ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.85047026
2	platelet dense granule organization (GO:0060155)	4.55948929
3	iron-sulfur cluster assembly (GO:0016226)	4.40113199
4	metallo-sulfur cluster assembly (GO:0031163)	4.40113199
5	protein-cofactor linkage (GO:0018065)	4.32621975
6	positive regulation of mitochondrial fission (GO:0090141)	4.11697514
7	protein complex biogenesis (GO:0070271)	4.05250297
8	sequestering of actin monomers (GO:0042989)	4.01371708
9	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.90796527
10	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.88453217
11	NADH dehydrogenase complex assembly (GO:0010257)	3.88453217
12	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.88453217
13	proteasome assembly (GO:0043248)	3.86818885
14	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.82025138
15	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.82025138
16	mannosylation (GO:0097502)	3.77125394
17	GPI anchor metabolic process (GO:0006505)	3.74231152
18	base-excision repair, AP site formation (GO:0006285)	3.73484181
19	protein neddylation (GO:0045116)	3.72749275
20	cytidine deamination (GO:0009972)	3.72124134
21	cytidine metabolic process (GO:0046087)	3.72124134
22	cytidine catabolic process (GO:0006216)	3.72124134
23	mitochondrial respiratory chain complex assembly (GO:0033108)	3.66883121
24	GPI anchor biosynthetic process (GO:0006506)	3.62804813
25	ATP synthesis coupled proton transport (GO:0015986)	3.59482568
26	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.59482568
27	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.58685502
28	preassembly of GPI anchor in ER membrane (GO:0016254)	3.57128526
29	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.50194899
30	actin nucleation (GO:0045010)	3.44379066
31	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.43139703
32	respiratory electron transport chain (GO:0022904)	3.28214153
33	electron transport chain (GO:0022900)	3.25026023
34	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.24789158
35	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.22474902
36	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.19051593
37	respiratory chain complex IV assembly (GO:0008535)	3.17283551
38	regulation of cellular amino acid metabolic process (GO:0006521)	3.08438148
39	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.06579672
40	protein deneddylation (GO:0000338)	3.05083223
41	C-terminal protein lipidation (GO:0006501)	3.04800283
42	chaperone-mediated protein transport (GO:0072321)	3.00340295
43	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.00032172
44	purine deoxyribonucleotide catabolic process (GO:0009155)	2.98718131
45	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.97775663
46	cullin deneddylation (GO:0010388)	2.94700825
47	regulation of mitochondrial fission (GO:0090140)	2.94121149
48	deoxyribonucleotide catabolic process (GO:0009264)	2.92621258
49	C-terminal protein amino acid modification (GO:0018410)	2.85544480
50	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.83908808
51	ATP hydrolysis coupled proton transport (GO:0015991)	2.83607267
52	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.83607267
53	L-methionine salvage (GO:0071267)	2.78103515
54	L-methionine biosynthetic process (GO:0071265)	2.78103515
55	amino acid salvage (GO:0043102)	2.78103515
56	hydrogen ion transmembrane transport (GO:1902600)	2.76414140
57	deoxyribose phosphate catabolic process (GO:0046386)	2.75685631
58	proton transport (GO:0015992)	2.75102382
59	negative regulation of telomere maintenance (GO:0032205)	2.73465605
60	cytochrome complex assembly (GO:0017004)	2.72300104
61	hydrogen transport (GO:0006818)	2.71676777
62	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.69801687
63	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.69801687
64	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.69801687
65	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.68351161
66	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.68351161
67	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.67398020
68	anterograde synaptic vesicle transport (GO:0048490)	2.66671142
69	adenosine metabolic process (GO:0046085)	2.63265160
70	glycolipid biosynthetic process (GO:0009247)	2.62082785
71	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.58042063
72	ubiquinone biosynthetic process (GO:0006744)	2.57984834
