MANBA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with beta-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of other organism (GO:0098543)4.69743165
2negative regulation of interleukin-12 production (GO:0032695)4.63481346
3detection of external biotic stimulus (GO:0098581)4.31830008
4detection of bacterium (GO:0016045)4.19574285
5positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.12711322
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.92107977
7negative regulation of cell killing (GO:0031342)3.92107977
8folic acid-containing compound biosynthetic process (GO:0009396)3.90791566
9detection of biotic stimulus (GO:0009595)3.84444459
10regulation of mast cell degranulation (GO:0043304)3.81212475
11microglial cell activation (GO:0001774)3.70684845
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.70243865
13IMP biosynthetic process (GO:0006188)3.61674991
14regulation of gamma-delta T cell activation (GO:0046643)3.59252877
15positive regulation of mast cell activation (GO:0033005)3.56349097
16regulation of mast cell activation involved in immune response (GO:0033006)3.56100195
17regulation of leukocyte degranulation (GO:0043300)3.55719940
18regulation of myeloid leukocyte mediated immunity (GO:0002886)3.55547738
19macrophage activation (GO:0042116)3.48518211
20response to muramyl dipeptide (GO:0032495)3.43680846
21regulation of mast cell activation (GO:0033003)3.37958861
22myeloid cell activation involved in immune response (GO:0002275)3.36691376
23IMP metabolic process (GO:0046040)3.34349169
24T-helper 1 type immune response (GO:0042088)3.32416913
25neutrophil mediated immunity (GO:0002446)3.32376181
26positive regulation of mast cell activation involved in immune response (GO:0033008)3.28230895
27positive regulation of mast cell degranulation (GO:0043306)3.28230895
28nuclear pore complex assembly (GO:0051292)3.27622284
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.26949305
30positive regulation by organism of defense response of other organism involved in symbiotic interact3.26949305
31modulation by symbiont of host immune response (GO:0052553)3.26949305
32positive regulation by symbiont of host defense response (GO:0052509)3.26949305
33modulation by symbiont of host defense response (GO:0052031)3.26949305
34modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.26949305
35nuclear pore organization (GO:0006999)3.26566351
36regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.23826027
37lipopolysaccharide-mediated signaling pathway (GO:0031663)3.22304374
38regulation of antigen processing and presentation (GO:0002577)3.13487788
39determination of adult lifespan (GO:0008340)3.13430316
40positive regulation of leukocyte degranulation (GO:0043302)3.13421573
41positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.13062818
42oligosaccharide catabolic process (GO:0009313)3.12838879
43response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.11700144
44response to host (GO:0075136)3.11700144
45response to host defenses (GO:0052200)3.11700144
46defense response to protozoan (GO:0042832)3.10433548
47positive regulation of interferon-alpha production (GO:0032727)3.10163463
48B cell receptor signaling pathway (GO:0050853)3.08660918
49regulation of interleukin-8 biosynthetic process (GO:0045414)3.06153620
50negative regulation of interleukin-17 production (GO:0032700)3.05810130
51regulation of macrophage cytokine production (GO:0010935)3.03514613
52response to protozoan (GO:0001562)3.02865805
53B cell mediated immunity (GO:0019724)3.02641101
54interferon-gamma-mediated signaling pathway (GO:0060333)3.02170943
55negative regulation of erythrocyte differentiation (GO:0045647)3.00452100
56positive regulation of toll-like receptor signaling pathway (GO:0034123)2.96459705
57positive regulation of cellular amide metabolic process (GO:0034250)2.96246161
58germinal center formation (GO:0002467)2.94088659
59antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.94062231
60antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.94062231
61regulation of dendritic cell antigen processing and presentation (GO:0002604)2.93633532
62immunoglobulin mediated immune response (GO:0016064)2.92987552
63positive regulation of macrophage cytokine production (GO:0060907)2.90663490
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.90376865
65tetrahydrofolate metabolic process (GO:0046653)2.89925258
66regulation of interferon-alpha production (GO:0032647)2.89335653
67cellular response to thyroid hormone stimulus (GO:0097067)2.86934679
68negative regulation of cytokine production involved in immune response (GO:0002719)2.86189361
69pore complex assembly (GO:0046931)2.85509293
70regulation of regulated secretory pathway (GO:1903305)2.82929608
71regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.82826938
72regulation of helicase activity (GO:0051095)2.82281490
73negative regulation of interleukin-6 production (GO:0032715)2.82084972
74myeloid leukocyte mediated immunity (GO:0002444)2.80180819
75glycosphingolipid catabolic process (GO:0046479)2.79518106
76regulation of interferon-beta biosynthetic process (GO:0045357)2.79298219
77leukocyte aggregation (GO:0070486)2.77483561
78neutrophil activation involved in immune response (GO:0002283)2.75585131
79positive regulation of SMAD protein import into nucleus (GO:0060391)2.75540087
80positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.73041280
81positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.72552921
82regulation of posttranscriptional gene silencing (GO:0060147)2.71663323
83regulation of gene silencing by miRNA (GO:0060964)2.71663323
84regulation of gene silencing by RNA (GO:0060966)2.71663323
85pinocytosis (GO:0006907)2.69717911
