MAP1LC3B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.85047026
2platelet dense granule organization (GO:0060155)4.55948929
3iron-sulfur cluster assembly (GO:0016226)4.40113199
4metallo-sulfur cluster assembly (GO:0031163)4.40113199
5protein-cofactor linkage (GO:0018065)4.32621975
6positive regulation of mitochondrial fission (GO:0090141)4.11697514
7protein complex biogenesis (GO:0070271)4.05250297
8sequestering of actin monomers (GO:0042989)4.01371708
9Arp2/3 complex-mediated actin nucleation (GO:0034314)3.90796527
10mitochondrial respiratory chain complex I assembly (GO:0032981)3.88453217
11NADH dehydrogenase complex assembly (GO:0010257)3.88453217
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.88453217
13proteasome assembly (GO:0043248)3.86818885
14tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.82025138
15RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.82025138
16mannosylation (GO:0097502)3.77125394
17GPI anchor metabolic process (GO:0006505)3.74231152
18base-excision repair, AP site formation (GO:0006285)3.73484181
19protein neddylation (GO:0045116)3.72749275
20cytidine deamination (GO:0009972)3.72124134
21cytidine metabolic process (GO:0046087)3.72124134
22cytidine catabolic process (GO:0006216)3.72124134
23mitochondrial respiratory chain complex assembly (GO:0033108)3.66883121
24GPI anchor biosynthetic process (GO:0006506)3.62804813
25ATP synthesis coupled proton transport (GO:0015986)3.59482568
26energy coupled proton transport, down electrochemical gradient (GO:0015985)3.59482568
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.58685502
28preassembly of GPI anchor in ER membrane (GO:0016254)3.57128526
29deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.50194899
30actin nucleation (GO:0045010)3.44379066
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.43139703
32respiratory electron transport chain (GO:0022904)3.28214153
33electron transport chain (GO:0022900)3.25026023
34L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.24789158
35nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22474902
36pyrimidine ribonucleoside catabolic process (GO:0046133)3.19051593
37respiratory chain complex IV assembly (GO:0008535)3.17283551
38regulation of cellular amino acid metabolic process (GO:0006521)3.08438148
39pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.06579672
40protein deneddylation (GO:0000338)3.05083223
41C-terminal protein lipidation (GO:0006501)3.04800283
42chaperone-mediated protein transport (GO:0072321)3.00340295
43regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.00032172
44purine deoxyribonucleotide catabolic process (GO:0009155)2.98718131
45exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.97775663
46cullin deneddylation (GO:0010388)2.94700825
47regulation of mitochondrial fission (GO:0090140)2.94121149
48deoxyribonucleotide catabolic process (GO:0009264)2.92621258
49C-terminal protein amino acid modification (GO:0018410)2.85544480
50DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.83908808
51ATP hydrolysis coupled proton transport (GO:0015991)2.83607267
52energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.83607267
53L-methionine salvage (GO:0071267)2.78103515
54L-methionine biosynthetic process (GO:0071265)2.78103515
55amino acid salvage (GO:0043102)2.78103515
56hydrogen ion transmembrane transport (GO:1902600)2.76414140
57deoxyribose phosphate catabolic process (GO:0046386)2.75685631
58proton transport (GO:0015992)2.75102382
59negative regulation of telomere maintenance (GO:0032205)2.73465605
60cytochrome complex assembly (GO:0017004)2.72300104
61hydrogen transport (GO:0006818)2.71676777
62signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.69801687
63signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.69801687
64signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.69801687
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.68351161
66signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.68351161
67negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.67398020
68anterograde synaptic vesicle transport (GO:0048490)2.66671142
69adenosine metabolic process (GO:0046085)2.63265160
70glycolipid biosynthetic process (GO:0009247)2.62082785
