MAP1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.16897143
2neuron cell-cell adhesion (GO:0007158)5.54362042
3cell migration in hindbrain (GO:0021535)5.36139833
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.05364689
5synaptic vesicle maturation (GO:0016188)4.99692317
6vocalization behavior (GO:0071625)4.97937126
7nucleobase catabolic process (GO:0046113)4.90686923
8neurofilament cytoskeleton organization (GO:0060052)4.81179398
9synaptic vesicle exocytosis (GO:0016079)4.79311314
10negative regulation of dendrite morphogenesis (GO:0050774)4.70634597
11protein localization to synapse (GO:0035418)4.65526404
12regulation of synaptic vesicle exocytosis (GO:2000300)4.64716217
13glutamate secretion (GO:0014047)4.59565693
14behavioral response to nicotine (GO:0035095)4.45168962
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.30285794
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.22883659
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.17107783
18exploration behavior (GO:0035640)4.16346458
19layer formation in cerebral cortex (GO:0021819)4.13367820
20postsynaptic membrane organization (GO:0001941)4.11475881
21negative regulation of dendrite development (GO:2000171)4.09435522
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.08349771
23neuron recognition (GO:0008038)4.07693553
24regulation of synaptic vesicle transport (GO:1902803)4.03361938
25locomotory exploration behavior (GO:0035641)4.01946791
26proline transport (GO:0015824)4.00602408
27negative regulation of microtubule polymerization (GO:0031115)3.95556296
28regulation of glutamate receptor signaling pathway (GO:1900449)3.91965770
29axonal fasciculation (GO:0007413)3.91913914
30retinal ganglion cell axon guidance (GO:0031290)3.90910323
31detection of temperature stimulus involved in sensory perception (GO:0050961)3.83557580
32detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.83557580
33regulation of NFAT protein import into nucleus (GO:0051532)3.83383673
34dendrite morphogenesis (GO:0048813)3.81685987
35neurotransmitter secretion (GO:0007269)3.71451489
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.70870885
37innervation (GO:0060384)3.68646789
38presynaptic membrane assembly (GO:0097105)3.65994717
39neurotransmitter-gated ion channel clustering (GO:0072578)3.64289989
40regulation of synapse structural plasticity (GO:0051823)3.61679378
41detection of temperature stimulus (GO:0016048)3.60966012
42synapse assembly (GO:0007416)3.56731552
43olfactory bulb development (GO:0021772)3.54190239
44gamma-aminobutyric acid transport (GO:0015812)3.53859941
45central nervous system projection neuron axonogenesis (GO:0021952)3.50702719
46regulation of neuronal synaptic plasticity (GO:0048168)3.50360750
47neuronal ion channel clustering (GO:0045161)3.43952612
48limb bud formation (GO:0060174)3.43065584
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.42921973
50spinal cord development (GO:0021510)3.41986378
51axon cargo transport (GO:0008088)3.41131017
52substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.40356316
53substrate-independent telencephalic tangential migration (GO:0021826)3.40356316
54regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.34828866
55adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.34810644
56neuronal action potential propagation (GO:0019227)3.32699492
57* axon extension (GO:0048675)3.32311828
58membrane depolarization during action potential (GO:0086010)3.32253076
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31576229
60forebrain neuron differentiation (GO:0021879)3.30523891
61positive regulation of synapse maturation (GO:0090129)3.29527753
62mechanosensory behavior (GO:0007638)3.27234547
63dendritic spine morphogenesis (GO:0060997)3.26408731
64presynaptic membrane organization (GO:0097090)3.23847129
65ionotropic glutamate receptor signaling pathway (GO:0035235)3.22954510
66positive regulation of synapse assembly (GO:0051965)3.20427146
67regulation of long-term neuronal synaptic plasticity (GO:0048169)3.19236786
68regulation of cAMP-dependent protein kinase activity (GO:2000479)3.18289934
69negative regulation of axon guidance (GO:1902668)3.18121015
70synaptic transmission, glutamatergic (GO:0035249)3.16819573
71positive regulation of synaptic transmission, GABAergic (GO:0032230)3.16590508
72* organelle transport along microtubule (GO:0072384)3.08072595
73vesicle transport along microtubule (GO:0047496)3.07508815
74glutamate receptor signaling pathway (GO:0007215)3.06487629
75dopamine receptor signaling pathway (GO:0007212)3.05367890
76synaptic vesicle endocytosis (GO:0048488)3.04334913
77neuronal action potential (GO:0019228)3.03470255
78activation of protein kinase A activity (GO:0034199)3.03040364
79adult walking behavior (GO:0007628)3.02984873
80neuron-neuron synaptic transmission (GO:0007270)3.01502769
81hippocampus development (GO:0021766)3.01159889
82regulation of neurotransmitter secretion (GO:0046928)2.99780995
