MANBAL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcription from mitochondrial promoter (GO:0006390)8.84654370
2proline metabolic process (GO:0006560)8.61971080
3replication fork processing (GO:0031297)7.59272802
4embryonic process involved in female pregnancy (GO:0060136)7.52897785
5positive regulation of protein homooligomerization (GO:0032464)7.26335708
6DNA deamination (GO:0045006)7.03601778
7establishment of apical/basal cell polarity (GO:0035089)6.43910949
8regulation of protein homooligomerization (GO:0032462)6.43671244
9regulation of integrin activation (GO:0033623)6.36338473
10oxidative demethylation (GO:0070989)6.26187331
11maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.05593775
12establishment of monopolar cell polarity (GO:0061162)5.67210157
13establishment or maintenance of monopolar cell polarity (GO:0061339)5.67210157
14negative regulation of JAK-STAT cascade (GO:0046426)5.63878174
15establishment of protein localization to mitochondrial membrane (GO:0090151)5.30956964
16DNA strand renaturation (GO:0000733)5.24531857
17mitochondrial DNA metabolic process (GO:0032042)5.18749068
18cellular response to ATP (GO:0071318)4.99821586
19negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.96229392
20somatic diversification of immune receptors via somatic mutation (GO:0002566)4.89492417
21somatic hypermutation of immunoglobulin genes (GO:0016446)4.89492417
22poly(A)+ mRNA export from nucleus (GO:0016973)4.88466412
23viral mRNA export from host cell nucleus (GO:0046784)4.85174369
24mitotic G1 DNA damage checkpoint (GO:0031571)4.70988321
25COPI coating of Golgi vesicle (GO:0048205)4.68665058
26Golgi transport vesicle coating (GO:0048200)4.68665058
27negative regulation of cell cycle arrest (GO:0071157)4.60895078
28protein maturation by protein folding (GO:0022417)4.60643094
29negative regulation of protein oligomerization (GO:0032460)4.45455685
30protein retention in ER lumen (GO:0006621)4.43478886
31positive regulation of developmental pigmentation (GO:0048087)4.38478299
32glutamine family amino acid biosynthetic process (GO:0009084)4.32324962
33formation of translation preinitiation complex (GO:0001731)4.31134579
34embryonic placenta development (GO:0001892)4.28712954
35negative regulation of Ras GTPase activity (GO:0034261)4.27580426
36maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.25497390
37G1 DNA damage checkpoint (GO:0044783)4.24213823
38cellular response to zinc ion (GO:0071294)4.23155994
39DNA integration (GO:0015074)4.20873736
40mitotic G1/S transition checkpoint (GO:0044819)4.17234417
41glial cell migration (GO:0008347)4.11347639
42regulation of translational fidelity (GO:0006450)4.10279440
43positive regulation of protein oligomerization (GO:0032461)4.08988491
44mRNA cleavage (GO:0006379)4.04890157
45regulation of protein oligomerization (GO:0032459)4.02372131
46GDP-mannose metabolic process (GO:0019673)4.00813548
47regulation of mitochondrial translation (GO:0070129)4.00159087
48negative regulation of heart rate (GO:0010459)3.92824422
49base-excision repair (GO:0006284)3.91865254
50establishment of viral latency (GO:0019043)3.87738216
51spliceosomal tri-snRNP complex assembly (GO:0000244)3.85524058
52chaperone-mediated protein transport (GO:0072321)3.83892892
53establishment of integrated proviral latency (GO:0075713)3.79759649
54pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.79009189
55convergent extension (GO:0060026)3.77734117
56negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.72859789
57face development (GO:0060324)3.72050504
58embryonic camera-type eye development (GO:0031076)3.70201621
59apoptotic process involved in morphogenesis (GO:0060561)3.68119515
60telomere maintenance via semi-conservative replication (GO:0032201)3.66435449
61negative regulation of fatty acid biosynthetic process (GO:0045717)3.66335134
62positive regulation by host of viral transcription (GO:0043923)3.65101722
63labyrinthine layer development (GO:0060711)3.60819674
64mitochondrial RNA metabolic process (GO:0000959)3.60327202
65base-excision repair, AP site formation (GO:0006285)3.58424390
66non-recombinational repair (GO:0000726)3.56969393
67double-strand break repair via nonhomologous end joining (GO:0006303)3.56969393
68nuclear envelope reassembly (GO:0031468)3.54189609
69mitotic nuclear envelope reassembly (GO:0007084)3.54189609
70regulation of cAMP-dependent protein kinase activity (GO:2000479)3.52674249
71nucleotide-excision repair, DNA gap filling (GO:0006297)3.51518539
72DNA double-strand break processing (GO:0000729)3.46666724
73anatomical structure regression (GO:0060033)3.46434673
74histone H4-K12 acetylation (GO:0043983)3.41475223
75auditory receptor cell stereocilium organization (GO:0060088)3.38976312
76positive regulation of DNA repair (GO:0045739)3.38585786
77mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.38076980
78proteasome assembly (GO:0043248)3.37432014
79signal complex assembly (GO:0007172)3.36319010
80synaptic vesicle endocytosis (GO:0048488)3.32373338
81respiratory system process (GO:0003016)3.30797253
82negative regulation of mRNA processing (GO:0050686)3.28314170
83regulation of mitochondrial depolarization (GO:0051900)3.28227981
84cullin deneddylation (GO:0010388)3.27107214
85trophectodermal cell differentiation (GO:0001829)3.26126964
86deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.25933800
87positive regulation of receptor recycling (GO:0001921)3.25669005
88activation of Rac GTPase activity (GO:0032863)3.25206505
89maturation of 5.8S rRNA (GO:0000460)3.25055878
90regulation of glomerular filtration (GO:0003093)3.23997011
91negative regulation of appetite (GO:0032099)3.23950960
92negative regulation of response to food (GO:0032096)3.23950960
93protein targeting to lysosome (GO:0006622)3.23062917
94establishment of protein localization to vacuole (GO:0072666)3.23062917
95protein targeting to vacuole (GO:0006623)3.23062917
96regulation of early endosome to late endosome transport (GO:2000641)3.21845413
97termination of RNA polymerase II transcription (GO:0006369)3.21235864
98regulation of podosome assembly (GO:0071801)3.18309946
99regulation of response to reactive oxygen species (GO:1901031)3.17926906
100negative regulation of tumor necrosis factor production (GO:0032720)3.15612748
101dosage compensation (GO:0007549)3.12697056
102DNA ligation (GO:0006266)3.11046525