71signal transduction involved in cell cycle checkpoint (GO:0072395)2.58042063
72ubiquinone biosynthetic process (GO:0006744)2.57984834
73piRNA metabolic process (GO:0034587)2.56930858
74positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.56425553
75pyrimidine nucleotide catabolic process (GO:0006244)2.54892900
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.54033771
77deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.53267207
78signal transduction involved in DNA integrity checkpoint (GO:0072401)2.52375320
79signal transduction involved in DNA damage checkpoint (GO:0072422)2.52375320
80purine deoxyribonucleotide metabolic process (GO:0009151)2.50754607
81establishment of protein localization to mitochondrial membrane (GO:0090151)2.50522791
82negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.49431131
83chaperone mediated protein folding requiring cofactor (GO:0051085)2.49206262
84negative regulation of mast cell activation (GO:0033004)2.48733255
85response to pheromone (GO:0019236)2.46880016
86pyrimidine-containing compound catabolic process (GO:0072529)2.46010262
87transcription elongation from RNA polymerase III promoter (GO:0006385)2.43612399
88termination of RNA polymerase III transcription (GO:0006386)2.43612399
892-deoxyribonucleotide metabolic process (GO:0009394)2.43351385
90positive regulation of interleukin-8 secretion (GO:2000484)2.42659102
91peptidyl-histidine modification (GO:0018202)2.40019016
92antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.39705066
93ubiquinone metabolic process (GO:0006743)2.39102689
94pyrimidine nucleobase catabolic process (GO:0006208)2.39084237
95peroxisome fission (GO:0016559)2.38806949
96negative regulation of membrane potential (GO:0045837)2.37684924
97tRNA processing (GO:0008033)2.37460598
98protein localization to cilium (GO:0061512)2.37338097
99purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.37221968
100positive regulation of prostaglandin secretion (GO:0032308)2.36459011

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.17684744
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.94081183
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.78185531
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.64558262
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.21049832
6ZNF274_21170338_ChIP-Seq_K562_Hela3.08335330
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.06563610
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.03440669
9VDR_23849224_ChIP-Seq_CD4+_Human2.92561858
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.70732636
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.58665612
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.52548814
13IGF1R_20145208_ChIP-Seq_DFB_Human2.52378373
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.46366761
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.18848018
16FOXP3_21729870_ChIP-Seq_TREG_Human2.16995956
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.16743223
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.13859664
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.13106671
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08770811
21ELK1_19687146_ChIP-ChIP_HELA_Human2.07764726
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05884996
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.95105944
24VDR_22108803_ChIP-Seq_LS180_Human1.84151499
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83876092
26IRF1_19129219_ChIP-ChIP_H3396_Human1.82668964
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80142803
28GABP_19822575_ChIP-Seq_HepG2_Human1.73031730
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.66777398
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65445643
31TP53_22573176_ChIP-Seq_HFKS_Human1.64469068
32MYC_18940864_ChIP-ChIP_HL60_Human1.61326188
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.56832868
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.55101494
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53202330
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52281140
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51633757
38TAF15_26573619_Chip-Seq_HEK293_Human1.51251201
