MAP1LC3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)6.79680993
2purine nucleobase biosynthetic process (GO:0009113)6.31799948
3ribosome assembly (GO:0042255)6.07490503
4transcription elongation from RNA polymerase III promoter (GO:0006385)5.66048105
5termination of RNA polymerase III transcription (GO:0006386)5.66048105
6nucleobase biosynthetic process (GO:0046112)5.37538955
7rRNA modification (GO:0000154)5.29011614
8DNA deamination (GO:0045006)5.20726791
9positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)5.20459763
10negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)5.12917187
117-methylguanosine mRNA capping (GO:0006370)5.10014006
12amino acid salvage (GO:0043102)5.06581909
13L-methionine salvage (GO:0071267)5.06581909
14L-methionine biosynthetic process (GO:0071265)5.06581909
15regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)5.02481395
16anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:05.00942413
177-methylguanosine RNA capping (GO:0009452)4.93526567
18RNA capping (GO:0036260)4.93526567
19regulation of cellular amino acid metabolic process (GO:0006521)4.71474201
20ribosome biogenesis (GO:0042254)4.70534803
21positive regulation of ubiquitin-protein transferase activity (GO:0051443)4.66051911
22synaptic vesicle maturation (GO:0016188)4.64732092
23negative regulation of ligase activity (GO:0051352)4.57726454
24negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.57726454
25transcription elongation from RNA polymerase I promoter (GO:0006362)4.55585787
26folic acid transport (GO:0015884)4.55173231
27positive regulation of mitochondrial fission (GO:0090141)4.53803150
28transcription from RNA polymerase I promoter (GO:0006360)4.53248936
29termination of RNA polymerase I transcription (GO:0006363)4.47609695
30positive regulation of ligase activity (GO:0051351)4.38510920
31regulation of synaptic vesicle exocytosis (GO:2000300)4.34774861
32regulation of mitochondrial translation (GO:0070129)4.26042991
33L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.23747387
34signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.23361830
35signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.23361830
36signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.23361830
37signal transduction involved in DNA integrity checkpoint (GO:0072401)4.21461198
38signal transduction involved in DNA damage checkpoint (GO:0072422)4.21461198
39blastocyst development (GO:0001824)4.20445107
40signal transduction involved in cell cycle checkpoint (GO:0072395)4.17949697
41DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.17304689
42synaptic vesicle exocytosis (GO:0016079)4.17262060
43mitotic metaphase plate congression (GO:0007080)4.09762440
44signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.08480480
45intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.08480480
46folic acid metabolic process (GO:0046655)4.05299595
47lung-associated mesenchyme development (GO:0060484)4.00772663
48positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.99952719
49transcription initiation from RNA polymerase I promoter (GO:0006361)3.96822255
50regulation of ubiquitin-protein transferase activity (GO:0051438)3.96556479
51NADH metabolic process (GO:0006734)3.94918042
52glutamate secretion (GO:0014047)3.86319336
53methionine biosynthetic process (GO:0009086)3.84351248
54transcription elongation from RNA polymerase II promoter (GO:0006368)3.82265803
55regulation of synaptic vesicle transport (GO:1902803)3.78542338
56ribonucleoprotein complex biogenesis (GO:0022613)3.77197599
57regulation of ligase activity (GO:0051340)3.76450705
58formation of translation preinitiation complex (GO:0001731)3.75386822
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.72199809
60GMP metabolic process (GO:0046037)3.71095344
61intestinal epithelial cell development (GO:0060576)3.70824502
62DNA-templated transcription, elongation (GO:0006354)3.70428917
63methionine metabolic process (GO:0006555)3.63250146
64rRNA methylation (GO:0031167)3.60138117
65maturation of 5.8S rRNA (GO:0000460)3.59011417
66establishment of protein localization to mitochondrial membrane (GO:0090151)3.58753951
67positive regulation of viral transcription (GO:0050434)3.58405210
68regulation of translation in response to stress (GO:0043555)3.55793482
69guanosine-containing compound biosynthetic process (GO:1901070)3.54085678
70protein targeting to mitochondrion (GO:0006626)3.51964684
71autophagic vacuole assembly (GO:0000045)3.49749879
72regulation of G0 to G1 transition (GO:0070316)3.49640098
73maturation of SSU-rRNA (GO:0030490)3.49475659
74establishment of protein localization to mitochondrion (GO:0072655)3.48125898
75DNA replication checkpoint (GO:0000076)3.47308972
76rRNA processing (GO:0006364)3.47254498
77antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.45690185
78ribosomal large subunit biogenesis (GO:0042273)3.45438058
79regulation of cellular amine metabolic process (GO:0033238)3.45207345
80protein neddylation (GO:0045116)3.44413788
81vitamin transmembrane transport (GO:0035461)3.44106189
82spliceosomal snRNP assembly (GO:0000387)3.43996097
83cullin deneddylation (GO:0010388)3.40826003
84polyamine biosynthetic process (GO:0006596)3.40228828
85positive regulation of cell cycle arrest (GO:0071158)3.38563221
86rRNA metabolic process (GO:0016072)3.35040577
87neuronal action potential propagation (GO:0019227)3.34155720
88negative regulation of macroautophagy (GO:0016242)3.31495330
89protein localization to mitochondrion (GO:0070585)3.30732282
90response to xenobiotic stimulus (GO:0009410)3.29650838
91G1/S transition of mitotic cell cycle (GO:0000082)3.27799945
92cell cycle G1/S phase transition (GO:0044843)3.27799945
93cellular component biogenesis (GO:0044085)3.27322988
94regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.27139209
95GDP-mannose metabolic process (GO:0019673)3.27067860
96protein deneddylation (GO:0000338)3.26405829
97S-adenosylmethionine metabolic process (GO:0046500)3.25491690
98regulation of spindle organization (GO:0090224)3.23360179
99transcription-coupled nucleotide-excision repair (GO:0006283)3.20627057
100negative regulation of protein ubiquitination (GO:0031397)3.19530615
101DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.18548583
102peptidyl-histidine modification (GO:0018202)3.17987838
103chaperone-mediated protein transport (GO:0072321)3.17384139
104amino sugar catabolic process (GO:0046348)3.17146226
105pseudouridine synthesis (GO:0001522)3.14566356
106energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.12643535
107ATP hydrolysis coupled proton transport (GO:0015991)3.12643535
108pyrimidine nucleobase catabolic process (GO:0006208)3.10380609