73	piRNA metabolic process (GO:0034587)	2.56930858
74	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.56425553
75	pyrimidine nucleotide catabolic process (GO:0006244)	2.54892900
76	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.54033771
77	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.53267207
78	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.52375320
79	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.52375320
80	purine deoxyribonucleotide metabolic process (GO:0009151)	2.50754607
81	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.50522791
82	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.49431131
83	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.49206262
84	negative regulation of mast cell activation (GO:0033004)	2.48733255
85	response to pheromone (GO:0019236)	2.46880016
86	pyrimidine-containing compound catabolic process (GO:0072529)	2.46010262
87	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.43612399
88	termination of RNA polymerase III transcription (GO:0006386)	2.43612399
89	2-deoxyribonucleotide metabolic process (GO:0009394)	2.43351385
90	positive regulation of interleukin-8 secretion (GO:2000484)	2.42659102
91	peptidyl-histidine modification (GO:0018202)	2.40019016
92	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.39705066
93	ubiquinone metabolic process (GO:0006743)	2.39102689
94	pyrimidine nucleobase catabolic process (GO:0006208)	2.39084237
95	peroxisome fission (GO:0016559)	2.38806949
96	negative regulation of membrane potential (GO:0045837)	2.37684924
97	tRNA processing (GO:0008033)	2.37460598
98	protein localization to cilium (GO:0061512)	2.37338097
99	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.37221968
100	positive regulation of prostaglandin secretion (GO:0032308)	2.36459011

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.17684744
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.94081183
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.78185531
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.64558262
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.21049832
6	ZNF274_21170338_ChIP-Seq_K562_Hela	3.08335330
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.06563610
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.03440669
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.92561858
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.70732636
11	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.58665612
12	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.52548814
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.52378373
14	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.46366761
15	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.18848018
16	FOXP3_21729870_ChIP-Seq_TREG_Human	2.16995956
17	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.16743223
18	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.13859664
19	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.13106671
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.08770811
21	ELK1_19687146_ChIP-ChIP_HELA_Human	2.07764726
22	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.05884996
23	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.95105944
24	VDR_22108803_ChIP-Seq_LS180_Human	1.84151499
25	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.83876092
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.82668964
27	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.80142803
28	GABP_19822575_ChIP-Seq_HepG2_Human	1.73031730
29	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.66777398
30	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.65445643
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.64469068
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.61326188
33	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.56832868
34	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.55101494
35	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.53202330
36	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.52281140
37	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.51633757
38	TAF15_26573619_Chip-Seq_HEK293_Human	1.51251201
39	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.49482842
40	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.44508115
41	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.44038164
