MAN2B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.08833300
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.08833300
3alpha-linolenic acid metabolic process (GO:0036109)4.08013454
4protein carboxylation (GO:0018214)4.00379276
5peptidyl-glutamic acid carboxylation (GO:0017187)4.00379276
6apoptotic cell clearance (GO:0043277)3.84860471
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.81277891
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.77315633
9negative regulation of cell killing (GO:0031342)3.77315633
10complement activation, alternative pathway (GO:0006957)3.75102200
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.75052403
12positive regulation by organism of defense response of other organism involved in symbiotic interact3.75052403
13modulation by symbiont of host immune response (GO:0052553)3.75052403
14positive regulation by symbiont of host defense response (GO:0052509)3.75052403
15modulation by symbiont of host defense response (GO:0052031)3.75052403
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.75052403
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.68547841
18regulation of interferon-beta biosynthetic process (GO:0045357)3.57454509
19antigen processing and presentation of endogenous antigen (GO:0019883)3.57049538
20low-density lipoprotein particle clearance (GO:0034383)3.46026213
21plasma lipoprotein particle clearance (GO:0034381)3.35001721
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.34338219
23L-phenylalanine catabolic process (GO:0006559)3.34338219
24regulation of protein activation cascade (GO:2000257)3.32286050
25negative regulation of fibrinolysis (GO:0051918)3.31505334
26regulation of complement activation (GO:0030449)3.26341743
27sulfur amino acid catabolic process (GO:0000098)3.23746045
28L-phenylalanine metabolic process (GO:0006558)3.23655825
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.23655825
30Golgi transport vesicle coating (GO:0048200)3.23551927
31COPI coating of Golgi vesicle (GO:0048205)3.23551927
32regulation of cholesterol storage (GO:0010885)3.18070104
33regulation of cholesterol homeostasis (GO:2000188)3.17299159
34reverse cholesterol transport (GO:0043691)3.16509807
35high-density lipoprotein particle remodeling (GO:0034375)3.16165016
36macrophage activation involved in immune response (GO:0002281)3.08953800
37phospholipid efflux (GO:0033700)3.07152462
38urea cycle (GO:0000050)3.06096108
39urea metabolic process (GO:0019627)3.06096108
40valine metabolic process (GO:0006573)3.04757859
41keratan sulfate catabolic process (GO:0042340)3.04155431
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.99283632
43virion attachment to host cell (GO:0019062)2.94932514
44adhesion of symbiont to host cell (GO:0044650)2.94932514
45response to peptidoglycan (GO:0032494)2.91916263
46plasma lipoprotein particle remodeling (GO:0034369)2.90248137
47protein-lipid complex remodeling (GO:0034368)2.90248137
48macromolecular complex remodeling (GO:0034367)2.90248137
49regulation of cholesterol esterification (GO:0010872)2.89448881
50complement activation (GO:0006956)2.89147522
51negative regulation of erythrocyte differentiation (GO:0045647)2.88047308
52regulation of apoptotic cell clearance (GO:2000425)2.86335447
53detection of other organism (GO:0098543)2.84313198
54regulation of fibrinolysis (GO:0051917)2.83906727
55protein-lipid complex assembly (GO:0065005)2.83390079
56complement activation, classical pathway (GO:0006958)2.83209655
57positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.82953120
58regulation of fatty acid beta-oxidation (GO:0031998)2.82908581
59aromatic amino acid family catabolic process (GO:0009074)2.81448970
60phospholipid homeostasis (GO:0055091)2.81357625
61regulation of extracellular matrix disassembly (GO:0010715)2.80665248
62plasma lipoprotein particle assembly (GO:0034377)2.77906530
634-hydroxyproline metabolic process (GO:0019471)2.77171601
64barbed-end actin filament capping (GO:0051016)2.76802777
65negative regulation of interleukin-12 production (GO:0032695)2.76345372
66lipoprotein metabolic process (GO:0042157)2.75785494
67positive regulation of fatty acid beta-oxidation (GO:0032000)2.75239373
68nitrogen cycle metabolic process (GO:0071941)2.73055783
69cholesterol efflux (GO:0033344)2.72788634
70detection of bacterium (GO:0016045)2.71480173
71detection of external biotic stimulus (GO:0098581)2.71437323
72regulation of triglyceride catabolic process (GO:0010896)2.70966563
73positive regulation of gamma-delta T cell activation (GO:0046645)2.69497683
74cellular extravasation (GO:0045123)2.69448890
75negative regulation of sterol transport (GO:0032372)2.67025957
76negative regulation of cholesterol transport (GO:0032375)2.67025957
77L-alpha-amino acid transmembrane transport (GO:1902475)2.66497207
78positive regulation of triglyceride metabolic process (GO:0090208)2.65170429
79amino-acid betaine metabolic process (GO:0006577)2.64560752
80positive regulation of triglyceride biosynthetic process (GO:0010867)2.64428185
81cysteine metabolic process (GO:0006534)2.63332419
82adhesion of symbiont to host (GO:0044406)2.60947636
83low-density lipoprotein particle remodeling (GO:0034374)2.60467847
84bile acid biosynthetic process (GO:0006699)2.60391550
85glyoxylate metabolic process (GO:0046487)2.60236195
86positive regulation of coagulation (GO:0050820)2.59900903
87protein-lipid complex subunit organization (GO:0071825)2.59773875
88regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.59091560
