MAN2A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.46023566
2L-phenylalanine catabolic process (GO:0006559)5.46023566
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.21643157
4L-phenylalanine metabolic process (GO:0006558)5.21643157
5complement activation, alternative pathway (GO:0006957)5.21473146
6phospholipid scrambling (GO:0017121)4.98547260
7peptidyl-glutamic acid carboxylation (GO:0017187)4.94423411
8protein carboxylation (GO:0018214)4.94423411
9aromatic amino acid family catabolic process (GO:0009074)4.93811033
10negative regulation of fibrinolysis (GO:0051918)4.93056569
11negative regulation of neurotransmitter secretion (GO:0046929)4.91776991
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.90451383
13regulation of protein activation cascade (GO:2000257)4.85711185
14urea cycle (GO:0000050)4.85589308
15urea metabolic process (GO:0019627)4.85589308
16alpha-linolenic acid metabolic process (GO:0036109)4.81888058
17sulfur amino acid catabolic process (GO:0000098)4.68698623
18regulation of complement activation (GO:0030449)4.66074830
19kynurenine metabolic process (GO:0070189)4.52932470
20indole-containing compound catabolic process (GO:0042436)4.50318643
21indolalkylamine catabolic process (GO:0046218)4.50318643
22tryptophan catabolic process (GO:0006569)4.50318643
23regulation of fibrinolysis (GO:0051917)4.46444523
24cysteine metabolic process (GO:0006534)4.45488208
25high-density lipoprotein particle remodeling (GO:0034375)4.43812341
26homocysteine metabolic process (GO:0050667)4.42907201
27bile acid biosynthetic process (GO:0006699)4.38692139
28tryptophan metabolic process (GO:0006568)4.36657164
29nitrogen cycle metabolic process (GO:0071941)4.35069244
30glyoxylate metabolic process (GO:0046487)4.18896724
31nuclear pore complex assembly (GO:0051292)4.16443380
32reverse cholesterol transport (GO:0043691)4.14138396
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.12798867
34negative regulation of cholesterol transport (GO:0032375)4.04017362
35negative regulation of sterol transport (GO:0032372)4.04017362
36hemidesmosome assembly (GO:0031581)3.95871767
37cell adhesion mediated by integrin (GO:0033627)3.95432013
38regulation of triglyceride catabolic process (GO:0010896)3.94821903
39hormone catabolic process (GO:0042447)3.90064875
40lysine catabolic process (GO:0006554)3.90010125
41lysine metabolic process (GO:0006553)3.90010125
42serine family amino acid catabolic process (GO:0009071)3.89991028
43plasma lipoprotein particle clearance (GO:0034381)3.89706121
44very-low-density lipoprotein particle assembly (GO:0034379)3.85079229
45bile acid metabolic process (GO:0008206)3.81638392
46protein-lipid complex remodeling (GO:0034368)3.80025210
47macromolecular complex remodeling (GO:0034367)3.80025210
48plasma lipoprotein particle remodeling (GO:0034369)3.80025210
49positive regulation of fatty acid beta-oxidation (GO:0032000)3.73290810
50phospholipid efflux (GO:0033700)3.69409574
51tyrosine metabolic process (GO:0006570)3.66920504
52cellular modified amino acid catabolic process (GO:0042219)3.66811251
53amino-acid betaine metabolic process (GO:0006577)3.56676398
54fibrinolysis (GO:0042730)3.55888594
55regulation of apoptotic cell clearance (GO:2000425)3.54446755
56phospholipid homeostasis (GO:0055091)3.53613214
57aromatic amino acid family metabolic process (GO:0009072)3.51715306
58regulation of membrane lipid distribution (GO:0097035)3.51119739
59regulation of cholesterol homeostasis (GO:2000188)3.49936704
60acylglycerol homeostasis (GO:0055090)3.48709606
61triglyceride homeostasis (GO:0070328)3.48709606
62complement activation (GO:0006956)3.48568155
63bile acid and bile salt transport (GO:0015721)3.48116588
64cholesterol efflux (GO:0033344)3.48001906
65valine metabolic process (GO:0006573)3.45849832
66positive regulation of lipid catabolic process (GO:0050996)3.44407545
67embryonic process involved in female pregnancy (GO:0060136)3.42213295
68alpha-amino acid catabolic process (GO:1901606)3.40716009
69cellular glucuronidation (GO:0052695)3.39488888
70nuclear pore organization (GO:0006999)3.38859408
71ethanol oxidation (GO:0006069)3.38470203
72peptide catabolic process (GO:0043171)3.37962973
73COPII vesicle coating (GO:0048208)3.37741816
74complement activation, classical pathway (GO:0006958)3.37431341
75lipid translocation (GO:0034204)3.35423973
76phospholipid translocation (GO:0045332)3.35423973
77regulation of fatty acid beta-oxidation (GO:0031998)3.34388762
78lipoprotein metabolic process (GO:0042157)3.33742520
79endodermal cell differentiation (GO:0035987)3.31781887
80regulation of cholesterol esterification (GO:0010872)3.30845551
81plasma lipoprotein particle assembly (GO:0034377)3.30592737
82epoxygenase P450 pathway (GO:0019373)3.29668178
83glycine metabolic process (GO:0006544)3.29231167
84protein activation cascade (GO:0072376)3.21928929
85protein-lipid complex assembly (GO:0065005)3.21602765
86low-density lipoprotein particle clearance (GO:0034383)3.21438492
87negative regulation of digestive system process (GO:0060457)3.21000030
88cell-substrate junction assembly (GO:0007044)3.20549566
89dicarboxylic acid biosynthetic process (GO:0043650)3.20086667
90cellular amino acid catabolic process (GO:0009063)3.19530670
91pathway-restricted SMAD protein phosphorylation (GO:0060389)3.19343786
92apoptotic cell clearance (GO:0043277)3.15880992
93serine family amino acid metabolic process (GO:0009069)3.14264870
942-oxoglutarate metabolic process (GO:0006103)3.13914919
95glutamate metabolic process (GO:0006536)3.13695012
96indolalkylamine metabolic process (GO:0006586)3.12249779
97benzene-containing compound metabolic process (GO:0042537)3.12170903
