MAN2A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)6.67858622
2positive regulation of gamma-delta T cell activation (GO:0046645)5.23802672
3locomotory exploration behavior (GO:0035641)4.92558343
4synaptic vesicle maturation (GO:0016188)4.60115443
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.48374805
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.30617554
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.28500036
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.08921847
9negative regulation of cell killing (GO:0031342)4.08921847
10sodium ion export (GO:0071436)3.86100071
11regulation of gamma-delta T cell activation (GO:0046643)3.84168492
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.79778469
13regulation of gamma-delta T cell differentiation (GO:0045586)3.78916961
14positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.73816615
15antigen processing and presentation of endogenous antigen (GO:0019883)3.73224020
16synaptic vesicle docking involved in exocytosis (GO:0016081)3.66614146
17cellular potassium ion homeostasis (GO:0030007)3.61560348
18response to peptidoglycan (GO:0032494)3.58011457
19positive regulation by symbiont of host defense response (GO:0052509)3.57296227
20modulation by symbiont of host defense response (GO:0052031)3.57296227
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.57296227
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.57296227
23positive regulation by organism of defense response of other organism involved in symbiotic interact3.57296227
24modulation by symbiont of host immune response (GO:0052553)3.57296227
25response to muramyl dipeptide (GO:0032495)3.55179399
26vocalization behavior (GO:0071625)3.54269427
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50695069
28regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.50531578
29positive thymic T cell selection (GO:0045059)3.48317585
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.47508079
31regulation of synapse structural plasticity (GO:0051823)3.46705879
32synaptic vesicle exocytosis (GO:0016079)3.42777095
33megakaryocyte development (GO:0035855)3.41381648
34positive regulation of Rap GTPase activity (GO:0032854)3.39505769
35regulation of synaptic vesicle exocytosis (GO:2000300)3.39333394
36regulation of glutamate receptor signaling pathway (GO:1900449)3.39009198
37cellular extravasation (GO:0045123)3.36257325
38detection of other organism (GO:0098543)3.35274836
39positive regulation of B cell differentiation (GO:0045579)3.34959583
40regulation of B cell receptor signaling pathway (GO:0050855)3.34348323
41neutrophil activation involved in immune response (GO:0002283)3.33289521
42regulation of ARF protein signal transduction (GO:0032012)3.32439691
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.31803540
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.30407689
45cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.27743023
46layer formation in cerebral cortex (GO:0021819)3.27225874
47detection of bacterium (GO:0016045)3.26822298
48neuronal action potential propagation (GO:0019227)3.26437265
49B cell receptor signaling pathway (GO:0050853)3.26271241
50potassium ion import (GO:0010107)3.21144708
51exploration behavior (GO:0035640)3.18386864
52activation of protein kinase A activity (GO:0034199)3.18067536
53negative regulation of cytosolic calcium ion concentration (GO:0051481)3.17941180
54dendritic spine morphogenesis (GO:0060997)3.16113303
55regulation of mast cell degranulation (GO:0043304)3.14677051
56oxygen transport (GO:0015671)3.08747082
57protein localization to synapse (GO:0035418)3.08284663
58glutamate secretion (GO:0014047)3.08012354
59regulation of myeloid leukocyte mediated immunity (GO:0002886)3.06967484
60regulation of leukocyte degranulation (GO:0043300)3.06658715
61neurotransmitter secretion (GO:0007269)3.06576658
62ionotropic glutamate receptor signaling pathway (GO:0035235)3.05999658
63cerebellar Purkinje cell differentiation (GO:0021702)3.04181250
64regulation of neuronal synaptic plasticity (GO:0048168)3.02003845
65regulation of synaptic vesicle transport (GO:1902803)3.01919256
66positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.01097055
67thymic T cell selection (GO:0045061)3.00826457
68regulation of long-term neuronal synaptic plasticity (GO:0048169)2.99576681
69gas transport (GO:0015669)2.99218202
70positive regulation of granulocyte differentiation (GO:0030854)2.97390120
71prepulse inhibition (GO:0060134)2.97216817
72germinal center formation (GO:0002467)2.95830637
73macrophage activation involved in immune response (GO:0002281)2.94109580
74cell communication by electrical coupling (GO:0010644)2.94092238
75regulation of voltage-gated calcium channel activity (GO:1901385)2.93382893
76long-term memory (GO:0007616)2.92957194
77membrane depolarization during action potential (GO:0086010)2.92350521
78negative thymic T cell selection (GO:0045060)2.92138772
79regulation of ARF GTPase activity (GO:0032312)2.91389898
80definitive hemopoiesis (GO:0060216)2.90069454
81regulation of clathrin-mediated endocytosis (GO:2000369)2.89610878
82positive regulation of cellular amide metabolic process (GO:0034250)2.88782587
83regulation of regulated secretory pathway (GO:1903305)2.88590423
84negative regulation of lymphocyte mediated immunity (GO:0002707)2.87034926
85gamma-aminobutyric acid transport (GO:0015812)2.84654399
86neurotransmitter-gated ion channel clustering (GO:0072578)2.84637032
87creatine metabolic process (GO:0006600)2.84588436
88myeloid cell development (GO:0061515)2.83539862
89mucosal-associated lymphoid tissue development (GO:0048537)2.83103072
90Peyers patch development (GO:0048541)2.83103072
91detection of external biotic stimulus (GO:0098581)2.82705722
92T cell selection (GO:0045058)2.82390502
93positive T cell selection (GO:0043368)2.80728997
94regulation of mast cell activation involved in immune response (GO:0033006)2.80685283
95regulation of excitatory postsynaptic membrane potential (GO:0060079)2.80258018
96neuromuscular process controlling balance (GO:0050885)2.79624477
97glycine transport (GO:0015816)2.78147572
98regulation of Rap GTPase activity (GO:0032317)2.77924955
99regulation of erythrocyte differentiation (GO:0045646)2.77764474