89positive regulation of fatty acid biosynthetic process (GO:0045723)2.58380116
90maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.57420451
91positive regulation of hemostasis (GO:1900048)2.57338015
92positive regulation of blood coagulation (GO:0030194)2.57338015
93positive regulation of lipid catabolic process (GO:0050996)2.55700698
94positive regulation of interferon-alpha production (GO:0032727)2.55234912
95plasma lipoprotein particle organization (GO:0071827)2.55119764
96kynurenine metabolic process (GO:0070189)2.55080187
97cellular modified amino acid catabolic process (GO:0042219)2.54894707
98protein activation cascade (GO:0072376)2.54176386
99response to muramyl dipeptide (GO:0032495)2.54070407
100positive regulation of histone deacetylation (GO:0031065)2.53961480
101regulation of gamma-delta T cell activation (GO:0046643)2.53697729
102homocysteine metabolic process (GO:0050667)2.52428830
103positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.51835588
104detection of molecule of bacterial origin (GO:0032490)2.51459258
105opsonization (GO:0008228)2.51007623
106protein localization to endosome (GO:0036010)2.50884158
107regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.50538407
108neutrophil activation involved in immune response (GO:0002283)2.48825277
109lysine metabolic process (GO:0006553)2.47900602
110lysine catabolic process (GO:0006554)2.47900602
111response to type I interferon (GO:0034340)2.46277928
112negative regulation of granulocyte differentiation (GO:0030853)2.46172467
113pentose-phosphate shunt (GO:0006098)2.46124341
114protein retention in ER lumen (GO:0006621)2.46042365
115activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.45885261
116regulation of leukocyte degranulation (GO:0043300)2.43231831
117type I interferon signaling pathway (GO:0060337)2.43132780
118cellular response to type I interferon (GO:0071357)2.43132780
119skin morphogenesis (GO:0043589)2.41927032
120regulation of interferon-alpha production (GO:0032647)2.41219065
121* mannose metabolic process (GO:0006013)2.40833410
122regulation of membrane protein ectodomain proteolysis (GO:0051043)2.40411560
123tricarboxylic acid metabolic process (GO:0072350)2.39473145
124leukocyte aggregation (GO:0070486)2.35960167
125negative regulation of interleukin-6 production (GO:0032715)2.34550504
126positive thymic T cell selection (GO:0045059)2.34472131
127negative regulation of type 2 immune response (GO:0002829)2.34448402
128positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.33012684
129negative regulation of lymphocyte mediated immunity (GO:0002707)2.32943098
130response to laminar fluid shear stress (GO:0034616)2.32807918
131negative regulation of leukocyte mediated immunity (GO:0002704)2.31259887
132regulation of myeloid leukocyte mediated immunity (GO:0002886)2.30545234
133detection of biotic stimulus (GO:0009595)2.30248598
134regulation of mast cell degranulation (GO:0043304)2.29149508
135stress fiber assembly (GO:0043149)2.29091082
136regulation of T cell tolerance induction (GO:0002664)2.27958107
137regulation of gamma-delta T cell differentiation (GO:0045586)2.27805570
138positive regulation of extracellular matrix organization (GO:1903055)2.25723040
139germinal center formation (GO:0002467)2.25443298
140regulation of dendritic cell antigen processing and presentation (GO:0002604)2.23465152
141regulation of B cell receptor signaling pathway (GO:0050855)2.20461361
142lipopolysaccharide-mediated signaling pathway (GO:0031663)2.19177959
143regulation of macrophage cytokine production (GO:0010935)2.18219708
144immunoglobulin mediated immune response (GO:0016064)2.18023496
145positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.17035063
146negative thymic T cell selection (GO:0045060)2.15664101
147positive regulation of receptor recycling (GO:0001921)2.14383234
148regulation of tolerance induction (GO:0002643)2.13988251
149regulation of T-helper 2 cell differentiation (GO:0045628)2.12537481
150interferon-gamma-mediated signaling pathway (GO:0060333)2.11724245
151response to host (GO:0075136)2.11585834
152response to host defenses (GO:0052200)2.11585834
153response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.11585834
154negative regulation of cytokine production involved in immune response (GO:0002719)2.11339045
155negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.10759589
156positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.10204340
157macrophage activation (GO:0042116)2.09514063
158regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.09073284
159antigen processing and presentation via MHC class Ib (GO:0002475)2.08696625
160endodermal cell differentiation (GO:0035987)2.08578500
161regulation of regulated secretory pathway (GO:1903305)2.08000173
162negative T cell selection (GO:0043383)2.07729040
163positive regulation of cellular amide metabolic process (GO:0034250)2.07178053
164response to host immune response (GO:0052572)2.06557517
165response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.06557517
166type B pancreatic cell proliferation (GO:0044342)2.06488584
167thymic T cell selection (GO:0045061)2.06199981
168tolerance induction (GO:0002507)2.05949289
169regulation of mast cell activation involved in immune response (GO:0033006)2.05734052
170regulation of T cell mediated cytotoxicity (GO:0001914)2.04583983
171regulation of type 2 immune response (GO:0002828)2.04224088
172NIK/NF-kappaB signaling (GO:0038061)2.03321547