98intestinal cholesterol absorption (GO:0030299)3.11522139
99sterol homeostasis (GO:0055092)3.11179989
100cholesterol homeostasis (GO:0042632)3.10828997
101acute-phase response (GO:0006953)3.10444327
102mesodermal cell differentiation (GO:0048333)3.08758312
103positive regulation of hemostasis (GO:1900048)3.07653603
104positive regulation of blood coagulation (GO:0030194)3.07653603
105skin morphogenesis (GO:0043589)3.06542644
106regulation of plasminogen activation (GO:0010755)3.06228814
107coenzyme catabolic process (GO:0009109)3.05349587
108hypotonic response (GO:0006971)3.04833442
109opsonization (GO:0008228)3.04764113
110plasma lipoprotein particle organization (GO:0071827)3.03203449
111regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.03122812
112intestinal epithelial cell development (GO:0060576)3.01618120
113protein-lipid complex subunit organization (GO:0071825)2.99750516
114negative regulation of protein activation cascade (GO:2000258)2.99025318
115uronic acid metabolic process (GO:0006063)2.95884677
116glucuronate metabolic process (GO:0019585)2.95884677
117positive regulation of coagulation (GO:0050820)2.95064633
118positive regulation of fatty acid oxidation (GO:0046321)2.93829189
119negative regulation of lipase activity (GO:0060192)2.91501283
120serine family amino acid biosynthetic process (GO:0009070)2.89828455
121UDP-N-acetylglucosamine metabolic process (GO:0006047)2.88622203
122negative regulation of DNA repair (GO:0045738)2.88066993
123imidazole-containing compound metabolic process (GO:0052803)2.86584495
124drug catabolic process (GO:0042737)2.85849075
125low-density lipoprotein particle remodeling (GO:0034374)2.84072266
126cytolysis (GO:0019835)2.83814614
127drinking behavior (GO:0042756)2.82835387
128chondrocyte proliferation (GO:0035988)2.79867643
129COPI coating of Golgi vesicle (GO:0048205)2.79826432
130Golgi transport vesicle coating (GO:0048200)2.79826432
131nucleotide-sugar biosynthetic process (GO:0009226)2.79051516
132pore complex assembly (GO:0046931)2.78625822
133regulation of transforming growth factor beta2 production (GO:0032909)2.75763207
134bundle of His cell to Purkinje myocyte communication (GO:0086069)2.74918336
135regulation of bile acid biosynthetic process (GO:0070857)2.73645071
136intestinal absorption (GO:0050892)2.72432256
137maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.70952509
138gap junction assembly (GO:0016264)2.64866464
139positive regulation of endothelial cell apoptotic process (GO:2000353)2.64785617
140negative regulation of protein tyrosine kinase activity (GO:0061099)2.63564767
141midgut development (GO:0007494)2.61366032
142cell-substrate adherens junction assembly (GO:0007045)2.61356663
143focal adhesion assembly (GO:0048041)2.61356663
144protein retention in ER lumen (GO:0006621)2.57920122
145paraxial mesoderm development (GO:0048339)2.55983006
146negative regulation of neurotransmitter transport (GO:0051589)2.53444082
147glomerular visceral epithelial cell development (GO:0072015)2.50431672
148anterior/posterior axis specification, embryo (GO:0008595)2.50139769
149positive regulation of osteoblast proliferation (GO:0033690)2.48921278
150regulation of transforming growth factor beta1 production (GO:0032908)2.48752983
151early endosome to late endosome transport (GO:0045022)2.47169378
152negative regulation of complement activation (GO:0045916)2.43720809
153pre-miRNA processing (GO:0031054)2.43579357
154negative regulation of fatty acid transport (GO:2000192)2.42859418
155substrate adhesion-dependent cell spreading (GO:0034446)2.40914843
156regulation of extracellular matrix disassembly (GO:0010715)2.39511433
157positive regulation of SMAD protein import into nucleus (GO:0060391)2.39185852
158negative regulation of fibroblast apoptotic process (GO:2000270)2.37810256
159embryonic retina morphogenesis in camera-type eye (GO:0060059)2.35910765
160adherens junction assembly (GO:0034333)2.34867150
161lipoprotein transport (GO:0042953)2.33014107
162regulation of osteoblast proliferation (GO:0033688)2.32775042
163desmosome organization (GO:0002934)2.32288252
164negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.31411995
165negative regulation of protein localization to plasma membrane (GO:1903077)2.31067856
166negative regulation of lipid transport (GO:0032369)2.29914838
167vesicle coating (GO:0006901)2.29695350
168positive regulation of catecholamine secretion (GO:0033605)2.26557522
169regulation of transforming growth factor beta production (GO:0071634)2.25369272
170negative regulation of keratinocyte proliferation (GO:0010839)2.25112493
171negative regulation of activin receptor signaling pathway (GO:0032926)2.24008698
172positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.22986152
173negative regulation of anoikis (GO:2000811)2.22973369
174ribosome assembly (GO:0042255)2.21192340

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.66003504
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.18006094
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.48339110
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.08691472
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.51875030
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.86691612
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.51402359
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.30627313
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.15050089
10CLOCK_20551151_ChIP-Seq_293T_Human2.83378650
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.66485628
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.65457758
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.63242433
