MANEA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by several ER glycosidases and by an endomannosidase (E.C. 3.2.1.130), such as MANEA, in the Golgi. MANEA catalyzes the release of mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that links them to high-mannose glycans (Hamilton et al., 2005 [PubMed 15677381]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of smell (GO:0007608)6.97066804
2iron ion import (GO:0097286)5.26980513
3nuclear pore organization (GO:0006999)4.84830819
4axon ensheathment in central nervous system (GO:0032291)4.69889155
5central nervous system myelination (GO:0022010)4.69889155
6UDP-N-acetylglucosamine metabolic process (GO:0006047)4.69772372
7nuclear pore complex assembly (GO:0051292)4.43170267
8biotin metabolic process (GO:0006768)4.42132713
9replicative senescence (GO:0090399)4.33017178
10cellular glucuronidation (GO:0052695)4.30817836
11negative regulation of glycogen biosynthetic process (GO:0045719)4.21341630
12negative regulation of neurotransmitter secretion (GO:0046929)4.16255629
13glucuronate metabolic process (GO:0019585)4.11732453
14uronic acid metabolic process (GO:0006063)4.11732453
15negative regulation of neurotransmitter transport (GO:0051589)3.90071809
16neuron cell-cell adhesion (GO:0007158)3.87324607
17alpha-linolenic acid metabolic process (GO:0036109)3.76074584
18sensory perception of chemical stimulus (GO:0007606)3.75413700
19mitotic sister chromatid cohesion (GO:0007064)3.72471616
20cerebral cortex radially oriented cell migration (GO:0021799)3.64915353
21COPII vesicle coating (GO:0048208)3.64691104
22dendrite morphogenesis (GO:0048813)3.64688677
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.59014856
24negative regulation of JUN kinase activity (GO:0043508)3.56605655
25branched-chain amino acid catabolic process (GO:0009083)3.53875755
26axonal fasciculation (GO:0007413)3.53814589
27non-recombinational repair (GO:0000726)3.52152644
28double-strand break repair via nonhomologous end joining (GO:0006303)3.52152644
29embryonic foregut morphogenesis (GO:0048617)3.47617160
30anterior/posterior axis specification, embryo (GO:0008595)3.41379752
31neuron recognition (GO:0008038)3.39946456
32short-chain fatty acid metabolic process (GO:0046459)3.38584005
33presynaptic membrane assembly (GO:0097105)3.34403262
34negative regulation of synaptic transmission, GABAergic (GO:0032229)3.34087439
35regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.29613424
36negative regulation of glycogen metabolic process (GO:0070874)3.27094549
37beta-amyloid metabolic process (GO:0050435)3.24934479
38response to pheromone (GO:0019236)3.21319114
39folic acid-containing compound metabolic process (GO:0006760)3.16656126
40DNA ligation (GO:0006266)3.14774899
41somatic hypermutation of immunoglobulin genes (GO:0016446)3.12641616
42somatic diversification of immune receptors via somatic mutation (GO:0002566)3.12641616
43protein K6-linked ubiquitination (GO:0085020)3.12101504
44regulation of DNA endoreduplication (GO:0032875)3.10830935
45nerve growth factor signaling pathway (GO:0038180)3.04361287
46pore complex assembly (GO:0046931)3.02351422
47presynaptic membrane organization (GO:0097090)3.01131414
48regulation of synaptic vesicle exocytosis (GO:2000300)2.98100612
49regulation of acyl-CoA biosynthetic process (GO:0050812)2.97178250
50bile acid biosynthetic process (GO:0006699)2.96889566
51resolution of meiotic recombination intermediates (GO:0000712)2.94819985
52protein localization to kinetochore (GO:0034501)2.92633579
53L-amino acid import (GO:0043092)2.89962904
54regulation of coenzyme metabolic process (GO:0051196)2.88330136
55regulation of cofactor metabolic process (GO:0051193)2.88330136
56metaphase plate congression (GO:0051310)2.87638712
57substrate-independent telencephalic tangential migration (GO:0021826)2.86806729
58substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.86806729
59N-acetylneuraminate metabolic process (GO:0006054)2.85614960
60glutamate secretion (GO:0014047)2.83120785
61myelination (GO:0042552)2.80742327
62regulation of sulfur metabolic process (GO:0042762)2.80601677
63fatty acid elongation (GO:0030497)2.78197254
64central nervous system projection neuron axonogenesis (GO:0021952)2.78189718
65mitotic metaphase plate congression (GO:0007080)2.77648379
66protein localization to chromosome, centromeric region (GO:0071459)2.77175885
67pteridine-containing compound metabolic process (GO:0042558)2.76930176
68transmission of nerve impulse (GO:0019226)2.76545925
69gamma-aminobutyric acid transport (GO:0015812)2.75634043
70zinc ion transmembrane transport (GO:0071577)2.74462018
71attachment of spindle microtubules to kinetochore (GO:0008608)2.73665541
72vocalization behavior (GO:0071625)2.73317413
73synaptic vesicle exocytosis (GO:0016079)2.73204179
74long-chain fatty acid biosynthetic process (GO:0042759)2.73010615
75CENP-A containing nucleosome assembly (GO:0034080)2.72798549
76dendritic spine morphogenesis (GO:0060997)2.72191729
77nucleotide-sugar metabolic process (GO:0009225)2.70892331
78ensheathment of neurons (GO:0007272)2.70388313
79axon ensheathment (GO:0008366)2.70388313
80mRNA cleavage (GO:0006379)2.69988037
81pyrimidine nucleobase catabolic process (GO:0006208)2.69967965
82nucleotide-sugar biosynthetic process (GO:0009226)2.69030709
83magnesium ion transport (GO:0015693)2.68677532
84branched-chain amino acid metabolic process (GO:0009081)2.68141959
85somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.67187129
86somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.67187129
87isotype switching (GO:0045190)2.67187129
88chondrocyte development (GO:0002063)2.66107796
89regulation of helicase activity (GO:0051095)2.65945888
90response to X-ray (GO:0010165)2.64938401
91COPI coating of Golgi vesicle (GO:0048205)2.64313023
92Golgi transport vesicle coating (GO:0048200)2.64313023
93negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.63537412
94tricarboxylic acid cycle (GO:0006099)2.62516878
95S-adenosylmethionine metabolic process (GO:0046500)2.62322239
96protein localization to cilium (GO:0061512)2.62273385
97ionotropic glutamate receptor signaling pathway (GO:0035235)2.61835466
98membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.61716950
99sister chromatid segregation (GO:0000819)2.61109055
100chromatin remodeling at centromere (GO:0031055)2.60800857
101branching involved in prostate gland morphogenesis (GO:0060442)2.60548788
102response to auditory stimulus (GO:0010996)2.60333382
103spindle checkpoint (GO:0031577)2.60202937
104negative regulation of metanephros development (GO:0072217)2.59939269
105cerebral cortex cell migration (GO:0021795)2.59517950