83response to auditory stimulus (GO:0010996)2.98007148
84neurotransmitter transport (GO:0006836)2.94655619
85negative regulation of synaptic transmission, GABAergic (GO:0032229)2.94098822
86behavioral response to ethanol (GO:0048149)2.94049450
87calcium-mediated signaling using intracellular calcium source (GO:0035584)2.93933402
88regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.93686250
89negative regulation of axon extension (GO:0030517)2.93239831
90* neuron projection extension (GO:1990138)2.92654878
91auditory behavior (GO:0031223)2.92346810
92regulation of axon guidance (GO:1902667)2.91636731
93startle response (GO:0001964)2.90778099
94negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.89772301
95positive regulation of dendritic spine morphogenesis (GO:0061003)2.88599460
96central nervous system neuron axonogenesis (GO:0021955)2.88194646
97regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.87153793
98cerebellar Purkinje cell differentiation (GO:0021702)2.86476592
99positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.85539160
100cerebellum development (GO:0021549)2.85514236
101regulation of excitatory postsynaptic membrane potential (GO:0060079)2.84878245
102regulation of glycogen (starch) synthase activity (GO:2000465)2.84073113
103protein polyglutamylation (GO:0018095)2.83690010
104neural tube formation (GO:0001841)2.82044184
105regulation of vesicle fusion (GO:0031338)2.81878376
106regulation of synaptic transmission, glutamatergic (GO:0051966)2.81178660
107regulation of postsynaptic membrane potential (GO:0060078)2.80579892
108neuron migration (GO:0001764)2.79911976
109response to pheromone (GO:0019236)2.79656274
110neuromuscular synaptic transmission (GO:0007274)2.79440841
111neuromuscular process controlling balance (GO:0050885)2.79403092
112* establishment of mitochondrion localization (GO:0051654)2.78994718
113ganglion development (GO:0061548)2.78553987
114cerebral cortex radially oriented cell migration (GO:0021799)2.78197102
115positive regulation of membrane potential (GO:0045838)2.77681281
116synapse organization (GO:0050808)2.77460409
117inositol phosphate catabolic process (GO:0071545)2.77162993
118clathrin coat assembly (GO:0048268)2.76287735
119establishment of vesicle localization (GO:0051650)2.75711756
120positive regulation of potassium ion transmembrane transport (GO:1901381)2.75694033
121* positive regulation of axon extension (GO:0045773)2.74204167
122transmission of nerve impulse (GO:0019226)2.74197141
123cell proliferation in forebrain (GO:0021846)2.72822676
124membrane depolarization (GO:0051899)2.72422152
125* regulation of axon extension (GO:0030516)2.71635946
126short-term memory (GO:0007614)2.71008759
127regulation of collateral sprouting (GO:0048670)2.69729168
128negative regulation of transcription regulatory region DNA binding (GO:2000678)2.68162679
129nonmotile primary cilium assembly (GO:0035058)2.67856916
130intraciliary transport (GO:0042073)2.67806708
131negative regulation of axonogenesis (GO:0050771)2.66466695
132head development (GO:0060322)2.65576347
133cerebral cortex cell migration (GO:0021795)2.64516073
134calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.63737758
135hindbrain development (GO:0030902)2.62295847
136glycosphingolipid biosynthetic process (GO:0006688)2.61710043
137somite development (GO:0061053)2.61395761
138epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.61346590
139regulation of synapse assembly (GO:0051963)2.59947024
140synaptic transmission, cholinergic (GO:0007271)2.58626147
141sympathetic nervous system development (GO:0048485)2.57799208
142negative regulation of axon extension involved in axon guidance (GO:0048843)2.57351426
143G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56062272
144epithelial cilium movement (GO:0003351)2.54300606
145regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.54181635
146protein localization to cilium (GO:0061512)2.53646896
147establishment of nucleus localization (GO:0040023)2.53252975
148axonogenesis (GO:0007409)2.53009234
149regulation of axon extension involved in axon guidance (GO:0048841)2.51643741

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.61249180
2GBX2_23144817_ChIP-Seq_PC3_Human3.89115092
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.91794572
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.78674049
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67514921
6REST_21632747_ChIP-Seq_MESCs_Mouse2.58759054
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.44803712
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.44352700
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41474843
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41474843
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39933097
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.39463590
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28526603
