MANF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)9.62109089
2COPI coating of Golgi vesicle (GO:0048205)9.62109089
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)8.41356574
4protein retention in ER lumen (GO:0006621)7.09477627
5signal peptide processing (GO:0006465)7.07078238
6ribosomal small subunit biogenesis (GO:0042274)6.09168361
7protein maturation by protein folding (GO:0022417)6.04805952
8COPII vesicle coating (GO:0048208)5.78672013
9activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.74775844
10positive regulation of nuclease activity (GO:0032075)5.66893148
11sequestering of metal ion (GO:0051238)5.28654858
12regulation of nuclease activity (GO:0032069)5.27875358
13endoplasmic reticulum unfolded protein response (GO:0030968)5.08845798
14maturation of SSU-rRNA (GO:0030490)5.08216700
15retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.02211899
16cellular response to unfolded protein (GO:0034620)4.96811938
17ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.95175860
18cellular response to topologically incorrect protein (GO:0035967)4.80414091
19ER-nucleus signaling pathway (GO:0006984)4.60091457
20exocrine pancreas development (GO:0031017)4.48436223
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.45508028
22folic acid-containing compound biosynthetic process (GO:0009396)4.37552555
23protein targeting to ER (GO:0045047)4.35154175
24cotranslational protein targeting to membrane (GO:0006613)4.31027148
25protein N-linked glycosylation via asparagine (GO:0018279)4.30529224
26peptidyl-asparagine modification (GO:0018196)4.25568237
27response to endoplasmic reticulum stress (GO:0034976)4.17298701
28establishment of protein localization to endoplasmic reticulum (GO:0072599)4.13813845
29protein localization to endoplasmic reticulum (GO:0070972)4.12918516
30regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.07002836
31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.05774020
32ribosomal large subunit biogenesis (GO:0042273)4.04318926
33GDP-mannose metabolic process (GO:0019673)4.01207573
34viral life cycle (GO:0019058)3.93829636
35protein N-linked glycosylation (GO:0006487)3.93056066
36ER overload response (GO:0006983)3.89173182
37endocrine pancreas development (GO:0031018)3.88867133
38ribonucleoprotein complex biogenesis (GO:0022613)3.83970859
39* response to unfolded protein (GO:0006986)3.81663705
40vesicle coating (GO:0006901)3.80997730
41* response to topologically incorrect protein (GO:0035966)3.71664186
42cellular protein complex disassembly (GO:0043624)3.71294316
43UDP-N-acetylglucosamine metabolic process (GO:0006047)3.66173962
44pteridine-containing compound biosynthetic process (GO:0042559)3.65983143
45proline biosynthetic process (GO:0006561)3.52892148
46peptide hormone processing (GO:0016486)3.51124793
474-hydroxyproline metabolic process (GO:0019471)3.48190491
48cell redox homeostasis (GO:0045454)3.40487936
49establishment of integrated proviral latency (GO:0075713)3.39068283
50mitotic metaphase plate congression (GO:0007080)3.37249212
51chaperone-mediated protein transport (GO:0072321)3.36294660
52mitotic chromosome condensation (GO:0007076)3.36257284
53glandular epithelial cell differentiation (GO:0002067)3.34207761
54DNA deamination (GO:0045006)3.31084557
55ER to Golgi vesicle-mediated transport (GO:0006888)3.27385758
56nucleotide-sugar biosynthetic process (GO:0009226)3.19430156
57protein complex disassembly (GO:0043241)3.18521683
58establishment of viral latency (GO:0019043)3.12152560
59establishment of protein localization to mitochondrial membrane (GO:0090151)3.08733605
60ribosome biogenesis (GO:0042254)3.06455370
61rRNA processing (GO:0006364)3.00911849
62ribosomal small subunit assembly (GO:0000028)2.97808968
63mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.96861866
64macromolecular complex disassembly (GO:0032984)2.96173896
65regulation of mitochondrial translation (GO:0070129)2.94545323
66formation of translation preinitiation complex (GO:0001731)2.92259701
67chaperone-mediated protein folding (GO:0061077)2.91844663
68protein targeting to membrane (GO:0006612)2.91567089
69regulation of type B pancreatic cell apoptotic process (GO:2000674)2.90794913
70heterochromatin organization (GO:0070828)2.90748461
71protein autoprocessing (GO:0016540)2.90640374
72tetrahydrofolate metabolic process (GO:0046653)2.89344476
73regulation of translational termination (GO:0006449)2.88568093
74translation (GO:0006412)2.86446790
75regulation of translational fidelity (GO:0006450)2.86210743
76maintenance of protein localization in organelle (GO:0072595)2.83228650
77ribosome assembly (GO:0042255)2.80304661
78cellular component biogenesis (GO:0044085)2.78639552
79rRNA metabolic process (GO:0016072)2.78386897
80DNA strand elongation involved in DNA replication (GO:0006271)2.78011939
81negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.77167596
82nuclear envelope reassembly (GO:0031468)2.76033706
83mitotic nuclear envelope reassembly (GO:0007084)2.76033706
84nucleotide-sugar metabolic process (GO:0009225)2.74733507
85hemidesmosome assembly (GO:0031581)2.72280557
86DNA strand elongation (GO:0022616)2.72192318
87protein localization to chromosome, centromeric region (GO:0071459)2.71470302
88viral transcription (GO:0019083)2.70886619
89negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.69826675
90DNA unwinding involved in DNA replication (GO:0006268)2.69808865
91L-alpha-amino acid transmembrane transport (GO:1902475)2.69542950