86negative regulation of T cell mediated immunity (GO:0002710)2.69284714
87regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.69001164
88production of molecular mediator involved in inflammatory response (GO:0002532)2.68769080
89negative regulation of leukocyte mediated immunity (GO:0002704)2.68629750
90antigen processing and presentation of endogenous antigen (GO:0019883)2.66290303
91myeloid leukocyte activation (GO:0002274)2.66030598
92negative regulation of lymphocyte mediated immunity (GO:0002707)2.65893345
93DNA replication initiation (GO:0006270)2.63372229
94regulation of tolerance induction (GO:0002643)2.62904047
95negative regulation of innate immune response (GO:0045824)2.62601716
96positive regulation of interferon-beta production (GO:0032728)2.59302673
97positive regulation of gamma-delta T cell activation (GO:0046645)2.57907000
98pteridine-containing compound biosynthetic process (GO:0042559)2.56657849
99nucleobase biosynthetic process (GO:0046112)2.56117115
100response to interferon-beta (GO:0035456)2.52638306
101positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.51145295
102response to peptidoglycan (GO:0032494)2.45203594
103purine nucleobase biosynthetic process (GO:0009113)2.42936786
104somatic hypermutation of immunoglobulin genes (GO:0016446)2.41713110
105somatic diversification of immune receptors via somatic mutation (GO:0002566)2.41713110
106DNA strand elongation involved in DNA replication (GO:0006271)2.41450627
107embryonic process involved in female pregnancy (GO:0060136)2.40483761
108positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.38424247
109positive regulation of protein import into nucleus, translocation (GO:0033160)2.38326209
110DNA geometric change (GO:0032392)2.38304867
111folic acid-containing compound metabolic process (GO:0006760)2.37202238
112macrophage activation involved in immune response (GO:0002281)2.36519014
113positive regulation of B cell differentiation (GO:0045579)2.35986614
114DNA duplex unwinding (GO:0032508)2.35743328
115detection of molecule of bacterial origin (GO:0032490)2.34393058
116DNA strand elongation (GO:0022616)2.32682220
117mitotic nuclear envelope disassembly (GO:0007077)2.31822920
118peptide catabolic process (GO:0043171)2.29500781
119regulation of SMAD protein import into nucleus (GO:0060390)2.29013554
120regulation of gene silencing (GO:0060968)2.28520848
121valine metabolic process (GO:0006573)2.27832565
122cellular response to interferon-beta (GO:0035458)2.25652900
123DNA unwinding involved in DNA replication (GO:0006268)2.24147374
124regulation of B cell receptor signaling pathway (GO:0050855)2.19922680
125regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.19408746
126response to interferon-alpha (GO:0035455)2.19269971
127telomere maintenance via semi-conservative replication (GO:0032201)2.17868051
128respiratory burst (GO:0045730)2.17209353
129response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.16161899
130response to host immune response (GO:0052572)2.16161899
131Golgi transport vesicle coating (GO:0048200)2.15370981
132COPI coating of Golgi vesicle (GO:0048205)2.15370981
133protein K6-linked ubiquitination (GO:0085020)2.14297383
134formation of translation preinitiation complex (GO:0001731)2.13637627
135folic acid metabolic process (GO:0046655)2.12852998
136negative regulation of B cell proliferation (GO:0030889)2.10362669
137regulation of chromatin silencing (GO:0031935)2.09517772
138regulation of translational fidelity (GO:0006450)2.08609061
139granulocyte activation (GO:0036230)2.07741103
140basic amino acid transport (GO:0015802)2.07557595
141embryonic placenta development (GO:0001892)2.07218319
142membrane disassembly (GO:0030397)2.06110966
143nuclear envelope disassembly (GO:0051081)2.06110966
144pteridine-containing compound metabolic process (GO:0042558)2.04563697
145neutrophil activation (GO:0042119)2.04377672
146toxin transport (GO:1901998)1.99568903
147glycine metabolic process (GO:0006544)1.99295579
148regulation of interferon-beta production (GO:0032648)1.99168740
149cytokine secretion (GO:0050663)1.98989740
150urate metabolic process (GO:0046415)1.98668055
151positive regulation of antigen processing and presentation (GO:0002579)1.98353598
152regulation of histone H3-K9 methylation (GO:0051570)1.97583496
153antigen processing and presentation via MHC class Ib (GO:0002475)1.97329984
154cellular extravasation (GO:0045123)1.97125388
155telomere maintenance via recombination (GO:0000722)1.96423405
156regulation of B cell differentiation (GO:0045577)1.96418505
157regulation of gamma-delta T cell differentiation (GO:0045586)1.96417976
158regulation of protein import into nucleus, translocation (GO:0033158)1.96267518
159mismatch repair (GO:0006298)1.95996539
160L-alpha-amino acid transmembrane transport (GO:1902475)1.95978211
161protein localization to kinetochore (GO:0034501)1.95683824
162natural killer cell mediated cytotoxicity (GO:0042267)1.95329763
163natural killer cell mediated immunity (GO:0002228)1.95329763

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.37589756
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.07931276
3EGR1_19374776_ChIP-ChIP_THP-1_Human2.81879955
4IRF8_21731497_ChIP-ChIP_J774_Mouse2.76495266
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.61633617
6VDR_24763502_ChIP-Seq_THP-1_Human2.38725906
7* SPI1_23127762_ChIP-Seq_K562_Human2.38119344
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.31647916
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.30615022
10RUNX_20019798_ChIP-Seq_JUKART_Human2.25014196
11VDR_24787735_ChIP-Seq_THP-1_Human2.24117782
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.12917337
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.11470060
