MAP1S

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.24553559
2DNA unwinding involved in DNA replication (GO:0006268)4.88325290
3protein localization to kinetochore (GO:0034501)4.39759261
4peptidyl-arginine omega-N-methylation (GO:0035247)4.20230767
5barbed-end actin filament capping (GO:0051016)4.19877467
6pre-miRNA processing (GO:0031054)4.10954017
7response to peptidoglycan (GO:0032494)4.10794838
8heterochromatin organization (GO:0070828)4.09817009
9cell-cell junction maintenance (GO:0045217)3.93060301
10histone arginine methylation (GO:0034969)3.83718303
11protein localization to endosome (GO:0036010)3.78930282
12formation of translation preinitiation complex (GO:0001731)3.73632743
13histone H4-K12 acetylation (GO:0043983)3.73233591
14mannose metabolic process (GO:0006013)3.70866565
15regulation of translational fidelity (GO:0006450)3.65339750
16regulation of posttranscriptional gene silencing (GO:0060147)3.63372882
17regulation of gene silencing by miRNA (GO:0060964)3.63372882
18regulation of gene silencing by RNA (GO:0060966)3.63372882
19G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.58774824
20DNA replication initiation (GO:0006270)3.55411784
21regulation of translational termination (GO:0006449)3.52448594
22peptidyl-arginine N-methylation (GO:0035246)3.51657758
23peptidyl-arginine methylation (GO:0018216)3.51657758
24stress fiber assembly (GO:0043149)3.50968092
25protein localization to chromosome, centromeric region (GO:0071459)3.47148806
26DNA strand elongation involved in DNA replication (GO:0006271)3.46529058
27mitotic nuclear envelope disassembly (GO:0007077)3.42805964
28intracellular estrogen receptor signaling pathway (GO:0030520)3.39843709
29adenosine receptor signaling pathway (GO:0001973)3.36942329
30negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.35178931
31mitotic sister chromatid segregation (GO:0000070)3.30653375
32IMP biosynthetic process (GO:0006188)3.27449324
33membrane disassembly (GO:0030397)3.26566960
34nuclear envelope disassembly (GO:0051081)3.26566960
35regulation of leukocyte degranulation (GO:0043300)3.26187530
36DNA strand elongation (GO:0022616)3.25899264
37response to muramyl dipeptide (GO:0032495)3.23894129
38nodal signaling pathway (GO:0038092)3.17530193
39positive regulation by symbiont of host defense response (GO:0052509)3.16568367
40modulation by symbiont of host defense response (GO:0052031)3.16568367
41modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.16568367
42modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.16568367
43positive regulation by organism of defense response of other organism involved in symbiotic interact3.16568367
44modulation by symbiont of host immune response (GO:0052553)3.16568367
45regulation of mast cell degranulation (GO:0043304)3.16440817
46protein kinase C signaling (GO:0070528)3.15270932
47folic acid-containing compound biosynthetic process (GO:0009396)3.15102028
48DNA replication-dependent nucleosome assembly (GO:0006335)3.13613647
49DNA replication-dependent nucleosome organization (GO:0034723)3.13613647
50regulation of early endosome to late endosome transport (GO:2000641)3.12103120
51regulation of myeloid leukocyte mediated immunity (GO:0002886)3.11904142
52DNA duplex unwinding (GO:0032508)3.10975215
53NIK/NF-kappaB signaling (GO:0038061)3.10024144
54regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.09787125
55histone H4-K8 acetylation (GO:0043982)3.09726466
56histone H4-K5 acetylation (GO:0043981)3.09726466
57DNA geometric change (GO:0032392)3.08594036
58ribosome biogenesis (GO:0042254)3.06265203
59regulation of T-helper 2 cell differentiation (GO:0045628)3.04863843
60amino sugar catabolic process (GO:0046348)3.03723522
61regulation of regulated secretory pathway (GO:1903305)2.96896461
62nuclear pore organization (GO:0006999)2.95882977
63mitotic G1 DNA damage checkpoint (GO:0031571)2.95220871
64negative regulation of RNA splicing (GO:0033119)2.90152417
65maturation of SSU-rRNA (GO:0030490)2.89550450
66semaphorin-plexin signaling pathway (GO:0071526)2.88725382
67synaptic vesicle docking involved in exocytosis (GO:0016081)2.87786894
68nuclear pore complex assembly (GO:0051292)2.87426952
69regulation of ARF GTPase activity (GO:0032312)2.87404079
70sister chromatid segregation (GO:0000819)2.86038641
71macrophage activation involved in immune response (GO:0002281)2.84336731
72negative regulation of gene silencing (GO:0060969)2.83485600
73regulation of protein heterodimerization activity (GO:0043497)2.83185218
74telomere maintenance via semi-conservative replication (GO:0032201)2.82014297
75chromatin assembly (GO:0031497)2.81346563
76modulation by symbiont of host cellular process (GO:0044068)2.81329289
77synaptic vesicle exocytosis (GO:0016079)2.80934593
78ribosomal small subunit biogenesis (GO:0042274)2.78989838
79viral transcription (GO:0019083)2.78982663
80modulation by virus of host process (GO:0019054)2.78200418
81negative regulation of telomerase activity (GO:0051974)2.78053049
82activation of MAPKKK activity (GO:0000185)2.77604934
83regulation of NFAT protein import into nucleus (GO:0051532)2.76025077
84pinocytosis (GO:0006907)2.75970196
85positive regulation of protein sumoylation (GO:0033235)2.75349417
86IMP metabolic process (GO:0046040)2.74879518
87negative regulation of histone methylation (GO:0031061)2.74749257
88maternal placenta development (GO:0001893)2.74285728