92negative regulation of glycoprotein biosynthetic process (GO:0010561)2.68958924
93translational termination (GO:0006415)2.68849678
94transcription elongation from RNA polymerase III promoter (GO:0006385)2.68100632
95termination of RNA polymerase III transcription (GO:0006386)2.68100632
96nuclear-transcribed mRNA catabolic process (GO:0000956)2.67421428
97antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.66612440
98proteasome assembly (GO:0043248)2.66316966
99antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.63925088
100maternal placenta development (GO:0001893)2.63482795
101negative regulation of ligase activity (GO:0051352)2.61568899
102negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.61568899
103spliceosomal snRNP assembly (GO:0000387)2.60592670
104peptide catabolic process (GO:0043171)2.60167064
105translational elongation (GO:0006414)2.58467201
106antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.58203354
107protein folding (GO:0006457)2.54693946
108mRNA catabolic process (GO:0006402)2.53992130
109nucleobase-containing small molecule interconversion (GO:0015949)2.53406641
110serine family amino acid biosynthetic process (GO:0009070)2.52338396
111cellular protein complex localization (GO:0034629)2.51944285
112intestinal cholesterol absorption (GO:0030299)2.51067462
113L-serine metabolic process (GO:0006563)2.51001253
114negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.50188719
115antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.49553696
116antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.49553696
117pseudouridine synthesis (GO:0001522)2.49498314
118cell adhesion mediated by integrin (GO:0033627)2.49418249
119regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.49398568
120anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.47960006
121metaphase plate congression (GO:0051310)2.47631913
122dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.47195816
123telomere maintenance via semi-conservative replication (GO:0032201)2.46508226
124RNA catabolic process (GO:0006401)2.44827222
125CENP-A containing nucleosome assembly (GO:0034080)2.44758985
126protein targeting to mitochondrion (GO:0006626)2.44234272
127pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.43966263
128deoxyribose phosphate biosynthetic process (GO:0046385)2.43651879
1292-deoxyribonucleotide biosynthetic process (GO:0009265)2.43651879
130rRNA transcription (GO:0009303)2.43580731
131translational initiation (GO:0006413)2.43369174
132peptidyl-glutamic acid carboxylation (GO:0017187)2.43190875
133protein carboxylation (GO:0018214)2.43190875
134regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.42447320
135intestinal epithelial cell development (GO:0060576)2.42395348
136pinocytosis (GO:0006907)2.41877875
137mitochondrial calcium ion transport (GO:0006851)2.40943381
138chaperone mediated protein folding requiring cofactor (GO:0051085)2.40024594
139cellular response to glucose starvation (GO:0042149)2.39485089
140establishment of protein localization to membrane (GO:0090150)2.39442892
141chromatin remodeling at centromere (GO:0031055)2.38301946
142regulation of glucokinase activity (GO:0033131)2.37756689
143regulation of hexokinase activity (GO:1903299)2.37756689
144type B pancreatic cell development (GO:0003323)2.37422339
145protein localization to kinetochore (GO:0034501)2.36308314
146nucleobase biosynthetic process (GO:0046112)2.36085639
147deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.35999258
148positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.35566469
149folic acid-containing compound metabolic process (GO:0006760)2.35192496
150Golgi organization (GO:0007030)2.33780485
151protein complex localization (GO:0031503)2.33666765
152regulation of retinoic acid receptor signaling pathway (GO:0048385)2.33007598
153skin morphogenesis (GO:0043589)2.32877612
154response to testosterone (GO:0033574)2.32442809
155protein peptidyl-prolyl isomerization (GO:0000413)2.32304972
156pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.31869112
157glandular epithelial cell development (GO:0002068)2.31390065
158pteridine-containing compound metabolic process (GO:0042558)2.31006079
159cellular response to vitamin D (GO:0071305)2.30342817
160proline metabolic process (GO:0006560)2.28999068
161folic acid metabolic process (GO:0046655)2.28630759
162peptidyl-proline hydroxylation (GO:0019511)2.28145468
163peptidyl-proline modification (GO:0018208)2.26985710
164intestinal absorption (GO:0050892)2.26615129
165pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.26442823
166UMP biosynthetic process (GO:0006222)2.26442823
167UMP metabolic process (GO:0046049)2.26442823

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.16585074
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.45604275
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.16764448
4E2F7_22180533_ChIP-Seq_HELA_Human3.14975772
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.13950483
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.13754265
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.13580892
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.74855609
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69706659
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.58484615
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.56722878
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.48818566
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.45007897
14ZNF263_19887448_ChIP-Seq_K562_Human2.34701792