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27671773
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25912331
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23429446
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22461450
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.20921243
19TAF15_26573619_Chip-Seq_HEK293_Human2.17276516
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17057489
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.09219954
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.08286927
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.05833529
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.05533897
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01336590
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01052394
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00447999
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.98589944
29IGF1R_20145208_ChIP-Seq_DFB_Human1.96827127
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85497217
31* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84593490
32AR_21572438_ChIP-Seq_LNCaP_Human1.84575771
33DROSHA_22980978_ChIP-Seq_HELA_Human1.83308022
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.82627142
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81771211
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81708199
37* SMAD4_21799915_ChIP-Seq_A2780_Human1.78092031
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76074830
39ZNF274_21170338_ChIP-Seq_K562_Hela1.72049428
40FUS_26573619_Chip-Seq_HEK293_Human1.71948166
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69426274
42* P300_19829295_ChIP-Seq_ESCs_Human1.63989168
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58995652
44RNF2_27304074_Chip-Seq_NSC_Mouse1.54056843
45* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49192214
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48384822
47* EWS_26573619_Chip-Seq_HEK293_Human1.47728967
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46716027
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46183202
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.45490105
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.44096543
52* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43187675
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42275845
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41201414
55AHR_22903824_ChIP-Seq_MCF-7_Human1.41174595
56* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40703288
57* SOX2_21211035_ChIP-Seq_LN229_Gbm1.39216257
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37607246
59STAT3_23295773_ChIP-Seq_U87_Human1.37583300
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.37062095
61* AR_25329375_ChIP-Seq_VCAP_Human1.34594929
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.34473688
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34289785
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27712586
65KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.26787179
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26154559
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24037555
68BCAT_22108803_ChIP-Seq_LS180_Human1.23818034
69* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20564237
70RING1B_27294783_Chip-Seq_ESCs_Mouse1.20088805
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17673456
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17643828
73* AR_19668381_ChIP-Seq_PC3_Human1.17316813
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16486715
75CBP_20019798_ChIP-Seq_JUKART_Human1.16486715
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16182302
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15438607
78* PIAS1_25552417_ChIP-Seq_VCAP_Human1.15343626
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14814220
80TCF4_23295773_ChIP-Seq_U87_Human1.14296315
81ER_23166858_ChIP-Seq_MCF-7_Human1.13970824
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13551776
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13455188
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13455188
85RING1B_27294783_Chip-Seq_NPCs_Mouse1.12882645
86RUNX2_22187159_ChIP-Seq_PCA_Human1.12857906
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.10541001
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10511733
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08801097
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08700321
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08411675
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.08246526
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07797620
94* JUN_21703547_ChIP-Seq_K562_Human1.06956129
95LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06382513
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06284306
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06213621
98ERG_21242973_ChIP-ChIP_JURKAT_Human1.05771821