109polyamine metabolic process (GO:0006595)3.09659128
110regulation of mitochondrial fission (GO:0090140)3.06962595
111negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.06501109
112positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.05059940
113mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.05059940
114negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04224957
115regulation of cAMP-dependent protein kinase activity (GO:2000479)3.03948314
116positive regulation of DNA-templated transcription, elongation (GO:0032786)3.03504179
117sulfur amino acid biosynthetic process (GO:0000097)3.02681301
118transcription from RNA polymerase III promoter (GO:0006383)3.01556928
119regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.00799409
120Arp2/3 complex-mediated actin nucleation (GO:0034314)2.93645346
121neurotransmitter secretion (GO:0007269)2.91064511
122negative regulation of heart rate (GO:0010459)2.90852719
123regulation of synapse structural plasticity (GO:0051823)2.89260016
124regulation of short-term neuronal synaptic plasticity (GO:0048172)2.86635248
125synaptic vesicle docking involved in exocytosis (GO:0016081)2.86477016
126COPI coating of Golgi vesicle (GO:0048205)2.84664390
127Golgi transport vesicle coating (GO:0048200)2.84664390
128transferrin transport (GO:0033572)2.82769707
129viral protein processing (GO:0019082)2.76359717
130negative regulation of cation channel activity (GO:2001258)2.74652930
131organelle transport along microtubule (GO:0072384)2.74515168
132ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.68100469
133glycerophospholipid catabolic process (GO:0046475)2.66624487
134establishment of mitochondrion localization (GO:0051654)2.64949082
135negative regulation of calcium ion transmembrane transport (GO:1903170)2.63993977
136negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.63993977
137protein localization to synapse (GO:0035418)2.63628625
138protein insertion into membrane (GO:0051205)2.60780015
139mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.56501240
140phagosome maturation (GO:0090382)2.56332655
141ferric iron transport (GO:0015682)2.54393224
142trivalent inorganic cation transport (GO:0072512)2.54393224
143negative regulation of appetite (GO:0032099)2.51550576
144negative regulation of response to food (GO:0032096)2.51550576
145intra-Golgi vesicle-mediated transport (GO:0006891)2.51392009
146vesicle docking (GO:0048278)2.50307677
147regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.49403374
148acidic amino acid transport (GO:0015800)2.48947916
149vesicle docking involved in exocytosis (GO:0006904)2.46529084
150glycosphingolipid biosynthetic process (GO:0006688)2.45553067
151protein maturation by protein folding (GO:0022417)2.44745204
152metallo-sulfur cluster assembly (GO:0031163)2.43995597
153iron-sulfur cluster assembly (GO:0016226)2.43995597
154actin nucleation (GO:0045010)2.43709764
155positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.42935923
156L-serine transport (GO:0015825)2.40805860
157neurofilament cytoskeleton organization (GO:0060052)2.40496842
158dosage compensation (GO:0007549)2.38935789
159sequestering of actin monomers (GO:0042989)2.38699340
160synaptic transmission, glutamatergic (GO:0035249)2.38124716
161negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.38076375
162gamma-aminobutyric acid transport (GO:0015812)2.37971162
163vesicle targeting (GO:0006903)2.36542311
164regulation of neurotransmitter secretion (GO:0046928)2.36489751
165nucleobase catabolic process (GO:0046113)2.35109310
166regulation of integrin-mediated signaling pathway (GO:2001044)2.34782301
167retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.34259272
168positive regulation of TOR signaling (GO:0032008)2.33697969
169neutrophil activation involved in immune response (GO:0002283)2.30171453
170neuronal ion channel clustering (GO:0045161)2.30105410
171sodium ion export (GO:0071436)2.29398483
172substantia nigra development (GO:0021762)2.28804292
173cellular biogenic amine biosynthetic process (GO:0042401)2.28703275
174response to redox state (GO:0051775)2.28383334
175melanosome transport (GO:0032402)2.28062214
176endoplasmic reticulum organization (GO:0007029)2.27761119
177negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.27681939
178pH reduction (GO:0045851)2.26394373
179dendritic spine organization (GO:0097061)2.26186411
180virion assembly (GO:0019068)2.25927681
181maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.25141589
182amino acid import (GO:0043090)2.24861660
183L-glutamate transport (GO:0015813)2.22257334
184ER overload response (GO:0006983)2.21754386
185regulation of voltage-gated calcium channel activity (GO:1901385)2.21747683
186neurotransmitter transport (GO:0006836)2.21711397
187regulation of actin nucleation (GO:0051125)2.21671913
188regulation of neurotransmitter transport (GO:0051588)2.21486864
189regulation of neurotransmitter levels (GO:0001505)2.20898434
190regulation of vacuole organization (GO:0044088)2.20714532
191growth hormone secretion (GO:0030252)2.19710864
192postsynaptic membrane organization (GO:0001941)2.19318994
193* autophagy (GO:0006914)2.18893131
194negative regulation of interleukin-17 production (GO:0032700)2.18733731
195regulation of receptor recycling (GO:0001919)2.18382757
196positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.18329654
197regulation of protein targeting to membrane (GO:0090313)2.16682671

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.53615841
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.81825318
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.58209976
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.34738590
5* ETS1_20019798_ChIP-Seq_JURKAT_Human4.26711217
6CREB1_15753290_ChIP-ChIP_HEK293T_Human4.17061703
7EST1_17652178_ChIP-ChIP_JURKAT_Human4.07465807
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.95422660
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.58575235
10EZH2_22144423_ChIP-Seq_EOC_Human3.36504656
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.26789782
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.12202250
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.01266803
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.97098877
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95176491
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.92148823
17* VDR_23849224_ChIP-Seq_CD4+_Human2.90140156
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.78365090
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.69795222
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67546090