14E2F7_22180533_ChIP-Seq_HELA_Human2.49364109
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.33499330
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.27011670
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07703083
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.06299593
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03519053
20CDX2_19796622_ChIP-Seq_MESCs_Mouse2.00615560
21SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.97600925
22* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.90764595
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.88740406
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85561407
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.83257123
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.79642087
27* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.76928908
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.70863853
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.70857890
30* FOXA2_19822575_ChIP-Seq_HepG2_Human1.70799824
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.69486188
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.68315182
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.67621966
34PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.66577853
35TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.65871254
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64920033
37GATA1_22025678_ChIP-Seq_K562_Human1.63996371
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.63945729
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.61466602
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57693036
41TCF4_18268006_ChIP-ChIP_LS174T_Human1.57419643
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.55905094
43* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.52923535
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.52618938
45FOXM1_26456572_ChIP-Seq_MCF-7_Human1.51075738
46CTNNB1_20460455_ChIP-Seq_HCT116_Human1.46719898
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44674654
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.43726222
49EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.41349355
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39596239
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.33374418
52PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31903862
53SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31573255
54SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29848714
55* TP63_23658742_ChIP-Seq_EP156T_Human1.29749487
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.28493922
57GATA4_25053715_ChIP-Seq_YYC3_Human1.28349429
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.28078937
59TP53_16413492_ChIP-PET_HCT116_Human1.27805813
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27643819
61PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.27474226
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26590048
63HNF4A_19822575_ChIP-Seq_HepG2_Human1.24723413
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21324077
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19222273
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15628046
67* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15267224
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14296148
69GATA6_25053715_ChIP-Seq_YYC3_Human1.12699451
70STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.12109813
71ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12018388
72TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10265330
73TP53_18474530_ChIP-ChIP_U2OS_Human1.09627783
74* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09354108
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09283408
76AHR_22903824_ChIP-Seq_MCF-7_Human1.08619372
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08501071
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08248169
79RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07535282
80* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06912080
81ZNF263_19887448_ChIP-Seq_K562_Human1.05744797
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05026959
83* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04975629
84SOX2_20726797_ChIP-Seq_SW620_Human1.04606289
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03703951
86* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03681167
87* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03681167
88IRF8_21731497_ChIP-ChIP_J774_Mouse1.01846800
89FOXM1_23109430_ChIP-Seq_U2OS_Human1.01646843
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.01112802
91CJUN_26792858_Chip-Seq_BT549_Human1.00994736
92AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00886358
93ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00821305
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.00521343
95CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99415619
96HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99193823
97SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98803553
98SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98803553
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98175926
100PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98063361
101PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97929533
102* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97813014
103GATA2_21666600_ChIP-Seq_HMVEC_Human0.96823922
104* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95726522
105TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95312560
106* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94821035
107ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.94446508
