MAP1LC3C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-fucose catabolic process (GO:0042355)5.38271265
2fucose catabolic process (GO:0019317)5.38271265
3L-fucose metabolic process (GO:0042354)5.38271265
4behavioral response to nicotine (GO:0035095)4.74182911
5protein neddylation (GO:0045116)4.42440868
6protein polyglutamylation (GO:0018095)4.14675330
7platelet dense granule organization (GO:0060155)3.99706632
8parturition (GO:0007567)3.98278676
9DNA deamination (GO:0045006)3.90032652
10kynurenine metabolic process (GO:0070189)3.74924294
11negative regulation of telomere maintenance (GO:0032205)3.55976284
12cornea development in camera-type eye (GO:0061303)3.54050825
13preassembly of GPI anchor in ER membrane (GO:0016254)3.52476348
14indolalkylamine metabolic process (GO:0006586)3.51449372
15indole-containing compound catabolic process (GO:0042436)3.50799629
16indolalkylamine catabolic process (GO:0046218)3.50799629
17tryptophan catabolic process (GO:0006569)3.50799629
18tryptophan metabolic process (GO:0006568)3.47282476
19protein complex biogenesis (GO:0070271)3.33049820
20response to pheromone (GO:0019236)3.32002013
21detection of light stimulus involved in visual perception (GO:0050908)3.31445359
22detection of light stimulus involved in sensory perception (GO:0050962)3.31445359
23negative regulation of mast cell activation (GO:0033004)3.25274156
24respiratory chain complex IV assembly (GO:0008535)3.20718033
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19092669
26mitochondrial respiratory chain complex I assembly (GO:0032981)3.19092669
27NADH dehydrogenase complex assembly (GO:0010257)3.19092669
28regulation of cilium movement (GO:0003352)3.16624822
29protein-cofactor linkage (GO:0018065)3.15241558
30regulation of action potential (GO:0098900)3.15014554
31cellular ketone body metabolic process (GO:0046950)3.10340889
32piRNA metabolic process (GO:0034587)3.09832652
33inositol phosphate catabolic process (GO:0071545)3.08068784
34detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.05507664
35epithelial cilium movement (GO:0003351)3.01746096
36water-soluble vitamin biosynthetic process (GO:0042364)3.01725042
37cullin deneddylation (GO:0010388)2.99601139
38mitochondrial respiratory chain complex assembly (GO:0033108)2.98210989
39negative regulation of heart rate (GO:0010459)2.97988912
40protein deneddylation (GO:0000338)2.93655827
41ubiquinone biosynthetic process (GO:0006744)2.93482652
42axoneme assembly (GO:0035082)2.91745600
43regulation of rhodopsin mediated signaling pathway (GO:0022400)2.91731346
44cytochrome complex assembly (GO:0017004)2.89485786
45phosphorylated carbohydrate dephosphorylation (GO:0046838)2.89280651
46inositol phosphate dephosphorylation (GO:0046855)2.89280651
47regulation of hexokinase activity (GO:1903299)2.86233082
48regulation of glucokinase activity (GO:0033131)2.86233082
49ATP synthesis coupled proton transport (GO:0015986)2.84071972
50energy coupled proton transport, down electrochemical gradient (GO:0015985)2.84071972
51positive regulation of prostaglandin secretion (GO:0032308)2.83098740
52rhodopsin mediated signaling pathway (GO:0016056)2.83003539
53negative regulation of synaptic transmission, GABAergic (GO:0032229)2.81743346
54mannosylation (GO:0097502)2.79932127
55ubiquinone metabolic process (GO:0006743)2.79410929
56ketone body metabolic process (GO:1902224)2.79406893
57positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.75643779
58fucosylation (GO:0036065)2.74891096
59somite development (GO:0061053)2.72987254
60glycerophospholipid catabolic process (GO:0046475)2.72660718
61mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.66077615
62polyol catabolic process (GO:0046174)2.63296749
63iron-sulfur cluster assembly (GO:0016226)2.61656930
64metallo-sulfur cluster assembly (GO:0031163)2.61656930
65DNA double-strand break processing (GO:0000729)2.60864784
66fucose metabolic process (GO:0006004)2.60749741
67synaptic transmission, cholinergic (GO:0007271)2.59339923
68protein localization to cilium (GO:0061512)2.59045030
69neuronal action potential propagation (GO:0019227)2.58150166
70pyrimidine nucleobase catabolic process (GO:0006208)2.55168483
