MAN2C1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.41582604
2presynaptic membrane assembly (GO:0097105)4.44170238
3postsynaptic membrane organization (GO:0001941)4.39566181
4positive regulation of gamma-delta T cell activation (GO:0046645)4.16740518
5positive regulation of protein kinase C signaling (GO:0090037)4.08140701
6presynaptic membrane organization (GO:0097090)3.94772759
7response to muramyl dipeptide (GO:0032495)3.80275382
8short-term memory (GO:0007614)3.77499303
9metanephric nephron tubule development (GO:0072234)3.55491925
10metanephric tubule development (GO:0072170)3.55491925
11neuronal action potential propagation (GO:0019227)3.48729221
12* mannose metabolic process (GO:0006013)3.48599535
13facial nerve structural organization (GO:0021612)3.47161496
14regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.46558543
15regulation of gamma-delta T cell activation (GO:0046643)3.42990848
16regulation of pigment cell differentiation (GO:0050932)3.35842169
17antigen processing and presentation of endogenous antigen (GO:0019883)3.34002088
18metanephric nephron epithelium development (GO:0072243)3.32855251
19regulation of gamma-delta T cell differentiation (GO:0045586)3.26161239
20positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.16272811
21metanephric epithelium development (GO:0072207)3.11783153
22germinal center formation (GO:0002467)3.11435045
23positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.02722378
24gamma-aminobutyric acid transport (GO:0015812)3.00598514
25response to peptidoglycan (GO:0032494)3.00178310
26negative regulation of cell killing (GO:0031342)2.95140040
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.95140040
28detection of bacterium (GO:0016045)2.93135207
29regulation of protein kinase C signaling (GO:0090036)2.92565156
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.91918334
31cranial nerve structural organization (GO:0021604)2.91653617
32positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.90895922
33response to laminar fluid shear stress (GO:0034616)2.87904080
34detection of other organism (GO:0098543)2.87722092
35T cell selection (GO:0045058)2.86380140
36positive regulation of synaptic transmission, GABAergic (GO:0032230)2.86314555
37antigen processing and presentation via MHC class Ib (GO:0002475)2.85263808
38positive regulation of histone deacetylation (GO:0031065)2.84576235
39negative thymic T cell selection (GO:0045060)2.84174352
40nephron epithelium development (GO:0072009)2.83897900
41calcium ion import (GO:0070509)2.81998068
42negative regulation of granulocyte differentiation (GO:0030853)2.81629339
43positive regulation by symbiont of host defense response (GO:0052509)2.79895208
44modulation by symbiont of host defense response (GO:0052031)2.79895208
45modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.79895208
46modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.79895208
47positive regulation by organism of defense response of other organism involved in symbiotic interact2.79895208
48modulation by symbiont of host immune response (GO:0052553)2.79895208
49positive thymic T cell selection (GO:0045059)2.79278264
50androgen biosynthetic process (GO:0006702)2.78982272
51semaphorin-plexin signaling pathway (GO:0071526)2.76841642
52glycine transport (GO:0015816)2.75440903
53macrophage activation involved in immune response (GO:0002281)2.70097867
54negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.69929903
55positive regulation of Rap GTPase activity (GO:0032854)2.69539573
56regulation of protein kinase A signaling (GO:0010738)2.69254682
57NIK/NF-kappaB signaling (GO:0038061)2.69254395
58negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.69136755
59negative regulation of cell size (GO:0045792)2.67990909
60endothelium development (GO:0003158)2.64304981
61long-term memory (GO:0007616)2.63831748
62positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.62613373
63mature B cell differentiation (GO:0002335)2.61943063
64regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.59140785
65ionotropic glutamate receptor signaling pathway (GO:0035235)2.58942568
66negative T cell selection (GO:0043383)2.58854692
67activation of JUN kinase activity (GO:0007257)2.55971559
68positive regulation of dendritic spine development (GO:0060999)2.55842917
69regulation of extracellular matrix disassembly (GO:0010715)2.55682330
70central nervous system myelination (GO:0022010)2.53873389
71axon ensheathment in central nervous system (GO:0032291)2.53873389
72mesenchymal cell differentiation involved in renal system development (GO:2001012)2.53381435
73mesenchymal cell differentiation involved in kidney development (GO:0072161)2.53381435
74protein heterotetramerization (GO:0051290)2.52998546
75regulation of type I interferon-mediated signaling pathway (GO:0060338)2.52778194
76leukocyte aggregation (GO:0070486)2.52291791
77positive regulation of CREB transcription factor activity (GO:0032793)2.52254030
78negative regulation of execution phase of apoptosis (GO:1900118)2.50277086
79positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.48145033
80negative regulation of cardiac muscle hypertrophy (GO:0010614)2.46834735
81melanin metabolic process (GO:0006582)2.46826144
82histone H4 deacetylation (GO:0070933)2.46395009
83G-protein coupled receptor internalization (GO:0002031)2.46331718
84cyclic nucleotide catabolic process (GO:0009214)2.44356507
85left/right pattern formation (GO:0060972)2.44114765
86cAMP catabolic process (GO:0006198)2.43940087
87endothelial cell chemotaxis (GO:0035767)2.42795798
88central nervous system neuron axonogenesis (GO:0021955)2.42621228
89cranial nerve morphogenesis (GO:0021602)2.42448114
90import into cell (GO:0098657)2.40768255
91detection of external biotic stimulus (GO:0098581)2.40215377
92positive regulation of protein deacetylation (GO:0090312)2.39508071
93cell differentiation involved in metanephros development (GO:0072202)2.39238954
94histone H3 deacetylation (GO:0070932)2.38929482
95regulation of histone H3-K27 methylation (GO:0061085)2.38550842
96regulation of dendritic cell antigen processing and presentation (GO:0002604)2.38151064
97positive T cell selection (GO:0043368)2.37890424
98negative regulation of leukocyte chemotaxis (GO:0002689)2.37060601