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04906137
100MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04090709
101* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03636993
102SOX9_26525672_Chip-Seq_HEART_Mouse1.03572173
103FLI1_27457419_Chip-Seq_LIVER_Mouse1.03145499
104VDR_22108803_ChIP-Seq_LS180_Human1.03138229
105RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00859310
106SMAD3_21741376_ChIP-Seq_ESCs_Human0.99604559
107NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99228930
108* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98806669
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.98033297
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97104541
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96974585
112TCF4_22108803_ChIP-Seq_LS180_Human0.96221594
113TAL1_26923725_Chip-Seq_HPCs_Mouse0.96182233
114CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.96053597
115TP53_18474530_ChIP-ChIP_U2OS_Human0.95415525
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.94827974
117KDM2B_26808549_Chip-Seq_REH_Human0.93672619
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93529265
119ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93003316
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92302056
121OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92233062
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92163396

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia4.74992369
2MP0004859_abnormal_synaptic_plasticity4.73819865
3MP0002735_abnormal_chemical_nociception4.18778331
4MP0003880_abnormal_central_pattern3.65605370
5MP0001968_abnormal_touch/_nociception3.50624204
6MP0006276_abnormal_autonomic_nervous3.47111276
7MP0002734_abnormal_mechanical_nocicepti3.33960669
8MP0003635_abnormal_synaptic_transmissio3.32407613
9MP0004858_abnormal_nervous_system2.97863006
10MP0005423_abnormal_somatic_nervous2.96778436
11MP0002736_abnormal_nociception_after2.90255609
12MP0002063_abnormal_learning/memory/cond2.86883600
13MP0000778_abnormal_nervous_system2.71842135
14MP0002733_abnormal_thermal_nociception2.66755062
15MP0009745_abnormal_behavioral_response2.57660108
16MP0002184_abnormal_innervation2.51907948
17MP0009046_muscle_twitch2.48485628
18MP0002572_abnormal_emotion/affect_behav2.36878434
19MP0002064_seizures2.31926328
20MP0001970_abnormal_pain_threshold2.31017998
21MP0002272_abnormal_nervous_system2.09791645
22MP0004811_abnormal_neuron_physiology2.05381936
23MP0002067_abnormal_sensory_capabilities2.04033085
24MP0001984_abnormal_olfaction1.97826342
25MP0008877_abnormal_DNA_methylation1.96643463
26MP0001486_abnormal_startle_reflex1.96442747
27MP0001986_abnormal_taste_sensitivity1.91159524
28MP0006292_abnormal_olfactory_placode1.90297684
29MP0000955_abnormal_spinal_cord1.86358051
30MP0000569_abnormal_digit_pigmentation1.81609234
31MP0001440_abnormal_grooming_behavior1.80028852
32MP0002557_abnormal_social/conspecific_i1.79656772
33MP0004924_abnormal_behavior1.76312528
34MP0005386_behavior/neurological_phenoty1.76312528
35MP0005645_abnormal_hypothalamus_physiol1.72637834
36MP0003123_paternal_imprinting1.66742208
37MP0003787_abnormal_imprinting1.65736606
38MP0001188_hyperpigmentation1.64733351
39MP0002882_abnormal_neuron_morphology1.62945293
40MP0003329_amyloid_beta_deposits1.59389803
41MP0002751_abnormal_autonomic_nervous1.59188584
42MP0009780_abnormal_chondrocyte_physiolo1.57663589
43MP0003890_abnormal_embryonic-extraembry1.57405708
44MP0005394_taste/olfaction_phenotype1.51082699
45MP0005499_abnormal_olfactory_system1.51082699
46MP0004133_heterotaxia1.48671974
47MP0008569_lethality_at_weaning1.43594161
48MP0003122_maternal_imprinting1.42956852
49MP0001348_abnormal_lacrimal_gland1.32466880
50MP0002066_abnormal_motor_capabilities/c1.31484711
51MP0008789_abnormal_olfactory_epithelium1.30255356
52MP0001529_abnormal_vocalization1.30162491
53MP0001501_abnormal_sleep_pattern1.29311386
54MP0005646_abnormal_pituitary_gland1.27240043
55MP0006072_abnormal_retinal_apoptosis1.24303532
56MP0002909_abnormal_adrenal_gland1.22490106
57MP0002152_abnormal_brain_morphology1.20626922
58MP0000566_synostosis1.18969590
59MP0003879_abnormal_hair_cell1.14835825
60MP0004142_abnormal_muscle_tone1.12984262
61MP0002752_abnormal_somatic_nervous1.12665244
62MP0005253_abnormal_eye_physiology1.12013666
63MP0001905_abnormal_dopamine_level1.11250232
64MP0002234_abnormal_pharynx_morphology1.10915288
65MP0004885_abnormal_endolymph1.09455449
66MP0002822_catalepsy1.05091266
67MP0003119_abnormal_digestive_system1.04898835
68MP0000049_abnormal_middle_ear1.04869415
69MP0005195_abnormal_posterior_eye1.04857769
70MP0002229_neurodegeneration1.04360406
71MP0000015_abnormal_ear_pigmentation1.03680149
72MP0003938_abnormal_ear_development1.00217671
73MP0003633_abnormal_nervous_system0.98582163
74MP0004742_abnormal_vestibular_system0.97084491
75MP0003861_abnormal_nervous_system0.96578704
76MP0010386_abnormal_urinary_bladder0.95464943