89cell junction maintenance (GO:0034331)2.74264128
90lipopolysaccharide-mediated signaling pathway (GO:0031663)2.73613433
91pentose-phosphate shunt (GO:0006098)2.73114619
92activation of Rac GTPase activity (GO:0032863)2.72399279
93regulation of mast cell activation involved in immune response (GO:0033006)2.71805816
94regulation of nuclear cell cycle DNA replication (GO:0033262)2.70784544
95ribonucleoprotein complex biogenesis (GO:0022613)2.70040779
96cytoskeletal anchoring at plasma membrane (GO:0007016)2.68978296
97negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.68436607
98translational termination (GO:0006415)2.67419738
99immunoglobulin mediated immune response (GO:0016064)2.66010339
100regulation of chromatin binding (GO:0035561)2.65712161
101regulation of hippo signaling (GO:0035330)2.65201129
102protein retention in ER lumen (GO:0006621)2.65156884
103response to acidic pH (GO:0010447)2.64405823
104nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.63893385
105negative regulation of interleukin-12 production (GO:0032695)2.62920531
106histone H4 deacetylation (GO:0070933)2.62760363
107angiogenesis involved in wound healing (GO:0060055)2.61954586
108negative regulation of granulocyte differentiation (GO:0030853)2.59688015
109apoptotic process involved in morphogenesis (GO:0060561)2.59648661
110negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.59376379
111translational initiation (GO:0006413)2.57787504
112negative regulation of mRNA processing (GO:0050686)2.57635623
113translational elongation (GO:0006414)2.57251509
114DNA replication checkpoint (GO:0000076)2.57215988
115nucleobase biosynthetic process (GO:0046112)2.55903801
116positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.55669765
117nuclear envelope organization (GO:0006998)2.55362783
118T cell apoptotic process (GO:0070231)2.54544368
119DNA deamination (GO:0045006)2.53886831
120protein-DNA complex disassembly (GO:0032986)2.53715355
121nucleosome disassembly (GO:0006337)2.53715355
122signal complex assembly (GO:0007172)2.52137208
123pseudouridine synthesis (GO:0001522)2.52023374
124mitotic G1/S transition checkpoint (GO:0044819)2.52016504
125positive regulation of protein dephosphorylation (GO:0035307)2.51235824
126dosage compensation (GO:0007549)2.50743636
127regulation of defense response to virus by virus (GO:0050690)2.50642286
128protein complex localization (GO:0031503)2.50346134
129negative regulation of myeloid cell apoptotic process (GO:0033033)2.49514397
130glucose catabolic process (GO:0006007)2.47882647
131epithelial cell differentiation involved in prostate gland development (GO:0060742)2.47844336
1323-UTR-mediated mRNA stabilization (GO:0070935)2.46369769
133regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.46185511
134positive regulation of gene expression, epigenetic (GO:0045815)2.45224169
135establishment of integrated proviral latency (GO:0075713)2.45179157
136negative regulation of cell size (GO:0045792)2.44566240
137regulation of superoxide anion generation (GO:0032928)2.44423749
138peptidyl-lysine dimethylation (GO:0018027)2.43865897
139activation of JUN kinase activity (GO:0007257)2.43596114
140regulation of mammary gland epithelial cell proliferation (GO:0033599)2.43292571
141cell migration in hindbrain (GO:0021535)2.43262393
142negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.42413481
143regulation of gene silencing (GO:0060968)2.41965604
144negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.40865605
145histone H4-K16 acetylation (GO:0043984)2.40051918
146positive regulation of SMAD protein import into nucleus (GO:0060391)2.39683173
147negative regulation of myotube differentiation (GO:0010832)2.39409947
148translesion synthesis (GO:0019985)2.38506929
149telomere maintenance via telomere lengthening (GO:0010833)2.38245107
150regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.38190963
151positive regulation of receptor recycling (GO:0001921)2.37498934
152positive regulation of histone deacetylation (GO:0031065)2.36953370
153base-excision repair (GO:0006284)2.36917455
154positive regulation of protein deacetylation (GO:0090312)2.36817900
155negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.36752127
156mitotic chromosome condensation (GO:0007076)2.36629350
157regulation of histone H3-K9 methylation (GO:0051570)2.36325717
158ribosomal small subunit assembly (GO:0000028)2.36246863
159ncRNA 3-end processing (GO:0043628)2.36131627
160cellular response to thyroid hormone stimulus (GO:0097067)2.36090572
161COPI coating of Golgi vesicle (GO:0048205)2.35829035
162Golgi transport vesicle coating (GO:0048200)2.35829035
163UV protection (GO:0009650)2.34829375
164somatic diversification of immune receptors via somatic mutation (GO:0002566)2.34434202
165somatic hypermutation of immunoglobulin genes (GO:0016446)2.34434202
166negative regulation of mRNA metabolic process (GO:1903312)2.34335141
167maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.33725262
168trophectodermal cell differentiation (GO:0001829)2.33679278
169lymph vessel development (GO:0001945)2.33406781
170phagosome maturation (GO:0090382)2.32571140
171positive regulation of regulated secretory pathway (GO:1903307)2.32281002
172chromatin assembly or disassembly (GO:0006333)2.31915780
173positive regulation of Cdc42 GTPase activity (GO:0043089)2.31686543
174amyloid precursor protein catabolic process (GO:0042987)2.31599203