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94146814
109CDX2_20551321_ChIP-Seq_CACO-2_Human0.93984600
110TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93785444
111TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93191932
112ELK3_25401928_ChIP-Seq_HUVEC_Human0.92939282
113PIAS1_25552417_ChIP-Seq_VCAP_Human0.92757774
114EZH2_27294783_Chip-Seq_NPCs_Mouse0.92502097
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92244134
116SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90181463
117PU_27001747_Chip-Seq_BMDM_Mouse0.89576677
118POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89239507
119ESR1_20079471_ChIP-ChIP_T-47D_Human0.87949671
120ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87073530
121P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86046733
122RACK7_27058665_Chip-Seq_MCF-7_Human0.85538210
123ATF3_27146783_Chip-Seq_COLON_Human0.84301836
124FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82277154
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80849393
126TBX20_22328084_ChIP-Seq_HEART_Mouse0.80576472
127TBX20_22080862_ChIP-Seq_HEART_Mouse0.80576472
128FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.79794760
129* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.78654813
130TCF7_22412390_ChIP-Seq_EML_Mouse0.77710424
131AR_21909140_ChIP-Seq_LNCAP_Human0.77483161
132FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77396581
133* BRD4_25478319_ChIP-Seq_HGPS_Human0.77150315
134ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76985988
135RUNX_20019798_ChIP-Seq_JUKART_Human0.76717125
136* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.76563472
137* GATA2_19941826_ChIP-Seq_K562_Human0.76458087
138NFIB_24661679_ChIP-Seq_LUNG_Mouse0.75498576
139FOXA1_25552417_ChIP-Seq_VCAP_Human0.74617416
140PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73580012
141SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.72775270
142* GATA3_24758297_ChIP-Seq_MCF-7_Human0.72364932
143GATA1_19941826_ChIP-Seq_K562_Human0.71671123
144VDR_24787735_ChIP-Seq_THP-1_Human0.71668050

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.92009276
2MP0005360_urolithiasis5.48322123
3MP0005365_abnormal_bile_salt4.51672616
4MP0005085_abnormal_gallbladder_physiolo4.36305553
5MP0008875_abnormal_xenobiotic_pharmacok3.40552980
6MP0003252_abnormal_bile_duct3.34175736
7MP0003705_abnormal_hypodermis_morpholog3.16920431
8MP0003941_abnormal_skin_development3.03190240
9MP0008438_abnormal_cutaneous_collagen2.96195136
10MP0010329_abnormal_lipoprotein_level2.69068882
11MP0008057_abnormal_DNA_replication2.54717700
12MP0009840_abnormal_foam_cell2.44083639
13MP0005083_abnormal_biliary_tract2.33247718
14MP0003806_abnormal_nucleotide_metabolis2.33136171
15MP0005409_darkened_coat_color2.30435649
16MP0001666_abnormal_nutrient_absorption2.29356821
17MP0003300_gastrointestinal_ulcer2.20380417
18MP0002877_abnormal_melanocyte_morpholog2.11195468
19MP0003191_abnormal_cellular_cholesterol2.05206932
20MP0005332_abnormal_amino_acid2.01778703
21MP0003950_abnormal_plasma_membrane2.01718360
22MP0003195_calcinosis1.93850589
23* MP0000609_abnormal_liver_physiology1.83767512
24MP0005275_abnormal_skin_tensile1.82873568
25MP0005257_abnormal_intraocular_pressure1.78820648
26MP0002138_abnormal_hepatobiliary_system1.73062293
27MP0010234_abnormal_vibrissa_follicle1.72119063
28MP0002009_preneoplasia1.65315260
29MP0003868_abnormal_feces_composition1.53267029
30MP0002118_abnormal_lipid_homeostasis1.51852276
31MP0005319_abnormal_enzyme/_coenzyme1.50972112
32MP0002166_altered_tumor_susceptibility1.45032878
33MP0004019_abnormal_vitamin_homeostasis1.41547177
34MP0010352_gastrointestinal_tract_polyps1.41168174
35MP0003566_abnormal_cell_adhesion1.30888392
36MP0005023_abnormal_wound_healing1.30549967
37MP0003890_abnormal_embryonic-extraembry1.29908422
38MP0000428_abnormal_craniofacial_morphol1.29791603
39MP0000762_abnormal_tongue_morphology1.28750761
40MP0010678_abnormal_skin_adnexa1.26512907
41MP0001849_ear_inflammation1.26263162
42* MP0002396_abnormal_hematopoietic_system1.25850235
43MP0002086_abnormal_extraembryonic_tissu1.22198012
44MP0006054_spinal_hemorrhage1.22104111
45* MP0009643_abnormal_urine_homeostasis1.19659412
46MP0002254_reproductive_system_inflammat1.19587412
47MP0009764_decreased_sensitivity_to1.19014732
48MP0005058_abnormal_lysosome_morphology1.18369987
49MP0004957_abnormal_blastocyst_morpholog1.17864971
50MP0004782_abnormal_surfactant_physiolog1.17508649
51MP0010368_abnormal_lymphatic_system1.17446156
52MP0002060_abnormal_skin_morphology1.15717458
53* MP0000598_abnormal_liver_morphology1.15463291
54MP0003436_decreased_susceptibility_to1.15392401
55MP0000678_abnormal_parathyroid_gland1.13190849
56MP0005647_abnormal_sex_gland1.11819256
57MP0009384_cardiac_valve_regurgitation1.09014885
58MP0009780_abnormal_chondrocyte_physiolo1.08242016
59MP0005220_abnormal_exocrine_pancreas1.06874214
60MP0000920_abnormal_myelination1.05334838
61MP0004947_skin_inflammation1.04629357
62MP0002089_abnormal_postnatal_growth/wei1.04073480
63MP0000462_abnormal_digestive_system1.01631842
64MP0008961_abnormal_basal_metabolism1.01036601
65MP0000013_abnormal_adipose_tissue1.00540596
66MP0005584_abnormal_enzyme/coenzyme_acti1.00466454
67MP0000432_abnormal_head_morphology0.99634619
68MP0000383_abnormal_hair_follicle0.98873760
69MP0003828_pulmonary_edema0.98366458
70MP0009763_increased_sensitivity_to0.96897475
71MP0003329_amyloid_beta_deposits0.96531334
72MP0004272_abnormal_basement_membrane0.95916827
73MP0005621_abnormal_cell_physiology0.95870940
74MP0005076_abnormal_cell_differentiation0.95641621
75MP0009053_abnormal_anal_canal0.95025518
76MP0005503_abnormal_tendon_morphology0.94738398