77MP0000631_abnormal_neuroendocrine_gland0.95058321
78MP0002938_white_spotting0.94270974
79MP0001502_abnormal_circadian_rhythm0.91039086
80MP0003011_delayed_dark_adaptation0.90693802
81MP0003942_abnormal_urinary_system0.90578854
82MP0002233_abnormal_nose_morphology0.90296306
83MP0003937_abnormal_limbs/digits/tail_de0.90216312
84MP0003634_abnormal_glial_cell0.90011231
85MP0003631_nervous_system_phenotype0.89960749
86MP0000751_myopathy0.89082432
87MP0004085_abnormal_heartbeat0.88299747
88MP0001963_abnormal_hearing_physiology0.86822887
89MP0002928_abnormal_bile_duct0.86535645
90MP0002069_abnormal_eating/drinking_beha0.85032931
91MP0001299_abnormal_eye_distance/0.82441579
92MP0001293_anophthalmia0.81320372
93MP0003755_abnormal_palate_morphology0.81265751
94MP0003385_abnormal_body_wall0.80689888
95MP0000372_irregular_coat_pigmentation0.76029688
96MP0005551_abnormal_eye_electrophysiolog0.74887246
97MP0003121_genomic_imprinting0.73872861
98MP0002876_abnormal_thyroid_physiology0.73522810
99MP0005391_vision/eye_phenotype0.70440692
100MP0001286_abnormal_eye_development0.69971245
101MP0000427_abnormal_hair_cycle0.68966720
102MP0002160_abnormal_reproductive_system0.68415992
103MP0000026_abnormal_inner_ear0.68394075
104MP0001485_abnormal_pinna_reflex0.65783267
105MP0005187_abnormal_penis_morphology0.64370998
106MP0001943_abnormal_respiration0.63605025
107MP0002102_abnormal_ear_morphology0.62757374
108MP0001177_atelectasis0.62623944
109MP0000534_abnormal_ureter_morphology0.62569637
110MP0002837_dystrophic_cardiac_calcinosis0.61820655
111MP0003632_abnormal_nervous_system0.61739225
112MP0008872_abnormal_physiological_respon0.60889184
113MP0003137_abnormal_impulse_conducting0.60576240
114MP0000604_amyloidosis0.59455386
115MP0010770_preweaning_lethality0.59422627
116MP0002082_postnatal_lethality0.59422627
117MP0004145_abnormal_muscle_electrophysio0.58979332
118MP0002081_perinatal_lethality0.57992887
119MP0010769_abnormal_survival0.57803471
120MP0004147_increased_porphyrin_level0.57656783
121MP0000537_abnormal_urethra_morphology0.56338839
122MP0002653_abnormal_ependyma_morphology0.55792594
123MP0010768_mortality/aging0.53832739
124MP0005535_abnormal_body_temperature0.50527466
125MP0008874_decreased_physiological_sensi0.48687802
126MP0002638_abnormal_pupillary_reflex0.48580845

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.44535110
2Focal motor seizures (HP:0011153)4.81265804
3Focal seizures (HP:0007359)4.44528916
4Febrile seizures (HP:0002373)4.18241166
5Epileptic encephalopathy (HP:0200134)4.09768225
6Atonic seizures (HP:0010819)4.02623705
7Progressive cerebellar ataxia (HP:0002073)3.94126846
8Ankle clonus (HP:0011448)3.79519420
9Abnormality of the corticospinal tract (HP:0002492)3.72155986
10Visual hallucinations (HP:0002367)3.65725319
11Action tremor (HP:0002345)3.65643360
12Termporal pattern (HP:0011008)3.65299165
13Insidious onset (HP:0003587)3.65299165
14Supranuclear gaze palsy (HP:0000605)3.65272948
15Abnormality of the labia minora (HP:0012880)3.65133943
16Limb dystonia (HP:0002451)3.40844094
17Ulnar claw (HP:0001178)3.36933965
18Mutism (HP:0002300)3.35525860
19Pheochromocytoma (HP:0002666)3.29352562
20Akinesia (HP:0002304)3.22933429
21Hyperventilation (HP:0002883)3.22839499
22Molar tooth sign on MRI (HP:0002419)3.19114073
23Abnormality of midbrain morphology (HP:0002418)3.19114073
24Absence seizures (HP:0002121)3.16095386
25Urinary bladder sphincter dysfunction (HP:0002839)3.10810291
26Amyotrophic lateral sclerosis (HP:0007354)3.08627180
27Hypothermia (HP:0002045)3.06428532
28Pancreatic fibrosis (HP:0100732)3.04111635
29True hermaphroditism (HP:0010459)2.99208335
30Urinary urgency (HP:0000012)2.94092744
31Nephronophthisis (HP:0000090)2.92236174
32Aplasia/Hypoplasia of the brainstem (HP:0007362)2.91067706
33Hypoplasia of the brainstem (HP:0002365)2.91067706
34Drooling (HP:0002307)2.90723935
35Excessive salivation (HP:0003781)2.90723935
36Amblyopia (HP:0000646)2.90237609
37Generalized tonic-clonic seizures (HP:0002069)2.89013621
38Hepatoblastoma (HP:0002884)2.85564915
39Polyphagia (HP:0002591)2.84769604
40Fetal akinesia sequence (HP:0001989)2.84181964
41Broad-based gait (HP:0002136)2.83789654
42Neuroendocrine neoplasm (HP:0100634)2.83723093
43Dialeptic seizures (HP:0011146)2.81118093
44Pancreatic cysts (HP:0001737)2.79466896
45Gait imbalance (HP:0002141)2.77478172
46Medial flaring of the eyebrow (HP:0010747)2.76349719
47Truncal ataxia (HP:0002078)2.75220142
48Spastic gait (HP:0002064)2.75198940
49Impaired vibration sensation in the lower limbs (HP:0002166)2.67766087
50Abnormal eating behavior (HP:0100738)2.67734573
51Abnormality of pain sensation (HP:0010832)2.63283581
52Impaired pain sensation (HP:0007328)2.63283581
53Lower limb muscle weakness (HP:0007340)2.50463501
54Genetic anticipation (HP:0003743)2.49737248
55Poor eye contact (HP:0000817)2.46887110
56Failure to thrive in infancy (HP:0001531)2.45217781
57Agitation (HP:0000713)2.45150744
58Progressive inability to walk (HP:0002505)2.45083127