106somatic recombination of immunoglobulin gene segments (GO:0016447)2.59069374
107regulation of cardioblast differentiation (GO:0051890)2.58877015
108DNA double-strand break processing (GO:0000729)2.58394940
109negative regulation of activin receptor signaling pathway (GO:0032926)2.58065447
110L-serine metabolic process (GO:0006563)2.57172057
111zinc ion transport (GO:0006829)2.56621762
112layer formation in cerebral cortex (GO:0021819)2.55543964
113purine nucleobase biosynthetic process (GO:0009113)2.55293272
114somite rostral/caudal axis specification (GO:0032525)2.55007377
115synapsis (GO:0007129)2.54843457
116negative regulation of synaptic transmission (GO:0050805)2.54471534
117establishment of chromosome localization (GO:0051303)2.54281154
118DNA replication-dependent nucleosome assembly (GO:0006335)2.53965228
119DNA replication-dependent nucleosome organization (GO:0034723)2.53965228
120prenylation (GO:0097354)2.53947931
121protein prenylation (GO:0018342)2.53947931
122signal transduction involved in regulation of gene expression (GO:0023019)2.53445729
123embryonic axis specification (GO:0000578)2.52762757
124folic acid-containing compound biosynthetic process (GO:0009396)2.52386294
125long-term synaptic potentiation (GO:0060291)2.52342047
126mitotic spindle checkpoint (GO:0071174)2.51888323
127fusion of sperm to egg plasma membrane (GO:0007342)2.51506017
128prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.50737255
129behavioral response to cocaine (GO:0048148)2.50647579
130acyl-CoA metabolic process (GO:0006637)2.50426065
131thioester metabolic process (GO:0035383)2.50426065
132regulation of synapse structural plasticity (GO:0051823)2.50396194
133negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.50249037
134glutamate receptor signaling pathway (GO:0007215)2.49547661
135signal peptide processing (GO:0006465)2.46016172
136anterior/posterior axis specification (GO:0009948)2.45404870
137negative regulation of glucose import (GO:0046325)2.44712652
138clathrin coat assembly (GO:0048268)2.44681820
139L-phenylalanine catabolic process (GO:0006559)2.44673077
140erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.44673077
141auditory receptor cell differentiation (GO:0042491)2.44636924
142response to nitrosative stress (GO:0051409)2.44484086
143L-serine transport (GO:0015825)2.42769482
144somatic diversification of immunoglobulins (GO:0016445)2.42658363
145mitotic sister chromatid segregation (GO:0000070)2.42309307
146phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.41739500
147central nervous system neuron axonogenesis (GO:0021955)2.41731443
148negative regulation of astrocyte differentiation (GO:0048712)2.41624585
149gamma-aminobutyric acid signaling pathway (GO:0007214)2.39686723
150response to methylmercury (GO:0051597)2.39612730
151regulation of beta-amyloid formation (GO:1902003)2.37790659
152forebrain cell migration (GO:0021885)2.37751498
153regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.37373785
154positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.36604069
155glycerophospholipid catabolic process (GO:0046475)2.36290211
156amino acid import (GO:0043090)2.35772503
157photoreceptor cell differentiation (GO:0046530)2.35168856
158eye photoreceptor cell differentiation (GO:0001754)2.35168856
159neuronal action potential propagation (GO:0019227)2.34670154
160negative regulation of axon extension (GO:0030517)2.34196079
161locomotory exploration behavior (GO:0035641)2.33983909
162import into cell (GO:0098657)2.32700471
163positive regulation of action potential (GO:0045760)2.32175501
164synaptic vesicle maturation (GO:0016188)2.31893984
165regulation of axon extension involved in axon guidance (GO:0048841)2.31634189
166L-fucose catabolic process (GO:0042355)2.31105292
167fucose catabolic process (GO:0019317)2.31105292
168L-fucose metabolic process (GO:0042354)2.31105292
169synapse assembly (GO:0007416)2.30345555
170regulation of synaptic vesicle transport (GO:1902803)2.30045145
171activation of protein kinase A activity (GO:0034199)2.28771138
172regulation of short-term neuronal synaptic plasticity (GO:0048172)2.28308482
173neuron remodeling (GO:0016322)2.27961640
174negative regulation of glucose transport (GO:0010829)2.27599028
175Rap protein signal transduction (GO:0032486)2.26978712
176auditory behavior (GO:0031223)2.25574146
177telencephalon cell migration (GO:0022029)2.24610803
178cellular potassium ion homeostasis (GO:0030007)2.24176316
179regulation of synaptic transmission, glutamatergic (GO:0051966)2.23567000
180negative regulation of axon extension involved in axon guidance (GO:0048843)2.22650182
181regulation of axon guidance (GO:1902667)2.22211893
182regulation of long-term neuronal synaptic plasticity (GO:0048169)2.20957051
183neuron-neuron synaptic transmission (GO:0007270)2.20362379
184detection of calcium ion (GO:0005513)2.19511878
185long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.18557350
186synaptic transmission, glutamatergic (GO:0035249)2.18211265
187mechanosensory behavior (GO:0007638)2.18005800
188regulation of glutamate receptor signaling pathway (GO:1900449)2.17365515
189establishment of nucleus localization (GO:0040023)2.15868443
190cyclic nucleotide catabolic process (GO:0009214)2.14143680
191negative regulation of axonogenesis (GO:0050771)2.13281420
192adult walking behavior (GO:0007628)2.12892452
193vascular smooth muscle contraction (GO:0014829)2.10766658
194axonogenesis (GO:0007409)2.10275388
195negative regulation of axon guidance (GO:1902668)2.09721908
196regulation of dendritic spine development (GO:0060998)2.08929851
197regulation of amyloid precursor protein catabolic process (GO:1902991)2.08306883

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.18894435
2E2F7_22180533_ChIP-Seq_HELA_Human4.10265095
3GBX2_23144817_ChIP-Seq_PC3_Human3.73672051
4AR_21909140_ChIP-Seq_LNCAP_Human3.45464674
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.41276179
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.82517239
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.67512877
8TAF15_26573619_Chip-Seq_HEK293_Human2.65248934
9PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.53675107
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.39032469
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.37708635
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.36942108
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31977042
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.29344900
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29272241
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28958670