77MP0005408_hypopigmentation0.94702852
78MP0005670_abnormal_white_adipose0.93979858
79MP0003984_embryonic_growth_retardation0.93452840
80MP0001730_embryonic_growth_arrest0.93324086
81MP0001299_abnormal_eye_distance/0.92863190
82MP0002088_abnormal_embryonic_growth/wei0.92516492
83MP0002006_tumorigenesis0.92167733
84MP0008469_abnormal_protein_level0.91527191
85MP0005464_abnormal_platelet_physiology0.90750565
86MP0003279_aneurysm0.90721696
87MP0004233_abnormal_muscle_weight0.89972306
88MP0000604_amyloidosis0.89927044
89MP0002168_other_aberrant_phenotype0.88590020
90MP0005380_embryogenesis_phenotype0.87820382
91MP0001672_abnormal_embryogenesis/_devel0.87820382
92MP0002084_abnormal_developmental_patter0.87538661
93MP0004130_abnormal_muscle_cell0.86957845
94MP0003690_abnormal_glial_cell0.86502049
95MP0003448_altered_tumor_morphology0.86245321
96MP0004264_abnormal_extraembryonic_tissu0.85998931
97MP0001756_abnormal_urination0.85957211
98MP0003186_abnormal_redox_activity0.85756328
99MP0003453_abnormal_keratinocyte_physiol0.85388906
100MP0003091_abnormal_cell_migration0.84681875
101MP0000627_abnormal_mammary_gland0.84668425
102MP0001216_abnormal_epidermal_layer0.84619906
103MP0009672_abnormal_birth_weight0.83798710
104MP0001958_emphysema0.83523406
105MP0003303_peritoneal_inflammation0.83492670
106MP0002998_abnormal_bone_remodeling0.82594359
107MP0003935_abnormal_craniofacial_develop0.82500066
108MP0001533_abnormal_skeleton_physiology0.82134008
109MP0000490_abnormal_crypts_of0.81855537
110MP0004134_abnormal_chest_morphology0.81170303
111MP0010307_abnormal_tumor_latency0.81033488
112MP0008007_abnormal_cellular_replicative0.80030317
113MP0002925_abnormal_cardiovascular_devel0.79442984
114MP0001764_abnormal_homeostasis0.78210307
115MP0005623_abnormal_meninges_morphology0.77846339
116MP0005666_abnormal_adipose_tissue0.77722405
117* MP0002136_abnormal_kidney_physiology0.77552001
118MP0003724_increased_susceptibility_to0.77178832
119MP0003045_fibrosis0.76369306
120MP0001243_abnormal_dermal_layer0.76348401
121MP0000767_abnormal_smooth_muscle0.76140547
122MP0003632_abnormal_nervous_system0.75661168
123MP0001614_abnormal_blood_vessel0.75460054
124MP0008004_abnormal_stomach_pH0.75303740
125MP0000579_abnormal_nail_morphology0.74162424
126MP0003115_abnormal_respiratory_system0.73612567
127MP0003183_abnormal_peptide_metabolism0.72878845
128MP0004185_abnormal_adipocyte_glucose0.72078601
129MP0000477_abnormal_intestine_morphology0.72036561
130MP0002928_abnormal_bile_duct0.71324768
131MP0002295_abnormal_pulmonary_circulatio0.70863488
132MP0005451_abnormal_body_composition0.69107819
133MP0002896_abnormal_bone_mineralization0.68065527
134MP0001915_intracranial_hemorrhage0.68019573
135* MP0001845_abnormal_inflammatory_respons0.67504633
136MP0009642_abnormal_blood_homeostasis0.67497541
137MP0005636_abnormal_mineral_homeostasis0.67288267
138MP0000685_abnormal_immune_system0.67272149
139MP0009697_abnormal_copulation0.67171860
140MP0005334_abnormal_fat_pad0.66652178
141MP0001661_extended_life_span0.64003554
142MP0009765_abnormal_xenobiotic_induced0.63360307
143MP0005164_abnormal_response_to0.62445224
144MP0010155_abnormal_intestine_physiology0.62231259
145MP0000249_abnormal_blood_vessel0.61787604
146MP0002971_abnormal_brown_adipose0.60583248
147MP0001881_abnormal_mammary_gland0.59864726
148MP0001873_stomach_inflammation0.59199905
149MP0002419_abnormal_innate_immunity0.58290016
150MP0005166_decreased_susceptibility_to0.56349671
151* MP0002135_abnormal_kidney_morphology0.56219974
152MP0002796_impaired_skin_barrier0.53924680
153MP0003075_altered_response_to0.52807388
154MP0001835_abnormal_antigen_presentation0.51599097
155MP0002128_abnormal_blood_circulation0.51323074
156MP0009115_abnormal_fat_cell0.51119024

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.29033268
2Intrahepatic cholestasis (HP:0001406)5.21458828
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.01312211
4Xanthomatosis (HP:0000991)4.98960496
5Complement deficiency (HP:0004431)4.97274491
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.63094108
7Prolonged partial thromboplastin time (HP:0003645)4.57124580
8Hypobetalipoproteinemia (HP:0003563)4.38399685
9Abnormality of the common coagulation pathway (HP:0010990)4.36041781
10Abnormality of complement system (HP:0005339)3.91589898
11Hyperlipoproteinemia (HP:0010980)3.72282841
12Myocardial infarction (HP:0001658)3.68572698
13Joint hemorrhage (HP:0005261)3.66814529
14Abnormality of glutamine family amino acid metabolism (HP:0010902)3.58923217
15Hypolipoproteinemia (HP:0010981)3.58439792
16Epidermoid cyst (HP:0200040)3.55770508
17Abnormality of the intrinsic pathway (HP:0010989)3.43173821
18Flat acetabular roof (HP:0003180)3.40731664
19Hypoalphalipoproteinemia (HP:0003233)3.40570319
20Systemic lupus erythematosus (HP:0002725)3.36526185
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.32209763
22Arterial tortuosity (HP:0005116)3.31103026
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.29477975
24Fat malabsorption (HP:0002630)3.16869436
25Vascular tortuosity (HP:0004948)3.11025093
26Hyperammonemia (HP:0001987)3.11017507
27Papillary thyroid carcinoma (HP:0002895)2.95068176
28Ketosis (HP:0001946)2.94943414
29Atrophic scars (HP:0001075)2.92611238
30Protrusio acetabuli (HP:0003179)2.92203947
31Ankyloglossia (HP:0010296)2.91198930
32Peritonitis (HP:0002586)2.89964460
33Esophageal varix (HP:0002040)2.81900509
34Mitral stenosis (HP:0001718)2.77492994
35Glomerulonephritis (HP:0000099)2.76480148
36Hypercholesterolemia (HP:0003124)2.76476428
37Hypoglycemic coma (HP:0001325)2.72990463
38Hepatocellular carcinoma (HP:0001402)2.70741982
39Abnormality of aspartate family amino acid metabolism (HP:0010899)2.70396501