59Aqueductal stenosis (HP:0002410)2.44000917
60Lissencephaly (HP:0001339)2.43752033
61Volvulus (HP:0002580)2.42854121
62Abnormal hair whorl (HP:0010721)2.41611836
63Genital tract atresia (HP:0001827)2.41088261
64Abnormality of the lower motor neuron (HP:0002366)2.40302936
65Epileptiform EEG discharges (HP:0011182)2.40028836
66Abnormality of the renal medulla (HP:0100957)2.39841623
67EEG with generalized epileptiform discharges (HP:0011198)2.38167798
68Vaginal atresia (HP:0000148)2.37228292
69Narrow forehead (HP:0000341)2.34671847
70Morphological abnormality of the pyramidal tract (HP:0002062)2.34289448
71Hypsarrhythmia (HP:0002521)2.33123540
72Degeneration of the lateral corticospinal tracts (HP:0002314)2.32882704
73Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.32882704
74Inability to walk (HP:0002540)2.31388850
75Depression (HP:0000716)2.28765384
76Abnormal social behavior (HP:0012433)2.26078354
77Impaired social interactions (HP:0000735)2.26078354
78Thyroid carcinoma (HP:0002890)2.24458070
79Pachygyria (HP:0001302)2.23979715
80Shawl scrotum (HP:0000049)2.23268974
81Gaze-evoked nystagmus (HP:0000640)2.23117604
82Papilledema (HP:0001085)2.22549091
83Exotropia (HP:0000577)2.22378950
84Bradycardia (HP:0001662)2.21834569
85Absent speech (HP:0001344)2.21650059
86Specific learning disability (HP:0001328)2.20622650
87Inappropriate behavior (HP:0000719)2.18930804
88Oligodactyly (hands) (HP:0001180)2.18909304
89Torticollis (HP:0000473)2.17884418
90Chronic hepatic failure (HP:0100626)2.17204203
91Retinal dysplasia (HP:0007973)2.17200005
92Cortical dysplasia (HP:0002539)2.16327038
93Cystic liver disease (HP:0006706)2.16059962
94Paraplegia (HP:0010550)2.14672152
95Hypoventilation (HP:0002791)2.11574359
96Intestinal atresia (HP:0011100)2.11316622
97Anencephaly (HP:0002323)2.10028688
98Pendular nystagmus (HP:0012043)2.09137521
99Type II lissencephaly (HP:0007260)2.07648478
100Labial hypoplasia (HP:0000066)2.06633750
101Protruding tongue (HP:0010808)2.05028425
102Abnormality of salivation (HP:0100755)2.03555863
103Renal hypoplasia (HP:0000089)2.02300898
104Rib fusion (HP:0000902)2.02248345
105Optic nerve hypoplasia (HP:0000609)2.01728532
106Postaxial hand polydactyly (HP:0001162)2.01150724
107Apathy (HP:0000741)2.00520486
108Anxiety (HP:0000739)2.00082155
109Spastic paraplegia (HP:0001258)1.98404189
110Spastic tetraplegia (HP:0002510)1.98326473
111Megalencephaly (HP:0001355)1.96801717
112Esotropia (HP:0000565)1.95204130
113Stereotypic behavior (HP:0000733)1.94767496
114Sclerocornea (HP:0000647)1.94247566
115Focal dystonia (HP:0004373)1.92638988
116Poor coordination (HP:0002370)1.92074878
117Scanning speech (HP:0002168)1.91815336
118Steppage gait (HP:0003376)1.91240105
119Papillary thyroid carcinoma (HP:0002895)1.90478297
120Dysdiadochokinesis (HP:0002075)1.90295240
121Hypoplastic female external genitalia (HP:0012815)1.88926669
122Bradykinesia (HP:0002067)1.87455445
123Sleep apnea (HP:0010535)1.87287600
124Postural instability (HP:0002172)1.87058003
125Hemiparesis (HP:0001269)1.86774565
126Congenital primary aphakia (HP:0007707)1.84955714
127Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.84571244
128Intellectual disability, severe (HP:0010864)1.84179200
129Neoplasm of the peripheral nervous system (HP:0100007)1.84000702
130Growth hormone deficiency (HP:0000824)1.83588059
131Aplasia/Hypoplasia of the sternum (HP:0006714)1.83180865
132Hip dysplasia (HP:0001385)1.82643016
133Polymicrogyria (HP:0002126)1.82500962
134Bony spicule pigmentary retinopathy (HP:0007737)1.81719165
135Micropenis (HP:0000054)1.81635138
136Neurofibrillary tangles (HP:0002185)1.80819945
137Hammertoe (HP:0001765)1.80702858
138Craniofacial dystonia (HP:0012179)1.80580356
139Cerebral inclusion bodies (HP:0100314)1.80124965
140Blue irides (HP:0000635)1.80117004
141Poor suck (HP:0002033)1.79994398
142Congenital stationary night blindness (HP:0007642)1.78497257
143Lower limb amyotrophy (HP:0007210)1.78298055
144Nephrogenic diabetes insipidus (HP:0009806)1.78067406
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.77995981
146Tented upper lip vermilion (HP:0010804)1.77782950
147Neoplasm of the adrenal cortex (HP:0100641)1.75753638
148Patellar aplasia (HP:0006443)1.73599401
149Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72087436
150Cutaneous finger syndactyly (HP:0010554)1.70433103
151Postaxial foot polydactyly (HP:0001830)1.70015635
152Short 4th metacarpal (HP:0010044)1.68619177

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.27554614
2CASK3.95796001
3NTRK33.49069987
4MAP3K42.85964868
5MAP3K92.84222004
6MAP2K72.84115075
7* MINK12.62142858
8MAPK132.57020278
9DYRK22.19980560
10LATS22.10239008
11MAP4K22.06535278
12NTRK22.00731117
13PHKG22.00219738
14PHKG12.00219738
15MAP3K121.96561685
16ERBB31.93198556
17FRK1.85703571
18PINK11.82927441
19NTRK11.82368767
20MAP2K41.76271296
21DAPK21.73821689
22TRIM281.65915241
23PAK61.61260234
24KSR11.59984251