21GBX2_23144817_ChIP-Seq_PC3_Human2.47269284
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.46625717
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.31205804
24* YY1_21170310_ChIP-Seq_MESCs_Mouse2.26151666
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.26006546
26GABP_19822575_ChIP-Seq_HepG2_Human2.25953584
27E2F7_22180533_ChIP-Seq_HELA_Human2.25939775
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23163544
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18432279
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17341218
31SRF_21415370_ChIP-Seq_HL-1_Mouse2.14910673
32* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.14313350
33XRN2_22483619_ChIP-Seq_HELA_Human2.13288177
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.12605428
35DCP1A_22483619_ChIP-Seq_HELA_Human2.12582154
36* REST_18959480_ChIP-ChIP_MESCs_Mouse2.09107084
37WT1_19549856_ChIP-ChIP_CCG9911_Human2.08320113
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.05453760
39FOXP3_21729870_ChIP-Seq_TREG_Human2.04446042
40* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.03511006
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.03022991
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98370004
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.97756476
44E2F4_17652178_ChIP-ChIP_JURKAT_Human1.97565286
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83429838
46* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78601264
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76612481
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76108392
49ELK1_22589737_ChIP-Seq_MCF10A_Human1.75798899
50* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75066832
51* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70554755
52* REST_21632747_ChIP-Seq_MESCs_Mouse1.68308386
53FOXM1_23109430_ChIP-Seq_U2OS_Human1.65417063
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.63762427
55* ELK1_19687146_ChIP-ChIP_HELA_Human1.63672648
56* TTF2_22483619_ChIP-Seq_HELA_Human1.61050954
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.60494354
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60475182
59RARB_27405468_Chip-Seq_BRAIN_Mouse1.59571848
60ZNF263_19887448_ChIP-Seq_K562_Human1.59036179
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.57386670
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56152106
63AR_21909140_ChIP-Seq_LNCAP_Human1.55873985
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.54733529
65SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.53888753
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53599571
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48228643
68KDM5A_27292631_Chip-Seq_BREAST_Human1.45748816
69MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42786870
70JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42606723
71CLOCK_20551151_ChIP-Seq_293T_Human1.41142305
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.41112793
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37402855
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36227497
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.34207209
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.32523735
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32392804
78NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.32118850
79IGF1R_20145208_ChIP-Seq_DFB_Human1.31815097
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31113330
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29742420
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29505711
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28306012
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27076830
85JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26626018
86KAP1_22055183_ChIP-Seq_ESCs_Mouse1.24742053
87NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.24702261
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23266833
89SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.22220350
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21527598
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21439812
92BP1_19119308_ChIP-ChIP_Hs578T_Human1.20283482
93MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20071874
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19912424
95SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19629427
96ELK4_26923725_Chip-Seq_MESODERM_Mouse1.18572317
97* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18170440
98GATA2_21666600_ChIP-Seq_HMVEC_Human1.17758599
99TAF15_26573619_Chip-Seq_HEK293_Human1.17593365
100KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.15712948
101FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15137301
102KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13014809
103* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12143134
104CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12055468
105NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10390602
106SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10112515
107EGR1_19032775_ChIP-ChIP_M12_Human1.08415922
108STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08349727
109* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.07487168
110* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07448172
111ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06771088
112SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06748338
113MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06560061
114* CIITA_25753668_ChIP-Seq_RAJI_Human1.06460292
115ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05390408
116CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01270178
117SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00757396
118CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.00268122
119NOTCH1_21737748_ChIP-Seq_TLL_Human0.99942743
120TP53_22573176_ChIP-Seq_HFKS_Human0.99759411
121KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99685561
122KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99685561
123KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99685561
124* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98217174
125* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97741062
126DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97316065
127SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96673956
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96655916
129* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96539990
130TET1_21490601_ChIP-Seq_MESCs_Mouse0.95370660
131SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95015806
132SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94718903
133* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.93980712
