ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sphingosine metabolic process (GO:0006670)	7.29726915
2	diol metabolic process (GO:0034311)	6.83325008
3	sphingoid metabolic process (GO:0046519)	6.29128973
4	response to pheromone (GO:0019236)	5.49305415
5	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	5.32597817
6	DNA methylation involved in gamete generation (GO:0043046)	4.82408785
7	regulation of protein glycosylation (GO:0060049)	4.62322396
8	piRNA metabolic process (GO:0034587)	4.56465981
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.53858955
10	regulation of meiosis I (GO:0060631)	4.52649692
11	heparin biosynthetic process (GO:0030210)	4.48726855
12	heparin metabolic process (GO:0030202)	4.48726855
13	protein-chromophore linkage (GO:0018298)	4.37276046
14	positive regulation of sodium ion transmembrane transport (GO:1902307)	4.36981315
15	positive regulation of mitochondrial fission (GO:0090141)	4.34034236
16	adult feeding behavior (GO:0008343)	4.29616243
17	regulation of rhodopsin mediated signaling pathway (GO:0022400)	4.23059428
18	lipopolysaccharide biosynthetic process (GO:0009103)	4.17379455
19	sulfate transmembrane transport (GO:1902358)	3.92239289
20	positive regulation of developmental pigmentation (GO:0048087)	3.88182600
21	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	3.87823989
22	rhodopsin mediated signaling pathway (GO:0016056)	3.83318750
23	cellular response to exogenous dsRNA (GO:0071360)	3.80511273
24	L-phenylalanine catabolic process (GO:0006559)	3.76915798
25	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.76915798
26	lipopolysaccharide metabolic process (GO:0008653)	3.67661597
27	epithelial cilium movement (GO:0003351)	3.67113172
28	auditory receptor cell stereocilium organization (GO:0060088)	3.61981024
29	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.60823390
30	behavioral response to nicotine (GO:0035095)	3.58727276
31	regulation of cilium movement (GO:0003352)	3.55973139
32	urate metabolic process (GO:0046415)	3.55711374
33	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	3.54382686
34	cilium movement (GO:0003341)	3.48805703
35	behavioral response to ethanol (GO:0048149)	3.46984226
36	inositol metabolic process (GO:0006020)	3.46329212
37	negative regulation of interleukin-1 beta production (GO:0032691)	3.42789914
38	sulfate transport (GO:0008272)	3.42090617
39	protein K11-linked deubiquitination (GO:0035871)	3.39288412
40	regulation of mitochondrial fission (GO:0090140)	3.38017847
41	inner ear receptor stereocilium organization (GO:0060122)	3.33400954
42	aspartate family amino acid catabolic process (GO:0009068)	3.29015867
43	retinal cone cell development (GO:0046549)	3.22817271
44	indolalkylamine metabolic process (GO:0006586)	3.22476298
45	axoneme assembly (GO:0035082)	3.21908478
46	positive regulation of meiosis (GO:0045836)	3.21860681
47	dicarboxylic acid catabolic process (GO:0043649)	3.16932448
48	growth hormone secretion (GO:0030252)	3.15361566
49	axonemal dynein complex assembly (GO:0070286)	3.15128330
50	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	3.14790351
51	C4-dicarboxylate transport (GO:0015740)	3.11442828
52	one-carbon compound transport (GO:0019755)	3.06147629
53	adaptation of signaling pathway (GO:0023058)	2.99556622
54	retinal rod cell development (GO:0046548)	2.99250021
55	regulation of pigment cell differentiation (GO:0050932)	2.97474304
56	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.96118650
57	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.96118650
58	positive regulation of meiotic cell cycle (GO:0051446)	2.95904841
59	kidney morphogenesis (GO:0060993)	2.94401640
60	aromatic amino acid family catabolic process (GO:0009074)	2.94183194
61	mannosylation (GO:0097502)	2.94124449
62	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.93577070
63	NAD biosynthetic process (GO:0009435)	2.89548526
64	proline transport (GO:0015824)	2.86910100
65	negative regulation of interleukin-1 production (GO:0032692)	2.86722135
66	regulation of microtubule-based movement (GO:0060632)	2.86400971
67	hindbrain development (GO:0030902)	2.84250217
68	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.83416055
69	L-phenylalanine metabolic process (GO:0006558)	2.83416055
70	cilium or flagellum-dependent cell motility (GO:0001539)	2.82996708
71	sperm motility (GO:0030317)	2.82504908