175mRNA splicing, via spliceosome (GO:0000398)2.31231960
176RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.31231960
177positive regulation of leukocyte degranulation (GO:0043302)2.31196564
178pentose metabolic process (GO:0019321)2.30821773
179negative regulation of toll-like receptor signaling pathway (GO:0034122)2.29564011
180adherens junction assembly (GO:0034333)2.29208675
181amino acid import (GO:0043090)2.29063016
182positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.29031221
183germinal center formation (GO:0002467)2.28698798
184positive regulation of mast cell degranulation (GO:0043306)2.28674271
185positive regulation of mast cell activation involved in immune response (GO:0033008)2.28674271
186phosphatidylglycerol biosynthetic process (GO:0006655)2.27858978
187sodium ion export (GO:0071436)2.26975037
188retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.26937585
189positive regulation of synapse maturation (GO:0090129)2.26276344
190retrograde transport, endosome to Golgi (GO:0042147)2.24802381
191positive regulation of myotube differentiation (GO:0010831)2.24736110

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.07525793
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.52188913
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.43917469
4MYC_22102868_ChIP-Seq_BL_Human3.23594394
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.15295151
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.93980409
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.76635913
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55582815
9VDR_21846776_ChIP-Seq_THP-1_Human2.39780285
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.17664157
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.11656296
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.07700561
13ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.05177258
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.01508861
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.00140615
16XRN2_22483619_ChIP-Seq_HELA_Human1.97964914
17KDM2B_26808549_Chip-Seq_K562_Human1.96136327
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.94370767
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.89288576
20SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.87667541
21TET1_21451524_ChIP-Seq_MESCs_Mouse1.80724820
22CIITA_25753668_ChIP-Seq_RAJI_Human1.77191879
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.76613403
24BP1_19119308_ChIP-ChIP_Hs578T_Human1.75217970
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73379105
26TCF7_22412390_ChIP-Seq_EML_Mouse1.71375826
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71050625
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70164049
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.69742990
30* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.67460729
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67301707
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66779177
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65527235
34KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.65506326
35KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.65506326
36KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.65506326
37SA1_27219007_Chip-Seq_ERYTHROID_Human1.63436187
38KDM2B_26808549_Chip-Seq_DND41_Human1.62042178
39KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.61786487
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.59700872
41DNAJC2_21179169_ChIP-ChIP_NT2_Human1.59272173
42* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.59260181
43CTCF_27219007_Chip-Seq_ERYTHROID_Human1.58347949
44CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.58184232
45SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.57894489
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57746018
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57037958
48* LXR_22292898_ChIP-Seq_THP-1_Human1.54787732
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52123719
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51062201
51MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.49385329
52* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48811853
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48731074
54* BCL6_27268052_Chip-Seq_Bcells_Human1.48142814
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.47786876
56SMC4_20622854_ChIP-Seq_HELA_Human1.47489850
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47219012
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46160239
59* BCOR_27268052_Chip-Seq_Bcells_Human1.44034394
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43365595
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.40582118
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39140531
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37798482
64ZNF263_19887448_ChIP-Seq_K562_Human1.35321033
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33318543
66JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33188889
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32714107
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32635460
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32158938
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30826644
71UTX_26944678_Chip-Seq_JUKART_Human1.29696793
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.29562597
73ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.28961564
74MAF_26560356_Chip-Seq_TH1_Human1.27816810
75GABP_19822575_ChIP-Seq_HepG2_Human1.27754221
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27451759
77SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27302374
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.26495992
79CTCF_27219007_Chip-Seq_Bcells_Human1.26283701
80TTF2_22483619_ChIP-Seq_HELA_Human1.26195153
81VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26023684
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.25185135
83ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24969105
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24149158
85CREB1_26743006_Chip-Seq_LNCaP_Human1.23677356
86* ELF1_20517297_ChIP-Seq_JURKAT_Human1.23613636
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.22898942
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22827300
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22725857
90MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21619048
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20904308
92MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20527463
93* TFEB_21752829_ChIP-Seq_HELA_Human1.20415267
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19929443
95STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19567373
96E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18924125
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18217188
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17459083
99BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17345524
100* SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16876158
101PHF8_20622854_ChIP-Seq_HELA_Human1.16440917
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.15416345
103PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14438308
104KDM5A_27292631_Chip-Seq_BREAST_Human1.14217301
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13561256
106CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13282498
107NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.12689374
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11935846
109FOXP3_21729870_ChIP-Seq_TREG_Human1.11835192
110TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11680362
111IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11627461
112GATA1_19941827_ChIP-Seq_MEL_Mouse1.11501668
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10502732
114E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10430244
115RACK7_27058665_Chip-Seq_MCF-7_Human1.09097171
116TP63_17297297_ChIP-ChIP_HaCaT_Human1.09078353
117SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09030055
118TET1_21490601_ChIP-Seq_MESCs_Mouse1.08371432
119GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08055516
120CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07271691
121TP53_22127205_ChIP-Seq_IMR90_Human1.07202046
122* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07101894
123VDR_24763502_ChIP-Seq_THP-1_Human1.06789697
124TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06697672
125NCOR1_26117541_ChIP-Seq_K562_Human1.06375576
126CTCF_26484167_Chip-Seq_Bcells_Mouse1.06185283
127SA1_27219007_Chip-Seq_Bcells_Human1.06165688
128SPI1_23127762_ChIP-Seq_K562_Human1.05816628
129SCL_19346495_ChIP-Seq_HPC-7_Human1.05617219
130ATF3_27146783_Chip-Seq_COLON_Human1.05298359
131TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04984519
132SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04603144
133CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04370191
134MAF_26560356_Chip-Seq_TH2_Human1.03895736
135DCP1A_22483619_ChIP-Seq_HELA_Human1.03685089
136* E2F1_20622854_ChIP-Seq_HELA_Human1.03018217
137KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02434894
138* P68_20966046_ChIP-Seq_HELA_Human1.02415753
139SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02192079
140MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01472392
141PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01396749
142RUNX1_22412390_ChIP-Seq_EML_Mouse1.01263637
143VDR_23849224_ChIP-Seq_CD4+_Human1.00883101
144SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00450782
145RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00372228
146JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.00146371
147TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99837693
148HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99645820
149NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99619317
150OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99211092
151RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99048604
152SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98935654
153NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96616470
154FOXP1_21924763_ChIP-Seq_HESCs_Human0.96267442
155KDM2B_26808549_Chip-Seq_JURKAT_Human0.95869221

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.52583700
2MP0009840_abnormal_foam_cell3.18694503
3MP0008260_abnormal_autophagy3.05081359
4MP0003111_abnormal_nucleus_morphology2.98142070
5MP0003693_abnormal_embryo_hatching2.91601046
6MP0004957_abnormal_blastocyst_morpholog2.89765855
7MP0010352_gastrointestinal_tract_polyps2.83465799
8MP0003077_abnormal_cell_cycle2.56612556
9MP0010094_abnormal_chromosome_stability2.54961229
10MP0002396_abnormal_hematopoietic_system2.52839960
11MP0005451_abnormal_body_composition2.36409869
12MP0008057_abnormal_DNA_replication2.33174284