99embryonic process involved in female pregnancy (GO:0060136)2.36973197
100negative regulation of fatty acid transport (GO:2000192)2.36773869
101adaptation of signaling pathway (GO:0023058)2.36756258
102membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.35538254
103organ growth (GO:0035265)2.34902848
104regulation of leukocyte degranulation (GO:0043300)2.34426570
105tolerance induction (GO:0002507)2.34261294
106negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.33273589
107regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.33230296
108regulation of ARF GTPase activity (GO:0032312)2.32988219
109regulation of myeloid leukocyte mediated immunity (GO:0002886)2.31895840
110activation of MAPKKK activity (GO:0000185)2.31880290
111regulation of p38MAPK cascade (GO:1900744)2.31838792
112amino acid import (GO:0043090)2.31610482
113negative regulation of innate immune response (GO:0045824)2.31499981
114developmental pigmentation (GO:0048066)2.31160022
115omega-hydroxylase P450 pathway (GO:0097267)2.30998808
116regulation of necroptotic process (GO:0060544)2.30040973
117B cell receptor signaling pathway (GO:0050853)2.29685711
118apoptotic process involved in morphogenesis (GO:0060561)2.29537758
119modulation by symbiont of host cellular process (GO:0044068)2.28074794
120response to fluid shear stress (GO:0034405)2.27760368
121stress fiber assembly (GO:0043149)2.27757814
122negative regulation of myotube differentiation (GO:0010832)2.27553772
123positive regulation of cellular amide metabolic process (GO:0034250)2.27224760
124regulation of timing of cell differentiation (GO:0048505)2.26341633
125histone H3-K36 demethylation (GO:0070544)2.26180645
126positive regulation of receptor recycling (GO:0001921)2.25795488
127nephron tubule development (GO:0072080)2.25752181
128epithelial cell differentiation involved in prostate gland development (GO:0060742)2.25380772
129cornea development in camera-type eye (GO:0061303)2.24879522
130negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.24780064
131positive regulation of antigen processing and presentation (GO:0002579)2.24488322
132positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.24305841
133modulation by virus of host process (GO:0019054)2.23517334
134adherens junction assembly (GO:0034333)2.22578015
135negative regulation of leukocyte mediated immunity (GO:0002704)2.22395984
136negative regulation of toll-like receptor signaling pathway (GO:0034122)2.21702370
137regulation of interferon-beta biosynthetic process (GO:0045357)2.21476604
138signal complex assembly (GO:0007172)2.21037194
139negative regulation of interleukin-12 production (GO:0032695)2.20719779
140regulation of axon extension involved in axon guidance (GO:0048841)2.20714064
141negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.20685436
142positive regulation of Cdc42 GTPase activity (GO:0043089)2.20316735
143positive regulation of cholesterol efflux (GO:0010875)2.19011197
144focal adhesion assembly (GO:0048041)2.18788033
145cell-substrate adherens junction assembly (GO:0007045)2.18788033
146detection of biotic stimulus (GO:0009595)2.18106689
147insulin-like growth factor receptor signaling pathway (GO:0048009)2.17758905
148neuron remodeling (GO:0016322)2.17351948
149regulation of T-helper 2 cell differentiation (GO:0045628)2.16978472
150negative regulation of synaptic transmission, GABAergic (GO:0032229)2.16770898
151negative regulation of lymphocyte mediated immunity (GO:0002707)2.16719109
152regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.16391752
153L-amino acid import (GO:0043092)2.16256926
154cerebellar Purkinje cell layer development (GO:0021680)2.16233700
155central nervous system projection neuron axonogenesis (GO:0021952)2.16011706
156positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.15712813
157adenosine receptor signaling pathway (GO:0001973)2.14945429
158regulation of mast cell degranulation (GO:0043304)2.14752623
159Golgi to endosome transport (GO:0006895)2.14350438
160RNA destabilization (GO:0050779)2.14238630
161cell-cell junction maintenance (GO:0045217)2.14117734
162regulation of monocyte differentiation (GO:0045655)2.13431947
163cellular extravasation (GO:0045123)2.13396745
164regulation of glutamate receptor signaling pathway (GO:1900449)2.12935189
165negative regulation of muscle hypertrophy (GO:0014741)2.11909717
166regulation of Rap GTPase activity (GO:0032317)2.11174735
167melanin biosynthetic process (GO:0042438)2.11013297
168cellular response to epinephrine stimulus (GO:0071872)2.10720058
169barbed-end actin filament capping (GO:0051016)2.10054377
170membrane depolarization during action potential (GO:0086010)2.08331717
171regulation of antigen processing and presentation (GO:0002577)2.07978692
172positive regulation of calcium ion import (GO:0090280)2.07920319
173regulation of cytokine production involved in inflammatory response (GO:1900015)2.07769364
174regulation of synaptic transmission, GABAergic (GO:0032228)2.07673621
175vocalization behavior (GO:0071625)2.06632061
176response to folic acid (GO:0051593)2.05867847
177forebrain neuron differentiation (GO:0021879)2.04517150
178renal tubule development (GO:0061326)2.03252559
179oligodendrocyte differentiation (GO:0048709)2.00507797
180polyol transport (GO:0015791)2.00205043
181phospholipid scrambling (GO:0017121)1.99386127
182thymic T cell selection (GO:0045061)1.99212599
183regulation of ARF protein signal transduction (GO:0032012)1.99160147
184antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.97605753
185antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.97605753
186autophagic vacuole fusion (GO:0000046)1.96820393

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.21288661
2MYC_22102868_ChIP-Seq_BL_Human2.65839321
3* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.56337155
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.48646704
5ELK3_25401928_ChIP-Seq_HUVEC_Human2.46634209
6IKZF1_21737484_ChIP-ChIP_HCT116_Human2.32874017
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.30738956
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.29547549
9DROSHA_22980978_ChIP-Seq_HELA_Human2.24232261
10EZH2_27294783_Chip-Seq_ESCs_Mouse2.21363205