25SGK21.59378593
26SIK31.57365498
27PLK21.51630977
28SGK4941.48952620
29SGK2231.48952620
30PRPF4B1.48132352
31LIMK11.30866218
32CDK51.30394152
33EPHA41.29519027
34LMTK21.26202598
35RPS6KA21.15061881
36PRKCG1.14957094
37CSNK1G21.13524058
38SCYL21.10540845
39SGK31.09870550
40KSR21.08049635
41AKT31.07962110
42DAPK11.07021174
43WNK41.02080021
44TNIK1.01166281
45GRK50.99708453
46NUAK10.97465382
47CAMKK10.96236675
48DYRK30.95492604
49UHMK10.95114996
50BCR0.95114410
51SIK20.93219061
52CAMK1G0.93192891
53MKNK20.90078792
54GRK10.85781293
55RET0.84629519
56CDK180.79752287
57CDK140.78052874
58MAP3K20.78033552
59PNCK0.76733477
60TYRO30.76680102
61CAMK2A0.75525400
62DYRK1A0.75358163
63WNK30.74180166
64PAK30.72629228
65INSRR0.71383763
66PRKCH0.70880232
67STK160.70282628
68CSNK1G30.69610656
69STK390.69538455
70CDK150.68888942
71CDK190.68762852
72MAP2K10.68634121
73MARK20.67451133
74MAP2K60.66975868
75FER0.65878463
76PRKCE0.63879680
77PRKCZ0.63794121
78CAMKK20.61981410
79BMPR1B0.60889252
80EPHB20.59182483
81ADRBK10.58998575
82YES10.58560245
83CAMK1D0.58331777
84CDK11A0.57968143
85GRK70.56133048
86CSNK1A1L0.55630526
87CAMK10.53471242
88FGFR20.52583670
89PKN10.52105765
90PRKD30.51875953
91CCNB10.50265559
92DYRK1B0.48317794
93WNK10.47990011
94SGK10.47320067
95* CSNK1E0.47303010
96CAMK40.46559807
97PRKACA0.46283767
98RPS6KB10.45055344
99CSNK1D0.44283822
100CSNK1A10.43542333
101ROCK10.43237747
102STK240.42485993
103ARAF0.39667736
104MAP3K60.39565181
105CAMK2B0.37342710
106EPHA30.37097248
107STK380.36067764
108STK110.35961967
109PRKAA10.35862579
110ZAK0.35504511
111BMPR20.35292183
112PLK40.35057096
113* PRKG10.35021577
114* MAPK80.34448425
115ERBB20.34199149
116MATK0.33600837
117MAPK90.32843007
118ROCK20.31714628
119DMPK0.31268459
120PRKACB0.31199903
121CSNK1G10.30802115
122PLK30.29932747
123OXSR10.29839981
124MAPKAPK30.29772899
125CDK30.29546310
126MAPK100.29388943
127* RPS6KA30.29274153
128FYN0.28624255
129BRAF0.28605335
130* GSK3B0.28505747
131ADRBK20.28248725
132* PRKDC0.28199463
133AURKA0.27850125
134MAPK120.27592287

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.50854116
2Nicotine addiction_Homo sapiens_hsa050333.09208936
3Olfactory transduction_Homo sapiens_hsa047402.86797484
4Circadian entrainment_Homo sapiens_hsa047132.43715434
5Dopaminergic synapse_Homo sapiens_hsa047282.37548325
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.36933459
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.35289232
8Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.35047424
9GABAergic synapse_Homo sapiens_hsa047272.33270438
10Long-term potentiation_Homo sapiens_hsa047202.19335302
11Glutamatergic synapse_Homo sapiens_hsa047242.16806625
12Morphine addiction_Homo sapiens_hsa050322.14188284
13Taste transduction_Homo sapiens_hsa047422.06902043
14Cholinergic synapse_Homo sapiens_hsa047252.00187999
15Amphetamine addiction_Homo sapiens_hsa050311.93480061
16Serotonergic synapse_Homo sapiens_hsa047261.93460837
17Axon guidance_Homo sapiens_hsa043601.92167714
18Insulin secretion_Homo sapiens_hsa049111.87619558
19Steroid biosynthesis_Homo sapiens_hsa001001.78719152
20Phototransduction_Homo sapiens_hsa047441.57707284
21Salivary secretion_Homo sapiens_hsa049701.57117118
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56291531
23Protein export_Homo sapiens_hsa030601.49207608
24Long-term depression_Homo sapiens_hsa047301.47618929
25Butanoate metabolism_Homo sapiens_hsa006501.46527982
26Renin secretion_Homo sapiens_hsa049241.44145741
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43838696
28Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.43776991
29Oxidative phosphorylation_Homo sapiens_hsa001901.42566779
30Cocaine addiction_Homo sapiens_hsa050301.42216570
31Gastric acid secretion_Homo sapiens_hsa049711.41200654
32Gap junction_Homo sapiens_hsa045401.40971299
33ErbB signaling pathway_Homo sapiens_hsa040121.40461278
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40447642
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36897184
36Collecting duct acid secretion_Homo sapiens_hsa049661.36598645
37Parkinsons disease_Homo sapiens_hsa050121.36333141
38GnRH signaling pathway_Homo sapiens_hsa049121.31577579
39Endometrial cancer_Homo sapiens_hsa052131.31568294
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31445584
41Oxytocin signaling pathway_Homo sapiens_hsa049211.30209880
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24183401
43Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.20393319
44Glioma_Homo sapiens_hsa052141.17439173
45Calcium signaling pathway_Homo sapiens_hsa040201.15491397
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14932646
47Basal cell carcinoma_Homo sapiens_hsa052171.14900055
48Melanogenesis_Homo sapiens_hsa049161.10889240
49Type II diabetes mellitus_Homo sapiens_hsa049301.10226897
50Estrogen signaling pathway_Homo sapiens_hsa049151.10072413
51Neurotrophin signaling pathway_Homo sapiens_hsa047221.08864235