71cilium morphogenesis (GO:0060271)2.52878475
72epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.52594162
73negative regulation of cytosolic calcium ion concentration (GO:0051481)2.51515696
74DNA methylation involved in gamete generation (GO:0043046)2.50010465
75phenylpropanoid metabolic process (GO:0009698)2.49916165
76indole-containing compound metabolic process (GO:0042430)2.49874395
77tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.49754368
78RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.49754368
79GPI anchor metabolic process (GO:0006505)2.48570185
80proline transport (GO:0015824)2.48135957
81nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.46837869
82RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.46444020
83amine catabolic process (GO:0009310)2.46188140
84cellular biogenic amine catabolic process (GO:0042402)2.46188140
85retinal cone cell development (GO:0046549)2.44879589
86negative regulation of transcription regulatory region DNA binding (GO:2000678)2.44732433
87reflex (GO:0060004)2.43749259
88thalamus development (GO:0021794)2.43111825
89neural tube formation (GO:0001841)2.40977851
90regulation of mesoderm development (GO:2000380)2.40813687
91positive regulation of guanylate cyclase activity (GO:0031284)2.40639110
92arginine metabolic process (GO:0006525)2.38084525
93positive regulation of oligodendrocyte differentiation (GO:0048714)2.35486891
94benzene-containing compound metabolic process (GO:0042537)2.35185017
95S-adenosylmethionine metabolic process (GO:0046500)2.35057192
96positive regulation of action potential (GO:0045760)2.34973013
97transmission of nerve impulse (GO:0019226)2.33333344
98nonmotile primary cilium assembly (GO:0035058)2.33258161
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.33087988
100positive regulation of fatty acid transport (GO:2000193)2.31769124

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.01046599
2VDR_22108803_ChIP-Seq_LS180_Human3.10670359
3IGF1R_20145208_ChIP-Seq_DFB_Human2.73806309
4GBX2_23144817_ChIP-Seq_PC3_Human2.64372498
5EZH2_22144423_ChIP-Seq_EOC_Human2.64091684
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.62785115
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.55436849
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.35773142
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27031617
10EWS_26573619_Chip-Seq_HEK293_Human2.26908936
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.22476908
12P300_19829295_ChIP-Seq_ESCs_Human2.16559748
13TAF15_26573619_Chip-Seq_HEK293_Human2.09083236
14* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08920424
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.08708148
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06486947
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.01793093
18IRF1_19129219_ChIP-ChIP_H3396_Human1.99969076
19FUS_26573619_Chip-Seq_HEK293_Human1.96218560
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88954054
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83032261
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77597987
23ER_23166858_ChIP-Seq_MCF-7_Human1.75266420
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.64103383
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63739450
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62599942
27TP53_22573176_ChIP-Seq_HFKS_Human1.60515585
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.60421794
29* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56794864
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56487551
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55531036
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53846423
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53172782
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52252143
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51675292
36SOX2_19829295_ChIP-Seq_ESCs_Human1.49187493
37NANOG_19829295_ChIP-Seq_ESCs_Human1.49187493
38GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.46723766
39SMAD4_21799915_ChIP-Seq_A2780_Human1.43665968
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.43663514