42	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.42173272
43	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.42136109
44	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.40819977
45	DCP1A_22483619_ChIP-Seq_HELA_Human	1.35720352
46	GATA3_26560356_Chip-Seq_TH2_Human	1.34932924
47	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.34159972
48	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.32069602
49	CIITA_25753668_ChIP-Seq_RAJI_Human	1.27935790
50	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.27559724
51	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.24223311
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23874860
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23874860
54	AR_20517297_ChIP-Seq_VCAP_Human	1.18236720
55	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.17800454
56	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.15506266
57	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.14020508
58	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.13004971
59	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.12888705
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.11585216
61	NCOR_22424771_ChIP-Seq_293T_Human	1.11056390
62	GBX2_23144817_ChIP-Seq_PC3_Human	1.10957361
63	* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.10808797
64	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.10421982
65	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.09024290
66	EWS_26573619_Chip-Seq_HEK293_Human	1.08552473
67	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.07542634
68	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.04990435
69	* P300_19829295_ChIP-Seq_ESCs_Human	1.04046042
70	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.03774576
71	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03624352
72	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.03504430
73	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.02858296
74	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.01257376
75	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.00980794
76	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.00696196
77	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99364726
78	NANOG_19829295_ChIP-Seq_ESCs_Human	0.98898297
79	SOX2_19829295_ChIP-Seq_ESCs_Human	0.98898297
80	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.98797940
81	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97760497
82	HTT_18923047_ChIP-ChIP_STHdh_Human	0.97198208
83	TAF2_19829295_ChIP-Seq_ESCs_Human	0.96751502
84	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96345729
85	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.95736042
86	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.95300665
87	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.95132139
88	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.94878703
89	MYC_19829295_ChIP-Seq_ESCs_Human	0.94247740
90	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.94035930
91	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.94021200
92	GATA3_27048872_Chip-Seq_THYMUS_Human	0.93954569
93	* MYB_26560356_Chip-Seq_TH2_Human	0.93276106
94	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.92182114
95	CBP_20019798_ChIP-Seq_JUKART_Human	0.91740030
96	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.91740030
97	TTF2_22483619_ChIP-Seq_HELA_Human	0.91663298
98	BCL6_27268052_Chip-Seq_Bcells_Human	0.91245409
99	* SPI1_23547873_ChIP-Seq_NB4_Human	0.90599455
100	EZH2_22144423_ChIP-Seq_EOC_Human	0.89567935

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.23896545
2	MP0004147_increased_porphyrin_level	3.12540985
3	MP0002102_abnormal_ear_morphology	3.00333319
4	MP0001835_abnormal_antigen_presentation	2.60364800
5	MP0006072_abnormal_retinal_apoptosis	2.35858584
6	MP0001529_abnormal_vocalization	2.31164396
7	MP0005645_abnormal_hypothalamus_physiol	2.28441617
8	MP0009785_altered_susceptibility_to	2.11279442
9	MP0008877_abnormal_DNA_methylation	2.10798589
10	MP0005084_abnormal_gallbladder_morpholo	2.01990849
11	MP0008995_early_reproductive_senescence	1.97550711
12	MP0001905_abnormal_dopamine_level	1.95212967
13	MP0003724_increased_susceptibility_to	1.92305492
14	MP0002653_abnormal_ependyma_morphology	1.92146125
15	MP0006276_abnormal_autonomic_nervous	1.81074163
16	MP0001984_abnormal_olfaction	1.78501497
17	MP0000372_irregular_coat_pigmentation	1.77754262