52Oocyte meiosis_Homo sapiens_hsa041141.07955917
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04166423
54cAMP signaling pathway_Homo sapiens_hsa040241.01069608
55Vibrio cholerae infection_Homo sapiens_hsa051100.99249908
56Propanoate metabolism_Homo sapiens_hsa006400.97369354
57Linoleic acid metabolism_Homo sapiens_hsa005910.96112823
58Ether lipid metabolism_Homo sapiens_hsa005650.96110375
59Basal transcription factors_Homo sapiens_hsa030220.95987292
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95981052
61Colorectal cancer_Homo sapiens_hsa052100.94546711
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93801887
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93498685
64Huntingtons disease_Homo sapiens_hsa050160.87498948
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81930849
66Dorso-ventral axis formation_Homo sapiens_hsa043200.81344243
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80383726
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79975192
69MAPK signaling pathway_Homo sapiens_hsa040100.79695399
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76610685
71Ras signaling pathway_Homo sapiens_hsa040140.75964004
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75488874
73Insulin signaling pathway_Homo sapiens_hsa049100.74546035
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70423228
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.69102426
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68825514
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67769340
78Alcoholism_Homo sapiens_hsa050340.67475930
79Wnt signaling pathway_Homo sapiens_hsa043100.65597346
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64928535
81Choline metabolism in cancer_Homo sapiens_hsa052310.64243903
82Fanconi anemia pathway_Homo sapiens_hsa034600.63786627
83Cardiac muscle contraction_Homo sapiens_hsa042600.62733270
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62206756
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61781563
86Melanoma_Homo sapiens_hsa052180.61778284
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60706103
88Prolactin signaling pathway_Homo sapiens_hsa049170.59622499
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.59014947
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58436893
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.56824159
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56549888
93Renal cell carcinoma_Homo sapiens_hsa052110.56504095
94Glucagon signaling pathway_Homo sapiens_hsa049220.56112144
95Rap1 signaling pathway_Homo sapiens_hsa040150.54929701
96Endocytosis_Homo sapiens_hsa041440.54813347
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.54118969
98Ovarian steroidogenesis_Homo sapiens_hsa049130.53475157
99Thyroid hormone synthesis_Homo sapiens_hsa049180.53372170
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53259939
101Phagosome_Homo sapiens_hsa041450.53225977
102VEGF signaling pathway_Homo sapiens_hsa043700.51645915
103mTOR signaling pathway_Homo sapiens_hsa041500.51365514
104Hedgehog signaling pathway_Homo sapiens_hsa043400.51282628
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51014668
106Tryptophan metabolism_Homo sapiens_hsa003800.50884163
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50822166
108Selenocompound metabolism_Homo sapiens_hsa004500.50429532
109Prion diseases_Homo sapiens_hsa050200.49417407
110Dilated cardiomyopathy_Homo sapiens_hsa054140.48376445
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47402182
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47394790
113Nitrogen metabolism_Homo sapiens_hsa009100.47021350
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45339470
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44895619
116Regulation of autophagy_Homo sapiens_hsa041400.42829221
117Peroxisome_Homo sapiens_hsa041460.41061079
118Hippo signaling pathway_Homo sapiens_hsa043900.40633558
119Glycerolipid metabolism_Homo sapiens_hsa005610.40223877
120Non-small cell lung cancer_Homo sapiens_hsa052230.40131906
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39699724
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.39584059
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38750878
124Pancreatic secretion_Homo sapiens_hsa049720.37849062
125beta-Alanine metabolism_Homo sapiens_hsa004100.37745675
126Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36139962
127Fatty acid metabolism_Homo sapiens_hsa012120.35806069
128Non-homologous end-joining_Homo sapiens_hsa034500.35609022
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35520432
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34840826
131RNA degradation_Homo sapiens_hsa030180.34118560
132Salmonella infection_Homo sapiens_hsa051320.34115953
133Alzheimers disease_Homo sapiens_hsa050100.32341933
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30821696

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