41CBP_20019798_ChIP-Seq_JUKART_Human1.43456097
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43456097
43MYC_18940864_ChIP-ChIP_HL60_Human1.40630883
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39879729
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.39322962
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39322962
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.37235216
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.33130234
49ETV2_25802403_ChIP-Seq_MESCs_Mouse1.31096415
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30604636
51* AR_25329375_ChIP-Seq_VCAP_Human1.30408484
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30264753
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.29503323
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29458342
55BCAT_22108803_ChIP-Seq_LS180_Human1.29336050
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29033201
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.27620107
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26970961
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25779702
60TCF4_22108803_ChIP-Seq_LS180_Human1.25764675
61AR_20517297_ChIP-Seq_VCAP_Human1.25000141
62* STAT3_23295773_ChIP-Seq_U87_Human1.24967686
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24547923
64RNF2_27304074_Chip-Seq_NSC_Mouse1.23181975
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23021537
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23021537
67TCF4_23295773_ChIP-Seq_U87_Human1.20937594
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20832355
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.20777671
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19692925
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19293971
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.17911946
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16856732
74ELK1_19687146_ChIP-ChIP_HELA_Human1.16111298
75REST_21632747_ChIP-Seq_MESCs_Mouse1.15518976
76CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14399345
77VDR_23849224_ChIP-Seq_CD4+_Human1.13593358
78P53_22387025_ChIP-Seq_ESCs_Mouse1.13571307
79FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13347416
80CRX_20693478_ChIP-Seq_RETINA_Mouse1.12454084
81NCOR_22424771_ChIP-Seq_293T_Human1.11761030
82HOXB7_26014856_ChIP-Seq_BT474_Human1.10200396
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10146538
84RUNX2_22187159_ChIP-Seq_PCA_Human1.09497868
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09359206
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.09121403
87SRF_21415370_ChIP-Seq_HL-1_Mouse1.09092347
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.08576762
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05795404
90HTT_18923047_ChIP-ChIP_STHdh_Human1.05690088
91STAT3_18555785_Chip-Seq_ESCs_Mouse1.03625249
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02529103
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.02458774
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02068813
95SMAD4_21741376_ChIP-Seq_EPCs_Human1.01840272
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01164659
97* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01006076
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00003344
99JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.99805670
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99431637

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.17315753
2MP0005551_abnormal_eye_electrophysiolog2.71458105
3MP0000569_abnormal_digit_pigmentation2.67226289
4MP0008877_abnormal_DNA_methylation2.61904621
5MP0001968_abnormal_touch/_nociception2.56122067
6MP0003011_delayed_dark_adaptation2.54340488
7MP0006072_abnormal_retinal_apoptosis2.42353763
8MP0002102_abnormal_ear_morphology2.39927465
9MP0002837_dystrophic_cardiac_calcinosis2.29644340
10MP0002653_abnormal_ependyma_morphology2.26010583
11MP0002736_abnormal_nociception_after2.17133819
12MP0002876_abnormal_thyroid_physiology2.13972062
13MP0001529_abnormal_vocalization2.10974725
14MP0003880_abnormal_central_pattern2.06952698
15MP0006292_abnormal_olfactory_placode2.06946078
16MP0004142_abnormal_muscle_tone2.02598905