100cellular sodium ion homeostasis (GO:0006883)2.74917332
101membrane hyperpolarization (GO:0060081)2.74730344
102regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.74427862
103striatum development (GO:0021756)2.74313884
104synaptic transmission, glutamatergic (GO:0035249)2.73934430
105erythrocyte development (GO:0048821)2.73583668
106regulation of postsynaptic membrane potential (GO:0060078)2.72517121
107establishment of nucleus localization (GO:0040023)2.72298449
108positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.71876210
109negative T cell selection (GO:0043383)2.71778068
110negative regulation of leukocyte mediated immunity (GO:0002704)2.71643364
111leukocyte aggregation (GO:0070486)2.71351824
112potassium ion homeostasis (GO:0055075)2.71044273
113response to interleukin-15 (GO:0070672)2.70957999
114L-amino acid import (GO:0043092)2.70400253
115regulation of histone H3-K27 methylation (GO:0061085)2.70037545
116regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.68551207
117positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.68080240
118regulation of macrophage cytokine production (GO:0010935)2.65722090
119neuron-neuron synaptic transmission (GO:0007270)2.65515532
120neuronal ion channel clustering (GO:0045161)2.65503079
121actin filament polymerization (GO:0030041)2.65000348
122glutamate receptor signaling pathway (GO:0007215)2.64171249
123positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.62641308
124regulation of calcium ion transmembrane transporter activity (GO:1901019)2.62201187
125regulation of calcium ion transmembrane transport (GO:1903169)2.62201187
126regulation of rhodopsin mediated signaling pathway (GO:0022400)2.61888630
127retinal cone cell development (GO:0046549)2.61541237
128JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.60807920
129detection of molecule of bacterial origin (GO:0032490)2.60666522
130positive regulation of membrane potential (GO:0045838)2.59924403
131rhodopsin mediated signaling pathway (GO:0016056)2.58869964
132dendrite morphogenesis (GO:0048813)2.58565194
133neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.58287595
134regulation of granulocyte differentiation (GO:0030852)2.57651311
135natural killer cell differentiation (GO:0001779)2.57619792
136negative regulation of T cell mediated immunity (GO:0002710)2.57397254
137protoporphyrinogen IX metabolic process (GO:0046501)2.56631899
138regulation of B cell differentiation (GO:0045577)2.56445956
139positive regulation of neurotransmitter transport (GO:0051590)2.55731587
140regulation of dendritic spine morphogenesis (GO:0061001)2.53311156
141neutrophil activation (GO:0042119)2.53301947
142cytoskeletal anchoring at plasma membrane (GO:0007016)2.52556441
143auditory behavior (GO:0031223)2.52344350
144G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.52079578
145membrane depolarization (GO:0051899)2.51593533
146response to auditory stimulus (GO:0010996)2.51197508
147proline transport (GO:0015824)2.49926809
148long-term synaptic potentiation (GO:0060291)2.49167952
149positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.48863554
150neurotransmitter transport (GO:0006836)2.47252731
151response to host immune response (GO:0052572)2.47179848
152response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.47179848
153regulation of amyloid precursor protein catabolic process (GO:1902991)2.46843168
154synaptic vesicle endocytosis (GO:0048488)2.46701292
155peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.46620727
156detection of biotic stimulus (GO:0009595)2.46136946
157myeloid cell activation involved in immune response (GO:0002275)2.45666852
158leukocyte degranulation (GO:0043299)2.44703944
159positive regulation of protein dephosphorylation (GO:0035307)2.43994326
160antigen processing and presentation via MHC class Ib (GO:0002475)2.42883081
161regulation of synaptic plasticity (GO:0048167)2.41762857
162negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.41653691
163regulation of beta-amyloid formation (GO:1902003)2.41449681
164regulation of synaptic transmission, glutamatergic (GO:0051966)2.41274411
165regulation of membrane repolarization (GO:0060306)2.40907186
166neuromuscular process controlling posture (GO:0050884)2.40689060
167response to host (GO:0075136)2.38685310
168response to host defenses (GO:0052200)2.38685310
169response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.38685310
170regulation of neurotransmitter secretion (GO:0046928)2.38572230
171mating behavior (GO:0007617)2.37700953
172regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.36606772
173positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.36599037
174regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.36015732
175cellular response to thyroid hormone stimulus (GO:0097067)2.35847968
176positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.35554163
177regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.35294011
178nerve growth factor signaling pathway (GO:0038180)2.34349543
179lipopolysaccharide-mediated signaling pathway (GO:0031663)2.34298098
180positive regulation of potassium ion transmembrane transport (GO:1901381)2.34172724
181transmission of nerve impulse (GO:0019226)2.33710591
182innervation (GO:0060384)2.33452324
183signal complex assembly (GO:0007172)2.33027796
184regulation of platelet aggregation (GO:0090330)2.32658139
185leukocyte migration involved in inflammatory response (GO:0002523)2.32621174
186positive regulation of mast cell activation (GO:0033005)2.32276606
187chemosensory behavior (GO:0007635)2.32126210
188cerebellar granule cell differentiation (GO:0021707)2.31868512
189macrophage activation (GO:0042116)2.31773184
190negative regulation of toll-like receptor signaling pathway (GO:0034122)2.31240794
191regulation of mast cell activation (GO:0033003)2.31231464
192* mannose metabolic process (GO:0006013)2.30116132
193positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.30048897
194regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.29623921
195membrane repolarization (GO:0086009)2.29191242
196dopamine receptor signaling pathway (GO:0007212)2.28943660

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.92778519