72	reciprocal DNA recombination (GO:0035825)	2.81311372
73	reciprocal meiotic recombination (GO:0007131)	2.81311372
74	DNA deamination (GO:0045006)	2.78106122
75	ubiquinone biosynthetic process (GO:0006744)	2.74708038
76	mitochondrial fission (GO:0000266)	2.74286970
77	eye photoreceptor cell differentiation (GO:0001754)	2.73184858
78	photoreceptor cell differentiation (GO:0046530)	2.73184858
79	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.73162453
80	negative regulation of cell cycle G2/M phase transition (GO:1902750)	2.72912958
81	cilium organization (GO:0044782)	2.72186938
82	regulation of appetite (GO:0032098)	2.71595007
83	negative regulation of systemic arterial blood pressure (GO:0003085)	2.71183222
84	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.68509283
85	spermatid development (GO:0007286)	2.68198998
86	regulation of response to food (GO:0032095)	2.67631790
87	pantothenate metabolic process (GO:0015939)	2.66901269
88	photoreceptor cell maintenance (GO:0045494)	2.66073545
89	male meiosis I (GO:0007141)	2.65430865
90	regulation of developmental pigmentation (GO:0048070)	2.60885611
91	platelet dense granule organization (GO:0060155)	2.60647858
92	cilium assembly (GO:0042384)	2.57990376
93	regulation of neurotransmitter uptake (GO:0051580)	2.57308758
94	heme transport (GO:0015886)	2.56946494
95	methionine biosynthetic process (GO:0009086)	2.55855088
96	seminiferous tubule development (GO:0072520)	2.51572515
97	ubiquinone metabolic process (GO:0006743)	2.49874126
98	acrosome assembly (GO:0001675)	2.49449705
99	negative regulation of telomere maintenance (GO:0032205)	2.49130917
100	multicellular organism reproduction (GO:0032504)	2.46568747

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.21076286
2	IGF1R_20145208_ChIP-Seq_DFB_Human	3.85535045
3	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.11503264
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.95805089
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.93933004
6	AR_21572438_ChIP-Seq_LNCaP_Human	2.73369965
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.64153098
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.50460168
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.44350487
10	VDR_22108803_ChIP-Seq_LS180_Human	2.42677678
11	P300_19829295_ChIP-Seq_ESCs_Human	2.24773804
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.19432719
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.14084757
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.10188146
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.08768176
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.04833228
17	FUS_26573619_Chip-Seq_HEK293_Human	1.92690234
18	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.85603203
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.77117396
20	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.76378164
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.74296538
22	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.70511163
23	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.67084096
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.64770748
25	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.64299543
26	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.59477812
27	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.59477812
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.56157596
29	EWS_26573619_Chip-Seq_HEK293_Human	1.54883720
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.53195602
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.51464568
32	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.49209671
33	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.47292462
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.46978580
35	TCF4_23295773_ChIP-Seq_U87_Human	1.44444633
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.43050432
37	STAT3_23295773_ChIP-Seq_U87_Human	1.42526871
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.41939977
39	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.41602363
40	AR_25329375_ChIP-Seq_VCAP_Human	1.41442969
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40372743
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.40372743
43	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.38754315
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37074628