17MP0001986_abnormal_taste_sensitivity2.00890297
18MP0005253_abnormal_eye_physiology1.94494360
19MP0005646_abnormal_pituitary_gland1.88383380
20MP0008875_abnormal_xenobiotic_pharmacok1.81011206
21MP0004147_increased_porphyrin_level1.78915089
22MP0003646_muscle_fatigue1.76349480
23MP0009046_muscle_twitch1.73838443
24MP0003136_yellow_coat_color1.71009051
25MP0008872_abnormal_physiological_respon1.69332995
26MP0005645_abnormal_hypothalamus_physiol1.66727444
27MP0002938_white_spotting1.63755247
28MP0002272_abnormal_nervous_system1.61266580
29MP0004133_heterotaxia1.60516704
30MP0005377_hearing/vestibular/ear_phenot1.60079324
31MP0003878_abnormal_ear_physiology1.60079324
32MP0001486_abnormal_startle_reflex1.56176775
33MP0009745_abnormal_behavioral_response1.54309907
34MP0000372_irregular_coat_pigmentation1.51948664
35MP0004885_abnormal_endolymph1.51216748
36MP0006276_abnormal_autonomic_nervous1.49745677
37MP0005084_abnormal_gallbladder_morpholo1.44775444
38MP0003718_maternal_effect1.44664871
39MP0000427_abnormal_hair_cycle1.43169622
40MP0003787_abnormal_imprinting1.42087285
41MP0001984_abnormal_olfaction1.39157919
42MP0008775_abnormal_heart_ventricle1.37393748
43MP0001485_abnormal_pinna_reflex1.34465861
44MP0005167_abnormal_blood-brain_barrier1.34119072
45MP0001501_abnormal_sleep_pattern1.32591611
46MP0005075_abnormal_melanosome_morpholog1.32589460
47MP0001905_abnormal_dopamine_level1.31753222
48MP0002138_abnormal_hepatobiliary_system1.31076863
49MP0004043_abnormal_pH_regulation1.30639634
50MP0005174_abnormal_tail_pigmentation1.29825628
51MP0002733_abnormal_thermal_nociception1.28705271
52MP0003122_maternal_imprinting1.23853190
53MP0002572_abnormal_emotion/affect_behav1.23444254
54MP0002751_abnormal_autonomic_nervous1.22142444
55MP0008789_abnormal_olfactory_epithelium1.21781918
56MP0004145_abnormal_muscle_electrophysio1.20915142
57MP0002557_abnormal_social/conspecific_i1.19563556
58MP0002638_abnormal_pupillary_reflex1.17719599
59MP0005423_abnormal_somatic_nervous1.17587660
60MP0001970_abnormal_pain_threshold1.16520913
61MP0000631_abnormal_neuroendocrine_gland1.12746843
62MP0005171_absent_coat_pigmentation1.12081869
63MP0002735_abnormal_chemical_nociception1.09772521
64MP0002067_abnormal_sensory_capabilities1.08415794
65MP0006054_spinal_hemorrhage1.07252185
66MP0002064_seizures1.02793233
67MP0005386_behavior/neurological_phenoty1.02283210
68MP0004924_abnormal_behavior1.02283210
69MP0002184_abnormal_innervation1.01821064
70MP0002752_abnormal_somatic_nervous1.01537577
71MP0005195_abnormal_posterior_eye1.00905747
72MP0003186_abnormal_redox_activity0.99070507
73MP0008058_abnormal_DNA_repair0.98832859
74MP0000026_abnormal_inner_ear0.97177968
75MP0003121_genomic_imprinting0.96844710
76MP0001324_abnormal_eye_pigmentation0.96773431
77MP0010386_abnormal_urinary_bladder0.95077214
78MP0000647_abnormal_sebaceous_gland0.95045053
79MP0002229_neurodegeneration0.94707963
80MP0002095_abnormal_skin_pigmentation0.94176218
81MP0004215_abnormal_myocardial_fiber0.93300258
82MP0002822_catalepsy0.91431641
83MP0003119_abnormal_digestive_system0.91392065
84MP0004742_abnormal_vestibular_system0.89848341
85MP0003567_abnormal_fetal_cardiomyocyte0.88985371
86MP0002254_reproductive_system_inflammat0.88506801
87MP0004782_abnormal_surfactant_physiolog0.88437141
88MP0001293_anophthalmia0.88427139
89MP0002909_abnormal_adrenal_gland0.88393832
90MP0003635_abnormal_synaptic_transmissio0.87466588
91MP0002163_abnormal_gland_morphology0.87412684
92MP0005379_endocrine/exocrine_gland_phen0.86235618
93MP0002928_abnormal_bile_duct0.85735641
94MP0003937_abnormal_limbs/digits/tail_de0.85199527
95MP0005499_abnormal_olfactory_system0.82782787
96MP0005394_taste/olfaction_phenotype0.82782787
97MP0001963_abnormal_hearing_physiology0.81461545
98MP0002063_abnormal_learning/memory/cond0.80551335
99MP0001188_hyperpigmentation0.79823068
100MP0001764_abnormal_homeostasis0.79615102

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of midbrain morphology (HP:0002418)4.29812087
2Molar tooth sign on MRI (HP:0002419)4.29812087
3Congenital stationary night blindness (HP:0007642)4.22088062
4Pancreatic cysts (HP:0001737)4.08608751
5Pancreatic fibrosis (HP:0100732)3.78653934