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27600573
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.22380109
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.18267106
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.16464315
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12007164
20DCP1A_22483619_ChIP-Seq_HELA_Human2.07966432
21VDR_23849224_ChIP-Seq_CD4+_Human1.95765511
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.93758588
23MYC_19079543_ChIP-ChIP_MESCs_Mouse1.92216292
24DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.91526900
25E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91005253
26GABP_19822575_ChIP-Seq_HepG2_Human1.90727059
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89189608
28* XRN2_22483619_ChIP-Seq_HELA_Human1.88793502
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85572650
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84277652
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.82336708
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82147337
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76073748
34ZFX_18555785_ChIP-Seq_MESCs_Mouse1.74395272
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67741684
36TFEB_21752829_ChIP-Seq_HELA_Human1.64425366
37FOXP3_21729870_ChIP-Seq_TREG_Human1.64201764
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.63155306
39ERG_20887958_ChIP-Seq_HPC-7_Mouse1.58206492
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58140705
41* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55685967
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54390435
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52958829
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52474528
45ELK1_19687146_ChIP-ChIP_HELA_Human1.52447597
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.50440022
47MYC_22102868_ChIP-Seq_BL_Human1.50434115
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49586784
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.49294764
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.48915339
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44102307
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.43865860
53CLOCK_20551151_ChIP-Seq_293T_Human1.43611565
54HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.42260243
55KDM5A_27292631_Chip-Seq_BREAST_Human1.41492645
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.40678460
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40640186
58TTF2_22483619_ChIP-Seq_HELA_Human1.38306468
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.34665491
60GATA1_22025678_ChIP-Seq_K562_Human1.34629405
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33948816
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33158194
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32457698
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31785171
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31352884
66KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30883356
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30818746
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29801355
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.27972309
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25999662
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24636497
72ELK1_22589737_ChIP-Seq_MCF10A_Human1.24359661
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23898153
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23322483
75HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22584557
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21280068
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19964711
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.19353768
79RACK7_27058665_Chip-Seq_MCF-7_Human1.17922964
80* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17855064
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16728280
82SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16482893
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14675229
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.13069598
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12750099
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12512113
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12142666
88OCT4_18692474_ChIP-Seq_MEFs_Mouse1.11878497
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09782332
90SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08948497
91AR_21909140_ChIP-Seq_LNCAP_Human1.08813712
92CIITA_25753668_ChIP-Seq_RAJI_Human1.08484920
93LXR_22292898_ChIP-Seq_THP-1_Human1.07825598
94YY1_21170310_ChIP-Seq_MESCs_Mouse1.07102106
95SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06773199
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06521257
97VDR_21846776_ChIP-Seq_THP-1_Human1.06148828
98POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05950363
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05817671
100SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05472749
101* SPI1_23547873_ChIP-Seq_NB4_Human1.05375464
102KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03845844
103KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03845844
104KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03845844
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02006021
106TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01667806
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01420511
108STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01273085
109CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01142098
110NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00906144
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00896637
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99211050
113KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99173999
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98453113
115* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98310107
116CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97978394
117TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96971223
118CHD1_26751641_Chip-Seq_LNCaP_Human0.96659816
119IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96442605
120EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96095471
121TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95121165
122* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94818985
123TET1_21451524_ChIP-Seq_MESCs_Mouse0.94478199
124LXR_22158963_ChIP-Seq_LIVER_Mouse0.93461839
125ATF3_27146783_Chip-Seq_COLON_Human0.93192007
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92913957
127MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92485996

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.67101408
2MP0003693_abnormal_embryo_hatching3.36867969
3MP0005220_abnormal_exocrine_pancreas3.21174606
4MP0003941_abnormal_skin_development3.07579713
5MP0002693_abnormal_pancreas_physiology2.80710040
6MP0009379_abnormal_foot_pigmentation2.75186922
7MP0006054_spinal_hemorrhage2.72300560
8MP0001944_abnormal_pancreas_morphology2.67566645
9MP0003195_calcinosis2.46112367
10MP0003283_abnormal_digestive_organ2.39131604
11MP0002139_abnormal_hepatobiliary_system2.35220713
12MP0005365_abnormal_bile_salt2.04909731
13MP0004272_abnormal_basement_membrane1.99269250
14MP0004264_abnormal_extraembryonic_tissu1.99141255
15MP0004043_abnormal_pH_regulation1.96742975
16MP0004957_abnormal_blastocyst_morpholog1.96265699
17MP0003183_abnormal_peptide_metabolism1.95065255
18MP0000678_abnormal_parathyroid_gland1.94259411
19MP0009053_abnormal_anal_canal1.89400490
20MP0003300_gastrointestinal_ulcer1.86966530
21MP0002796_impaired_skin_barrier1.86049179
22MP0010030_abnormal_orbit_morphology1.85318446
23MP0001666_abnormal_nutrient_absorption1.83480712
24MP0005451_abnormal_body_composition1.82913620
25MP0000013_abnormal_adipose_tissue1.81558003
26MP0008438_abnormal_cutaneous_collagen1.80717210
27MP0004185_abnormal_adipocyte_glucose1.70894526
28MP0001849_ear_inflammation1.70141312
29MP0005083_abnormal_biliary_tract1.68680713
30MP0010234_abnormal_vibrissa_follicle1.68453980
31MP0003806_abnormal_nucleotide_metabolis1.66574600
32MP0003453_abnormal_keratinocyte_physiol1.61271129
33MP0004858_abnormal_nervous_system1.60041563
34MP0003705_abnormal_hypodermis_morpholog1.57547790
35MP0009643_abnormal_urine_homeostasis1.57534405
36MP0005501_abnormal_skin_physiology1.49834415
37MP0003868_abnormal_feces_composition1.44851036
38MP0010094_abnormal_chromosome_stability1.44061549
39MP0005379_endocrine/exocrine_gland_phen1.43975090
40MP0002138_abnormal_hepatobiliary_system1.42876732
41MP0010352_gastrointestinal_tract_polyps1.40693831
42MP0005623_abnormal_meninges_morphology1.39484117
43MP0005058_abnormal_lysosome_morphology1.34954738
44MP0000762_abnormal_tongue_morphology1.34631330
45MP0002078_abnormal_glucose_homeostasis1.34475935
46MP0003186_abnormal_redox_activity1.34299521
47MP0010386_abnormal_urinary_bladder1.33174495
48MP0003252_abnormal_bile_duct1.32941720
49MP0002909_abnormal_adrenal_gland1.31108659
50MP0005076_abnormal_cell_differentiation1.30746469
51MP0000613_abnormal_salivary_gland1.30083915
52MP0002928_abnormal_bile_duct1.29368737
53MP0000579_abnormal_nail_morphology1.29135634
54MP0003315_abnormal_perineum_morphology1.29053433
55MP0000537_abnormal_urethra_morphology1.25522072
56MP0005084_abnormal_gallbladder_morpholo1.25000302
57MP0003436_decreased_susceptibility_to1.24396162
58MP0005085_abnormal_gallbladder_physiolo1.23797803
59MP0001216_abnormal_epidermal_layer1.19683831
60MP0003566_abnormal_cell_adhesion1.18881669
61MP0005408_hypopigmentation1.18726690
62MP0001853_heart_inflammation1.18494596
63MP0002896_abnormal_bone_mineralization1.15354381
64MP0003718_maternal_effect1.15026895
65MP0009333_abnormal_splenocyte_physiolog1.13940442
66MP0005636_abnormal_mineral_homeostasis1.09627224
67MP0000858_altered_metastatic_potential1.09585511
68MP0009780_abnormal_chondrocyte_physiolo1.08898341
69MP0001881_abnormal_mammary_gland1.08768998
70MP0009697_abnormal_copulation1.07899942
71MP0008007_abnormal_cellular_replicative1.06751053
72MP0004782_abnormal_surfactant_physiolog1.05591344
73MP0001672_abnormal_embryogenesis/_devel1.04764950
74MP0005380_embryogenesis_phenotype1.04764950
75MP0002254_reproductive_system_inflammat1.04164096
76MP0005360_urolithiasis1.03638399
77MP0000627_abnormal_mammary_gland1.02745460
78MP0000490_abnormal_crypts_of1.01596372
79MP0000003_abnormal_adipose_tissue1.00107091
80MP0001756_abnormal_urination0.99075484
81MP0000609_abnormal_liver_physiology0.98380378
82MP0002089_abnormal_postnatal_growth/wei0.96155114
83MP0003984_embryonic_growth_retardation0.94828054
84MP0001845_abnormal_inflammatory_respons0.94761828
85MP0003959_abnormal_lean_body0.92197456
86MP0009840_abnormal_foam_cell0.91574455
87MP0000467_abnormal_esophagus_morphology0.91510061
88MP0000313_abnormal_cell_death0.91283662
89MP0003795_abnormal_bone_structure0.90925921
90MP0000598_abnormal_liver_morphology0.90701480
91MP0004233_abnormal_muscle_weight0.90133430
92MP0002085_abnormal_embryonic_tissue0.90038964