40Skin nodule (HP:0200036)2.65322225
41Hyperglycinuria (HP:0003108)2.61862336
42Abnormality of methionine metabolism (HP:0010901)2.61016382
43Recurrent gram-negative bacterial infections (HP:0005420)2.58997032
44Hyperglycinemia (HP:0002154)2.56859395
45Subacute progressive viral hepatitis (HP:0006572)2.56624230
46Abnormality of serine family amino acid metabolism (HP:0010894)2.55790194
47Abnormality of glycine metabolism (HP:0010895)2.55790194
48Abnormality of oral frenula (HP:0000190)2.50777442
49Abnormality of pyrimidine metabolism (HP:0004353)2.50712501
50Nephritis (HP:0000123)2.50644008
51Conjugated hyperbilirubinemia (HP:0002908)2.48548242
52Abnormal foot bone ossification (HP:0010675)2.47011296
53Spastic diplegia (HP:0001264)2.45782286
54Menorrhagia (HP:0000132)2.43122986
55Premature rupture of membranes (HP:0001788)2.39580160
56Abnormality of carpal bone ossification (HP:0006257)2.39193066
57Scanning speech (HP:0002168)2.37441500
58Aortic aneurysm (HP:0004942)2.35190914
59Wormian bones (HP:0002645)2.34560917
60Abnormality of nucleobase metabolism (HP:0010932)2.34197385
61Vertebral arch anomaly (HP:0008438)2.31165587
62Cardiovascular calcification (HP:0011915)2.29711993
63Steatorrhea (HP:0002570)2.29575791
64Relative macrocephaly (HP:0004482)2.29294023
65Vertebral compression fractures (HP:0002953)2.28648163
66Osteolytic defects of the phalanges of the hand (HP:0009771)2.26793479
67Osteolytic defects of the hand bones (HP:0009699)2.26793479
68Abnormality of purine metabolism (HP:0004352)2.25939828
69Cerebral aneurysm (HP:0004944)2.25547552
70Hemorrhage of the eye (HP:0011885)2.23014979
71Aortic dissection (HP:0002647)2.21827084
72Mitral valve prolapse (HP:0001634)2.21281321
73Abnormality of fatty-acid metabolism (HP:0004359)2.20197761
74Asymmetry of the thorax (HP:0001555)2.19890493
75Increased mean platelet volume (HP:0011877)2.17963800
76Spinal cord lesions (HP:0100561)2.15218192
77Syringomyelia (HP:0003396)2.15218192
78Spontaneous abortion (HP:0005268)2.14232645
79Hydroxyprolinuria (HP:0003080)2.13756576
80Abnormality of proline metabolism (HP:0010907)2.13756576
81Vascular calcification (HP:0004934)2.12831372
82Abnormality of the acetabulum (HP:0003170)2.12363969
83Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.12194718
84Abnormal ossification of hand bones (HP:0005921)2.09934935
85Gingival bleeding (HP:0000225)2.09817553
86Ketoacidosis (HP:0001993)2.09086254
87Cervical subluxation (HP:0003308)2.07493036
88Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.07098375
89Vertebral hypoplasia (HP:0008417)2.07098375
90Dilatation of the ascending aorta (HP:0005111)2.03267844
91Absent frontal sinuses (HP:0002688)2.00358940
92Abnormal tarsal ossification (HP:0008369)1.99607534
93Aneurysm (HP:0002617)1.98267268
94Hypophosphatemic rickets (HP:0004912)1.97079587
95Abnormal platelet volume (HP:0011876)1.95584223
96Acanthocytosis (HP:0001927)1.95216273
97Hyperbilirubinemia (HP:0002904)1.94974234
98Abnormal cartilage morphology (HP:0002763)1.94654442
99Broad metatarsal (HP:0001783)1.93895611
100Urinary glycosaminoglycan excretion (HP:0003541)1.93767074
101Mucopolysacchariduria (HP:0008155)1.93767074
102Fragile skin (HP:0001030)1.93094480
103Back pain (HP:0003418)1.89785299
104Thrombophlebitis (HP:0004418)1.88183897
105Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.87312657
106Ectopia lentis (HP:0001083)1.86922269
107Spinal rigidity (HP:0003306)1.86801074
108Selective tooth agenesis (HP:0001592)1.86164855
109Ankle contracture (HP:0006466)1.85983421
110Abnormality of the lumbar spine (HP:0100712)1.85946423
111Coronal craniosynostosis (HP:0004440)1.84804026
112Abnormal delivery (HP:0001787)1.84731228
113Abnormality of transition element cation homeostasis (HP:0011030)1.84054192
114Shallow orbits (HP:0000586)1.83388034
115Hematochezia (HP:0002573)1.82723001
116Cupped ribs (HP:0000887)1.82191096
117Abnormal hand bone ossification (HP:0010660)1.81936283
118Abnormality of the vasculature of the conjunctiva (HP:0008054)1.81442394
119Lymphangioma (HP:0100764)1.81394704
120Amyloidosis (HP:0011034)1.81054119
121Spondylolisthesis (HP:0003302)1.81003056
122Neonatal short-limb short stature (HP:0008921)1.80729228
123Delayed closure of the anterior fontanelle (HP:0001476)1.80435220
124Missing ribs (HP:0000921)1.78675086
125Overgrowth (HP:0001548)1.77294009
126Hypochromic microcytic anemia (HP:0004840)1.76074140
127Ulnar bowing (HP:0003031)1.75696455
128Tetraparesis (HP:0002273)1.75648639
129Blue sclerae (HP:0000592)1.75222629
130Pancreatitis (HP:0001733)1.73528174
131Abnormality of the Achilles tendon (HP:0005109)1.73509140
132Stroke (HP:0001297)1.72743915
133Abnormality of polysaccharide metabolism (HP:0011012)1.72671291
134Abnormality of glycosaminoglycan metabolism (HP:0004371)1.72671291
135Abnormality of mucopolysaccharide metabolism (HP:0011020)1.72671291
136Conjunctival telangiectasia (HP:0000524)1.72648070
137Sensorimotor neuropathy (HP:0007141)1.71813402
138Turricephaly (HP:0000262)1.71587796
139Abnormality of iron homeostasis (HP:0011031)1.69673368
140Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.68947872
141Alopecia of scalp (HP:0002293)1.68804687
142Coxa vara (HP:0002812)1.68003289
143Malnutrition (HP:0004395)1.67981610
144Right ventricular cardiomyopathy (HP:0011663)1.67448898
145Vacuolated lymphocytes (HP:0001922)1.66882407
146Soft skin (HP:0000977)1.66424157
147Hypoglycemic seizures (HP:0002173)1.65437349
148Thickened calvaria (HP:0002684)1.64581093
149Thoracolumbar scoliosis (HP:0002944)1.63558934
150Abnormality of the distal phalanx of the thumb (HP:0009617)1.63335544
151Abnormality of dentin (HP:0010299)1.62490054