6True hermaphroditism (HP:0010459)3.64651816
7Nephronophthisis (HP:0000090)3.29760433
8Type II lissencephaly (HP:0007260)3.19593741
9Abolished electroretinogram (ERG) (HP:0000550)3.00031839
10Abnormality of the renal cortex (HP:0011035)2.83919990
11Abnormality of the renal medulla (HP:0100957)2.79281348
12Disproportionate short-trunk short stature (HP:0003521)2.77482173
13Polydipsia (HP:0001959)2.70732905
14Abnormal drinking behavior (HP:0030082)2.70732905
15Rib fusion (HP:0000902)2.68940164
16Medial flaring of the eyebrow (HP:0010747)2.68701986
17Colon cancer (HP:0003003)2.64360588
18Tubular atrophy (HP:0000092)2.60685059
19Methylmalonic acidemia (HP:0002912)2.60244530
20Increased CSF lactate (HP:0002490)2.60048068
21Sclerocornea (HP:0000647)2.59408810
223-Methylglutaconic aciduria (HP:0003535)2.57735285
23Attenuation of retinal blood vessels (HP:0007843)2.57715817
24Acute necrotizing encephalopathy (HP:0006965)2.55537753
25Hepatocellular necrosis (HP:0001404)2.53815831
26Mitochondrial inheritance (HP:0001427)2.51331050
27Abnormal rod and cone electroretinograms (HP:0008323)2.50878966
28Hypomagnesemia (HP:0002917)2.47786791
29Type 2 muscle fiber atrophy (HP:0003554)2.47181211
30Keratoconus (HP:0000563)2.45386122
31Increased corneal curvature (HP:0100692)2.45386122
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.44803235
33Abnormality of alanine metabolism (HP:0010916)2.44803235
34Hyperalaninemia (HP:0003348)2.44803235
35Retinal dysplasia (HP:0007973)2.41629543
36Hepatic necrosis (HP:0002605)2.40647904
37Cystic liver disease (HP:0006706)2.33828017
38Lissencephaly (HP:0001339)2.30023210
39Renal cortical cysts (HP:0000803)2.30019746
40Decreased electroretinogram (ERG) amplitude (HP:0000654)2.28881078
41Pendular nystagmus (HP:0012043)2.28754982
42Methylmalonic aciduria (HP:0012120)2.28536502
43Chronic hepatic failure (HP:0100626)2.28484093
44Polyuria (HP:0000103)2.25887770
45Congenital, generalized hypertrichosis (HP:0004540)2.24244868
46Abnormal mitochondria in muscle tissue (HP:0008316)2.24199257
47Progressive macrocephaly (HP:0004481)2.23375783
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.22789880
49Hyperglycinuria (HP:0003108)2.21233212
50Decreased central vision (HP:0007663)2.16807709
51Stomach cancer (HP:0012126)2.16059680
52Acute encephalopathy (HP:0006846)2.15350987
53Thyroid-stimulating hormone excess (HP:0002925)2.14473744
54Chorioretinal atrophy (HP:0000533)2.13214328
55Inability to walk (HP:0002540)2.12136992
56Gaze-evoked nystagmus (HP:0000640)2.11554041
57Polyphagia (HP:0002591)2.11530792
58Pachygyria (HP:0001302)2.08624667
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.08162754
60Hypothermia (HP:0002045)2.07815673
61Absent rod-and cone-mediated responses on ERG (HP:0007688)2.04835913
62Tachypnea (HP:0002789)2.03353712
63Gait imbalance (HP:0002141)2.02873040
64Optic disc pallor (HP:0000543)2.01918960
65Anencephaly (HP:0002323)2.00265978
66Progressive inability to walk (HP:0002505)2.00179431
67Symphalangism affecting the phalanges of the hand (HP:0009773)1.99289405
68Aplasia/Hypoplasia of the tibia (HP:0005772)1.98951941
69Abnormal biliary tract physiology (HP:0012439)1.98358978
70Bile duct proliferation (HP:0001408)1.98358978
71Congenital primary aphakia (HP:0007707)1.97515448
72Severe muscular hypotonia (HP:0006829)1.97364064
73Abnormality of the labia minora (HP:0012880)1.96743324
74Bifid tongue (HP:0010297)1.95743342
75Broad-based gait (HP:0002136)1.93558073
76Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.93166673
77Increased serum lactate (HP:0002151)1.92246783
78Myokymia (HP:0002411)1.90949944
79Optic nerve hypoplasia (HP:0000609)1.89948514
80Hyperventilation (HP:0002883)1.89565112
81Aplasia/Hypoplasia of the spleen (HP:0010451)1.89073207
82Abnormality of the phalanges of the 5th finger (HP:0004213)1.86502374
83Hypoplasia of the fovea (HP:0007750)1.86118773
84Aplasia/Hypoplasia of the fovea (HP:0008060)1.86118773
85Abnormality of serine family amino acid metabolism (HP:0010894)1.85727710
86Abnormality of glycine metabolism (HP:0010895)1.85727710
87Abnormality of magnesium homeostasis (HP:0004921)1.82806854