134REST_19997604_ChIP-ChIP_NEURONS_Mouse0.92647858
135EZH2_27294783_Chip-Seq_ESCs_Mouse0.91958077
136CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91515638
137SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91429641
138JARID2_20075857_ChIP-Seq_MESCs_Mouse0.90935265
139CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90592499
140SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.90376997
141NANOG_21062744_ChIP-ChIP_HESCs_Human0.89898565
142EED_16625203_ChIP-ChIP_MESCs_Mouse0.89128091
143NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88816157
144NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88816157
145* SOX17_20123909_ChIP-Seq_XEN_Mouse0.87941331
146RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87454974
147SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87423925
148SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86832674
149POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86499515
150GATA1_19941827_ChIP-Seq_MEL_Mouse0.85092826
151HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.84536108
152* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84410064
153POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84329705
154CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84263583
155* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83598614
156GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83188954
157DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82784047
158* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.82424661
159CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81776224
160ELF1_20517297_ChIP-Seq_JURKAT_Human0.81592398
161IRF1_19129219_ChIP-ChIP_H3396_Human0.81534094
162TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.80726717
163* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80578480
164HTT_18923047_ChIP-ChIP_STHdh_Human0.80450597
165PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80293086
166E2F1_21310950_ChIP-Seq_MCF-7_Human0.79990545
167OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79725004
168NR3C1_23031785_ChIP-Seq_PC12_Mouse0.79225863
169* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.78860624
170ERG_20887958_ChIP-Seq_HPC-7_Mouse0.77582482
171RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.76017750
172TFEB_21752829_ChIP-Seq_HELA_Human0.75929855
173* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.75407282
174CTBP2_25329375_ChIP-Seq_LNCAP_Human0.74900104
175DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74413272
176ZFP57_27257070_Chip-Seq_ESCs_Mouse0.74341214
177TP53_22127205_ChIP-Seq_IMR90_Human0.72519786
178GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72221569
179PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.71459296
180GATA1_26923725_Chip-Seq_HPCs_Mouse0.69342999
181PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.68458488
182ZFP281_18757296_ChIP-ChIP_E14_Mouse0.64830222
183FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.64786168
184MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.64138367
185IRF8_21731497_ChIP-ChIP_J774_Mouse0.62839450
186CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.62469151
187JARID2_20064375_ChIP-Seq_MESCs_Mouse0.62070347

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.32046829
2MP0008260_abnormal_autophagy5.65919739
3MP0003718_maternal_effect5.28264713
4MP0003111_abnormal_nucleus_morphology4.26056420
5MP0004859_abnormal_synaptic_plasticity3.89526300
6MP0004957_abnormal_blastocyst_morpholog3.83450261
7MP0003880_abnormal_central_pattern3.35509800
8MP0003786_premature_aging3.12627254
9MP0003077_abnormal_cell_cycle2.97320601
10MP0008058_abnormal_DNA_repair2.75806942
11MP0004270_analgesia2.65678262
12MP0010094_abnormal_chromosome_stability2.63765361
13MP0001542_abnormal_bone_strength2.54952730
14MP0008932_abnormal_embryonic_tissue2.39169464
15MP0005423_abnormal_somatic_nervous2.34171751
16MP0003635_abnormal_synaptic_transmissio2.22796329
17MP0008877_abnormal_DNA_methylation2.22256916
18MP0002332_abnormal_exercise_endurance2.21606723
19MP0009840_abnormal_foam_cell2.17507712
20MP0004510_myositis2.15180223
21MP0003315_abnormal_perineum_morphology2.10196171
22MP0008007_abnormal_cellular_replicative2.09645222
23MP0002064_seizures2.04886751
24MP0005395_other_phenotype2.03391335
25MP0003123_paternal_imprinting2.03021996
26MP0005464_abnormal_platelet_physiology2.02499555
27MP0001661_extended_life_span2.01128126
28MP0003878_abnormal_ear_physiology1.91451154
29MP0005377_hearing/vestibular/ear_phenot1.91451154
30MP0002063_abnormal_learning/memory/cond1.87944195
31MP0003724_increased_susceptibility_to1.87494724
32MP0009745_abnormal_behavioral_response1.80936259
33MP0003646_muscle_fatigue1.76637438
34MP0002272_abnormal_nervous_system1.76536829
35MP0001986_abnormal_taste_sensitivity1.75810754
36MP0001968_abnormal_touch/_nociception1.71655072
37MP0002572_abnormal_emotion/affect_behav1.69672591
38MP0002876_abnormal_thyroid_physiology1.67988987
39MP0008057_abnormal_DNA_replication1.63708239
40MP0003172_abnormal_lysosome_physiology1.62527307
41MP0006035_abnormal_mitochondrial_morpho1.62016778
42MP0001970_abnormal_pain_threshold1.60159605
43MP0002733_abnormal_thermal_nociception1.58167574
44MP0001730_embryonic_growth_arrest1.57683586
45MP0005499_abnormal_olfactory_system1.56622233
46MP0005394_taste/olfaction_phenotype1.56622233
47MP0004811_abnormal_neuron_physiology1.55580702
48MP0001501_abnormal_sleep_pattern1.53631819
49MP0001486_abnormal_startle_reflex1.50699420
50MP0000343_altered_response_to1.48756569
51MP0009333_abnormal_splenocyte_physiolog1.47063489
52MP0005389_reproductive_system_phenotype1.45520999
53MP0002736_abnormal_nociception_after1.45326989
54MP0001984_abnormal_olfaction1.43476506
55MP0002160_abnormal_reproductive_system1.41819906
56MP0003879_abnormal_hair_cell1.41782227
57MP0003122_maternal_imprinting1.40630524
58MP0002822_catalepsy1.40289487
59MP0003941_abnormal_skin_development1.39922241
60MP0004484_altered_response_of1.37589057
61MP0008569_lethality_at_weaning1.34998394
62MP0004142_abnormal_muscle_tone1.33599325
63MP0003221_abnormal_cardiomyocyte_apopto1.33126701
64MP0001502_abnormal_circadian_rhythm1.32349075
65MP0000604_amyloidosis1.31752852
66MP0005451_abnormal_body_composition1.30798051
67MP0003011_delayed_dark_adaptation1.30756302
68MP0001756_abnormal_urination1.30704914
69MP0004084_abnormal_cardiac_muscle1.29403524
70MP0003938_abnormal_ear_development1.29385356
71MP0005167_abnormal_blood-brain_barrier1.29194679
72MP0000750_abnormal_muscle_regeneration1.26270747
73MP0002067_abnormal_sensory_capabilities1.25374769
74MP0003633_abnormal_nervous_system1.23764902
75MP0000920_abnormal_myelination1.23671208