173negative regulation of fatty acid transport (GO:2000192)2.02980677
174T cell selection (GO:0045058)2.02510030
175negative regulation of T cell mediated immunity (GO:0002710)2.02162436
176protein heterotrimerization (GO:0070208)2.01977565
177regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.01699736
178negative regulation of innate immune response (GO:0045824)2.00896450
179negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)1.98777593
180myeloid dendritic cell differentiation (GO:0043011)1.97883639

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.55685132
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.10449238
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.80529619
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.61802179
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.37036637
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.07025493
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.55668046
8* IRF8_21731497_ChIP-ChIP_J774_Mouse2.51297799
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.40945635
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.38707505
11* IRF8_27001747_Chip-Seq_BMDM_Mouse2.37115058
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.37069866
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32728226
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.27395085
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.22900763
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.04457749
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.03833430
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.03534741
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.01231057
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.01190198
21VDR_21846776_ChIP-Seq_THP-1_Human1.99529921
22CLOCK_20551151_ChIP-Seq_293T_Human1.98655554
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.97183437
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.96990506
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.95023073
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.91536451
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.89491851
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.85046660
29GATA1_22025678_ChIP-Seq_K562_Human1.83532991
30* LXR_22292898_ChIP-Seq_THP-1_Human1.78534090
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.76248899
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74228750
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73227359
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72469570
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.70809329
36SCL_19346495_ChIP-Seq_HPC-7_Human1.68457309
37MYC_22102868_ChIP-Seq_BL_Human1.65807753
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65434694
39TCF7_22412390_ChIP-Seq_EML_Mouse1.63962816
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.63082511
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.61902177
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61699746
43* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59174763
44CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.55989150
45VDR_24763502_ChIP-Seq_THP-1_Human1.54818442
46SPI1_23127762_ChIP-Seq_K562_Human1.53429642
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53086775
48MAF_26560356_Chip-Seq_TH1_Human1.44454936
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39012515
50* KDM2B_26808549_Chip-Seq_K562_Human1.38161087
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.36808225
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.36455439
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35620082
54RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33157801
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31311969
56* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30855420
57KDM2B_26808549_Chip-Seq_DND41_Human1.29536414
58PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29316943
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.27851841
60FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27081170
61UTX_26944678_Chip-Seq_JUKART_Human1.26769046
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.26634873
63RUNX_20019798_ChIP-Seq_JUKART_Human1.25344432
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24613658
65MYB_26560356_Chip-Seq_TH2_Human1.19352033
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18406843
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.18137403
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17967742
69DROSHA_22980978_ChIP-Seq_HELA_Human1.17311213
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16909743
71* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16770966
72TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.16625527
73GATA1_19941826_ChIP-Seq_K562_Human1.16506890
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15739114
75PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15112466
76STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.14741584
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14157544
78RACK7_27058665_Chip-Seq_MCF-7_Human1.13553565
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12578078
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.11979963
81FOXA2_19822575_ChIP-Seq_HepG2_Human1.10329359
82GATA2_21666600_ChIP-Seq_HMVEC_Human1.10100705
83P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09680579
84MYB_26560356_Chip-Seq_TH1_Human1.09510066
85* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08117457
86PU_27001747_Chip-Seq_BMDM_Mouse1.07537551
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07533885
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07053799
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06268565
90GATA2_19941826_ChIP-Seq_K562_Human1.04417536
91* SPI1_23547873_ChIP-Seq_NB4_Human1.04171016
92MAF_26560356_Chip-Seq_TH2_Human1.04161850
93* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04037518
94CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03089952
95FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02539390
96SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02283165
97ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02282137
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02152354
99* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02072758
100SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01482377
101* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00960443
102FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00584172
103ESR1_21235772_ChIP-Seq_MCF-7_Human1.00525389
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00466956
105STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00320518
106LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00088909
107DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99244590
108VDR_24787735_ChIP-Seq_THP-1_Human0.98916760
109MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98708555
110UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97681735
111SA1_27219007_Chip-Seq_ERYTHROID_Human0.96397829
112TP53_22127205_ChIP-Seq_IMR90_Human0.96064062
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95153654
114STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95093532
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94875826
116TBX20_22328084_ChIP-Seq_HEART_Mouse0.94799720
117TBX20_22080862_ChIP-Seq_HEART_Mouse0.94799720
118P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94658457
119NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94565108
120FOXO3_23340844_ChIP-Seq_DLD1_Human0.93955510
121PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92798318
122SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92735349
123NCOR1_26117541_ChIP-Seq_K562_Human0.92099279
124GATA3_27048872_Chip-Seq_THYMUS_Human0.91697935
125JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89741934
126BCOR_27268052_Chip-Seq_Bcells_Human0.87215933
127PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86709348

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell3.72667131
2MP0002139_abnormal_hepatobiliary_system3.43075727
3MP0005360_urolithiasis3.38621069
4MP0005058_abnormal_lysosome_morphology3.30906684
5MP0008438_abnormal_cutaneous_collagen3.20408216
6MP0005365_abnormal_bile_salt2.90691228
7MP0003191_abnormal_cellular_cholesterol2.76224604
8MP0003705_abnormal_hypodermis_morpholog2.73684585
9MP0003172_abnormal_lysosome_physiology2.41955863
10MP0003300_gastrointestinal_ulcer2.39245879
11MP0005085_abnormal_gallbladder_physiolo2.33804296
12MP0003252_abnormal_bile_duct2.25793768
13MP0003303_peritoneal_inflammation2.25435919
14MP0003436_decreased_susceptibility_to2.18324280
15MP0008875_abnormal_xenobiotic_pharmacok2.06840068
16MP0010329_abnormal_lipoprotein_level2.02329134
17MP0001835_abnormal_antigen_presentation1.78941866
18MP0006082_CNS_inflammation1.78101987
19MP0005464_abnormal_platelet_physiology1.74887735
20MP0005083_abnormal_biliary_tract1.69360368
21MP0002419_abnormal_innate_immunity1.65450998
22MP0003279_aneurysm1.63926022
23MP0001542_abnormal_bone_strength1.59659732
24MP0003566_abnormal_cell_adhesion1.58060386
25MP0000604_amyloidosis1.57896880
26MP0000609_abnormal_liver_physiology1.57893749
27MP0000685_abnormal_immune_system1.56615010
28MP0001533_abnormal_skeleton_physiology1.56575652
29MP0005670_abnormal_white_adipose1.56286779
30MP0003183_abnormal_peptide_metabolism1.54920200
31MP0006054_spinal_hemorrhage1.48732782
32MP0005164_abnormal_response_to1.43811290
33MP0005387_immune_system_phenotype1.43747115
34MP0001790_abnormal_immune_system1.43747115
35MP0004883_abnormal_blood_vessel1.42057267
36MP0005275_abnormal_skin_tensile1.39211201
37MP0000858_altered_metastatic_potential1.36543891
38MP0003828_pulmonary_edema1.31184955
39MP0003195_calcinosis1.29423051
40MP0008469_abnormal_protein_level1.29296355
41MP0005332_abnormal_amino_acid1.29127255
42MP0001666_abnormal_nutrient_absorption1.29044981
43MP0005025_abnormal_response_to1.28906098
44MP0003763_abnormal_thymus_physiology1.28534874
45MP0004947_skin_inflammation1.28343202
46MP0003329_amyloid_beta_deposits1.28098760
47MP0002118_abnormal_lipid_homeostasis1.27699198
48MP0001958_emphysema1.27015608
49MP0003724_increased_susceptibility_to1.26212823
50MP0005000_abnormal_immune_tolerance1.24170377
51MP0009643_abnormal_urine_homeostasis1.23737823
52MP0005023_abnormal_wound_healing1.23308400
53MP0005319_abnormal_enzyme/_coenzyme1.21908402
54MP0009384_cardiac_valve_regurgitation1.21135024
55MP0002254_reproductive_system_inflammat1.20275080
56MP0002138_abnormal_hepatobiliary_system1.18781882
57MP0005257_abnormal_intraocular_pressure1.18774672
58MP0003075_altered_response_to1.18494334
59MP0008260_abnormal_autophagy1.17856660
60MP0002452_abnormal_antigen_presenting1.16901668
61MP0001845_abnormal_inflammatory_respons1.16855654
62MP0001800_abnormal_humoral_immune1.13950888
63MP0003806_abnormal_nucleotide_metabolis1.12485972
64MP0002998_abnormal_bone_remodeling1.11616720