18	MP0009046_muscle_twitch	1.73145594
19	MP0002837_dystrophic_cardiac_calcinosis	1.72553312
20	MP0006036_abnormal_mitochondrial_physio	1.71145489
21	MP0005253_abnormal_eye_physiology	1.70080219
22	MP0003806_abnormal_nucleotide_metabolis	1.70068991
23	MP0009764_decreased_sensitivity_to	1.69875409
24	MP0002148_abnormal_hypersensitivity_rea	1.69530097
25	MP0001968_abnormal_touch/_nociception	1.66776511
26	MP0003011_delayed_dark_adaptation	1.64305369
27	MP0005551_abnormal_eye_electrophysiolog	1.61452401
28	MP0003786_premature_aging	1.59805166
29	MP0003880_abnormal_central_pattern	1.57336784
30	MP0001986_abnormal_taste_sensitivity	1.56981196
31	MP0004142_abnormal_muscle_tone	1.55919282
32	MP0006035_abnormal_mitochondrial_morpho	1.51818485
33	MP0001800_abnormal_humoral_immune	1.51125736
34	MP0002736_abnormal_nociception_after	1.48766419
35	MP0005075_abnormal_melanosome_morpholog	1.46218279
36	MP0005000_abnormal_immune_tolerance	1.44812604
37	MP0008872_abnormal_physiological_respon	1.44436431
38	MP0008058_abnormal_DNA_repair	1.40941194
39	MP0002723_abnormal_immune_serum	1.40838853
40	MP0003646_muscle_fatigue	1.38460090
41	MP0003186_abnormal_redox_activity	1.33953094
42	MP0002822_catalepsy	1.33029303
43	MP0008789_abnormal_olfactory_epithelium	1.32453082
44	MP0005646_abnormal_pituitary_gland	1.29857209
45	MP0009745_abnormal_behavioral_response	1.29729050
46	MP0002452_abnormal_antigen_presenting	1.27310373
47	MP0001819_abnormal_immune_cell	1.24556710
48	MP0005394_taste/olfaction_phenotype	1.24310902
49	MP0005499_abnormal_olfactory_system	1.24310902
50	MP0001764_abnormal_homeostasis	1.23649801
51	MP0002420_abnormal_adaptive_immunity	1.23644069
52	MP0002277_abnormal_respiratory_mucosa	1.23156260
53	MP0002876_abnormal_thyroid_physiology	1.21364862
54	MP0000516_abnormal_urinary_system	1.19312446
55	MP0005367_renal/urinary_system_phenotyp	1.19312446
56	MP0002272_abnormal_nervous_system	1.17103432
57	MP0003195_calcinosis	1.14534878
58	MP0005025_abnormal_response_to	1.14481499
59	MP0005387_immune_system_phenotype	1.13350881
60	MP0001790_abnormal_immune_system	1.13350881
61	MP0008875_abnormal_xenobiotic_pharmacok	1.13049292
62	MP0000685_abnormal_immune_system	1.09201770
63	MP0003122_maternal_imprinting	1.08709254
64	MP0003787_abnormal_imprinting	1.00411497
65	MP0001501_abnormal_sleep_pattern	0.96784111
66	MP0002234_abnormal_pharynx_morphology	0.96663369
67	MP0001919_abnormal_reproductive_system	0.95429568
68	MP0000465_gastrointestinal_hemorrhage	0.94740037
69	MP0000716_abnormal_immune_system	0.93467755
70	MP0005410_abnormal_fertilization	0.92618962
71	MP0003718_maternal_effect	0.89160658
72	MP0000631_abnormal_neuroendocrine_gland	0.88573488
73	MP0001970_abnormal_pain_threshold	0.86691945
74	MP0002163_abnormal_gland_morphology	0.85164875
75	MP0005379_endocrine/exocrine_gland_phen	0.85144483
76	MP0001845_abnormal_inflammatory_respons	0.84893576
77	MP0002572_abnormal_emotion/affect_behav	0.84611793
78	MP0002733_abnormal_thermal_nociception	0.83837148
79	MP0000689_abnormal_spleen_morphology	0.83830814
80	MP0009765_abnormal_xenobiotic_induced	0.83557235
81	MP0005386_behavior/neurological_phenoty	0.83005992
82	MP0004924_abnormal_behavior	0.83005992
83	MP0009763_increased_sensitivity_to	0.82756406
84	MP0005389_reproductive_system_phenotype	0.82306301
85	MP0002751_abnormal_autonomic_nervous	0.82306130
86	MP0002095_abnormal_skin_pigmentation	0.81409963
87	MP0005332_abnormal_amino_acid	0.80632783
88	MP0003121_genomic_imprinting	0.80450712
89	MP0006082_CNS_inflammation	0.80108517
90	MP0002638_abnormal_pupillary_reflex	0.79994734
91	MP0002419_abnormal_innate_immunity	0.79891017
92	MP0001188_hyperpigmentation	0.79497794
93	MP0001542_abnormal_bone_strength	0.79311142
94	MP0003763_abnormal_thymus_physiology	0.78836311
95	MP0002398_abnormal_bone_marrow	0.77985275
96	MP0003866_abnormal_defecation	0.77510796
97	MP0001502_abnormal_circadian_rhythm	0.75876130
98	MP0002332_abnormal_exercise_endurance	0.73954415
99	MP0005636_abnormal_mineral_homeostasis	0.73811691
100	MP0002735_abnormal_chemical_nociception	0.73739159

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Mitochondrial inheritance (HP:0001427)	4.05225335
2	Acute necrotizing encephalopathy (HP:0006965)	4.00554910
3	Abnormal mitochondria in muscle tissue (HP:0008316)	3.94242375
4	Hepatocellular necrosis (HP:0001404)	3.93997035
