MANSC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)7.58171731
2embryonic process involved in female pregnancy (GO:0060136)6.87067183
3regulation of integrin activation (GO:0033623)5.65057082
4phospholipid scrambling (GO:0017121)5.38692602
5GDP-mannose metabolic process (GO:0019673)5.34867826
6proline metabolic process (GO:0006560)5.28168928
7behavioral response to nicotine (GO:0035095)5.24868494
8intestinal epithelial cell development (GO:0060576)5.20884466
9establishment of apical/basal cell polarity (GO:0035089)5.17969461
10protein retention in ER lumen (GO:0006621)4.84761018
11positive regulation of protein homooligomerization (GO:0032464)4.71493417
12transcription from mitochondrial promoter (GO:0006390)4.70332091
13replication fork processing (GO:0031297)4.64053750
14maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.62840175
15DNA deamination (GO:0045006)4.57511240
16oxidative demethylation (GO:0070989)4.46898736
17establishment of monopolar cell polarity (GO:0061162)4.33130561
18establishment or maintenance of monopolar cell polarity (GO:0061339)4.33130561
19definitive hemopoiesis (GO:0060216)4.17057428
20regulation of protein homooligomerization (GO:0032462)4.04679999
21fucose catabolic process (GO:0019317)4.03780726
22L-fucose metabolic process (GO:0042354)4.03780726
23L-fucose catabolic process (GO:0042355)4.03780726
24Golgi transport vesicle coating (GO:0048200)4.00689394
25COPI coating of Golgi vesicle (GO:0048205)4.00689394
26cellular ketone body metabolic process (GO:0046950)3.93532458
27hematopoietic stem cell proliferation (GO:0071425)3.89126971
28phosphatidylinositol acyl-chain remodeling (GO:0036149)3.85731499
29positive regulation of lamellipodium assembly (GO:0010592)3.82084162
30antigen processing and presentation via MHC class Ib (GO:0002475)3.73130372
31negative regulation of stress fiber assembly (GO:0051497)3.71227285
32columnar/cuboidal epithelial cell development (GO:0002066)3.70917084
33positive regulation of lamellipodium organization (GO:1902745)3.68186289
34UDP-N-acetylglucosamine metabolic process (GO:0006047)3.67677771
35indolalkylamine metabolic process (GO:0006586)3.59300902
36maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.57605905
37poly(A)+ mRNA export from nucleus (GO:0016973)3.57085543
38negative regulation of erythrocyte differentiation (GO:0045647)3.55009985
39indole-containing compound catabolic process (GO:0042436)3.54334946
40indolalkylamine catabolic process (GO:0046218)3.54334946
41tryptophan catabolic process (GO:0006569)3.54334946
42ketone body metabolic process (GO:1902224)3.47950279
43cellular response to zinc ion (GO:0071294)3.46793582
44kynurenine metabolic process (GO:0070189)3.46286644
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.46279810
46nucleotide-sugar metabolic process (GO:0009225)3.42075143
47positive regulation of respiratory burst (GO:0060267)3.38695982
48fucose metabolic process (GO:0006004)3.34409361
49regulation of sister chromatid cohesion (GO:0007063)3.34391762
50N-glycan processing (GO:0006491)3.33591289
51regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.28379688
52detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.27350518
53tryptophan metabolic process (GO:0006568)3.24226280
54embryonic placenta development (GO:0001892)3.22063386
55antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.18922461
56antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.18922461
57nucleotide-sugar biosynthetic process (GO:0009226)3.18251004
58epithelial cilium movement (GO:0003351)3.16942448
59primary amino compound metabolic process (GO:1901160)3.16686132
60regulation of respiratory burst (GO:0060263)3.16138875
61axoneme assembly (GO:0035082)3.15419185
62response to interferon-beta (GO:0035456)3.14776251
63regulation of memory T cell differentiation (GO:0043380)3.14690162
64detection of light stimulus involved in visual perception (GO:0050908)3.14281440
65detection of light stimulus involved in sensory perception (GO:0050962)3.14281440
66fucosylation (GO:0036065)3.12399253
67sulfate transmembrane transport (GO:1902358)3.10918153
68cornea development in camera-type eye (GO:0061303)3.10066016
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.09717292
70mitochondrial DNA metabolic process (GO:0032042)3.09146393
71water-soluble vitamin biosynthetic process (GO:0042364)3.07694181
72peptide catabolic process (GO:0043171)3.04857051
73cilium or flagellum-dependent cell motility (GO:0001539)3.04521589
74preassembly of GPI anchor in ER membrane (GO:0016254)3.03688952
75adaptation of signaling pathway (GO:0023058)3.01602248
76galactose catabolic process (GO:0019388)2.99282621
77bundle of His cell to Purkinje myocyte communication (GO:0086069)2.99031159
78serotonin metabolic process (GO:0042428)2.97588390
79gamma-aminobutyric acid transport (GO:0015812)2.96636828
80trophectodermal cell differentiation (GO:0001829)2.95062238
81indole-containing compound metabolic process (GO:0042430)2.94955210
82muscle organ morphogenesis (GO:0048644)2.92711547
83phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.90408610
84membrane invagination (GO:0010324)2.90303669
85phosphatidylserine acyl-chain remodeling (GO:0036150)2.90169018
86mitotic cell cycle arrest (GO:0071850)2.88046849
87maturation of 5.8S rRNA (GO:0000460)2.86978677
88mitochondrial calcium ion transport (GO:0006851)2.86533573
89opioid receptor signaling pathway (GO:0038003)2.86507319
90platelet dense granule organization (GO:0060155)2.84969930
91sulfation (GO:0051923)2.84815846
92hepatocyte apoptotic process (GO:0097284)2.83335810
93nonmotile primary cilium assembly (GO:0035058)2.81026145
94kidney morphogenesis (GO:0060993)2.80604232
95ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.80138092
96positive regulation of Notch signaling pathway (GO:0045747)2.79428554
97signal complex assembly (GO:0007172)2.79300660
98protein targeting to vacuole (GO:0006623)2.79250876
99protein targeting to lysosome (GO:0006622)2.79250876
100establishment of protein localization to vacuole (GO:0072666)2.79250876
101regulation of lamellipodium assembly (GO:0010591)2.79122886
102cilium movement (GO:0003341)2.77467314
103negative regulation of viral release from host cell (GO:1902187)2.77119649
104negative regulation of mast cell activation (GO:0033004)2.76132139
105viral mRNA export from host cell nucleus (GO:0046784)2.75914953
106mitotic G1 DNA damage checkpoint (GO:0031571)2.75472935
107myoblast migration (GO:0051451)2.72801523
108interferon-gamma secretion (GO:0072643)2.72096027
109cellular response to antibiotic (GO:0071236)2.71097439
110regulation of RIG-I signaling pathway (GO:0039535)2.70746598
111negative regulation of protein oligomerization (GO:0032460)2.69297019
112glandular epithelial cell development (GO:0002068)2.67727743
113cellular response to toxic substance (GO:0097237)2.67439132
114regulation of lamellipodium organization (GO:1902743)2.65184458
115face development (GO:0060324)2.64285852
116cytidine deamination (GO:0009972)2.63809288
117cytidine metabolic process (GO:0046087)2.63809288
118cytidine catabolic process (GO:0006216)2.63809288
119sulfur amino acid catabolic process (GO:0000098)2.63054610
120megakaryocyte development (GO:0035855)2.62799500
121negative regulation of telomere maintenance (GO:0032205)2.61354299
122piRNA metabolic process (GO:0034587)2.61349573
123macroautophagy (GO:0016236)2.61308177
124neuronal action potential (GO:0019228)2.60932726
125hypotonic response (GO:0006971)2.60105422
126ubiquinone biosynthetic process (GO:0006744)2.59505032
127NAD biosynthetic process (GO:0009435)2.59112823
128glycerol ether metabolic process (GO:0006662)2.58950409
1293-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.58614574
130purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.58614574
131antigen processing and presentation of endogenous antigen (GO:0019883)2.58405132
132DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.57550609
133photoreceptor cell maintenance (GO:0045494)2.55934755
134respiratory chain complex IV assembly (GO:0008535)2.55801635
135basic amino acid transport (GO:0015802)2.55517880
136signal peptide processing (GO:0006465)2.55441252
137regulation of Cdc42 GTPase activity (GO:0043088)2.55072248
138regulation of action potential (GO:0098900)2.54716484
139transcytosis (GO:0045056)2.53800735
140phosphatidylcholine acyl-chain remodeling (GO:0036151)2.53103308
141rRNA catabolic process (GO:0016075)2.53044478
142negative regulation of synaptic transmission, GABAergic (GO:0032229)2.52342628
143protein polyglutamylation (GO:0018095)2.51851147
144thyroid hormone metabolic process (GO:0042403)2.51653347
145ubiquinone metabolic process (GO:0006743)2.51306151
146negative regulation of cytosolic calcium ion concentration (GO:0051481)2.50290080
147nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.50011300
148alkaloid metabolic process (GO:0009820)2.49553599
149positive regulation of defense response to virus by host (GO:0002230)2.49283449
150neural tube formation (GO:0001841)2.48831292
151regulation of cilium movement (GO:0003352)2.48768050
152regulation of keratinocyte differentiation (GO:0045616)2.47712295
153cilium morphogenesis (GO:0060271)2.47672374
154pyrimidine-containing compound transmembrane transport (GO:0072531)2.47352019
155toxin transport (GO:1901998)2.47325099
156endosome to melanosome transport (GO:0035646)2.46514010
157endosome to pigment granule transport (GO:0043485)2.46514010
158mitotic G1/S transition checkpoint (GO:0044819)2.46455365
159negative regulation of cell cycle arrest (GO:0071157)2.45857703
160multicellular organism reproduction (GO:0032504)2.45374192
161response to pheromone (GO:0019236)2.43575220
162segment specification (GO:0007379)2.43555696
163reflex (GO:0060004)2.42984950
164polarized epithelial cell differentiation (GO:0030859)2.42797721
165negative regulation of actin filament bundle assembly (GO:0032232)2.42610858
166embryonic eye morphogenesis (GO:0048048)2.42325324
167regulation of mitochondrial depolarization (GO:0051900)2.41838027
168negative regulation of interleukin-1 production (GO:0032692)2.40649742
169nephron tubule morphogenesis (GO:0072078)2.39251540
170nephron epithelium morphogenesis (GO:0072088)2.39251540
171GPI anchor metabolic process (GO:0006505)2.38818531
172axonemal dynein complex assembly (GO:0070286)2.38028586
173positive regulation of oligodendrocyte differentiation (GO:0048714)2.34779924
174neurotransmitter metabolic process (GO:0042133)2.33828273
175parturition (GO:0007567)2.32812272
176cilium organization (GO:0044782)2.30679811
177auditory receptor cell stereocilium organization (GO:0060088)2.30229699
178exogenous drug catabolic process (GO:0042738)2.30187464
179cytochrome complex assembly (GO:0017004)2.29282886
180positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.29168460
181regulation of mesoderm development (GO:2000380)2.28846666
182regulation of rhodopsin mediated signaling pathway (GO:0022400)2.28334023
183synaptic transmission, cholinergic (GO:0007271)2.27830153
184regulation of hippo signaling (GO:0035330)2.26871109
185cellular biogenic amine catabolic process (GO:0042402)2.26811710
186amine catabolic process (GO:0009310)2.26811710
187drug catabolic process (GO:0042737)2.24538225
188pyrimidine ribonucleoside catabolic process (GO:0046133)2.24516577
189retinal cone cell development (GO:0046549)2.23484422
190quinone biosynthetic process (GO:1901663)2.23461049
191positive regulation of fatty acid transport (GO:2000193)2.23029422
192DNA methylation involved in gamete generation (GO:0043046)2.22688814
193protein complex biogenesis (GO:0070271)2.21928620

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.79058329
2STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.28597562
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.19178584
4VDR_22108803_ChIP-Seq_LS180_Human2.99179176
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.72529919
6GBX2_23144817_ChIP-Seq_PC3_Human2.65103669
7STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.48005030
8SOX2_27498859_Chip-Seq_STOMACH_Mouse2.47134207
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33272573
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.31271029
11ZNF263_19887448_ChIP-Seq_K562_Human2.27684925
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.26639267
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.19692949
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18440410
15ESR1_21235772_ChIP-Seq_MCF-7_Human2.15057678
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.11487713
17* CDX2_20551321_ChIP-Seq_CACO-2_Human2.10427527
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.03460604
19EZH2_22144423_ChIP-Seq_EOC_Human2.02238044
20GATA2_21666600_ChIP-Seq_HMVEC_Human1.99330372
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.99153536
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.98111040
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.90518950
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.90185574
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.90173711
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89735879
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87917913
28* SOX2_20726797_ChIP-Seq_SW620_Human1.87804141
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87320806
30SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.84522321
31ER_23166858_ChIP-Seq_MCF-7_Human1.83428158
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82313439
33PU.1_20513432_ChIP-Seq_Bcells_Mouse1.80828645
34VDR_21846776_ChIP-Seq_THP-1_Human1.79160237
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.78127787
36SCL_19346495_ChIP-Seq_HPC-7_Human1.77127307
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75608861
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.75175905
39TAF15_26573619_Chip-Seq_HEK293_Human1.74941064
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.74459140
41IGF1R_20145208_ChIP-Seq_DFB_Human1.71020169
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.68463640
43* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68392775
44MYC_22102868_ChIP-Seq_BL_Human1.67317381
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.66807304
46P300_19829295_ChIP-Seq_ESCs_Human1.66577670
47* RUNX1_27514584_Chip-Seq_MCF-7_Human1.65512813
48GATA6_25053715_ChIP-Seq_YYC3_Human1.62622371
49RACK7_27058665_Chip-Seq_MCF-7_Human1.62552273
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62085928
51BCAT_22108803_ChIP-Seq_LS180_Human1.58891131
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58496750
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57456386
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55533208
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54411912
56TP53_22573176_ChIP-Seq_HFKS_Human1.53686379
57EWS_26573619_Chip-Seq_HEK293_Human1.52607143
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.52230562
59GATA1_22383799_ChIP-Seq_G1ME_Mouse1.51247464
60REST_21632747_ChIP-Seq_MESCs_Mouse1.50982082
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48219554
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47659504
63* GATA4_25053715_ChIP-Seq_YYC3_Human1.47619333
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.47278308
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47278308
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.46609521
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.45112967
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44220878
69AR_25329375_ChIP-Seq_VCAP_Human1.43405382
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.41876997
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40955250
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40096577
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39359816
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.38213640
75FUS_26573619_Chip-Seq_HEK293_Human1.37316897
76STAT3_23295773_ChIP-Seq_U87_Human1.37230165
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37176765
78DROSHA_22980978_ChIP-Seq_HELA_Human1.36890778
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35947280
80SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35247729
81SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34862913
82IRF1_19129219_ChIP-ChIP_H3396_Human1.33922923
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33324017
84AR_20517297_ChIP-Seq_VCAP_Human1.33296305
85GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.33231581
86ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32734749
87TCF4_23295773_ChIP-Seq_U87_Human1.32101428
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.30684628
89* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30382973
90GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29408355
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29158412
92* TCF4_22108803_ChIP-Seq_LS180_Human1.28881529
93SMAD4_21799915_ChIP-Seq_A2780_Human1.28780442
94NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26803731
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26802137
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26703206
97TCF7_22412390_ChIP-Seq_EML_Mouse1.26530847
98VDR_24763502_ChIP-Seq_THP-1_Human1.26062327
99NOTCH1_21737748_ChIP-Seq_TLL_Human1.25934754
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25906423
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25906423
102CBP_20019798_ChIP-Seq_JUKART_Human1.25795416
103IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25795416
104EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25600400
105FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25276630
106KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.24792307
107KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.24792307
108KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.24792307
109HOXB7_26014856_ChIP-Seq_BT474_Human1.24370362
110PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22722239
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22564448
112ETS1_21867929_ChIP-Seq_TH2_Mouse1.22548067
113DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22395718
114PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.22196322
115ATF3_27146783_Chip-Seq_COLON_Human1.21404168
116SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21234283
117CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21148532
118NANOG_19829295_ChIP-Seq_ESCs_Human1.21086656
119SOX2_19829295_ChIP-Seq_ESCs_Human1.21086656
120RUNX2_22187159_ChIP-Seq_PCA_Human1.20646394
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20616901
122PRDM14_20953172_ChIP-Seq_ESCs_Human1.20602088
123HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19159029
124NCOR_22424771_ChIP-Seq_293T_Human1.17392682
125FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16229023
126LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15607575
127ARNT_22903824_ChIP-Seq_MCF-7_Human1.15101001
128CBX2_27304074_Chip-Seq_ESCs_Mouse1.14890119
129MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14436547
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.14166622
131PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13536622
132* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13162227
133SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13052149
134FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.12454554
135RUNX1_22412390_ChIP-Seq_EML_Mouse1.11720021
136GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11706480
137PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11361755
138CHD1_26751641_Chip-Seq_LNCaP_Human1.11225255
139GATA1_22025678_ChIP-Seq_K562_Human1.11187141
140SMAD4_21741376_ChIP-Seq_EPCs_Human1.10929523
141TCF3_18692474_ChIP-Seq_MESCs_Mouse1.10092060
142ERA_21632823_ChIP-Seq_H3396_Human1.09992017
143PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08530974
144* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.08486810
145NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.08424933
146FOXH1_21741376_ChIP-Seq_EPCs_Human1.08164443
147GATA3_24758297_ChIP-Seq_MCF-7_Human1.08086635
148SMAD_19615063_ChIP-ChIP_OVARY_Human1.07950565
149NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.07870891
150TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07643837
151NFE2_27457419_Chip-Seq_LIVER_Mouse1.07552698
152TAF2_19829295_ChIP-Seq_ESCs_Human1.06473001
153ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06349202
154KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05531147
155AHR_22903824_ChIP-Seq_MCF-7_Human1.05530835
156ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05186683
157* CDX2_22108803_ChIP-Seq_LS180_Human1.04834034
158NANOG_20526341_ChIP-Seq_ESCs_Human1.04199829
159FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04018342
160MYB_26560356_Chip-Seq_TH2_Human1.03456170
161SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03028141
162IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02992048
163KAP1_27257070_Chip-Seq_ESCs_Mouse1.02918325
164SMAD3_21741376_ChIP-Seq_EPCs_Human1.02673947
165EZH2_27294783_Chip-Seq_NPCs_Mouse1.02348237
166TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.01326084
167LXR_22292898_ChIP-Seq_THP-1_Human1.01052604
168AR_21572438_ChIP-Seq_LNCaP_Human1.01003532
169RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00600677
170KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00531944
171RNF2_27304074_Chip-Seq_NSC_Mouse0.99593809
172NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99527052
173SPI1_26923725_Chip-Seq_HPCs_Mouse0.98652454
174FLI1_21867929_ChIP-Seq_TH2_Mouse0.98319281
175EZH2_27294783_Chip-Seq_ESCs_Mouse0.98161927
176GATA3_26560356_Chip-Seq_TH2_Human0.97816969
177SALL1_21062744_ChIP-ChIP_HESCs_Human0.97647808
178PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97601593
179* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97470880
180FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.96874431
181HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96717078
182SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95815541
183* MYC_19829295_ChIP-Seq_ESCs_Human0.94841882
184ELK3_25401928_ChIP-Seq_HUVEC_Human0.94769900
185KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94744670
186FOXH1_21741376_ChIP-Seq_ESCs_Human0.94581823
187MYB_26560356_Chip-Seq_TH1_Human0.94024476
188KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93855401
189CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.93414818
190OCT1_27270436_Chip-Seq_PROSTATE_Human0.93258304
191PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.93047969
192MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92509165
193GATA1_19941827_ChIP-Seq_MEL_Mouse0.92349205
194ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92338653
195SPI1_23547873_ChIP-Seq_NB4_Human0.92224445
196TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91786830

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu4.23830739
2MP0002009_preneoplasia4.11498383
3MP0001873_stomach_inflammation3.92418087
4MP0010234_abnormal_vibrissa_follicle3.82254166
5MP0003195_calcinosis3.46502694
6MP0008004_abnormal_stomach_pH3.08744704
7MP0005310_abnormal_salivary_gland2.84844443
8MP0002166_altered_tumor_susceptibility2.62619495
9MP0009278_abnormal_bone_marrow2.59591518
10MP0008875_abnormal_xenobiotic_pharmacok2.56247300
11MP0000490_abnormal_crypts_of2.54126410
12MP0002653_abnormal_ependyma_morphology2.53913805
13MP0008877_abnormal_DNA_methylation2.43485929
14MP0002876_abnormal_thyroid_physiology2.41052267
15MP0004043_abnormal_pH_regulation2.34813776
16MP0005551_abnormal_eye_electrophysiolog2.31119767
17MP0003724_increased_susceptibility_to2.25516188
18MP0001968_abnormal_touch/_nociception2.23473699
19MP0004885_abnormal_endolymph2.18114055
20MP0002006_tumorigenesis2.12760902
21MP0005397_hematopoietic_system_phenotyp2.10560417
22MP0001545_abnormal_hematopoietic_system2.10560417
23MP0002102_abnormal_ear_morphology2.10461009
24MP0002396_abnormal_hematopoietic_system2.10051339
25MP0006054_spinal_hemorrhage2.07970404
26MP0003787_abnormal_imprinting2.07527183
27MP0000569_abnormal_digit_pigmentation2.06858700
28MP0008872_abnormal_physiological_respon2.02631275
29MP0003718_maternal_effect2.01659234
30MP0010155_abnormal_intestine_physiology1.96956150
31MP0009745_abnormal_behavioral_response1.96881137
32MP0002638_abnormal_pupillary_reflex1.96733599
33MP0002877_abnormal_melanocyte_morpholog1.96539671
34MP0000427_abnormal_hair_cycle1.96129094
35MP0001501_abnormal_sleep_pattern1.94779265
36MP0003866_abnormal_defecation1.92754744
37MP0003011_delayed_dark_adaptation1.91101329
38MP0002277_abnormal_respiratory_mucosa1.90714421
39MP0005085_abnormal_gallbladder_physiolo1.88388837
40MP0010368_abnormal_lymphatic_system1.88002612
41MP0004133_heterotaxia1.85993592
42MP0009046_muscle_twitch1.78130551
43MP0005377_hearing/vestibular/ear_phenot1.76871242
44MP0003878_abnormal_ear_physiology1.76871242
45MP0003300_gastrointestinal_ulcer1.75707651
46MP0000613_abnormal_salivary_gland1.72542562
47MP0000470_abnormal_stomach_morphology1.69515357
48MP0001485_abnormal_pinna_reflex1.68327172
49MP0008995_early_reproductive_senescence1.63451266
50MP0001666_abnormal_nutrient_absorption1.63251860
51MP0000462_abnormal_digestive_system1.62091985
52MP0002138_abnormal_hepatobiliary_system1.61659819
53MP0001849_ear_inflammation1.59736574
54MP0005174_abnormal_tail_pigmentation1.58982445
55MP0002736_abnormal_nociception_after1.57917732
56MP0004233_abnormal_muscle_weight1.57757385
57MP0002272_abnormal_nervous_system1.56058723
58MP0003453_abnormal_keratinocyte_physiol1.55571280
59MP0005220_abnormal_exocrine_pancreas1.51849919
60MP0005167_abnormal_blood-brain_barrier1.50426104
61MP0001663_abnormal_digestive_system1.49533287
62MP0004808_abnormal_hematopoietic_stem1.46441750
63MP0005464_abnormal_platelet_physiology1.45038523
64MP0004142_abnormal_muscle_tone1.43595327
65MP0003943_abnormal_hepatobiliary_system1.39858837
66MP0002796_impaired_skin_barrier1.39639568
67MP0002928_abnormal_bile_duct1.38567367
68MP0005381_digestive/alimentary_phenotyp1.37877079
69MP0001486_abnormal_startle_reflex1.37824519
70MP0002909_abnormal_adrenal_gland1.37558594
71MP0005253_abnormal_eye_physiology1.37539250
72MP0002249_abnormal_larynx_morphology1.35575289
73MP0006276_abnormal_autonomic_nervous1.35456963
74MP0000685_abnormal_immune_system1.35280172
75MP0002064_seizures1.35110422
76MP0002837_dystrophic_cardiac_calcinosis1.33025860
77MP0005645_abnormal_hypothalamus_physiol1.31905267
78MP0005058_abnormal_lysosome_morphology1.31899027
79MP0005171_absent_coat_pigmentation1.31559959
80MP0003828_pulmonary_edema1.30438028
81MP0003646_muscle_fatigue1.29769915
82MP0002733_abnormal_thermal_nociception1.28146903
83MP0001881_abnormal_mammary_gland1.26445885
84MP0000639_abnormal_adrenal_gland1.26060919
85MP0002572_abnormal_emotion/affect_behav1.24617789
86MP0005365_abnormal_bile_salt1.24617727
87MP0000631_abnormal_neuroendocrine_gland1.21928400
88MP0000383_abnormal_hair_follicle1.21865254
89MP0000477_abnormal_intestine_morphology1.21037038
90MP0001970_abnormal_pain_threshold1.20269516
91MP0000681_abnormal_thyroid_gland1.20218438
92MP0003172_abnormal_lysosome_physiology1.18983858
93MP0001664_abnormal_digestion1.18881199
94MP0005075_abnormal_melanosome_morpholog1.15598504
95MP0000579_abnormal_nail_morphology1.15119454
96MP0005389_reproductive_system_phenotype1.14923617
97MP0000230_abnormal_systemic_arterial1.14775685
98MP0003136_yellow_coat_color1.13201420
99MP0001919_abnormal_reproductive_system1.13151302
100MP0004924_abnormal_behavior1.12408761
101MP0005386_behavior/neurological_phenoty1.12408761
102MP0004742_abnormal_vestibular_system1.11932933
103MP0010329_abnormal_lipoprotein_level1.11900422
104MP0003763_abnormal_thymus_physiology1.11631038
105MP0002735_abnormal_chemical_nociception1.11426050
106MP0003045_fibrosis1.09297012
107MP0002557_abnormal_social/conspecific_i1.06276427
108MP0001765_abnormal_ion_homeostasis1.06217682
109MP0009764_decreased_sensitivity_to1.02789557
110MP0001905_abnormal_dopamine_level1.02674407
111MP0003566_abnormal_cell_adhesion1.02570336
112MP0003252_abnormal_bile_duct1.01549513
113MP0005165_increased_susceptibility_to1.00350885
114MP0004019_abnormal_vitamin_homeostasis0.97979801
115MP0000538_abnormal_urinary_bladder0.96562188
116MP0010386_abnormal_urinary_bladder0.96294175
117MP0003638_abnormal_response/metabolism_0.95234546
118MP0001502_abnormal_circadian_rhythm0.95157700
119MP0003880_abnormal_central_pattern0.95046257
120MP0001879_abnormal_lymphatic_vessel0.94915158
121MP0004145_abnormal_muscle_electrophysio0.94151585
122MP0003699_abnormal_female_reproductive0.93840953
123MP0003879_abnormal_hair_cell0.91350691
124MP0005367_renal/urinary_system_phenotyp0.91100230
125MP0000516_abnormal_urinary_system0.91100230
126MP0003635_abnormal_synaptic_transmissio0.90863948
127MP0002067_abnormal_sensory_capabilities0.90168568
128MP0002229_neurodegeneration0.89507363
129MP0002160_abnormal_reproductive_system0.89215976
130MP0002063_abnormal_learning/memory/cond0.88908252
131MP0005636_abnormal_mineral_homeostasis0.88669677
132MP0001986_abnormal_taste_sensitivity0.88166663
133MP0005448_abnormal_energy_balance0.87925605
134MP0005084_abnormal_gallbladder_morpholo0.87270694
135MP0002405_respiratory_system_inflammati0.86880590
136MP0010352_gastrointestinal_tract_polyps0.86839929
137MP0002086_abnormal_extraembryonic_tissu0.86630900
138MP0004782_abnormal_surfactant_physiolog0.85366642
139MP0005332_abnormal_amino_acid0.84826562
140MP0005195_abnormal_posterior_eye0.84383323
141MP0001756_abnormal_urination0.84109491
142MP0004947_skin_inflammation0.83903264
143MP0000465_gastrointestinal_hemorrhage0.83576946
144MP0001944_abnormal_pancreas_morphology0.83526086
145MP0003119_abnormal_digestive_system0.83264624
146MP0006292_abnormal_olfactory_placode0.83103441
147MP0000678_abnormal_parathyroid_gland0.82786714
148MP0003567_abnormal_fetal_cardiomyocyte0.81994307
149MP0005647_abnormal_sex_gland0.81391518
150MP0002019_abnormal_tumor_incidence0.81043553
151MP0005395_other_phenotype0.81023115
152MP0001324_abnormal_eye_pigmentation0.80012066
153MP0002060_abnormal_skin_morphology0.79901599
154MP0002282_abnormal_trachea_morphology0.78755157
155MP0006072_abnormal_retinal_apoptosis0.77220216
156MP0001835_abnormal_antigen_presentation0.77173872
157MP0001348_abnormal_lacrimal_gland0.76712163
158MP0004484_altered_response_of0.75799292
159MP0003183_abnormal_peptide_metabolism0.74647818
160MP0005646_abnormal_pituitary_gland0.74581201
161MP0001845_abnormal_inflammatory_respons0.74412731
162MP0002254_reproductive_system_inflammat0.73911107
163MP0001764_abnormal_homeostasis0.73415225
164MP0002132_abnormal_respiratory_system0.73207276
165MP0003122_maternal_imprinting0.73005764
166MP0003283_abnormal_digestive_organ0.72697291
167MP0001119_abnormal_female_reproductive0.72470268
168MP0005671_abnormal_response_to0.71811464
169MP0004147_increased_porphyrin_level0.70329250
170MP0009780_abnormal_chondrocyte_physiolo0.69137319
171MP0004957_abnormal_blastocyst_morpholog0.68141303
172MP0002693_abnormal_pancreas_physiology0.68024798
173MP0000627_abnormal_mammary_gland0.65760345
174MP0002398_abnormal_bone_marrow0.64952097
175MP0002098_abnormal_vibrissa_morphology0.64248757
176MP0001697_abnormal_embryo_size0.63279564
177MP0003941_abnormal_skin_development0.62981717
178MP0000343_altered_response_to0.62751141
179MP0000689_abnormal_spleen_morphology0.62368276
180MP0009785_altered_susceptibility_to0.62256445
181MP0003786_premature_aging0.61251033
182MP0005501_abnormal_skin_physiology0.60971226

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.55633910
2Urinary glycosaminoglycan excretion (HP:0003541)4.31975439
3Mucopolysacchariduria (HP:0008155)4.31975439
4True hermaphroditism (HP:0010459)4.24617123
5Abnormality of midbrain morphology (HP:0002418)4.23740120
6Molar tooth sign on MRI (HP:0002419)4.23740120
7Pustule (HP:0200039)4.19645013
8Male infertility (HP:0003251)4.15900200
9Congenital stationary night blindness (HP:0007642)4.12781506
10Abnormality of polysaccharide metabolism (HP:0011012)4.04666064
11Abnormality of glycosaminoglycan metabolism (HP:0004371)4.04666064
12Abnormality of mucopolysaccharide metabolism (HP:0011020)4.04666064
13Pancreatic fibrosis (HP:0100732)4.00333076
14Annular pancreas (HP:0001734)3.99611727
15Lip pit (HP:0100267)3.89597586
16Thrombocytosis (HP:0001894)3.87493218
17Nephronophthisis (HP:0000090)3.55554159
18Dysostosis multiplex (HP:0000943)3.52682458
19Abnormality of the renal cortex (HP:0011035)3.39117743
20Abnormality of the renal medulla (HP:0100957)3.20636048
21Hyperventilation (HP:0002883)3.19237079
22Type II lissencephaly (HP:0007260)3.14089910
23Decreased circulating renin level (HP:0003351)3.06654506
24Poikiloderma (HP:0001029)3.05969810
25Right ventricular cardiomyopathy (HP:0011663)3.02898900
26Vacuolated lymphocytes (HP:0001922)2.96747396
27Attenuation of retinal blood vessels (HP:0007843)2.96495770
28Type 2 muscle fiber atrophy (HP:0003554)2.96041224
29Abnormal hemoglobin (HP:0011902)2.92363557
30Tubular atrophy (HP:0000092)2.90564725
31Pili torti (HP:0003777)2.90305333
32Milia (HP:0001056)2.85349333
33Abolished electroretinogram (ERG) (HP:0000550)2.84442132
34Cystic liver disease (HP:0006706)2.82831842
35Aplastic anemia (HP:0001915)2.82376179
36Abnormal rod and cone electroretinograms (HP:0008323)2.82013263
37Alopecia of scalp (HP:0002293)2.81530488
38Dynein arm defect of respiratory motile cilia (HP:0012255)2.80205349
39Absent/shortened dynein arms (HP:0200106)2.80205349
40Abnormality of male internal genitalia (HP:0000022)2.80143644
41Muscle fiber atrophy (HP:0100295)2.78785388
42Vertebral hypoplasia (HP:0008417)2.75179887
43Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.75179887
44Abnormal drinking behavior (HP:0030082)2.74468526
45Polydipsia (HP:0001959)2.74468526
46Inability to walk (HP:0002540)2.73811285
47Concave nail (HP:0001598)2.71102203
48Decreased central vision (HP:0007663)2.71002810
49Growth hormone excess (HP:0000845)2.70706448
50Acute myeloid leukemia (HP:0004808)2.70173815
51Stomatitis (HP:0010280)2.69553472
52Medial flaring of the eyebrow (HP:0010747)2.67206339
53Exocrine pancreatic insufficiency (HP:0001738)2.65193044
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.63585257
55Abnormality of alanine metabolism (HP:0010916)2.63585257
56Hyperalaninemia (HP:0003348)2.63585257
57Pendular nystagmus (HP:0012043)2.60465861
58Shawl scrotum (HP:0000049)2.59032942
59Hypothermia (HP:0002045)2.57927956
60Onycholysis (HP:0001806)2.57813006
61Congenital, generalized hypertrichosis (HP:0004540)2.55888702
62Facial hemangioma (HP:0000329)2.55652059
63Chronic hepatic failure (HP:0100626)2.55505163
64IgA deficiency (HP:0002720)2.51740508
65Abnormal respiratory motile cilium morphology (HP:0005938)2.50868137
66Abnormal respiratory epithelium morphology (HP:0012253)2.50868137
67Absent rod-and cone-mediated responses on ERG (HP:0007688)2.47243874
68Nonprogressive disorder (HP:0003680)2.47170427
69Furrowed tongue (HP:0000221)2.46171610
70Progressive inability to walk (HP:0002505)2.44248370
71Easy fatigability (HP:0003388)2.43745399
72Fatigue (HP:0012378)2.40280969
73Stomach cancer (HP:0012126)2.40181287
74Premature skin wrinkling (HP:0100678)2.40020931
75Clumsiness (HP:0002312)2.38175399
76Genetic anticipation (HP:0003743)2.37999373
77Decreased electroretinogram (ERG) amplitude (HP:0000654)2.37957828
78Cheilitis (HP:0100825)2.35460516
79Hypoplasia of the pons (HP:0012110)2.34233648
80Abnormality of the neuromuscular junction (HP:0003398)2.30662264
81Fatigable weakness (HP:0003473)2.30662264
82Tongue fasciculations (HP:0001308)2.29966628
83Progressive neurologic deterioration (HP:0002344)2.29868575
84Male pseudohermaphroditism (HP:0000037)2.29095406
85Abnormality of the fingertips (HP:0001211)2.28769534
86Gaze-evoked nystagmus (HP:0000640)2.27299866
87Abnormality of renin-angiotensin system (HP:0000847)2.26136103
88Progressive cerebellar ataxia (HP:0002073)2.26007301
89Polycythemia (HP:0001901)2.25495182
90Sclerocornea (HP:0000647)2.25260486
91Increased corneal curvature (HP:0100692)2.23266870
92Keratoconus (HP:0000563)2.23266870
93Hypoplasia of the uterus (HP:0000013)2.22249758
94Large for gestational age (HP:0001520)2.21938009
95Abnormality of the nasal mucosa (HP:0000433)2.21721122
96Joint stiffness (HP:0001387)2.19222408
97Hypoplasia of the ulna (HP:0003022)2.18245996
98Congenital hip dislocation (HP:0001374)2.17339549
99Abnormal number of erythroid precursors (HP:0012131)2.17334016
100Capillary hemangiomas (HP:0005306)2.16507761
101Reduced antithrombin III activity (HP:0001976)2.16406915
102Intestinal atresia (HP:0011100)2.16388016
103Albinism (HP:0001022)2.15981637
104Type I transferrin isoform profile (HP:0003642)2.15637623
105Ketosis (HP:0001946)2.13843994
106Muscle fibrillation (HP:0010546)2.13713416
107Ketoacidosis (HP:0001993)2.13585966
108Amelogenesis imperfecta (HP:0000705)2.13167275
109Renal cortical cysts (HP:0000803)2.12486320
110Bile duct proliferation (HP:0001408)2.12427192
111Abnormal biliary tract physiology (HP:0012439)2.12427192
112Abnormality of cochlea (HP:0000375)2.12361051
113Polyuria (HP:0000103)2.12322805
114Congenital sensorineural hearing impairment (HP:0008527)2.11967716
115Short humerus (HP:0005792)2.11814364
116Aplasia/Hypoplasia of the sacrum (HP:0008517)2.11067657
117Congenital hepatic fibrosis (HP:0002612)2.11003775
118Abnormality of the gastric mucosa (HP:0004295)2.10516342
119Abnormal ciliary motility (HP:0012262)2.09876749
120Gait imbalance (HP:0002141)2.07473963
121Agitation (HP:0000713)2.06935496
122Hypergonadotropic hypogonadism (HP:0000815)2.06520146
123Lissencephaly (HP:0001339)2.06392697
124Aplasia/Hypoplasia of the tongue (HP:0010295)2.05953943
125Short chin (HP:0000331)2.03727476
126Broad-based gait (HP:0002136)2.03672019
127Severe muscular hypotonia (HP:0006829)2.03141162
128Intestinal fistula (HP:0100819)2.02682289
129Interstitial pulmonary disease (HP:0006530)2.01783037
130Plantar hyperkeratosis (HP:0007556)1.99821086
131Abnormal albumin level (HP:0012116)1.99724399
132Hypoalbuminemia (HP:0003073)1.99724399
133Hypokinesia (HP:0002375)1.97330297
134Beaking of vertebral bodies (HP:0004568)1.95870671
135Ureteral stenosis (HP:0000071)1.95832350
136Aplasia/Hypoplasia of the tibia (HP:0005772)1.95799017
137Bowing of the arm (HP:0006488)1.95670858
138Bowed forearm bones (HP:0003956)1.95670858
139Congenital primary aphakia (HP:0007707)1.95469678
140Asymmetric septal hypertrophy (HP:0001670)1.94819953
141Retrobulbar optic neuritis (HP:0100654)1.94818527
142Optic neuritis (HP:0100653)1.94818527
143Myositis (HP:0100614)1.94226291
144Abnormality of the pons (HP:0007361)1.94087651
145Hypomagnesemia (HP:0002917)1.92812408
146Anencephaly (HP:0002323)1.92721303
147Volvulus (HP:0002580)1.92481110
148Aplasia/hypoplasia of the uterus (HP:0008684)1.92326296
149Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.92012380
150Oligodontia (HP:0000677)1.92004341
151Occipital encephalocele (HP:0002085)1.91993417
152Pigmentary retinal degeneration (HP:0001146)1.90188674
153Hypotrichosis (HP:0001006)1.89990159
154Bony spicule pigmentary retinopathy (HP:0007737)1.89563615
155Vaginal fistula (HP:0004320)1.88848708
1563-Methylglutaconic aciduria (HP:0003535)1.88275355
157Adactyly (HP:0009776)1.88271158
158Hyperparathyroidism (HP:0000843)1.88005181
159Elevated erythrocyte sedimentation rate (HP:0003565)1.87914592
160Chorioretinal atrophy (HP:0000533)1.87695033
161Papillary thyroid carcinoma (HP:0002895)1.87080745
162Orchitis (HP:0100796)1.86884945
163Progressive muscle weakness (HP:0003323)1.86423801
164Increased IgM level (HP:0003496)1.84762352
165Nasal polyposis (HP:0100582)1.84496989
166Abnormal respiratory motile cilium physiology (HP:0012261)1.84396916
167Ureteral obstruction (HP:0006000)1.83734260
168Hemiparesis (HP:0001269)1.83427585
169Infertility (HP:0000789)1.80900928
170Colitis (HP:0002583)1.80752541
171Aplasia/Hypoplasia of the ulna (HP:0006495)1.80070136
172Tachypnea (HP:0002789)1.79948660
173Aplasia/hypoplasia of the humerus (HP:0006507)1.79530451
174Nephrogenic diabetes insipidus (HP:0009806)1.79517247
175Rectal fistula (HP:0100590)1.78374314
176Rectovaginal fistula (HP:0000143)1.78374314
177Absent speech (HP:0001344)1.78148539
178Abnormality of the intrinsic pathway (HP:0010989)1.78087938
179Febrile seizures (HP:0002373)1.77738662
180Fair hair (HP:0002286)1.77298666
181Abnormality of T cell physiology (HP:0011840)1.77165103
182Abnormality of renal excretion (HP:0011036)1.76830272
183Bifid uvula (HP:0000193)1.76153351
184Protruding tongue (HP:0010808)1.75753015
185Coarse hair (HP:0002208)1.74581907
186Mesangial abnormality (HP:0001966)1.74171690
187Progressive hearing impairment (HP:0001730)1.74027426
188Sparse lateral eyebrow (HP:0005338)1.73529923
189Rib fusion (HP:0000902)1.72783044
190Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.71905916
191Postaxial foot polydactyly (HP:0001830)1.71069211
192Metabolic alkalosis (HP:0200114)1.70819725
193Abnormal urine output (HP:0012590)1.69142450
194Macular degeneration (HP:0000608)1.68425849
195Generalized hypopigmentation of hair (HP:0011358)1.66268592
196Hyperaldosteronism (HP:0000859)1.66236701

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K64.18311798
2AKT33.68134353
3MAPK153.67477621
4MATK3.60091934
5ADRBK23.42886935
6BMPR1B3.31370680
7TAOK33.18859178
8LATS12.83618956
9GRK12.66832169
10WNK42.62828618
11DAPK22.40028662
12TRPM72.35312526
13EEF2K2.35002462
14MAPKAPK32.32160864
15PINK12.20649350
16OXSR12.18081671
17TLK12.16116442
18DAPK12.15448455
19MAP3K112.07930537
20WNK32.02553669
21DDR22.01613952
22TIE11.91362624
23ICK1.78611830
24TAOK11.76474302
25ERN11.74889305
26MUSK1.71126220
27MST41.69890269
28ZAK1.69564437
29CASK1.69429484
30MAP4K21.67051501
31MAPK131.62762360
32TNK21.62226478
33TXK1.59509633
34MAP3K121.58285304
35STK391.56642380
36RPS6KB21.54975388
37EPHA21.47852876
38CDK191.45467137
39ADRBK11.44965945
40MYLK1.42662832
41SIK11.35963346
42PAK31.35867459
43PRKD21.34636112
44IRAK11.34592094
45CAMKK21.33149746
46FLT31.32560873
47FRK1.29070335
48PTK2B1.27445259
49HIPK21.25541309
50LATS21.24804396
51RIPK11.20109876
52CDK81.18499187
53DYRK1B1.15004506
54TGFBR21.05585013
55PRKCE1.02381136
56RAF11.01720056
57TYRO30.96841510
58LMTK20.96461969
59BCKDK0.95447626
60DMPK0.94840265
61CSK0.94075087
62CDK60.93894559
63PRKAA20.93748219
64IRAK40.93674047
65FGR0.93435993
66KIT0.90613761
67PIM20.89834097
68PHKG10.89588474
69PHKG20.89588474
70BMX0.88795081
71STK38L0.88684799
72NTRK30.85099166
73PRKG20.82878795
74MAPKAPK50.82580659
75CHUK0.79985371
76STK30.78653098
77YES10.78387249
78PIM10.76476392
79EPHB10.75358793
80MAP3K40.75061914
81PRKCG0.74529195
82DYRK20.73814005
83JAK30.73337717
84NUAK10.73243622
85STK100.69825888
86FES0.68292648
87IKBKE0.67473476
88CDK70.66895263
89MAP3K90.66882040
90TGFBR10.66751033
91IKBKB0.66304939
92PIK3CA0.65984608
93PRKCI0.65590694
94GRK60.63737369
95KSR20.63590804
96MAP2K30.63470716
97MAPK110.63420218
98MAP4K10.63192613
99STK110.63072134
100KDR0.62478095
101PDGFRA0.62079955
102INSRR0.62013722
103STK240.61824591
104TEC0.61512058
105NLK0.59102943
106ITK0.58704805
107PNCK0.58619881
108PRKCZ0.58313700
109PRKCQ0.57952853
110CSNK1G20.56414244
111PIK3CG0.55689583
112ERBB40.55515623
113PRKAA10.55282985
114STK380.54798463
115CAMK10.54507143
116FER0.52923128
117CAMKK10.52416319
118CSNK1G10.51970764
119EPHA30.51580005
120JAK20.51054788
121RPS6KL10.50308728
122RPS6KC10.50308728
123PAK40.50265935
124BRSK20.48458227
125BTK0.48223583
126ZAP700.47522314
127CSNK1G30.47518384
128CAMK1D0.47262416
129MARK10.46629784
130RPS6KA60.46071651
131FGFR20.45605463
132MAP2K70.43647296
133CAMK2A0.43102592
134SIK20.42828290
135RPS6KB10.41694539
136RPS6KA10.41281240
137PRKACA0.41213357
138RIPK40.41055914
139LRRK20.40994952
140MAP2K10.40532191
141MAP3K10.40055669
142PKN20.39849361
143RPS6KA50.39767983
144LYN0.38773691
145PTK20.38534319
146EPHA40.38086431
147CDC42BPA0.37774340
148WNK10.36760726
149CSNK1A10.36499102
150MAP2K40.36345628
151PDK10.35496190
152PRKCA0.35181778
153GRK50.34836247
154SCYL20.34620517
155CDK90.34321724
156CCNB10.34041505
157BLK0.32843290
158ACVR1B0.32689258
159SGK20.31535218
160JAK10.31319908
161MAP2K20.31232180
162ERBB20.31133080
163MAPK30.31063503
164SYK0.31043005
165NME10.30875949
166MAP2K60.30714734
167TNIK0.29854354
168MAP3K130.29712199
169CSNK1A1L0.29097531
170NTRK20.28981835

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.95922581
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.74446955
3Fatty acid biosynthesis_Homo sapiens_hsa000613.01731093
4Circadian rhythm_Homo sapiens_hsa047102.95377851
5Nitrogen metabolism_Homo sapiens_hsa009102.76879223
6Phototransduction_Homo sapiens_hsa047442.60381843
7Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.35024839
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.24927391
9Butanoate metabolism_Homo sapiens_hsa006502.16929795
10Base excision repair_Homo sapiens_hsa034102.16238815
11Folate biosynthesis_Homo sapiens_hsa007902.12860121
12Other glycan degradation_Homo sapiens_hsa005112.09354326
13Ether lipid metabolism_Homo sapiens_hsa005652.01832101
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99508190
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.94772202
16Adherens junction_Homo sapiens_hsa045201.92213826
17Thyroid cancer_Homo sapiens_hsa052161.90817293
18N-Glycan biosynthesis_Homo sapiens_hsa005101.87032037
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.85452643
20Tryptophan metabolism_Homo sapiens_hsa003801.82644552
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.80748685
22Nicotine addiction_Homo sapiens_hsa050331.73634739
23Renin-angiotensin system_Homo sapiens_hsa046141.67066861
24Notch signaling pathway_Homo sapiens_hsa043301.62173251
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.60452755
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.54650569
27Oxidative phosphorylation_Homo sapiens_hsa001901.54190631
28Histidine metabolism_Homo sapiens_hsa003401.52032453
29Pancreatic secretion_Homo sapiens_hsa049721.45363948
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.44701625
31Pancreatic cancer_Homo sapiens_hsa052121.37205347
32ABC transporters_Homo sapiens_hsa020101.36499648
33Fructose and mannose metabolism_Homo sapiens_hsa000511.36358044
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36324305
35Galactose metabolism_Homo sapiens_hsa000521.35621421
36Selenocompound metabolism_Homo sapiens_hsa004501.33801622
37Chemical carcinogenesis_Homo sapiens_hsa052041.29526118
38Peroxisome_Homo sapiens_hsa041461.29384325
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28924624
40Morphine addiction_Homo sapiens_hsa050321.28263670
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.25981890
42Prolactin signaling pathway_Homo sapiens_hsa049171.23310173
43Taste transduction_Homo sapiens_hsa047421.22951480
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21070085
45Olfactory transduction_Homo sapiens_hsa047401.20995788
46Propanoate metabolism_Homo sapiens_hsa006401.20880904
47Mismatch repair_Homo sapiens_hsa034301.20469821
48TGF-beta signaling pathway_Homo sapiens_hsa043501.20089986
49Acute myeloid leukemia_Homo sapiens_hsa052211.19655550
50Insulin secretion_Homo sapiens_hsa049111.19136792
51Hippo signaling pathway_Homo sapiens_hsa043901.17771543
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.16466614
53Collecting duct acid secretion_Homo sapiens_hsa049661.15204714
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14876141
55mTOR signaling pathway_Homo sapiens_hsa041501.14256648
56Bladder cancer_Homo sapiens_hsa052191.12638377
57Shigellosis_Homo sapiens_hsa051311.12277572
58Serotonergic synapse_Homo sapiens_hsa047261.11303876
59Retinol metabolism_Homo sapiens_hsa008301.08684063
60Regulation of autophagy_Homo sapiens_hsa041401.07524770
61Sulfur metabolism_Homo sapiens_hsa009201.06305510
62Dorso-ventral axis formation_Homo sapiens_hsa043201.05568262
63Primary bile acid biosynthesis_Homo sapiens_hsa001201.04942879
64DNA replication_Homo sapiens_hsa030301.04287539
65beta-Alanine metabolism_Homo sapiens_hsa004101.03411038
66VEGF signaling pathway_Homo sapiens_hsa043701.01640023
67Fat digestion and absorption_Homo sapiens_hsa049751.01119518
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00353650
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99833827
70Vitamin digestion and absorption_Homo sapiens_hsa049770.99518873
71Small cell lung cancer_Homo sapiens_hsa052220.97262143
72Vibrio cholerae infection_Homo sapiens_hsa051100.96898744
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.96763163
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96059220
75Protein export_Homo sapiens_hsa030600.94707417
76Endometrial cancer_Homo sapiens_hsa052130.94480456
77Circadian entrainment_Homo sapiens_hsa047130.94162153
78Glycerolipid metabolism_Homo sapiens_hsa005610.93615183
79Platelet activation_Homo sapiens_hsa046110.91443723
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89639552
81Parkinsons disease_Homo sapiens_hsa050120.88373902
82Legionellosis_Homo sapiens_hsa051340.87699540
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86304974
84GABAergic synapse_Homo sapiens_hsa047270.85965676
85Tight junction_Homo sapiens_hsa045300.84826635
86Glutamatergic synapse_Homo sapiens_hsa047240.83087365
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.80364908
88p53 signaling pathway_Homo sapiens_hsa041150.78548146
89Herpes simplex infection_Homo sapiens_hsa051680.78150837
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.78068159
91Salivary secretion_Homo sapiens_hsa049700.78018056
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.77175811
93Protein digestion and absorption_Homo sapiens_hsa049740.76678456
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73441204
95RNA degradation_Homo sapiens_hsa030180.72812224
96Hepatitis C_Homo sapiens_hsa051600.72766689
97Type I diabetes mellitus_Homo sapiens_hsa049400.72741700
98Ovarian steroidogenesis_Homo sapiens_hsa049130.72238784
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.71989049
100Chronic myeloid leukemia_Homo sapiens_hsa052200.71725247
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70872950
102Cell cycle_Homo sapiens_hsa041100.69414465
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68997176
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68123379
105Mineral absorption_Homo sapiens_hsa049780.67945363
106Fatty acid degradation_Homo sapiens_hsa000710.66792382
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66479459
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.66136728
109Hepatitis B_Homo sapiens_hsa051610.65830035
110Colorectal cancer_Homo sapiens_hsa052100.64367391
111Dopaminergic synapse_Homo sapiens_hsa047280.64021375
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63898976
113Calcium signaling pathway_Homo sapiens_hsa040200.63254139
114Sulfur relay system_Homo sapiens_hsa041220.63107329
115Lysosome_Homo sapiens_hsa041420.62590854
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62343398
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61600945
118Cardiac muscle contraction_Homo sapiens_hsa042600.61247327
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60524611
120Huntingtons disease_Homo sapiens_hsa050160.60324721
121Alzheimers disease_Homo sapiens_hsa050100.60308704
122Caffeine metabolism_Homo sapiens_hsa002320.60186731
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59200017
124Choline metabolism in cancer_Homo sapiens_hsa052310.58811422
125RNA polymerase_Homo sapiens_hsa030200.57897156
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57346362
127Primary immunodeficiency_Homo sapiens_hsa053400.56734097
128Wnt signaling pathway_Homo sapiens_hsa043100.56648129
129Homologous recombination_Homo sapiens_hsa034400.56266455
130Cocaine addiction_Homo sapiens_hsa050300.55450375
131Measles_Homo sapiens_hsa051620.55438311
1322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55151076
133HIF-1 signaling pathway_Homo sapiens_hsa040660.54641327
134Influenza A_Homo sapiens_hsa051640.54586202
135Focal adhesion_Homo sapiens_hsa045100.54423695
136Asthma_Homo sapiens_hsa053100.53480508
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52316887
138Toxoplasmosis_Homo sapiens_hsa051450.52086213
139Metabolic pathways_Homo sapiens_hsa011000.51642254
140Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51506697
141Biosynthesis of amino acids_Homo sapiens_hsa012300.50690040
142Sphingolipid metabolism_Homo sapiens_hsa006000.48752437
143ErbB signaling pathway_Homo sapiens_hsa040120.48600257
144Intestinal immune network for IgA production_Homo sapiens_hsa046720.48179321
145Long-term depression_Homo sapiens_hsa047300.48011710
146Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47923760
147Arginine and proline metabolism_Homo sapiens_hsa003300.47158067
148Hematopoietic cell lineage_Homo sapiens_hsa046400.47107431
149Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46653435
150Gastric acid secretion_Homo sapiens_hsa049710.46313144
151Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45423127
152Amphetamine addiction_Homo sapiens_hsa050310.45289330
153Staphylococcus aureus infection_Homo sapiens_hsa051500.44127265
154Pathways in cancer_Homo sapiens_hsa052000.43023698
155Proteoglycans in cancer_Homo sapiens_hsa052050.42730909
156Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41967305
157cAMP signaling pathway_Homo sapiens_hsa040240.41599979
158Graft-versus-host disease_Homo sapiens_hsa053320.41585887
159Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41437827
160GnRH signaling pathway_Homo sapiens_hsa049120.40911973
161Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39639011
162Bile secretion_Homo sapiens_hsa049760.38570178
163Linoleic acid metabolism_Homo sapiens_hsa005910.38093454
164TNF signaling pathway_Homo sapiens_hsa046680.37962598
165Cholinergic synapse_Homo sapiens_hsa047250.37644374
166Autoimmune thyroid disease_Homo sapiens_hsa053200.37118846
167Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36921171
168Rap1 signaling pathway_Homo sapiens_hsa040150.36686527
169Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35923405
170Fatty acid metabolism_Homo sapiens_hsa012120.35881396
171Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35288906
172Basal transcription factors_Homo sapiens_hsa030220.35230464
173Allograft rejection_Homo sapiens_hsa053300.34914496
174Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33455799
175Arachidonic acid metabolism_Homo sapiens_hsa005900.31509518
176Non-small cell lung cancer_Homo sapiens_hsa052230.30945960
177Insulin signaling pathway_Homo sapiens_hsa049100.30917590
178MicroRNAs in cancer_Homo sapiens_hsa052060.29768887

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