65MP0009278_abnormal_bone_marrow1.11071103
66MP0004272_abnormal_basement_membrane1.08769677
67MP0002877_abnormal_melanocyte_morpholog1.08271485
68MP0005451_abnormal_body_composition1.06722874
69MP0000598_abnormal_liver_morphology1.05757055
70MP0000343_altered_response_to1.04767214
71MP0002933_joint_inflammation1.04560107
72MP0009785_altered_susceptibility_to1.04098708
73MP0002723_abnormal_immune_serum1.03733143
74MP0002166_altered_tumor_susceptibility1.03097585
75MP0001851_eye_inflammation1.03051280
76MP0001348_abnormal_lacrimal_gland1.01716271
77MP0001853_heart_inflammation0.98536990
78MP0005310_abnormal_salivary_gland0.98081921
79MP0002928_abnormal_bile_duct0.97007511
80MP0000249_abnormal_blood_vessel0.94806011
81MP0009764_decreased_sensitivity_to0.93782225
82MP0000716_abnormal_immune_system0.93279617
83MP0004510_myositis0.93257448
84MP0005584_abnormal_enzyme/coenzyme_acti0.92828520
85MP0002405_respiratory_system_inflammati0.92694974
86MP0003795_abnormal_bone_structure0.92443363
87MP0005595_abnormal_vascular_smooth0.92237174
88MP0003045_fibrosis0.92177742
89MP0003690_abnormal_glial_cell0.91617005
90MP0001819_abnormal_immune_cell0.91537712
91MP0004130_abnormal_muscle_cell0.91419626
92MP0002420_abnormal_adaptive_immunity0.91063038
93MP0004019_abnormal_vitamin_homeostasis0.89893708
94MP0002295_abnormal_pulmonary_circulatio0.89835301
95MP0009763_increased_sensitivity_to0.89687608
96MP0004185_abnormal_adipocyte_glucose0.89027864
97MP0004858_abnormal_nervous_system0.88361949
98MP0005671_abnormal_response_to0.88145033
99MP0005166_decreased_susceptibility_to0.88012067
100MP0005390_skeleton_phenotype0.86797982
101MP0010307_abnormal_tumor_latency0.86741315
102MP0008004_abnormal_stomach_pH0.86511968
103MP0001849_ear_inflammation0.86417802
104MP0005503_abnormal_tendon_morphology0.86107796
105MP0003866_abnormal_defecation0.85026367
106MP0002896_abnormal_bone_mineralization0.84307406
107MP0002136_abnormal_kidney_physiology0.83607194
108MP0003656_abnormal_erythrocyte_physiolo0.83105277
109MP0008961_abnormal_basal_metabolism0.82987755
110MP0005220_abnormal_exocrine_pancreas0.82707435
111MP0003453_abnormal_keratinocyte_physiol0.82700667
112MP0010352_gastrointestinal_tract_polyps0.82655465
113MP0002148_abnormal_hypersensitivity_rea0.82439586
114MP0001915_intracranial_hemorrhage0.80132125
115MP0002168_other_aberrant_phenotype0.79660750
116MP0000465_gastrointestinal_hemorrhage0.79611378
117MP0010155_abnormal_intestine_physiology0.78125643
118MP0003091_abnormal_cell_migration0.77817015
119MP0002060_abnormal_skin_morphology0.77779188
120MP0000767_abnormal_smooth_muscle0.77730571
121MP0009333_abnormal_splenocyte_physiolog0.76980283
122MP0005666_abnormal_adipose_tissue0.76548151
123MP0003448_altered_tumor_morphology0.75840747
124MP0001756_abnormal_urination0.75632805
125MP0010368_abnormal_lymphatic_system0.73936634
126MP0000920_abnormal_myelination0.73289972
127MP0001873_stomach_inflammation0.72306076
128MP0002398_abnormal_bone_marrow0.71071266
129MP0005508_abnormal_skeleton_morphology0.70545214
130MP0001663_abnormal_digestive_system0.70388360
131MP0008874_decreased_physiological_sensi0.68538085
132MP0003879_abnormal_hair_cell0.67747783
133MP0005397_hematopoietic_system_phenotyp0.66896027

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)4.65217822
2Dysostosis multiplex (HP:0000943)4.33466733
3Mucopolysacchariduria (HP:0008155)4.14786394
4Urinary glycosaminoglycan excretion (HP:0003541)4.14786394
5Complement deficiency (HP:0004431)4.10882430
6Deep venous thrombosis (HP:0002625)3.91117721
7Abnormality of mucopolysaccharide metabolism (HP:0011020)3.89790746
8Abnormality of polysaccharide metabolism (HP:0011012)3.89790746
9Abnormality of glycosaminoglycan metabolism (HP:0004371)3.89790746
10Increased cerebral lipofuscin (HP:0011813)3.80124606
11Glomerulonephritis (HP:0000099)3.60754432
12Xanthomatosis (HP:0000991)3.57312729
13Vacuolated lymphocytes (HP:0001922)3.50496868
14Abnormality of complement system (HP:0005339)3.43068481
15Cerebral aneurysm (HP:0004944)3.24629284
16Increased neuronal autofluorescent lipopigment (HP:0002074)3.23275711
17Protrusio acetabuli (HP:0003179)3.14648967
18Myocardial infarction (HP:0001658)3.12250997
19Recurrent gram-negative bacterial infections (HP:0005420)3.11152614
20Myositis (HP:0100614)3.08155432
21Abnormality of glycosphingolipid metabolism (HP:0004343)2.95157260
22Abnormality of glycolipid metabolism (HP:0010969)2.95157260
23Abnormality of liposaccharide metabolism (HP:0010968)2.95157260
24Peritonitis (HP:0002586)2.91347459
25Eczematoid dermatitis (HP:0000976)2.88098903
26Cervical subluxation (HP:0003308)2.84111136
27Abnormality of aromatic amino acid family metabolism (HP:0004338)2.84005073
28Orchitis (HP:0100796)2.81236120
29Abnormality of monocarboxylic acid metabolism (HP:0010996)2.80862866
30Abnormality of the common coagulation pathway (HP:0010990)2.76992888
31Joint hemorrhage (HP:0005261)2.76883340
32Mitral stenosis (HP:0001718)2.73611182
33Asymmetric septal hypertrophy (HP:0001670)2.72865140
34Elevated erythrocyte sedimentation rate (HP:0003565)2.69252053
35Nephritis (HP:0000123)2.66155743
36Hyperlipoproteinemia (HP:0010980)2.63151125
37Premature rupture of membranes (HP:0001788)2.63110004
38Recurrent abscess formation (HP:0002722)2.59168137
39Intrahepatic cholestasis (HP:0001406)2.56834089
40Loss of speech (HP:0002371)2.54023030
41Recurrent bacterial skin infections (HP:0005406)2.52769942
42Nasal polyposis (HP:0100582)2.50609111