103regulation of double-strand break repair via homologous recombination (GO:0010569)3.10880383
104type B pancreatic cell proliferation (GO:0044342)3.09170192
105nodal signaling pathway (GO:0038092)3.09144533
106regulation of cell size (GO:0008361)3.08582969
107cell migration in hindbrain (GO:0021535)3.04861551
108pyrimidine nucleotide catabolic process (GO:0006244)3.04392850
109protein neddylation (GO:0045116)3.04096731
110negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.03775179
111mRNA polyadenylation (GO:0006378)3.03012893
112alkaloid metabolic process (GO:0009820)3.02982806
113lipopolysaccharide biosynthetic process (GO:0009103)2.91182755
114positive regulation of mitochondrial fission (GO:0090141)2.88720764
115retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.88702793
116energy coupled proton transport, down electrochemical gradient (GO:0015985)2.88231286
117ATP synthesis coupled proton transport (GO:0015986)2.88231286
118peptidyl-arginine omega-N-methylation (GO:0035247)2.83331363
119protein deneddylation (GO:0000338)2.71874453
120L-serine metabolic process (GO:0006563)2.70480612
121mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.67808669
122negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.66533411
123erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.62787141
124L-phenylalanine metabolic process (GO:0006558)2.62787141
125protein complex biogenesis (GO:0070271)2.62561939
126negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.59555091
127GTP biosynthetic process (GO:0006183)2.59151275
128pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.58474782
129protein insertion into membrane (GO:0051205)2.57938936
130regulation of cellular amino acid metabolic process (GO:0006521)2.57884344
131protein targeting to mitochondrion (GO:0006626)2.56535867
132guanosine-containing compound biosynthetic process (GO:1901070)2.56288210
133daunorubicin metabolic process (GO:0044597)2.55093775
134polyketide metabolic process (GO:0030638)2.55093775
135doxorubicin metabolic process (GO:0044598)2.55093775
136cellular copper ion homeostasis (GO:0006878)2.54251413
137muscle cell migration (GO:0014812)2.53583200
1384-hydroxyproline metabolic process (GO:0019471)2.52748824
139positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.52180816
140respiratory electron transport chain (GO:0022904)2.51644269
141negative regulation of ligase activity (GO:0051352)2.49379595
142negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.49379595
143nucleobase-containing small molecule interconversion (GO:0015949)2.48792135
144L-serine transport (GO:0015825)2.47709301
145mitochondrial respiratory chain complex assembly (GO:0033108)2.46566646
146de novo posttranslational protein folding (GO:0051084)2.46526230
147electron transport chain (GO:0022900)2.45856802
148de novo protein folding (GO:0006458)2.43621103
149UTP biosynthetic process (GO:0006228)2.43222406
150establishment of protein localization to mitochondrion (GO:0072655)2.41206135
151adenine nucleotide transport (GO:0051503)2.40659105
152positive regulation of TOR signaling (GO:0032008)2.40466462
153positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.39772350
154peptidyl-proline hydroxylation (GO:0019511)2.39680524
155histone arginine methylation (GO:0034969)2.38159147
156positive regulation of actin filament depolymerization (GO:0030836)2.37731553
157extracellular fibril organization (GO:0043206)2.36219530
158CTP metabolic process (GO:0046036)2.35595704
159CTP biosynthetic process (GO:0006241)2.35595704
160deoxyribose phosphate biosynthetic process (GO:0046385)2.34761242
1612-deoxyribonucleotide biosynthetic process (GO:0009265)2.34761242
162sequestering of actin monomers (GO:0042989)2.34251770
163protein localization to mitochondrion (GO:0070585)2.33433872
164skin morphogenesis (GO:0043589)2.32309106
165fatty acid elongation (GO:0030497)2.32104627
166protein hydroxylation (GO:0018126)2.31855619
167barbed-end actin filament capping (GO:0051016)2.31825992
168regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.31765274
169peptidyl-histidine modification (GO:0018202)2.31574675
170pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.29177919
171endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.28856575
172pentose-phosphate shunt (GO:0006098)2.28525395
173regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.28078583
174gluconeogenesis (GO:0006094)2.26571234
175metallo-sulfur cluster assembly (GO:0031163)2.26469407
176iron-sulfur cluster assembly (GO:0016226)2.26469407
177glycolytic process (GO:0006096)2.25822268
178pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.25400163
179virion assembly (GO:0019068)2.24741754
180glucose catabolic process (GO:0006007)2.24398124
181positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.23336649
182anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.23167033
183peptidyl-arginine methylation (GO:0018216)2.22312910
184peptidyl-arginine N-methylation (GO:0035246)2.22312910
185mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.22078410
186amyloid precursor protein catabolic process (GO:0042987)2.20874002
187regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.19506339
188DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.19320951
189prostanoid biosynthetic process (GO:0046457)2.19310254
190prostaglandin biosynthetic process (GO:0001516)2.19310254
191NADPH regeneration (GO:0006740)2.19008715
192proline biosynthetic process (GO:0006561)11.5230696

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.56772635
2ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.59552024
3SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.35335227
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.27708156
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.27708156
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.27708156
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.03045923
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.02293893
9SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.68442826
10SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.68406301
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.68158851
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.58502956
13ERG_21242973_ChIP-ChIP_JURKAT_Human2.55327320
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.44608241
15NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.44507686
16KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.41973518
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.37865575
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.32763565
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.31242376
20LXR_22292898_ChIP-Seq_THP-1_Human2.28838952
21VDR_21846776_ChIP-Seq_THP-1_Human2.27757308
22* GABP_17652178_ChIP-ChIP_JURKAT_Human2.26711901
23POU5F1_16518401_ChIP-PET_MESCs_Mouse2.24837564
24* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.21263627
25TP63_17297297_ChIP-ChIP_HaCaT_Human2.21231524
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15990910
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.13822159
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.12693100
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.09646759
30XRN2_22483619_ChIP-Seq_HELA_Human2.07357781
31NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.04109927
32TCF3_18692474_ChIP-Seq_MESCs_Mouse2.02874144
33MYC_19079543_ChIP-ChIP_MESCs_Mouse2.01946914
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98594109
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.96603207
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96215063
37CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.94998138
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94884989
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.90533627
40PU.1_20513432_ChIP-Seq_Bcells_Mouse1.89292831
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.87928984
42DCP1A_22483619_ChIP-Seq_HELA_Human1.84805634
43TCF3_18692474_ChIP-Seq_MEFs_Mouse1.83143341
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.80099614
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.77530630
46NANOG_21062744_ChIP-ChIP_HESCs_Human1.74674259
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.72526968
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.70721840
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68690527
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.66951521
51NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.65806879
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.64908018
53EST1_17652178_ChIP-ChIP_JURKAT_Human1.64499671
54ZNF263_19887448_ChIP-Seq_K562_Human1.62054883
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.60465500
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.59848145
57CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.58481094
58RACK7_27058665_Chip-Seq_MCF-7_Human1.56486316
59* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56407758
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.55950719
61* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.54354562
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.52889547
63CTCF_18555785_ChIP-Seq_MESCs_Mouse1.52771497
64MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51124059
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.47911184
66POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.46527439
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46144917
68TTF2_22483619_ChIP-Seq_HELA_Human1.45563285
69* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.44979267
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44168154
71NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.42586430
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.41656231
73* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39673619
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38787752
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37916195
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37735720
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36696906
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36300323
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35507869
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35187758
81SOX2_18692474_ChIP-Seq_MEFs_Mouse1.34908167
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34365824
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33573294
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32292409
85NANOG_18692474_ChIP-Seq_MESCs_Mouse1.31867574
86OCT4_18692474_ChIP-Seq_MEFs_Mouse1.29953101
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29500407
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29052490
89ETS1_21867929_ChIP-Seq_TH2_Mouse1.26709788
90SOX2_18692474_ChIP-Seq_MESCs_Mouse1.26646280
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.26557252
92TP53_20018659_ChIP-ChIP_R1E_Mouse1.26027447
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.25858371
94RARB_24833708_ChIP-Seq_LIVER_Mouse1.25774194
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25291669
96ETS1_20019798_ChIP-Seq_JURKAT_Human1.24678072
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24595776
98RXRA_24833708_ChIP-Seq_LIVER_Mouse1.23625200
99* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.23579929
100CLOCK_20551151_ChIP-Seq_293T_Human1.22510192
101MYC_22102868_ChIP-Seq_BL_Human1.21616012
102KDM2B_26808549_Chip-Seq_DND41_Human1.21276861
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20804801
104CTCF_21964334_ChIP-Seq_BJAB-B_Human1.20771868
105STAT1_20625510_ChIP-Seq_HELA_Human1.20456533
106SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19948229
107SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19079733
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19022585
109ELK3_25401928_ChIP-Seq_HUVEC_Human1.18361649
110PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.17524406
111TBX5_21415370_ChIP-Seq_HL-1_Mouse1.17369938
112FOXP1_21924763_ChIP-Seq_HESCs_Human1.16143994
113CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15825016
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15665998
115CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15129116
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14813192
117FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.14641648
118POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14497252
119YY1_22570637_ChIP-Seq_MALME-3M_Human1.13899483
120CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13590312
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13037698
122BCOR_27268052_Chip-Seq_Bcells_Human1.11612462
123SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11000881