93MP0001533_abnormal_skeleton_physiology0.89937722
94MP0003077_abnormal_cell_cycle0.88911913
95MP0002088_abnormal_embryonic_growth/wei0.88902877
96MP0003866_abnormal_defecation0.88022682
97MP0005197_abnormal_uvea_morphology0.87503897
98MP0003123_paternal_imprinting0.87028561
99MP0003890_abnormal_embryonic-extraembry0.85321720
100MP0008932_abnormal_embryonic_tissue0.84830760
101MP0002086_abnormal_extraembryonic_tissu0.84791539
102MP0005257_abnormal_intraocular_pressure0.84558705
103MP0001764_abnormal_homeostasis0.84380399
104MP0005319_abnormal_enzyme/_coenzyme0.84257231
105MP0003724_increased_susceptibility_to0.83927691
106MP0001765_abnormal_ion_homeostasis0.83798508
107MP0003303_peritoneal_inflammation0.82408335
108MP0003448_altered_tumor_morphology0.80883850
109MP0005310_abnormal_salivary_gland0.80554034
110MP0003091_abnormal_cell_migration0.79763690
111MP0003950_abnormal_plasma_membrane0.79508999
112MP0009672_abnormal_birth_weight0.79113950
113MP0000358_abnormal_cell_content/0.79041644
114MP0001730_embryonic_growth_arrest0.78899328
115MP0000681_abnormal_thyroid_gland0.78188749
116MP0005023_abnormal_wound_healing0.78074842
117MP0000462_abnormal_digestive_system0.77680903
118MP0000566_synostosis0.76810240
119MP0000343_altered_response_to0.76655227
120MP0001542_abnormal_bone_strength0.76358662
121MP0002697_abnormal_eye_size0.76203981
122MP0008469_abnormal_protein_level0.75871288
123MP0002111_abnormal_tail_morphology0.75285351
124MP0008058_abnormal_DNA_repair0.75246551
125MP0009931_abnormal_skin_appearance0.74894916
126MP0001243_abnormal_dermal_layer0.74730517
127MP0001915_intracranial_hemorrhage0.74203480
128MP0002084_abnormal_developmental_patter0.73605352
129MP0005621_abnormal_cell_physiology0.72930619
130MP0003279_aneurysm0.71711261
131MP0010307_abnormal_tumor_latency0.71581343
132MP0003786_premature_aging0.71353154
133MP0005275_abnormal_skin_tensile0.71320142
134MP0005332_abnormal_amino_acid0.70551136
135MP0003953_abnormal_hormone_level0.70020384
136MP0000685_abnormal_immune_system0.69915061
137MP0003385_abnormal_body_wall0.69766282
138MP0004947_skin_inflammation0.68607105
139MP0008260_abnormal_autophagy0.68517596
140MP0010155_abnormal_intestine_physiology0.68300891
141MP0005508_abnormal_skeleton_morphology0.67981323
142MP0002080_prenatal_lethality0.67375773
143MP0005389_reproductive_system_phenotype0.67174619
144MP0003111_abnormal_nucleus_morphology0.64669454
145MP0000350_abnormal_cell_proliferation0.63934072
146MP0009642_abnormal_blood_homeostasis0.63540949
147MP0002160_abnormal_reproductive_system0.62886779
148MP0006036_abnormal_mitochondrial_physio0.62641998
149MP0002019_abnormal_tumor_incidence0.62497073
150MP0002060_abnormal_skin_morphology0.61976956
151MP0005390_skeleton_phenotype0.61047541
152MP0002166_altered_tumor_susceptibility0.60725616
153MP0001697_abnormal_embryo_size0.60398391
154MP0005000_abnormal_immune_tolerance0.59521096
155MP0003172_abnormal_lysosome_physiology0.59451137

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)5.62273458
2Hyperinsulinemic hypoglycemia (HP:0000825)5.31603595
3Hypoglycemic seizures (HP:0002173)5.13254922
4Abnormality of the intrinsic pathway (HP:0010989)4.42590461
5Symptomatic seizures (HP:0011145)4.37591210
6Late onset (HP:0003584)3.71031516
7Oral leukoplakia (HP:0002745)3.64302612
8Abnormality of endocrine pancreas physiology (HP:0012093)3.59039083
9Abnormality of the pancreatic islet cells (HP:0006476)3.59039083
10Generalized aminoaciduria (HP:0002909)3.52824677
11Hyperglycemia (HP:0003074)3.49489009
12Abnormal glycosylation (HP:0012345)3.42813052
13Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.42813052
14Abnormal protein N-linked glycosylation (HP:0012347)3.42813052
15Abnormal protein glycosylation (HP:0012346)3.42813052
16Abnormality of aromatic amino acid family metabolism (HP:0004338)3.31389833
17Rough bone trabeculation (HP:0100670)3.30598522
18Mucopolysacchariduria (HP:0008155)3.28366545
19Urinary glycosaminoglycan excretion (HP:0003541)3.28366545
20Type I transferrin isoform profile (HP:0003642)3.26416419
21Deep venous thrombosis (HP:0002625)3.19029394
22Dysostosis multiplex (HP:0000943)3.17510304
23Abnormality of the common coagulation pathway (HP:0010990)3.15544172
24Abnormal pancreas size (HP:0012094)3.12251443
25Macrocytic anemia (HP:0001972)3.09432532
26Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.08070508
27Degeneration of anterior horn cells (HP:0002398)3.06730058
28Abnormality of the anterior horn cell (HP:0006802)3.06730058
29Insulin-resistant diabetes mellitus (HP:0000831)3.04807905
30Thrombocytosis (HP:0001894)3.04754382
31Ketoacidosis (HP:0001993)3.02580486
32Achilles tendon contracture (HP:0001771)3.02314942
33Vacuolated lymphocytes (HP:0001922)2.99288029
34Abnormality of the Achilles tendon (HP:0005109)2.95416892
35Selective tooth agenesis (HP:0001592)2.94530504
36Insulin resistance (HP:0000855)2.94286574
37Abnormal trabecular bone morphology (HP:0100671)2.83233557
38Reduced antithrombin III activity (HP:0001976)2.82676569
39Abnormality of polysaccharide metabolism (HP:0011012)2.80625430
40Abnormality of glycosaminoglycan metabolism (HP:0004371)2.80625430
41Abnormality of mucopolysaccharide metabolism (HP:0011020)2.80625430
42Thoracolumbar scoliosis (HP:0002944)2.75654160
43Pancreatic islet-cell hyperplasia (HP:0004510)2.73579639
44Atrophic scars (HP:0001075)2.52639619
45Fragile skin (HP:0001030)2.49483039
46Beaking of vertebral bodies (HP:0004568)2.48867035
47Sparse eyelashes (HP:0000653)2.46386871
48Poor head control (HP:0002421)2.44601273