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20749786
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16749091
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16122369
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15820983
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14682771
16GBX2_23144817_ChIP-Seq_PC3_Human2.13276415
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12680433
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12680433
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11775161
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.10102729
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.05827849
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03573765
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.03410491
24STAT6_21828071_ChIP-Seq_BEAS2B_Human2.03007770
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.99831950
26RACK7_27058665_Chip-Seq_MCF-7_Human1.93455249
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.92841835
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.90752610
29MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89488649
30MAF_26560356_Chip-Seq_TH1_Human1.84969196
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79380580
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.79175636
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.78733304
34* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.73740671
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.72867566
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.71840302
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67410658
38MAF_26560356_Chip-Seq_TH2_Human1.66275189
39* P68_20966046_ChIP-Seq_HELA_Human1.63785900
40UTX_26944678_Chip-Seq_JUKART_Human1.63404846
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.59927783
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.59045661
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.54126857
44* SMC4_20622854_ChIP-Seq_HELA_Human1.49865254
45NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43877164
46BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43831885
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41735937
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40613276
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39395875
50LXR_22292898_ChIP-Seq_THP-1_Human1.38480109
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38241062
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38062905
53GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37961955
54ELF1_20517297_ChIP-Seq_JURKAT_Human1.37458325
55CREB1_26743006_Chip-Seq_LNCaP_Human1.36655966
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.34863456
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.34374952
58* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33033765
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32885372
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32030159
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31878335
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31664605
63BCOR_27268052_Chip-Seq_Bcells_Human1.28829896
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27705268
65BCL6_27268052_Chip-Seq_Bcells_Human1.26176750
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26152256
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.25928447
68CTCF_27219007_Chip-Seq_Bcells_Human1.25721780
69KDM2B_26808549_Chip-Seq_K562_Human1.25434327
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24044609
71* NCOR1_26117541_ChIP-Seq_K562_Human1.24043916
72GATA1_19941826_ChIP-Seq_K562_Human1.22860212
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21772997
74REST_21632747_ChIP-Seq_MESCs_Mouse1.21329985
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19976238
76AR_21572438_ChIP-Seq_LNCaP_Human1.19430268
77CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17802157
78PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16940068
79ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16416374
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16414087
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16363516
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13626772
83IRF8_27001747_Chip-Seq_BMDM_Mouse1.12886966
84P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12677173
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.12631035
86* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12111884
87SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11941852
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.11123963
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09509668
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09224657
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09219493
92SCL_19346495_ChIP-Seq_HPC-7_Human1.09203426
93RARB_27405468_Chip-Seq_BRAIN_Mouse1.08432338
94* SPI1_23127762_ChIP-Seq_K562_Human1.07673294
95MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07584437
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.06818929
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06788215
98RUNX_20019798_ChIP-Seq_JUKART_Human1.06684462
99CLOCK_20551151_ChIP-Seq_293T_Human1.06241890
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06077006
101CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05615719
102RXR_22158963_ChIP-Seq_LIVER_Mouse1.05357882
103STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05178479
104PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04169917
105SA1_27219007_Chip-Seq_ERYTHROID_Human1.03975426
106ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03712265
107GATA2_21666600_ChIP-Seq_HMVEC_Human1.03311752
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02015167
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00961641
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00563381
111PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00416510
112* TP63_22573176_ChIP-Seq_HFKS_Human1.00300656
113CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99805220
114KDM2B_26808549_Chip-Seq_JURKAT_Human0.98672608
115SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98661548
116TP53_22127205_ChIP-Seq_IMR90_Human0.97597968
117CTCF_26484167_Chip-Seq_Bcells_Mouse0.97133448