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33591748
46	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33591748
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.33293960
48	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.32345478
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.30613661
50	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.29671385
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26985539
52	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.26391391
53	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.25769998
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.25769998
55	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.24970480
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.24958611
57	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.23902247
58	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.23424443
59	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.21844659
60	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21114327
61	BCAT_22108803_ChIP-Seq_LS180_Human	1.20368011
62	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.19448282
63	NCOR_22424771_ChIP-Seq_293T_Human	1.18418544
64	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.17771061
65	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.17178430
66	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.16205178
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.14199227
68	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.13144292
69	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12138967
70	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.11469489
71	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.10453545
72	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09471035
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.08776819
74	MYC_19829295_ChIP-Seq_ESCs_Human	1.08448490
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.07775533
76	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05908685
77	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.05511600
78	RUNX2_22187159_ChIP-Seq_PCA_Human	1.04851992
79	MYC_18940864_ChIP-ChIP_HL60_Human	1.04294293
80	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.04158610
81	REST_21632747_ChIP-Seq_MESCs_Mouse	1.03743523
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.03340945
83	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01912189
84	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.01359333
85	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.01191974
86	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00054353
87	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99497150
88	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.99263843
89	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.97679167
90	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.97512930
91	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.96965170
92	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.96423841
93	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.95354188
94	RXR_22108803_ChIP-Seq_LS180_Human	0.95291845
95	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.94935571
96	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.94621658
97	CDX2_22108803_ChIP-Seq_LS180_Human	0.93520986
98	TP53_16413492_ChIP-PET_HCT116_Human	0.92990919
99	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.92712812
100	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.92406288

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	5.62597611
2	MP0002837_dystrophic_cardiac_calcinosis	5.59581488
3	MP0003136_yellow_coat_color	4.78276416
4	MP0002653_abnormal_ependyma_morphology	4.22645314
5	MP0003646_muscle_fatigue	3.12039383
6	MP0000569_abnormal_digit_pigmentation	3.01795056
7	MP0002938_white_spotting	2.93999591
8	MP0001984_abnormal_olfaction	2.87742564
9	MP0005075_abnormal_melanosome_morpholog	2.76290615
10	MP0003950_abnormal_plasma_membrane	2.46044869
11	MP0002138_abnormal_hepatobiliary_system	2.35730323
12	MP0004147_increased_porphyrin_level	2.26524519
13	MP0005220_abnormal_exocrine_pancreas	2.16678610
14	MP0002095_abnormal_skin_pigmentation	2.15926226
15	MP0005174_abnormal_tail_pigmentation	2.14549583
16	MP0003045_fibrosis	2.11135198
17	MP0000015_abnormal_ear_pigmentation	2.09335126