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49482842
40PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.44508115
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44038164
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42173272
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42136109
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40819977
45DCP1A_22483619_ChIP-Seq_HELA_Human1.35720352
46GATA3_26560356_Chip-Seq_TH2_Human1.34932924
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.34159972
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32069602
49CIITA_25753668_ChIP-Seq_RAJI_Human1.27935790
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27559724
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24223311
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.23874860
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23874860
54AR_20517297_ChIP-Seq_VCAP_Human1.18236720
55PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17800454
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15506266
57IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14020508
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13004971
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12888705
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11585216
61NCOR_22424771_ChIP-Seq_293T_Human1.11056390
62GBX2_23144817_ChIP-Seq_PC3_Human1.10957361
63* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10808797
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10421982
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.09024290
66EWS_26573619_Chip-Seq_HEK293_Human1.08552473
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07542634
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04990435
69* P300_19829295_ChIP-Seq_ESCs_Human1.04046042
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03774576
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03624352
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03504430
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02858296
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.01257376
75RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00980794
76EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00696196
77NANOG_20526341_ChIP-Seq_ESCs_Human0.99364726
78NANOG_19829295_ChIP-Seq_ESCs_Human0.98898297
79SOX2_19829295_ChIP-Seq_ESCs_Human0.98898297
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98797940
81AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97760497
82HTT_18923047_ChIP-ChIP_STHdh_Human0.97198208
83TAF2_19829295_ChIP-Seq_ESCs_Human0.96751502
84CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96345729
85FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95736042
86MYC_18358816_ChIP-ChIP_MESCs_Mouse0.95300665
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95132139
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94878703
89MYC_19829295_ChIP-Seq_ESCs_Human0.94247740
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94035930
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94021200
92GATA3_27048872_Chip-Seq_THYMUS_Human0.93954569
93* MYB_26560356_Chip-Seq_TH2_Human0.93276106
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92182114
95CBP_20019798_ChIP-Seq_JUKART_Human0.91740030
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91740030
97TTF2_22483619_ChIP-Seq_HELA_Human0.91663298
98BCL6_27268052_Chip-Seq_Bcells_Human0.91245409
99* SPI1_23547873_ChIP-Seq_NB4_Human0.90599455
100EZH2_22144423_ChIP-Seq_EOC_Human0.89567935

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.23896545
2MP0004147_increased_porphyrin_level3.12540985
3MP0002102_abnormal_ear_morphology3.00333319
4MP0001835_abnormal_antigen_presentation2.60364800
5MP0006072_abnormal_retinal_apoptosis2.35858584
6MP0001529_abnormal_vocalization2.31164396
7MP0005645_abnormal_hypothalamus_physiol2.28441617
8MP0009785_altered_susceptibility_to2.11279442
9MP0008877_abnormal_DNA_methylation2.10798589
10MP0005084_abnormal_gallbladder_morpholo2.01990849
11MP0008995_early_reproductive_senescence1.97550711
12MP0001905_abnormal_dopamine_level1.95212967
13MP0003724_increased_susceptibility_to1.92305492