17* EWS_26573619_Chip-Seq_HEK293_Human2.28143909
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20657503
19VDR_22108803_ChIP-Seq_LS180_Human2.15569510
20* ELK1_19687146_ChIP-ChIP_HELA_Human2.14197417
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.11545401
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.05706838
23EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01636874
24RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01636874
25AR_21572438_ChIP-Seq_LNCaP_Human1.94584530
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.93726836
27* PIAS1_25552417_ChIP-Seq_VCAP_Human1.92328040
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91798451
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.91190597
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.88658632
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.88616089
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.88170367
33* P300_19829295_ChIP-Seq_ESCs_Human1.87554072
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.87370803
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.83422548
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83240120
37OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.81301964
38* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81085544
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78705557
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.78147132
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78058303
42DROSHA_22980978_ChIP-Seq_HELA_Human1.77361158
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.77115108
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76996472
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.75181123
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67718262
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67709227
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66515464
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64132652
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63890225
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.60798972
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59340695
53SMAD4_21799915_ChIP-Seq_A2780_Human1.55881398
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55800320
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55663947
56* SMAD3_21741376_ChIP-Seq_EPCs_Human1.51421301
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49275904
58GABP_17652178_ChIP-ChIP_JURKAT_Human1.49123676
59RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.48231037
60FUS_26573619_Chip-Seq_HEK293_Human1.47674993
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.47399096
62TP53_18474530_ChIP-ChIP_U2OS_Human1.46299232
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45962447
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.45787461
65ER_23166858_ChIP-Seq_MCF-7_Human1.45313377
66* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44973668
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.44885708
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.43260867
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42279342
70STAT3_23295773_ChIP-Seq_U87_Human1.40580495
71* CBX2_27304074_Chip-Seq_ESCs_Mouse1.40409808
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40299259
73CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38798353
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.37402970
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37157220
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36960039
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36500173
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36500173
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35375977
80* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34631731
81AHR_22903824_ChIP-Seq_MCF-7_Human1.34098684
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33717394
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.33211796
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32895341
85VDR_23849224_ChIP-Seq_CD4+_Human1.32565403
86SALL4_18804426_ChIP-ChIP_XEN_Mouse1.32175707
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31729736
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31561662
89HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30228067
90FOXM1_26456572_ChIP-Seq_MCF-7_Human1.30035252
91FOXM1_23109430_ChIP-Seq_U2OS_Human1.29202101
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29068002
93EST1_17652178_ChIP-ChIP_JURKAT_Human1.28111544
94EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27794123
95FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.26696900
96CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.26197759
97KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.26055446
98KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.26055446
99KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.26055446
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25764234
101CRX_20693478_ChIP-Seq_RETINA_Mouse1.25746859
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25334684
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25334684
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.24380646
105MYC_18555785_ChIP-Seq_MESCs_Mouse1.23792938
106* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23367739
107SOX2_21211035_ChIP-Seq_LN229_Gbm1.23035943
108FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.22663249
109CMYC_18555785_Chip-Seq_ESCs_Mouse1.21842992
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.21438112
111P53_22387025_ChIP-Seq_ESCs_Mouse1.21417487
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21239051
113RUNX2_22187159_ChIP-Seq_PCA_Human1.19739214
114AR_25329375_ChIP-Seq_VCAP_Human1.19241014
115TCF4_23295773_ChIP-Seq_U87_Human1.17929976
116REST_21632747_ChIP-Seq_MESCs_Mouse1.17024401
117CDX2_22108803_ChIP-Seq_LS180_Human1.16745032
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15770912
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15478980
120BCAT_22108803_ChIP-Seq_LS180_Human1.15472214
121SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15361972
122CHD1_26751641_Chip-Seq_LNCaP_Human1.14571008
123TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13856487
124EOMES_21245162_ChIP-Seq_HESCs_Human1.12706110
125NFE2_27457419_Chip-Seq_LIVER_Mouse1.12642177
126TP53_16413492_ChIP-PET_HCT116_Human1.11195956
127AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.10550606
128E2F1_21310950_ChIP-Seq_MCF-7_Human1.10208873
129FLI1_27457419_Chip-Seq_LIVER_Mouse1.10113128
130ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10069193
131RNF2_27304074_Chip-Seq_NSC_Mouse1.09893754