5	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.91728048
6	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.91728048
7	Increased CSF lactate (HP:0002490)	3.75651431
8	Hepatic necrosis (HP:0002605)	3.74015042
9	3-Methylglutaconic aciduria (HP:0003535)	3.71188905
10	Acute encephalopathy (HP:0006846)	3.50367126
11	Progressive macrocephaly (HP:0004481)	3.37951645
12	Increased hepatocellular lipid droplets (HP:0006565)	3.20974194
13	Increased intramyocellular lipid droplets (HP:0012240)	3.20048168
14	Lipid accumulation in hepatocytes (HP:0006561)	3.14158770
15	Pancreatic cysts (HP:0001737)	3.06123366
16	Renal Fanconi syndrome (HP:0001994)	2.97125200
17	Increased serum lactate (HP:0002151)	2.85022873
18	Lactic acidosis (HP:0003128)	2.79569068
19	Increased muscle lipid content (HP:0009058)	2.79100597
20	Medial flaring of the eyebrow (HP:0010747)	2.73131545
21	IgG deficiency (HP:0004315)	2.66787017
22	Type II lissencephaly (HP:0007260)	2.66225475
23	Abolished electroretinogram (ERG) (HP:0000550)	2.64852448
24	Retinal dysplasia (HP:0007973)	2.59012969
25	Renal cortical cysts (HP:0000803)	2.56619150
26	Type I transferrin isoform profile (HP:0003642)	2.56496034
27	Pancreatic fibrosis (HP:0100732)	2.55536565
28	True hermaphroditism (HP:0010459)	2.51588774
29	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.50284555
30	Abnormal protein N-linked glycosylation (HP:0012347)	2.50284555
31	Abnormal protein glycosylation (HP:0012346)	2.50284555
32	Abnormal glycosylation (HP:0012345)	2.50284555
33	Generalized aminoaciduria (HP:0002909)	2.46788771
34	Cerebral edema (HP:0002181)	2.45640519
35	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.43368842
36	Abnormality of midbrain morphology (HP:0002418)	2.41099277
37	Molar tooth sign on MRI (HP:0002419)	2.41099277
38	Hyperglycinemia (HP:0002154)	2.40927923
39	Methylmalonic acidemia (HP:0002912)	2.36157584
40	Congenital stationary night blindness (HP:0007642)	2.36054688
41	Optic disc pallor (HP:0000543)	2.35418518
42	Aplasia/hypoplasia of the uterus (HP:0008684)	2.34965093
43	Severe combined immunodeficiency (HP:0004430)	2.34394839
44	Exertional dyspnea (HP:0002875)	2.34237450
45	Elevated erythrocyte sedimentation rate (HP:0003565)	2.32850779
46	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.32087582
47	Lissencephaly (HP:0001339)	2.28061232
48	Stomatitis (HP:0010280)	2.27888726
49	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.26899785
50	Methylmalonic aciduria (HP:0012120)	2.26321603
51	Congenital primary aphakia (HP:0007707)	2.21051922
52	Gait imbalance (HP:0002141)	2.20561051
53	Aplastic anemia (HP:0001915)	2.19991562
54	Delayed CNS myelination (HP:0002188)	2.19795680
55	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.19021175
56	Amyotrophic lateral sclerosis (HP:0007354)	2.14865883
57	Respiratory failure (HP:0002878)	2.13263778
58	Nephrogenic diabetes insipidus (HP:0009806)	2.12454790
59	Emotional lability (HP:0000712)	2.10140052
60	Progressive microcephaly (HP:0000253)	2.08771442
61	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.08499275
62	Abnormality of alanine metabolism (HP:0010916)	2.08499275
63	Hyperalaninemia (HP:0003348)	2.08499275
64	Exercise intolerance (HP:0003546)	2.06015896
65	Polyphagia (HP:0002591)	2.04993992
66	Lethargy (HP:0001254)	2.04665925
67	CNS demyelination (HP:0007305)	2.03816269
68	Increased IgM level (HP:0003496)	2.01168904
69	Abnormality of urine glucose concentration (HP:0011016)	2.00731779
70	Glycosuria (HP:0003076)	2.00731779
71	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.97957137
72	Dicarboxylic aciduria (HP:0003215)	1.97957137
73	Short tibia (HP:0005736)	1.97929455
74	Hypothermia (HP:0002045)	1.93500414
75	Thyroiditis (HP:0100646)	1.91686088
76	Attenuation of retinal blood vessels (HP:0007843)	1.90880352
77	Abnormality of the renal cortex (HP:0011035)	1.90789286
78	Degeneration of anterior horn cells (HP:0002398)	1.88361549
79	Abnormality of the anterior horn cell (HP:0006802)	1.88361549
80	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.88041822
81	Sclerocornea (HP:0000647)	1.86447241
82	Abnormality of renal resorption (HP:0011038)	1.84783610
83	Hypoproteinemia (HP:0003075)	1.83652451
84	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.82983037
85	Abnormality of the prostate (HP:0008775)	1.81912552
86	Abnormality of eosinophils (HP:0001879)	1.81409949
87	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.80457762