13MP0003075_altered_response_to2.19725052
14MP0005076_abnormal_cell_differentiation2.17954281
15MP0003329_amyloid_beta_deposits2.16978292
16MP0008007_abnormal_cellular_replicative2.14868351
17MP0010030_abnormal_orbit_morphology2.12073968
18MP0003123_paternal_imprinting2.09273742
19MP0001730_embryonic_growth_arrest2.08243265
20MP0002254_reproductive_system_inflammat2.07960290
21MP0009278_abnormal_bone_marrow2.05787418
22MP0003705_abnormal_hypodermis_morpholog2.03150563
23MP0000350_abnormal_cell_proliferation2.01248987
24MP0004858_abnormal_nervous_system1.90052684
25MP0003191_abnormal_cellular_cholesterol1.89598226
26MP0002653_abnormal_ependyma_morphology1.87275418
27MP0000604_amyloidosis1.84253547
28MP0002419_abnormal_innate_immunity1.81476931
29MP0004808_abnormal_hematopoietic_stem1.81013012
30MP0004133_heterotaxia1.78339738
31MP0001348_abnormal_lacrimal_gland1.77204143
32MP0003283_abnormal_digestive_organ1.69874303
33MP0010307_abnormal_tumor_latency1.66313908
34MP0008932_abnormal_embryonic_tissue1.56582189
35MP0008058_abnormal_DNA_repair1.55831060
36MP0002085_abnormal_embryonic_tissue1.55546196
37MP0003172_abnormal_lysosome_physiology1.54473897
38MP0001672_abnormal_embryogenesis/_devel1.54252202
39MP0005380_embryogenesis_phenotype1.54252202
40MP0002084_abnormal_developmental_patter1.52100635
41MP0001697_abnormal_embryo_size1.48879413
42MP0005025_abnormal_response_to1.48707333
43MP0001849_ear_inflammation1.48073038
44MP0002080_prenatal_lethality1.47712927
45MP0005167_abnormal_blood-brain_barrier1.47217995
46MP0000343_altered_response_to1.44713572
47MP0005464_abnormal_platelet_physiology1.44363814
48MP0001545_abnormal_hematopoietic_system1.44198130
49MP0005397_hematopoietic_system_phenotyp1.44198130
50MP0001533_abnormal_skeleton_physiology1.43798124
51MP0003984_embryonic_growth_retardation1.43102466
52MP0004197_abnormal_fetal_growth/weight/1.43001751
53MP0000490_abnormal_crypts_of1.42412656
54MP0009333_abnormal_splenocyte_physiolog1.41970492
55MP0000703_abnormal_thymus_morphology1.41327267
56MP0002088_abnormal_embryonic_growth/wei1.40920230
57MP0008961_abnormal_basal_metabolism1.39994201
58MP0004859_abnormal_synaptic_plasticity1.37417996
59MP0002998_abnormal_bone_remodeling1.37180204
60MP0002249_abnormal_larynx_morphology1.35986939
61MP0000313_abnormal_cell_death1.35472391
62MP0003121_genomic_imprinting1.35472289
63MP0002086_abnormal_extraembryonic_tissu1.34533643
64MP0003566_abnormal_cell_adhesion1.34506870
65MP0002148_abnormal_hypersensitivity_rea1.34286176
66MP0002398_abnormal_bone_marrow1.32706325
67MP0003634_abnormal_glial_cell1.30290176
68MP0005023_abnormal_wound_healing1.29569364
69MP0003303_peritoneal_inflammation1.27130395
70MP0005623_abnormal_meninges_morphology1.26524766
71MP0000685_abnormal_immune_system1.25616055
72MP0003122_maternal_imprinting1.24055167
73MP0008877_abnormal_DNA_methylation1.23306387
74MP0000733_abnormal_muscle_development1.23246785
75MP0003763_abnormal_thymus_physiology1.22785047
76MP0003119_abnormal_digestive_system1.20023272
77MP0000751_myopathy1.19268127
78MP0002722_abnormal_immune_system1.19228151
79MP0000858_altered_metastatic_potential1.18923151
80MP0003453_abnormal_keratinocyte_physiol1.18851719
81MP0003724_increased_susceptibility_to1.18634166
82MP0003183_abnormal_peptide_metabolism1.18224307
83MP0003690_abnormal_glial_cell1.18177399
84MP0008770_decreased_survivor_rate1.17539244
85MP0004947_skin_inflammation1.16986570
86MP0005670_abnormal_white_adipose1.16977555
87MP0006082_CNS_inflammation1.14076888
88MP0002019_abnormal_tumor_incidence1.13788000
89MP0004233_abnormal_muscle_weight1.12223394
90MP0003828_pulmonary_edema1.10713462
91MP0000689_abnormal_spleen_morphology1.09970502
92MP0002089_abnormal_postnatal_growth/wei1.08540518
93MP0004510_myositis1.08469949
94MP0008874_decreased_physiological_sensi1.07828484
95MP0003091_abnormal_cell_migration1.05752474
96MP0005387_immune_system_phenotype1.05319890
97MP0001790_abnormal_immune_system1.05319890
98MP0005390_skeleton_phenotype1.04097545
99MP0000920_abnormal_myelination1.03748841
100MP0003890_abnormal_embryonic-extraembry1.03595516
101MP0003436_decreased_susceptibility_to1.02141305
102MP0005166_decreased_susceptibility_to1.01983322
103MP0005621_abnormal_cell_physiology0.99671517
104MP0000767_abnormal_smooth_muscle0.99521135
105MP0003279_aneurysm0.99489122
106MP0000681_abnormal_thyroid_gland0.99349159
107MP0000358_abnormal_cell_content/0.98953324
108MP0002429_abnormal_blood_cell0.96191878
109MP0002405_respiratory_system_inflammati0.96020277
110MP0005384_cellular_phenotype0.93642477
111MP0001542_abnormal_bone_strength0.93062109
112MP0002925_abnormal_cardiovascular_devel0.93058836
113MP0003635_abnormal_synaptic_transmissio0.91470801
114MP0001293_anophthalmia0.90688876
115MP0000716_abnormal_immune_system0.89731911
116MP0002877_abnormal_melanocyte_morpholog0.89416940
117MP0010368_abnormal_lymphatic_system0.88388572
118MP0000750_abnormal_muscle_regeneration0.87642490
119MP0000678_abnormal_parathyroid_gland0.87345235
120MP0002822_catalepsy0.85071644
121MP0000428_abnormal_craniofacial_morphol0.83076260
122MP0000747_muscle_weakness0.82722930
123MP0003861_abnormal_nervous_system0.81956032
124MP0001800_abnormal_humoral_immune0.81348025
125MP0000465_gastrointestinal_hemorrhage0.80737353
126MP0005375_adipose_tissue_phenotype0.79961389
127MP0005671_abnormal_response_to0.77662493
128MP0009785_altered_susceptibility_to0.77143725
129MP0005595_abnormal_vascular_smooth0.76963989
130MP0000049_abnormal_middle_ear0.76315134
131MP0002452_abnormal_antigen_presenting0.75797371
132MP0002420_abnormal_adaptive_immunity0.75387754
133MP0002932_abnormal_joint_morphology0.75375302
134MP0001819_abnormal_immune_cell0.75013610
135MP0000003_abnormal_adipose_tissue0.74897897
136MP0003448_altered_tumor_morphology0.74171522
137MP0001915_intracranial_hemorrhage0.73301377
138MP0003879_abnormal_hair_cell0.73244310
139MP0005423_abnormal_somatic_nervous0.73174071
140MP0005310_abnormal_salivary_gland0.72247982
141MP0003786_premature_aging0.71725477
142MP0002751_abnormal_autonomic_nervous0.71161198
143MP0005257_abnormal_intraocular_pressure0.69432973
144MP0005394_taste/olfaction_phenotype0.69082652
145MP0005499_abnormal_olfactory_system0.69082652
146MP0001853_heart_inflammation0.68929598
147MP0002269_muscular_atrophy0.68524676
148MP0001845_abnormal_inflammatory_respons0.67079111
149MP0004811_abnormal_neuron_physiology0.66942215
150MP0008469_abnormal_protein_level0.65958669
151MP0002063_abnormal_learning/memory/cond0.65817608
152MP0003300_gastrointestinal_ulcer0.64016990
153MP0000266_abnormal_heart_morphology0.63844947
154MP0002064_seizures0.63831704
155MP0004185_abnormal_adipocyte_glucose0.63075983
156MP0002723_abnormal_immune_serum0.62964759
157MP0001835_abnormal_antigen_presentation0.62582490
158MP0002111_abnormal_tail_morphology0.62506986
159MP0005000_abnormal_immune_tolerance0.62477637

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)4.13926617
2Abnormality of glycosphingolipid metabolism (HP:0004343)4.13926617
3Abnormality of glycolipid metabolism (HP:0010969)4.13926617
4Ependymoma (HP:0002888)3.93172238
5Increased cerebral lipofuscin (HP:0011813)3.90506676
6Abnormality of the lower motor neuron (HP:0002366)3.43947159
7Increased neuronal autofluorescent lipopigment (HP:0002074)3.43672048
8Obstructive sleep apnea (HP:0002870)3.41084128
9Supranuclear gaze palsy (HP:0000605)3.29027941
10Selective tooth agenesis (HP:0001592)3.16033675
11Hyperacusis (HP:0010780)3.14650832
12Neuronal loss in central nervous system (HP:0002529)3.10048395
13Dysostosis multiplex (HP:0000943)3.08803886
14Loss of speech (HP:0002371)3.08302790
15Hand muscle atrophy (HP:0009130)3.07513419
16Upper limb amyotrophy (HP:0009129)3.06790368
17Distal upper limb amyotrophy (HP:0007149)3.06790368
18Neurofibrillary tangles (HP:0002185)2.97558092
19Astrocytoma (HP:0009592)2.90826023
20Abnormality of the astrocytes (HP:0100707)2.90826023
21Stridor (HP:0010307)2.90102418
22Mutism (HP:0002300)2.89720429
23Vacuolated lymphocytes (HP:0001922)2.88721861
24Protrusio acetabuli (HP:0003179)2.82551748
25Axonal loss (HP:0003447)2.80961533
26Hypertensive crisis (HP:0100735)2.78865015
27Abnormality of macrophages (HP:0004311)2.72794882
28Cerebral aneurysm (HP:0004944)2.71209396
29Peripheral hypomyelination (HP:0007182)2.69772367
30Cerebral inclusion bodies (HP:0100314)2.68521043
31Renal duplication (HP:0000075)2.63432109
32Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.61702157
33Amyotrophic lateral sclerosis (HP:0007354)2.60640742
34Chronic obstructive pulmonary disease (HP:0006510)2.58962954
35Obstructive lung disease (HP:0006536)2.58962954
36Distal lower limb muscle weakness (HP:0009053)2.58129778
37Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.52025973
38Cellulitis (HP:0100658)2.51801579
39Nuclear cataract (HP:0100018)2.48465364
40Atrophy/Degeneration involving motor neurons (HP:0007373)2.44642119
41Upper motor neuron abnormality (HP:0002127)2.43255578
42Centrally nucleated skeletal muscle fibers (HP:0003687)2.41332994
43Increased connective tissue (HP:0009025)2.37991362
44Annular pancreas (HP:0001734)2.34792344
45Trismus (HP:0000211)2.34267177
46Abnormality of mucopolysaccharide metabolism (HP:0011020)2.33349815
47Abnormality of polysaccharide metabolism (HP:0011012)2.33349815
48Abnormality of glycosaminoglycan metabolism (HP:0004371)2.33349815
49Lower limb amyotrophy (HP:0007210)2.32325288
50Truncus arteriosus (HP:0001660)2.31841002
51Spinal muscular atrophy (HP:0007269)2.29777362
52Eczematoid dermatitis (HP:0000976)2.29248273
53Genu recurvatum (HP:0002816)2.28847911
54Abnormality of the Achilles tendon (HP:0005109)2.28844558
55Recurrent abscess formation (HP:0002722)2.28385116
56Hyperthyroidism (HP:0000836)2.27949371
57Basal cell carcinoma (HP:0002671)2.27871425
58Rib fusion (HP:0000902)2.27442891
59Vertebral compression fractures (HP:0002953)2.27201786
60Pointed chin (HP:0000307)2.25219925
61Bowel diverticulosis (HP:0005222)2.24327278
62Medulloblastoma (HP:0002885)2.22315897
63Increased nuchal translucency (HP:0010880)2.20547416
64Broad face (HP:0000283)2.19423908
65Increased density of long bones (HP:0006392)2.17620268
66Missing ribs (HP:0000921)2.17113259
67Recurrent bacterial skin infections (HP:0005406)2.15929292
68Glioma (HP:0009733)2.15113695
69Systemic lupus erythematosus (HP:0002725)2.13880117
70Abnormality of the motor neurons (HP:0002450)2.13686197
71Abnormal neuron morphology (HP:0012757)2.13686197
72Neoplasm of striated muscle (HP:0009728)2.13658382
73Ankle contracture (HP:0006466)2.13044858
74Cholecystitis (HP:0001082)2.12198840
75Abnormal gallbladder physiology (HP:0012438)2.12198840
76Polygenic inheritance (HP:0010982)2.10949240
77Agnosia (HP:0010524)2.08830219
78Disproportionate tall stature (HP:0001519)2.07792562
79Shallow orbits (HP:0000586)2.06695249