43Abnormality of the nasal mucosa (HP:0000433)2.41869387
44Hypoglycemic coma (HP:0001325)2.40055032
45Spondylolisthesis (HP:0003302)2.37911534
46Hypercholesterolemia (HP:0003124)2.37554047
47Axonal loss (HP:0003447)2.37507798
48Atrophic scars (HP:0001075)2.34524343
49Prolonged partial thromboplastin time (HP:0003645)2.34509665
50Optic neuritis (HP:0100653)2.34220191
51Retrobulbar optic neuritis (HP:0100654)2.34220191
52Aortic aneurysm (HP:0004942)2.28526279
53Hypoalphalipoproteinemia (HP:0003233)2.25331527
54Abnormality of glutamine family amino acid metabolism (HP:0010902)2.23994353
55Vertebral compression fractures (HP:0002953)2.23639649
56Aortic dissection (HP:0002647)2.22918046
57Abnormality of the intrinsic pathway (HP:0010989)2.21654981
58Hand muscle atrophy (HP:0009130)2.21221455
59Thoracic kyphosis (HP:0002942)2.20583753
60Blue sclerae (HP:0000592)2.19977722
61Emphysema (HP:0002097)2.19472581
62Genu recurvatum (HP:0002816)2.18765219
63Ovoid vertebral bodies (HP:0003300)2.18391932
64Ankle contracture (HP:0006466)2.18119693
65Gingival bleeding (HP:0000225)2.17390653
66Gingivitis (HP:0000230)2.17032887
67Obstructive sleep apnea (HP:0002870)2.16491997
68Skin nodule (HP:0200036)2.15154733
69Amyloidosis (HP:0011034)2.13207310
70Retinal atrophy (HP:0001105)2.13055179
71Gastrointestinal infarctions (HP:0005244)2.12969160
72Joint stiffness (HP:0001387)2.12821049
73Abnormality of macrophages (HP:0004311)2.10437005
74Thin bony cortex (HP:0002753)2.10046189
75Hematochezia (HP:0002573)2.08848152
76Stomatitis (HP:0010280)2.07254224
77Ketosis (HP:0001946)2.06945868
78Neurofibrillary tangles (HP:0002185)2.06939501
79Fragile skin (HP:0001030)2.06870184
80J-shaped sella turcica (HP:0002680)2.04952510
81Recurrent fungal infections (HP:0002841)2.04650995
82Distal upper limb amyotrophy (HP:0007149)2.02105435
83Upper limb amyotrophy (HP:0009129)2.02105435
84Recurrent skin infections (HP:0001581)2.01604397
85Interstitial pulmonary disease (HP:0006530)2.01541336
86Wormian bones (HP:0002645)2.01221632
87Menorrhagia (HP:0000132)1.99414487
88Pustule (HP:0200039)1.98839631
89Bladder diverticulum (HP:0000015)1.98816920
90Autoimmune thrombocytopenia (HP:0001973)1.98080844
91Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.97283469
92Pulmonary infiltrates (HP:0002113)1.96776833
93Aneurysm (HP:0002617)1.96374953
94Recurrent cutaneous fungal infections (HP:0011370)1.96301134
95Chronic mucocutaneous candidiasis (HP:0002728)1.96301134
96Mitral valve prolapse (HP:0001634)1.95279301
97Late onset (HP:0003584)1.95223100
98Abnormal platelet function (HP:0011869)1.94747956
99Impaired platelet aggregation (HP:0003540)1.94747956
100Epidermoid cyst (HP:0200040)1.94242199
101Esophageal varix (HP:0002040)1.93916870
102Hypolipoproteinemia (HP:0010981)1.93911575
103Follicular hyperkeratosis (HP:0007502)1.93512228
104Abnormality of the lumbar spine (HP:0100712)1.93144856
105Osteolytic defects of the hand bones (HP:0009699)1.91761924
106Osteolytic defects of the phalanges of the hand (HP:0009771)1.91761924
107Broad face (HP:0000283)1.91626361
108Disproportionate tall stature (HP:0001519)1.90401812
109Hemoptysis (HP:0002105)1.89879219
110Purpura (HP:0000979)1.88853487
111Hemorrhage of the eye (HP:0011885)1.87315598
112Beaking of vertebral bodies (HP:0004568)1.87009477
113Abnormality of the thoracic spine (HP:0100711)1.86287053
114Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.86017593
115Arterial tortuosity (HP:0005116)1.85950126
116Increased variability in muscle fiber diameter (HP:0003557)1.85677248
117Soft skin (HP:0000977)1.85645911
118Hypobetalipoproteinemia (HP:0003563)1.85537755
119Mediastinal lymphadenopathy (HP:0100721)1.85428286
120Pathologic fracture (HP:0002756)1.84973540
121Broad metatarsal (HP:0001783)1.84636797
122Abnormality of sulfur amino acid metabolism (HP:0004339)1.84056676
123Increased IgE level (HP:0003212)1.83724040
124Cellulitis (HP:0100658)1.83609077
125Protuberant abdomen (HP:0001538)1.83402779
126Increased CSF protein (HP:0002922)1.83067171
127Slender build (HP:0001533)1.82927602
128Vascular tortuosity (HP:0004948)1.82028005
129Dilatation of the ascending aorta (HP:0005111)1.81295336
130Shallow orbits (HP:0000586)1.80761459
131Global brain atrophy (HP:0002283)1.80283897
132Spontaneous hematomas (HP:0007420)1.80254121
133Tetraparesis (HP:0002273)1.80085210
134Mitral regurgitation (HP:0001653)1.79695724
135Vasculitis (HP:0002633)1.78974957
136Aortic regurgitation (HP:0001659)1.78842337
137Colitis (HP:0002583)1.78738190
138Polycythemia (HP:0001901)1.78587503
139Periodontitis (HP:0000704)1.77750357
140Striae distensae (HP:0001065)1.77739330
141Increased connective tissue (HP:0009025)1.74155627
142Spinal rigidity (HP:0003306)1.72139383
143Epistaxis (HP:0000421)1.70309567
144Abnormal delayed hypersensitivity skin test (HP:0002963)1.70051765
145Flared iliac wings (HP:0002869)1.68951177
146Cerebral inclusion bodies (HP:0100314)1.68534754
147Joint laxity (HP:0001388)1.68092097

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.87504411
2TRIB34.10079858
3PKN22.97582648
4MAP4K12.63967768
5SIK12.63480942
6TGFBR22.60386003
7PRPF4B2.39927186
8TAOK32.21323510
9TYK22.16906416
10FGFR41.96420251
11TBK11.87807499
12RIPK11.86323535
13EPHB11.84832992
14PTK61.83544806
15EEF2K1.81822240
16JAK31.70210652
17ZAP701.62535883
18PRKD21.62292045
19JAK11.61404269
20CAMK1D1.60430702
21CSF1R1.60034401
22FLT31.58371903
23TTN1.56969937
24CDC42BPA1.55845454
25MAP3K101.55448614
26KIT1.54725621
27BCKDK1.53087444
28MST1R1.42820958
29TAOK11.38039929