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.97113021
119TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96947476
120KDM2B_26808549_Chip-Seq_DND41_Human0.95710092
121CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95261503
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92331123
123WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91783940
124IGF1R_20145208_ChIP-Seq_DFB_Human0.90746341
125RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90555082
126RING1B_27294783_Chip-Seq_NPCs_Mouse0.89828630
127THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89179478
128TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86581757
129VDR_24763502_ChIP-Seq_THP-1_Human0.85977197
130PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85119656
131SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84668085
132CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83940776
133CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83696802
134ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83578551
135MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82545360
136GATA1_19941827_ChIP-Seq_MEL_Mouse0.82276168
137VDR_21846776_ChIP-Seq_THP-1_Human0.82271309
138AHR_22903824_ChIP-Seq_MCF-7_Human0.82175951
139FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.81753513
140* REST_18959480_ChIP-ChIP_MESCs_Mouse0.81093792
141KDM2B_26808549_Chip-Seq_REH_Human0.80813131
142SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80804519
143NFE2_27457419_Chip-Seq_LIVER_Mouse0.80707316
144BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80655300
145CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.80461491
146VDR_24787735_ChIP-Seq_THP-1_Human0.79915592
147ZFP57_27257070_Chip-Seq_ESCs_Mouse0.79861563
148NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78484257
149PCGF2_27294783_Chip-Seq_NPCs_Mouse0.77299955
150MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.76759399
151LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.76612523
152ARNT_22903824_ChIP-Seq_MCF-7_Human0.76437475
153IRF8_22096565_ChIP-ChIP_GC-B_Human0.75658348
154IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.74871299
155PCGF2_27294783_Chip-Seq_ESCs_Mouse0.74704334
156NANOG_18555785_Chip-Seq_ESCs_Mouse0.73499748
157SA1_27219007_Chip-Seq_Bcells_Human0.73210939
158E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.72803509
159P53_22387025_ChIP-Seq_ESCs_Mouse0.72767984
160RUNX1_27457419_Chip-Seq_LIVER_Mouse0.72725817
161EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.72513017
162SMAD4_21741376_ChIP-Seq_HESCs_Human0.72301506
163BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72278414
164TCF7_22412390_ChIP-Seq_EML_Mouse0.72250885
165TP53_20018659_ChIP-ChIP_R1E_Mouse0.71903617

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.47387021
2MP0005409_darkened_coat_color4.39798364
3MP0004381_abnormal_hair_follicle3.89990083
4MP0005174_abnormal_tail_pigmentation3.83927958
5MP0001188_hyperpigmentation3.37402248
6MP0009379_abnormal_foot_pigmentation3.29877682
7MP0000015_abnormal_ear_pigmentation3.26768325
8MP0003303_peritoneal_inflammation3.01403831
9MP0003705_abnormal_hypodermis_morpholog2.90859158
10MP0000569_abnormal_digit_pigmentation2.56098895
11MP0003724_increased_susceptibility_to2.52869581
12MP0005670_abnormal_white_adipose2.51987265
13MP0009278_abnormal_bone_marrow2.46363110
14MP0009840_abnormal_foam_cell2.11283535
15MP0003880_abnormal_central_pattern2.00083178
16MP0006292_abnormal_olfactory_placode1.94007540
17MP0003279_aneurysm1.92781070
18MP0000685_abnormal_immune_system1.91503515
19MP0005076_abnormal_cell_differentiation1.87867325
20MP0004947_skin_inflammation1.86256334
21MP0004742_abnormal_vestibular_system1.85653244
22MP0001986_abnormal_taste_sensitivity1.85373789
23MP0001968_abnormal_touch/_nociception1.84199935
24MP0001849_ear_inflammation1.84143333
25MP0003191_abnormal_cellular_cholesterol1.82695299
26MP0005451_abnormal_body_composition1.77434756
27MP0001835_abnormal_antigen_presentation1.76050548
28MP0001533_abnormal_skeleton_physiology1.70451179
29MP0001958_emphysema1.69462452
30MP0000751_myopathy1.62454512
31MP0002998_abnormal_bone_remodeling1.59473736
32MP0004510_myositis1.58963150
33MP0004859_abnormal_synaptic_plasticity1.57076384
34MP0003091_abnormal_cell_migration1.56755362
35MP0003329_amyloid_beta_deposits1.51388545
36MP0005058_abnormal_lysosome_morphology1.49849329
37MP0008569_lethality_at_weaning1.43675183
38MP0010155_abnormal_intestine_physiology1.43314929
39MP0002420_abnormal_adaptive_immunity1.43115494
40MP0001819_abnormal_immune_cell1.42333051
41MP0002452_abnormal_antigen_presenting1.42230766
42MP0005423_abnormal_somatic_nervous1.41680355
43MP0006082_CNS_inflammation1.40457643
44MP0001873_stomach_inflammation1.38569496
45MP0000604_amyloidosis1.37403049
46MP0002638_abnormal_pupillary_reflex1.35833443
47MP0009333_abnormal_splenocyte_physiolog1.35293321
48MP0001545_abnormal_hematopoietic_system1.34752070
49MP0005397_hematopoietic_system_phenotyp1.34752070
50MP0003635_abnormal_synaptic_transmissio1.33661918
51MP0002405_respiratory_system_inflammati1.33472271
52MP0005671_abnormal_response_to1.32441646
53MP0001486_abnormal_startle_reflex1.31091390
54MP0000003_abnormal_adipose_tissue1.30822332
55MP0005257_abnormal_intraocular_pressure1.30129485
56MP0009745_abnormal_behavioral_response1.28450641
57MP0001765_abnormal_ion_homeostasis1.26632616
58MP0005360_urolithiasis1.24033143
59MP0004858_abnormal_nervous_system1.23643991
60MP0002396_abnormal_hematopoietic_system1.21912126
61MP0002095_abnormal_skin_pigmentation1.21698760
62MP0002067_abnormal_sensory_capabilities1.21602690
63MP0002272_abnormal_nervous_system1.21565555
64MP0003879_abnormal_hair_cell1.21471636
65MP0005666_abnormal_adipose_tissue1.21300780
66MP0009046_muscle_twitch1.21126073
67MP0009384_cardiac_valve_regurgitation1.19709769
68MP0001348_abnormal_lacrimal_gland1.18743694
69MP0008438_abnormal_cutaneous_collagen1.15696438
70MP0002064_seizures1.15609805
71MP0003453_abnormal_keratinocyte_physiol1.15428034
72MP0005075_abnormal_melanosome_morpholog1.15401529
73MP0000858_altered_metastatic_potential1.14868006
74MP0000716_abnormal_immune_system1.13359518
75MP0002398_abnormal_bone_marrow1.12158364
76MP0005387_immune_system_phenotype1.11865232