88	Failure to thrive in infancy (HP:0001531)	1.79480436
89	Inability to walk (HP:0002540)	1.76753251
90	Pachygyria (HP:0001302)	1.76689305
91	Progressive inability to walk (HP:0002505)	1.74448903
92	Abnormal rod and cone electroretinograms (HP:0008323)	1.73410496
93	Cerebral palsy (HP:0100021)	1.72980634
94	Pendular nystagmus (HP:0012043)	1.70487053
95	Increased serum pyruvate (HP:0003542)	1.69976683
96	Ketoacidosis (HP:0001993)	1.69917858
97	Nephronophthisis (HP:0000090)	1.68742585
98	Acute hepatic failure (HP:0006554)	1.68432964
99	Ketosis (HP:0001946)	1.68331810
100	Hypoplasia of the uterus (HP:0000013)	1.66425744

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	4.41054361
2	MAP4K2	4.25657751
3	BCKDK	3.46378914
4	TAOK3	2.51380497
5	TRIM28	2.43654205
6	TXK	2.39660443
7	BCR	2.20790290
8	KDR	2.14360048
9	ZAK	2.08440212
10	CDK19	2.01251638
11	CSNK1G3	1.98474735
12	FRK	1.95811000
13	TLK1	1.95719672
14	LIMK1	1.81182762
15	MAP2K7	1.79844306
16	PINK1	1.71145754
17	TESK1	1.70744816
18	WNK3	1.70609392
19	CSNK1G2	1.69123829
20	CSNK1A1L	1.68669223
21	ADRBK2	1.68548891
22	GRK1	1.59327502
23	NUAK1	1.52243331
24	VRK2	1.48304538
25	CSNK1G1	1.46997436
26	ERBB3	1.41685266
27	VRK1	1.41090694
28	MAP3K4	1.38181668
29	MAPK13	1.33613491
30	MAP3K12	1.31718683
31	SRPK1	1.31525480
32	PIM2	1.30693757
33	INSRR	1.24719673
34	RPS6KA5	1.16365310
35	DYRK2	1.15419568
36	MAP4K1	0.96870453
37	IKBKB	0.96557192
38	OXSR1	0.94649658
39	GRK6	0.92738388
40	EIF2AK3	0.90723549
41	IKBKE	0.86741827
42	SIK3	0.85934558
43	STK16	0.84351662
44	EPHA3	0.84051346
45	RPS6KA4	0.83890160
46	SYK	0.81133544
47	DAPK1	0.79008564
48	CCNB1	0.78895080
49	TEC	0.78780987
50	DYRK3	0.77172346
51	TIE1	0.76025002
52	MAP3K5	0.75304953
53	BMPR2	0.74978025
54	TBK1	0.74706713
55	ITK	0.74355234
56	LYN	0.72982505
57	FES	0.72629965
58	GRK7	0.71984742
59	MINK1	0.70401528
60	KIT	0.70126498
61	MARK1	0.70035394
62	PRKCE	0.69283808
63	PLK2	0.68518391
64	MST4	0.68329789
65	FLT3	0.66324895
66	PRKCQ	0.63263714
67	DAPK2	0.62563265
68	BMPR1B	0.61205096
69	SCYL2	0.60645645
70	MAPKAPK3	0.60572358
71	CSF1R	0.60106841
72	PAK3	0.57115117
73	ADRBK1	0.56665844
74	WNK4	0.55162883
75	MAP3K11	0.53712529
76	PHKG1	0.53627560
77	PHKG2	0.53627560
78	ARAF	0.52186905
79	DAPK3	0.49317522
80	BUB1	0.48664515
81	LCK	0.48662967
82	MATK	0.48569983
83	PTK2B	0.47730680
84	CSNK2A1	0.43238056
85	PLK4	0.42015555
86	AURKA	0.41252771
87	MYLK	0.41246089
88	CSNK1A1	0.40777822
89	PRKACA	0.40038146
90	GRK5	0.39874967
91	BTK	0.38480931
92	MUSK	0.36885028
93	PIK3CG	0.35821567
94	ABL1	0.35784197
95	JAK3	0.35069311
96	CAMK2A	0.34810807
97	DYRK1B	0.34534498
98	PIM1	0.33745795
99	ABL2	0.33605898
100	IGF1R	0.31781030

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.87596457
2	Proteasome_Homo sapiens_hsa03050	3.47794111
3	Parkinsons disease_Homo sapiens_hsa05012	3.18153378
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.93410266
5	Protein export_Homo sapiens_hsa03060	2.82352118
6	Asthma_Homo sapiens_hsa05310	2.62126979
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.48350008
8	Allograft rejection_Homo sapiens_hsa05330	2.47233527
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.37990202
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.31718367
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.28758872
12	Primary immunodeficiency_Homo sapiens_hsa05340	2.25569845
13	Collecting duct acid secretion_Homo sapiens_hsa04966	2.05871708
14	RNA polymerase_Homo sapiens_hsa03020	1.97293290
15	Huntingtons disease_Homo sapiens_hsa05016	1.94016850
16	Alzheimers disease_Homo sapiens_hsa05010	1.93465137
17	Phototransduction_Homo sapiens_hsa04744	1.82568944
18	Rheumatoid arthritis_Homo sapiens_hsa05323	1.77428453
19	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.70782542
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.66151329
21	Antigen processing and presentation_Homo sapiens_hsa04612	1.62736201
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.55850083
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.53858585
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.48416645
25	Sulfur metabolism_Homo sapiens_hsa00920	1.41535248
26	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.39076516
27	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.35869682
28	Viral myocarditis_Homo sapiens_hsa05416	1.30403569
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.22954664