132JUN_21703547_ChIP-Seq_K562_Human1.09841811
133RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09064848
134HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08545010
135CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08508625
136EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08462557
137MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06806040
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06459688
139LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06370870
140FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.06253075
141EP300_21415370_ChIP-Seq_HL-1_Mouse1.06243715
142PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05686145
143RXR_22108803_ChIP-Seq_LS180_Human1.04104760
144SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03076346
145ZNF274_21170338_ChIP-Seq_K562_Hela1.02641027
146SOX17_20123909_ChIP-Seq_XEN_Mouse1.02206822
147FOXP3_21729870_ChIP-Seq_TREG_Human1.02146897
148MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01995790
149SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01835266
150IGF1R_20145208_ChIP-Seq_DFB_Human1.01135610
151RARB_27405468_Chip-Seq_BRAIN_Mouse1.00720917
152PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99492975
153P300_18555785_Chip-Seq_ESCs_Mouse0.99060186
154OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98511455
155DCP1A_22483619_ChIP-Seq_HELA_Human0.97986476
156HTT_18923047_ChIP-ChIP_STHdh_Human0.94509355
157* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93923130
158OCT4_18555785_Chip-Seq_ESCs_Mouse0.93484669
159NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93148791
160NMYC_18555785_Chip-Seq_ESCs_Mouse0.93066923
161SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92830098

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction7.16973725
2MP0003890_abnormal_embryonic-extraembry4.62027276
3MP0003880_abnormal_central_pattern4.22858707
4MP0008057_abnormal_DNA_replication4.17341509
5MP0003123_paternal_imprinting3.88139495
6MP0002009_preneoplasia3.47445796
7MP0004859_abnormal_synaptic_plasticity3.19319760
8MP0010094_abnormal_chromosome_stability2.71281006
9MP0000920_abnormal_myelination2.69201944
10MP0003635_abnormal_synaptic_transmissio2.60322216
11MP0001486_abnormal_startle_reflex2.59015131
12MP0003693_abnormal_embryo_hatching2.54848123
13MP0004233_abnormal_muscle_weight2.47494281
14MP0005085_abnormal_gallbladder_physiolo2.43684464
15MP0008058_abnormal_DNA_repair2.34539411
16MP0000778_abnormal_nervous_system2.25084183
17MP0009745_abnormal_behavioral_response2.24272367
18MP0002064_seizures2.22548698
19MP0002063_abnormal_learning/memory/cond2.21164898
20MP0004270_analgesia2.14591475
21MP0002166_altered_tumor_susceptibility2.12283416
22MP0002272_abnormal_nervous_system2.07515085
23MP0009046_muscle_twitch2.03884163
24MP0005365_abnormal_bile_salt2.02480382
25MP0004957_abnormal_blastocyst_morpholog2.00077937
26MP0001485_abnormal_pinna_reflex1.98071288
27MP0005171_absent_coat_pigmentation1.97302187
28MP0005645_abnormal_hypothalamus_physiol1.95803080
29MP0003690_abnormal_glial_cell1.93886624
30MP0002572_abnormal_emotion/affect_behav1.92563157
31MP0003329_amyloid_beta_deposits1.89742396
32MP0004742_abnormal_vestibular_system1.89092076
33MP0000569_abnormal_digit_pigmentation1.77248680
34MP0002184_abnormal_innervation1.76241579
35MP0002734_abnormal_mechanical_nocicepti1.69705780
36MP0005623_abnormal_meninges_morphology1.69388442
37MP0008007_abnormal_cellular_replicative1.64859026
38MP0003011_delayed_dark_adaptation1.64778897
39MP0003121_genomic_imprinting1.60675758
40MP0003634_abnormal_glial_cell1.60124485
41MP0001188_hyperpigmentation1.59760977
42MP0002067_abnormal_sensory_capabilities1.59091214
43MP0002557_abnormal_social/conspecific_i1.58848964
44MP0003077_abnormal_cell_cycle1.57834298
45MP0003633_abnormal_nervous_system1.56364318
46MP0003941_abnormal_skin_development1.54760636
47MP0002006_tumorigenesis1.54168876
48MP0006276_abnormal_autonomic_nervous1.49911404
49MP0003806_abnormal_nucleotide_metabolis1.48975630
50MP0003868_abnormal_feces_composition1.47050089
51MP0003111_abnormal_nucleus_morphology1.45080911
52MP0001177_atelectasis1.42631035
53MP0010368_abnormal_lymphatic_system1.42543055
54MP0003631_nervous_system_phenotype1.41814808
55MP0008438_abnormal_cutaneous_collagen1.41085544
56MP0002139_abnormal_hepatobiliary_system1.40277908
57MP0004885_abnormal_endolymph1.38952376
58MP0001440_abnormal_grooming_behavior1.37547283
59MP0005408_hypopigmentation1.36999183
60MP0010307_abnormal_tumor_latency1.36802567
61MP0003136_yellow_coat_color1.36007783
62MP0005220_abnormal_exocrine_pancreas1.35383633
63MP0008569_lethality_at_weaning1.35325032
64MP0009780_abnormal_chondrocyte_physiolo1.34633643
65MP0001672_abnormal_embryogenesis/_devel1.34483441
66MP0005380_embryogenesis_phenotype1.34483441
67MP0001905_abnormal_dopamine_level1.34329441
68MP0005647_abnormal_sex_gland1.34107285
69MP0001968_abnormal_touch/_nociception1.32951674
70MP0001529_abnormal_vocalization1.32470273
71MP0003632_abnormal_nervous_system1.32155899
72MP0008877_abnormal_DNA_methylation1.31874464
73MP0005379_endocrine/exocrine_gland_phen1.31103343
74MP0002882_abnormal_neuron_morphology1.31036517
75MP0001299_abnormal_eye_distance/1.30766939
76MP0010352_gastrointestinal_tract_polyps1.30525019
77MP0004264_abnormal_extraembryonic_tissu1.28886764
78MP0004134_abnormal_chest_morphology1.28547623
79MP0003943_abnormal_hepatobiliary_system1.27624502
80MP0005409_darkened_coat_color1.27049027
81MP0001666_abnormal_nutrient_absorption1.25710767
82MP0003718_maternal_effect1.25461250
83MP0001730_embryonic_growth_arrest1.25247556
84MP0000604_amyloidosis1.24978692
85MP0003656_abnormal_erythrocyte_physiolo1.24328466
86MP0001919_abnormal_reproductive_system1.24262734
87MP0004272_abnormal_basement_membrane1.23867260
88MP0001501_abnormal_sleep_pattern1.23769506
89MP0002084_abnormal_developmental_patter1.23241103
90MP0003984_embryonic_growth_retardation1.23132406
91MP0003786_premature_aging1.22083101
92MP0001764_abnormal_homeostasis1.21767851
93MP0002088_abnormal_embryonic_growth/wei1.20346287
94MP0008932_abnormal_embryonic_tissue1.20169191
95MP0006072_abnormal_retinal_apoptosis1.19964058
96MP0002295_abnormal_pulmonary_circulatio1.19158350
97MP0008995_early_reproductive_senescence1.17869029
98MP0001661_extended_life_span1.16669227
99MP0004142_abnormal_muscle_tone1.16184822
100MP0002086_abnormal_extraembryonic_tissu1.14472150
101MP0010234_abnormal_vibrissa_follicle1.12918620
102MP0003315_abnormal_perineum_morphology1.12388683
103MP0005646_abnormal_pituitary_gland1.12106021
104MP0003950_abnormal_plasma_membrane1.11932711
105MP0002152_abnormal_brain_morphology1.11789163