2* VDR_21846776_ChIP-Seq_THP-1_Human3.08519912
3DROSHA_22980978_ChIP-Seq_HELA_Human2.92334117
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.85787336
5MYC_22102868_ChIP-Seq_BL_Human2.84819549
6SCL_19346495_ChIP-Seq_HPC-7_Human2.80659537
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.61731686
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.53755179
9* GATA1_19941826_ChIP-Seq_K562_Human2.50182309
10GATA1_22025678_ChIP-Seq_K562_Human2.47247881
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.45653585
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.40949206
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.37440989
14* VDR_24763502_ChIP-Seq_THP-1_Human2.33773450
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.33716612
16SPI1_23127762_ChIP-Seq_K562_Human2.31144161
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29558131
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29558131
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19693336
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.18452406
21GBX2_23144817_ChIP-Seq_PC3_Human2.16841834
22GATA1_19941827_ChIP-Seq_MEL_Mouse2.13407669
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.13197022
24MAF_26560356_Chip-Seq_TH1_Human2.11923089
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07640803
26TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.05288123
27* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.03095937
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.02696128
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.99794439
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.96623587
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93099302
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92549633
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.89911241
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88290197
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.87752457
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87462558
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85432781
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.85379841
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.85355141
40UTX_26944678_Chip-Seq_JUKART_Human1.83872769
41AR_21572438_ChIP-Seq_LNCaP_Human1.83653957
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.81681348
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80322368
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77459160
45REST_21632747_ChIP-Seq_MESCs_Mouse1.77257102
46* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76587780
47* MAF_26560356_Chip-Seq_TH2_Human1.73893007
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.71003908
49* GATA2_19941826_ChIP-Seq_K562_Human1.68231784
50NCOR1_26117541_ChIP-Seq_K562_Human1.67113618
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66721076
52* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.65288378
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.63063852
54* KDM2B_26808549_Chip-Seq_K562_Human1.58938012
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58215378
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54224423
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.54208226
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.53586889
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51403197
60* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.50942259
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.50047921
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49492707
63* RACK7_27058665_Chip-Seq_MCF-7_Human1.48972031
64IRF8_27001747_Chip-Seq_BMDM_Mouse1.48808641
65* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45826922
66* REST_18959480_ChIP-ChIP_MESCs_Mouse1.45809424
67* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.43177921
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.42822008
69LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42796416
70P68_20966046_ChIP-Seq_HELA_Human1.42473573
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41310728
72GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40295720
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.37425482
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35686878
75SMC4_20622854_ChIP-Seq_HELA_Human1.35628861
76MYB_26560356_Chip-Seq_TH1_Human1.35226076
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34901892
78CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33666595
79* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32009510
80MYB_26560356_Chip-Seq_TH2_Human1.31798310
81GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30806607
82* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30289920
83* SA1_27219007_Chip-Seq_ERYTHROID_Human1.29311164
84* KDM2B_26808549_Chip-Seq_DND41_Human1.29171337
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28729871
86SPI1_23547873_ChIP-Seq_NB4_Human1.27544386
87PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.27020820
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26673012
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26501283
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.24974740
91* CREB1_26743006_Chip-Seq_LNCaP_Human1.24675525
92STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24318557
93AR_19668381_ChIP-Seq_PC3_Human1.24257165
94GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24191369
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23630996
96EP300_21415370_ChIP-Seq_HL-1_Mouse1.21873512
97ERG_21242973_ChIP-ChIP_JURKAT_Human1.21098040
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21050765
99ESR1_20079471_ChIP-ChIP_T-47D_Human1.21038119
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20528015
101SMAD4_21799915_ChIP-Seq_A2780_Human1.20443349
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20056820
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17827496
104* KDM2B_26808549_Chip-Seq_JURKAT_Human1.17480392
105EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17110538
106STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.16957300
107PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16731219
108AHR_22903824_ChIP-Seq_MCF-7_Human1.15996219
109GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15106384