14MP0002653_abnormal_ependyma_morphology1.92146125
15MP0006276_abnormal_autonomic_nervous1.81074163
16MP0001984_abnormal_olfaction1.78501497
17MP0000372_irregular_coat_pigmentation1.77754262
18MP0009046_muscle_twitch1.73145594
19MP0002837_dystrophic_cardiac_calcinosis1.72553312
20MP0006036_abnormal_mitochondrial_physio1.71145489
21MP0005253_abnormal_eye_physiology1.70080219
22MP0003806_abnormal_nucleotide_metabolis1.70068991
23MP0009764_decreased_sensitivity_to1.69875409
24MP0002148_abnormal_hypersensitivity_rea1.69530097
25MP0001968_abnormal_touch/_nociception1.66776511
26MP0003011_delayed_dark_adaptation1.64305369
27MP0005551_abnormal_eye_electrophysiolog1.61452401
28MP0003786_premature_aging1.59805166
29MP0003880_abnormal_central_pattern1.57336784
30MP0001986_abnormal_taste_sensitivity1.56981196
31MP0004142_abnormal_muscle_tone1.55919282
32MP0006035_abnormal_mitochondrial_morpho1.51818485
33MP0001800_abnormal_humoral_immune1.51125736
34MP0002736_abnormal_nociception_after1.48766419
35MP0005075_abnormal_melanosome_morpholog1.46218279
36MP0005000_abnormal_immune_tolerance1.44812604
37MP0008872_abnormal_physiological_respon1.44436431
38MP0008058_abnormal_DNA_repair1.40941194
39MP0002723_abnormal_immune_serum1.40838853
40MP0003646_muscle_fatigue1.38460090
41MP0003186_abnormal_redox_activity1.33953094
42MP0002822_catalepsy1.33029303
43MP0008789_abnormal_olfactory_epithelium1.32453082
44MP0005646_abnormal_pituitary_gland1.29857209
45MP0009745_abnormal_behavioral_response1.29729050
46MP0002452_abnormal_antigen_presenting1.27310373
47MP0001819_abnormal_immune_cell1.24556710
48MP0005394_taste/olfaction_phenotype1.24310902
49MP0005499_abnormal_olfactory_system1.24310902
50MP0001764_abnormal_homeostasis1.23649801
51MP0002420_abnormal_adaptive_immunity1.23644069
52MP0002277_abnormal_respiratory_mucosa1.23156260
53MP0002876_abnormal_thyroid_physiology1.21364862
54MP0005367_renal/urinary_system_phenotyp1.19312446
55MP0000516_abnormal_urinary_system1.19312446
56MP0002272_abnormal_nervous_system1.17103432
57MP0003195_calcinosis1.14534878
58MP0005025_abnormal_response_to1.14481499
59MP0001790_abnormal_immune_system1.13350881
60MP0005387_immune_system_phenotype1.13350881
61MP0008875_abnormal_xenobiotic_pharmacok1.13049292
62MP0000685_abnormal_immune_system1.09201770
63MP0003122_maternal_imprinting1.08709254
64MP0003787_abnormal_imprinting1.00411497
65MP0001501_abnormal_sleep_pattern0.96784111
66MP0002234_abnormal_pharynx_morphology0.96663369
67MP0001919_abnormal_reproductive_system0.95429568
68MP0000465_gastrointestinal_hemorrhage0.94740037
69MP0000716_abnormal_immune_system0.93467755
70MP0005410_abnormal_fertilization0.92618962
71MP0003718_maternal_effect0.89160658
72MP0000631_abnormal_neuroendocrine_gland0.88573488
73MP0001970_abnormal_pain_threshold0.86691945
74MP0002163_abnormal_gland_morphology0.85164875
75MP0005379_endocrine/exocrine_gland_phen0.85144483
76MP0001845_abnormal_inflammatory_respons0.84893576
77MP0002572_abnormal_emotion/affect_behav0.84611793
78MP0002733_abnormal_thermal_nociception0.83837148
79MP0000689_abnormal_spleen_morphology0.83830814
80MP0009765_abnormal_xenobiotic_induced0.83557235
81MP0005386_behavior/neurological_phenoty0.83005992
82MP0004924_abnormal_behavior0.83005992
83MP0009763_increased_sensitivity_to0.82756406
84MP0005389_reproductive_system_phenotype0.82306301
85MP0002751_abnormal_autonomic_nervous0.82306130
86MP0002095_abnormal_skin_pigmentation0.81409963
87MP0005332_abnormal_amino_acid0.80632783
88MP0003121_genomic_imprinting0.80450712
89MP0006082_CNS_inflammation0.80108517
90MP0002638_abnormal_pupillary_reflex0.79994734
91MP0002419_abnormal_innate_immunity0.79891017
92MP0001188_hyperpigmentation0.79497794
93MP0001542_abnormal_bone_strength0.79311142
94MP0003763_abnormal_thymus_physiology0.78836311
95MP0002398_abnormal_bone_marrow0.77985275
96MP0003866_abnormal_defecation0.77510796
97MP0001502_abnormal_circadian_rhythm0.75876130
98MP0002332_abnormal_exercise_endurance0.73954415
99MP0005636_abnormal_mineral_homeostasis0.73811691
100MP0002735_abnormal_chemical_nociception0.73739159

Predicted human phenotypes

RankGene SetZ-score
1Mitochondrial inheritance (HP:0001427)4.05225335
2Acute necrotizing encephalopathy (HP:0006965)4.00554910