49Aplastic anemia (HP:0001915)2.39066437
50Prominent metopic ridge (HP:0005487)2.35449340
51Abnormality of monocarboxylic acid metabolism (HP:0010996)2.35444755
52Large for gestational age (HP:0001520)2.33181347
53Exocrine pancreatic insufficiency (HP:0001738)2.26791612
54Short nail (HP:0001799)2.25974021
55Abnormality of carpal bone ossification (HP:0006257)2.25690156
5611 pairs of ribs (HP:0000878)2.21286583
57Ankle contracture (HP:0006466)2.21067050
58Ketosis (HP:0001946)2.20858713
59Flat acetabular roof (HP:0003180)2.20817050
60Abdominal distention (HP:0003270)2.19468607
61Blue sclerae (HP:0000592)2.18282649
62Abnormality of dentin (HP:0010299)2.16029710
63Multiple enchondromatosis (HP:0005701)2.08311657
64Abnormality of subcutaneous fat tissue (HP:0001001)2.07727227
65Cervical subluxation (HP:0003308)2.05663262
66Abnormalities of placenta or umbilical cord (HP:0001194)2.05172339
67Vertebral compression fractures (HP:0002953)2.04404437
68Abnormality of T cell physiology (HP:0011840)2.04158203
69Pallor (HP:0000980)2.04102540
70Microvesicular hepatic steatosis (HP:0001414)2.02794618
71Osteolytic defects of the phalanges of the hand (HP:0009771)2.01268837
72Osteolytic defects of the hand bones (HP:0009699)2.01268837
73Nonimmune hydrops fetalis (HP:0001790)2.00803400
74Hyperparathyroidism (HP:0000843)2.00768049
75Increased hepatocellular lipid droplets (HP:0006565)2.00695902
76Fragile nails (HP:0001808)2.00667457
77Abnormality of the umbilical cord (HP:0010881)1.99451636
78Progressive muscle weakness (HP:0003323)1.99436592
79Spinal cord compression (HP:0002176)1.95437709
80Unilateral renal agenesis (HP:0000122)1.95395504
81Amniotic constriction ring (HP:0009775)1.94227011
82Abnormality of placental membranes (HP:0011409)1.94227011
83Elbow flexion contracture (HP:0002987)1.92971050
84Trismus (HP:0000211)1.92935774
85Acute necrotizing encephalopathy (HP:0006965)1.92880974
86Abnormality of calcium-phosphate metabolism (HP:0100530)1.91999634
87Hypoplasia of the pons (HP:0012110)1.91300848
88Abnormality of cells of the erythroid lineage (HP:0012130)1.91180461
89Onycholysis (HP:0001806)1.90528689
90Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90186518
91Protrusio acetabuli (HP:0003179)1.90172917
92Abnormal number of erythroid precursors (HP:0012131)1.90150544
93Gout (HP:0001997)1.90042682
94Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89846355
95Progressive neurologic deterioration (HP:0002344)1.89275367
96Joint stiffness (HP:0001387)1.88893700
97Missing ribs (HP:0000921)1.87729892
98Chronic bronchitis (HP:0004469)1.87269141
99Abnormal ossification of hand bones (HP:0005921)1.86823347
100Microretrognathia (HP:0000308)1.86384397
101Elevated alkaline phosphatase (HP:0003155)1.85721090
102Natal tooth (HP:0000695)1.85501323
103Abnormal tarsal ossification (HP:0008369)1.85354509
104Premature rupture of membranes (HP:0001788)1.84363011
105Fat malabsorption (HP:0002630)1.84208365
106Abnormality of the metopic suture (HP:0005556)1.83829987
107Abnormality of alkaline phosphatase activity (HP:0004379)1.83817192
108Acute encephalopathy (HP:0006846)1.83784387
109Decreased subcutaneous fat (HP:0001002)1.83702755
110Abnormality of urine glucose concentration (HP:0011016)1.83377156
111Glycosuria (HP:0003076)1.83377156
112Delayed cranial suture closure (HP:0000270)1.83297492
113Long palpebral fissure (HP:0000637)1.83188248
114Severe short stature (HP:0003510)1.82372780
115Intrahepatic cholestasis (HP:0001406)1.81706518
116Abnormal mitochondria in muscle tissue (HP:0008316)1.81019893
117Deviation of the thumb (HP:0009603)1.79261271
118Prolonged partial thromboplastin time (HP:0003645)1.78841701
119Abnormal enzyme/coenzyme activity (HP:0012379)1.77829490
120Abnormality of the acetabulum (HP:0003170)1.77741794
121Type I diabetes mellitus (HP:0100651)1.77140448
122Ridged nail (HP:0001807)1.75236265
123Renal Fanconi syndrome (HP:0001994)1.75065980
124Secondary amenorrhea (HP:0000869)1.74288774
125Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.74026219
126Vertebral hypoplasia (HP:0008417)1.74026219
127Decreased circulating renin level (HP:0003351)1.72781043
128Lipid accumulation in hepatocytes (HP:0006561)1.72491779
129Abnormality of purine metabolism (HP:0004352)1.72228973
130Cerebral edema (HP:0002181)1.71749295
131Abnormal hemoglobin (HP:0011902)1.71489003
132Pancreatitis (HP:0001733)1.70125610
133Testicular atrophy (HP:0000029)1.69415369
134Hyperphosphaturia (HP:0003109)1.69115880
135Conjugated hyperbilirubinemia (HP:0002908)1.68847803
136Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.68384370
137Congenital ichthyosiform erythroderma (HP:0007431)1.66562542
138Protuberant abdomen (HP:0001538)1.66492374
139Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.65900950
140Patent foramen ovale (HP:0001655)1.65506458
141Abnormal umbilical cord blood vessels (HP:0011403)1.65396592
142Single umbilical artery (HP:0001195)1.65396592
143Abnormality of the fetal cardiovascular system (HP:0010948)1.65396592
144Nasolacrimal duct obstruction (HP:0000579)1.64991496
145Abnormality of the distal phalanges of the toes (HP:0010182)1.64969114
146Abnormality of the pons (HP:0007361)1.64963491
147Pterygium (HP:0001059)1.64880532
148Generalized amyotrophy (HP:0003700)1.64386223
149Ankyloglossia (HP:0010296)1.64173289
150Abnormal foot bone ossification (HP:0010675)1.64169173
151Abnormality of complement system (HP:0005339)1.62439063
152Dysautonomia (HP:0002459)1.62417017
153Milia (HP:0001056)1.60947363
154Villous atrophy (HP:0011473)1.60312870