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.10403172
15* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.02623556
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.01216412
17NANOG_18555785_ChIP-Seq_MESCs_Mouse1.96300622
18* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.87604715
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.86644974
20STAT3_1855785_ChIP-Seq_MESCs_Mouse1.83841259
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.83003273
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.82576188
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.80554248
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.79756871
25IRF8_27001747_Chip-Seq_BMDM_Mouse1.76600725
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.76479167
27* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.75633481
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75490152
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74500904
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73805573
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.73466262
32* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72178490
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69040503
34* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63470419
35NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.62979509
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61712584
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.61139008
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60745858
39KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.59761769
40KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.59761769
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.59761769
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59217412
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.56615299
44* SPI1_23547873_ChIP-Seq_NB4_Human1.55799934
45EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54425998
46MAF_26560356_Chip-Seq_TH1_Human1.54030590
47NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.53717927
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.53623253
49TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51521043
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49420483
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.46708108
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.46253441
53TFEB_21752829_ChIP-Seq_HELA_Human1.44676105
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.44083753
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43921390
56MYC_22102868_ChIP-Seq_BL_Human1.43324722
57GATA3_27048872_Chip-Seq_THYMUS_Human1.43084401
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.40702833
59PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39475883
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39121401
61* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39062732
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38803094
63SCL_19346495_ChIP-Seq_HPC-7_Human1.36253196
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.36097665
65BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36083013
66GATA1_22025678_ChIP-Seq_K562_Human1.34804734
67* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34728191
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34311532
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.33855153
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33726365
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.33343368
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32279120
73PPARA_22158963_ChIP-Seq_LIVER_Mouse1.31781578
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31671429
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31556859
76ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30586337
77GATA3_26560356_Chip-Seq_TH2_Human1.28247486
78AR_21909140_ChIP-Seq_LNCAP_Human1.28187616
79UTX_26944678_Chip-Seq_JUKART_Human1.26584360
80STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26374738
81* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24958814
82KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23692386
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23095584
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22742770
85GATA1_19941826_ChIP-Seq_K562_Human1.22605381
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21297970
87Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20201640
88TCF3_18692474_ChIP-Seq_MESCs_Mouse1.19328629
89RXR_22158963_ChIP-Seq_LIVER_Mouse1.19178470
90TCF7_22412390_ChIP-Seq_EML_Mouse1.18880738
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.18610849
92RUNX1_22412390_ChIP-Seq_EML_Mouse1.18131519
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18116877
94MYB_26560356_Chip-Seq_TH2_Human1.17152815
95EST1_17652178_ChIP-ChIP_JURKAT_Human1.16459262
96CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15648493
97GATA2_19941826_ChIP-Seq_K562_Human1.15146692
98RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14720566
99* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14613589
100GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12173291
101MYB_26560356_Chip-Seq_TH1_Human1.12111249
102GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12046117
103STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11583081
104FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11538432
105STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11532507
106CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10252628
107STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.09999316
108ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07365465
109ELK1_19687146_ChIP-ChIP_HELA_Human1.07336032
110POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07165800
111NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.07146840
112TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06409417
113MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06321227
114CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05881896
115PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05831342
116NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.05088514
117ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04746424
118FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04550275
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03946797
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03641098
121VDR_23849224_ChIP-Seq_CD4+_Human1.03561739
122JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01933956
123VDR_21846776_ChIP-Seq_THP-1_Human1.01538814
124GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01159574
125FOXP3_21729870_ChIP-Seq_TREG_Human1.01143780
126CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00463723
127SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99788621
128* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97458322
129SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.97242036
130PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96454234
131CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95528749
132RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95419473
133PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95033749
134CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94395603
135SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94376455
136SRF_21415370_ChIP-Seq_HL-1_Mouse0.93781365
137GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93087985
138KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93005251
139KAP1_27257070_Chip-Seq_ESCs_Mouse0.92048891
140SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91632257
141LXR_22158963_ChIP-Seq_LIVER_Mouse0.91208059
142PU_27001747_Chip-Seq_BMDM_Mouse0.90765066
143FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88939553
144CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84211255
145SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83216625
146MAF_26560356_Chip-Seq_TH2_Human0.82332107
147NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82308640
148NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82308640
149KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.79584227
150KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.78689973
151RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.77720747
152FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77259787
153GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72287480
154GATA1_19941827_ChIP-Seq_MEL86_Mouse0.71295268
155FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.71221740

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.41734652
2MP0001835_abnormal_antigen_presentation2.56668823
3MP0003806_abnormal_nucleotide_metabolis2.50385351
4MP0005058_abnormal_lysosome_morphology2.49552988
5MP0003191_abnormal_cellular_cholesterol2.39967824
6MP0003693_abnormal_embryo_hatching2.16093753
7MP0003436_decreased_susceptibility_to2.08814007
8MP0010352_gastrointestinal_tract_polyps2.04285101
9MP0003828_pulmonary_edema2.03156880
10MP0003566_abnormal_cell_adhesion1.98471776
11MP0005360_urolithiasis1.95290993
12MP0010307_abnormal_tumor_latency1.94404442
13MP0008057_abnormal_DNA_replication1.90331517
14MP0006082_CNS_inflammation1.90091265
15MP0010094_abnormal_chromosome_stability1.89051899
16MP0000604_amyloidosis1.85268849
17MP0009785_altered_susceptibility_to1.74730676
18MP0002419_abnormal_innate_immunity1.73334480
19MP0002396_abnormal_hematopoietic_system1.71155554
20MP0008260_abnormal_autophagy1.70710349
21MP0002148_abnormal_hypersensitivity_rea1.64277816
22MP0008058_abnormal_DNA_repair1.60849657
23MP0004957_abnormal_blastocyst_morpholog1.59974441
24MP0003111_abnormal_nucleus_morphology1.59537405
25MP0002998_abnormal_bone_remodeling1.58893090
26MP0005025_abnormal_response_to1.58859790
27MP0003075_altered_response_to1.58545092
28MP0003077_abnormal_cell_cycle1.58125342
29MP0003656_abnormal_erythrocyte_physiolo1.55164497
30MP0009840_abnormal_foam_cell1.54215877
31MP0005464_abnormal_platelet_physiology1.51936852
32MP0002452_abnormal_antigen_presenting1.51401779
33MP0002139_abnormal_hepatobiliary_system1.51102090
34MP0001800_abnormal_humoral_immune1.48629011
35MP0003186_abnormal_redox_activity1.47855635
36MP0000371_diluted_coat_color1.47505238
37MP0005000_abnormal_immune_tolerance1.46780066
38MP0000490_abnormal_crypts_of1.45326583
39MP0005451_abnormal_body_composition1.44851416
40MP0003690_abnormal_glial_cell1.42421555
41MP0002254_reproductive_system_inflammat1.41385963
42MP0000685_abnormal_immune_system1.40875577
43MP0003183_abnormal_peptide_metabolism1.37810972
44MP0000569_abnormal_digit_pigmentation1.37224729
45MP0008007_abnormal_cellular_replicative1.35949913
46MP0000858_altered_metastatic_potential1.35474018
47* MP0003172_abnormal_lysosome_physiology1.34911860
48MP0004883_abnormal_blood_vessel1.33615239
49MP0002877_abnormal_melanocyte_morpholog1.33511108
50MP0004264_abnormal_extraembryonic_tissu1.32632933
51MP0002138_abnormal_hepatobiliary_system1.32366413
52MP0001545_abnormal_hematopoietic_system1.31301200
53MP0005397_hematopoietic_system_phenotyp1.31301200
54MP0002723_abnormal_immune_serum1.30896953
55MP0001790_abnormal_immune_system1.30043609
56MP0005387_immune_system_phenotype1.30043609
57MP0003300_gastrointestinal_ulcer1.28941343
58MP0003705_abnormal_hypodermis_morpholog1.28874196
59MP0001819_abnormal_immune_cell1.27412307
60MP0002420_abnormal_adaptive_immunity1.27243342
61MP0005164_abnormal_response_to1.26705263