3Abnormal mitochondria in muscle tissue (HP:0008316)3.94242375
4Hepatocellular necrosis (HP:0001404)3.93997035
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.91728048
6Decreased activity of mitochondrial respiratory chain (HP:0008972)3.91728048
7Increased CSF lactate (HP:0002490)3.75651431
8Hepatic necrosis (HP:0002605)3.74015042
93-Methylglutaconic aciduria (HP:0003535)3.71188905
10Acute encephalopathy (HP:0006846)3.50367126
11Progressive macrocephaly (HP:0004481)3.37951645
12Increased hepatocellular lipid droplets (HP:0006565)3.20974194
13Increased intramyocellular lipid droplets (HP:0012240)3.20048168
14Lipid accumulation in hepatocytes (HP:0006561)3.14158770
15Pancreatic cysts (HP:0001737)3.06123366
16Renal Fanconi syndrome (HP:0001994)2.97125200
17Increased serum lactate (HP:0002151)2.85022873
18Lactic acidosis (HP:0003128)2.79569068
19Increased muscle lipid content (HP:0009058)2.79100597
20Medial flaring of the eyebrow (HP:0010747)2.73131545
21IgG deficiency (HP:0004315)2.66787017
22Type II lissencephaly (HP:0007260)2.66225475
23Abolished electroretinogram (ERG) (HP:0000550)2.64852448
24Retinal dysplasia (HP:0007973)2.59012969
25Renal cortical cysts (HP:0000803)2.56619150
26Type I transferrin isoform profile (HP:0003642)2.56496034
27Pancreatic fibrosis (HP:0100732)2.55536565
28True hermaphroditism (HP:0010459)2.51588774
29Abnormal protein glycosylation (HP:0012346)2.50284555
30Abnormal glycosylation (HP:0012345)2.50284555
31Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.50284555
32Abnormal protein N-linked glycosylation (HP:0012347)2.50284555
33Generalized aminoaciduria (HP:0002909)2.46788771
34Cerebral edema (HP:0002181)2.45640519
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.43368842
36Abnormality of midbrain morphology (HP:0002418)2.41099277
37Molar tooth sign on MRI (HP:0002419)2.41099277
38Hyperglycinemia (HP:0002154)2.40927923
39Methylmalonic acidemia (HP:0002912)2.36157584
40Congenital stationary night blindness (HP:0007642)2.36054688
41Optic disc pallor (HP:0000543)2.35418518
42Aplasia/hypoplasia of the uterus (HP:0008684)2.34965093
43Severe combined immunodeficiency (HP:0004430)2.34394839
44Exertional dyspnea (HP:0002875)2.34237450
45Elevated erythrocyte sedimentation rate (HP:0003565)2.32850779
46Decreased electroretinogram (ERG) amplitude (HP:0000654)2.32087582
47Lissencephaly (HP:0001339)2.28061232
48Stomatitis (HP:0010280)2.27888726
49Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.26899785
50Methylmalonic aciduria (HP:0012120)2.26321603
51Congenital primary aphakia (HP:0007707)2.21051922
52Gait imbalance (HP:0002141)2.20561051
53Aplastic anemia (HP:0001915)2.19991562
54Delayed CNS myelination (HP:0002188)2.19795680
55Atrophy/Degeneration involving motor neurons (HP:0007373)2.19021175
56Amyotrophic lateral sclerosis (HP:0007354)2.14865883
57Respiratory failure (HP:0002878)2.13263778
58Nephrogenic diabetes insipidus (HP:0009806)2.12454790
59Emotional lability (HP:0000712)2.10140052
60Progressive microcephaly (HP:0000253)2.08771442
61Abnormality of alanine metabolism (HP:0010916)2.08499275
62Hyperalaninemia (HP:0003348)2.08499275
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08499275
64Exercise intolerance (HP:0003546)2.06015896
65Polyphagia (HP:0002591)2.04993992
66Lethargy (HP:0001254)2.04665925
67CNS demyelination (HP:0007305)2.03816269
68Increased IgM level (HP:0003496)2.01168904
69Abnormality of urine glucose concentration (HP:0011016)2.00731779
70Glycosuria (HP:0003076)2.00731779
71Abnormality of dicarboxylic acid metabolism (HP:0010995)1.97957137
72Dicarboxylic aciduria (HP:0003215)1.97957137
73Short tibia (HP:0005736)1.97929455
74Hypothermia (HP:0002045)1.93500414
75Thyroiditis (HP:0100646)1.91686088
76Attenuation of retinal blood vessels (HP:0007843)1.90880352
77Abnormality of the renal cortex (HP:0011035)1.90789286
78Abnormality of the anterior horn cell (HP:0006802)1.88361549
79Degeneration of anterior horn cells (HP:0002398)1.88361549
80Abnormality of the heme biosynthetic pathway (HP:0010472)1.88041822
81Sclerocornea (HP:0000647)1.86447241
82Abnormality of renal resorption (HP:0011038)1.84783610
83Hypoproteinemia (HP:0003075)1.83652451
84Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82983037
85Abnormality of the prostate (HP:0008775)1.81912552
86Abnormality of eosinophils (HP:0001879)1.81409949
87Aplasia/Hypoplasia of the tibia (HP:0005772)1.80457762
88Failure to thrive in infancy (HP:0001531)1.79480436
89Inability to walk (HP:0002540)1.76753251
90Pachygyria (HP:0001302)1.76689305
91Progressive inability to walk (HP:0002505)1.74448903
92Abnormal rod and cone electroretinograms (HP:0008323)1.73410496
93Cerebral palsy (HP:0100021)1.72980634
94Pendular nystagmus (HP:0012043)1.70487053
95Increased serum pyruvate (HP:0003542)1.69976683
96Ketoacidosis (HP:0001993)1.69917858
97Nephronophthisis (HP:0000090)1.68742585
98Acute hepatic failure (HP:0006554)1.68432964
99Ketosis (HP:0001946)1.68331810
100Hypoplasia of the uterus (HP:0000013)1.66425744

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.41054361
2MAP4K24.25657751
3BCKDK3.46378914
4TAOK32.51380497
5TRIM282.43654205
6TXK2.39660443
7BCR2.20790290
8KDR2.14360048
9ZAK2.08440212
10CDK192.01251638
11CSNK1G31.98474735
12FRK1.95811000
13TLK11.95719672
14LIMK11.81182762
15MAP2K71.79844306
16PINK11.71145754
17TESK11.70744816
18WNK31.70609392
19CSNK1G21.69123829
20CSNK1A1L1.68669223
21ADRBK21.68548891
22GRK11.59327502
23NUAK11.52243331
24VRK21.48304538
25CSNK1G11.46997436
26ERBB31.41685266
27VRK11.41090694
28MAP3K41.38181668
29MAPK131.33613491
30MAP3K121.31718683
31SRPK11.31525480
32PIM21.30693757
33INSRR1.24719673
34RPS6KA51.16365310
35DYRK21.15419568
36MAP4K10.96870453
37IKBKB0.96557192
38OXSR10.94649658
39GRK60.92738388
40EIF2AK30.90723549
41IKBKE0.86741827
42SIK30.85934558
43STK160.84351662
44EPHA30.84051346
45RPS6KA40.83890160
46SYK0.81133544
47DAPK10.79008564
48CCNB10.78895080
49TEC0.78780987
50DYRK30.77172346
51TIE10.76025002
52MAP3K50.75304953
53BMPR20.74978025
54TBK10.74706713
55ITK0.74355234
56LYN0.72982505
57FES0.72629965
58GRK70.71984742
59MINK10.70401528
60KIT0.70126498
61MARK10.70035394
62PRKCE0.69283808
63PLK20.68518391
64MST40.68329789
65FLT30.66324895
66PRKCQ0.63263714
67DAPK20.62563265
68BMPR1B0.61205096
69SCYL20.60645645
70MAPKAPK30.60572358
71CSF1R0.60106841
72PAK30.57115117
73ADRBK10.56665844
74WNK40.55162883
75MAP3K110.53712529
76PHKG20.53627560
77PHKG10.53627560
78ARAF0.52186905
79DAPK30.49317522
80BUB10.48664515
81LCK0.48662967
82MATK0.48569983
83PTK2B0.47730680
84CSNK2A10.43238056
85PLK40.42015555
86AURKA0.41252771
87MYLK0.41246089
88CSNK1A10.40777822
89PRKACA0.40038146
90GRK50.39874967
91BTK0.38480931
92MUSK0.36885028
93PIK3CG0.35821567
94ABL10.35784197
95JAK30.35069311
96CAMK2A0.34810807
97DYRK1B0.34534498
98PIM10.33745795
99ABL20.33605898
100IGF1R0.31781030

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.87596457
2Proteasome_Homo sapiens_hsa030503.47794111
3Parkinsons disease_Homo sapiens_hsa050123.18153378
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.93410266
5Protein export_Homo sapiens_hsa030602.82352118
6Asthma_Homo sapiens_hsa053102.62126979
7Graft-versus-host disease_Homo sapiens_hsa053322.48350008
8Allograft rejection_Homo sapiens_hsa053302.47233527
9Autoimmune thyroid disease_Homo sapiens_hsa053202.37990202
10Type I diabetes mellitus_Homo sapiens_hsa049402.31718367
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.28758872
12Primary immunodeficiency_Homo sapiens_hsa053402.25569845
13Collecting duct acid secretion_Homo sapiens_hsa049662.05871708
14RNA polymerase_Homo sapiens_hsa030201.97293290
15Huntingtons disease_Homo sapiens_hsa050161.94016850
16Alzheimers disease_Homo sapiens_hsa050101.93465137
17Phototransduction_Homo sapiens_hsa047441.82568944
18Rheumatoid arthritis_Homo sapiens_hsa053231.77428453
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70782542
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.66151329
21Antigen processing and presentation_Homo sapiens_hsa046121.62736201
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55850083
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53858585
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48416645
25Sulfur metabolism_Homo sapiens_hsa009201.41535248
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.39076516
27Systemic lupus erythematosus_Homo sapiens_hsa053221.35869682