77MP0001790_abnormal_immune_system1.11865232
78MP0003183_abnormal_peptide_metabolism1.10531512
79MP0008260_abnormal_autophagy1.09665349
80MP0001970_abnormal_pain_threshold1.08529931
81MP0000767_abnormal_smooth_muscle1.08338840
82MP0009785_altered_susceptibility_to1.07408568
83MP0002909_abnormal_adrenal_gland1.07298819
84MP0005375_adipose_tissue_phenotype1.05008883
85MP0002177_abnormal_outer_ear1.04422681
86MP0005410_abnormal_fertilization1.04215293
87MP0002557_abnormal_social/conspecific_i1.02898398
88MP0000465_gastrointestinal_hemorrhage1.02739369
89MP0004142_abnormal_muscle_tone1.02596566
90MP0004270_analgesia1.02358223
91MP0001851_eye_inflammation1.01778462
92MP0003300_gastrointestinal_ulcer1.01124974
93MP0004145_abnormal_muscle_electrophysio1.00560666
94MP0001853_heart_inflammation1.00078172
95MP0010386_abnormal_urinary_bladder0.99448243
96MP0001845_abnormal_inflammatory_respons0.98978751
97MP0000013_abnormal_adipose_tissue0.98606413
98MP0002277_abnormal_respiratory_mucosa0.97638842
99MP0005390_skeleton_phenotype0.97395415
100MP0003075_altered_response_to0.97295999
101MP0002876_abnormal_thyroid_physiology0.95533129
102MP0003172_abnormal_lysosome_physiology0.95398683
103MP0002138_abnormal_hepatobiliary_system0.94859800
104MP0002166_altered_tumor_susceptibility0.94533261
105MP0003566_abnormal_cell_adhesion0.94197577
106MP0000249_abnormal_blood_vessel0.92989863
107MP0005645_abnormal_hypothalamus_physiol0.91344052
108MP0002429_abnormal_blood_cell0.91297358
109MP0002148_abnormal_hypersensitivity_rea0.91071631
110MP0006138_congestive_heart_failure0.90557385
111MP0000920_abnormal_myelination0.90505873
112MP0003436_decreased_susceptibility_to0.89862558
113MP0004808_abnormal_hematopoietic_stem0.89549394
114MP0000703_abnormal_thymus_morphology0.88798745
115MP0002822_catalepsy0.88533235
116MP0008469_abnormal_protein_level0.87805999
117MP0000733_abnormal_muscle_development0.87381659
118MP0008961_abnormal_basal_metabolism0.87027534
119MP0000579_abnormal_nail_morphology0.86607950
120MP0002722_abnormal_immune_system0.86340775
121MP0005464_abnormal_platelet_physiology0.85473401
122MP0002693_abnormal_pancreas_physiology0.84760727
123MP0002735_abnormal_chemical_nociception0.83452777
124MP0002572_abnormal_emotion/affect_behav0.81894491
125MP0005167_abnormal_blood-brain_barrier0.81875272
126MP0001270_distended_abdomen0.81624402
127MP0000678_abnormal_parathyroid_gland0.81534643
128MP0001664_abnormal_digestion0.81333935
129MP0005025_abnormal_response_to0.81301923
130MP0002249_abnormal_larynx_morphology0.81045793
131MP0003868_abnormal_feces_composition0.80680798
132MP0008995_early_reproductive_senescence0.80632418
133MP0005000_abnormal_immune_tolerance0.80305436
134MP0003787_abnormal_imprinting0.80150722
135MP0001944_abnormal_pancreas_morphology0.80042657
136MP0005166_decreased_susceptibility_to0.79757852
137MP0000689_abnormal_spleen_morphology0.79409040
138MP0004885_abnormal_endolymph0.78865144
139MP0003045_fibrosis0.78560938
140MP0000371_diluted_coat_color0.78386143
141MP0009115_abnormal_fat_cell0.78191157
142MP0004130_abnormal_muscle_cell0.77886762
143MP0002933_joint_inflammation0.77769357
144MP0005023_abnormal_wound_healing0.77347811
145MP0002736_abnormal_nociception_after0.77195550
146MP0003633_abnormal_nervous_system0.76426557
147MP0004185_abnormal_adipocyte_glucose0.76015303
148MP0005535_abnormal_body_temperature0.74886931
149MP0003828_pulmonary_edema0.74842837
150MP0003690_abnormal_glial_cell0.74582613
151MP0003795_abnormal_bone_structure0.74571558
152MP0002419_abnormal_innate_immunity0.74461379
153MP0000747_muscle_weakness0.73814382
154MP0003959_abnormal_lean_body0.73465705
155MP0005595_abnormal_vascular_smooth0.72141051
156MP0001485_abnormal_pinna_reflex0.72088521
157MP0001800_abnormal_humoral_immune0.71522921
158MP0003866_abnormal_defecation0.69827707
159MP0005165_increased_susceptibility_to0.69527781
160MP0001963_abnormal_hearing_physiology0.68648011
161MP0002723_abnormal_immune_serum0.68222017
162MP0002733_abnormal_thermal_nociception0.68040682
163MP0003763_abnormal_thymus_physiology0.67906918
164MP0005379_endocrine/exocrine_gland_phen0.67547319
165MP0001663_abnormal_digestive_system0.65973270
166MP0002971_abnormal_brown_adipose0.64752013

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.22684602
2Testicular atrophy (HP:0000029)4.06438168
3Ocular albinism (HP:0001107)3.89248813
4Cerebral aneurysm (HP:0004944)3.36953651
5Decreased circulating renin level (HP:0003351)3.36477542
6Iris hypopigmentation (HP:0007730)3.36184694
7Broad face (HP:0000283)3.18657799
8Abnormality of secondary sexual hair (HP:0009888)3.10658690
9Abnormality of the axillary hair (HP:0100134)3.10658690
10Joint hemorrhage (HP:0005261)3.08666862
11Glomerulonephritis (HP:0000099)3.07243462
12Thin bony cortex (HP:0002753)3.06470133
13J-shaped sella turcica (HP:0002680)2.98712775
14Absent/shortened dynein arms (HP:0200106)2.94398907
15Dynein arm defect of respiratory motile cilia (HP:0012255)2.94398907
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.94020874
17Cortical visual impairment (HP:0100704)2.89058339
18Thyroid-stimulating hormone excess (HP:0002925)2.88008241
19Cervical subluxation (HP:0003308)2.76911554
20Urinary glycosaminoglycan excretion (HP:0003541)2.76677685
21Mucopolysacchariduria (HP:0008155)2.76677685
22Abnormality of polysaccharide metabolism (HP:0011012)2.69895929
23Abnormality of glycosaminoglycan metabolism (HP:0004371)2.69895929
24Abnormality of mucopolysaccharide metabolism (HP:0011020)2.69895929
25Focal motor seizures (HP:0011153)2.58278757
26Menorrhagia (HP:0000132)2.58073722
27Protrusio acetabuli (HP:0003179)2.57858111
28Systemic lupus erythematosus (HP:0002725)2.57759137
29Chronic mucocutaneous candidiasis (HP:0002728)2.56617229
30Recurrent cutaneous fungal infections (HP:0011370)2.56617229
31Abnormality of calcium-phosphate metabolism (HP:0100530)2.56139214
32Stomatitis (HP:0010280)2.54480643
33Abnormality of the nasal mucosa (HP:0000433)2.50044194
34Metabolic alkalosis (HP:0200114)2.49814639
35Increased IgE level (HP:0003212)2.48972754
36Abnormality of magnesium homeostasis (HP:0004921)2.48251620
37Asymmetric septal hypertrophy (HP:0001670)2.47724189
38Interstitial pulmonary disease (HP:0006530)2.45502935
39Optic nerve hypoplasia (HP:0000609)2.45267408