62MP0003448_altered_tumor_morphology1.26358124
63MP0005085_abnormal_gallbladder_physiolo1.26278255
64MP0005023_abnormal_wound_healing1.25450781
65MP0000689_abnormal_spleen_morphology1.25205532
66MP0009643_abnormal_urine_homeostasis1.25133566
67MP0008004_abnormal_stomach_pH1.24832059
68MP0003252_abnormal_bile_duct1.24027374
69MP0001845_abnormal_inflammatory_respons1.23330373
70MP0002405_respiratory_system_inflammati1.22617069
71MP0005671_abnormal_response_to1.22279364
72MP0010155_abnormal_intestine_physiology1.21679011
73MP0003724_increased_susceptibility_to1.19291760
74MP0005365_abnormal_bile_salt1.16418930
75MP0002398_abnormal_bone_marrow1.15781010
76MP0008469_abnormal_protein_level1.13592395
77MP0002136_abnormal_kidney_physiology1.11395982
78MP0009333_abnormal_splenocyte_physiolog1.10259645
79MP0004019_abnormal_vitamin_homeostasis1.10114086
80MP0003195_calcinosis1.09931167
81* MP0000716_abnormal_immune_system1.08681375
82MP0002722_abnormal_immune_system1.07659575
83* MP0002429_abnormal_blood_cell1.07029190
84MP0004808_abnormal_hematopoietic_stem1.06495221
85MP0002132_abnormal_respiratory_system1.05973072
86MP0001853_heart_inflammation1.05176312
87MP0002019_abnormal_tumor_incidence1.03042179
88MP0001851_eye_inflammation1.02909290
89MP0001915_intracranial_hemorrhage1.01877401
90MP0009763_increased_sensitivity_to1.00094702
91MP0006054_spinal_hemorrhage1.00038849
92MP0009278_abnormal_bone_marrow0.99756029
93MP0005166_decreased_susceptibility_to0.98038926
94MP0001730_embryonic_growth_arrest0.98012731
95MP0001533_abnormal_skeleton_physiology0.96254059
96MP0004782_abnormal_surfactant_physiolog0.95429538
97MP0004510_myositis0.94877976
98MP0000343_altered_response_to0.94741777
99MP0000609_abnormal_liver_physiology0.94046086
100MP0002086_abnormal_extraembryonic_tissu0.93938793
101MP0005076_abnormal_cell_differentiation0.93767845
102MP0005332_abnormal_amino_acid0.93139052
103MP0000350_abnormal_cell_proliferation0.93109694
104MP0000465_gastrointestinal_hemorrhage0.90474834
105MP0005319_abnormal_enzyme/_coenzyme0.89819156
106* MP0000598_abnormal_liver_morphology0.89495084
107MP0003283_abnormal_digestive_organ0.89051169
108MP0008438_abnormal_cutaneous_collagen0.85827946
109MP0005390_skeleton_phenotype0.85643807
110MP0002006_tumorigenesis0.85197705
111MP0003329_amyloid_beta_deposits0.84103898
112MP0003866_abnormal_defecation0.83404333
113MP0009764_decreased_sensitivity_to0.82433081
114MP0002166_altered_tumor_susceptibility0.81679482
115MP0005408_hypopigmentation0.80769831
116MP0003091_abnormal_cell_migration0.80694221
117MP0003763_abnormal_thymus_physiology0.80576312
118MP0003795_abnormal_bone_structure0.80248084
119MP0000249_abnormal_blood_vessel0.79071448
120MP0010234_abnormal_vibrissa_follicle0.78849044
121MP0001764_abnormal_homeostasis0.78656464
122MP0005310_abnormal_salivary_gland0.77633119
123MP0000313_abnormal_cell_death0.77495172
124MP0009765_abnormal_xenobiotic_induced0.76596802
125MP0004947_skin_inflammation0.76592269
126MP0001849_ear_inflammation0.75354380
127MP0002075_abnormal_coat/hair_pigmentati0.71574906
128MP0005167_abnormal_blood-brain_barrier0.71383538
129MP0003453_abnormal_keratinocyte_physiol0.70920442
130MP0005165_increased_susceptibility_to0.69530513
131MP0002933_joint_inflammation0.68403392
132MP0005075_abnormal_melanosome_morpholog0.67144048
133MP0002009_preneoplasia0.64963867
134MP0000703_abnormal_thymus_morphology0.64256459
135MP0003279_aneurysm0.64194732
136MP0001663_abnormal_digestive_system0.63775777
137MP0001958_emphysema0.62378744
138MP0000920_abnormal_myelination0.60240034

Predicted human phenotypes

RankGene SetZ-score
1Agnosia (HP:0010524)3.98921225
2Recurrent abscess formation (HP:0002722)3.84538625
3Vacuolated lymphocytes (HP:0001922)3.56600130
4Loss of speech (HP:0002371)3.37993849
5Systemic lupus erythematosus (HP:0002725)3.34187111
6Eczematoid dermatitis (HP:0000976)3.29320036
7Chronic obstructive pulmonary disease (HP:0006510)3.20142460
8Obstructive lung disease (HP:0006536)3.20142460
9Gastrointestinal infarctions (HP:0005244)3.17240032
10Stomatitis (HP:0010280)3.17221499
11Amyloidosis (HP:0011034)3.16385003
12Recurrent bacterial skin infections (HP:0005406)3.15364964
13Disinhibition (HP:0000734)3.09179276
14Recurrent gram-negative bacterial infections (HP:0005420)3.05114249
15Abnormality of pyrimidine metabolism (HP:0004353)2.90706785
16Meningitis (HP:0001287)2.90138541
17Mucopolysacchariduria (HP:0008155)2.85531272
18Urinary glycosaminoglycan excretion (HP:0003541)2.85531272
19Prolonged bleeding time (HP:0003010)2.82619268
20Vasculitis (HP:0002633)2.73613375
21Abnormality of glycosaminoglycan metabolism (HP:0004371)2.73032350
22Abnormality of mucopolysaccharide metabolism (HP:0011020)2.73032350
23Abnormality of polysaccharide metabolism (HP:0011012)2.73032350
24T lymphocytopenia (HP:0005403)2.70419049
25Abnormality of macrophages (HP:0004311)2.69984108
26Autoimmune thrombocytopenia (HP:0001973)2.69007792
27Dysostosis multiplex (HP:0000943)2.68359233
28Keratoconjunctivitis sicca (HP:0001097)2.67309432
29Peritonitis (HP:0002586)2.66614608
30Pulmonary infiltrates (HP:0002113)2.66499567
31Urticaria (HP:0001025)2.65386320
32Chest pain (HP:0100749)2.62045711
33Metaphyseal cupping (HP:0003021)2.59564597
34Purpura (HP:0000979)2.55412722
35Recurrent cutaneous fungal infections (HP:0011370)2.54994973
36Chronic mucocutaneous candidiasis (HP:0002728)2.54994973
37Cellulitis (HP:0100658)2.54549748
38Abnormality of T cell number (HP:0011839)2.51130788
39Hemoptysis (HP:0002105)2.50428017
40Abnormality of monocarboxylic acid metabolism (HP:0010996)2.44944971
41IgM deficiency (HP:0002850)2.43299121
42Increased cerebral lipofuscin (HP:0011813)2.42854764
43Chromsome breakage (HP:0040012)2.40622398
44Colitis (HP:0002583)2.39713983