106MP0001970_abnormal_pain_threshold1.09539636
107MP0002736_abnormal_nociception_after1.09348896
108MP0006054_spinal_hemorrhage1.08733249
109MP0004811_abnormal_neuron_physiology1.08327709
110MP0002396_abnormal_hematopoietic_system1.08272673
111MP0002066_abnormal_motor_capabilities/c1.08153778
112MP0005253_abnormal_eye_physiology1.06666459
113MP0002229_neurodegeneration1.06506250
114MP0003300_gastrointestinal_ulcer1.05429564
115MP0002160_abnormal_reproductive_system1.05183770
116MP0001697_abnormal_embryo_size1.05143360
117MP0000537_abnormal_urethra_morphology1.04357616
118MP0005423_abnormal_somatic_nervous1.04258871
119MP0003283_abnormal_digestive_organ1.04158591
120MP0002735_abnormal_chemical_nociception0.99842689
121MP0005332_abnormal_amino_acid0.99536428
122MP0000598_abnormal_liver_morphology0.98682391
123MP0002752_abnormal_somatic_nervous0.98677878
124MP0005389_reproductive_system_phenotype0.98622501
125MP0000631_abnormal_neuroendocrine_gland0.98255515
126MP0003936_abnormal_reproductive_system0.98008446
127MP0002938_white_spotting0.97796641
128MP0000955_abnormal_spinal_cord0.97523879
129MP0005503_abnormal_tendon_morphology0.97348069
130MP0010678_abnormal_skin_adnexa0.97285237
131MP0004924_abnormal_behavior0.97226795
132MP0005386_behavior/neurological_phenoty0.97226795
133MP0002877_abnormal_melanocyte_morpholog0.94486342
134MP0002733_abnormal_thermal_nociception0.93150845
135MP0003045_fibrosis0.92566444
136MP0004197_abnormal_fetal_growth/weight/0.91133334
137MP0009697_abnormal_copulation0.90881340
138MP0001963_abnormal_hearing_physiology0.90451403
139MP0000372_irregular_coat_pigmentation0.90148989
140MP0005395_other_phenotype0.89992605
141MP0002163_abnormal_gland_morphology0.89849805
142MP0005084_abnormal_gallbladder_morpholo0.88012183
143MP0005187_abnormal_penis_morphology0.87641558
144MP0005551_abnormal_eye_electrophysiolog0.87626211
145MP0000639_abnormal_adrenal_gland0.86956518
146MP0004147_increased_porphyrin_level0.86398291
147MP0008789_abnormal_olfactory_epithelium0.85834409
148MP0003937_abnormal_limbs/digits/tail_de0.85804470
149MP0005499_abnormal_olfactory_system0.85286044
150MP0005394_taste/olfaction_phenotype0.85286044
151MP0000566_synostosis0.83135407
152MP0002085_abnormal_embryonic_tissue0.82018541
153MP0009384_cardiac_valve_regurgitation0.81005451
154MP0000350_abnormal_cell_proliferation0.79360289
155MP0000428_abnormal_craniofacial_morphol0.79172926
156MP0003195_calcinosis0.78916387
157MP0003567_abnormal_fetal_cardiomyocyte0.78149822
158MP0000383_abnormal_hair_follicle0.77622925
159MP0005388_respiratory_system_phenotype0.77467028
160MP0002133_abnormal_respiratory_system0.77467028
161MP0000013_abnormal_adipose_tissue0.77212409
162MP0002102_abnormal_ear_morphology0.76905073
163MP0003221_abnormal_cardiomyocyte_apopto0.75853282
164MP0005058_abnormal_lysosome_morphology0.75714424
165MP0001879_abnormal_lymphatic_vessel0.74996517
166MP0005595_abnormal_vascular_smooth0.74840216
167MP0004858_abnormal_nervous_system0.73853901
168MP0000627_abnormal_mammary_gland0.73816341
169MP0002282_abnormal_trachea_morphology0.73761965
170MP0001119_abnormal_female_reproductive0.71900849
171MP0003252_abnormal_bile_duct0.71894462
172MP0000026_abnormal_inner_ear0.71769713
173MP0001881_abnormal_mammary_gland0.71102312
174MP0001191_abnormal_skin_condition0.70664817
175MP0006138_congestive_heart_failure0.70463927
176MP0005410_abnormal_fertilization0.70335804
177MP0005367_renal/urinary_system_phenotyp0.67543301
178MP0000516_abnormal_urinary_system0.67543301
179MP0002090_abnormal_vision0.65822915
180MP0001958_emphysema0.62354764
181MP0005195_abnormal_posterior_eye0.61901563
182MP0008875_abnormal_xenobiotic_pharmacok0.61109689
183MP0005360_urolithiasis0.60288786

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.47274868
2Retinal dysplasia (HP:0007973)4.95808816
3Termporal pattern (HP:0011008)3.92745185
4Insidious onset (HP:0003587)3.92745185
5Gonadal dysgenesis (HP:0000133)3.78741277
6Focal seizures (HP:0007359)3.78309254
7Chromsome breakage (HP:0040012)3.74712872
8Neurofibrillary tangles (HP:0002185)3.66387662
9Gonadotropin excess (HP:0000837)3.49162369
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.45927331
11Degeneration of the lateral corticospinal tracts (HP:0002314)3.44863860
12Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.44863860
13Absence seizures (HP:0002121)3.42378360
14Reduced antithrombin III activity (HP:0001976)3.21340683
15Atonic seizures (HP:0010819)3.20279911
16Abnormality of chromosome stability (HP:0003220)3.14048579
17Febrile seizures (HP:0002373)3.13588030
18Intrahepatic cholestasis (HP:0001406)3.12400967
19Abnormal biliary tract morphology (HP:0012440)3.02794700
20Renal cortical cysts (HP:0000803)3.02500879
21Cerebral inclusion bodies (HP:0100314)2.95191228
22Prostate neoplasm (HP:0100787)2.93445637
23Dialeptic seizures (HP:0011146)2.92419958
24Hyperventilation (HP:0002883)2.92010075
25Bifid tongue (HP:0010297)2.90357314
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.89242345
27Abnormal umbilical cord blood vessels (HP:0011403)2.84139240
28Single umbilical artery (HP:0001195)2.84139240
29Abnormality of the fetal cardiovascular system (HP:0010948)2.84139240
30Limb hypertonia (HP:0002509)2.83863687
31Proximal tubulopathy (HP:0000114)2.79837428
32Testicular neoplasm (HP:0010788)2.79272811
33Hypoglycemic coma (HP:0001325)2.78072530
34Embryonal renal neoplasm (HP:0011794)2.77054609
35Nephroblastoma (Wilms tumor) (HP:0002667)2.74881618
36Akinesia (HP:0002304)2.72798981
37Abnormality of the corticospinal tract (HP:0002492)2.71258697
38Meckel diverticulum (HP:0002245)2.67194419
39Xerostomia (HP:0000217)2.65714393
40Supranuclear gaze palsy (HP:0000605)2.65659161
41Generalized tonic-clonic seizures (HP:0002069)2.60408337
42Hyperglycinemia (HP:0002154)2.57872443
43Methylmalonic acidemia (HP:0002912)2.53390134
44Limb dystonia (HP:0002451)2.52536156
45Epileptic encephalopathy (HP:0200134)2.50635560
46Abnormality of the ileum (HP:0001549)2.48971199
47Agammaglobulinemia (HP:0004432)2.48531390
48Sensory axonal neuropathy (HP:0003390)2.48265655
49Rhabdomyosarcoma (HP:0002859)2.48034524
50Abnormal ventriculo-arterial connection (HP:0011563)2.47705528
51Transposition of the great arteries (HP:0001669)2.47705528
52Abnormal connection of the cardiac segments (HP:0011545)2.47705528
53Diplopia (HP:0000651)2.46837483
54Abnormality of binocular vision (HP:0011514)2.46837483
55Myelomeningocele (HP:0002475)2.45777069
56Abnormality of the preputium (HP:0100587)2.43688690
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.41920010
58Parakeratosis (HP:0001036)2.41110774
59Blue irides (HP:0000635)2.40720018