124MYCN_18555785_ChIP-Seq_MESCs_Mouse1.10424755
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10322746
126KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09680610
127ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09124549
128SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08976385
129TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.08474250
130TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.07954765
131CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07386810
132NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06874200
133EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06651669
134NANOG_18692474_ChIP-Seq_MEFs_Mouse1.06121182
135CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05471477
136RARA_24833708_ChIP-Seq_LIVER_Mouse1.05093329
137ATF3_27146783_Chip-Seq_COLON_Human1.04853741
138* GABP_19822575_ChIP-Seq_HepG2_Human1.04622187
139SA1_27219007_Chip-Seq_ERYTHROID_Human1.04548065
140ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03819099
141E2F1_20622854_ChIP-Seq_HELA_Human1.03366603
142PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03112515
143HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.03038587
144PHF8_20622854_ChIP-Seq_HELA_Human1.02662930
145KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02059965
146SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02034156
147* SPI1_26923725_Chip-Seq_HPCs_Mouse1.01880629
148TP53_22127205_ChIP-Seq_IMR90_Human1.01291386
149TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00892257
150SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00638657
151TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.00522927
152SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00057394
153ELK1_22589737_ChIP-Seq_MCF10A_Human0.99065940
154SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96687715
155ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96152270
156P68_20966046_ChIP-Seq_HELA_Human0.95886422
157RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95531748
158CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94644087
159ELF1_20517297_ChIP-Seq_JURKAT_Human0.93773124
160TET1_21490601_ChIP-Seq_MESCs_Mouse0.93182429

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.01688598
2MP0005171_absent_coat_pigmentation5.44385216
3MP0009278_abnormal_bone_marrow4.51356558
4MP0010030_abnormal_orbit_morphology4.10260712
5MP0004233_abnormal_muscle_weight3.85224714
6MP0002009_preneoplasia3.25629984
7MP0002653_abnormal_ependyma_morphology2.90960795
8MP0004133_heterotaxia2.64421760
9MP0008995_early_reproductive_senescence2.59243488
10MP0008438_abnormal_cutaneous_collagen2.52668371
11MP0003283_abnormal_digestive_organ2.48795346
12MP0005257_abnormal_intraocular_pressure2.47575507
13MP0004272_abnormal_basement_membrane2.34877580
14MP0006072_abnormal_retinal_apoptosis2.26606235
15MP0003890_abnormal_embryonic-extraembry2.20603402
16MP0008789_abnormal_olfactory_epithelium2.18754021
17MP0003119_abnormal_digestive_system2.14601627
18MP0001545_abnormal_hematopoietic_system2.05372777
19MP0005397_hematopoietic_system_phenotyp2.05372777
20MP0003123_paternal_imprinting2.01714599
21MP0002249_abnormal_larynx_morphology1.96786194
22MP0002282_abnormal_trachea_morphology1.93801082
23MP0008260_abnormal_autophagy1.93577845
24MP0003186_abnormal_redox_activity1.92257599
25MP0005174_abnormal_tail_pigmentation1.89239385
26MP0003786_premature_aging1.84156637
27MP0003453_abnormal_keratinocyte_physiol1.82662332
28MP0005058_abnormal_lysosome_morphology1.73844652
29MP0005499_abnormal_olfactory_system1.72748960
30MP0005394_taste/olfaction_phenotype1.72748960
31MP0008877_abnormal_DNA_methylation1.69015025
32MP0003122_maternal_imprinting1.68439340
33MP0000566_synostosis1.64278667
34MP0000579_abnormal_nail_morphology1.64085919
35MP0000462_abnormal_digestive_system1.62932095
36MP0003172_abnormal_lysosome_physiology1.59051027
37MP0004859_abnormal_synaptic_plasticity1.55091926
38MP0004957_abnormal_blastocyst_morpholog1.54423665
39MP0009780_abnormal_chondrocyte_physiolo1.54212360
40MP0003806_abnormal_nucleotide_metabolis1.53765726
41MP0008932_abnormal_embryonic_tissue1.52084587
42MP0001293_anophthalmia1.50537329
43MP0004858_abnormal_nervous_system1.50351558
44MP0009053_abnormal_anal_canal1.48513387
45MP0005076_abnormal_cell_differentiation1.47689421
46MP0010094_abnormal_chromosome_stability1.46065628
47MP0001849_ear_inflammation1.44684971
48MP0002084_abnormal_developmental_patter1.42970213
49MP0000639_abnormal_adrenal_gland1.42483076
50MP0003191_abnormal_cellular_cholesterol1.42391073
51MP0001299_abnormal_eye_distance/1.41205024
52MP0000015_abnormal_ear_pigmentation1.41197324
53MP0003705_abnormal_hypodermis_morpholog1.37690049
54MP0002269_muscular_atrophy1.37068346
55MP0003566_abnormal_cell_adhesion1.36323995
56MP0000750_abnormal_muscle_regeneration1.35016763
57MP0005645_abnormal_hypothalamus_physiol1.34532258
58MP0001697_abnormal_embryo_size1.33420479
59MP0002086_abnormal_extraembryonic_tissu1.32825679
60MP0004142_abnormal_muscle_tone1.32053341
61MP0000762_abnormal_tongue_morphology1.31659475
62MP0001340_abnormal_eyelid_morphology1.30816538
63MP0000470_abnormal_stomach_morphology1.30093926
64MP0010352_gastrointestinal_tract_polyps1.29871501
65MP0005075_abnormal_melanosome_morpholog1.28672674
66MP0003329_amyloid_beta_deposits1.28279451
67MP0009840_abnormal_foam_cell1.27921501
68MP0002085_abnormal_embryonic_tissue1.27080875
69MP0001529_abnormal_vocalization1.26718152
70MP0003567_abnormal_fetal_cardiomyocyte1.26121212
71MP0002234_abnormal_pharynx_morphology1.23934852
72MP0002796_impaired_skin_barrier1.19628823
73MP0004197_abnormal_fetal_growth/weight/1.17029040
74MP0002295_abnormal_pulmonary_circulatio1.16584768
75MP0002736_abnormal_nociception_after1.15697352
76MP0009379_abnormal_foot_pigmentation1.15558919
77MP0002111_abnormal_tail_morphology1.15492701
78MP0001542_abnormal_bone_strength1.15178396
79MP0000678_abnormal_parathyroid_gland1.14974609
80MP0001346_abnormal_lacrimal_gland1.13830184
81MP0001905_abnormal_dopamine_level1.12222957
82MP0002233_abnormal_nose_morphology1.10802120
83MP0000490_abnormal_crypts_of1.07092586
84MP0003137_abnormal_impulse_conducting1.06409093
85MP0000749_muscle_degeneration1.06022273
86MP0000537_abnormal_urethra_morphology1.05145946
87MP0003755_abnormal_palate_morphology1.04728318
88MP0006054_spinal_hemorrhage1.03181040