45Spastic diplegia (HP:0001264)2.37664667
46Inflammation of the large intestine (HP:0002037)2.37601787
47Joint hemorrhage (HP:0005261)2.37367026
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.36795312
49Increased neuronal autofluorescent lipopigment (HP:0002074)2.36696805
50Keratoconjunctivitis (HP:0001096)2.36531089
51Amaurosis fugax (HP:0100576)2.36175069
52Myositis (HP:0100614)2.36088991
53Leukocytosis (HP:0001974)2.35707014
54Glomerulonephritis (HP:0000099)2.34301210
55Ependymoma (HP:0002888)2.33720307
56Pulmonary embolism (HP:0002204)2.33609150
57Thrombocytosis (HP:0001894)2.30129553
58Encephalitis (HP:0002383)2.30012385
59Esophageal varix (HP:0002040)2.29658030
60Increased serum ferritin (HP:0003281)2.29006954
61Gastrointestinal inflammation (HP:0004386)2.26767463
62Chromosomal breakage induced by crosslinking agents (HP:0003221)2.20074044
63Upper motor neuron abnormality (HP:0002127)2.18879322
64Episodic fever (HP:0001954)2.17656128
65Hepatosplenomegaly (HP:0001433)2.16225660
66Mediastinal lymphadenopathy (HP:0100721)2.15972505
67* Abnormality of the vasculature of the conjunctiva (HP:0008054)2.13711801
68Abnormality of iron homeostasis (HP:0011031)2.12557255
69Spontaneous hematomas (HP:0007420)2.10558294
70Spondylolisthesis (HP:0003302)2.10051448
71Birth length less than 3rd percentile (HP:0003561)2.08547282
72Intrahepatic cholestasis (HP:0001406)2.06096089
73Pathologic fracture (HP:0002756)2.04792703
74Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04450703
75Abnormality of glutamine family amino acid metabolism (HP:0010902)2.02982964
76Acute hepatic failure (HP:0006554)2.02260109
77Abnormality of chromosome stability (HP:0003220)2.02158789
78Viral hepatitis (HP:0006562)2.00946075
79Abnormality of nucleobase metabolism (HP:0010932)2.00775502
80Complement deficiency (HP:0004431)1.99475142
81Periodontitis (HP:0000704)1.99465502
82Abnormality of the peritoneum (HP:0002585)1.98273503
83Polyneuropathy (HP:0001271)1.97820314
84Anorexia (HP:0002039)1.96909385
85Progressive neurologic deterioration (HP:0002344)1.96508254
86Recurrent fungal infections (HP:0002841)1.92968140
87Gangrene (HP:0100758)1.92806012
88Neurofibrillary tangles (HP:0002185)1.91800675
89Gingivitis (HP:0000230)1.91267098
90Abnormality of the lumbar spine (HP:0100712)1.90817951
91Abnormality of complement system (HP:0005339)1.90220201
92Basal ganglia calcification (HP:0002135)1.89280803
93Orchitis (HP:0100796)1.88558172
94Gingival bleeding (HP:0000225)1.88527900
95Abnormality of the pleura (HP:0002103)1.88390501
96Panhypogammaglobulinemia (HP:0003139)1.87861704
97Abnormality of T cells (HP:0002843)1.87215955
98Mutism (HP:0002300)1.86498001
99Cervical subluxation (HP:0003308)1.86118915
100Abnormality of transition element cation homeostasis (HP:0011030)1.85843780
101Recurrent viral infections (HP:0004429)1.85824566
102Cortical dysplasia (HP:0002539)1.85376457
103Autoimmune hemolytic anemia (HP:0001890)1.84795686
104Restrictive lung disease (HP:0002091)1.83589324
105Abnormality of sulfur amino acid metabolism (HP:0004339)1.82891207
106Interstitial pulmonary disease (HP:0006530)1.82788702
107Arterial thrombosis (HP:0004420)1.82289628
108Agammaglobulinemia (HP:0004432)1.82011472
109Axonal loss (HP:0003447)1.81373788
110Spinal muscular atrophy (HP:0007269)1.81323289
111Glomerulopathy (HP:0100820)1.80815523
112Chronic diarrhea (HP:0002028)1.80785398
113Hyperactive renin-angiotensin system (HP:0000841)1.79736870
114Vaginal fistula (HP:0004320)1.77744632
115Myocardial infarction (HP:0001658)1.77635364
116Ascites (HP:0001541)1.76905378
117Distal lower limb muscle weakness (HP:0009053)1.76675963
118Pustule (HP:0200039)1.76065453
119Reticulocytopenia (HP:0001896)1.74681200
120Rectal fistula (HP:0100590)1.74296349
121Rectovaginal fistula (HP:0000143)1.74296349
122Hypoglycemic coma (HP:0001325)1.74257545
123Leukopenia (HP:0001882)1.73807201
124Elevated erythrocyte sedimentation rate (HP:0003565)1.73262570
125Abnormality of glycolipid metabolism (HP:0010969)1.73146010
126Abnormality of liposaccharide metabolism (HP:0010968)1.73146010
127Abnormality of glycosphingolipid metabolism (HP:0004343)1.73146010
128Recurrent skin infections (HP:0001581)1.72454019
129Reduced antithrombin III activity (HP:0001976)1.71091991
130Abnormality of the common coagulation pathway (HP:0010990)1.69793746
131Renal salt wasting (HP:0000127)1.69667781
132Osteomyelitis (HP:0002754)1.68270975
133Rhabdomyosarcoma (HP:0002859)1.68233701
134Intestinal fistula (HP:0100819)1.67500074
135Abnormality of T cell physiology (HP:0011840)1.66971702
136Hepatocellular carcinoma (HP:0001402)1.66163206
137Menorrhagia (HP:0000132)1.64851400
138Petechiae (HP:0000967)1.64820664
139Neoplasm of the oral cavity (HP:0100649)1.63890136
140Generalized aminoaciduria (HP:0002909)1.63785558
141Epistaxis (HP:0000421)1.63446623
142Hematochezia (HP:0002573)1.63016225
143Portal hypertension (HP:0001409)1.62777229
144Nausea (HP:0002018)1.62262418
145Nephritis (HP:0000123)1.62216582
146Medulloblastoma (HP:0002885)1.61513304
147IgA deficiency (HP:0002720)1.60415806
148Delayed puberty (HP:0000823)1.60402547
149Myelodysplasia (HP:0002863)1.60206068
150Hydroxyprolinuria (HP:0003080)1.59693607
151Abnormality of proline metabolism (HP:0010907)1.59693607
152Type I transferrin isoform profile (HP:0003642)1.59460043
153Abnormality of lateral ventricle (HP:0030047)1.59113594
154Retrobulbar optic neuritis (HP:0100654)1.57373105
155Optic neuritis (HP:0100653)1.57373105
156Hyperglycinuria (HP:0003108)1.57276573
157Thrombophlebitis (HP:0004418)1.56930392

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.72594034
2FLT33.07824893
3EPHA23.00163921
4CDK122.24017412
5PKN22.20716832
6FES2.19168752
7FGR2.16250089
8MAP3K142.10296011
9PASK1.99115678