88Nephrogenic diabetes insipidus (HP:0009806)1.82285939
89Muscle fiber atrophy (HP:0100295)1.81248052
90Furrowed tongue (HP:0000221)1.80723226
91Decreased circulating renin level (HP:0003351)1.80577503
92Postaxial foot polydactyly (HP:0001830)1.80032445
93Cerebellar dysplasia (HP:0007033)1.79165864
94Thyroiditis (HP:0100646)1.78238907
95Bilateral microphthalmos (HP:0007633)1.76981549
96Abnormality of macular pigmentation (HP:0008002)1.76817992
97Large for gestational age (HP:0001520)1.75961769
98Abnormal urine output (HP:0012590)1.74933898
99Congenital hepatic fibrosis (HP:0002612)1.74777345
100Lipid accumulation in hepatocytes (HP:0006561)1.74587511

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.96954537
2BMPR1B3.01833372
3TRIM282.84309951
4CASK2.77648143
5ADRBK22.75342289
6MAP4K22.67855559
7ZAK2.44788073
8PINK12.40170881
9GRK12.40136130
10WNK32.39980138
11WNK42.39407779
12OXSR12.10277856
13TLK12.09389840
14STK391.99130819
15TAOK31.75620980
16PLK21.71517447
17MAP3K41.65107247
18NUAK11.58571328
19BCR1.56274849
20STK161.54639194
21BCKDK1.50727063
22PIK3CA1.46788405
23TNIK1.40231614
24CDK191.30733709
25TGFBR11.30422556
26ERBB31.28992743
27MAPK131.24829259
28TIE11.22618447
29MAP2K71.22514143
30MARK11.19695086
31PHKG11.18838351
32PHKG21.18838351
33CSNK1G21.18055919
34TXK1.17145511
35PAK31.16483162
36EPHA41.14606264
37LIMK11.14117010
38DYRK21.13984028
39ACVR1B1.13050880
40CSNK1G31.07329360
41MAP3K91.06138083
42MST41.04746838
43MKNK21.03580673
44CSNK1A1L1.02382176
45EIF2AK31.02179973
46DAPK21.01323657
47PRKCE0.99684240
48KIT0.95066845
49STK38L0.91319552
50CSNK1G10.89056818
51MAPKAPK50.87752748
52PRKCG0.86093754
53PLK30.84505298
54INSRR0.82397019
55MUSK0.81853978
56ADRBK10.81488537
57VRK10.80554645
58MAPKAPK30.80202487
59MKNK10.79555425
60NTRK30.75122282
61ARAF0.72118868
62PLK40.70373003
63NTRK20.67959679
64VRK20.66579918
65PTK2B0.66004851
66SIK30.65602721
67CAMK2A0.62771024
68TSSK60.60271028
69FLT30.60234215
70MAPK150.59202949
71FER0.58934880
72PRKCI0.56635726
73DYRK30.54841501
74MINK10.53334588
75OBSCN0.53169727
76FGFR20.50563577
77CAMKK20.48809830
78RPS6KA50.48325872
79TEC0.47796436
80CSNK1A10.42452871
81PIM20.39918487
82NME10.38549664
83PRKACA0.38143140
84CDK80.36672039
85CSNK1D0.36511277
86CAMK2D0.35888158
87DYRK1A0.35467689
88PRKCQ0.33285805
89PDK20.32927511
90MAP2K60.32187264
91PRKCA0.31042654
92GRK50.29497103
93ABL10.29008197
94MAP3K120.28915823
95PAK60.28146242
96PKN10.28065242
97PRKG10.27592530
98PLK10.27550353
99NLK0.26461171
100FES0.25774909

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.08394087
2Oxidative phosphorylation_Homo sapiens_hsa001902.78438214
3Caffeine metabolism_Homo sapiens_hsa002322.71452932
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.66942542
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.62364761
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45831787
7Parkinsons disease_Homo sapiens_hsa050122.38383839
8Linoleic acid metabolism_Homo sapiens_hsa005912.21528747
9Protein export_Homo sapiens_hsa030602.20198406
10Butanoate metabolism_Homo sapiens_hsa006502.11613921
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.05797677
12Nicotine addiction_Homo sapiens_hsa050332.05684188
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.05066188
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.04113053
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.96713499
16Tryptophan metabolism_Homo sapiens_hsa003801.91609642
17Nitrogen metabolism_Homo sapiens_hsa009101.91093842
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84740388
19Ether lipid metabolism_Homo sapiens_hsa005651.78584872
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.66745232
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.63061156
22Proteasome_Homo sapiens_hsa030501.62146607
23Propanoate metabolism_Homo sapiens_hsa006401.58016832
24Basal transcription factors_Homo sapiens_hsa030221.53094698
25Huntingtons disease_Homo sapiens_hsa050161.49569942
26Cardiac muscle contraction_Homo sapiens_hsa042601.47225556
27Alzheimers disease_Homo sapiens_hsa050101.47085045
28Selenocompound metabolism_Homo sapiens_hsa004501.44511104
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.36771962