76MP0008004_abnormal_stomach_pH1.23509629
77MP0001905_abnormal_dopamine_level1.23420349
78MP0002210_abnormal_sex_determination1.23292781
79MP0008874_decreased_physiological_sensi1.20900053
80MP0002132_abnormal_respiratory_system1.20497861
81MP0009764_decreased_sensitivity_to1.19608837
82MP0003186_abnormal_redox_activity1.19508953
83MP0001764_abnormal_homeostasis1.15566461
84MP0000350_abnormal_cell_proliferation1.13306620
85MP0002163_abnormal_gland_morphology1.13269500
86MP0006036_abnormal_mitochondrial_physio1.12668797
87MP0003806_abnormal_nucleotide_metabolis1.12625704
88MP0005058_abnormal_lysosome_morphology1.11816922
89MP0006054_spinal_hemorrhage1.11348296
90MP0004019_abnormal_vitamin_homeostasis1.11125404
91MP0000358_abnormal_cell_content/1.10474635
92MP0001672_abnormal_embryogenesis/_devel1.08916885
93MP0005380_embryogenesis_phenotype1.08916885
94MP0002229_neurodegeneration1.07405157
95MP0001145_abnormal_male_reproductive1.06628686
96MP0001727_abnormal_embryo_implantation1.06296841
97MP0003136_yellow_coat_color1.05613375
98MP0004924_abnormal_behavior1.05094127
99MP0005386_behavior/neurological_phenoty1.05094127
100MP0001919_abnormal_reproductive_system1.04519448
101MP0003567_abnormal_fetal_cardiomyocyte1.04257428
102MP0002396_abnormal_hematopoietic_system1.03058031
103MP0002295_abnormal_pulmonary_circulatio1.01573806
104MP0005083_abnormal_biliary_tract1.01528901
105MP0002080_prenatal_lethality1.01253942
106MP0001929_abnormal_gametogenesis1.01195798
107MP0002066_abnormal_motor_capabilities/c1.00789720
108MP0005535_abnormal_body_temperature1.00468902
109MP0000749_muscle_degeneration0.99947962
110MP0003075_altered_response_to0.99728099
111MP0002557_abnormal_social/conspecific_i0.98888611
112MP0000465_gastrointestinal_hemorrhage0.97153429
113MP0003303_peritoneal_inflammation0.96270749
114MP0006082_CNS_inflammation0.95458773
115MP0000653_abnormal_sex_gland0.95166594
116MP0002882_abnormal_neuron_morphology0.94927187
117MP0003631_nervous_system_phenotype0.94789216
118MP0000372_irregular_coat_pigmentation0.92852209
119MP0000647_abnormal_sebaceous_gland0.91944517
120MP0004215_abnormal_myocardial_fiber0.91730117
121MP0002972_abnormal_cardiac_muscle0.90611298
122MP0000747_muscle_weakness0.90305820
123MP0002653_abnormal_ependyma_morphology0.90172710
124MP0003984_embryonic_growth_retardation0.89994405
125MP0003690_abnormal_glial_cell0.89615584
126MP0001529_abnormal_vocalization0.89564797
127MP0003191_abnormal_cellular_cholesterol0.88978005
128MP0005084_abnormal_gallbladder_morpholo0.88635353
129MP0002088_abnormal_embryonic_growth/wei0.86753443
130MP0000313_abnormal_cell_death0.85609287
131MP0005332_abnormal_amino_acid0.85514508
132MP0008789_abnormal_olfactory_epithelium0.84874046
133MP0003329_amyloid_beta_deposits0.83720993
134MP0002102_abnormal_ear_morphology0.83083899
135MP0003828_pulmonary_edema0.82179861
136MP0003656_abnormal_erythrocyte_physiolo0.82038119
137MP0005384_cellular_phenotype0.81717463
138MP0000627_abnormal_mammary_gland0.81053112
139MP0000955_abnormal_spinal_cord0.79735543
140MP0009697_abnormal_copulation0.79592588
141MP0000778_abnormal_nervous_system0.78816898
142MP0001697_abnormal_embryo_size0.78783670
143MP0001188_hyperpigmentation0.78732201
144MP0005621_abnormal_cell_physiology0.78709319
145MP0001440_abnormal_grooming_behavior0.77145301
146MP0002909_abnormal_adrenal_gland0.76296542
147MP0009046_muscle_twitch0.76234329
148MP0005620_abnormal_muscle_contractility0.75824406
149MP0002734_abnormal_mechanical_nocicepti0.75266681
150MP0005410_abnormal_fertilization0.74845766
151MP0001485_abnormal_pinna_reflex0.74074563
152MP0002269_muscular_atrophy0.70099333
153MP0001119_abnormal_female_reproductive0.69494343
154MP0003634_abnormal_glial_cell0.69429908
155MP0009763_increased_sensitivity_to0.68966684
156MP0005646_abnormal_pituitary_gland0.68900112
157MP0005164_abnormal_response_to0.68843378
158MP0000751_myopathy0.68713829
159MP0003279_aneurysm0.68476965
160MP0002735_abnormal_chemical_nociception0.67734259
161MP0005397_hematopoietic_system_phenotyp0.67553950
162MP0001545_abnormal_hematopoietic_system0.67553950
163MP0002277_abnormal_respiratory_mucosa0.67283815
164MP0009672_abnormal_birth_weight0.67082947
165MP0000681_abnormal_thyroid_gland0.66654392
166MP0005670_abnormal_white_adipose0.66454746
167MP0003698_abnormal_male_reproductive0.64290383
168MP0003699_abnormal_female_reproductive0.63794387
169MP0006292_abnormal_olfactory_placode0.61363837
170MP0002161_abnormal_fertility/fecundity0.61244781
171MP0005075_abnormal_melanosome_morpholog0.60314554
172MP0003195_calcinosis0.58675133
173MP0008995_early_reproductive_senescence0.58259016
174MP0002085_abnormal_embryonic_tissue0.57664275
175MP0003936_abnormal_reproductive_system0.56931528
176MP0004147_increased_porphyrin_level0.55409511
177MP0006276_abnormal_autonomic_nervous0.54874055

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)5.52568041
2Breast hypoplasia (HP:0003187)5.06505412
3Upper limb muscle weakness (HP:0003484)4.82757925
4Polyphagia (HP:0002591)4.80732672
5Birth length less than 3rd percentile (HP:0003561)4.72561354
6Carpal bone hypoplasia (HP:0001498)4.66309382
7Hyperglycinemia (HP:0002154)4.28139144
8Rough bone trabeculation (HP:0100670)4.25382929
9Myokymia (HP:0002411)3.71626584
10Abnormality of alanine metabolism (HP:0010916)3.71292205
11Hyperalaninemia (HP:0003348)3.71292205
12Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.71292205
13Mutism (HP:0002300)3.69626349
14Abnormal eating behavior (HP:0100738)3.62284729
15Hand muscle atrophy (HP:0009130)3.53050581
16Secondary amenorrhea (HP:0000869)3.45808427
17Hyperglycinuria (HP:0003108)3.45788253
18Ankle clonus (HP:0011448)3.33282220
19Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.33225323
20CNS hypomyelination (HP:0003429)3.32768462
21Impulsivity (HP:0100710)3.32245809
22Supranuclear gaze palsy (HP:0000605)3.28334786
23Aplasia/Hypoplasia involving the musculature (HP:0001460)3.24925605
24Aplasia/Hypoplasia of the patella (HP:0006498)3.23734829
25Abnormality of the umbilical cord (HP:0010881)3.21036036
26Delusions (HP:0000746)3.18955425
27Tetraparesis (HP:0002273)3.13356027
28Patellar aplasia (HP:0006443)3.13275302
29Abnormal trabecular bone morphology (HP:0100671)3.12264482
30Diplopia (HP:0000651)3.11695419
31Abnormality of binocular vision (HP:0011514)3.11695419
32Progressive muscle weakness (HP:0003323)3.06493103
33Abnormality of glycolipid metabolism (HP:0010969)3.05649548
34Abnormality of liposaccharide metabolism (HP:0010968)3.05649548
35Abnormality of glycosphingolipid metabolism (HP:0004343)3.05649548
36Gout (HP:0001997)3.03723862
37Ureteral duplication (HP:0000073)3.00348124