152Rickets (HP:0002748)1.59706442
153Thyroid carcinoma (HP:0002890)1.59493011
154Advanced eruption of teeth (HP:0006288)1.58082046
155Fused cervical vertebrae (HP:0002949)1.57554011
156Joint laxity (HP:0001388)1.57417723
157Biconcave vertebral bodies (HP:0004586)1.57205436
158Malignant gastrointestinal tract tumors (HP:0006749)1.56645455
159Gastrointestinal carcinoma (HP:0002672)1.56645455

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.39545704
2EIF2AK33.46181740
3SIK13.45406803
4TRIB33.30483040
5LATS13.21524291
6FRK3.01485709
7PKN22.79328885
8TAOK32.76279609
9FGFR42.59709822
10BCKDK2.53737986
11MST1R2.29038716
12PRKG22.27466020
13TTN2.18317359
14PTK62.13769895
15RIPK11.97655744
16MAP3K101.83251235
17EEF2K1.78948417
18PBK1.78513290
19TYK21.68439313
20CAMK1D1.67719864
21PDGFRA1.65412996
22PRPF4B1.54892890
23BRSK21.53984536
24JAK11.50708022
25STK31.45547495
26TGFBR21.42904213
27INSRR1.40446564
28LRRK21.38477236
29NEK91.35101752
30EPHB11.34264311
31STK101.31055264
32FGFR31.29382452
33BMX1.26624890
34SCYL21.24369907
35FLT31.24248253
36ICK1.22055833
37MET1.21842601
38WNK11.19969151
39NTRK11.17357758
40CDK121.16449308
41CDK61.15748724
42DDR21.15722071
43FGFR21.15015226
44CAMK1G1.09313538
45STK381.09001419
46PIK3CG1.08976705
47STK38L1.07322706
48JAK31.06279872
49EPHA31.03067466
50TTK1.02880106
51MAP2K31.02832315
52LMTK21.02743405
53TBK11.01805517
54STK241.01261568
55YES10.99318858
56BRD40.99000051
57CSK0.97128928
58ERBB40.96046092
59JAK20.95755926
60MAP3K30.93672681
61PTK20.92643321
62NUAK10.91428333
63EPHA20.91250815
64KSR20.91162162
65MTOR0.91066470
66TRPM70.90893396
67STK390.90661542
68MAP3K140.90429704
69PAK20.85359906
70CSF1R0.83310253
71MAP3K70.83263616
72NLK0.81019101
73PDGFRB0.79870694
74SGK20.77565923
75MAPK110.77157579
76AKT30.75461683
77FER0.73182479
78SMG10.71406202
79MAP3K20.71307673
80EIF2AK20.69630005
81MAP3K10.69432467
82MAP4K10.68377758
83MYLK0.67886978
84GRK60.64252112
85KDR0.61505893
86RET0.59950281
87GSK3A0.57460154
88RPS6KB20.57417773
89FGFR10.57313599
90PRKAA20.57274104
91ZAP700.55265501
92CHUK0.54918071
93NEK60.52812285
94EGFR0.52502870
95RPS6KB10.52056819
96RPS6KA40.52012255
97CDK40.51685069
98PRKD20.51211330
99DYRK1B0.50248942
100ACVR1B0.49122588
101SGK30.47654053
102ERBB20.47106701
103MELK0.44989619
104DMPK0.44493008
105ERBB30.44170698
106ITK0.43659278
107IGF1R0.43065183
108TEC0.42885896
109PIK3CA0.41703477
110MAP2K10.41119481
111IKBKE0.40723480
112PRKCH0.40719608
113IRAK30.40175285
114MAP3K80.39955883
115PAK40.39734601
116ABL20.38719555
117LATS20.38719181
118TAF10.38297313
119SGK2230.37246207
120SGK4940.37246207
121HCK0.36090153
122ABL10.36009220
123INSR0.35742097
124MAPK70.35397184
125ALK0.34878126
126PDPK10.34547875
127TGFBR10.34389470
128IKBKB0.31681496
129KIT0.31645194
130PIM10.30446629
131EPHB20.30373738
132ROCK20.30232415
133MAP3K120.29634311
134MAP3K60.29501326
135STK40.29415429
136MST40.28868241
137CDK90.28504842
138BTK0.27493999
139PRKCQ0.26646626

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.96113326
2Nitrogen metabolism_Homo sapiens_hsa009103.77226903
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.30236635
4Complement and coagulation cascades_Homo sapiens_hsa046103.09427256
5Arginine biosynthesis_Homo sapiens_hsa002202.99200887
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.96637825
7Staphylococcus aureus infection_Homo sapiens_hsa051502.51006406
8Tryptophan metabolism_Homo sapiens_hsa003802.44457802
9Fatty acid degradation_Homo sapiens_hsa000712.38328822
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25355734
11Caffeine metabolism_Homo sapiens_hsa002322.17164159
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.09602349
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.08716469
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.04568126
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.98883509
16PPAR signaling pathway_Homo sapiens_hsa033201.97570450
17Thyroid cancer_Homo sapiens_hsa052161.66416454
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.65827596
19Peroxisome_Homo sapiens_hsa041461.65084186
20Fatty acid metabolism_Homo sapiens_hsa012121.64710031
21Propanoate metabolism_Homo sapiens_hsa006401.64372478
22Selenocompound metabolism_Homo sapiens_hsa004501.58342162
23Chemical carcinogenesis_Homo sapiens_hsa052041.58110641
24Histidine metabolism_Homo sapiens_hsa003401.54622691
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.52352076
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.49331753
27Bile secretion_Homo sapiens_hsa049761.42793044
28Butanoate metabolism_Homo sapiens_hsa006501.42336056
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40276365
30beta-Alanine metabolism_Homo sapiens_hsa004101.40099080
31Starch and sucrose metabolism_Homo sapiens_hsa005001.36625175
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.36532847
33Sulfur metabolism_Homo sapiens_hsa009201.34346324
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.32011007
35Fat digestion and absorption_Homo sapiens_hsa049751.30580507
36Retinol metabolism_Homo sapiens_hsa008301.28361275
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26361731
38ABC transporters_Homo sapiens_hsa020101.23360875
39Lysine degradation_Homo sapiens_hsa003101.20775686
40MicroRNAs in cancer_Homo sapiens_hsa052061.19954342
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.16021316
42Phenylalanine metabolism_Homo sapiens_hsa003601.15779791
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14045496
44TGF-beta signaling pathway_Homo sapiens_hsa043501.12904093
45Endometrial cancer_Homo sapiens_hsa052131.11954237
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10376578
47Inositol phosphate metabolism_Homo sapiens_hsa005621.09865452