30Homologous recombination_Homo sapiens_hsa034401.35325376
31Peroxisome_Homo sapiens_hsa041461.28398884
32Taste transduction_Homo sapiens_hsa047421.27981234
33RNA polymerase_Homo sapiens_hsa030201.26422401
34Fanconi anemia pathway_Homo sapiens_hsa034601.25118953
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23859337
36Morphine addiction_Homo sapiens_hsa050321.22830979
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.20368041
38Asthma_Homo sapiens_hsa053101.19064096
39Steroid biosynthesis_Homo sapiens_hsa001001.17850698
40RNA degradation_Homo sapiens_hsa030181.11197447
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10057840
42Non-homologous end-joining_Homo sapiens_hsa034501.08242583
43Fatty acid elongation_Homo sapiens_hsa000621.07106978
44GABAergic synapse_Homo sapiens_hsa047271.05031736
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04030622
46Arachidonic acid metabolism_Homo sapiens_hsa005901.01446958
47Regulation of autophagy_Homo sapiens_hsa041401.00006104
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.97394783
49Collecting duct acid secretion_Homo sapiens_hsa049660.94609167
50Olfactory transduction_Homo sapiens_hsa047400.93494511
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.91051486
52Chemical carcinogenesis_Homo sapiens_hsa052040.88187166
53One carbon pool by folate_Homo sapiens_hsa006700.85443775
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84905080
55Retinol metabolism_Homo sapiens_hsa008300.84556335
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.83031774
57beta-Alanine metabolism_Homo sapiens_hsa004100.82665136
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81080076
59Serotonergic synapse_Homo sapiens_hsa047260.80033629
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79665122
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77856540
62Sulfur metabolism_Homo sapiens_hsa009200.76344420
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73313503
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72529495
65Metabolic pathways_Homo sapiens_hsa011000.70755557
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69390951
67Sulfur relay system_Homo sapiens_hsa041220.68976495
68Type I diabetes mellitus_Homo sapiens_hsa049400.68789953
69Ovarian steroidogenesis_Homo sapiens_hsa049130.67904365
70Glutamatergic synapse_Homo sapiens_hsa047240.67306740
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.66845114
72ABC transporters_Homo sapiens_hsa020100.66496981
73Fat digestion and absorption_Homo sapiens_hsa049750.66386697
74Insulin secretion_Homo sapiens_hsa049110.65980922
75Purine metabolism_Homo sapiens_hsa002300.65332771
76Circadian entrainment_Homo sapiens_hsa047130.62612682
77Fatty acid degradation_Homo sapiens_hsa000710.62537958
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59271464
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56151155
80Allograft rejection_Homo sapiens_hsa053300.55024258
81Histidine metabolism_Homo sapiens_hsa003400.54656736
82Salivary secretion_Homo sapiens_hsa049700.53995751
83Autoimmune thyroid disease_Homo sapiens_hsa053200.52668970
84Graft-versus-host disease_Homo sapiens_hsa053320.52327230
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52200180
86Pyruvate metabolism_Homo sapiens_hsa006200.51060140
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44710299
88Arginine and proline metabolism_Homo sapiens_hsa003300.43928280
89Primary immunodeficiency_Homo sapiens_hsa053400.43607696
90Pyrimidine metabolism_Homo sapiens_hsa002400.42419919
91Long-term depression_Homo sapiens_hsa047300.40132770
92Rheumatoid arthritis_Homo sapiens_hsa053230.40125986
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38518263
94Mineral absorption_Homo sapiens_hsa049780.38043410
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37879874
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36158785
97Dopaminergic synapse_Homo sapiens_hsa047280.33164705
98Glutathione metabolism_Homo sapiens_hsa004800.32189455
99Nucleotide excision repair_Homo sapiens_hsa034200.31395281
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30973726

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