18	MP0005551_abnormal_eye_electrophysiolog	2.02414910
19	MP0008872_abnormal_physiological_respon	2.01929466
20	MP0003890_abnormal_embryonic-extraembry	1.91155310
21	MP0002638_abnormal_pupillary_reflex	1.86673062
22	MP0005646_abnormal_pituitary_gland	1.79038143
23	MP0005084_abnormal_gallbladder_morpholo	1.77219362
24	MP0002102_abnormal_ear_morphology	1.73760767
25	MP0003195_calcinosis	1.69251723
26	MP0008875_abnormal_xenobiotic_pharmacok	1.67910649
27	MP0001968_abnormal_touch/_nociception	1.58472439
28	MP0001986_abnormal_taste_sensitivity	1.53076812
29	MP0001501_abnormal_sleep_pattern	1.50378183
30	MP0002928_abnormal_bile_duct	1.50160733
31	MP0001486_abnormal_startle_reflex	1.44548064
32	MP0004133_heterotaxia	1.42830944
33	MP0005410_abnormal_fertilization	1.40484520
34	MP0004381_abnormal_hair_follicle	1.39377551
35	MP0005085_abnormal_gallbladder_physiolo	1.38699344
36	MP0002160_abnormal_reproductive_system	1.33678788
37	MP0002272_abnormal_nervous_system	1.31978725
38	MP0002876_abnormal_thyroid_physiology	1.31817373
39	MP0003880_abnormal_central_pattern	1.28318311
40	MP0005670_abnormal_white_adipose	1.28116249
41	MP0009745_abnormal_behavioral_response	1.24656803
42	MP0000427_abnormal_hair_cycle	1.24341619
43	MP0005253_abnormal_eye_physiology	1.23154301
44	MP0009046_muscle_twitch	1.21223953
45	MP0002139_abnormal_hepatobiliary_system	1.18843789
46	MP0001661_extended_life_span	1.18197279
47	MP0004142_abnormal_muscle_tone	1.12792132
48	MP0001529_abnormal_vocalization	1.09410646
49	MP0001664_abnormal_digestion	1.09310096
50	MP0006292_abnormal_olfactory_placode	1.08845597
51	MP0002075_abnormal_coat/hair_pigmentati	1.07456098
52	MP0003137_abnormal_impulse_conducting	1.07053605
53	MP0003868_abnormal_feces_composition	1.05816496
54	MP0003806_abnormal_nucleotide_metabolis	1.04587701
55	MP0005365_abnormal_bile_salt	1.03797197
56	MP0001324_abnormal_eye_pigmentation	1.03506854
57	MP0000372_irregular_coat_pigmentation	1.00547576
58	MP0005448_abnormal_energy_balance	0.99492193
59	MP0003879_abnormal_hair_cell	0.99421460
60	MP0004043_abnormal_pH_regulation	0.98830274
61	MP0003011_delayed_dark_adaptation	0.97920409
62	MP0002736_abnormal_nociception_after	0.97753852
63	MP0004885_abnormal_endolymph	0.96895745
64	MP0005389_reproductive_system_phenotype	0.95668598
65	MP0004130_abnormal_muscle_cell	0.95479895
66	MP0005645_abnormal_hypothalamus_physiol	0.94761407
67	MP0004145_abnormal_muscle_electrophysio	0.90641300
68	MP0006072_abnormal_retinal_apoptosis	0.90305165
69	MP0002572_abnormal_emotion/affect_behav	0.89886375
70	MP0002168_other_aberrant_phenotype	0.87505925
71	MP0003698_abnormal_male_reproductive	0.86003375
72	MP0005499_abnormal_olfactory_system	0.85692491
73	MP0005394_taste/olfaction_phenotype	0.85692491
74	MP0001970_abnormal_pain_threshold	0.84554849
75	MP0002064_seizures	0.84454471
76	MP0000631_abnormal_neuroendocrine_gland	0.84340719
77	MP0002733_abnormal_thermal_nociception	0.81831021
78	MP0005167_abnormal_blood-brain_barrier	0.80573637
79	MP0002735_abnormal_chemical_nociception	0.78694119
80	MP0000371_diluted_coat_color	0.78552496
81	MP0000026_abnormal_inner_ear	0.76821404
82	MP0008058_abnormal_DNA_repair	0.76515390
83	MP0002751_abnormal_autonomic_nervous	0.74277533
84	MP0002067_abnormal_sensory_capabilities	0.73803888
85	MP0001963_abnormal_hearing_physiology	0.72960981
86	MP0002557_abnormal_social/conspecific_i	0.72662484
87	MP0002229_neurodegeneration	0.69804211
88	MP0003635_abnormal_synaptic_transmissio	0.68787978
89	MP0005195_abnormal_posterior_eye	0.68544538
90	MP0000749_muscle_degeneration	0.68446488
91	MP0004233_abnormal_muscle_weight	0.67938430
92	MP0001905_abnormal_dopamine_level	0.67369538
93	MP0006054_spinal_hemorrhage	0.67214854
94	MP0000778_abnormal_nervous_system	0.64676265
95	MP0006276_abnormal_autonomic_nervous	0.63917563
96	MP0003252_abnormal_bile_duct	0.63093467
97	MP0005647_abnormal_sex_gland	0.62638290
98	MP0003119_abnormal_digestive_system	0.61907724
99	MP0001929_abnormal_gametogenesis	0.61808228
100	MP0002063_abnormal_learning/memory/cond	0.61514998

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	4.76068155
2	Type II lissencephaly (HP:0007260)	4.64174682
3	Pancreatic cysts (HP:0001737)	4.58135011
4	Focal motor seizures (HP:0011153)	4.34917738
5	Amelogenesis imperfecta (HP:0000705)	4.31596230
6	Abnormality of the renal cortex (HP:0011035)	3.97644667