155Abnormality of small intestinal villus morphology (HP:0011472)1.60312870
156Hepatic necrosis (HP:0002605)1.59027181
157Glossoptosis (HP:0000162)1.58233911
158Back pain (HP:0003418)1.57857038
159Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.57125707
160Decreased activity of mitochondrial respiratory chain (HP:0008972)1.57125707
161Reticulocytopenia (HP:0001896)1.57079045
162Abnormality of glycolipid metabolism (HP:0010969)1.57063091
163Abnormality of liposaccharide metabolism (HP:0010968)1.57063091
164Abnormality of glycosphingolipid metabolism (HP:0004343)1.57063091
165Abnormal delivery (HP:0001787)1.56680709
166Pseudobulbar signs (HP:0002200)1.56207183
167Irregular vertebral endplates (HP:0003301)1.55196864
168Abnormal cartilage morphology (HP:0002763)1.53889991
169Upper motor neuron abnormality (HP:0002127)1.53770189
170Overlapping toe (HP:0001845)1.52709052

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.77511614
2PASK4.07874196
3VRK22.96804133
4INSRR2.88320088
5EIF2AK32.85014167
6TAOK32.64355128
7BCKDK2.63670432
8PBK2.58987122
9SMG12.54944716
10FLT32.45076272
11NME22.40803755
12SCYL22.29659670
13TESK12.25319712
14MAPK152.24584048
15EIF2AK12.22116451
16ARAF2.12713705
17TRIB32.11109239
18FRK2.01846836
19NEK11.93808880
20IRAK31.90960000
21PRPF4B1.82372774
22BRSK21.73994453
23TAOK21.67050761
24TESK21.64939192
25LATS21.62377975
26TTK1.61301727
27HIPK21.53840518
28PKN21.52902428
29BUB11.51973898
30RPS6KA41.49326301
31STK161.45107734
32PIM21.44046930
33MST1R1.41920707
34DYRK31.32886307
35WEE11.31215090
36EPHA21.28222157
37EPHB21.27423097
38MOS1.24336497
39PTK61.20090695
40STK241.19936923
41VRK11.18199348
42PIK3CG1.15633646
43IRAK41.11798939
44MAP2K21.10577200
45MAP3K91.10079033
46MAPKAPK31.07944830
47KDR1.03607844
48ABL21.03056514
49ERBB41.02542785
50MAP3K31.01876863
51STK40.98786772
52ICK0.97397720
53CDK120.97314191
54RPS6KB20.97160508
55ZAP700.96285498
56TLK10.94856793
57CHEK20.94856272
58JAK30.92433374
59MAP3K110.92408107
60LRRK20.91598980
61TAF10.88436290
62ACVR1B0.86084700
63DYRK1B0.85531486
64MAP3K100.85014390
65TBK10.84823778
66CDK40.82553846
67IRAK10.81205297
68TEC0.80954809
69MAP3K80.80679456
70PAK40.78527868
71BTK0.77522178
72DDR20.77215432
73NEK90.76998960
74PRKD30.76664545
75MAP3K130.75995626
76MAP3K140.74511715
77NEK20.73582977
78BRAF0.72823524
79MAP3K20.72015711
80CDK80.71641685
81PDGFRA0.71511531
82EEF2K0.70722966
83MST40.69210053
84EPHA30.68629465
85BRSK10.68031676
86AURKB0.66939989
87NME10.66874674
88PTK20.65162064
89PLK30.64525333
90CHEK10.64257285
91CDK70.63086049
92TYK20.61766781
93LIMK10.61204778
94CDC70.61049629
95MAP3K120.60701141
96DAPK30.60492497
97PRKCI0.60253983
98STK100.60059237
99AURKA0.59587722
100MET0.59062088
101SRPK10.57838994
102NLK0.57114127
103MAP3K10.56537769
104PLK40.55893372
105LATS10.52538558
106FGFR40.52119986
107SIK10.51625724
108MAP2K30.49943981
109PLK10.49643260
110MAP4K10.49360073
111TAOK10.47134657
112LMTK20.46887389
113ALK0.46803447
114PDK20.45904038
115TGFBR10.45467717
116CAMK1D0.45168953
117PAK20.45002942
118AKT30.44099622
119CAMKK20.44014806
120ILK0.43098140
121TGFBR20.43056787
122WNK40.43020487
123ZAK0.42393774
124PIM10.41887172
125CLK10.41694297
126STK30.40860235
127DMPK0.40785510
128BLK0.40481018
129CSNK2A10.40237340
130TSSK60.39295738
131CDK60.38052971
132MAPKAPK20.37786934
133ATR0.37370573
134CSNK2A20.36613818
135CHUK0.36423065
136PAK10.35718749
137CSK0.35591249
138PRKG20.35249579
139JAK20.35156062
140ITK0.35078729
141MTOR0.32658232

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030606.88349546
2Maturity onset diabetes of the young_Homo sapiens_hsa049505.79177627
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041414.18132261
4Sulfur metabolism_Homo sapiens_hsa009202.62344194
5N-Glycan biosynthesis_Homo sapiens_hsa005102.55792914
6Selenocompound metabolism_Homo sapiens_hsa004502.34223657
7Ribosome_Homo sapiens_hsa030102.17003467
8Folate biosynthesis_Homo sapiens_hsa007902.13001177
9Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.04185116
10Proteasome_Homo sapiens_hsa030502.00236630
11One carbon pool by folate_Homo sapiens_hsa006701.92879382
12DNA replication_Homo sapiens_hsa030301.82500528
13Antigen processing and presentation_Homo sapiens_hsa046121.64882533
14Other glycan degradation_Homo sapiens_hsa005111.59921052
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59274324
16Oxidative phosphorylation_Homo sapiens_hsa001901.56108873
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42484412
18Pyrimidine metabolism_Homo sapiens_hsa002401.39593643
19Vibrio cholerae infection_Homo sapiens_hsa051101.38846753
20Parkinsons disease_Homo sapiens_hsa050121.30086340
21Legionellosis_Homo sapiens_hsa051341.27070388
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.25738876
23Galactose metabolism_Homo sapiens_hsa000521.22017948
24Fat digestion and absorption_Homo sapiens_hsa049751.20014677
25Mismatch repair_Homo sapiens_hsa034301.18853333
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16783293
27RNA polymerase_Homo sapiens_hsa030201.16241397
28Huntingtons disease_Homo sapiens_hsa050161.15130988
29Spliceosome_Homo sapiens_hsa030401.12426166
30RNA transport_Homo sapiens_hsa030131.09379863
31Base excision repair_Homo sapiens_hsa034101.09077340
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.06471305
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05674147
34Lysosome_Homo sapiens_hsa041421.05222133
35Sulfur relay system_Homo sapiens_hsa041221.05117496
36Pyruvate metabolism_Homo sapiens_hsa006201.04262378