110BCOR_27268052_Chip-Seq_Bcells_Human1.14523914
111RING1B_27294783_Chip-Seq_ESCs_Mouse1.14383159
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14199227
113LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14056859
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.13810310
115* SOX2_21211035_ChIP-Seq_LN229_Gbm1.13525126
116SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11490137
117TP53_16413492_ChIP-PET_HCT116_Human1.10467313
118NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09165627
119ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08456960
120* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08173806
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06719072
122CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05583911
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04795738
124ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03803375
125BCL6_27268052_Chip-Seq_Bcells_Human1.03376039
126STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02415612
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02005957
128CTCF_21964334_ChIP-Seq_BJAB-B_Human1.01541057
129IRF8_21731497_ChIP-ChIP_J774_Mouse1.00660704
130PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00178839
131SMAD3_21741376_ChIP-Seq_HESCs_Human0.99597654
132* STAT3_23295773_ChIP-Seq_U87_Human0.99129171
133STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98826017
134PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98064247
135RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97579666
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97338159
137GATA2_21666600_ChIP-Seq_HMVEC_Human0.96375194
138OCT4_19829295_ChIP-Seq_ESCs_Human0.96284218
139RING1B_27294783_Chip-Seq_NPCs_Mouse0.96095701
140MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96071245
141PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95729671
142MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94836477
143SMAD4_21741376_ChIP-Seq_HESCs_Human0.94287602
144CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94125664
145YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93568939
146SMAD_19615063_ChIP-ChIP_OVARY_Human0.93049976
147* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92765274
148LXR_22292898_ChIP-Seq_THP-1_Human0.92741280
149CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92167890
150FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.91499504
151P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91144232
152ZNF274_21170338_ChIP-Seq_K562_Hela0.91132513
153TCF4_23295773_ChIP-Seq_U87_Human0.90573063
154P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90257214
155RUNX_20019798_ChIP-Seq_JUKART_Human0.89855443
156RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89672055
157CTBP2_25329375_ChIP-Seq_LNCAP_Human0.88811267
158ESR2_21235772_ChIP-Seq_MCF-7_Human0.88582516
159TCF7_22412390_ChIP-Seq_EML_Mouse0.88550703
160TBX20_22328084_ChIP-Seq_HEART_Mouse0.87484762
161TBX20_22080862_ChIP-Seq_HEART_Mouse0.87484762
162* CTCF_27219007_Chip-Seq_Bcells_Human0.87347352
163SMAD3_21741376_ChIP-Seq_EPCs_Human0.87086112
164FOXA2_19822575_ChIP-Seq_HepG2_Human0.86535498
165RXR_22108803_ChIP-Seq_LS180_Human0.86490088
166SMAD3_21741376_ChIP-Seq_ESCs_Human0.86131220
167NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85622507
168TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85583774
169* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84293766
170ISL1_27105846_Chip-Seq_CPCs_Mouse0.84244591
171AR_25329375_ChIP-Seq_VCAP_Human0.84216506

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.27863950
2MP0003635_abnormal_synaptic_transmissio3.21194282
3MP0003436_decreased_susceptibility_to3.19955916
4MP0003303_peritoneal_inflammation3.17910981
5MP0005551_abnormal_eye_electrophysiolog2.98807768
6MP0002822_catalepsy2.95428125
7MP0005451_abnormal_body_composition2.87238577
8MP0000751_myopathy2.69766836
9MP0003656_abnormal_erythrocyte_physiolo2.69304156
10MP0003880_abnormal_central_pattern2.59313875
11MP0009046_muscle_twitch2.55012271
12MP0004270_analgesia2.52557114
13MP0009745_abnormal_behavioral_response2.51159800
14MP0005423_abnormal_somatic_nervous2.51055205
15MP0009278_abnormal_bone_marrow2.46522705
16MP0002064_seizures2.44605257
17MP0005464_abnormal_platelet_physiology2.43087871
18MP0003724_increased_susceptibility_to2.39195173
19MP0004145_abnormal_muscle_electrophysio2.36195937
20MP0002063_abnormal_learning/memory/cond2.36146062
21MP0001486_abnormal_startle_reflex2.20572163
22MP0005058_abnormal_lysosome_morphology2.18279782
23MP0002419_abnormal_innate_immunity2.18068994
24MP0008569_lethality_at_weaning2.17461618
25MP0001835_abnormal_antigen_presentation2.10660689
26MP0002272_abnormal_nervous_system2.08120087
27MP0009780_abnormal_chondrocyte_physiolo2.03839371
28MP0001545_abnormal_hematopoietic_system2.00638449
29MP0005397_hematopoietic_system_phenotyp2.00638449
30MP0002572_abnormal_emotion/affect_behav1.99162728
31MP0008260_abnormal_autophagy1.98611267
32MP0005025_abnormal_response_to1.97922598
33MP0004130_abnormal_muscle_cell1.97693895
34MP0002909_abnormal_adrenal_gland1.96867226
35MP0002837_dystrophic_cardiac_calcinosis1.91444758
36MP0000569_abnormal_digit_pigmentation1.88711497
37MP0005000_abnormal_immune_tolerance1.88104572
38MP0003300_gastrointestinal_ulcer1.88012899
39MP0003763_abnormal_thymus_physiology1.85994490
40MP0002396_abnormal_hematopoietic_system1.83784364
41MP0001800_abnormal_humoral_immune1.79892859
42MP0008961_abnormal_basal_metabolism1.79842890
43MP0001501_abnormal_sleep_pattern1.74476319
44MP0002090_abnormal_vision1.73797381
45MP0002420_abnormal_adaptive_immunity1.72975679
46MP0002398_abnormal_bone_marrow1.72235494
47MP0003191_abnormal_cellular_cholesterol1.71979092
48MP0003011_delayed_dark_adaptation1.69473423
49MP0001819_abnormal_immune_cell1.69244508
50MP0000685_abnormal_immune_system1.68595097
51MP0004147_increased_porphyrin_level1.68146600
52MP0002723_abnormal_immune_serum1.67609198
53MP0001790_abnormal_immune_system1.67294023
54MP0005387_immune_system_phenotype1.67294023
55MP0005253_abnormal_eye_physiology1.66841359
56MP0004036_abnormal_muscle_relaxation1.65349810
57MP0004885_abnormal_endolymph1.62798879
58MP0001968_abnormal_touch/_nociception1.61473179