7	Progressive inability to walk (HP:0002505)	3.83084296
8	Cerebellar dysplasia (HP:0007033)	3.62207613
9	Abnormality of the renal medulla (HP:0100957)	3.57234108
10	Congenital stationary night blindness (HP:0007642)	3.46252480
11	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.42914586
12	Absent/shortened dynein arms (HP:0200106)	3.42914586
13	Inability to walk (HP:0002540)	3.27706440
14	Abnormal biliary tract physiology (HP:0012439)	3.25766466
15	Bile duct proliferation (HP:0001408)	3.25766466
16	Nephronophthisis (HP:0000090)	3.25450875
17	Tubulointerstitial nephritis (HP:0001970)	3.25066513
18	True hermaphroditism (HP:0010459)	3.10926476
19	Tubular atrophy (HP:0000092)	3.01404332
20	Abolished electroretinogram (ERG) (HP:0000550)	3.01297530
21	Abnormal ciliary motility (HP:0012262)	2.94000063
22	Ulnar claw (HP:0001178)	2.91806332
23	Cystic liver disease (HP:0006706)	2.85845453
24	Renal cortical cysts (HP:0000803)	2.85223518
25	Abnormal respiratory motile cilium morphology (HP:0005938)	2.81411212
26	Abnormal respiratory epithelium morphology (HP:0012253)	2.81411212
27	Pendular nystagmus (HP:0012043)	2.79098815
28	Hyperalaninemia (HP:0003348)	2.78578755
29	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.78578755
30	Abnormality of alanine metabolism (HP:0010916)	2.78578755
31	Medial flaring of the eyebrow (HP:0010747)	2.74378320
32	Retinal dysplasia (HP:0007973)	2.73526318
33	Enlarged kidneys (HP:0000105)	2.71505992
34	Colon cancer (HP:0003003)	2.70428672
35	Rectal prolapse (HP:0002035)	2.63180247
36	Acanthocytosis (HP:0001927)	2.59105617
37	Tubulointerstitial abnormality (HP:0001969)	2.54441260
38	Abnormality of macular pigmentation (HP:0008002)	2.53156417
39	Abnormal rod and cone electroretinograms (HP:0008323)	2.52963216
40	Parakeratosis (HP:0001036)	2.48841327
41	Optic nerve hypoplasia (HP:0000609)	2.47420197
42	Polydipsia (HP:0001959)	2.47218084
43	Abnormal drinking behavior (HP:0030082)	2.47218084
44	Dialeptic seizures (HP:0011146)	2.46983539
45	Widely spaced teeth (HP:0000687)	2.46184675
46	Albinism (HP:0001022)	2.45924717
47	Congenital hepatic fibrosis (HP:0002612)	2.44366183
48	Volvulus (HP:0002580)	2.37670599
49	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.37328544
50	Attenuation of retinal blood vessels (HP:0007843)	2.36113438
51	Gait imbalance (HP:0002141)	2.32414755
52	Congenital primary aphakia (HP:0007707)	2.31326288
53	Molar tooth sign on MRI (HP:0002419)	2.30826811
54	Abnormality of midbrain morphology (HP:0002418)	2.30826811
55	Hyperkalemia (HP:0002153)	2.28899096
56	Abnormal respiratory motile cilium physiology (HP:0012261)	2.28806795
57	Dyschromatopsia (HP:0007641)	2.26362944
58	Aplastic anemia (HP:0001915)	2.25964812
59	Type I transferrin isoform profile (HP:0003642)	2.21599036
60	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.20398470
61	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.18911533
62	Focal seizures (HP:0007359)	2.18654031
63	Lissencephaly (HP:0001339)	2.17498006
64	Genital tract atresia (HP:0001827)	2.17091035
65	3-Methylglutaconic aciduria (HP:0003535)	2.16642764
66	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.15308527
67	Increased corneal curvature (HP:0100692)	2.14895038
68	Keratoconus (HP:0000563)	2.14895038
69	Cone-rod dystrophy (HP:0000548)	2.10075427
70	Increased hepatocellular lipid droplets (HP:0006565)	2.09185203
71	Small hand (HP:0200055)	2.06892502
72	CNS hypomyelination (HP:0003429)	2.05793202
73	Stomach cancer (HP:0012126)	2.02381789
74	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.01871445
75	Potter facies (HP:0002009)	2.01831402
76	Facial shape deformation (HP:0011334)	2.01831402
77	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.00951732
78	Decreased central vision (HP:0007663)	1.98605606
79	Proximal amyotrophy (HP:0007126)	1.98088452
80	Chorioretinal atrophy (HP:0000533)	1.97848675
81	Anencephaly (HP:0002323)	1.96801249
82	Rhinitis (HP:0012384)	1.96753409
83	Nephrogenic diabetes insipidus (HP:0009806)	1.96154745
84	Birth length less than 3rd percentile (HP:0003561)	1.93099972
85	Difficulty walking (HP:0002355)	1.92749694
86	Prostate neoplasm (HP:0100787)	1.92272916
87	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.91749491
88	Polyuria (HP:0000103)	1.90533656
89	Lipid accumulation in hepatocytes (HP:0006561)	1.89770741
90	Hyperventilation (HP:0002883)	1.86329083