89MP0000371_diluted_coat_color1.03125277
90MP0000358_abnormal_cell_content/1.03118398
91MP0002932_abnormal_joint_morphology1.02849181
92MP0008058_abnormal_DNA_repair0.99499431
93MP0010234_abnormal_vibrissa_follicle0.99272716
94MP0000343_altered_response_to0.99185670
95MP0010368_abnormal_lymphatic_system0.98826745
96MP0001958_emphysema0.97199845
97MP0008875_abnormal_xenobiotic_pharmacok0.96000121
98MP0000534_abnormal_ureter_morphology0.94926800
99MP0005408_hypopigmentation0.94442064
100MP0003950_abnormal_plasma_membrane0.93824986
101MP0002733_abnormal_thermal_nociception0.92505400
102MP0002332_abnormal_exercise_endurance0.92484045
103MP0002114_abnormal_axial_skeleton0.91572851
104MP0003828_pulmonary_edema0.91536347
105MP0000955_abnormal_spinal_cord0.90349307
106MP0003880_abnormal_central_pattern0.89869519
107MP0002116_abnormal_craniofacial_bone0.88684234
108MP0004270_analgesia0.87559672
109MP0003279_aneurysm0.86972969
110MP0005380_embryogenesis_phenotype0.86957899
111MP0001672_abnormal_embryogenesis/_devel0.86957899
112MP0002697_abnormal_eye_size0.86886080
113MP0002751_abnormal_autonomic_nervous0.86755932
114MP0006035_abnormal_mitochondrial_morpho0.85486500
115MP0005197_abnormal_uvea_morphology0.84891513
116MP0006082_CNS_inflammation0.84385725
117MP0001984_abnormal_olfaction0.84169551
118MP0003045_fibrosis0.84060737
119MP0006036_abnormal_mitochondrial_physio0.83954546
120MP0003111_abnormal_nucleus_morphology0.83460218
121MP0005330_cardiomyopathy0.83253487
122MP0005508_abnormal_skeleton_morphology0.83072831
123MP0000467_abnormal_esophagus_morphology0.82813574
124MP0005023_abnormal_wound_healing0.82562898
125MP0001970_abnormal_pain_threshold0.82500294
126MP0001270_distended_abdomen0.81946037
127MP0004134_abnormal_chest_morphology0.81148510
128MP0009384_cardiac_valve_regurgitation0.80788982
129MP0008007_abnormal_cellular_replicative0.80674203
130MP0003935_abnormal_craniofacial_develop0.80306292
131MP0003136_yellow_coat_color0.79599367
132MP0005266_abnormal_metabolism0.79228229
133MP0003938_abnormal_ear_development0.78835080
134MP0002089_abnormal_postnatal_growth/wei0.77747851
135MP0010771_integument_phenotype0.77712197
136MP0002080_prenatal_lethality0.77143542
137MP0000647_abnormal_sebaceous_gland0.76483792
138MP0002060_abnormal_skin_morphology0.76166203
139MP0005165_increased_susceptibility_to0.76157662
140MP0002938_white_spotting0.76157352
141MP0009046_muscle_twitch0.75731504
142MP0000049_abnormal_middle_ear0.75577123
143MP0000778_abnormal_nervous_system0.75161318
144MP0000350_abnormal_cell_proliferation0.74861379
145MP0002177_abnormal_outer_ear0.74847234
146MP0002090_abnormal_vision0.74561468
147MP0001348_abnormal_lacrimal_gland0.74058811
148MP0001730_embryonic_growth_arrest0.73939946
149MP0003011_delayed_dark_adaptation0.72517023
150MP0000751_myopathy0.72089893
151MP0002075_abnormal_coat/hair_pigmentati0.72009186
152MP0003656_abnormal_erythrocyte_physiolo0.71523516
153MP0003634_abnormal_glial_cell0.71451017
154MP0000747_muscle_weakness0.71251852
155MP0009115_abnormal_fat_cell0.70913799
156MP0002572_abnormal_emotion/affect_behav0.70867891
157MP0003937_abnormal_limbs/digits/tail_de0.70181367
158MP0000163_abnormal_cartilage_morphology0.69616794
159MP0000681_abnormal_thyroid_gland0.69491123
160MP0000003_abnormal_adipose_tissue0.69381264
161MP0002019_abnormal_tumor_incidence0.68474935
162MP0005253_abnormal_eye_physiology0.68231752
163MP0005501_abnormal_skin_physiology0.67830964
164MP0003385_abnormal_body_wall0.67819204
165MP0001324_abnormal_eye_pigmentation0.67650214
166MP0003718_maternal_effect0.65199405
167MP0005623_abnormal_meninges_morphology0.64962262
168MP0003942_abnormal_urinary_system0.62565394
169MP0000432_abnormal_head_morphology0.62482509
170MP0000685_abnormal_immune_system0.61912877
171MP0005367_renal/urinary_system_phenotyp0.61845503
172MP0000516_abnormal_urinary_system0.61845503

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)5.86838050
2Rib fusion (HP:0000902)5.51668553
3Annular pancreas (HP:0001734)5.17937436
4Increased IgM level (HP:0003496)4.95845067
5Turricephaly (HP:0000262)4.91982795
6Rectovaginal fistula (HP:0000143)4.91619966
7Rectal fistula (HP:0100590)4.91619966
8Pustule (HP:0200039)4.82124528
9Facial hemangioma (HP:0000329)4.70802520
10Alopecia of scalp (HP:0002293)4.51815998
11Vaginal fistula (HP:0004320)4.35127413
12Intestinal fistula (HP:0100819)4.26511137
13Abnormal hemoglobin (HP:0011902)4.19218695
14Ulnar bowing (HP:0003031)4.15439448
15Coronal craniosynostosis (HP:0004440)4.11544010
16Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.03161523
17Tongue fasciculations (HP:0001308)4.00855507
18Poikiloderma (HP:0001029)3.97108937
19Hypochromic microcytic anemia (HP:0004840)3.92041529
20Premature rupture of membranes (HP:0001788)3.89832553
21Orthostatic hypotension (HP:0001278)3.87590167
22Muscle fibrillation (HP:0010546)3.70357552
23Alacrima (HP:0000522)3.62383733
24Anteriorly placed anus (HP:0001545)3.57416654
25Short humerus (HP:0005792)3.49239780
26Male infertility (HP:0003251)3.46054506
27Aplasia/hypoplasia of the humerus (HP:0006507)3.45523800
28Dysautonomia (HP:0002459)3.43366124
29Short nail (HP:0001799)3.42009734
30Intestinal atresia (HP:0011100)3.41607179
31Protrusio acetabuli (HP:0003179)3.39399578
32Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.31669458
33Vertebral hypoplasia (HP:0008417)3.31669458
34Abnormality of the aortic arch (HP:0012303)3.28735761
35Vertebral compression fractures (HP:0002953)3.27865864
36Premature skin wrinkling (HP:0100678)3.25472024
37Congenital hip dislocation (HP:0001374)3.24994684
38Growth hormone excess (HP:0000845)3.18651448
39Mucopolysacchariduria (HP:0008155)3.15333690
40Urinary glycosaminoglycan excretion (HP:0003541)3.15333690
41Large for gestational age (HP:0001520)3.14507472
42Hypotrichosis (HP:0001006)3.10763916
43Short chin (HP:0000331)3.10655199
44Abnormality of dentin (HP:0010299)3.09257352
45Abnormality of male internal genitalia (HP:0000022)3.09085813
46Diaphragmatic weakness (HP:0009113)3.07918271
47Dysostosis multiplex (HP:0000943)3.06953229
48Abnormal mitochondria in muscle tissue (HP:0008316)2.99799199
49Absent radius (HP:0003974)2.98901972
50Broad alveolar ridges (HP:0000187)2.98770274
51Abnormality of glycolysis (HP:0004366)2.95189546
52Increased serum pyruvate (HP:0003542)2.93990807
53Hand muscle atrophy (HP:0009130)2.92282060