80Insomnia (HP:0100785)2.06639633
81Urinary glycosaminoglycan excretion (HP:0003541)2.06574259
82Mucopolysacchariduria (HP:0008155)2.06574259
83Mediastinal lymphadenopathy (HP:0100721)2.06313579
84Skin tags (HP:0010609)2.06219637
85J-shaped sella turcica (HP:0002680)2.05993578
86Preauricular skin tag (HP:0000384)2.04158505
87Abnormal number of incisors (HP:0011064)2.02519196
88Nasal polyposis (HP:0100582)2.01728268
89Broad distal phalanx of finger (HP:0009836)2.00858873
90Bulbar palsy (HP:0001283)2.00425093
91Ankle clonus (HP:0011448)1.99626567
92Abnormality of the anterior horn cell (HP:0006802)1.98004151
93Degeneration of anterior horn cells (HP:0002398)1.98004151
94Bowel incontinence (HP:0002607)1.97097256
95Angiofibromas (HP:0010615)1.96907014
96Adenoma sebaceum (HP:0009720)1.96907014
97Dementia (HP:0000726)1.96793562
98Thoracic kyphosis (HP:0002942)1.94324322
99Easy fatigability (HP:0003388)1.94056767
100Short 4th metacarpal (HP:0010044)1.93867144
101Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.93867144
102Abnormal large intestine physiology (HP:0012700)1.93737993
103Apathy (HP:0000741)1.90639573
104Ragged-red muscle fibers (HP:0003200)1.88416789
105Difficulty climbing stairs (HP:0003551)1.87900482
106Premature skin wrinkling (HP:0100678)1.87885210
107Rhabdomyosarcoma (HP:0002859)1.87410859
108Neoplasm of the heart (HP:0100544)1.86831563
109Generalized amyotrophy (HP:0003700)1.85901671
110Atelectasis (HP:0100750)1.84985499
111Slow saccadic eye movements (HP:0000514)1.84012394
112Increased serum ferritin (HP:0003281)1.83791534
113Broad palm (HP:0001169)1.83402452
114Diaphragmatic weakness (HP:0009113)1.83345683
115Diminished motivation (HP:0000745)1.82989748
116Premature rupture of membranes (HP:0001788)1.82595401
117Aplasia/hypoplasia of the humerus (HP:0006507)1.81396248
118Acute lymphatic leukemia (HP:0006721)1.81199205
119Increased variability in muscle fiber diameter (HP:0003557)1.80579960
120Slender long bone (HP:0003100)1.80328886
121Long palpebral fissure (HP:0000637)1.80317626
122Turricephaly (HP:0000262)1.80283907
123Purpura (HP:0000979)1.79812333
124Amyloidosis (HP:0011034)1.79247657
125Gastrointestinal dysmotility (HP:0002579)1.79095249
126Abnormality of the thoracic spine (HP:0100711)1.79054972
127Myokymia (HP:0002411)1.78849050
128Short humerus (HP:0005792)1.77216664
129Segmental peripheral demyelination/remyelination (HP:0003481)1.76750784
130Abnormality of the musculature of the hand (HP:0001421)1.76530973
131Multiple enchondromatosis (HP:0005701)1.74875847
132Urethral obstruction (HP:0000796)1.73974434
133Hepatosplenomegaly (HP:0001433)1.73864948
134Elfin facies (HP:0004428)1.72526624
135Patellar dislocation (HP:0002999)1.72372146
136Neoplasm of the oral cavity (HP:0100649)1.72289634
137Abnormality of the nasal mucosa (HP:0000433)1.71987628
138Microvesicular hepatic steatosis (HP:0001414)1.71567505
139Visual hallucinations (HP:0002367)1.70583056
140Joint stiffness (HP:0001387)1.69981554
141Microretrognathia (HP:0000308)1.69685933
142Distal sensory impairment (HP:0002936)1.69682931
143Vertebral fusion (HP:0002948)1.68768028
144Colon cancer (HP:0003003)1.67912196
145Intestinal fistula (HP:0100819)1.67653614
146High pitched voice (HP:0001620)1.66846688
147Achilles tendon contracture (HP:0001771)1.66575581
148Rapidly progressive (HP:0003678)1.65805792
149Reticulocytopenia (HP:0001896)1.64177812
150Deviation of the thumb (HP:0009603)1.63837805
151Tracheoesophageal fistula (HP:0002575)1.63124110
152Proximal placement of thumb (HP:0009623)1.62879047
153Absent thumb (HP:0009777)1.61111517
154Pelvic girdle muscle weakness (HP:0003749)1.60928489
155Abnormality of cells of the erythroid lineage (HP:0012130)1.60468956
156Overriding aorta (HP:0002623)1.60464734
157Bladder diverticulum (HP:0000015)1.60375031
158Fused cervical vertebrae (HP:0002949)1.60360670
159Cervical subluxation (HP:0003308)1.59408230
160Patellar aplasia (HP:0006443)1.59403102
161Distal lower limb amyotrophy (HP:0008944)1.59228993
162Atresia of the external auditory canal (HP:0000413)1.59175610
163Bilateral microphthalmos (HP:0007633)1.58924771
164Bicuspid aortic valve (HP:0001647)1.58824651
16511 pairs of ribs (HP:0000878)1.58633786
166Dislocated radial head (HP:0003083)1.58063181
167Fibroma (HP:0010614)1.57500235
168Prominent nose (HP:0000448)1.57384486
169Malignant neoplasm of the central nervous system (HP:0100836)1.57161731
170Abnormality of abdominal situs (HP:0011620)1.57079004
171Abdominal situs inversus (HP:0003363)1.57079004
172Megalocornea (HP:0000485)1.55675443
173Congenital hip dislocation (HP:0001374)1.54725527
174Short 5th finger (HP:0009237)1.54133271
175Dilatation of the ascending aorta (HP:0005111)1.53360909
176Aplasia/Hypoplasia of the spleen (HP:0010451)1.53256606
177Abnormality of the calcaneus (HP:0008364)1.51917377
178Asplenia (HP:0001746)1.51679357
179Radial bowing (HP:0002986)1.51493706
180Broad thumb (HP:0011304)1.51424872
181Long eyelashes (HP:0000527)1.50882217
182Ulnar bowing (HP:0003031)1.50299816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.25098881
2EEF2K3.52107031
3SMG13.34008822
4TRIB33.12557285
5MAP3K103.05609952
6PRPF4B2.97887926
7PKN22.81619946
8IRAK32.66730737
9BUB12.38664648
10SIK12.35786663
11CDC72.29287450
12GRK61.98290315
13MAP4K11.96828367
14ERN11.93975833
15MAP3K91.79909170
16STK101.74382648
17NEK21.73509984
18TESK21.65511228
19ARAF1.65192009
20CDK71.57316899