10MAP3K131.98634482
11GRK71.98255382
12MAP4K11.97614777
13TGFBR21.95022741
14STK101.94669503
15BMPR21.92369628
16RPS6KB21.85941775
17TYK21.82730749
18MAPKAPK31.82675862
19WEE11.81719992
20KIT1.76936247
21MAPK151.68469706
22BLK1.66925949
23BRD41.66899536
24NME21.60158832
25TAOK31.59872592
26GRK61.58982713
27JAK31.56692675
28SCYL21.56605470
29PIM11.47505565
30PAK41.46495272
31ERN11.41943450
32TGFBR11.41387204
33PRPF4B1.40810422
34STK41.40239908
35ZAK1.39882474
36IRAK41.37987563
37MST41.36977176
38CSK1.34317247
39IRAK31.33854568
40TTK1.31482779
41NEK91.27993931
42EIF2AK31.25221600
43EEF2K1.22575217
44NEK11.20917374
45CSF1R1.20434298
46FGFR31.19088838
47CDC71.18524039
48ATR1.17956785
49IKBKB1.17560240
50AKT31.16695961
51TNK21.16631151
52EIF2AK11.15843234
53CDK71.15487122
54TEC1.14353720
55IRAK11.12183529
56SIK31.11682717
57BTK1.10006898
58TBK11.10003900
59MAP2K31.09243927
60TSSK61.07355788
61BCKDK1.06773844
62RPS6KA41.06497049
63TXK1.03415466
64ZAP701.02667373
65TESK21.02051284
66NEK21.01825570
67MAP3K80.98471392
68MAP3K10.95590309
69ACVR1B0.95260634
70PIK3CG0.91352045
71MAP3K60.89647447
72KDR0.88408679
73CHUK0.87116184
74JAK10.86199063
75TRPM70.83360224
76YES10.83232648
77MAP3K30.82649281
78CDK40.82639782
79MET0.79892979
80LRRK20.79199946
81MATK0.79108431
82BRSK20.77589415
83PDK20.77364947
84PDK10.75915453
85CDK60.75733615
86MAPK70.75613693
87FRK0.74395771
88IKBKE0.74090674
89AURKB0.72074366
90MAP3K20.71735339
91MAP3K50.71363023
92IRAK20.70672035
93FGFR40.70429696
94PDPK10.66895319
95TTN0.66814566
96PLK10.66373728
97ITK0.65929587
98JAK20.65480546
99TIE10.65347321
100LCK0.65268564
101CDC42BPA0.64818976
102EPHB10.64306623
103ERBB40.63547582
104PIM20.62832919
105MAP3K110.62686935
106LYN0.62241256
107CAMKK20.61238714
108SRPK10.61009613
109ABL10.60848222
110KSR20.60667318
111HCK0.60360140
112VRK10.59394787
113NLK0.59232961
114TAOK20.58763648
115TESK10.58717307
116ATM0.57564592
117TAOK10.57036088
118STK30.55461835
119EIF2AK20.52924473
120RIPK10.51923593
121MAP2K60.51726445
122PRKG20.51224652
123MOS0.50779447
124DDR20.50178804
125RET0.49995824
126STK38L0.49857020
127PTK60.49109945
128MARK20.48656641
129FYN0.48637218
130MARK30.48464945
131CHEK20.48260149
132MST1R0.48174922
133SYK0.48061101
134WNK30.47664262
135RPS6KA60.46745435
136BMX0.46671892
137RPS6KC10.43236153
138RPS6KL10.43236153
139CAMK1D0.42383331
140CDK190.41682288
141SGK30.39364449
142EGFR0.39238997
143PRKCQ0.38775827
144PDGFRB0.38680401
145EPHA30.38074009
146NEK60.37689043
147HIPK20.37069719
148FER0.35568376

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006702.98259813
2DNA replication_Homo sapiens_hsa030302.49371185
3Asthma_Homo sapiens_hsa053102.37913296
4Mismatch repair_Homo sapiens_hsa034302.34270662
5Staphylococcus aureus infection_Homo sapiens_hsa051502.23046119
6Autoimmune thyroid disease_Homo sapiens_hsa053202.13176280
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.00935397
8* Other glycan degradation_Homo sapiens_hsa005111.96274182
9Rheumatoid arthritis_Homo sapiens_hsa053231.91265708
10Type I diabetes mellitus_Homo sapiens_hsa049401.83984900
11Antigen processing and presentation_Homo sapiens_hsa046121.67747084
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66143596
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65539256
14Selenocompound metabolism_Homo sapiens_hsa004501.63387355
15Homologous recombination_Homo sapiens_hsa034401.56309492
16Legionellosis_Homo sapiens_hsa051341.52157097
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.51271507
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50567226
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50429598
20Non-homologous end-joining_Homo sapiens_hsa034501.49988198
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.48601178
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48404893
23Leishmaniasis_Homo sapiens_hsa051401.45872863
24Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.45847120
25Base excision repair_Homo sapiens_hsa034101.45418568
26* Lysosome_Homo sapiens_hsa041421.43781680
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.39967134
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37885644
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37291376
30Complement and coagulation cascades_Homo sapiens_hsa046101.33534451
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29614247
32Acute myeloid leukemia_Homo sapiens_hsa052211.27987987
33Nucleotide excision repair_Homo sapiens_hsa034201.27871327
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27283466
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26849155
36Folate biosynthesis_Homo sapiens_hsa007901.25243849
37Platelet activation_Homo sapiens_hsa046111.24868313
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18126361
39African trypanosomiasis_Homo sapiens_hsa051431.17459876
40Chemokine signaling pathway_Homo sapiens_hsa040621.17437000
41Measles_Homo sapiens_hsa051621.12542998
42Biosynthesis of amino acids_Homo sapiens_hsa012301.09549410
43Herpes simplex infection_Homo sapiens_hsa051681.09182570
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.08236340
45Fanconi anemia pathway_Homo sapiens_hsa034601.04045907
46RNA transport_Homo sapiens_hsa030131.03889302
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01972934
48Amoebiasis_Homo sapiens_hsa051461.00149096
49T cell receptor signaling pathway_Homo sapiens_hsa046600.99495408
50Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98880636
51Salmonella infection_Homo sapiens_hsa051320.98779765
52Pyrimidine metabolism_Homo sapiens_hsa002400.97772352
53p53 signaling pathway_Homo sapiens_hsa041150.96927062
54Tryptophan metabolism_Homo sapiens_hsa003800.96046425
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.96005528