54Hepatocellular necrosis (HP:0001404)2.88460049
55Absent forearm bone (HP:0003953)2.83967407
56Aplasia involving forearm bones (HP:0009822)2.83967407
57Clumsiness (HP:0002312)2.83746693
58Acute necrotizing encephalopathy (HP:0006965)2.80887448
59Abnormality of polysaccharide metabolism (HP:0011012)2.80568903
60Abnormality of glycosaminoglycan metabolism (HP:0004371)2.80568903
61Abnormality of mucopolysaccharide metabolism (HP:0011020)2.80568903
62Decreased activity of mitochondrial respiratory chain (HP:0008972)2.78696328
63Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.78696328
64Choanal stenosis (HP:0000452)2.78500891
65Distal upper limb amyotrophy (HP:0007149)2.75397316
66Upper limb amyotrophy (HP:0009129)2.75397316
67Albinism (HP:0001022)2.74968129
68Joint stiffness (HP:0001387)2.74327507
69Hepatic necrosis (HP:0002605)2.72772341
70Squamous cell carcinoma (HP:0002860)2.66271564
71Aplasia of the musculature (HP:0100854)2.65100049
72Decreased lacrimation (HP:0000633)2.65025369
73Narrow nasal bridge (HP:0000446)2.64282206
74Hypercortisolism (HP:0001578)2.63432396
75Hamartoma (HP:0010566)2.63197643
76Mitochondrial inheritance (HP:0001427)2.60263977
77Absent thumb (HP:0009777)2.59180360
78Hypokinesia (HP:0002375)2.56923366
79Acute encephalopathy (HP:0006846)2.55924770
80Bifid uvula (HP:0000193)2.55823305
81Amelogenesis imperfecta (HP:0000705)2.49990881
82Cervical subluxation (HP:0003308)2.48994357
83Hypotelorism (HP:0000601)2.40932311
84Pancreatic islet-cell hyperplasia (HP:0004510)2.40320404
85Redundant skin (HP:0001582)2.40280821
86Volvulus (HP:0002580)2.39627515
87Polycythemia (HP:0001901)2.39239980
88Patellar aplasia (HP:0006443)2.38414337
89Abnormal gallbladder physiology (HP:0012438)2.33602062
90Cholecystitis (HP:0001082)2.33602062
91Premature graying of hair (HP:0002216)2.33418384
92Cerebral aneurysm (HP:0004944)2.30031824
93Bowing of the arm (HP:0006488)2.29353905
94Bowed forearm bones (HP:0003956)2.29353905
95Hydroureter (HP:0000072)2.26923242
96Vertebral fusion (HP:0002948)2.26556069
97Selective tooth agenesis (HP:0001592)2.26369240
98Abnormality of the labia minora (HP:0012880)2.24944904
99Popliteal pterygium (HP:0009756)2.24022904
100Broad distal phalanx of finger (HP:0009836)2.21347243
101Basal cell carcinoma (HP:0002671)2.20281450
102Abnormality of the distal phalanges of the toes (HP:0010182)2.19067021
103Aplasia/Hypoplasia of the patella (HP:0006498)2.17606694
104Increased number of teeth (HP:0011069)2.17467094
105Hypochromic anemia (HP:0001931)2.17218875
106Ankle contracture (HP:0006466)2.16346382
107Split hand (HP:0001171)2.15621349
108Spinal rigidity (HP:0003306)2.15185265
109Prolonged neonatal jaundice (HP:0006579)2.14903470
110Increased CSF lactate (HP:0002490)2.13010131
111Exertional dyspnea (HP:0002875)2.11568700
112Rough bone trabeculation (HP:0100670)2.10957002
113Hypoplasia of the capital femoral epiphysis (HP:0003090)2.10040478
114Diminished movement (HP:0002374)2.09746696
115Microvesicular hepatic steatosis (HP:0001414)2.08943196
116Hyperparathyroidism (HP:0000843)2.08669861
117Gastrointestinal atresia (HP:0002589)2.08501926
118Bulbar palsy (HP:0001283)2.08176302
119Progressive macrocephaly (HP:0004481)2.06925288
120Hypoplasia of the ulna (HP:0003022)2.06768118
121Capillary hemangiomas (HP:0005306)2.06298539
122Achilles tendon contracture (HP:0001771)2.06160151
123Abnormality of the umbilical cord (HP:0010881)2.02256922
124Testicular atrophy (HP:0000029)2.00900392
125Abnormal autonomic nervous system physiology (HP:0012332)1.98616963
126Exercise intolerance (HP:0003546)1.98220081
127Asymmetric septal hypertrophy (HP:0001670)1.98050943
128Type I transferrin isoform profile (HP:0003642)1.97705532
129Hypoplasia of the radius (HP:0002984)1.95680377
130IgA deficiency (HP:0002720)1.95078425
131Abnormality of aromatic amino acid family metabolism (HP:0004338)1.94645025
132Renal Fanconi syndrome (HP:0001994)1.94552421
133Thickened helices (HP:0000391)1.94151355
134Delayed CNS myelination (HP:0002188)1.93487938
135Retinal dysplasia (HP:0007973)1.92254418
136Lower limb hyperreflexia (HP:0002395)1.91663809
137Astrocytoma (HP:0009592)1.90843891
138Abnormality of the astrocytes (HP:0100707)1.90843891
139Spinal muscular atrophy (HP:0007269)1.90104702
140Spastic paraparesis (HP:0002313)1.89620015
141Microretrognathia (HP:0000308)1.89507278
142Adrenal hypoplasia (HP:0000835)1.89404887
143Aplasia/Hypoplasia of the sacrum (HP:0008517)1.87680211
144Abnormality of the Achilles tendon (HP:0005109)1.87257144
145Muscle fiber atrophy (HP:0100295)1.86255452
146Ragged-red muscle fibers (HP:0003200)1.85718972
147Cerebral edema (HP:0002181)1.85620690
148Emotional lability (HP:0000712)1.85579514
149Entropion (HP:0000621)1.85267005
150Generalized amyotrophy (HP:0003700)1.84108311
151Opisthotonus (HP:0002179)1.82872376
152Hyperglycinemia (HP:0002154)1.82693979
153Shoulder girdle muscle weakness (HP:0003547)1.79947887
154Lactic acidosis (HP:0003128)1.79697369
155Flattened epiphyses (HP:0003071)1.79461123
156Sparse eyelashes (HP:0000653)1.78391322
157Trismus (HP:0000211)1.77458018
158Atrophic scars (HP:0001075)1.76650417
159Occipital encephalocele (HP:0002085)1.75822041
160Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75124374
161Abnormal protein N-linked glycosylation (HP:0012347)1.75124374
162Abnormal protein glycosylation (HP:0012346)1.75124374
163Abnormal glycosylation (HP:0012345)1.75124374
164Absent epiphyses (HP:0010577)1.74120304
165Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.74120304
166Limb-girdle muscle atrophy (HP:0003797)1.74092631
167Increased serum lactate (HP:0002151)1.74065423
168Down-sloping shoulders (HP:0200021)1.72261483
169Pulmonary artery stenosis (HP:0004415)1.72189138
170Myokymia (HP:0002411)1.70937486
171Reduced subcutaneous adipose tissue (HP:0003758)1.70391050
172Spastic diplegia (HP:0001264)1.69491549
173Congenital glaucoma (HP:0001087)1.69108006
174Respiratory failure (HP:0002878)1.68902308
175Axonal loss (HP:0003447)1.68532133
176Increased intramyocellular lipid droplets (HP:0012240)1.67629659
177Abnormalities of placenta or umbilical cord (HP:0001194)1.63264781
178Nuclear cataract (HP:0100018)1.62648517
179Pterygium (HP:0001059)1.62213622
180Mitral stenosis (HP:0001718)1.62054729
181Cerebral hypomyelination (HP:0006808)1.60485702
182Insomnia (HP:0100785)1.60069674
183Hypoplastic pelvis (HP:0008839)1.60008309