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.21504924
31	Regulation of autophagy_Homo sapiens_hsa04140	1.20450535
32	Fatty acid elongation_Homo sapiens_hsa00062	1.16621650
33	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.13019160
34	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.10746640
35	RNA degradation_Homo sapiens_hsa03018	1.10355472
36	Peroxisome_Homo sapiens_hsa04146	1.09543888
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.05763955
38	Butanoate metabolism_Homo sapiens_hsa00650	1.04793905
39	Ribosome_Homo sapiens_hsa03010	1.02869461
40	Linoleic acid metabolism_Homo sapiens_hsa00591	0.98851801
41	Basal transcription factors_Homo sapiens_hsa03022	0.95300707
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.93245107
43	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.92230799
44	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.91333919
45	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.91298226
46	Vibrio cholerae infection_Homo sapiens_hsa05110	0.90183061
47	Base excision repair_Homo sapiens_hsa03410	0.88987507
48	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.85712607
49	Homologous recombination_Homo sapiens_hsa03440	0.84240062
50	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.82085695
51	Propanoate metabolism_Homo sapiens_hsa00640	0.81590151
52	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.81040136
53	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.78693707
54	Purine metabolism_Homo sapiens_hsa00230	0.77994371
55	Shigellosis_Homo sapiens_hsa05131	0.75691224
56	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.75491427
57	Nitrogen metabolism_Homo sapiens_hsa00910	0.74838700
58	Phagosome_Homo sapiens_hsa04145	0.74271722
59	Nicotine addiction_Homo sapiens_hsa05033	0.74183687
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.71843939
61	Ether lipid metabolism_Homo sapiens_hsa00565	0.70364137
62	Selenocompound metabolism_Homo sapiens_hsa00450	0.69993793
63	Alcoholism_Homo sapiens_hsa05034	0.66515514
64	Spliceosome_Homo sapiens_hsa03040	0.66387788
65	Metabolic pathways_Homo sapiens_hsa01100	0.66340313
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.65941060
67	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.65478740
68	Legionellosis_Homo sapiens_hsa05134	0.65118782
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.64390746
70	Fanconi anemia pathway_Homo sapiens_hsa03460	0.61378721
71	Olfactory transduction_Homo sapiens_hsa04740	0.60492412
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59800532
73	Steroid biosynthesis_Homo sapiens_hsa00100	0.59544723
74	Sulfur relay system_Homo sapiens_hsa04122	0.58014826
75	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.55095872
76	GABAergic synapse_Homo sapiens_hsa04727	0.54773677
77	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.54071936
78	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.53418733
79	Tryptophan metabolism_Homo sapiens_hsa00380	0.52646764
80	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.51888809
81	Herpes simplex infection_Homo sapiens_hsa05168	0.51077064
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.48943217
83	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.48167816
84	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.47410805
85	Salmonella infection_Homo sapiens_hsa05132	0.47181341
86	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.45453633
87	Leishmaniasis_Homo sapiens_hsa05140	0.44249988
88	Morphine addiction_Homo sapiens_hsa05032	0.44245757
89	Taste transduction_Homo sapiens_hsa04742	0.43718466
90	RNA transport_Homo sapiens_hsa03013	0.42894298
91	Chemical carcinogenesis_Homo sapiens_hsa05204	0.37459943
92	Tuberculosis_Homo sapiens_hsa05152	0.35791428
93	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.35153939
94	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.34950761
95	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.29393985
96	beta-Alanine metabolism_Homo sapiens_hsa00410	0.29182631
97	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.29177247
98	Glutathione metabolism_Homo sapiens_hsa00480	0.28458060
99	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.26837705
100	Non-homologous end-joining_Homo sapiens_hsa03450	0.26049072

MAP1LC3B2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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