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95189317
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94447233
58Hematopoietic cell lineage_Homo sapiens_hsa046400.93518121
59Apoptosis_Homo sapiens_hsa042100.93248133
60beta-Alanine metabolism_Homo sapiens_hsa004100.92782569
61Cell cycle_Homo sapiens_hsa041100.90268416
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.88725955
63Hepatitis C_Homo sapiens_hsa051600.88395260
64Galactose metabolism_Homo sapiens_hsa000520.88259980
65Lysine degradation_Homo sapiens_hsa003100.86960910
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86713182
67Influenza A_Homo sapiens_hsa051640.86654639
68Pentose phosphate pathway_Homo sapiens_hsa000300.86289586
69Peroxisome_Homo sapiens_hsa041460.85843539
70Starch and sucrose metabolism_Homo sapiens_hsa005000.85423778
71Systemic lupus erythematosus_Homo sapiens_hsa053220.85145337
72Renin-angiotensin system_Homo sapiens_hsa046140.85131227
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84827395
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83266239
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83019329
76Spliceosome_Homo sapiens_hsa030400.83003174
77Malaria_Homo sapiens_hsa051440.82606239
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82305216
79Arginine biosynthesis_Homo sapiens_hsa002200.81783047
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.81321224
81Pancreatic cancer_Homo sapiens_hsa052120.80484237
82Osteoclast differentiation_Homo sapiens_hsa043800.80396537
83RNA polymerase_Homo sapiens_hsa030200.80068055
84Pertussis_Homo sapiens_hsa051330.79351851
85Vitamin digestion and absorption_Homo sapiens_hsa049770.78570767
86Caffeine metabolism_Homo sapiens_hsa002320.77749683
87Primary immunodeficiency_Homo sapiens_hsa053400.77729228
88Shigellosis_Homo sapiens_hsa051310.77696278
89Carbon metabolism_Homo sapiens_hsa012000.77650706
90RNA degradation_Homo sapiens_hsa030180.77423486
91Fatty acid degradation_Homo sapiens_hsa000710.77169879
92Non-small cell lung cancer_Homo sapiens_hsa052230.76514525
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76474851
94Tuberculosis_Homo sapiens_hsa051520.75298019
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.73464698
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73135506
97Viral carcinogenesis_Homo sapiens_hsa052030.71867813
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71412090
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70442977
100Histidine metabolism_Homo sapiens_hsa003400.69652057
101Prolactin signaling pathway_Homo sapiens_hsa049170.69100508
102Chronic myeloid leukemia_Homo sapiens_hsa052200.66618855
103Toxoplasmosis_Homo sapiens_hsa051450.66065688
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65800119
105Small cell lung cancer_Homo sapiens_hsa052220.65680573
106Allograft rejection_Homo sapiens_hsa053300.63556211
107Fructose and mannose metabolism_Homo sapiens_hsa000510.61705530
108Phagosome_Homo sapiens_hsa041450.60937022
109Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60890344
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60761789
111Graft-versus-host disease_Homo sapiens_hsa053320.60692832
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60134228
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59618193
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.59557242
115Glutathione metabolism_Homo sapiens_hsa004800.59462711
116Jak-STAT signaling pathway_Homo sapiens_hsa046300.58913066
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.58894696
118B cell receptor signaling pathway_Homo sapiens_hsa046620.58093910
119Arginine and proline metabolism_Homo sapiens_hsa003300.57849898
120ABC transporters_Homo sapiens_hsa020100.57446407
121HIF-1 signaling pathway_Homo sapiens_hsa040660.56017922
122VEGF signaling pathway_Homo sapiens_hsa043700.55367287
123Notch signaling pathway_Homo sapiens_hsa043300.55235316
124Sphingolipid metabolism_Homo sapiens_hsa006000.52652824
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.52540671
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51840704
127Epstein-Barr virus infection_Homo sapiens_hsa051690.51392073
128Renal cell carcinoma_Homo sapiens_hsa052110.51197989
129TNF signaling pathway_Homo sapiens_hsa046680.51022558
130mTOR signaling pathway_Homo sapiens_hsa041500.50499105
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.48566025
132Hepatitis B_Homo sapiens_hsa051610.46473880
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45992511
134Endocytosis_Homo sapiens_hsa041440.45650565
135Collecting duct acid secretion_Homo sapiens_hsa049660.45633411
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45584035
137Bladder cancer_Homo sapiens_hsa052190.45540505
138Endometrial cancer_Homo sapiens_hsa052130.45496919
139Insulin resistance_Homo sapiens_hsa049310.45412241
140Viral myocarditis_Homo sapiens_hsa054160.43161416
141FoxO signaling pathway_Homo sapiens_hsa040680.42585966
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39027971
143Inositol phosphate metabolism_Homo sapiens_hsa005620.33011461
144HTLV-I infection_Homo sapiens_hsa051660.32951707
145Dorso-ventral axis formation_Homo sapiens_hsa043200.32724553
146Phospholipase D signaling pathway_Homo sapiens_hsa040720.32057976
147Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31666085
148Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31474070
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31030762
150Proteoglycans in cancer_Homo sapiens_hsa052050.30369821
151Choline metabolism in cancer_Homo sapiens_hsa052310.28752444
152Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28407595
153Mineral absorption_Homo sapiens_hsa049780.27429931

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