38Distal upper limb amyotrophy (HP:0007149)2.94428753
39Upper limb amyotrophy (HP:0009129)2.94428753
40Atonic seizures (HP:0010819)2.93574386
41Spastic gait (HP:0002064)2.93469501
423-Methylglutaconic aciduria (HP:0003535)2.92397283
43Premature ovarian failure (HP:0008209)2.89312816
44Exercise-induced muscle cramps (HP:0003710)2.89176218
45Failure to thrive in infancy (HP:0001531)2.85740405
46Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.84152182
47Death in infancy (HP:0001522)2.82445792
48Limb dystonia (HP:0002451)2.82244725
49Neuronal loss in central nervous system (HP:0002529)2.81256236
50Petechiae (HP:0000967)2.76723329
51Abnormality of glycine metabolism (HP:0010895)2.76427967
52Abnormality of serine family amino acid metabolism (HP:0010894)2.76427967
53Abnormal gallbladder physiology (HP:0012438)2.76217196
54Cholecystitis (HP:0001082)2.76217196
55Abnormality of serum amino acid levels (HP:0003112)2.75677192
56Neurofibrillary tangles (HP:0002185)2.73840219
57Degeneration of anterior horn cells (HP:0002398)2.72910131
58Abnormality of the anterior horn cell (HP:0006802)2.72910131
59Glucose intolerance (HP:0000833)2.72639716
60Areflexia of lower limbs (HP:0002522)2.72106933
61Multiple enchondromatosis (HP:0005701)2.71559288
62Prolonged neonatal jaundice (HP:0006579)2.69614578
63Entropion (HP:0000621)2.68806970
64CNS demyelination (HP:0007305)2.68445072
65Dysautonomia (HP:0002459)2.67683959
66Loss of speech (HP:0002371)2.62677815
67Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.60881385
68Decreased activity of mitochondrial respiratory chain (HP:0008972)2.60255970
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.60255970
70Sparse eyelashes (HP:0000653)2.59864768
71Atrioventricular block (HP:0001678)2.56796859
72Testicular atrophy (HP:0000029)2.53540403
73Abnormal spermatogenesis (HP:0008669)2.53439802
74Congenital, generalized hypertrichosis (HP:0004540)2.51118902
75Progressive external ophthalmoplegia (HP:0000590)2.50822471
76Febrile seizures (HP:0002373)2.50229681
77Lower limb muscle weakness (HP:0007340)2.49185288
78Patent foramen ovale (HP:0001655)2.46597449
79Ventricular fibrillation (HP:0001663)2.46454818
80Absent hand (HP:0004050)2.46285352
81Irregular epiphyses (HP:0010582)2.45793383
82Epileptic encephalopathy (HP:0200134)2.45755748
83Aplasia/hypoplasia of the uterus (HP:0008684)2.43420232
84Prolonged bleeding time (HP:0003010)2.42768690
85Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.41419470
86Unsteady gait (HP:0002317)2.39494115
87Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.38711736
88Bundle branch block (HP:0011710)2.37685935
89Purpura (HP:0000979)2.37376325
90Muscle fiber splitting (HP:0003555)2.36142294
91Absent radius (HP:0003974)2.35986185
92Abnormalities of placenta or umbilical cord (HP:0001194)2.35545732
93Abnormality of the labia minora (HP:0012880)2.35133165
94Gait imbalance (HP:0002141)2.33492090
95Spastic tetraplegia (HP:0002510)2.32900790
96Menorrhagia (HP:0000132)2.31885453
97External ophthalmoplegia (HP:0000544)2.30929944
98Peripheral hypomyelination (HP:0007182)2.30022830
99Postnatal microcephaly (HP:0005484)2.29515824
100Microretrognathia (HP:0000308)2.29286220
101Focal motor seizures (HP:0011153)2.29044777
102Hypoplasia of the capital femoral epiphysis (HP:0003090)2.28892359
103Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.28573207
104Focal dystonia (HP:0004373)2.27132544
105Hepatic necrosis (HP:0002605)2.26250029
106Hepatocellular necrosis (HP:0001404)2.25149647
107Amyotrophic lateral sclerosis (HP:0007354)2.24151319
108Megaloblastic anemia (HP:0001889)2.23795696
109Torticollis (HP:0000473)2.23610843
110Diminished motivation (HP:0000745)2.22961091
111Increased serum lactate (HP:0002151)2.22240360
112Action tremor (HP:0002345)2.21728900
113Personality changes (HP:0000751)2.21524392
114Aplasia involving forearm bones (HP:0009822)2.21354341
115Absent forearm bone (HP:0003953)2.21354341
116Pancreatic fibrosis (HP:0100732)2.21242285
117Atrophy/Degeneration involving motor neurons (HP:0007373)2.21227601
118Hypsarrhythmia (HP:0002521)2.20878471
119Autoamputation (HP:0001218)2.20460991
120Tongue fasciculations (HP:0001308)2.20354315
121EEG with generalized epileptiform discharges (HP:0011198)2.18362063
122Craniofacial dystonia (HP:0012179)2.15666468
123Epileptiform EEG discharges (HP:0011182)2.15399802
124Abnormality of glycolysis (HP:0004366)2.15274054
125Increased serum pyruvate (HP:0003542)2.15274054
126Split foot (HP:0001839)2.14852300
127Medial flaring of the eyebrow (HP:0010747)2.14550722
128Tetraplegia (HP:0002445)2.11482466
129Type 2 muscle fiber atrophy (HP:0003554)2.10676504
130Segmental peripheral demyelination/remyelination (HP:0003481)2.10612561
131Myoglobinuria (HP:0002913)2.08917889
132Rapidly progressive (HP:0003678)2.08547096
133Submucous cleft hard palate (HP:0000176)2.08054663
134Muscle fibrillation (HP:0010546)2.06133004
135Fetal akinesia sequence (HP:0001989)2.05015153
136Nausea (HP:0002018)2.03901744
137Apathy (HP:0000741)2.03230597
138Cerebral inclusion bodies (HP:0100314)2.02375409
139Spinal muscular atrophy (HP:0007269)2.01698414
140Abnormal autonomic nervous system physiology (HP:0012332)2.01448478
141Oral leukoplakia (HP:0002745)2.01166526
142Congenital primary aphakia (HP:0007707)2.00939302
143Poor suck (HP:0002033)2.00339116
144Focal seizures (HP:0007359)1.99839635
145Nephrogenic diabetes insipidus (HP:0009806)1.99697356
146Increased CSF lactate (HP:0002490)1.99245569
147Congenital ichthyosiform erythroderma (HP:0007431)1.99190537
148Short tibia (HP:0005736)1.98946274
149Bone marrow hypocellularity (HP:0005528)1.98301549
150Long foot (HP:0001833)1.98070318
151Increased mean platelet volume (HP:0011877)1.95720795
152Short nail (HP:0001799)1.95189356
153Meckel diverticulum (HP:0002245)1.95179222
154Increased intramyocellular lipid droplets (HP:0012240)1.95031211
155Hemiparesis (HP:0001269)1.94738591
156Mitochondrial inheritance (HP:0001427)1.93711359
157Azoospermia (HP:0000027)1.93244971
158Dysostosis multiplex (HP:0000943)1.92830109
159Brittle hair (HP:0002299)1.92224724
160Aplasia/Hypoplasia of the earlobes (HP:0009906)1.92100374
161Stomach cancer (HP:0012126)1.90664461
162Neonatal respiratory distress (HP:0002643)1.90625666
163Spastic paraparesis (HP:0002313)1.90411169
164Impaired vibration sensation in the lower limbs (HP:0002166)1.89860333
165Aplasia of the musculature (HP:0100854)1.89050262
166Premature graying of hair (HP:0002216)1.88873106
167Gingival bleeding (HP:0000225)1.88074447
168Increased serum ferritin (HP:0003281)1.87780398
169Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.87693735
170Absent epiphyses (HP:0010577)1.87693735
171Lethargy (HP:0001254)1.87413356