184Vascular calcification (HP:0004934)1.59553756
185Hypoplastic left heart (HP:0004383)1.59343295
186Reduced antithrombin III activity (HP:0001976)1.59132349
187Mitral regurgitation (HP:0001653)1.58793973
188Abnormality of the anterior horn cell (HP:0006802)1.58339347
189Degeneration of anterior horn cells (HP:0002398)1.58339347
190Increased hepatocellular lipid droplets (HP:0006565)1.56155553
191Abnormal umbilical cord blood vessels (HP:0011403)1.56107121
192Single umbilical artery (HP:0001195)1.56107121
193Abnormality of the fetal cardiovascular system (HP:0010948)1.56107121
194Cardiovascular calcification (HP:0011915)1.53241634
195Death in infancy (HP:0001522)1.53062469
196Congenital ichthyosiform erythroderma (HP:0007431)1.51492095
197Atelectasis (HP:0100750)1.49881567

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.40614426
2MAPK155.24186630
3DDR25.17043040
4MAP3K64.21292940
5VRK24.18840632
6TESK14.17087338
7MAP3K113.58135678
8NME23.51279523
9PINK13.36682054
10LIMK13.13718096
11FGR3.12785398
12TYRO33.10127005
13MATK3.06578933
14UHMK12.74386936
15BCKDK2.65196313
16PIM22.57246694
17DAPK12.56254148
18LMTK22.25897354
19STK162.21366934
20BMX2.20306966
21YES12.15890906
22PRKD22.14431411
23MST1R2.06078565
24CSK2.04039697
25DYRK1B2.03341832
26PDGFRA1.93866632
27PAK41.91155093
28EPHB21.84824041
29ABL21.71926552
30PBK1.68669009
31SRPK11.64811167
32PRKD31.63250537
33LATS21.61492521
34AKT31.56550183
35IRAK31.56141046
36SMG11.53483654
37CDK71.48792520
38PHKG21.48072543
39PHKG11.48072543
40EPHA41.47746759
41TRPM71.38641317
42MAP3K121.35449145
43PDK21.33803352
44MET1.31407805
45NEK11.25483556
46CSNK1A1L1.25445439
47MAP2K71.25340828
48BCR1.23757352
49RPS6KL11.17640049
50RPS6KC11.17640049
51PIM11.17418915
52ERBB41.13938501
53CDC42BPA1.12694167
54CDK81.12182560
55NME11.11159966
56MYLK1.10919357
57PRPF4B1.09388189
58CDK61.04456891
59BRSK11.04309139
60GSK3A1.02056253
61RPS6KA61.00536348
62EPHB11.00311059
63CSNK1G20.95380116
64DAPK30.94219989
65MAPK110.88421062
66ERN10.87980885
67MAP3K90.86648895
68TRIM280.85245099
69CCNB10.84481453
70MOS0.83477656
71BRAF0.81989797
72LRRK20.76951718
73DYRK30.74648879
74CHEK20.73800059
75DYRK20.73091211
76MAP3K100.70240251
77CAMK2B0.67783376
78HIPK20.66852410
79TAOK20.65340457
80RAF10.64478411
81PLK10.61390171
82AKT20.59408748
83CAMK2G0.59068359
84AURKB0.58804569
85VRK10.58756954
86TRIB30.58702082
87RPS6KA10.58630601
88CSNK1G10.55487264
89EPHA20.53837026
90GRK50.53627319
91MARK10.52094137
92STK380.50388841
93MAP3K30.49145963
94PRKAA10.48995054
95EIF2AK10.48823971
96MTOR0.47274214
97ROCK20.46621814
98MINK10.43500568
99TESK20.42335399
100CAMK2A0.41379365
101SIK10.41298816
102CAMK2D0.40874126
103AURKA0.40681943
104CDK90.40660893
105CDK11A0.40304917
106BUB10.39980557
107CDK150.39947235
108EGFR0.39202166
109CSNK2A10.37406764
110CDK180.37067968
111TSSK60.36282800
112LYN0.35346121
113CDK140.33503204
114RIPK10.32915505
115CDK20.32350643
116DMPK0.32071635
117TNK20.31578316
118CSNK1A10.31472529
119MAPKAPK50.31053107
120PLK30.30618010
121PAK60.30295753
122TTK0.30262783
123NTRK20.29723813
124TAOK10.29705699
125ERBB30.29580984
126MAPK40.29035133
127MAPK30.28652430
128PTK60.28321083
129PRKG20.27864608
130RPS6KB20.27095578
131NTRK10.26644937
132PRKCZ0.25929389
133PDGFRB0.25715920
134INSR0.25551160
135MAPK10.25016364
136CSNK1G30.25006758
137MAPK100.24732668
138PAK10.24201483
139MAPKAPK20.22702863
140CSNK2A20.21142915
141PTK20.20676733
142RPS6KB10.19060270
143PRKCD0.18646365
144MAPK140.18431906
145PAK20.18070522
146PRKD10.17614085
147ARAF0.17096588
148ALK0.16702826
149ATR0.14890767
150CDK50.14417202
151SGK10.14274140
152MARK20.13906720
153ILK0.12700051
154RPS6KA30.12698782
155CDK10.12017392
156CDK190.11677367
157MAPKAPK30.10696986
158MAPK90.10139408
159PRKCI0.09951705

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.81413010
2Mismatch repair_Homo sapiens_hsa034304.72146856
3Base excision repair_Homo sapiens_hsa034104.66368822
4DNA replication_Homo sapiens_hsa030303.33197990
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.94197230
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.65736874
7Hedgehog signaling pathway_Homo sapiens_hsa043402.40522553
8Hippo signaling pathway_Homo sapiens_hsa043902.20590778
9Arginine and proline metabolism_Homo sapiens_hsa003302.19368730
10Nucleotide excision repair_Homo sapiens_hsa034202.15831721
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.14744226
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.04976187
13Circadian rhythm_Homo sapiens_hsa047102.04321870
14Notch signaling pathway_Homo sapiens_hsa043302.00080871
15Spliceosome_Homo sapiens_hsa030401.92438774
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.87680887
17mTOR signaling pathway_Homo sapiens_hsa041501.85238876
18Vibrio cholerae infection_Homo sapiens_hsa051101.76943653
19Sulfur relay system_Homo sapiens_hsa041221.71705878
20mRNA surveillance pathway_Homo sapiens_hsa030151.67130667
21Carbon metabolism_Homo sapiens_hsa012001.66294928
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.63871409
23RNA transport_Homo sapiens_hsa030131.60743459
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.53887397
25Pyrimidine metabolism_Homo sapiens_hsa002401.52556331
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52345256
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.52284395
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49818520
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48861570
30Adherens junction_Homo sapiens_hsa045201.48165146
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.47786391
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46403290
33Sulfur metabolism_Homo sapiens_hsa009201.46050013
34Basal cell carcinoma_Homo sapiens_hsa052171.45472485
35Pyruvate metabolism_Homo sapiens_hsa006201.44890842
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44501520
37Biosynthesis of amino acids_Homo sapiens_hsa012301.44201902
38Bladder cancer_Homo sapiens_hsa052191.40542865
39Homologous recombination_Homo sapiens_hsa034401.40370105
40Pentose phosphate pathway_Homo sapiens_hsa000301.39017672
41Wnt signaling pathway_Homo sapiens_hsa043101.38922008
42p53 signaling pathway_Homo sapiens_hsa041151.38907629
43Folate biosynthesis_Homo sapiens_hsa007901.38849078
44Phenylalanine metabolism_Homo sapiens_hsa003601.34929396
45Shigellosis_Homo sapiens_hsa051311.32466272