91	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.85692163
92	Disproportionate short-trunk short stature (HP:0003521)	1.81950836
93	Macular degeneration (HP:0000608)	1.80582983
94	Absent speech (HP:0001344)	1.80278293
95	Vaginal atresia (HP:0000148)	1.80062126
96	Hyperglycinuria (HP:0003108)	1.79130523
97	Hemiparesis (HP:0001269)	1.78822125
98	Opisthotonus (HP:0002179)	1.78107975
99	Chronic hepatic failure (HP:0100626)	1.77795841
100	Abnormal glycosylation (HP:0012345)	1.77184926

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	6.64531273
2	INSRR	5.10282066
3	FRK	4.92352705
4	STK38L	4.54071745
5	MAP4K2	3.74909251
6	TAOK3	2.99283596
7	PRKD3	2.87514492
8	LATS2	2.64301367
9	ZAK	2.31997175
10	MAP2K2	2.16683095
11	CASK	1.94010080
12	BMPR1B	1.74282045
13	NUAK1	1.50506909
14	NLK	1.48372535
15	STK38	1.47064725
16	ADRBK2	1.35916317
17	MAPK13	1.28554163
18	NTRK3	1.24671373
19	PLK2	1.21942279
20	STK3	1.21714528
21	WNK4	1.18039672
22	EPHA4	1.17799397
23	ACVR1B	1.16689537
24	TNIK	1.15677395
25	STK39	1.14101511
26	GRK1	1.06955127
27	BCKDK	1.06479433
28	AKT3	1.04662314
29	DAPK2	1.03719738
30	PTK2B	0.99790355
31	PAK3	0.98361264
32	PIK3CG	0.95235448
33	PINK1	0.93370583
34	MARK1	0.91459876
35	FER	0.89475678
36	VRK2	0.88441520
37	OXSR1	0.83596826
38	MAP2K1	0.80363562
39	ADRBK1	0.78172253
40	PRKAA2	0.74439373
41	LIMK1	0.73475807
42	CAMKK2	0.71961439
43	WNK3	0.70667307
44	TLK1	0.70436079
45	FGFR2	0.65625719
46	PRKCE	0.64743636
47	PIK3CA	0.63766924
48	TEC	0.63140584
49	CSNK1A1L	0.58511426
50	KIT	0.58119703
51	GRK7	0.55295961
52	ITK	0.54568714
53	PRKG2	0.51478544
54	PHKG1	0.48157584
55	PHKG2	0.48157584
56	TGFBR1	0.48105531
57	RPS6KA5	0.46268819
58	GRK5	0.46151191
59	ERBB3	0.43736046
60	TRIM28	0.43567085
61	PAK6	0.42970521
62	MAP3K2	0.42909625
63	VRK1	0.41983296
64	PRKCI	0.41916475
65	MELK	0.41580333
66	IRAK1	0.41313154
67	IKBKB	0.40626618
68	MAPK7	0.40117585
69	CAMK1D	0.38507618
70	PDPK1	0.36258512
71	MAP3K4	0.35870145
72	RPS6KA4	0.35416057
73	STK11	0.34453506
74	MATK	0.34181203
75	PRKACB	0.34133340
76	DYRK2	0.32746816
77	TNK2	0.32367411
78	PRKACA	0.31822709
79	ATR	0.31509359
80	TXK	0.30800656
81	SYK	0.30410131
82	PLK4	0.29890875
83	NTRK2	0.29202182
84	BCR	0.29046722
85	CSNK1D	0.28713579
86	CAMK2A	0.27217596
87	NEK9	0.27096257
88	PRKCZ	0.27093754
89	CDK3	0.26785154
90	PLK3	0.26734475
91	ABL1	0.25434469
92	RPS6KA6	0.24006184
93	PRKCQ	0.23792807
94	EIF2AK3	0.23668645
95	MAPK3	0.22868751
96	LYN	0.21822695
97	IGF1R	0.21151423
98	BRAF	0.21098742
99	CSNK1A1	0.20958912
100	PRKD1	0.20655333

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	4.07320296
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.39962131
3	Nitrogen metabolism_Homo sapiens_hsa00910	3.05857396
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.99711918
5	Butanoate metabolism_Homo sapiens_hsa00650	2.97136976
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.34001710
7	Taste transduction_Homo sapiens_hsa04742	2.15488109
8	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.14791609
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.12882508
10	Nicotine addiction_Homo sapiens_hsa05033	2.10645695
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.09943793
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.03439097
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.94355171
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.93547119
15	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.83565359
16	Propanoate metabolism_Homo sapiens_hsa00640	1.82309205
17	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.79178048
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.77240479
19	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.75966307
20	One carbon pool by folate_Homo sapiens_hsa00670	1.75955733
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.73232698
22	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.67728814
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.60788335
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.59760325
25	Sphingolipid metabolism_Homo sapiens_hsa00600	1.51888067
26	Fatty acid elongation_Homo sapiens_hsa00062	1.39736593
27	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.38439197
28	Basal transcription factors_Homo sapiens_hsa03022	1.38165439
29	RNA polymerase_Homo sapiens_hsa03020	1.36188317