60Biliary tract neoplasm (HP:0100574)2.40095270
61Ovarian neoplasm (HP:0100615)2.38905400
62Aqueductal stenosis (HP:0002410)2.38565723
63Megalencephaly (HP:0001355)2.38391394
64Absent eyebrow (HP:0002223)2.35619950
65Abolished electroretinogram (ERG) (HP:0000550)2.35228825
66Chronic hepatic failure (HP:0100626)2.35136817
67Action tremor (HP:0002345)2.34748348
68Abnormality of methionine metabolism (HP:0010901)2.31632896
69Abnormality of salivation (HP:0100755)2.30519550
70Widely spaced teeth (HP:0000687)2.28319848
71Abnormal lung lobation (HP:0002101)2.28121417
72Medulloblastoma (HP:0002885)2.27743907
73Visual hallucinations (HP:0002367)2.27738606
74Hypobetalipoproteinemia (HP:0003563)2.27581688
75Abnormality of serine family amino acid metabolism (HP:0010894)2.25907470
76Abnormality of glycine metabolism (HP:0010895)2.25907470
77Fat malabsorption (HP:0002630)2.25594094
78Thickened helices (HP:0000391)2.24909994
79Fair hair (HP:0002286)2.24602479
80Volvulus (HP:0002580)2.21667010
81Abnormality of the anterior horn cell (HP:0006802)2.18875381
82Degeneration of anterior horn cells (HP:0002398)2.18875381
83Sparse lateral eyebrow (HP:0005338)2.17228465
84Papillary thyroid carcinoma (HP:0002895)2.15937636
85Hyperglycinuria (HP:0003108)2.15702022
86Short humerus (HP:0005792)2.15004916
87Intention tremor (HP:0002080)2.13196103
88Drooling (HP:0002307)2.12922129
89Excessive salivation (HP:0003781)2.12922129
90Ependymoma (HP:0002888)2.12072777
91Generalized myoclonic seizures (HP:0002123)2.11356291
92Aplasia involving bones of the upper limbs (HP:0009823)2.11292398
93Aplasia of the phalanges of the hand (HP:0009802)2.11292398
94Aplasia involving bones of the extremities (HP:0009825)2.11292398
95Ascites (HP:0001541)2.10093355
96Abnormal foot bone ossification (HP:0010675)2.10028076
97Neoplasm of the small intestine (HP:0100833)2.09573756
98Dysmetria (HP:0001310)2.08655438
99Abnormality of midbrain morphology (HP:0002418)2.07506460
100Molar tooth sign on MRI (HP:0002419)2.07506460
101Hypoplastic left heart (HP:0004383)2.07222407
102Myokymia (HP:0002411)2.05413150
103Aplasia/hypoplasia of the humerus (HP:0006507)2.04168613
104Abnormality of dentin (HP:0010299)2.03091957
105Meningocele (HP:0002435)2.03031941
106Vaginal atresia (HP:0000148)2.02909052
107Pancreatic islet-cell hyperplasia (HP:0004510)2.02538656
108Dry hair (HP:0011359)2.01944212
109Infantile muscular hypotonia (HP:0008947)2.01901965
110Vascular tortuosity (HP:0004948)2.01179766
111Hypoplasia of the iris (HP:0007676)2.01148481
112Abnormality of vitamin metabolism (HP:0100508)2.00609888
113Arterial tortuosity (HP:0005116)2.00352736
114Abnormality of the renal cortex (HP:0011035)2.00257602
115Morphological abnormality of the middle ear (HP:0008609)1.99804825
116Abnormality of the astrocytes (HP:0100707)1.99194970
117Astrocytoma (HP:0009592)1.99194970
118Genital tract atresia (HP:0001827)1.98605022
119Neoplasm of the rectum (HP:0100743)1.98123660
120Abnormality of alanine metabolism (HP:0010916)1.97849498
121Hyperalaninemia (HP:0003348)1.97849498
122Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97849498
123Pheochromocytoma (HP:0002666)1.97192984
124Barrel-shaped chest (HP:0001552)1.96883097
125Glioma (HP:0009733)1.96597923
126Truncal ataxia (HP:0002078)1.95974007
127Coronal craniosynostosis (HP:0004440)1.95439553
128Type II lissencephaly (HP:0007260)1.94772765
129Abnormal respiratory motile cilium physiology (HP:0012261)1.94122137
130Abnormality of the axillary hair (HP:0100134)1.92924646
131Abnormality of secondary sexual hair (HP:0009888)1.92924646
132Anal stenosis (HP:0002025)1.92769565
133Intellectual disability, moderate (HP:0002342)1.92676636
134Abnormality of the duodenum (HP:0002246)1.92300798
135Abnormality of the parathyroid morphology (HP:0011766)1.92189262
136Abnormality of vitamin B metabolism (HP:0004340)1.91998976
137Generalized hypopigmentation of hair (HP:0011358)1.91380698
138Scanning speech (HP:0002168)1.91276342
139Small intestinal stenosis (HP:0012848)1.90895866
140Duodenal stenosis (HP:0100867)1.90895866
141Abnormality of the intrinsic pathway (HP:0010989)1.90821339
142Hyperinsulinemic hypoglycemia (HP:0000825)1.90683640
143Adrenal hypoplasia (HP:0000835)1.90635333
144Progressive inability to walk (HP:0002505)1.90257342
145Abnormality of the umbilical cord (HP:0010881)1.89557399
146Cortical dysplasia (HP:0002539)1.89271532
147Azoospermia (HP:0000027)1.88892576
148Alacrima (HP:0000522)1.88694799
149Midline defect of the nose (HP:0004122)1.88567327
150Hypoplastic pelvis (HP:0008839)1.88139680
151Tubulointerstitial nephritis (HP:0001970)1.87723603
152Ketoacidosis (HP:0001993)1.87676338
153Neonatal hypoglycemia (HP:0001998)1.86888041
154Preauricular pit (HP:0004467)1.86563150
155Periauricular skin pits (HP:0100277)1.86563150
156Partial agenesis of the corpus callosum (HP:0001338)1.86206193
157Torticollis (HP:0000473)1.85789818
158Abnormal pancreas size (HP:0012094)1.83320179
159Spastic gait (HP:0002064)1.81972883
160Abnormal ciliary motility (HP:0012262)1.80871670
161Buphthalmos (HP:0000557)1.80669464
162Conjugated hyperbilirubinemia (HP:0002908)1.79957160
163Type I transferrin isoform profile (HP:0003642)1.79868453
164Embryonal neoplasm (HP:0002898)1.79341243
165Sensorimotor neuropathy (HP:0007141)1.78706206
166Abnormality of incisor morphology (HP:0011063)1.78295648
167Neuroendocrine neoplasm (HP:0100634)1.77552266
168Protruding tongue (HP:0010808)1.76874800
169Abnormality of the vitamin B12 metabolism (HP:0004341)1.76762485
170Clumsiness (HP:0002312)1.76191688
171Hypoglycemic seizures (HP:0002173)1.76012866
172Skin pits (HP:0100276)1.74958215
173Dynein arm defect of respiratory motile cilia (HP:0012255)1.74470524
174Absent/shortened dynein arms (HP:0200106)1.74470524
175Abnormality of the prostate (HP:0008775)1.74409841
176Lower limb muscle weakness (HP:0007340)1.73273424
177Absent eyelashes (HP:0000561)1.71787893
178Absent radius (HP:0003974)1.71616401
179Abnormality of serum amino acid levels (HP:0003112)1.71567624
180Decreased lacrimation (HP:0000633)1.71365037
181Hypothermia (HP:0002045)1.71255903
182Bell-shaped thorax (HP:0001591)1.71149702
183White forelock (HP:0002211)1.71144292
184Epileptiform EEG discharges (HP:0011182)1.70766703
185Mitral stenosis (HP:0001718)1.70380769
186Abnormality of glycolysis (HP:0004366)1.69708277
187Increased serum pyruvate (HP:0003542)1.69708277
188Poor speech (HP:0002465)1.68548325
189Cupped ear (HP:0000378)1.68510813
190Stereotypic behavior (HP:0000733)1.68484201
191Lissencephaly (HP:0001339)1.68390760
192Progressive cerebellar ataxia (HP:0002073)1.67932223
193Focal dystonia (HP:0004373)1.67623328