28Viral myocarditis_Homo sapiens_hsa054161.30403569
29Cardiac muscle contraction_Homo sapiens_hsa042601.22954664
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21504924
31Regulation of autophagy_Homo sapiens_hsa041401.20450535
32Fatty acid elongation_Homo sapiens_hsa000621.16621650
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13019160
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10746640
35RNA degradation_Homo sapiens_hsa030181.10355472
36Peroxisome_Homo sapiens_hsa041461.09543888
37Pyrimidine metabolism_Homo sapiens_hsa002401.05763955
38Butanoate metabolism_Homo sapiens_hsa006501.04793905
39Ribosome_Homo sapiens_hsa030101.02869461
40Linoleic acid metabolism_Homo sapiens_hsa005910.98851801
41Basal transcription factors_Homo sapiens_hsa030220.95300707
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93245107
43Hematopoietic cell lineage_Homo sapiens_hsa046400.92230799
44Synaptic vesicle cycle_Homo sapiens_hsa047210.91333919
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91298226
46Vibrio cholerae infection_Homo sapiens_hsa051100.90183061
47Base excision repair_Homo sapiens_hsa034100.88987507
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85712607
49Homologous recombination_Homo sapiens_hsa034400.84240062
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82085695
51Propanoate metabolism_Homo sapiens_hsa006400.81590151
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81040136
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78693707
54Purine metabolism_Homo sapiens_hsa002300.77994371
55Shigellosis_Homo sapiens_hsa051310.75691224
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75491427
57Nitrogen metabolism_Homo sapiens_hsa009100.74838700
58Phagosome_Homo sapiens_hsa041450.74271722
59Nicotine addiction_Homo sapiens_hsa050330.74183687
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71843939
61Ether lipid metabolism_Homo sapiens_hsa005650.70364137
62Selenocompound metabolism_Homo sapiens_hsa004500.69993793
63Alcoholism_Homo sapiens_hsa050340.66515514
64Spliceosome_Homo sapiens_hsa030400.66387788
65Metabolic pathways_Homo sapiens_hsa011000.66340313
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65941060
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65478740
68Legionellosis_Homo sapiens_hsa051340.65118782
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64390746
70Fanconi anemia pathway_Homo sapiens_hsa034600.61378721
71Olfactory transduction_Homo sapiens_hsa047400.60492412
72Arachidonic acid metabolism_Homo sapiens_hsa005900.59800532
73Steroid biosynthesis_Homo sapiens_hsa001000.59544723
74Sulfur relay system_Homo sapiens_hsa041220.58014826
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55095872
76GABAergic synapse_Homo sapiens_hsa047270.54773677
77Staphylococcus aureus infection_Homo sapiens_hsa051500.54071936
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53418733
79Tryptophan metabolism_Homo sapiens_hsa003800.52646764
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51888809
81Herpes simplex infection_Homo sapiens_hsa051680.51077064
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48943217
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48167816
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47410805
85Salmonella infection_Homo sapiens_hsa051320.47181341
86NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45453633
87Leishmaniasis_Homo sapiens_hsa051400.44249988
88Morphine addiction_Homo sapiens_hsa050320.44245757
89Taste transduction_Homo sapiens_hsa047420.43718466
90RNA transport_Homo sapiens_hsa030130.42894298
91Chemical carcinogenesis_Homo sapiens_hsa052040.37459943
92Tuberculosis_Homo sapiens_hsa051520.35791428
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35153939
94Epstein-Barr virus infection_Homo sapiens_hsa051690.34950761
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29393985
96beta-Alanine metabolism_Homo sapiens_hsa004100.29182631
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.29177247
98Glutathione metabolism_Homo sapiens_hsa004800.28458060
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26837705
100Non-homologous end-joining_Homo sapiens_hsa034500.26049072

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