59MP0003690_abnormal_glial_cell1.56726081
60MP0003045_fibrosis1.56494145
61MP0004233_abnormal_muscle_weight1.52893072
62MP0003646_muscle_fatigue1.49503371
63MP0006072_abnormal_retinal_apoptosis1.48703291
64MP0003828_pulmonary_edema1.47495409
65MP0002734_abnormal_mechanical_nocicepti1.46998593
66MP0002452_abnormal_antigen_presenting1.46876294
67MP0000749_muscle_degeneration1.46070032
68MP0004947_skin_inflammation1.43631250
69MP0002067_abnormal_sensory_capabilities1.43428081
70MP0000716_abnormal_immune_system1.39515472
71MP0004808_abnormal_hematopoietic_stem1.39208622
72MP0003329_amyloid_beta_deposits1.38933315
73MP0002229_neurodegeneration1.36239442
74MP0000747_muscle_weakness1.34739699
75MP0001440_abnormal_grooming_behavior1.34441062
76MP0000703_abnormal_thymus_morphology1.32226213
77MP0004924_abnormal_behavior1.32199323
78MP0005386_behavior/neurological_phenoty1.32199323
79MP0004087_abnormal_muscle_fiber1.31043035
80MP0005671_abnormal_response_to1.30769339
81MP0004084_abnormal_cardiac_muscle1.30676689
82MP0004381_abnormal_hair_follicle1.29717021
83MP0004858_abnormal_nervous_system1.28757506
84MP0005646_abnormal_pituitary_gland1.28742385
85MP0002722_abnormal_immune_system1.28685177
86MP0000013_abnormal_adipose_tissue1.28577954
87MP0002882_abnormal_neuron_morphology1.28058499
88MP0004811_abnormal_neuron_physiology1.27831449
89MP0003633_abnormal_nervous_system1.26987687
90MP0001851_eye_inflammation1.26717309
91MP0000015_abnormal_ear_pigmentation1.25524400
92MP0002132_abnormal_respiratory_system1.24836803
93MP0003879_abnormal_hair_cell1.24458247
94MP0001533_abnormal_skeleton_physiology1.23866823
95MP0002405_respiratory_system_inflammati1.23368574
96MP0009840_abnormal_foam_cell1.22084659
97MP0004215_abnormal_myocardial_fiber1.21939611
98MP0001502_abnormal_circadian_rhythm1.21854042
99MP0002429_abnormal_blood_cell1.21521108
100MP0005670_abnormal_white_adipose1.21059567
101MP0005620_abnormal_muscle_contractility1.20012911
102MP0000689_abnormal_spleen_morphology1.18603929
103MP0004510_myositis1.18226177
104MP0005076_abnormal_cell_differentiation1.18010981
105MP0002009_preneoplasia1.16519128
106MP0002557_abnormal_social/conspecific_i1.16377101
107MP0006082_CNS_inflammation1.14166809
108MP0000920_abnormal_myelination1.13021821
109MP0000759_abnormal_skeletal_muscle1.12519668
110MP0004085_abnormal_heartbeat1.11976555
111MP0005409_darkened_coat_color1.11916974
112MP0002971_abnormal_brown_adipose1.11610558
113MP0002184_abnormal_innervation1.10848579
114MP0009785_altered_susceptibility_to1.10063099
115MP0001984_abnormal_olfaction1.09878369
116MP0001970_abnormal_pain_threshold1.08806055
117MP0003866_abnormal_defecation1.07646610
118MP0000955_abnormal_spinal_cord1.07348973
119MP0003172_abnormal_lysosome_physiology1.06860171
120MP0010155_abnormal_intestine_physiology1.06763195
121MP0002066_abnormal_motor_capabilities/c1.05994811
122MP0002998_abnormal_bone_remodeling1.05614497
123MP0002106_abnormal_muscle_physiology1.05217592
124MP0003634_abnormal_glial_cell1.04761696
125MP0003075_altered_response_to1.03159859
126MP0003705_abnormal_hypodermis_morpholog1.03000812
127MP0005195_abnormal_posterior_eye1.01937711
128MP0003787_abnormal_imprinting1.00720083
129MP0000003_abnormal_adipose_tissue1.00309152
130MP0005623_abnormal_meninges_morphology0.99568731
131MP0005083_abnormal_biliary_tract0.99144198
132MP0000465_gastrointestinal_hemorrhage0.98766477
133MP0005375_adipose_tissue_phenotype0.98271465
134MP0005666_abnormal_adipose_tissue0.97164871
135MP0000604_amyloidosis0.96151890
136MP0002148_abnormal_hypersensitivity_rea0.95927479
137MP0002733_abnormal_thermal_nociception0.94795276
138MP0008874_decreased_physiological_sensi0.94283114
139MP0003631_nervous_system_phenotype0.94210680
140MP0002269_muscular_atrophy0.94137161
141MP0009333_abnormal_splenocyte_physiolog0.94001650
142MP0005369_muscle_phenotype0.93996351
143MP0001845_abnormal_inflammatory_respons0.93790301
144MP0005535_abnormal_body_temperature0.92921084
145MP0003183_abnormal_peptide_metabolism0.91961882
146MP0009115_abnormal_fat_cell0.90630732
147MP0003137_abnormal_impulse_conducting0.90040943
148MP0005330_cardiomyopathy0.89237171
149MP0004484_altered_response_of0.88884024
150MP0001299_abnormal_eye_distance/0.88665413
151MP0001177_atelectasis0.87710145
152MP0001873_stomach_inflammation0.87356739
153MP0004185_abnormal_adipocyte_glucose0.87026213
154MP0000778_abnormal_nervous_system0.87012264
155MP0002108_abnormal_muscle_morphology0.86484583
156MP0002735_abnormal_chemical_nociception0.83622229
157MP0002736_abnormal_nociception_after0.81473751
158MP0010630_abnormal_cardiac_muscle0.80948353
159MP0003950_abnormal_plasma_membrane0.80940681
160MP0002166_altered_tumor_susceptibility0.80527563
161MP0004742_abnormal_vestibular_system0.80135871
162MP0008469_abnormal_protein_level0.79934568
163MP0002752_abnormal_somatic_nervous0.78366524
164MP0005166_decreased_susceptibility_to0.78024993
165MP0002972_abnormal_cardiac_muscle0.76694764
166MP0002152_abnormal_brain_morphology0.75156418
167MP0001986_abnormal_taste_sensitivity0.74723556
168MP0000858_altered_metastatic_potential0.73710339
169MP0005167_abnormal_blood-brain_barrier0.73438020
170MP0001324_abnormal_eye_pigmentation0.73048514
171MP0006138_congestive_heart_failure0.72110402

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.56819752
2Central scotoma (HP:0000603)4.29725179
3Focal motor seizures (HP:0011153)4.15796299
4Eczematoid dermatitis (HP:0000976)3.85230666
5Prolonged bleeding time (HP:0003010)3.81577325
6Myokymia (HP:0002411)3.79153459
7Bony spicule pigmentary retinopathy (HP:0007737)3.65624189
8Focal seizures (HP:0007359)3.62622858
9Exercise-induced myalgia (HP:0003738)3.48927144
10Visual hallucinations (HP:0002367)3.39791904
11Abnormality of the heme biosynthetic pathway (HP:0010472)3.39189432
12Action tremor (HP:0002345)3.35049875
13Obstructive sleep apnea (HP:0002870)3.32089344
14Recurrent abscess formation (HP:0002722)3.31808917
15Scotoma (HP:0000575)3.28493709
16Dysmetric saccades (HP:0000641)3.16859771
17Reticulocytosis (HP:0001923)3.09647214
18Polycythemia (HP:0001901)3.07433063
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.05995445
20Recurrent bacterial skin infections (HP:0005406)3.04793055