40Abnormality of the fingertips (HP:0001211)2.44147218
41Split foot (HP:0001839)2.43799682
42Stridor (HP:0010307)2.43289904
43Septo-optic dysplasia (HP:0100842)2.42232763
44Hemorrhage of the eye (HP:0011885)2.41569876
45Abnormality of renin-angiotensin system (HP:0000847)2.40541603
46Attenuation of retinal blood vessels (HP:0007843)2.40422438
47Onion bulb formation (HP:0003383)2.40080053
48Sleep apnea (HP:0010535)2.39794406
49Abnormality of macrophages (HP:0004311)2.38437955
50Thoracic kyphosis (HP:0002942)2.36587798
51Joint stiffness (HP:0001387)2.36065493
52Recurrent abscess formation (HP:0002722)2.34989669
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.34426504
54Obstructive lung disease (HP:0006536)2.33771830
55Chronic obstructive pulmonary disease (HP:0006510)2.33771830
56Agammaglobulinemia (HP:0004432)2.32857169
57Recurrent bacterial skin infections (HP:0005406)2.31959813
58Prolonged partial thromboplastin time (HP:0003645)2.31694941
59Myositis (HP:0100614)2.30836648
60Increased connective tissue (HP:0009025)2.29525653
61Hyperacusis (HP:0010780)2.29081012
62Biconcave vertebral bodies (HP:0004586)2.27516461
63Increased cerebral lipofuscin (HP:0011813)2.27385877
64Nasal polyposis (HP:0100582)2.25079121
65Abnormal delayed hypersensitivity skin test (HP:0002963)2.24287767
66Ulnar claw (HP:0001178)2.23829429
67Reticulocytopenia (HP:0001896)2.23550307
68Emphysema (HP:0002097)2.22136396
69Abnormal sex determination (HP:0012244)2.21828394
70Sex reversal (HP:0012245)2.21828394
71Cellulitis (HP:0100658)2.21546250
72Nonprogressive disorder (HP:0003680)2.20647940
73Hemiplegia (HP:0002301)2.20266656
74Abnormality of glycolipid metabolism (HP:0010969)2.18172103
75Abnormality of liposaccharide metabolism (HP:0010968)2.18172103
76Abnormality of glycosphingolipid metabolism (HP:0004343)2.18172103
77Nuclear cataract (HP:0100018)2.16967905
78Neurofibrillary tangles (HP:0002185)2.15813566
79Recurrent gram-negative bacterial infections (HP:0005420)2.15273815
80Aneurysm (HP:0002617)2.13826560
81Inflammation of the large intestine (HP:0002037)2.11330541
82Exercise-induced myalgia (HP:0003738)2.10782127
83Abnormality of complement system (HP:0005339)2.09787474
84Abnormal respiratory motile cilium physiology (HP:0012261)2.08991252
85Vacuolated lymphocytes (HP:0001922)2.06998363
86Neuronal loss in central nervous system (HP:0002529)2.04933823
87Increased variability in muscle fiber diameter (HP:0003557)2.03976794
88Scanning speech (HP:0002168)2.01745052
89Meningitis (HP:0001287)2.01443172
90Mitral regurgitation (HP:0001653)2.00917315
91Reduced antithrombin III activity (HP:0001976)2.00466570
92Prolonged bleeding time (HP:0003010)1.99966507
93Mediastinal lymphadenopathy (HP:0100721)1.99096841
94Malnutrition (HP:0004395)1.98847813
95Lymphangioma (HP:0100764)1.98435431
96Abnormal ciliary motility (HP:0012262)1.97189130
97Duplicated collecting system (HP:0000081)1.97070533
98Deformed sella turcica (HP:0002681)1.96917162
99Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95714150
100Absent speech (HP:0001344)1.95010749
101Annular pancreas (HP:0001734)1.94856069
102Polygenic inheritance (HP:0010982)1.94446763
103Aplasia cutis congenita (HP:0001057)1.94211722
104Distal lower limb muscle weakness (HP:0009053)1.94041829
105Febrile seizures (HP:0002373)1.93950798
106Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.93703215
107Easy fatigability (HP:0003388)1.93236693
108Eczematoid dermatitis (HP:0000976)1.93169194
109Gastrointestinal infarctions (HP:0005244)1.92383159
110Gastrointestinal inflammation (HP:0004386)1.92183872
111Pustule (HP:0200039)1.92130771
112Hyperkalemia (HP:0002153)1.92092306
113Amyloidosis (HP:0011034)1.91917629
114Hypomagnesemia (HP:0002917)1.91868436
115Complement deficiency (HP:0004431)1.91586696
116Chronic otitis media (HP:0000389)1.90926960
117Loss of speech (HP:0002371)1.90738618
118Abnormality of the renal collecting system (HP:0004742)1.90185410
119Segmental peripheral demyelination/remyelination (HP:0003481)1.90131713
120Abnormality of the thoracic spine (HP:0100711)1.89152283
121Supranuclear gaze palsy (HP:0000605)1.88123632
122Distal upper limb amyotrophy (HP:0007149)1.87974504
123Upper limb amyotrophy (HP:0009129)1.87974504
124Hypertriglyceridemia (HP:0002155)1.87773226
125Vertebral compression fractures (HP:0002953)1.87627858
126Increased neuronal autofluorescent lipopigment (HP:0002074)1.87592843
127Bradycardia (HP:0001662)1.87485821
128Agitation (HP:0000713)1.87211539
129Centrally nucleated skeletal muscle fibers (HP:0003687)1.85802846
130Metaphyseal cupping (HP:0003021)1.85446807
131Nephritis (HP:0000123)1.84309650
132Colitis (HP:0002583)1.84210462
133Orchitis (HP:0100796)1.82133583
134Papilledema (HP:0001085)1.81906912
135Elevated erythrocyte sedimentation rate (HP:0003565)1.81887982
136Disproportionate tall stature (HP:0001519)1.81753546
137Type I transferrin isoform profile (HP:0003642)1.81410664
138Flat acetabular roof (HP:0003180)1.79962691
139Tubulointerstitial nephritis (HP:0001970)1.79186641
140Spinal canal stenosis (HP:0003416)1.79137882
141Gastrointestinal stroma tumor (HP:0100723)1.79105637
142Stage 5 chronic kidney disease (HP:0003774)1.77762683
143Aortic regurgitation (HP:0001659)1.77156456
144Upper limb muscle weakness (HP:0003484)1.75883194
145Distal lower limb amyotrophy (HP:0008944)1.75448295
146Hyperactive renin-angiotensin system (HP:0000841)1.74929444
147Flat occiput (HP:0005469)1.74825906
148Craniofacial hyperostosis (HP:0004493)1.73633406
149Cerebral inclusion bodies (HP:0100314)1.73152739
150Slow saccadic eye movements (HP:0000514)1.72936550
151Restrictive lung disease (HP:0002091)1.72924219
152Dilatation of the ascending aorta (HP:0005111)1.71511425
153Increased serum ferritin (HP:0003281)1.71444081
154Abnormality of skeletal muscle fiber size (HP:0012084)1.71282488
155Dysostosis multiplex (HP:0000943)1.71209942
156Decreased central vision (HP:0007663)1.71032038
157Spontaneous hematomas (HP:0007420)1.70945952
158Hemoptysis (HP:0002105)1.70892831
159Difficulty climbing stairs (HP:0003551)1.70793682
160Purpura (HP:0000979)1.70470851
161Gaze-evoked nystagmus (HP:0000640)1.70236756
162Ulnar bowing (HP:0003031)1.69595878
163Large eyes (HP:0001090)1.68852437