194Gait imbalance (HP:0002141)1.66366663

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD34.03258350
2EIF2AK33.88716356
3FGFR23.33054479
4EIF2AK12.94092716
5GRK12.91898851
6TAF12.91085340
7MARK12.76335502
8NEK92.72688714
9STK392.72296528
10BRSK22.71936649
11PBK2.64789747
12ACVR1B2.49238056
13MST42.44619419
14CASK2.40169321
15NTRK32.33893066
16SCYL22.19799231
17OXSR12.14220482
18EPHA42.10763051
19NEK12.10387187
20TSSK62.06243596
21STK38L2.02420995
22TNIK2.00254905
23PAK31.96030016
24MKNK21.94279709
25LATS11.81434620
26MKNK11.80570858
27WEE11.80301542
28AKT31.78568802
29CAMK1G1.76614688
30PLK41.73737053
31FRK1.72375345
32BRD41.71354422
33WNK31.57869849
34CAMK2B1.52854233
35PAK61.52216186
36BMPR1B1.50266207
37MAP2K71.48381354
38CAMKK21.47412259
39PKN11.46041043
40BCR1.43288871
41CSNK1A1L1.42239283
42CSNK1G21.41389270
43TTK1.40322248
44CCNB11.39017534
45SGK2231.38674747
46SGK4941.38674747
47CAMK2D1.38358379
48NTRK21.36944786
49MAP3K41.36053394
50MAPK131.35205485
51IRAK21.30037792
52MAP3K131.28884938
53TRIM281.27691276
54SRPK11.26755975
55STK31.25133401
56NUAK11.24505341
57ZAK1.22359017
58MINK11.22257660
59PHKG11.21681784
60PHKG21.21681784
61EPHB11.20735241
62TESK21.19279807
63FER1.18262976
64MARK21.17519720
65ICK1.16776059
66ERBB31.15817757
67CAMK1D1.14542019
68WNK11.13150085
69PLK31.13001322
70PRPF4B1.12551319
71PRKCQ1.12076364
72CDK51.09870566
73CSNK1G31.09644599
74FGR1.09499682
75CDK71.09339759
76YES11.08263479
77ROCK21.07530760
78CSNK1G11.05621647
79CAMK2A1.05203666
80ADRBK21.04516116
81PLK21.01938125
82MAP3K71.00367258
83FYN0.99574715
84PRKCE0.98011843
85SIK30.98001104
86KSR10.97465671
87MELK0.97437489
88ERBB40.97125819
89SGK20.96181388
90CAMK2G0.95462984
91TGFBR10.92650182
92MAPKAPK50.90798170
93MAP2K40.90613564
94CDK60.90556160
95PRKCH0.89712971
96EIF2AK20.88255521
97RIPK40.88152899
98TNK20.87310630
99CDK30.87139496
100TIE10.85069317
101TEC0.84453028
102PLK10.81051081
103IRAK10.79540832
104DDR20.77252434
105CLK10.74912140
106ATR0.74894257
107PRKCG0.74237893
108ATM0.73608583
109NEK20.73393135
110TYRO30.73322541
111SIK10.72891822
112CDC70.72550579
113SGK30.69582676
114FES0.69372914
115RIPK10.68787314
116PTK2B0.68476394
117CDK180.67686310
118MAP3K120.67347941
119NTRK10.66790372
120CDK190.65373648
121DYRK1A0.65224051
122INSR0.65100151
123MAP3K140.64152115
124FGFR30.63847704
125PNCK0.63615964
126PRKD10.63450648
127BRSK10.63163941
128CDK140.62141042
129CDK150.61741378
130BMPR20.61344342
131SGK10.61296965
132PIK3CA0.59483754
133STK110.59120278
134PRKG10.57944027
135BUB10.56971770
136BLK0.56397088
137UHMK10.56217185
138STK40.56116544
139GRK60.55716703
140RET0.55427368
141CAMK10.54460310
142PDGFRB0.53677697
143IRAK40.53673938
144NLK0.49648257
145LMTK20.49580592
146PAK20.49511799
147PRKAA20.48932719
148CHEK20.48870100
149DAPK20.48770100
150FGFR10.48353114
151VRK10.47674669
152WNK40.47113705
153DMPK0.46214955
154CDK11A0.45406879
155SRC0.43984291
156SIK20.43518424
157MAP3K90.43269942
158CHEK10.39918783
159AURKB0.38270392
160FLT30.37471640
161RPS6KA40.35878433
162PASK0.35081734
163PDK20.31677349
164STK100.29121451
165STK240.28271438
166CDK10.26504612
167PIK3CG0.26265048
168PRKDC0.25269163
169CDK40.25019080
170MAPK100.23090489
171IGF1R0.22798124
172STK160.20614826
173RPS6KB10.19288295

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047404.53200919
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.07459383
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.65683166
4Non-homologous end-joining_Homo sapiens_hsa034502.44615346
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.38428147
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.34790626
7Protein export_Homo sapiens_hsa030602.24991503
8Steroid biosynthesis_Homo sapiens_hsa001002.22280215
9Pyruvate metabolism_Homo sapiens_hsa006202.06457671
10Nicotine addiction_Homo sapiens_hsa050332.02575572
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.98338334
12Glutamatergic synapse_Homo sapiens_hsa047241.94373242
13Morphine addiction_Homo sapiens_hsa050321.93047685
14Vitamin digestion and absorption_Homo sapiens_hsa049771.92221670
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87936321
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.81424671
17Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.80211591
18Retinol metabolism_Homo sapiens_hsa008301.79871859
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79186414
20Mismatch repair_Homo sapiens_hsa034301.78844351
21Nitrogen metabolism_Homo sapiens_hsa009101.76986478
22GABAergic synapse_Homo sapiens_hsa047271.76320700
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75599655
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70325454
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.66845713
26Nucleotide excision repair_Homo sapiens_hsa034201.62638567
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.62059359
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.60942922
29Circadian entrainment_Homo sapiens_hsa047131.60933865
30Tryptophan metabolism_Homo sapiens_hsa003801.58662017
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56983647
32One carbon pool by folate_Homo sapiens_hsa006701.55677713
33Axon guidance_Homo sapiens_hsa043601.53309469
34Fanconi anemia pathway_Homo sapiens_hsa034601.52178596
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.51526946
36Basal transcription factors_Homo sapiens_hsa030221.49987963
37Fatty acid biosynthesis_Homo sapiens_hsa000611.44928851
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43738651
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.41979299
40Salivary secretion_Homo sapiens_hsa049701.41974973
41Phenylalanine metabolism_Homo sapiens_hsa003601.41535455
42Dopaminergic synapse_Homo sapiens_hsa047281.32199306
43Fatty acid elongation_Homo sapiens_hsa000621.31958318
44Taste transduction_Homo sapiens_hsa047421.26959447
45Homologous recombination_Homo sapiens_hsa034401.22574123
46Long-term potentiation_Homo sapiens_hsa047201.21493460
47Sphingolipid metabolism_Homo sapiens_hsa006001.20967659
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.19208674
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.18652482
50Serotonergic synapse_Homo sapiens_hsa047261.18642645
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17207815
52cAMP signaling pathway_Homo sapiens_hsa040241.16571027
53Gastric acid secretion_Homo sapiens_hsa049711.15548405
54N-Glycan biosynthesis_Homo sapiens_hsa005101.14016671
55Cholinergic synapse_Homo sapiens_hsa047251.13151623
56Starch and sucrose metabolism_Homo sapiens_hsa005001.12458812
57RNA transport_Homo sapiens_hsa030131.11333262
58Renin secretion_Homo sapiens_hsa049241.10162684
59Renin-angiotensin system_Homo sapiens_hsa046141.08141935