172Generalized tonic-clonic seizures (HP:0002069)1.87072272
173Trismus (HP:0000211)1.86959024
174Urinary urgency (HP:0000012)1.85764095
175Abnormal neuron morphology (HP:0012757)1.85508776
176Abnormality of the motor neurons (HP:0002450)1.85508776
177Agitation (HP:0000713)1.85373782
178Emotional lability (HP:0000712)1.85198774
179Vacuolated lymphocytes (HP:0001922)1.82989790
180Hammertoe (HP:0001765)1.82921040
181Generalized aminoaciduria (HP:0002909)1.81921023
182Intention tremor (HP:0002080)1.81414343
183Rhabdomyolysis (HP:0003201)1.81192709
184Abnormality of the musculature of the pelvis (HP:0001469)1.80590251
185Abnormality of the hip-girdle musculature (HP:0001445)1.80590251
186Abnormal platelet volume (HP:0011876)1.79977093
187Metaphyseal dysplasia (HP:0100255)1.79427843
188Bradykinesia (HP:0002067)1.75692458
189Epistaxis (HP:0000421)1.73031161
190Specific learning disability (HP:0001328)1.71121634
191Episodic fever (HP:0001954)1.71102459
192Anxiety (HP:0000739)1.69697094

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.94787471
2WEE14.34431050
3TSSK63.98097613
4PLK43.97787023
5STK163.80625173
6AKT33.49357520
7IRAK33.24801869
8TESK13.10358078
9EIF2AK12.92781767
10EPHA22.67775327
11LIMK12.67059862
12ZAK2.66178798
13PNCK2.64193878
14SRPK12.47643604
15TRIM281.98675831
16SIK31.98408181
17ARAF1.97916912
18PLK31.97434365
19PAK61.94921047
20EIF2AK31.83387529
21MAP2K71.80672847
22MAP4K21.76752511
23BRSK21.74825146
24PINK11.69601594
25MAP3K51.66519582
26PIM21.62973617
27NME11.60940295
28MARK11.59533149
29NEK11.58407126
30NME21.57689676
31PHKG11.57098237
32PHKG21.57098237
33MAP3K41.53500222
34DAPK21.52689279
35CCNB11.51859233
36TTK1.50422432
37PDK41.46077029
38PDK31.46077029
39EPHA31.43889059
40DYRK1B1.43107108
41PLK11.39662924
42MAP3K111.36251784
43PDK21.36216639
44MINK11.35733924
45BRAF1.34811144
46BRSK11.29047082
47MKNK21.23869770
48PAK31.22752066
49DYRK31.19658727
50ACVR1B1.18191450
51GRK71.15467370
52NEK21.11511467
53ERBB31.11411726
54TAOK21.09694960
55STK38L1.09388393
56CDK141.08223838
57IRAK21.08167397
58IRAK41.06994812
59RIPK41.05674844
60VRK11.04094185
61UHMK11.03082287
62MKNK11.02334119
63DYRK21.00717474
64PTK2B0.97908120
65MAP2K40.97162923
66EPHB10.95550347
67MOS0.94882180
68MAPK130.93263774
69TESK20.92813611
70AURKA0.92020709
71PRKCI0.90943339
72CDK50.89812642
73LMTK20.89608299
74KSR10.89129505
75NTRK10.88110358
76EPHA40.87405931
77NTRK30.85020957
78CASK0.83569147
79TAOK30.83405050
80DYRK1A0.82865033
81STK240.82231730
82CDK180.79777895
83CAMK2A0.79358629
84KSR20.78855093
85CHEK20.77496821
86TBK10.76985328
87AURKB0.75472826
88SIK20.73007689
89EIF2AK20.71967532
90CDK150.71711349
91IRAK10.70353252
92CDK11A0.68752839
93DAPK30.67532091
94MAP3K90.62056801
95ABL20.61934590
96TAOK10.61643631
97OBSCN0.59827303
98PKN10.59357818
99LATS20.58360504
100NTRK20.57454017
101MAPK120.56968906
102PRKCG0.55041592
103BMX0.51144138
104CSNK2A10.51056229
105MATK0.51006830
106PRKD10.50682486
107PAK10.48718260
108CAMKK20.48093623
109BCR0.47433563
110CSNK1G30.46918013
111JAK20.46120205
112KDR0.46066862
113NEK60.44520015
114CDK190.43868981
115FER0.43819957
116MAP3K120.42963434
117CAMK2G0.42789735
118PLK20.42732092
119BCKDK0.41507533
120NUAK10.41429383
121MAP3K60.41419605
122FES0.38893250
123CSNK2A20.38408984
124MAP3K30.37673585
125EPHB20.37292795
126SYK0.37260845
127PIK3CG0.36776448
128ILK0.36203179
129MARK20.34959162
130CDK30.34743613
131STK380.34117094
132CHEK10.32954127
133RPS6KA50.32930385
134GRK60.32552200
135ADRBK10.32340208
136TLK10.31897680
137MST40.29919685
138CAMK2B0.29392908
139ATR0.29094667
140STK30.28875592
141CSNK1E0.28661301
142CSNK1A10.28316715
143WNK30.28056579
144PIM10.27983563
145ALK0.26402366
146CSNK1G10.24065834
147CDK20.23949308
148GRK10.23581322
149GRK50.22890769
150OXSR10.22017811
151PRKCE0.20707945
152PAK40.20169353
153MAP3K80.19610490
154CDK10.18416705
155CDK70.17863414
156BMPR20.17764683
157CAMK2D0.17549299
158CSNK1G20.17280249
159CSNK1A1L0.16239074
160RAF10.14932830
161RPS6KA40.13193549
162MYLK0.12034848
163IKBKB0.11389758
164MAPK40.11141755
165RPS6KB20.09775853
166ADRBK20.09418791

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.94736396
2Vitamin B6 metabolism_Homo sapiens_hsa007505.37096012
3RNA polymerase_Homo sapiens_hsa030205.34060693
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.06009866
5Regulation of autophagy_Homo sapiens_hsa041403.19617872
6Pyrimidine metabolism_Homo sapiens_hsa002402.78226662
7RNA transport_Homo sapiens_hsa030132.77780649
8Ribosome_Homo sapiens_hsa030102.51543483
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.49316689
10GABAergic synapse_Homo sapiens_hsa047272.35353124
11Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.31887651
12Spliceosome_Homo sapiens_hsa030402.25170481
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.23076985
14Basal transcription factors_Homo sapiens_hsa030222.11961436
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.93854264
16DNA replication_Homo sapiens_hsa030301.91313821
17Purine metabolism_Homo sapiens_hsa002301.89870859
18Pentose phosphate pathway_Homo sapiens_hsa000301.79168490
19Nucleotide excision repair_Homo sapiens_hsa034201.75070389
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.72685970
21Folate biosynthesis_Homo sapiens_hsa007901.68180445
22Cell cycle_Homo sapiens_hsa041101.68030826
23Morphine addiction_Homo sapiens_hsa050321.65309966
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.60263364
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59812640
26Mismatch repair_Homo sapiens_hsa034301.58434696
27Homologous recombination_Homo sapiens_hsa034401.54757514
28Oxidative phosphorylation_Homo sapiens_hsa001901.54197245
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.50914620
30Salmonella infection_Homo sapiens_hsa051321.48457623
31Dopaminergic synapse_Homo sapiens_hsa047281.48349872
32Collecting duct acid secretion_Homo sapiens_hsa049661.48246656
33Epstein-Barr virus infection_Homo sapiens_hsa051691.46425270
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.45415756
35Circadian entrainment_Homo sapiens_hsa047131.44759024
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.42894765
37Fanconi anemia pathway_Homo sapiens_hsa034601.35841307
38Fructose and mannose metabolism_Homo sapiens_hsa000511.35361489
39Amphetamine addiction_Homo sapiens_hsa050311.34317174
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.31307598
41Base excision repair_Homo sapiens_hsa034101.29945866
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28971936
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28947325
44Glycerophospholipid metabolism_Homo sapiens_hsa005641.26091505
45Huntingtons disease_Homo sapiens_hsa050161.24107964