48Non-small cell lung cancer_Homo sapiens_hsa052231.07452193
49Pyruvate metabolism_Homo sapiens_hsa006201.03102203
50Tyrosine metabolism_Homo sapiens_hsa003500.99684680
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97071175
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95883896
53Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93286989
54Biosynthesis of amino acids_Homo sapiens_hsa012300.92515309
55Renal cell carcinoma_Homo sapiens_hsa052110.91132490
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87429023
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.86668262
58Carbon metabolism_Homo sapiens_hsa012000.85964492
59Platelet activation_Homo sapiens_hsa046110.84908253
60Vitamin digestion and absorption_Homo sapiens_hsa049770.84461749
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83132454
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83101316
63Glioma_Homo sapiens_hsa052140.82906550
64* N-Glycan biosynthesis_Homo sapiens_hsa005100.80061441
65Melanoma_Homo sapiens_hsa052180.77587798
66One carbon pool by folate_Homo sapiens_hsa006700.74486412
67Fatty acid biosynthesis_Homo sapiens_hsa000610.74110552
68Folate biosynthesis_Homo sapiens_hsa007900.72816494
69PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72229767
70Thyroid hormone synthesis_Homo sapiens_hsa049180.72218214
71Hippo signaling pathway_Homo sapiens_hsa043900.71940226
72Glycerolipid metabolism_Homo sapiens_hsa005610.70664364
73Arginine and proline metabolism_Homo sapiens_hsa003300.70297710
74Insulin resistance_Homo sapiens_hsa049310.70128074
75Pathways in cancer_Homo sapiens_hsa052000.68737200
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.68437092
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68135289
78Tight junction_Homo sapiens_hsa045300.67215031
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67151921
80Steroid biosynthesis_Homo sapiens_hsa001000.66320169
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.65908965
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.65354130
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63000386
84Gap junction_Homo sapiens_hsa045400.62562599
85Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62274939
86ErbB signaling pathway_Homo sapiens_hsa040120.61116311
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61069250
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.60597234
89Sphingolipid metabolism_Homo sapiens_hsa006000.59806036
90Amoebiasis_Homo sapiens_hsa051460.59751286
91Renin secretion_Homo sapiens_hsa049240.58107891
92Prolactin signaling pathway_Homo sapiens_hsa049170.56358522
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54389727
94ECM-receptor interaction_Homo sapiens_hsa045120.53852988
95Acute myeloid leukemia_Homo sapiens_hsa052210.53718123
96Colorectal cancer_Homo sapiens_hsa052100.53694807
97Sulfur relay system_Homo sapiens_hsa041220.53481633
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53295316
99Renin-angiotensin system_Homo sapiens_hsa046140.53088009
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52696580
101mTOR signaling pathway_Homo sapiens_hsa041500.50623150
102Dorso-ventral axis formation_Homo sapiens_hsa043200.50402689
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50262294
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49784348
105Fatty acid elongation_Homo sapiens_hsa000620.48127020
106FoxO signaling pathway_Homo sapiens_hsa040680.47151616
107Rap1 signaling pathway_Homo sapiens_hsa040150.46639477
108Viral carcinogenesis_Homo sapiens_hsa052030.46468602
109Wnt signaling pathway_Homo sapiens_hsa043100.46085209
110Choline metabolism in cancer_Homo sapiens_hsa052310.45672203
111Glucagon signaling pathway_Homo sapiens_hsa049220.45422605
112Prion diseases_Homo sapiens_hsa050200.44968446
113Small cell lung cancer_Homo sapiens_hsa052220.44742612
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44445755
115Protein digestion and absorption_Homo sapiens_hsa049740.42644818
116Pentose phosphate pathway_Homo sapiens_hsa000300.41259767
117Focal adhesion_Homo sapiens_hsa045100.39866709
118Adherens junction_Homo sapiens_hsa045200.39853820
119Glutathione metabolism_Homo sapiens_hsa004800.38150502
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35968389
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33970228
122Malaria_Homo sapiens_hsa051440.31758079
123Other glycan degradation_Homo sapiens_hsa005110.31649052
124Proteoglycans in cancer_Homo sapiens_hsa052050.30880320
125Lysosome_Homo sapiens_hsa041420.29440328
126AMPK signaling pathway_Homo sapiens_hsa041520.29171536
127Bladder cancer_Homo sapiens_hsa052190.27682251
128Toxoplasmosis_Homo sapiens_hsa051450.27448492
129Pertussis_Homo sapiens_hsa051330.26597382
130Hepatitis C_Homo sapiens_hsa051600.25502197
131Leishmaniasis_Homo sapiens_hsa051400.25076720
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.24041232
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21335747
134Vitamin B6 metabolism_Homo sapiens_hsa007500.20672540
135Prostate cancer_Homo sapiens_hsa052150.20446815
136Pancreatic cancer_Homo sapiens_hsa052120.19263879
137Chronic myeloid leukemia_Homo sapiens_hsa052200.18822605
138Legionellosis_Homo sapiens_hsa051340.18390823
139Galactose metabolism_Homo sapiens_hsa000520.18081549
140Toll-like receptor signaling pathway_Homo sapiens_hsa046200.15771403
141Osteoclast differentiation_Homo sapiens_hsa043800.14725476
142TNF signaling pathway_Homo sapiens_hsa046680.13249231
143NF-kappa B signaling pathway_Homo sapiens_hsa040640.12907379
144Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.12774805

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