30MAP3K131.36297163
31SCYL21.34859910
32MAP2K31.33293248
33LRRK21.32095975
34BLK1.32075353
35CAMK1G1.29478401
36MARK21.28857275
37PDGFRA1.25297892
38IRAK31.24486106
39PAK41.22700527
40MYLK1.20715152
41TNK21.20367797
42BTK1.19330906
43CSK1.19089886
44INSRR1.16162630
45MAPK151.13620869
46TAOK21.13246450
47STK101.13008780
48BMX1.10838550
49TESK11.10185851
50GRK71.10173039
51JAK21.08751401
52MAPK71.04585620
53STK381.01981370
54HCK1.00935280
55GRK60.93906686
56PTK20.93070762
57KDR0.90087832
58ICK0.89356027
59NEK90.85494309
60EPHA30.85124285
61IRAK40.83847176
62DYRK1B0.83732770
63MAP3K60.81185492
64TXK0.80840635
65MAPK120.80111575
66MAP3K30.79489160
67ITK0.79020015
68SYK0.76725871
69IKBKE0.76141426
70IRAK20.74703267
71MOS0.74685172
72PIK3CG0.73730912
73TESK20.73250820
74SMG10.72402743
75FGFR30.71292890
76PAK20.71222337
77IKBKB0.70488965
78EPHB20.67443255
79MET0.66816076
80RPS6KC10.66733778
81RPS6KL10.66733778
82MAP3K140.66229035
83CDK60.65503092
84MTOR0.65206635
85LCK0.64380027
86FES0.63891489
87DDR20.63084182
88FGR0.62425659
89CAMKK10.62013487
90RPS6KA60.60967420
91PRKCH0.60467162
92RPS6KA40.60052488
93MAP3K10.59688030
94CHUK0.59244609
95CDK120.56916869
96MAPK110.55967963
97PDPK10.55926307
98KSR20.55732310
99PDK10.55191379
100LYN0.54085741
101RIPK40.53077008
102HIPK20.52514802
103RET0.51980913
104SIK20.51818169
105MARK30.51404608
106MAP3K110.50841135
107MATK0.50612894
108RPS6KA20.49945765
109EGFR0.49463126
110SGK30.49273112
111PDK30.48396639
112PDK40.48396639
113PTK2B0.47542973
114PDGFRB0.47428343
115PIM20.47334163
116PRKD10.47277548
117IRAK10.46861155
118MAP2K60.46859000
119PIM10.46824038
120SIK30.46737576
121NTRK10.46405507
122FYN0.45903735
123GRK50.45856079
124DAPK20.45806333
125IGF1R0.45796899
126TRPM70.43325441
127CAMKK20.41788941
128MAP3K70.41010612
129PRKD30.40978496
130TEC0.40765070
131MAPK40.40377002
132ABL10.39032867
133PRKG20.38449960

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.28824138
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.16272783
3Complement and coagulation cascades_Homo sapiens_hsa046102.77927464
4Nitrogen metabolism_Homo sapiens_hsa009102.68618604
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.66687860
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.35196608
7Lysosome_Homo sapiens_hsa041422.25449478
8Caffeine metabolism_Homo sapiens_hsa002322.03546247
9Fatty acid degradation_Homo sapiens_hsa000712.01330691
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.00171930
11* Other glycan degradation_Homo sapiens_hsa005111.85509466
12Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84918175
13Tryptophan metabolism_Homo sapiens_hsa003801.79724220
14Arginine biosynthesis_Homo sapiens_hsa002201.72033408
15PPAR signaling pathway_Homo sapiens_hsa033201.70376844
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.63424438
17Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.53438847
18Fatty acid metabolism_Homo sapiens_hsa012121.42031391
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38108251
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.37335466
21ABC transporters_Homo sapiens_hsa020101.35054574
22Leishmaniasis_Homo sapiens_hsa051401.33067283
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32048948
24Allograft rejection_Homo sapiens_hsa053301.31644173
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28347881
26Starch and sucrose metabolism_Homo sapiens_hsa005001.28156966
27Selenocompound metabolism_Homo sapiens_hsa004501.27673402
28Graft-versus-host disease_Homo sapiens_hsa053321.26762462
29Autoimmune thyroid disease_Homo sapiens_hsa053201.24244112
30Osteoclast differentiation_Homo sapiens_hsa043801.22610317
31Bile secretion_Homo sapiens_hsa049761.21646633
32Histidine metabolism_Homo sapiens_hsa003401.19421661
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15265188
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14734745
35Peroxisome_Homo sapiens_hsa041461.11595788
36Fat digestion and absorption_Homo sapiens_hsa049751.05341925
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04525321
38Chemokine signaling pathway_Homo sapiens_hsa040621.04394230
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04127618
40Malaria_Homo sapiens_hsa051441.03872309
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.02785304
42T cell receptor signaling pathway_Homo sapiens_hsa046601.02726325
43Lysine degradation_Homo sapiens_hsa003101.02442028
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99161521
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98606826
46Pertussis_Homo sapiens_hsa051330.98151659
47Hepatitis C_Homo sapiens_hsa051600.98096100
48Antigen processing and presentation_Homo sapiens_hsa046120.97638858
49Rheumatoid arthritis_Homo sapiens_hsa053230.97625106
50NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97520683
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.97269454
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95090845
53Chemical carcinogenesis_Homo sapiens_hsa052040.94228355
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93786639
55Insulin resistance_Homo sapiens_hsa049310.93307688
56beta-Alanine metabolism_Homo sapiens_hsa004100.92972539
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91973068
58VEGF signaling pathway_Homo sapiens_hsa043700.91847102
59Propanoate metabolism_Homo sapiens_hsa006400.90910240
60Notch signaling pathway_Homo sapiens_hsa043300.90361386
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.89783032