21Abnormality of the fingertips (HP:0001211)3.02967321
22Abnormality of macular pigmentation (HP:0008002)2.98591582
23Obstructive lung disease (HP:0006536)2.95671775
24Chronic obstructive pulmonary disease (HP:0006510)2.95671775
25Abnormality of macrophages (HP:0004311)2.95539668
26Abnormal rod and cone electroretinograms (HP:0008323)2.94226961
27Pigmentary retinal degeneration (HP:0001146)2.92429105
28Spontaneous hematomas (HP:0007420)2.86257772
29Progressive cerebellar ataxia (HP:0002073)2.82410463
30Difficulty running (HP:0009046)2.82324787
31Supranuclear gaze palsy (HP:0000605)2.81478922
32Myositis (HP:0100614)2.77378786
33Absent rod-and cone-mediated responses on ERG (HP:0007688)2.76403470
34Epistaxis (HP:0000421)2.75594443
35Dysdiadochokinesis (HP:0002075)2.75531811
36Increased IgE level (HP:0003212)2.73978386
37Recurrent gram-negative bacterial infections (HP:0005420)2.73910416
38Hemiplegia (HP:0002301)2.70472955
39Dyschromatopsia (HP:0007641)2.69965863
40Cellulitis (HP:0100658)2.68393256
41Postural instability (HP:0002172)2.62601930
42Colitis (HP:0002583)2.61413625
43Recurrent fungal infections (HP:0002841)2.60897850
44Macroorchidism (HP:0000053)2.59749155
45Truncal ataxia (HP:0002078)2.58275015
46Febrile seizures (HP:0002373)2.57924818
47Epileptic encephalopathy (HP:0200134)2.55902506
48Depression (HP:0000716)2.52809185
49Urinary bladder sphincter dysfunction (HP:0002839)2.50088040
50Genetic anticipation (HP:0003743)2.49263080
51Broad-based gait (HP:0002136)2.48944145
52Slow saccadic eye movements (HP:0000514)2.47028055
53Gastrointestinal inflammation (HP:0004386)2.46818432
54Gaze-evoked nystagmus (HP:0000640)2.46761449
55Impaired social interactions (HP:0000735)2.46510505
56Abnormal social behavior (HP:0012433)2.46510505
57Bundle branch block (HP:0011710)2.46464318
58Centrally nucleated skeletal muscle fibers (HP:0003687)2.45709739
59Diplopia (HP:0000651)2.43288257
60Broad metatarsal (HP:0001783)2.42500794
61Prolonged QT interval (HP:0001657)2.42349036
62Gastrointestinal infarctions (HP:0005244)2.41788488
63Meningitis (HP:0001287)2.41105014
64Ankle clonus (HP:0011448)2.40534765
65Hypochromic microcytic anemia (HP:0004840)2.39759757
66Peripheral hypomyelination (HP:0007182)2.39452370
67Exercise-induced muscle cramps (HP:0003710)2.38636696
68Bowel incontinence (HP:0002607)2.38584733
69Cholecystitis (HP:0001082)2.38260125
70Abnormal gallbladder physiology (HP:0012438)2.38260125
71Chorioretinal atrophy (HP:0000533)2.38209849
72Cerebral aneurysm (HP:0004944)2.37807281
73Gingival bleeding (HP:0000225)2.37778868
74Orchitis (HP:0100796)2.36069378
75Poor eye contact (HP:0000817)2.35203450
76Inflammation of the large intestine (HP:0002037)2.34209788
77Hyperthyroidism (HP:0000836)2.31176880
78Truncus arteriosus (HP:0001660)2.30253869
79Hypochromic anemia (HP:0001931)2.29976858
80Abnormal delayed hypersensitivity skin test (HP:0002963)2.29235499
81Abolished electroretinogram (ERG) (HP:0000550)2.28845425
82Poikilocytosis (HP:0004447)2.28569501
83Dysmetria (HP:0001310)2.28057143
84Absence seizures (HP:0002121)2.27942529
85Hyperacusis (HP:0010780)2.26744287
86Atonic seizures (HP:0010819)2.26681509
87Increased variability in muscle fiber diameter (HP:0003557)2.25531175
88Hyporeflexia of lower limbs (HP:0002600)2.24867888
89Papilledema (HP:0001085)2.24534047
90Gingivitis (HP:0000230)2.23709064
91Decreased central vision (HP:0007663)2.23629235
92Impaired vibration sensation in the lower limbs (HP:0002166)2.23332466
93Intention tremor (HP:0002080)2.23303392
94Generalized tonic-clonic seizures (HP:0002069)2.22374065
95Muscle hypertrophy of the lower extremities (HP:0008968)2.21291509
96Abnormality of the lower motor neuron (HP:0002366)2.20734622
97Abnormal large intestine physiology (HP:0012700)2.20497618
98Calf muscle hypertrophy (HP:0008981)2.18645913
99Lower limb amyotrophy (HP:0007210)2.18312215
100Chest pain (HP:0100749)2.17886707
101Optic neuritis (HP:0100653)2.16167094
102Retrobulbar optic neuritis (HP:0100654)2.16167094
103Ventricular fibrillation (HP:0001663)2.15107944
104Insomnia (HP:0100785)2.14163604
105Type 1 muscle fiber predominance (HP:0003803)2.13608900
106Recurrent skin infections (HP:0001581)2.12632106
107Impaired smooth pursuit (HP:0007772)2.11494846
108Pointed chin (HP:0000307)2.09744779
109Sudden death (HP:0001699)2.08281588
110Hypertensive crisis (HP:0100735)2.08044201
111Chronic mucocutaneous candidiasis (HP:0002728)2.07307405
112Recurrent cutaneous fungal infections (HP:0011370)2.07307405
113Abnormality of the calf musculature (HP:0001430)2.07270937
114Urinary urgency (HP:0000012)2.05374631
115Cholelithiasis (HP:0001081)2.04415481
116Abnormal EKG (HP:0003115)2.03973558
117Onion bulb formation (HP:0003383)2.03296320
118Microcytic anemia (HP:0001935)2.02753992
119Purpura (HP:0000979)2.02537117
120Recurrent viral infections (HP:0004429)2.01098558
121Petechiae (HP:0000967)2.00304595
122Muscle fiber splitting (HP:0003555)1.99918948
123EMG: neuropathic changes (HP:0003445)1.99744819
124Ocular albinism (HP:0001107)1.98482327
125Upper limb amyotrophy (HP:0009129)1.98272057
126Distal upper limb amyotrophy (HP:0007149)1.98272057
127Dialeptic seizures (HP:0011146)1.97574416
128Abnormality of ocular smooth pursuit (HP:0000617)1.97427674
129Anxiety (HP:0000739)1.96766775
130Abnormality of skeletal muscle fiber size (HP:0012084)1.96075128
131Impaired platelet aggregation (HP:0003540)1.94863666
132Abnormal platelet function (HP:0011869)1.94863666
133Scanning speech (HP:0002168)1.94823033
134Encephalitis (HP:0002383)1.94168353
135Stomatitis (HP:0010280)1.93474512
136Dysostosis multiplex (HP:0000943)1.92335489
137Elfin facies (HP:0004428)1.92014307
138Elevated erythrocyte sedimentation rate (HP:0003565)1.91261542
139Arterial thrombosis (HP:0004420)1.89705206
140Torticollis (HP:0000473)1.89166187
141Abnormal platelet volume (HP:0011876)1.89089406
142Pendular nystagmus (HP:0012043)1.88892648
143Osteomyelitis (HP:0002754)1.87919264
144Episodic fever (HP:0001954)1.87799047
145Annular pancreas (HP:0001734)1.87736017
146Atrial fibrillation (HP:0005110)1.87317893
147Mediastinal lymphadenopathy (HP:0100721)1.86031719
148Decreased motor nerve conduction velocity (HP:0003431)1.85037468
149Segmental peripheral demyelination/remyelination (HP:0003481)1.84893300