46Glutamatergic synapse_Homo sapiens_hsa047241.22943841
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22131411
48Parkinsons disease_Homo sapiens_hsa050121.21031260
49Cocaine addiction_Homo sapiens_hsa050301.11325479
50p53 signaling pathway_Homo sapiens_hsa041151.09236883
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04242824
52Vitamin digestion and absorption_Homo sapiens_hsa049771.01983832
53Drug metabolism - other enzymes_Homo sapiens_hsa009831.01277823
54Oocyte meiosis_Homo sapiens_hsa041140.97948098
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95586226
56RNA degradation_Homo sapiens_hsa030180.94611631
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92985424
58Protein export_Homo sapiens_hsa030600.91062213
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91058665
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90181785
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88929681
62Long-term potentiation_Homo sapiens_hsa047200.86134388
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86130414
64Insulin secretion_Homo sapiens_hsa049110.85236223
65Gap junction_Homo sapiens_hsa045400.82244045
66Alcoholism_Homo sapiens_hsa050340.82024080
67Long-term depression_Homo sapiens_hsa047300.80262927
68Tuberculosis_Homo sapiens_hsa051520.79079021
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76084251
70Gastric acid secretion_Homo sapiens_hsa049710.75674515
71Sulfur metabolism_Homo sapiens_hsa009200.75670399
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74341430
73Oxytocin signaling pathway_Homo sapiens_hsa049210.72921230
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72585639
75Cholinergic synapse_Homo sapiens_hsa047250.72514060
76Glutathione metabolism_Homo sapiens_hsa004800.71289630
77Metabolic pathways_Homo sapiens_hsa011000.70404696
78Salivary secretion_Homo sapiens_hsa049700.68469751
79Serotonergic synapse_Homo sapiens_hsa047260.66530317
80Pertussis_Homo sapiens_hsa051330.64435081
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64149796
82Synaptic vesicle cycle_Homo sapiens_hsa047210.63753810
83Dilated cardiomyopathy_Homo sapiens_hsa054140.63083578
84Olfactory transduction_Homo sapiens_hsa047400.62961785
85Carbon metabolism_Homo sapiens_hsa012000.62749396
86Rheumatoid arthritis_Homo sapiens_hsa053230.62601474
87Ras signaling pathway_Homo sapiens_hsa040140.60736018
88Circadian rhythm_Homo sapiens_hsa047100.59613126
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59397095
90Biosynthesis of amino acids_Homo sapiens_hsa012300.59340421
91mRNA surveillance pathway_Homo sapiens_hsa030150.58321210
92Renin secretion_Homo sapiens_hsa049240.57769666
93Arachidonic acid metabolism_Homo sapiens_hsa005900.57486348
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.54744131
95Calcium signaling pathway_Homo sapiens_hsa040200.53760606
96Alzheimers disease_Homo sapiens_hsa050100.52959873
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52862230
98AMPK signaling pathway_Homo sapiens_hsa041520.51543032
99Sphingolipid metabolism_Homo sapiens_hsa006000.51304838
100Lysosome_Homo sapiens_hsa041420.50006570
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49952368
102Platelet activation_Homo sapiens_hsa046110.49911429
103Vibrio cholerae infection_Homo sapiens_hsa051100.49906723
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49697712
105Prion diseases_Homo sapiens_hsa050200.48918249
106GnRH signaling pathway_Homo sapiens_hsa049120.47019828
107Chemokine signaling pathway_Homo sapiens_hsa040620.45128469
108Taste transduction_Homo sapiens_hsa047420.44328784
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44031703
110Sulfur relay system_Homo sapiens_hsa041220.43746553
111cAMP signaling pathway_Homo sapiens_hsa040240.41527416
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41488502
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41292085
114Axon guidance_Homo sapiens_hsa043600.39944673
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39729166
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.39271770
117Arginine and proline metabolism_Homo sapiens_hsa003300.37605175
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37453461
119Malaria_Homo sapiens_hsa051440.35370656
120Fatty acid elongation_Homo sapiens_hsa000620.34800471
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.34605020
122MAPK signaling pathway_Homo sapiens_hsa040100.34051157
123cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33497026
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32869829
125Osteoclast differentiation_Homo sapiens_hsa043800.32331215
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31552739
127One carbon pool by folate_Homo sapiens_hsa006700.29675679
128Renin-angiotensin system_Homo sapiens_hsa046140.28769818
129Antigen processing and presentation_Homo sapiens_hsa046120.28459251
130Rap1 signaling pathway_Homo sapiens_hsa040150.26583197
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22743297
132Non-homologous end-joining_Homo sapiens_hsa034500.22066322
133Galactose metabolism_Homo sapiens_hsa000520.21476858
134Phototransduction_Homo sapiens_hsa047440.21186899
135Mineral absorption_Homo sapiens_hsa049780.19398000
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.18917563
137Phagosome_Homo sapiens_hsa041450.18611595
138Linoleic acid metabolism_Homo sapiens_hsa005910.17417134
139Steroid biosynthesis_Homo sapiens_hsa001000.16923465
140Glycerolipid metabolism_Homo sapiens_hsa005610.15352297
141beta-Alanine metabolism_Homo sapiens_hsa004100.13634924
142FoxO signaling pathway_Homo sapiens_hsa040680.13147726
143Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.10714439
144NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10525292
145Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.10076528
146Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07652917
147Ether lipid metabolism_Homo sapiens_hsa005650.07487880
148Butanoate metabolism_Homo sapiens_hsa006500.06897128
149Viral carcinogenesis_Homo sapiens_hsa052030.06750350
150Cardiac muscle contraction_Homo sapiens_hsa042600.04160111
151Intestinal immune network for IgA production_Homo sapiens_hsa046720.01624378
152Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.00553147
153Legionellosis_Homo sapiens_hsa051340.00110188
154Nicotine addiction_Homo sapiens_hsa05033-0.0254264
155Inositol phosphate metabolism_Homo sapiens_hsa00562-0.0219441
156Shigellosis_Homo sapiens_hsa05131-0.0208995
157Endocytosis_Homo sapiens_hsa04144-0.0171027
158Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250-0.0044307
159alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0018588

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