62B cell receptor signaling pathway_Homo sapiens_hsa046620.89575568
63Viral myocarditis_Homo sapiens_hsa054160.89041846
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85824904
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84197011
66Toxoplasmosis_Homo sapiens_hsa051450.84023120
67Renin-angiotensin system_Homo sapiens_hsa046140.83836613
68Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82287542
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82274265
70Hepatitis B_Homo sapiens_hsa051610.81976017
71Tuberculosis_Homo sapiens_hsa051520.81870369
72Legionellosis_Homo sapiens_hsa051340.81709658
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.81594200
74African trypanosomiasis_Homo sapiens_hsa051430.81060043
75Asthma_Homo sapiens_hsa053100.80571996
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.80540034
77Endocytosis_Homo sapiens_hsa041440.80226192
78GnRH signaling pathway_Homo sapiens_hsa049120.80099293
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79532299
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79431101
81Pentose phosphate pathway_Homo sapiens_hsa000300.79114067
82Type I diabetes mellitus_Homo sapiens_hsa049400.78207452
83Salmonella infection_Homo sapiens_hsa051320.77820264
84Primary immunodeficiency_Homo sapiens_hsa053400.76779484
85Galactose metabolism_Homo sapiens_hsa000520.76207707
86Amoebiasis_Homo sapiens_hsa051460.76170703
87Prolactin signaling pathway_Homo sapiens_hsa049170.75307087
88Prion diseases_Homo sapiens_hsa050200.72999810
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.72527477
90Carbon metabolism_Homo sapiens_hsa012000.72364367
91Sulfur metabolism_Homo sapiens_hsa009200.71780264
92Pancreatic cancer_Homo sapiens_hsa052120.71724494
93Renal cell carcinoma_Homo sapiens_hsa052110.71346074
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71155558
95Phenylalanine metabolism_Homo sapiens_hsa003600.70664437
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.69265847
97Vitamin digestion and absorption_Homo sapiens_hsa049770.68257058
98Pyruvate metabolism_Homo sapiens_hsa006200.67845041
99Glycerolipid metabolism_Homo sapiens_hsa005610.67838135
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66964827
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66760152
102mTOR signaling pathway_Homo sapiens_hsa041500.66396417
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66330486
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65924610
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65530858
106Non-small cell lung cancer_Homo sapiens_hsa052230.65319235
107Butanoate metabolism_Homo sapiens_hsa006500.65182474
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64321695
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64309799
110Chronic myeloid leukemia_Homo sapiens_hsa052200.64039486
111Biosynthesis of amino acids_Homo sapiens_hsa012300.63766504
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63150974
113Phagosome_Homo sapiens_hsa041450.62445194
114Sulfur relay system_Homo sapiens_hsa041220.61155354
115Estrogen signaling pathway_Homo sapiens_hsa049150.60385134
116Bladder cancer_Homo sapiens_hsa052190.58894113
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58027700
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.57659482
119ECM-receptor interaction_Homo sapiens_hsa045120.56274882
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.56024940
121Choline metabolism in cancer_Homo sapiens_hsa052310.55721422
122Measles_Homo sapiens_hsa051620.54494499
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52754509
124N-Glycan biosynthesis_Homo sapiens_hsa005100.52268090
125MAPK signaling pathway_Homo sapiens_hsa040100.51825165
126Rap1 signaling pathway_Homo sapiens_hsa040150.51239035
127Dorso-ventral axis formation_Homo sapiens_hsa043200.50680483
128Folate biosynthesis_Homo sapiens_hsa007900.50442109
129Herpes simplex infection_Homo sapiens_hsa051680.49766058
130Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48906351
131Retinol metabolism_Homo sapiens_hsa008300.48064935
132Apoptosis_Homo sapiens_hsa042100.47879453
133FoxO signaling pathway_Homo sapiens_hsa040680.47725632
134Focal adhesion_Homo sapiens_hsa045100.47657843
135Tyrosine metabolism_Homo sapiens_hsa003500.47394805
136Endometrial cancer_Homo sapiens_hsa052130.47157865
137Acute myeloid leukemia_Homo sapiens_hsa052210.46932879
138Small cell lung cancer_Homo sapiens_hsa052220.46660945
139Sphingolipid metabolism_Homo sapiens_hsa006000.46495411
140Vascular smooth muscle contraction_Homo sapiens_hsa042700.45730774
141Protein digestion and absorption_Homo sapiens_hsa049740.43839674
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43654777
143Fructose and mannose metabolism_Homo sapiens_hsa000510.43588914
144Type II diabetes mellitus_Homo sapiens_hsa049300.43291770
145TNF signaling pathway_Homo sapiens_hsa046680.43118889
146Platelet activation_Homo sapiens_hsa046110.41694951
147Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41521626
148Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40407068
149Influenza A_Homo sapiens_hsa051640.39285992
150Shigellosis_Homo sapiens_hsa051310.38630660
151Proteoglycans in cancer_Homo sapiens_hsa052050.38580675
152Central carbon metabolism in cancer_Homo sapiens_hsa052300.38495878
153Fatty acid biosynthesis_Homo sapiens_hsa000610.38469750
154Hematopoietic cell lineage_Homo sapiens_hsa046400.37711189
155Jak-STAT signaling pathway_Homo sapiens_hsa046300.37505344

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