164Concave nail (HP:0001598)1.66548920
165Epistaxis (HP:0000421)1.65202798
166Cerebral palsy (HP:0100021)1.64672758
167Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.64105452
168Generalized hypopigmentation of hair (HP:0011358)1.63428872
169Gingivitis (HP:0000230)1.62428868
170Dry hair (HP:0011359)1.62184283
171Muscle hypertrophy of the lower extremities (HP:0008968)1.62142431
172Esotropia (HP:0000565)1.61367478
173Abnormality of DNA repair (HP:0003254)1.61296266
174Recurrent fungal infections (HP:0002841)1.59090012
175Hyperparathyroidism (HP:0000843)1.58940329
176Recurrent skin infections (HP:0001581)1.57893569
177Abnormality of chloride homeostasis (HP:0011422)1.55136334
178Unilateral renal agenesis (HP:0000122)1.54763672

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.96619562
2TRIB34.50860628
3PRPF4B3.27577224
4TLK13.19172676
5FES2.99014089
6BLK2.95205410
7ERN12.82307337
8TNIK2.59535812
9MKNK22.45371297
10PHKG12.42688359
11PHKG22.42688359
12PRKD22.31608442
13MAP2K32.28639995
14INSRR2.26276140
15TAOK32.01825962
16RIPK11.98690006
17FER1.96717507
18EEF2K1.90848534
19ICK1.84758418
20MAPK151.83566580
21SMG11.80225527
22IRAK31.76575807
23PKN11.74916483
24NLK1.67792103
25SIK21.66063431
26STK381.62228743
27PKN21.61837085
28IRAK41.58156281
29MARK21.48400686
30CAMK1G1.42711136
31IRAK11.38422928
32CDK121.35138631
33MAP3K61.32782251
34IRAK21.26599364
35PDGFRA1.25176734
36RIPK41.23150028
37JAK31.18402600
38CAMK11.17109944
39EPHB11.16662706
40CAMKK21.16338440
41TNK21.13954868
42HIPK21.12009399
43CSK1.11119375
44IKBKE1.09487467
45MAP2K61.09459145
46CLK11.09445964
47NTRK31.07221390
48MAPK71.05685740
49MAP3K71.05411770
50PTK61.05290303
51UHMK11.04505311
52DAPK21.03914849
53PDPK11.02310506
54MAP3K111.01915582
55HCK1.01538597
56STK111.00995548
57DAPK30.99265132
58GRK10.97738060
59PRKAA20.97259460
60MAP3K30.95399990
61RPS6KL10.92892357
62RPS6KC10.92892357
63GRK60.92804633
64MAP4K10.92616663
65DDR20.92603719
66CDK190.92473189
67FGFR30.92349370
68TYRO30.90244309
69SIK30.88454872
70PRKD10.87663667
71MTOR0.87376948
72MAP3K100.86947137
73KIT0.86168851
74LMTK20.85167359
75MAP3K130.84604700
76PDK10.83838300
77CAMK1D0.82413559
78MAPK110.81278397
79TXK0.78129610
80JAK10.78012049
81WNK10.77419875
82RPS6KA60.75795406
83RET0.75294649
84SIK10.75222151
85ITK0.74366205
86MAP3K10.74032957
87MUSK0.73960412
88BMX0.71720498
89CSF1R0.71196521
90MKNK10.71058458
91KSR20.70080679
92TAOK10.70080572
93CAMKK10.68834736
94FGFR40.68547082
95CAMK2B0.67900135
96PRKCH0.67010781
97WNK40.65290927
98MAP2K20.64506395
99TYK20.64152247
100LCK0.64055678
101PDGFRB0.63103959
102MAP3K140.62647789
103YES10.62383426
104TGFBR20.62009856
105BTK0.61101594
106PRKD30.60467119
107IKBKB0.59842923
108TEC0.59467928
109SYK0.59153013
110STK390.58731938
111TAOK20.58681736
112PAK20.57148868
113DYRK1B0.56694160
114GRK70.55893064
115CAMK40.54777276
116ADRBK20.53874943
117MAPK120.51349334
118FGR0.50343081
119TTN0.49007187
120EPHA40.48880188
121MAPK40.48821011
122CHUK0.48380927
123ZAP700.48097468
124MAP2K70.47768246
125TBK10.47442901
126LYN0.47221088
127NTRK20.47127349
128FYN0.46471314
129SGK30.45707962
130MARK30.45653419
131PIK3CG0.45568831
132BRD40.44220172
133RPS6KA20.42667424
134CDC42BPA0.41169273
135TRPM70.40643957
136DMPK0.40600808
137PRKG10.40510445
138MAPK30.40401015
139CDK50.40194627
140EIF2AK20.40060132
141CDK90.39279547
142NTRK10.38779335
143DYRK1A0.38116744
144CDK40.37943544
145STK160.37935572
146NME20.37499728
147JAK20.37082283
148MAPK80.36695247
149PINK10.35593286
150EPHA30.35274203
151ERBB20.33754791

Predicted pathways (KEGG)

RankGene SetZ-score
1Morphine addiction_Homo sapiens_hsa050321.94363984
2Maturity onset diabetes of the young_Homo sapiens_hsa049501.88186946
3Notch signaling pathway_Homo sapiens_hsa043301.77741198
4Taste transduction_Homo sapiens_hsa047421.75940062
5Glutamatergic synapse_Homo sapiens_hsa047241.70246862
6Insulin secretion_Homo sapiens_hsa049111.70144797
7Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67791683
8VEGF signaling pathway_Homo sapiens_hsa043701.67226552
9ABC transporters_Homo sapiens_hsa020101.63551370
10Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.59593381
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.58768595
12Leishmaniasis_Homo sapiens_hsa051401.58261120
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.54268346
14Phototransduction_Homo sapiens_hsa047441.50347740
15* Other glycan degradation_Homo sapiens_hsa005111.47109963
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.46768932
17Nicotine addiction_Homo sapiens_hsa050331.46511308
18Staphylococcus aureus infection_Homo sapiens_hsa051501.46435430
19Olfactory transduction_Homo sapiens_hsa047401.41509717
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.40963692
21Chronic myeloid leukemia_Homo sapiens_hsa052201.40036980
22Salivary secretion_Homo sapiens_hsa049701.39868001
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39746541
24Primary immunodeficiency_Homo sapiens_hsa053401.39172724
25Renin secretion_Homo sapiens_hsa049241.39155793
26Sphingolipid metabolism_Homo sapiens_hsa006001.36970194
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.36738144
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.36291921
29Circadian entrainment_Homo sapiens_hsa047131.36123533
30Calcium signaling pathway_Homo sapiens_hsa040201.35376994
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.32131051
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32013709
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30792439
34GABAergic synapse_Homo sapiens_hsa047271.30376449
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28956723
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.26491906
37Type II diabetes mellitus_Homo sapiens_hsa049301.25837419
38Non-small cell lung cancer_Homo sapiens_hsa052231.25655633
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24529377
40Gastric acid secretion_Homo sapiens_hsa049711.24353432
41Toxoplasmosis_Homo sapiens_hsa051451.22931535
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.22504088
43TNF signaling pathway_Homo sapiens_hsa046681.21988213
44Cholinergic synapse_Homo sapiens_hsa047251.18468164
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18385757
46mTOR signaling pathway_Homo sapiens_hsa041501.17889239