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32321078
47Protein export_Homo sapiens_hsa030601.30659260
48TGF-beta signaling pathway_Homo sapiens_hsa043501.28473198
49Fanconi anemia pathway_Homo sapiens_hsa034601.27704291
50Ribosome_Homo sapiens_hsa030101.27027056
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26874681
52N-Glycan biosynthesis_Homo sapiens_hsa005101.23108329
53Longevity regulating pathway - mammal_Homo sapiens_hsa042111.22662554
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.21492508
55Fatty acid metabolism_Homo sapiens_hsa012121.15587283
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14534636
57VEGF signaling pathway_Homo sapiens_hsa043701.12191019
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.10527239
59Gap junction_Homo sapiens_hsa045401.08031444
60Oocyte meiosis_Homo sapiens_hsa041141.03722198
61Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02811615
62Fructose and mannose metabolism_Homo sapiens_hsa000511.01236315
63Vitamin B6 metabolism_Homo sapiens_hsa007501.00373866
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99461092
65Proteasome_Homo sapiens_hsa030500.98969115
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98322825
67Tyrosine metabolism_Homo sapiens_hsa003500.95683561
68Colorectal cancer_Homo sapiens_hsa052100.91838348
69ErbB signaling pathway_Homo sapiens_hsa040120.89437056
70Peroxisome_Homo sapiens_hsa041460.88506523
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87423195
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.86140658
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85902597
74Metabolic pathways_Homo sapiens_hsa011000.85607615
75Tight junction_Homo sapiens_hsa045300.83548199
76Cell cycle_Homo sapiens_hsa041100.82276323
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82187681
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77597853
79beta-Alanine metabolism_Homo sapiens_hsa004100.76418506
80Dorso-ventral axis formation_Homo sapiens_hsa043200.73483486
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72301051
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72266716
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.71887209
84Choline metabolism in cancer_Homo sapiens_hsa052310.71546663
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70921283
86Other glycan degradation_Homo sapiens_hsa005110.70502433
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65550179
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63778154
89Oxidative phosphorylation_Homo sapiens_hsa001900.62220368
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60824431
91Propanoate metabolism_Homo sapiens_hsa006400.58899568
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.57350759
93Parkinsons disease_Homo sapiens_hsa050120.56660190
94Purine metabolism_Homo sapiens_hsa002300.56343200
95Primary immunodeficiency_Homo sapiens_hsa053400.55914012
96MicroRNAs in cancer_Homo sapiens_hsa052060.54696513
97Fatty acid elongation_Homo sapiens_hsa000620.53187931
98Huntingtons disease_Homo sapiens_hsa050160.51906501
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.50500911
100Fatty acid degradation_Homo sapiens_hsa000710.49205135
101Acute myeloid leukemia_Homo sapiens_hsa052210.47714283
102Viral myocarditis_Homo sapiens_hsa054160.47365505
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.45647602
104Chronic myeloid leukemia_Homo sapiens_hsa052200.45617923
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45451055
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45080598
107MAPK signaling pathway_Homo sapiens_hsa040100.44434683
108Cardiac muscle contraction_Homo sapiens_hsa042600.44243255
109ECM-receptor interaction_Homo sapiens_hsa045120.43156249
110Steroid biosynthesis_Homo sapiens_hsa001000.42882005
111Insulin signaling pathway_Homo sapiens_hsa049100.42880392
112Lysosome_Homo sapiens_hsa041420.42849488
113Prion diseases_Homo sapiens_hsa050200.42757484
114RNA polymerase_Homo sapiens_hsa030200.42555745
115Thyroid cancer_Homo sapiens_hsa052160.41965565
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41559327
117Glutathione metabolism_Homo sapiens_hsa004800.40973455
118Galactose metabolism_Homo sapiens_hsa000520.40934879
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40440185
120Endocytosis_Homo sapiens_hsa041440.40133892
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38423426
122Chemical carcinogenesis_Homo sapiens_hsa052040.38399445
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35969781
124GnRH signaling pathway_Homo sapiens_hsa049120.35637522
125Legionellosis_Homo sapiens_hsa051340.35513121
126Synaptic vesicle cycle_Homo sapiens_hsa047210.35366328
127Endometrial cancer_Homo sapiens_hsa052130.33819922
128AMPK signaling pathway_Homo sapiens_hsa041520.33080029
129Axon guidance_Homo sapiens_hsa043600.32594770
130PPAR signaling pathway_Homo sapiens_hsa033200.32337645
131Proteoglycans in cancer_Homo sapiens_hsa052050.32172075
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31266950
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31124649
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30608855
135Sphingolipid metabolism_Homo sapiens_hsa006000.30401050
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30029039
137Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.28647340
138Viral carcinogenesis_Homo sapiens_hsa052030.28451695
139Estrogen signaling pathway_Homo sapiens_hsa049150.27119264
140Epstein-Barr virus infection_Homo sapiens_hsa051690.24926702
141Lysine degradation_Homo sapiens_hsa003100.24780764
142Small cell lung cancer_Homo sapiens_hsa052220.24389890
143Long-term depression_Homo sapiens_hsa047300.23533410
144GABAergic synapse_Homo sapiens_hsa047270.23111708
145Mineral absorption_Homo sapiens_hsa049780.22476511
146Amphetamine addiction_Homo sapiens_hsa050310.22402765
147Pathways in cancer_Homo sapiens_hsa052000.21939120
148Alzheimers disease_Homo sapiens_hsa050100.21692658
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.19650895
150Focal adhesion_Homo sapiens_hsa045100.19567064
151Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18244177
152Collecting duct acid secretion_Homo sapiens_hsa049660.17383270
153Arginine biosynthesis_Homo sapiens_hsa002200.17012672
154Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16574862

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