60Caffeine metabolism_Homo sapiens_hsa002321.06892490
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06834508
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06141620
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06073819
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05470520
65Synaptic vesicle cycle_Homo sapiens_hsa047211.04006689
66Insulin secretion_Homo sapiens_hsa049111.03738116
67Chemical carcinogenesis_Homo sapiens_hsa052041.02070036
68Arginine and proline metabolism_Homo sapiens_hsa003301.02038317
69Butanoate metabolism_Homo sapiens_hsa006501.01561208
70Cell cycle_Homo sapiens_hsa041101.01125888
71Amphetamine addiction_Homo sapiens_hsa050311.01036584
72Lysine degradation_Homo sapiens_hsa003100.98871827
73Vibrio cholerae infection_Homo sapiens_hsa051100.97877549
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96991568
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96586243
76Calcium signaling pathway_Homo sapiens_hsa040200.96068617
77Carbon metabolism_Homo sapiens_hsa012000.95805773
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94351962
79Ether lipid metabolism_Homo sapiens_hsa005650.89452285
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89073084
81Fatty acid metabolism_Homo sapiens_hsa012120.88955637
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88918733
83Cocaine addiction_Homo sapiens_hsa050300.87505629
84Proteasome_Homo sapiens_hsa030500.86806490
85TGF-beta signaling pathway_Homo sapiens_hsa043500.85065643
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84884107
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83951601
88RNA degradation_Homo sapiens_hsa030180.83212590
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.82248745
90Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82235742
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81579805
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79642842
93Sulfur metabolism_Homo sapiens_hsa009200.78615279
94Bile secretion_Homo sapiens_hsa049760.78266345
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77681003
96p53 signaling pathway_Homo sapiens_hsa041150.77656226
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75465220
98Oxytocin signaling pathway_Homo sapiens_hsa049210.75278689
99Propanoate metabolism_Homo sapiens_hsa006400.74656674
100Selenocompound metabolism_Homo sapiens_hsa004500.74316045
101Thyroid hormone synthesis_Homo sapiens_hsa049180.73857435
102Histidine metabolism_Homo sapiens_hsa003400.73758740
103Long-term depression_Homo sapiens_hsa047300.73754657
104Ovarian steroidogenesis_Homo sapiens_hsa049130.72704891
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.72515559
106Melanogenesis_Homo sapiens_hsa049160.72286881
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.70971737
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70781240
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69358815
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68269483
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68228557
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.67866897
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67172034
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.66116633
115DNA replication_Homo sapiens_hsa030300.64146163
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63979251
117Glioma_Homo sapiens_hsa052140.62774627
118Renal cell carcinoma_Homo sapiens_hsa052110.62752656
119Collecting duct acid secretion_Homo sapiens_hsa049660.62375114
120ErbB signaling pathway_Homo sapiens_hsa040120.61666109
121Dilated cardiomyopathy_Homo sapiens_hsa054140.61627411
122Tyrosine metabolism_Homo sapiens_hsa003500.60839174
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.60657851
124Peroxisome_Homo sapiens_hsa041460.59725200
125Thyroid cancer_Homo sapiens_hsa052160.58808070
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57844766
127GnRH signaling pathway_Homo sapiens_hsa049120.57749692
128Base excision repair_Homo sapiens_hsa034100.56718525
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55646540
130Dorso-ventral axis formation_Homo sapiens_hsa043200.55288870
131Rap1 signaling pathway_Homo sapiens_hsa040150.55002284
132Estrogen signaling pathway_Homo sapiens_hsa049150.54625840
133Ras signaling pathway_Homo sapiens_hsa040140.54568931
134B cell receptor signaling pathway_Homo sapiens_hsa046620.54480190
135Metabolic pathways_Homo sapiens_hsa011000.54344418
136Glutathione metabolism_Homo sapiens_hsa004800.54273122
137Gap junction_Homo sapiens_hsa045400.54152940
138beta-Alanine metabolism_Homo sapiens_hsa004100.53797634
139Oocyte meiosis_Homo sapiens_hsa041140.53083169
140Maturity onset diabetes of the young_Homo sapiens_hsa049500.52772282
141Choline metabolism in cancer_Homo sapiens_hsa052310.50476542
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50278492
143Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49451556
144Alcoholism_Homo sapiens_hsa050340.48986466
145Phagosome_Homo sapiens_hsa041450.48683424
146Intestinal immune network for IgA production_Homo sapiens_hsa046720.48456063
147Phototransduction_Homo sapiens_hsa047440.48077998
148Linoleic acid metabolism_Homo sapiens_hsa005910.48013623
149Chemokine signaling pathway_Homo sapiens_hsa040620.47115453
150Malaria_Homo sapiens_hsa051440.45990080
151mRNA surveillance pathway_Homo sapiens_hsa030150.43652319
152ABC transporters_Homo sapiens_hsa020100.43367371
153Arginine biosynthesis_Homo sapiens_hsa002200.42902139
154Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41859294
155Pancreatic secretion_Homo sapiens_hsa049720.41725517
156PPAR signaling pathway_Homo sapiens_hsa033200.41698320
157Prostate cancer_Homo sapiens_hsa052150.41369196
158Biosynthesis of amino acids_Homo sapiens_hsa012300.39782376
159Rheumatoid arthritis_Homo sapiens_hsa053230.39181406
160Complement and coagulation cascades_Homo sapiens_hsa046100.39049478
161ECM-receptor interaction_Homo sapiens_hsa045120.38783966
162Platelet activation_Homo sapiens_hsa046110.38548093
163Fatty acid degradation_Homo sapiens_hsa000710.38292758
164Type II diabetes mellitus_Homo sapiens_hsa049300.36806856
165Folate biosynthesis_Homo sapiens_hsa007900.34053697
166Spliceosome_Homo sapiens_hsa030400.31460016
167Small cell lung cancer_Homo sapiens_hsa052220.29035523
168Mineral absorption_Homo sapiens_hsa049780.28220384
169Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28037844
170Adherens junction_Homo sapiens_hsa045200.26129389
171alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22556215
172Circadian rhythm_Homo sapiens_hsa047100.20718146

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