150Myotonia (HP:0002486)1.84771192
151Pulmonary embolism (HP:0002204)1.84310938
152Vasculitis (HP:0002633)1.84289229
153Abnormal hemoglobin (HP:0011902)1.84087303
154Panhypogammaglobulinemia (HP:0003139)1.83950480
155Abnormality of the left ventricular outflow tract (HP:0011103)1.83916895
156Subaortic stenosis (HP:0001682)1.83916895
157Choroideremia (HP:0001139)1.83897431
158Resting tremor (HP:0002322)1.83566024
159Hemorrhage of the eye (HP:0011885)1.83270581
160Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.83028835
161Neuronal loss in central nervous system (HP:0002529)1.83010350
162Type II diabetes mellitus (HP:0005978)1.82640626
163Macular degeneration (HP:0000608)1.82584243
164Foot dorsiflexor weakness (HP:0009027)1.82567059
165Granulocytopenia (HP:0001913)1.82464269
166Metaphyseal cupping (HP:0003021)1.81932315
167Fatigue (HP:0012378)1.81756303
168Primary atrial arrhythmia (HP:0001692)1.81102352
169Rapidly progressive (HP:0003678)1.80700076
170Attenuation of retinal blood vessels (HP:0007843)1.80266375
171Spastic gait (HP:0002064)1.79757109
172Increased serum ferritin (HP:0003281)1.78218813
173Easy fatigability (HP:0003388)1.78001418
174Distal lower limb amyotrophy (HP:0008944)1.77392041
175Menorrhagia (HP:0000132)1.77001115
176Abnormality of saccadic eye movements (HP:0000570)1.76316796
177Stereotypic behavior (HP:0000733)1.75822624
178Neoplasm of the heart (HP:0100544)1.75239954
179Lower limb muscle weakness (HP:0007340)1.73943329
180Asymmetric septal hypertrophy (HP:0001670)1.71905155
181Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68724010
182Frequent falls (HP:0002359)1.68123464
183Hypoventilation (HP:0002791)1.67174662
184Abnormal eating behavior (HP:0100738)1.66423266
185Abnormality of binocular vision (HP:0011514)1.65069646

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA42.91968993
2NTRK32.91871430
3TRIB32.53047847
4PRKD32.50011245
5MAP2K32.46855986
6CAMK1G2.28418198
7ERN12.21400001
8MAP4K12.20121013
9MAP3K92.05491412
10SIK22.00526749
11MAP3K41.92735665
12CAMKK11.88256731
13RIPK11.85438369
14NTRK21.85255424
15PAK61.80226897
16TYK21.78118237
17STK381.71078829
18DAPK21.67553415
19CAMK1D1.67227492
20PHKG11.65614812
21PHKG21.65614812
22FES1.63886113
23NTRK11.60797047
24PRKCH1.57732470
25TYRO31.54840892
26ZAP701.53678414
27PKN21.53583307
28DMPK1.49712780
29SIK11.43762735
30RIPK41.41117415
31MINK11.41014002
32TTN1.40294100
33IRAK41.37086685
34BLK1.36526685
35ICK1.34477129
36BTK1.33587091
37MAP3K71.33090974
38CDK121.31776715
39KSR21.29620473
40SGK31.27829893
41WNK11.27178344
42MAP2K41.25121683
43LMTK21.21009341
44JAK21.21007900
45PINK11.20763000
46MAP3K111.20632253
47MARK11.18693009
48SYK1.18417333
49SMG11.17605038
50CDK51.14690259
51GRK61.09868114
52RET1.09217836
53RAF11.09165973
54MAP3K101.05817595
55EPHB11.04833586
56MARK21.03816833
57SGK21.02955737
58SGK2231.02254648
59SGK4941.02254648
60MARK31.00306403
61CSK1.00263488
62TNK20.99705241
63CAMK10.99124448
64PRPF4B0.99109855
65EEF2K0.98775030
66PDGFRA0.98298310
67TAOK10.97917337
68FGFR40.96504742
69MAP3K130.95503510
70KSR10.95135501
71PDK10.94846719
72STK110.94452262
73ALK0.93893554
74TAOK30.92279877
75ITK0.91562062
76MAP3K30.91298570
77JAK30.90994532
78TNIK0.90628905
79FGFR20.89527073
80BMPR20.88469487
81CAMKK20.88075232
82MAP3K60.87272698
83PDPK10.85871493
84MAP3K140.85793177
85IRAK20.84384624
86MAPK120.80788090
87SGK10.79452595
88CDC42BPA0.79041033
89TRPM70.76481752
90MAP2K70.76476494
91PRKD20.75797849
92MAP2K60.74750805
93JAK10.73826409
94CAMK40.73703134
95GRK10.72799790
96TAOK20.72633135
97TBK10.70614795
98PTK2B0.70515065
99PDGFRB0.70382901
100TEC0.69699377
101PNCK0.69217111
102PRKD10.69037422
103MAP3K20.68955301
104IRAK30.67780362
105UHMK10.64333253
106HIPK20.62720641
107RPS6KA30.62216421
108PTK60.62073130
109MAPK130.60996995
110OBSCN0.60915533
111MTOR0.60554790
112IRAK10.60371866
113FYN0.58808510
114BMX0.58571235
115LYN0.58269277
116DDR20.58178392
117MAPK110.56447925
118LCK0.54633210
119YES10.53013549
120PAK30.52870726
121PRKCG0.51880718
122ARAF0.51601456
123PRKAA10.50986781
124KIT0.50597174
125IKBKE0.49961850
126LRRK20.49255080
127HCK0.49222257
128MAPK100.48998338
129MAP3K10.48915685
130PRKAA20.48905951
131MAPK70.48288952
132MATK0.48089389
133RPS6KL10.47881572
134RPS6KC10.47881572
135FGFR30.46269686
136CAMK2A0.45317721
137MAP2K20.44862476
138DAPK10.44800660
139SIK30.44275500
140RPS6KA20.42836481
141PKN10.42080142
142PRKCZ0.41304998
143ROCK10.40133168
144ROCK20.39788528
145MAPK80.39089242
146PDK30.38247620

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.25711094
2Olfactory transduction_Homo sapiens_hsa047402.28931806
3Acute myeloid leukemia_Homo sapiens_hsa052212.18714024
4Circadian entrainment_Homo sapiens_hsa047132.09983807
5Nicotine addiction_Homo sapiens_hsa050332.03349249
6GABAergic synapse_Homo sapiens_hsa047272.00402178
7Morphine addiction_Homo sapiens_hsa050321.97638341
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.95298218
9Synaptic vesicle cycle_Homo sapiens_hsa047211.91602685
10Glutamatergic synapse_Homo sapiens_hsa047241.90464653
11Other glycan degradation_Homo sapiens_hsa005111.85303158
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.84437656
13Long-term potentiation_Homo sapiens_hsa047201.82572375
14Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78229832
15Leishmaniasis_Homo sapiens_hsa051401.76491027
16Salivary secretion_Homo sapiens_hsa049701.74004380
17Cholinergic synapse_Homo sapiens_hsa047251.65862942
18Gastric acid secretion_Homo sapiens_hsa049711.64848516
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64503710
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.61351758
21Renin secretion_Homo sapiens_hsa049241.60571810
22Amphetamine addiction_Homo sapiens_hsa050311.57520341
23Oxytocin signaling pathway_Homo sapiens_hsa049211.56492079
24Dopaminergic synapse_Homo sapiens_hsa047281.56431230
25Insulin secretion_Homo sapiens_hsa049111.54792105
26Nitrogen metabolism_Homo sapiens_hsa009101.52009138
27Type II diabetes mellitus_Homo sapiens_hsa049301.45936480
28Dilated cardiomyopathy_Homo sapiens_hsa054141.44540780
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40536328
30Calcium signaling pathway_Homo sapiens_hsa040201.38399639
