004501.22819962
23Vibrio cholerae infection_Homo sapiens_hsa051101.22357656
24Central carbon metabolism in cancer_Homo sapiens_hsa052301.20194324
25Proteoglycans in cancer_Homo sapiens_hsa052051.19171229
26Carbohydrate digestion and absorption_Homo sapiens_hsa049731.15558440
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12264934
28Small cell lung cancer_Homo sapiens_hsa052221.11724872
29Focal adhesion_Homo sapiens_hsa045101.11671962
30Biosynthesis of amino acids_Homo sapiens_hsa012301.11205563
31Endometrial cancer_Homo sapiens_hsa052131.10305312
32Tryptophan metabolism_Homo sapiens_hsa003801.10274346
33Non-small cell lung cancer_Homo sapiens_hsa052231.10013450
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09176838
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08110416
36* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07830696
37Fat digestion and absorption_Homo sapiens_hsa049751.05762228
38Glioma_Homo sapiens_hsa052141.04599954
39Adipocytokine signaling pathway_Homo sapiens_hsa049201.04330815
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.03932608
41Caffeine metabolism_Homo sapiens_hsa002321.03884285
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03104177
43Fatty acid metabolism_Homo sapiens_hsa012121.02491999
44Bladder cancer_Homo sapiens_hsa052191.00864723
45Complement and coagulation cascades_Homo sapiens_hsa046101.00390787
46Type II diabetes mellitus_Homo sapiens_hsa049300.97400941
47Fatty acid biosynthesis_Homo sapiens_hsa000610.96629911
48ErbB signaling pathway_Homo sapiens_hsa040120.96453771
49Neurotrophin signaling pathway_Homo sapiens_hsa047220.95327381
50Insulin signaling pathway_Homo sapiens_hsa049100.92927686
51AMPK signaling pathway_Homo sapiens_hsa041520.92867152
52Thyroid cancer_Homo sapiens_hsa052160.91429233
53GnRH signaling pathway_Homo sapiens_hsa049120.91363860
54Estrogen signaling pathway_Homo sapiens_hsa049150.90787482
55VEGF signaling pathway_Homo sapiens_hsa043700.90759284
56Hepatitis C_Homo sapiens_hsa051600.90454702
57Pancreatic cancer_Homo sapiens_hsa052120.89204567
58* N-Glycan biosynthesis_Homo sapiens_hsa005100.86902024
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86233768
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86051982
61Adherens junction_Homo sapiens_hsa045200.85509468
62Choline metabolism in cancer_Homo sapiens_hsa052310.84923299
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84276631
64Sulfur relay system_Homo sapiens_hsa041220.83074235
65Amoebiasis_Homo sapiens_hsa051460.82269273
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81885875
67Shigellosis_Homo sapiens_hsa051310.81622403
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81344494
69Glucagon signaling pathway_Homo sapiens_hsa049220.81177267
70Hippo signaling pathway_Homo sapiens_hsa043900.80647578
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79910417
72Carbon metabolism_Homo sapiens_hsa012000.78641839
73Inositol phosphate metabolism_Homo sapiens_hsa005620.77368564
74ECM-receptor interaction_Homo sapiens_hsa045120.77338424
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77138736
76Apoptosis_Homo sapiens_hsa042100.76555038
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76130767
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76062218
79TNF signaling pathway_Homo sapiens_hsa046680.74688717
80Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74328855
81MicroRNAs in cancer_Homo sapiens_hsa052060.74008946
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.73170638
83Colorectal cancer_Homo sapiens_hsa052100.72793216
84Dorso-ventral axis formation_Homo sapiens_hsa043200.72727946
85Salmonella infection_Homo sapiens_hsa051320.72712645
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72705987
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.72382090
88Hepatitis B_Homo sapiens_hsa051610.72364478
89Sphingolipid metabolism_Homo sapiens_hsa006000.71890787
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71429465
91Prolactin signaling pathway_Homo sapiens_hsa049170.70075496
92B cell receptor signaling pathway_Homo sapiens_hsa046620.70057632
93Acute myeloid leukemia_Homo sapiens_hsa052210.69920988
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69690418
95Protein digestion and absorption_Homo sapiens_hsa049740.69322899
96Glycerolipid metabolism_Homo sapiens_hsa005610.68452169
97Notch signaling pathway_Homo sapiens_hsa043300.67372091
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66914650
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66835034
100ABC transporters_Homo sapiens_hsa020100.65444130
101Toxoplasmosis_Homo sapiens_hsa051450.64825161
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.64262438
103Prostate cancer_Homo sapiens_hsa052150.62541204
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61508938
105Pertussis_Homo sapiens_hsa051330.59609102
106Renal cell carcinoma_Homo sapiens_hsa052110.59213146
107Staphylococcus aureus infection_Homo sapiens_hsa051500.59207385
108Platelet activation_Homo sapiens_hsa046110.58932465
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58503939
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58010309
111Antigen processing and presentation_Homo sapiens_hsa046120.57727897
112Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57553331
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57293775
114Viral carcinogenesis_Homo sapiens_hsa052030.56956174
115Lysosome_Homo sapiens_hsa041420.56937143
116Thyroid hormone synthesis_Homo sapiens_hsa049180.56828971
117PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55981152
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55276814
119Starch and sucrose metabolism_Homo sapiens_hsa005000.55073329
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54175453
121Endocytosis_Homo sapiens_hsa041440.53911452
122Dilated cardiomyopathy_Homo sapiens_hsa054140.53833748
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53266621
124Rap1 signaling pathway_Homo sapiens_hsa040150.53170283
125Axon guidance_Homo sapiens_hsa043600.52539264
126Phagosome_Homo sapiens_hsa041450.51025810
127Pathways in cancer_Homo sapiens_hsa052000.50189817
128One carbon pool by folate_Homo sapiens_hsa006700.48599269
129Basal cell carcinoma_Homo sapiens_hsa052170.47606356
130Pentose phosphate pathway_Homo sapiens_hsa000300.47001362
131HIF-1 signaling pathway_Homo sapiens_hsa040660.46980358
132Osteoclast differentiation_Homo sapiens_hsa043800.46631767
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46446973
134Pyruvate metabolism_Homo sapiens_hsa006200.46305572
135Malaria_Homo sapiens_hsa051440.45911540
136Butanoate metabolism_Homo sapiens_hsa006500.44889624
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.44721232
138Influenza A_Homo sapiens_hsa051640.44004742
139HTLV-I infection_Homo sapiens_hsa051660.43713076

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »