MAOA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* phenol-containing compound catabolic process (GO:0019336)9.08264255
2behavioral response to nicotine (GO:0035095)7.89650072
3sympathetic nervous system development (GO:0048485)6.59431219
4NADH metabolic process (GO:0006734)6.01845205
5behavioral response to ethanol (GO:0048149)5.80986420
6epoxygenase P450 pathway (GO:0019373)5.58753265
7regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.38265408
8catechol-containing compound biosynthetic process (GO:0009713)5.24184231
9catecholamine biosynthetic process (GO:0042423)5.24184231
10alkaloid metabolic process (GO:0009820)5.08484156
11synaptic transmission, cholinergic (GO:0007271)4.82656187
12maternal behavior (GO:0042711)4.74983676
13dopamine biosynthetic process (GO:0042416)4.72435140
14response to water (GO:0009415)4.72138936
15norepinephrine metabolic process (GO:0042415)4.54668523
16lipoprotein transport (GO:0042953)4.53059571
17cellular glucuronidation (GO:0052695)4.45365787
18ethanol oxidation (GO:0006069)4.41088744
19urea metabolic process (GO:0019627)4.33443508
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.32315907
21urea cycle (GO:0000050)4.31617750
22uronic acid metabolic process (GO:0006063)4.27600854
23glucuronate metabolic process (GO:0019585)4.27600854
24fat-soluble vitamin biosynthetic process (GO:0042362)4.21718725
25parental behavior (GO:0060746)4.20767095
26catecholamine transport (GO:0051937)4.20134245
27diacylglycerol metabolic process (GO:0046339)4.20083009
28hormone catabolic process (GO:0042447)4.12139797
29* dopamine metabolic process (GO:0042417)4.08792968
30drug metabolic process (GO:0017144)4.00956075
31nitrogen cycle metabolic process (GO:0071941)3.97544624
32regulation of bile acid biosynthetic process (GO:0070857)3.96412426
33fructose metabolic process (GO:0006000)3.93675150
34positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.90736518
35alpha-linolenic acid metabolic process (GO:0036109)3.82167346
36negative regulation of microtubule polymerization (GO:0031115)3.78991605
37regulation of triglyceride catabolic process (GO:0010896)3.71854543
38transcytosis (GO:0045056)3.66032737
39intestinal absorption (GO:0050892)3.62573809
40enteric nervous system development (GO:0048484)3.60906477
41very-low-density lipoprotein particle assembly (GO:0034379)3.59760770
42bile acid and bile salt transport (GO:0015721)3.58312971
43response to pain (GO:0048265)3.58017489
44ethanol metabolic process (GO:0006067)3.55526009
45exogenous drug catabolic process (GO:0042738)3.51015997
46drug catabolic process (GO:0042737)3.48790127
47flavonoid metabolic process (GO:0009812)3.47831189
48regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.46675726
49endocrine process (GO:0050886)3.46675726
50regulation of systemic arterial blood pressure by hormone (GO:0001990)3.46675726
51neuromuscular synaptic transmission (GO:0007274)3.45189667
52cell migration in hindbrain (GO:0021535)3.43287963
53regulation of cholesterol homeostasis (GO:2000188)3.39656747
54triglyceride catabolic process (GO:0019433)3.38900250
55parturition (GO:0007567)3.34968208
56dopaminergic neuron differentiation (GO:0071542)3.32942442
57low-density lipoprotein particle clearance (GO:0034383)3.31569244
58proline transport (GO:0015824)3.29384615
59positive regulation of lipoprotein lipase activity (GO:0051006)3.27598087
60positive regulation of triglyceride lipase activity (GO:0061365)3.27598087
61actin filament depolymerization (GO:0030042)3.26459470
62bile acid metabolic process (GO:0008206)3.26306704
63oxaloacetate metabolic process (GO:0006107)3.24196657
64triglyceride biosynthetic process (GO:0019432)3.23990796
65phenol-containing compound biosynthetic process (GO:0046189)3.22720620
66renal system process involved in regulation of blood volume (GO:0001977)3.20977215
67mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.17226305
68neutral lipid biosynthetic process (GO:0046460)3.16593438
69acylglycerol biosynthetic process (GO:0046463)3.16593438
70positive regulation of lipid catabolic process (GO:0050996)3.15736812
71cellular response to nerve growth factor stimulus (GO:1990090)3.14567295
72response to nerve growth factor (GO:1990089)3.14567295
73carnitine shuttle (GO:0006853)3.12083692
74neutral lipid catabolic process (GO:0046461)3.10703015
75acylglycerol catabolic process (GO:0046464)3.10703015
76regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.08708334
77primary alcohol metabolic process (GO:0034308)3.08566400
78ATP synthesis coupled proton transport (GO:0015986)3.08547615
79energy coupled proton transport, down electrochemical gradient (GO:0015985)3.08547615
80ganglion development (GO:0061548)3.07632154
81adhesion of symbiont to host (GO:0044406)3.05629482
82regulation of cholesterol esterification (GO:0010872)3.05036001
83peptide hormone processing (GO:0016486)3.04968054
84fatty acid catabolic process (GO:0009062)3.02323800
85regulation of respiratory gaseous exchange (GO:0043576)3.00890374
86phospholipid efflux (GO:0033700)2.98544525
87regulation of systemic arterial blood pressure (GO:0003073)2.97483520
88fatty acid beta-oxidation (GO:0006635)2.96271536
89angiotensin maturation (GO:0002003)2.95411226
90activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.95222836
91omega-hydroxylase P450 pathway (GO:0097267)2.94079161
92fatty acid transmembrane transport (GO:1902001)2.93438428
93lipoprotein metabolic process (GO:0042157)2.93256130
94cGMP-mediated signaling (GO:0019934)2.93067526
95phospholipid homeostasis (GO:0055091)2.92114146
96plasma lipoprotein particle assembly (GO:0034377)2.90749550
97receptor guanylyl cyclase signaling pathway (GO:0007168)2.89788039
98mating behavior (GO:0007617)2.89737269
99regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.89189248
100regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.89189248
101vocalization behavior (GO:0071625)2.88898662
102glycerol metabolic process (GO:0006071)2.88692621
103triglyceride metabolic process (GO:0006641)2.87227605
104triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.86852611
105regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.85767118
106positive regulation of protein depolymerization (GO:1901881)2.84454501
107very long-chain fatty acid metabolic process (GO:0000038)2.83016272
108axon ensheathment in central nervous system (GO:0032291)2.82843033
109central nervous system myelination (GO:0022010)2.82843033
110amino-acid betaine transport (GO:0015838)2.82594575
111carnitine transport (GO:0015879)2.82594575
112regulation of cardioblast proliferation (GO:0003264)2.81468671
113regulation of secondary heart field cardioblast proliferation (GO:0003266)2.81468671
1143-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.80865586
115purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.80865586
116alditol metabolic process (GO:0019400)2.78850756
117mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.78001488
118regulation of cholesterol metabolic process (GO:0090181)2.77715897
119renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.76317591
120primary alcohol catabolic process (GO:0034310)2.74934336
121* catechol-containing compound metabolic process (GO:0009712)2.74451142
122* catecholamine metabolic process (GO:0006584)2.74451142
123peptide catabolic process (GO:0043171)2.72848495
124protein-lipid complex assembly (GO:0065005)2.72506626
125response to amphetamine (GO:0001975)2.72043171
126multi-organism reproductive behavior (GO:0044705)2.71775851
127* neurotransmitter catabolic process (GO:0042135)2.71756901
128drug transmembrane transport (GO:0006855)2.70980351
129neuron remodeling (GO:0016322)2.70429982
130biotin metabolic process (GO:0006768)2.70027489
131cholesterol homeostasis (GO:0042632)2.69886910
132bundle of His cell to Purkinje myocyte communication (GO:0086069)2.69628094
133complement activation, alternative pathway (GO:0006957)2.69327974
134glutamine family amino acid biosynthetic process (GO:0009084)2.69228773
135positive regulation of guanylate cyclase activity (GO:0031284)2.68236260
136acylglycerol metabolic process (GO:0006639)2.68171072
137plasma lipoprotein particle remodeling (GO:0034369)2.66640635
138protein-lipid complex remodeling (GO:0034368)2.66640635
139macromolecular complex remodeling (GO:0034367)2.66640635
140regulation of cGMP biosynthetic process (GO:0030826)2.66262893
141calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.66143784
142sterol homeostasis (GO:0055092)2.64787347
143arginine metabolic process (GO:0006525)2.64529228
144membrane assembly (GO:0071709)2.63975434
145cellular response to nicotine (GO:0071316)2.63694909
146toxin metabolic process (GO:0009404)2.63437493
147neutral lipid metabolic process (GO:0006638)2.62993912
148sulfate transmembrane transport (GO:1902358)2.62919676
149regulation of vitamin metabolic process (GO:0030656)2.62233661
150fatty acid oxidation (GO:0019395)2.60961868
151carnitine transmembrane transport (GO:1902603)2.60951176
152maintenance of gastrointestinal epithelium (GO:0030277)2.60244689
153cholesterol biosynthetic process (GO:0006695)2.58933399
154reproductive behavior (GO:0019098)2.58553915
155monocarboxylic acid catabolic process (GO:0072329)2.58459171
156regulation of guanylate cyclase activity (GO:0031282)2.57858111
157positive regulation of potassium ion transmembrane transport (GO:1901381)2.56895696
158neuron cell-cell adhesion (GO:0007158)2.56418264
159regulation of vesicle fusion (GO:0031338)2.55077181
160phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.54399842
161nucleobase catabolic process (GO:0046113)2.53324455
162intestinal cholesterol absorption (GO:0030299)2.53274892
163regulation of short-term neuronal synaptic plasticity (GO:0048172)2.52045048
164multicellular organismal reproductive behavior (GO:0033057)2.50949642
165response to nicotine (GO:0035094)2.47635920
166electron transport chain (GO:0022900)2.46951998
167detection of temperature stimulus involved in sensory perception (GO:0050961)2.46654930
168detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.46654930
169protein neddylation (GO:0045116)2.45871762
170cellular response to hepatocyte growth factor stimulus (GO:0035729)2.41777301
171response to hepatocyte growth factor (GO:0035728)2.41777301
172positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.40490423
173* neurotransmitter transport (GO:0006836)2.39025384
174response to corticosterone (GO:0051412)2.38591443
175response to mineralocorticoid (GO:0051385)2.37714442
176cellular copper ion homeostasis (GO:0006878)2.37088438
177glycine transport (GO:0015816)2.36961681
178negative regulation of neurotransmitter transport (GO:0051589)2.36546338
179regulation of neurotransmitter transport (GO:0051588)2.34651970
180atrial cardiac muscle cell action potential (GO:0086014)2.32261464
181respiratory electron transport chain (GO:0022904)2.31800094
182sterol biosynthetic process (GO:0016126)2.31759938
183positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.30999527
184positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.30788851
185virion attachment to host cell (GO:0019062)2.30763342
186adhesion of symbiont to host cell (GO:0044650)2.30763342
187monoamine transport (GO:0015844)2.30243714
188adult feeding behavior (GO:0008343)2.29685051
189* neurotransmitter biosynthetic process (GO:0042136)2.27141019
190phospholipid scrambling (GO:0017121)2.26656075
191detection of temperature stimulus (GO:0016048)2.26382537
192regulation of neurotransmitter uptake (GO:0051580)2.25729974

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.59459816
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.53922967
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.29902349
4CDX2_19796622_ChIP-Seq_MESCs_Mouse3.17559238
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.09732913
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.05542099
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.98651711
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.86026554
9EZH2_22144423_ChIP-Seq_EOC_Human2.74562200
10GBX2_23144817_ChIP-Seq_PC3_Human2.67129228
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.58134803
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.54431334
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.37666275
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32010005
15CLOCK_20551151_ChIP-Seq_293T_Human2.30513621
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.30192789
17EGR1_23403033_ChIP-Seq_LIVER_Mouse2.28783348
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24213906
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.23848005
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.21904223
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17120883
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17120883
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.12091806
24TP63_17297297_ChIP-ChIP_HaCaT_Human2.09129105
25JARID2_20064375_ChIP-Seq_MESCs_Mouse2.08957274
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.08418253
27GATA4_25053715_ChIP-Seq_YYC3_Human1.97316690
28CDX2_20551321_ChIP-Seq_CACO-2_Human1.96833261
29* ESR2_21235772_ChIP-Seq_MCF-7_Human1.96267660
30NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.96182803
31TAF15_26573619_Chip-Seq_HEK293_Human1.96110197
32NR3C1_23031785_ChIP-Seq_PC12_Mouse1.95759914
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94797992
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.92992520
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.84638593
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.83606712
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.83128230
38AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.83109847
39SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81245242
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.76734767
41AR_21572438_ChIP-Seq_LNCaP_Human1.75011879
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72074415
43* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.72065417
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64070466
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63363489
46GATA6_25053715_ChIP-Seq_YYC3_Human1.62956626
47GATA1_22025678_ChIP-Seq_K562_Human1.60507433
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.59071753
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56724316
50BCAT_22108803_ChIP-Seq_LS180_Human1.55137181
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54735597
52STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54598966
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.54391648
54FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.52950916
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52885772
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51736350
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50375103
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49499642
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48026480
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47131789
61VDR_22108803_ChIP-Seq_LS180_Human1.46162609
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.44037249
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43785908
64FOXA2_19822575_ChIP-Seq_HepG2_Human1.42746662
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.42582404
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.40889118
67* SOX2_20726797_ChIP-Seq_SW620_Human1.40833892
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.40139218
69* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38550650
70ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37132075
71RNF2_27304074_Chip-Seq_ESCs_Mouse1.36925580
72PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36324747
73* P300_19829295_ChIP-Seq_ESCs_Human1.35688733
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33785875
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33591908
76* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33292325
77DROSHA_22980978_ChIP-Seq_HELA_Human1.32938038
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32612392
79SMAD4_21799915_ChIP-Seq_A2780_Human1.32117376
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32069312
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.31717164
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31703996
83* FUS_26573619_Chip-Seq_HEK293_Human1.31345199
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31200490
85* ESR1_21235772_ChIP-Seq_MCF-7_Human1.31190312
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27556629
87* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27465103
88TP53_18474530_ChIP-ChIP_U2OS_Human1.24939435
89TCF4_18268006_ChIP-ChIP_LS174T_Human1.23516851
90FOXA1_25552417_ChIP-Seq_VCAP_Human1.23380049
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22343411
92Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.21475090
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21307955
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20295795
95TBX20_22328084_ChIP-Seq_HEART_Mouse1.19530516
96TBX20_22080862_ChIP-Seq_HEART_Mouse1.19530516
97* WT1_19549856_ChIP-ChIP_CCG9911_Human1.19377099
98* HNF4A_19822575_ChIP-Seq_HepG2_Human1.18891196
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17087044
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16696559
101ZNF263_19887448_ChIP-Seq_K562_Human1.16664807
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16200336
103AR_25329375_ChIP-Seq_VCAP_Human1.16142086
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15215644
105STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13711759
106TP53_16413492_ChIP-PET_HCT116_Human1.13398524
107CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13314281
108* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13109078
109* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13109078
110REST_21632747_ChIP-Seq_MESCs_Mouse1.12118612
111CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11982087
112PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.11291025
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10238482
114P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10117474
115TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.09436057
116FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08568224
117BP1_19119308_ChIP-ChIP_Hs578T_Human1.07844196
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07819934
119SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06544676
120SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04546091
121PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04381626
122CJUN_26792858_Chip-Seq_BT549_Human1.03099099
123RACK7_27058665_Chip-Seq_MCF-7_Human1.02996711
124SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02024021
125KLF5_25053715_ChIP-Seq_YYC3_Human1.01774463
126RNF2_27304074_Chip-Seq_NSC_Mouse1.01633713
127ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00674305
128LXR_22292898_ChIP-Seq_THP-1_Human0.98145819
129* RUNX2_22187159_ChIP-Seq_PCA_Human0.97593567
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97572241
131CDX2_22108803_ChIP-Seq_LS180_Human0.97305040
132PRDM14_20953172_ChIP-Seq_ESCs_Human0.97285619
133PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96630132
134TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95917936
135SOX2_21211035_ChIP-Seq_LN229_Gbm0.95540964
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95365911
137GATA3_24758297_ChIP-Seq_MCF-7_Human0.94466514
138SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94276180
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93897619
140ER_23166858_ChIP-Seq_MCF-7_Human0.93586577
141RING1B_27294783_Chip-Seq_ESCs_Mouse0.92839074
142SMAD3_21741376_ChIP-Seq_HESCs_Human0.92654121
143IRF8_22096565_ChIP-ChIP_GC-B_Human0.92532499
144SMAD4_21741376_ChIP-Seq_HESCs_Human0.92184328
145SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91944721
146TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91279058
147RXR_22108803_ChIP-Seq_LS180_Human0.90860015
148NANOG_18555785_Chip-Seq_ESCs_Mouse0.90843695
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.90166518
150EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89845101
151FOXO3_23340844_ChIP-Seq_DLD1_Human0.89765211
152MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89521685
153* AR_21909140_ChIP-Seq_LNCAP_Human0.89507368
154AHR_22903824_ChIP-Seq_MCF-7_Human0.89367570
155* STAT3_23295773_ChIP-Seq_U87_Human0.88627707
156TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88345373
157WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88261406
158BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.84991183
159NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84376778
160PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83548635
161SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83219528
162SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.81832444
163GATA2_19941826_ChIP-Seq_K562_Human0.81625961
164FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80699013
165HIF1A_21447827_ChIP-Seq_MCF-7_Human0.79061731
166NFIB_24661679_ChIP-Seq_LUNG_Mouse0.77461295
167RUNX1_27514584_Chip-Seq_MCF-7_Human0.77355675
168* TP63_23658742_ChIP-Seq_EP156T_Human0.76660934
169NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.75346688
170GATA1_19941826_ChIP-Seq_K562_Human0.74979435
171RAD21_21589869_ChIP-Seq_MESCs_Mouse0.74107159
172CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.71597901
173SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.71311422

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.05588727
2MP0010386_abnormal_urinary_bladder4.36725185
3MP0005365_abnormal_bile_salt4.03994062
4MP0005670_abnormal_white_adipose3.78239215
5MP0002638_abnormal_pupillary_reflex3.28925001
6MP0009379_abnormal_foot_pigmentation3.17445867
7MP0004270_analgesia3.04766466
8MP0000538_abnormal_urinary_bladder2.91470845
9MP0009840_abnormal_foam_cell2.87293983
10MP0004019_abnormal_vitamin_homeostasis2.82893249
11MP0010329_abnormal_lipoprotein_level2.68469430
12MP0005666_abnormal_adipose_tissue2.50726769
13MP0003183_abnormal_peptide_metabolism2.41656722
14MP0006276_abnormal_autonomic_nervous2.40444787
15MP0001529_abnormal_vocalization2.37085219
16MP0002734_abnormal_mechanical_nocicepti2.36245648
17MP0001188_hyperpigmentation2.26216939
18MP0002971_abnormal_brown_adipose2.24861330
19MP0000462_abnormal_digestive_system2.14934748
20MP0002876_abnormal_thyroid_physiology2.12245554
21* MP0001905_abnormal_dopamine_level2.04762636
22MP0005332_abnormal_amino_acid2.00402889
23MP0002822_catalepsy10.2968137
24MP0000372_irregular_coat_pigmentation1.91431494
25MP0005377_hearing/vestibular/ear_phenot1.86591229
26MP0003878_abnormal_ear_physiology1.86591229
27MP0002751_abnormal_autonomic_nervous1.83844333
28MP0009745_abnormal_behavioral_response1.83357407
29MP0002118_abnormal_lipid_homeostasis1.82660240
30* MP0001440_abnormal_grooming_behavior1.80866261
31MP0003283_abnormal_digestive_organ1.77186165
32MP0009643_abnormal_urine_homeostasis1.75428156
33MP0001970_abnormal_pain_threshold1.74168255
34MP0008872_abnormal_physiological_respon1.73721818
35MP0002733_abnormal_thermal_nociception1.72760174
36MP0004782_abnormal_surfactant_physiolog1.66092716
37MP0003191_abnormal_cellular_cholesterol1.62636016
38MP0005375_adipose_tissue_phenotype1.61708280
39MP0005171_absent_coat_pigmentation1.58916950
40MP0003252_abnormal_bile_duct1.58862046
41MP0009384_cardiac_valve_regurgitation1.54436715
42MP0001664_abnormal_digestion1.54384119
43MP0005167_abnormal_blood-brain_barrier1.51394658
44MP0010155_abnormal_intestine_physiology1.50201707
45MP0005409_darkened_coat_color1.47482727
46MP0009115_abnormal_fat_cell1.46036832
47MP0004858_abnormal_nervous_system1.45428542
48MP0005623_abnormal_meninges_morphology1.43981044
49MP0001666_abnormal_nutrient_absorption1.43790679
50MP0010352_gastrointestinal_tract_polyps1.40365497
51MP0003635_abnormal_synaptic_transmissio1.40178868
52MP0004272_abnormal_basement_membrane1.37967369
53MP0005166_decreased_susceptibility_to1.36180160
54MP0001764_abnormal_homeostasis1.34506626
55MP0005636_abnormal_mineral_homeostasis1.32560946
56MP0005535_abnormal_body_temperature1.31636694
57MP0006138_congestive_heart_failure1.31175025
58MP0002064_seizures1.30427659
59MP0005408_hypopigmentation1.30406327
60MP0010234_abnormal_vibrissa_follicle1.29860423
61MP0003879_abnormal_hair_cell1.29427261
62MP0004130_abnormal_muscle_cell1.28525182
63MP0003011_delayed_dark_adaptation1.27805662
64MP0000609_abnormal_liver_physiology1.27786601
65MP0004185_abnormal_adipocyte_glucose1.27670226
66MP0004043_abnormal_pH_regulation1.27207267
67MP0005448_abnormal_energy_balance1.25967368
68MP0001765_abnormal_ion_homeostasis1.25192141
69MP0008875_abnormal_xenobiotic_pharmacok1.21338653
70MP0000778_abnormal_nervous_system1.20931782
71MP0002138_abnormal_hepatobiliary_system1.20630050
72MP0005584_abnormal_enzyme/coenzyme_acti1.19045869
73MP0005451_abnormal_body_composition1.18973884
74* MP0002572_abnormal_emotion/affect_behav1.18846197
75MP0003866_abnormal_defecation1.18585914
76MP0009780_abnormal_chondrocyte_physiolo1.15107653
77* MP0005386_behavior/neurological_phenoty1.13779150
78* MP0004924_abnormal_behavior1.13779150
79MP0005360_urolithiasis1.13587242
80MP0004859_abnormal_synaptic_plasticity1.10764420
81MP0005334_abnormal_fat_pad1.09994957
82MP0002102_abnormal_ear_morphology1.09853880
83MP0008438_abnormal_cutaneous_collagen1.09552943
84MP0003300_gastrointestinal_ulcer1.09113638
85MP0005381_digestive/alimentary_phenotyp1.08732913
86MP0003880_abnormal_central_pattern1.08708136
87MP0001756_abnormal_urination1.07296885
88MP0003705_abnormal_hypodermis_morpholog1.06107642
89MP0001968_abnormal_touch/_nociception1.04610064
90MP0000537_abnormal_urethra_morphology1.03372310
91MP0002735_abnormal_chemical_nociception1.00256032
92MP0002136_abnormal_kidney_physiology0.99290625
93* MP0002272_abnormal_nervous_system0.99272877
94MP0005197_abnormal_uvea_morphology0.98733014
95MP0008004_abnormal_stomach_pH0.97026052
96MP0003633_abnormal_nervous_system0.96083699
97MP0004147_increased_porphyrin_level0.95444313
98MP0001486_abnormal_startle_reflex0.95299516
99MP0005319_abnormal_enzyme/_coenzyme0.94588245
100MP0005085_abnormal_gallbladder_physiolo0.94494384
101MP0002163_abnormal_gland_morphology0.94048796
102MP0002078_abnormal_glucose_homeostasis0.93848095
103MP0005423_abnormal_somatic_nervous0.93391044
104MP0000230_abnormal_systemic_arterial0.92404525
105MP0005058_abnormal_lysosome_morphology0.90429856
106MP0000604_amyloidosis0.88669796
107MP0001663_abnormal_digestive_system0.87469294
108MP0000762_abnormal_tongue_morphology0.87333581
109MP0003724_increased_susceptibility_to0.86843944
110MP0000477_abnormal_intestine_morphology0.86148567
111MP0009697_abnormal_copulation0.85779097
112* MP0002063_abnormal_learning/memory/cond0.85592800
113MP0002184_abnormal_innervation0.85520345
114MP0003279_aneurysm0.84103816
115MP0003075_altered_response_to0.83846525
116MP0002166_altered_tumor_susceptibility0.82467250
117MP0004742_abnormal_vestibular_system0.82159447
118MP0010678_abnormal_skin_adnexa0.81743850
119MP0003631_nervous_system_phenotype0.81398557
120MP0000566_synostosis0.80593259
121MP0000249_abnormal_blood_vessel0.79316537
122MP0009046_muscle_twitch0.78861473
123MP0008569_lethality_at_weaning0.78789716
124MP0003937_abnormal_limbs/digits/tail_de0.78182294
125MP0005503_abnormal_tendon_morphology0.77884720
126MP0000049_abnormal_middle_ear0.76839761
127MP0000003_abnormal_adipose_tissue0.76626294
128MP0005275_abnormal_skin_tensile0.76335417
129MP0002970_abnormal_white_adipose0.76022508
130MP0003959_abnormal_lean_body0.75697241
131MP0001881_abnormal_mammary_gland0.75677185
132MP0002090_abnormal_vision0.75188356
133MP0003806_abnormal_nucleotide_metabolis0.75094717
134MP0000678_abnormal_parathyroid_gland0.74880271
135MP0009250_abnormal_appendicular_skeleto0.73056949
136MP0010368_abnormal_lymphatic_system0.72723366
137MP0005165_increased_susceptibility_to0.72167948
138MP0003453_abnormal_keratinocyte_physiol0.71409086
139MP0002009_preneoplasia0.71233506
140* MP0003953_abnormal_hormone_level0.70706389
141MP0002127_abnormal_cardiovascular_syste0.69502913
142MP0004215_abnormal_myocardial_fiber0.69015635
143MP0002896_abnormal_bone_mineralization0.68713972
144MP0003868_abnormal_feces_composition0.68596412
145MP0000013_abnormal_adipose_tissue0.68235770
146MP0002909_abnormal_adrenal_gland0.67637908
147* MP0009642_abnormal_blood_homeostasis0.67466426
148MP0003195_calcinosis0.67388836
149MP0005367_renal/urinary_system_phenotyp0.66828195
150MP0000516_abnormal_urinary_system0.66828195
151MP0002736_abnormal_nociception_after0.66603940
152MP0001177_atelectasis0.65808703
153* MP0002557_abnormal_social/conspecific_i0.65427105
154MP0004264_abnormal_extraembryonic_tissu0.64706625
155MP0006072_abnormal_retinal_apoptosis0.64295125
156MP0002098_abnormal_vibrissa_morphology0.63069064
157MP0004947_skin_inflammation0.63057643
158* MP0002067_abnormal_sensory_capabilities0.62486296
159MP0001340_abnormal_eyelid_morphology0.62124639
160MP0003941_abnormal_skin_development0.62061630
161MP0001958_emphysema0.61443093
162MP0003690_abnormal_glial_cell0.61169423
163MP0000383_abnormal_hair_follicle0.60566085
164MP0004484_altered_response_of0.60299368
165* MP0002882_abnormal_neuron_morphology0.58985526
166MP0005379_endocrine/exocrine_gland_phen0.58890205
167MP0000467_abnormal_esophagus_morphology0.58480952
168MP0002796_impaired_skin_barrier0.57962470
169MP0005647_abnormal_sex_gland0.57401915
170* MP0002066_abnormal_motor_capabilities/c0.56941314
171MP0002160_abnormal_reproductive_system0.56790298
172MP0001963_abnormal_hearing_physiology0.56776934
173MP0003136_yellow_coat_color0.56589054
174MP0002752_abnormal_somatic_nervous0.55855886
175MP0002233_abnormal_nose_morphology0.55534903
176MP0005551_abnormal_eye_electrophysiolog0.54703889
177MP0003385_abnormal_body_wall0.53321177

Predicted human phenotypes

RankGene SetZ-score
1Orthostatic hypotension (HP:0001278)6.38225117
2Abnormal autonomic nervous system physiology (HP:0012332)5.41109134
3Hydroxyprolinuria (HP:0003080)4.86454014
4Abnormality of proline metabolism (HP:0010907)4.86454014
5Malnutrition (HP:0004395)4.82264554
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.80781080
7Systemic lupus erythematosus (HP:0002725)4.77507261
8Myokymia (HP:0002411)4.61114423
9Neonatal hypoglycemia (HP:0001998)4.57684326
10Complement deficiency (HP:0004431)4.56538188
11Fat malabsorption (HP:0002630)4.42527640
12Ileus (HP:0002595)4.35539963
13Hypobetalipoproteinemia (HP:0003563)4.17965139
14Limb dystonia (HP:0002451)4.04407023
15Abnormality of complement system (HP:0005339)3.86322571
16Exotropia (HP:0000577)3.72193449
17Xanthomatosis (HP:0000991)3.70880290
18Glomerulonephritis (HP:0000099)3.39901237
19Autoamputation (HP:0001218)3.37985489
20Hypotension (HP:0002615)3.32738320
21Decreased circulating renin level (HP:0003351)3.28746962
22Widely patent fontanelles and sutures (HP:0004492)3.27479649
23Symphalangism affecting the phalanges of the hand (HP:0009773)3.26978543
24Sensory axonal neuropathy (HP:0003390)3.25108452
25Amblyopia (HP:0000646)3.22864535
26Steatorrhea (HP:0002570)3.16244072
27Abnormality of vitamin metabolism (HP:0100508)3.06535690
28Pigmentary retinal degeneration (HP:0001146)3.05548349
29Hemorrhage of the eye (HP:0011885)3.02632542
30Hyperammonemia (HP:0001987)3.02600506
31Intrahepatic cholestasis (HP:0001406)3.00201306
32Hyperglycinuria (HP:0003108)2.98235703
33Nausea (HP:0002018)2.97062753
34Chronic diarrhea (HP:0002028)2.94944212
35Epidermoid cyst (HP:0200040)2.93123545
36Metabolic alkalosis (HP:0200114)2.81980064
37Proximal tubulopathy (HP:0000114)2.80544160
38Abnormality of the vitamin B12 metabolism (HP:0004341)2.79179103
39Thin bony cortex (HP:0002753)2.76291287
40Termporal pattern (HP:0011008)2.72980358
41Insidious onset (HP:0003587)2.72980358
42Abnormality of renin-angiotensin system (HP:0000847)2.72868434
43Abnormality of vitamin B metabolism (HP:0004340)2.72244567
44Hypolipoproteinemia (HP:0010981)2.66385635
45Acanthocytosis (HP:0001927)2.65734310
46Abnormality of serine family amino acid metabolism (HP:0010894)2.62764379
47Abnormality of glycine metabolism (HP:0010895)2.62764379
48Nephritis (HP:0000123)2.58221302
49Hypoventilation (HP:0002791)2.58155446
50Alkalosis (HP:0001948)2.57199420
51Cupped ribs (HP:0000887)2.51429131
52Glycosuria (HP:0003076)2.49939065
53Abnormality of urine glucose concentration (HP:0011016)2.49939065
54Fragile skin (HP:0001030)2.49911949
55Abnormality of the corticospinal tract (HP:0002492)2.49858950
56Skin nodule (HP:0200036)2.49237578
57Acute necrotizing encephalopathy (HP:0006965)2.48878660
58Atonic seizures (HP:0010819)2.48140901
59Action tremor (HP:0002345)2.47781188
60Confusion (HP:0001289)2.46715076
61Wide cranial sutures (HP:0010537)2.44825335
62Short hallux (HP:0010109)2.41060234
63Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.40540928
64Abnormal pupillary function (HP:0007686)2.37023161
65Hyperlipoproteinemia (HP:0010980)2.34793575
66Focal segmental glomerulosclerosis (HP:0000097)2.34748303
67Ulnar claw (HP:0001178)2.33691276
68Abnormality of the 2nd finger (HP:0004100)2.33559534
69Recurrent corneal erosions (HP:0000495)2.33378466
70Hyperthyroidism (HP:0000836)2.32189942
71Abnormality of aromatic amino acid family metabolism (HP:0004338)2.32049148
72Deep venous thrombosis (HP:0002625)2.30382925
73Conjugated hyperbilirubinemia (HP:0002908)2.27568188
74Focal motor seizures (HP:0011153)2.27063740
75Abnormality of the 1st metacarpal (HP:0010009)2.26328399
76Bradycardia (HP:0001662)2.25577851
77Focal seizures (HP:0007359)2.25494559
78Progressive macrocephaly (HP:0004481)2.25395438
79Aplasia of the phalanges of the hand (HP:0009802)2.23833735
80Aplasia involving bones of the extremities (HP:0009825)2.23833735
81Aplasia involving bones of the upper limbs (HP:0009823)2.23833735
82Abnormality of purine metabolism (HP:0004352)2.22118764
83Abnormality of fatty-acid metabolism (HP:0004359)2.21647653
84Overfolded helix (HP:0000396)2.21025617
85Growth hormone excess (HP:0000845)2.20135484
86Nephrolithiasis (HP:0000787)2.19157081
87Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.18848041
88Degeneration of the lateral corticospinal tracts (HP:0002314)2.18848041
89Hypophosphatemia (HP:0002148)2.17358304
90Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.16311499
91Microglossia (HP:0000171)2.15795121
92Hyperuricemia (HP:0002149)2.15262356
93Increased purine levels (HP:0004368)2.15262356
94Abnormal glucose tolerance (HP:0001952)2.14374386
95Right ventricular cardiomyopathy (HP:0011663)2.13223432
96Axonal loss (HP:0003447)2.12476246
97Progressive cerebellar ataxia (HP:0002073)2.12402599
98Abnormally folded helix (HP:0008544)2.11751194
99Aplasia/Hypoplasia of the hallux (HP:0008362)2.09589486
100Rickets (HP:0002748)2.08285418
101Renal tubular acidosis (HP:0001947)2.07582059
102Vascular calcification (HP:0004934)2.07429786
103Metabolic acidosis (HP:0001942)2.06932860
104Short tibia (HP:0005736)2.05464948
105Abnormality of the middle phalanges of the toes (HP:0010183)2.05164815
106Acanthosis nigricans (HP:0000956)2.04141660
107Aplasia cutis congenita (HP:0001057)2.03036540
108Abnormality of the distal phalanx of the thumb (HP:0009617)2.02303211
109Hyperaldosteronism (HP:0000859)2.02139834
110Hypothermia (HP:0002045)11.0592094
111Congenital sensorineural hearing impairment (HP:0008527)1.99892657
112Pancreatitis (HP:0001733)1.98844388
113Hypertriglyceridemia (HP:0002155)1.97512330
114Generalized aminoaciduria (HP:0002909)1.97510090
115Abnormality of carpal bone ossification (HP:0006257)1.97352359
116Subcapsular cataract (HP:0000523)1.97161053
117Rhabdomyolysis (HP:0003201)1.96533690
118Hypercholesterolemia (HP:0003124)1.95291977
119Abnormal mitochondria in muscle tissue (HP:0008316)1.94813903
120Abnormality of nucleobase metabolism (HP:0010932)1.94030222
121Abnormality of chloride homeostasis (HP:0011422)1.93878317
122Glomerulosclerosis (HP:0000096)1.92563553
123Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.91923408
124Enlarged epiphyses (HP:0010580)1.91736196
125Pheochromocytoma (HP:0002666)1.91082676
126Neonatal short-limb short stature (HP:0008921)1.91039992
127Hypoglycemic coma (HP:0001325)1.90994163
128Cerebral inclusion bodies (HP:0100314)1.90896504
129Cardiovascular calcification (HP:0011915)1.90881109
130Myotonia (HP:0002486)1.90566645
131Atrophic scars (HP:0001075)1.90549668
132Broad metatarsal (HP:0001783)1.89409108
133External ophthalmoplegia (HP:0000544)1.88263861
134Bone cyst (HP:0012062)1.87967422
135Xerostomia (HP:0000217)1.86962661
136Aplasia/Hypoplasia of the tibia (HP:0005772)1.86619832
137Hyperparathyroidism (HP:0000843)1.85786959
138Flat acetabular roof (HP:0003180)1.85676133
139Postural tremor (HP:0002174)1.84563277
140Spinal cord compression (HP:0002176)1.83634051
141Acute encephalopathy (HP:0006846)1.82640586
142Stenosis of the external auditory canal (HP:0000402)1.82623011
143Tetraparesis (HP:0002273)1.82368419
144Dicarboxylic aciduria (HP:0003215)1.81983821
145Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81983821
146Facial shape deformation (HP:0011334)1.81531369
147Potter facies (HP:0002009)1.81531369
148Protuberant abdomen (HP:0001538)1.80413360
149Myocardial infarction (HP:0001658)1.79661570
150Delayed epiphyseal ossification (HP:0002663)1.79651056
151Neurofibrillary tangles (HP:0002185)1.78266468
152Distal lower limb amyotrophy (HP:0008944)1.77194168
153Visceral angiomatosis (HP:0100761)1.76392429
154Glossoptosis (HP:0000162)1.76004638
155Myoglobinuria (HP:0002913)1.74790239
156Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74659805
157Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.74432404
158Anhidrosis (HP:0000970)1.71551405
159Mitochondrial inheritance (HP:0001427)1.71448859
160Oligomenorrhea (HP:0000876)1.70689323
161Cerebral palsy (HP:0100021)1.69895539
162Optic disc pallor (HP:0000543)1.67465861
163Irritability (HP:0000737)1.67120061
164Syncope (HP:0001279)1.66889860
165Abnormality of the costochondral junction (HP:0000919)1.66615190
166Parakeratosis (HP:0001036)1.66050107
167Abnormality of the proximal phalanges of the hand (HP:0009834)1.65515831
168Septate vagina (HP:0001153)1.64885349
169Gastrointestinal dysmotility (HP:0002579)1.64415485
170Increased hepatocellular lipid droplets (HP:0006565)1.64339750
171Relative macrocephaly (HP:0004482)1.63057875
172Onycholysis (HP:0001806)1.61210994
173Abnormality of glutamine family amino acid metabolism (HP:0010902)1.60486681
174Generalized tonic-clonic seizures (HP:0002069)1.60039475
175Agitation (HP:0000713)1.59496925
176Metaphyseal dysplasia (HP:0100255)1.59455239
177Diminished movement (HP:0002374)1.58164438
178Neuroendocrine neoplasm (HP:0100634)1.56956301
179Upper limb muscle weakness (HP:0003484)1.55257798
180Prolonged QT interval (HP:0001657)1.54778186
181Hyperactive renin-angiotensin system (HP:0000841)1.54019271
182Hemiparesis (HP:0001269)1.53317407
183Abdominal distention (HP:0003270)1.53150260
184Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.52726124
185Short phalanx of the thumb (HP:0009660)1.51919684
186Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.51823110

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK14.40986780
2ACVR1B4.32931115
3GRK73.56661513
4ERN13.38317643
5EPHA22.88152351
6FRK2.87653161
7MST1R2.73737143
8LMTK22.57182339
9MST42.51005520
10MAPKAPK52.50441610
11MATK2.47450723
12STK392.24398970
13GRK52.20917337
14PRKD32.17546130
15EPHA32.10267549
16CASK2.02374272
17TRIB32.01673526
18LIMK11.94883896
19MET1.93393748
20PIK3CA1.83055022
21DDR21.82428440
22EPHB21.71632308
23MAP3K41.71625783
24MYLK1.69876930
25MAP3K121.69515108
26NME11.69355579
27MAP2K11.64978256
28PNCK1.64922567
29FGFR41.64007531
30PRKG21.61930445
31MAP2K21.54372167
32NTRK31.52003040
33EPHB11.47135893
34EEF2K1.40807956
35TESK11.39780097
36CSNK1G31.38274380
37FGR1.34917380
38MAP3K21.33962747
39PRKCE1.32221210
40STK241.29160327
41OXSR11.28486792
42ADRBK11.28166389
43GRK61.28089816
44PDK21.26371691
45CAMK2B1.26098747
46CSNK1G21.24598230
47PTK61.22319694
48CAMK2D1.21260780
49WNK11.19748549
50TGFBR21.18674908
51FGFR31.16070907
52CAMK1D1.15015662
53SIK11.14975229
54PDPK11.14296369
55NLK1.11654420
56ICK1.11617729
57CSNK1G11.11263148
58TIE11.10592043
59MAPKAPK31.10498805
60AKT31.10291908
61DMPK1.10032620
62ARAF1.08480723
63MARK11.08457024
64PAK31.07091290
65MAP3K31.06744882
66NTRK21.05341889
67INSRR1.05249962
68PBK1.04744561
69NEK91.04518095
70CDC42BPA1.04300701
71GRK11.03237068
72WNK41.01644571
73PTK2B1.01203011
74MINK10.99483858
75PRPF4B0.97927584
76FER0.95825256
77TNIK0.95448208
78BCR0.94916536
79CAMK2G0.93424738
80MAP3K10.93160689
81TYK20.91100433
82MAP2K70.90752993
83ERBB20.88104332
84RET0.87617087
85PKN20.85812623
86CAMK2A0.83704391
87ERBB40.82328938
88ABL20.82106964
89BMPR1B0.81003116
90UHMK10.79171786
91PTK20.79021021
92PLK20.78865909
93KSR20.78172831
94MAP3K90.76617400
95JAK10.76410001
96PRKACG0.75504244
97CDK150.72369574
98CDK140.72044612
99CDK60.71628681
100ROCK20.71602979
101TRPM70.70745586
102CDK180.69748899
103CDK50.69621954
104PDK10.67581897
105STK110.67051157
106SGK30.67006784
107SGK20.66546707
108PDGFRB0.64575273
109SGK2230.62684141
110SGK4940.62684141
111CDK11A0.62282594
112ROCK10.61867928
113EPHA40.61386131
114MUSK0.59598835
115LATS20.59270935
116MAP3K60.58499208
117PRKD20.58444664
118MAPK130.58002879
119MAP3K100.57727110
120PDGFRA0.55382593
121MAP2K40.55319675
122PRKAA10.55056414
123PAK20.54434542
124MAP2K60.54247653
125CAMKK20.53823055
126CSNK1A1L0.53122614
127PRKAA20.52630055
128PRKG10.52032425
129RPS6KA20.51270420
130LATS10.50246666
131PHKG20.49118815
132PHKG10.49118815
133DAPK20.48898831
134RIPK10.48839884
135SRC0.48688026
136GSK3A0.48210658
137PRKD10.47789184
138JAK20.47589411
139YES10.47521310
140CSNK1E0.45653269
141PRKCZ0.45227635
142PRKCI0.44144215
143CAMK1G0.43191535
144PKN10.42343112
145TYRO30.41348447
146IRAK30.40931561
147IRAK10.40534015
148IGF1R0.39489239
149DYRK20.39425224
150TAOK10.39394641
151DAPK30.38832816
152PRKACA0.38485337
153TBK10.38167615
154INSR0.37986129
155MAPK110.37971165
156ILK0.37596228
157FYN0.37525086
158PAK40.37477637
159MAPK40.35008509
160PRKCA0.33513924
161MAPK120.32943548
162MAPK70.30959788

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.98812195
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.39394337
3Mineral absorption_Homo sapiens_hsa049783.12638260
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.84040974
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.78125212
6Oxidative phosphorylation_Homo sapiens_hsa001902.73375122
7PPAR signaling pathway_Homo sapiens_hsa033202.69693719
8Fatty acid degradation_Homo sapiens_hsa000712.40517682
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.39687520
10Parkinsons disease_Homo sapiens_hsa050122.35509516
11Arginine biosynthesis_Homo sapiens_hsa002202.35281526
12Retinol metabolism_Homo sapiens_hsa008302.21078611
13Caffeine metabolism_Homo sapiens_hsa002322.14258494
14Alzheimers disease_Homo sapiens_hsa050102.06321849
15Fat digestion and absorption_Homo sapiens_hsa049752.00907758
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.98901592
17* Tyrosine metabolism_Homo sapiens_hsa003501.96379912
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.94119230
19Bile secretion_Homo sapiens_hsa049761.77844517
20Cholinergic synapse_Homo sapiens_hsa047251.74715934
21Fatty acid biosynthesis_Homo sapiens_hsa000611.74066229
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.70414920
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.66903962
24* Serotonergic synapse_Homo sapiens_hsa047261.62029984
25Fatty acid metabolism_Homo sapiens_hsa012121.61821258
26Salivary secretion_Homo sapiens_hsa049701.61687840
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56490449
28Renin-angiotensin system_Homo sapiens_hsa046141.53835362
29* Histidine metabolism_Homo sapiens_hsa003401.49458121
30Renin secretion_Homo sapiens_hsa049241.47563701
31* Cocaine addiction_Homo sapiens_hsa050301.47545455
32* Tryptophan metabolism_Homo sapiens_hsa003801.46515421
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.46104729
34Long-term depression_Homo sapiens_hsa047301.45640491
35Pancreatic secretion_Homo sapiens_hsa049721.44437350
36Huntingtons disease_Homo sapiens_hsa050161.43520089
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.35232878
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.31841353
39Gap junction_Homo sapiens_hsa045401.31746227
40Complement and coagulation cascades_Homo sapiens_hsa046101.30000299
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27380146
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.26884508
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26852705
44Propanoate metabolism_Homo sapiens_hsa006401.24655711
45Gastric acid secretion_Homo sapiens_hsa049711.24479361
46* Dopaminergic synapse_Homo sapiens_hsa047281.23889184
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21478175