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.38111480
32Cocaine addiction_Homo sapiens_hsa050301.32043682
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.30252389
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.29862276
35cGMP-PKG signaling pathway_Homo sapiens_hsa040221.28038920
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.27081906
37cAMP signaling pathway_Homo sapiens_hsa040241.26141432
38Pancreatic cancer_Homo sapiens_hsa052121.24508955
39Tuberculosis_Homo sapiens_hsa051521.21148479
40GnRH signaling pathway_Homo sapiens_hsa049121.21032852
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19172065
42Staphylococcus aureus infection_Homo sapiens_hsa051501.17781059
43Glioma_Homo sapiens_hsa052141.13576058
44Long-term depression_Homo sapiens_hsa047301.12181808
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08376560
46Estrogen signaling pathway_Homo sapiens_hsa049151.06957421
47Taste transduction_Homo sapiens_hsa047421.03547862
48Phospholipase D signaling pathway_Homo sapiens_hsa040721.01550317
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99383993
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99071774
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98824807
52Dorso-ventral axis formation_Homo sapiens_hsa043200.97882485
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97803396
54Measles_Homo sapiens_hsa051620.96763286
55Gap junction_Homo sapiens_hsa045400.96599571
56Serotonergic synapse_Homo sapiens_hsa047260.96539457
57Malaria_Homo sapiens_hsa051440.96120980
58Influenza A_Homo sapiens_hsa051640.96096049
59Toxoplasmosis_Homo sapiens_hsa051450.95098739
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94167254
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.94089784
62Hepatitis B_Homo sapiens_hsa051610.93988748
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.92927073
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92678669
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92489773
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91914214
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90455914
68Notch signaling pathway_Homo sapiens_hsa043300.89839620
69mTOR signaling pathway_Homo sapiens_hsa041500.88854744
70Glucagon signaling pathway_Homo sapiens_hsa049220.88262921
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88151570
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.85672588
73ErbB signaling pathway_Homo sapiens_hsa040120.85055134
74Prion diseases_Homo sapiens_hsa050200.84244932
75Fatty acid biosynthesis_Homo sapiens_hsa000610.83472796
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81986269
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81761955
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.81059932
79TNF signaling pathway_Homo sapiens_hsa046680.80992712
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.79605651
81HIF-1 signaling pathway_Homo sapiens_hsa040660.79208763
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.79059151
83Hepatitis C_Homo sapiens_hsa051600.78279764
84Axon guidance_Homo sapiens_hsa043600.78263877
85FoxO signaling pathway_Homo sapiens_hsa040680.77106719
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.77001183
87MAPK signaling pathway_Homo sapiens_hsa040100.76630262
88Thyroid hormone synthesis_Homo sapiens_hsa049180.76496462
89Non-small cell lung cancer_Homo sapiens_hsa052230.76434285
90Insulin signaling pathway_Homo sapiens_hsa049100.76156367
91Insulin resistance_Homo sapiens_hsa049310.75563304
92Pancreatic secretion_Homo sapiens_hsa049720.75454494
93Melanogenesis_Homo sapiens_hsa049160.74621445
94Choline metabolism in cancer_Homo sapiens_hsa052310.73287396
95VEGF signaling pathway_Homo sapiens_hsa043700.72870709
96Inositol phosphate metabolism_Homo sapiens_hsa005620.72212983
97Circadian rhythm_Homo sapiens_hsa047100.72176124
98Cardiac muscle contraction_Homo sapiens_hsa042600.71544207
99Platelet activation_Homo sapiens_hsa046110.71087065
100Hematopoietic cell lineage_Homo sapiens_hsa046400.69223482
101B cell receptor signaling pathway_Homo sapiens_hsa046620.68174529
102Primary immunodeficiency_Homo sapiens_hsa053400.65346110
103Renal cell carcinoma_Homo sapiens_hsa052110.65171980
104African trypanosomiasis_Homo sapiens_hsa051430.64622429
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.64193428
106AMPK signaling pathway_Homo sapiens_hsa041520.63855975
107Chemokine signaling pathway_Homo sapiens_hsa040620.62132217
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61879510
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61731587
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61329067
111Focal adhesion_Homo sapiens_hsa045100.61294405
112Rap1 signaling pathway_Homo sapiens_hsa040150.59102872
113Apoptosis_Homo sapiens_hsa042100.58206602
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56425479
115Bile secretion_Homo sapiens_hsa049760.56414089
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.55951064
117Graft-versus-host disease_Homo sapiens_hsa053320.55632694
118Endocytosis_Homo sapiens_hsa041440.55367386
119Colorectal cancer_Homo sapiens_hsa052100.55129917
120Lysine degradation_Homo sapiens_hsa003100.54947804
121Chronic myeloid leukemia_Homo sapiens_hsa052200.54758910
122Allograft rejection_Homo sapiens_hsa053300.54451945
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53786695
124Endometrial cancer_Homo sapiens_hsa052130.53692887
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52799976
126Ras signaling pathway_Homo sapiens_hsa040140.49424473
127Proteoglycans in cancer_Homo sapiens_hsa052050.48616012
128Osteoclast differentiation_Homo sapiens_hsa043800.48542009
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.47214496
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44532600
131Ovarian steroidogenesis_Homo sapiens_hsa049130.43476043
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42227609
133Amoebiasis_Homo sapiens_hsa051460.41507923
134Glycerolipid metabolism_Homo sapiens_hsa005610.40090784
135Prolactin signaling pathway_Homo sapiens_hsa049170.39252820
136Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38628708
137T cell receptor signaling pathway_Homo sapiens_hsa046600.37726140

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