47Pancreatic secretion_Homo sapiens_hsa049721.16256635
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.15049851
49Long-term depression_Homo sapiens_hsa047301.14905596
50Osteoclast differentiation_Homo sapiens_hsa043801.14343884
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14109774
52B cell receptor signaling pathway_Homo sapiens_hsa046621.13172944
53Tuberculosis_Homo sapiens_hsa051521.10271113
54Serotonergic synapse_Homo sapiens_hsa047261.06168480
55cAMP signaling pathway_Homo sapiens_hsa040241.05777829
56Influenza A_Homo sapiens_hsa051641.04953239
57Prolactin signaling pathway_Homo sapiens_hsa049171.04685817
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.03043225
59Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02549728
60Melanogenesis_Homo sapiens_hsa049161.00725640
61Pertussis_Homo sapiens_hsa051331.00122509
62Hepatitis C_Homo sapiens_hsa051600.99621968
63Lysine degradation_Homo sapiens_hsa003100.99435197
64Allograft rejection_Homo sapiens_hsa053300.98249671
65Pancreatic cancer_Homo sapiens_hsa052120.97778242
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.97337889
67Axon guidance_Homo sapiens_hsa043600.96260394
68Prion diseases_Homo sapiens_hsa050200.94841374
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.94059692
70Amphetamine addiction_Homo sapiens_hsa050310.92854846
71Insulin signaling pathway_Homo sapiens_hsa049100.91663167
72Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91578586
73Graft-versus-host disease_Homo sapiens_hsa053320.90921780
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.89827554
75Hepatitis B_Homo sapiens_hsa051610.89422372
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88462128
77Cocaine addiction_Homo sapiens_hsa050300.87801976
78GnRH signaling pathway_Homo sapiens_hsa049120.87645699
79Amoebiasis_Homo sapiens_hsa051460.87158145
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87015384
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.86658989
82Chemokine signaling pathway_Homo sapiens_hsa040620.86086786
83Fructose and mannose metabolism_Homo sapiens_hsa000510.85921757
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85906105
85Autoimmune thyroid disease_Homo sapiens_hsa053200.85055751
86Renal cell carcinoma_Homo sapiens_hsa052110.84603879
87Inositol phosphate metabolism_Homo sapiens_hsa005620.83402146
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83069279
89Endometrial cancer_Homo sapiens_hsa052130.82285560
90Glioma_Homo sapiens_hsa052140.82100513
91T cell receptor signaling pathway_Homo sapiens_hsa046600.81897971
92ErbB signaling pathway_Homo sapiens_hsa040120.80651303
93Glucagon signaling pathway_Homo sapiens_hsa049220.78295261
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74861633
95Glycerolipid metabolism_Homo sapiens_hsa005610.74840957
96Focal adhesion_Homo sapiens_hsa045100.74371865
97Protein digestion and absorption_Homo sapiens_hsa049740.74340934
98Oxytocin signaling pathway_Homo sapiens_hsa049210.73875873
99Hematopoietic cell lineage_Homo sapiens_hsa046400.71732039
100Viral myocarditis_Homo sapiens_hsa054160.71671522
101Acute myeloid leukemia_Homo sapiens_hsa052210.71667696
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70714434
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68996353
104Dopaminergic synapse_Homo sapiens_hsa047280.68925214
105Bladder cancer_Homo sapiens_hsa052190.68669828
106Herpes simplex infection_Homo sapiens_hsa051680.68666033
107Choline metabolism in cancer_Homo sapiens_hsa052310.68603712
108AMPK signaling pathway_Homo sapiens_hsa041520.67936211
109Long-term potentiation_Homo sapiens_hsa047200.67433913
110Dilated cardiomyopathy_Homo sapiens_hsa054140.67247473
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.67153893
112Lysosome_Homo sapiens_hsa041420.65113792
113Apoptosis_Homo sapiens_hsa042100.65016369
114Arachidonic acid metabolism_Homo sapiens_hsa005900.64521238
115Endocytosis_Homo sapiens_hsa041440.64038404
116Ether lipid metabolism_Homo sapiens_hsa005650.63671902
117Measles_Homo sapiens_hsa051620.63621868
118HIF-1 signaling pathway_Homo sapiens_hsa040660.63498878
119FoxO signaling pathway_Homo sapiens_hsa040680.62907608
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61292622
121Dorso-ventral axis formation_Homo sapiens_hsa043200.61129792
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59422241
123Complement and coagulation cascades_Homo sapiens_hsa046100.58928370
124Insulin resistance_Homo sapiens_hsa049310.57098461
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56739197
126HTLV-I infection_Homo sapiens_hsa051660.56718855
127Estrogen signaling pathway_Homo sapiens_hsa049150.56576244
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.55973509
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55648202
130Colorectal cancer_Homo sapiens_hsa052100.55612006
131Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55363740
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.55080065
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.54238376
134Rap1 signaling pathway_Homo sapiens_hsa040150.53982595
135Wnt signaling pathway_Homo sapiens_hsa043100.53910305
136Platelet activation_Homo sapiens_hsa046110.53888270
137Thyroid hormone synthesis_Homo sapiens_hsa049180.53306287
138Ras signaling pathway_Homo sapiens_hsa040140.52795624
139MAPK signaling pathway_Homo sapiens_hsa040100.52057528
140PPAR signaling pathway_Homo sapiens_hsa033200.51905970
141Small cell lung cancer_Homo sapiens_hsa052220.51351910
142Basal cell carcinoma_Homo sapiens_hsa052170.51120018
143Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51005859
144Salmonella infection_Homo sapiens_hsa051320.50740699
145Leukocyte transendothelial migration_Homo sapiens_hsa046700.50714211
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50408368
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48319601
148RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47545624
149Malaria_Homo sapiens_hsa051440.46679740
150Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45344814
151Jak-STAT signaling pathway_Homo sapiens_hsa046300.44935322
152Nitrogen metabolism_Homo sapiens_hsa009100.44739371
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.44304650

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