30	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.35596860
31	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.32251016
32	Ether lipid metabolism_Homo sapiens_hsa00565	1.31247446
33	Peroxisome_Homo sapiens_hsa04146	1.29981245
34	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.22935525
35	Morphine addiction_Homo sapiens_hsa05032	1.21361420
36	Caffeine metabolism_Homo sapiens_hsa00232	1.20414326
37	Fatty acid metabolism_Homo sapiens_hsa01212	1.19022386
38	Homologous recombination_Homo sapiens_hsa03440	1.16000815
39	Fatty acid degradation_Homo sapiens_hsa00071	1.15744844
40	GABAergic synapse_Homo sapiens_hsa04727	1.12977850
41	Collecting duct acid secretion_Homo sapiens_hsa04966	1.10799540
42	ABC transporters_Homo sapiens_hsa02010	1.02126709
43	Olfactory transduction_Homo sapiens_hsa04740	1.01999111
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.01611720
45	Fat digestion and absorption_Homo sapiens_hsa04975	1.01098843
46	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00214931
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.95463236
48	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.94390968
49	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.92771824
50	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.90037875
51	Histidine metabolism_Homo sapiens_hsa00340	0.89941867
52	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.89506734
53	Glutamatergic synapse_Homo sapiens_hsa04724	0.88967607
54	Oxidative phosphorylation_Homo sapiens_hsa00190	0.82719127
55	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.81732262
56	Insulin secretion_Homo sapiens_hsa04911	0.80707903
57	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.79384960
58	Steroid biosynthesis_Homo sapiens_hsa00100	0.79197823
59	Salivary secretion_Homo sapiens_hsa04970	0.76973448
60	Metabolic pathways_Homo sapiens_hsa01100	0.76884857
61	Purine metabolism_Homo sapiens_hsa00230	0.76863419
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.75830797
63	Sulfur relay system_Homo sapiens_hsa04122	0.75686311
64	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.75573914
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.72759751
66	Circadian entrainment_Homo sapiens_hsa04713	0.71959738
67	Arginine biosynthesis_Homo sapiens_hsa00220	0.71617234
68	Retinol metabolism_Homo sapiens_hsa00830	0.67554559
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66808076
70	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.66464479
71	Calcium signaling pathway_Homo sapiens_hsa04020	0.64693696
72	Fanconi anemia pathway_Homo sapiens_hsa03460	0.64179828
73	beta-Alanine metabolism_Homo sapiens_hsa00410	0.63461009
74	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.61752341
75	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.60331778
76	Serotonergic synapse_Homo sapiens_hsa04726	0.59778131
77	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.54368221
78	Long-term depression_Homo sapiens_hsa04730	0.53987990
79	Asthma_Homo sapiens_hsa05310	0.53606226
80	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.52683909
81	Protein export_Homo sapiens_hsa03060	0.49330150
82	Folate biosynthesis_Homo sapiens_hsa00790	0.48821223
83	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.48081050
84	RNA degradation_Homo sapiens_hsa03018	0.44588498
85	Nucleotide excision repair_Homo sapiens_hsa03420	0.40719857
86	Huntingtons disease_Homo sapiens_hsa05016	0.39858910
87	Glutathione metabolism_Homo sapiens_hsa00480	0.38835359
88	Parkinsons disease_Homo sapiens_hsa05012	0.37933631
89	Pyruvate metabolism_Homo sapiens_hsa00620	0.36688631
90	Circadian rhythm_Homo sapiens_hsa04710	0.34761905
91	Bile secretion_Homo sapiens_hsa04976	0.34756013
92	Tyrosine metabolism_Homo sapiens_hsa00350	0.32899293
93	Non-homologous end-joining_Homo sapiens_hsa03450	0.30475243
94	Cocaine addiction_Homo sapiens_hsa05030	0.30101067
95	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.28683609
96	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.28041919
97	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.26020446
98	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.25174956
99	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.25098507
100	cAMP signaling pathway_Homo sapiens_hsa04024	0.24940829

MAP1LC3BP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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