48Steroid biosynthesis_Homo sapiens_hsa001001.21477328
49Cardiac muscle contraction_Homo sapiens_hsa042601.21448052
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20779229
51Sphingolipid metabolism_Homo sapiens_hsa006001.20496268
52Synaptic vesicle cycle_Homo sapiens_hsa047211.20474764
53Pyruvate metabolism_Homo sapiens_hsa006201.19755730
54Protein digestion and absorption_Homo sapiens_hsa049741.19261035
55Vibrio cholerae infection_Homo sapiens_hsa051101.18975554
56Axon guidance_Homo sapiens_hsa043601.18444789
57Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17643187
58* Amphetamine addiction_Homo sapiens_hsa050311.15525191
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15508818
60Ether lipid metabolism_Homo sapiens_hsa005651.15019393
61African trypanosomiasis_Homo sapiens_hsa051431.14862728
62* Arginine and proline metabolism_Homo sapiens_hsa003301.11830458
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11447246
64Arachidonic acid metabolism_Homo sapiens_hsa005901.11432292
65Nicotine addiction_Homo sapiens_hsa050331.11376302
66Glutamatergic synapse_Homo sapiens_hsa047241.09585595
67Vascular smooth muscle contraction_Homo sapiens_hsa042701.08548250
68Tight junction_Homo sapiens_hsa045301.07166599
69GnRH signaling pathway_Homo sapiens_hsa049121.06380384
70beta-Alanine metabolism_Homo sapiens_hsa004101.03775814
71Insulin secretion_Homo sapiens_hsa049111.03765170
72Collecting duct acid secretion_Homo sapiens_hsa049661.03344501
73Vitamin digestion and absorption_Homo sapiens_hsa049771.02061054
74Circadian entrainment_Homo sapiens_hsa047130.99187316
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99043678
76Taste transduction_Homo sapiens_hsa047420.98670803
77Butanoate metabolism_Homo sapiens_hsa006500.98666973
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95514065
79Linoleic acid metabolism_Homo sapiens_hsa005910.95135788
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94405277
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.93849723
82Peroxisome_Homo sapiens_hsa041460.91982545
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88799426
84Fatty acid elongation_Homo sapiens_hsa000620.88494525
85Thyroid hormone synthesis_Homo sapiens_hsa049180.83103699
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82162401
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.81586033
88Ovarian steroidogenesis_Homo sapiens_hsa049130.77378816
89Dorso-ventral axis formation_Homo sapiens_hsa043200.76898535
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76169223
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76012379
92GABAergic synapse_Homo sapiens_hsa047270.75982414
93Melanogenesis_Homo sapiens_hsa049160.75870521
94Fructose and mannose metabolism_Homo sapiens_hsa000510.71523960
95Long-term potentiation_Homo sapiens_hsa047200.70580655
96Carbon metabolism_Homo sapiens_hsa012000.69964551
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69216121
98Glycerolipid metabolism_Homo sapiens_hsa005610.68731862
99* Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68531901
100Olfactory transduction_Homo sapiens_hsa047400.68171538
101Oxytocin signaling pathway_Homo sapiens_hsa049210.65677928
102Insulin resistance_Homo sapiens_hsa049310.65038919
103Calcium signaling pathway_Homo sapiens_hsa040200.65015866
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64772758
105Estrogen signaling pathway_Homo sapiens_hsa049150.64135612
106Starch and sucrose metabolism_Homo sapiens_hsa005000.63523762
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62208262
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.61874504
109Staphylococcus aureus infection_Homo sapiens_hsa051500.60881310
110ABC transporters_Homo sapiens_hsa020100.60649448
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60269604
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.59343563
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58145209
114Galactose metabolism_Homo sapiens_hsa000520.56851678
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56383957
116AMPK signaling pathway_Homo sapiens_hsa041520.55766539
117Folate biosynthesis_Homo sapiens_hsa007900.55495842
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55102924
119Morphine addiction_Homo sapiens_hsa050320.53986202
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53342794
121ECM-receptor interaction_Homo sapiens_hsa045120.52642806
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51915216
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51618347
124Glutathione metabolism_Homo sapiens_hsa004800.50684031
125Prion diseases_Homo sapiens_hsa050200.49313260
126Other glycan degradation_Homo sapiens_hsa005110.49140487
127Vitamin B6 metabolism_Homo sapiens_hsa007500.49104601
128* Alcoholism_Homo sapiens_hsa050340.48950098
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46705961
130* Phenylalanine metabolism_Homo sapiens_hsa003600.44317807
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.43613972
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42460423
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42428859
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42387122
135Chemical carcinogenesis_Homo sapiens_hsa052040.41590861
136cAMP signaling pathway_Homo sapiens_hsa040240.41348004
137Phototransduction_Homo sapiens_hsa047440.40391503
138Steroid hormone biosynthesis_Homo sapiens_hsa001400.40296759
139Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38413531
140Sulfur relay system_Homo sapiens_hsa041220.38337772
141Biosynthesis of amino acids_Homo sapiens_hsa012300.38316682
142* Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37336728
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37264208
144Glucagon signaling pathway_Homo sapiens_hsa049220.36318214
145Pentose phosphate pathway_Homo sapiens_hsa000300.29265539
146Pertussis_Homo sapiens_hsa051330.28248325
147Insulin signaling pathway_Homo sapiens_hsa049100.27582068
148Amoebiasis_Homo sapiens_hsa051460.24148423
149* Metabolic pathways_Homo sapiens_hsa011000.22065322
150Hepatitis C_Homo sapiens_hsa051600.19869377
151Glycosaminoglycan degradation_Homo sapiens_hsa005310.16786265
152Nitrogen metabolism_Homo sapiens_hsa009100.16327441
153Leukocyte transendothelial migration_Homo sapiens_hsa046700.07704543
154Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.03039745
155Lysine degradation_Homo sapiens_hsa003100.02400138

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