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01703850
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.98504368
39Small cell lung cancer_Homo sapiens_hsa052220.96281447
40Arginine biosynthesis_Homo sapiens_hsa002200.95740778
41Tryptophan metabolism_Homo sapiens_hsa003800.90884772
42Type I diabetes mellitus_Homo sapiens_hsa049400.88026842
43mRNA surveillance pathway_Homo sapiens_hsa030150.86757173
44Alzheimers disease_Homo sapiens_hsa050100.84323661
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80515999
46Nucleotide excision repair_Homo sapiens_hsa034200.80309234
47Steroid biosynthesis_Homo sapiens_hsa001000.77215296
48Thyroid hormone synthesis_Homo sapiens_hsa049180.71626483
49Starch and sucrose metabolism_Homo sapiens_hsa005000.71359352
50Renin-angiotensin system_Homo sapiens_hsa046140.71222868
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69994853
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69984257
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69956779
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66929058
55p53 signaling pathway_Homo sapiens_hsa041150.66921794
56Homologous recombination_Homo sapiens_hsa034400.65903499
57Vitamin B6 metabolism_Homo sapiens_hsa007500.64235347
58Vitamin digestion and absorption_Homo sapiens_hsa049770.61972874
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61468237
60Cell cycle_Homo sapiens_hsa041100.61268840
61Glutathione metabolism_Homo sapiens_hsa004800.59931266
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59467758
63ECM-receptor interaction_Homo sapiens_hsa045120.58333187
64Protein digestion and absorption_Homo sapiens_hsa049740.58267215
65Bladder cancer_Homo sapiens_hsa052190.58038768
66Fructose and mannose metabolism_Homo sapiens_hsa000510.57971601
67Prion diseases_Homo sapiens_hsa050200.57844737
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57527431
69Pentose phosphate pathway_Homo sapiens_hsa000300.57401247
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.57386462
71Linoleic acid metabolism_Homo sapiens_hsa005910.56669594
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56532860
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56244150
74Shigellosis_Homo sapiens_hsa051310.56114829
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56104330
76Systemic lupus erythematosus_Homo sapiens_hsa053220.55348147
77Phenylalanine metabolism_Homo sapiens_hsa003600.54587529
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53739118
79Thyroid cancer_Homo sapiens_hsa052160.52537424
80Histidine metabolism_Homo sapiens_hsa003400.50634623
81HTLV-I infection_Homo sapiens_hsa051660.50285859
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.49680202
83Purine metabolism_Homo sapiens_hsa002300.49586838
84Pancreatic secretion_Homo sapiens_hsa049720.49244605
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47201722
86Epstein-Barr virus infection_Homo sapiens_hsa051690.46538076
87Viral carcinogenesis_Homo sapiens_hsa052030.45792006
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45564849
89Chronic myeloid leukemia_Homo sapiens_hsa052200.44522877
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43955077
91Biosynthesis of amino acids_Homo sapiens_hsa012300.43440425
92Arginine and proline metabolism_Homo sapiens_hsa003300.43120247
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42999853
94Pancreatic cancer_Homo sapiens_hsa052120.42705186
95Fatty acid degradation_Homo sapiens_hsa000710.42589099
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.42074158
97RNA degradation_Homo sapiens_hsa030180.41466140
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41176392
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.39739528
100Metabolic pathways_Homo sapiens_hsa011000.39149219
101Arachidonic acid metabolism_Homo sapiens_hsa005900.38740675
102Tyrosine metabolism_Homo sapiens_hsa003500.38695179
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37839135
104Proteoglycans in cancer_Homo sapiens_hsa052050.37398327
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36713265
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35931053
107Non-homologous end-joining_Homo sapiens_hsa034500.35284338
108Insulin resistance_Homo sapiens_hsa049310.35050567
109Herpes simplex infection_Homo sapiens_hsa051680.34084619
110Insulin secretion_Homo sapiens_hsa049110.32989442
111Apoptosis_Homo sapiens_hsa042100.32906402
112Carbon metabolism_Homo sapiens_hsa012000.32880549
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32385657
114Amoebiasis_Homo sapiens_hsa051460.32075636
115Complement and coagulation cascades_Homo sapiens_hsa046100.31993530
116Peroxisome_Homo sapiens_hsa041460.30448908
117Basal transcription factors_Homo sapiens_hsa030220.29853780
118Regulation of autophagy_Homo sapiens_hsa041400.28803064
119Phagosome_Homo sapiens_hsa041450.28448590
120TGF-beta signaling pathway_Homo sapiens_hsa043500.27616294
121Prostate cancer_Homo sapiens_hsa052150.26609819
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25881162
123MicroRNAs in cancer_Homo sapiens_hsa052060.24802893
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23924932
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23842687
126Pertussis_Homo sapiens_hsa051330.23074553
127NF-kappa B signaling pathway_Homo sapiens_hsa040640.21428389
128Leishmaniasis_Homo sapiens_hsa051400.20750173
129Prolactin signaling pathway_Homo sapiens_hsa049170.20649133
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19348769

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