21LATS21.56428244
22PAK41.53646339
23WEE11.51871792
24TAOK11.40894989
25RIPK41.40017905
26ICK1.38851952
27SIK21.38763731
28TNK21.38757445
29SCYL21.38246240
30FLT31.37318114
31NEK11.36508318
32ALK1.36086285
33TYRO31.32630743
34EPHB11.28437004
35RPS6KA41.27287275
36RPS6KB21.25805565
37MAP3K81.23167106
38MAP3K11.20854267
39TTK1.19824926
40TBK11.18959158
41PRKD31.18539099
42LRRK21.15928492
43MATK1.13704584
44FES1.12187555
45MAP3K31.11421860
46PLK11.10162175
47TSSK61.09572641
48RPS6KA21.08875015
49RIPK11.07658401
50CSF1R1.04675336
51MAP3K111.04634082
52LIMK11.04554030
53MTOR1.04357805
54MAPKAPK31.02571621
55CDK41.02545041
56CAMK1D0.96946948
57TTN0.96677146
58LMTK20.94359536
59RPS6KC10.94047815
60RPS6KL10.94047815
61PAK60.93652968
62KSR20.92522944
63BRD40.89935485
64PIM20.89269261
65DYRK1B0.88112141
66AURKA0.86949264
67PAK10.86923307
68MOS0.86865147
69IRAK40.86849023
70GRK50.86488833
71PAK20.86369740
72BMX0.86068966
73KIT0.85392639
74ATR0.85381054
75BRSK10.85209011
76BRAF0.84861048
77DAPK20.84065068
78NME20.83787114
79CHEK10.83778007
80PDGFRA0.83619437
81STK380.81004614
82DYRK30.80551445
83DAPK10.80003322
84ABL20.75158160
85PASK0.74671288
86BCKDK0.73395460
87TESK10.71686545
88RPS6KA60.70587723
89TGFBR10.70531065
90CSK0.69354199
91IRAK20.68727917
92MAP3K60.66491915
93NTRK10.66422508
94PTK20.65859207
95FGR0.65718155
96JAK30.65668302
97* CDK20.65276771
98AKT20.65214920
99PDPK10.64825255
100CLK10.64588648
101CAMKK10.64435529
102TIE10.63182340
103CDK11A0.62873220
104MAP2K30.62512790
105MARK20.62431763
106CDK190.60874097
107CHEK20.60583915
108PTK60.60489207
109CDK150.60031265
110TAOK20.59962182
111HIPK20.58535104
112PIM10.58162865
113EPHA20.57480004
114BLK0.57304330
115AURKB0.57238911
116MAP3K70.56839967
117UHMK10.56742786
118MAP3K140.55920211
119CDK180.55811823
120TYK20.55543279
121PRKD20.54083243
122CAMK40.53011815
123KDR0.51576911
124ZAP700.49585971
125MAPK120.49422275
126MAP3K130.49229851
127HCK0.49058563
128EPHB20.48979404
129CDK140.48765719
130RAF10.48655451
131VRK20.45149516
132DDR20.44969691
133TGFBR20.41832883
134IKBKB0.41294310
135CDK90.40932012
136RPS6KA10.40500398
137FGFR40.39804800
138PRKG20.38791387
139MINK10.37314038
140FGFR10.36681791
141CDC42BPA0.35745819
142ATM0.35732683
143BTK0.35531719
144DAPK30.35083281
145SIK30.34233632

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.57993680
2DNA replication_Homo sapiens_hsa030303.13505878
3Mismatch repair_Homo sapiens_hsa034302.52912884
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34048141
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.27273262
6Lysosome_Homo sapiens_hsa041422.27101918
7Spliceosome_Homo sapiens_hsa030402.15775845
8Base excision repair_Homo sapiens_hsa034102.07762044
9Synaptic vesicle cycle_Homo sapiens_hsa047212.03580885
10RNA transport_Homo sapiens_hsa030132.02490076
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81614966
12Cell cycle_Homo sapiens_hsa041101.79686237
13Ribosome_Homo sapiens_hsa030101.73135567
14Pentose phosphate pathway_Homo sapiens_hsa000301.69371475
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52545042
16Vibrio cholerae infection_Homo sapiens_hsa051101.48602436
17mRNA surveillance pathway_Homo sapiens_hsa030151.42777207
18Tuberculosis_Homo sapiens_hsa051521.40116452
19Nucleotide excision repair_Homo sapiens_hsa034201.39866737
20Chronic myeloid leukemia_Homo sapiens_hsa052201.38197693
21Prion diseases_Homo sapiens_hsa050201.36661346
22One carbon pool by folate_Homo sapiens_hsa006701.36564026
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33772739
24Homologous recombination_Homo sapiens_hsa034401.33655768
25Acute myeloid leukemia_Homo sapiens_hsa052211.30084281
26Galactose metabolism_Homo sapiens_hsa000521.26433266
27p53 signaling pathway_Homo sapiens_hsa041151.22630361
28mTOR signaling pathway_Homo sapiens_hsa041501.21565778
29Notch signaling pathway_Homo sapiens_hsa043301.21413520
30Fructose and mannose metabolism_Homo sapiens_hsa000511.21104387
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.20799378
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.20558037
33Colorectal cancer_Homo sapiens_hsa052101.20321323
34Phagosome_Homo sapiens_hsa041451.18246838
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15999982
36HTLV-I infection_Homo sapiens_hsa051661.13562444
37Thyroid cancer_Homo sapiens_hsa052161.13519202
38RNA polymerase_Homo sapiens_hsa030201.13264341
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12850745
40Sulfur relay system_Homo sapiens_hsa041221.10773012
41B cell receptor signaling pathway_Homo sapiens_hsa046621.08866497
42Shigellosis_Homo sapiens_hsa051311.07447500
43VEGF signaling pathway_Homo sapiens_hsa043701.07361834
44Collecting duct acid secretion_Homo sapiens_hsa049661.06857889
45Rheumatoid arthritis_Homo sapiens_hsa053231.06507630
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06001388
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04830866
48Antigen processing and presentation_Homo sapiens_hsa046121.04267564
49Epstein-Barr virus infection_Homo sapiens_hsa051691.04098117
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03485933
51Oocyte meiosis_Homo sapiens_hsa041141.02014177
52Bladder cancer_Homo sapiens_hsa052191.01735141
53Viral carcinogenesis_Homo sapiens_hsa052031.00276122
54Non-small cell lung cancer_Homo sapiens_hsa052230.98190943
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.98089778
56MicroRNAs in cancer_Homo sapiens_hsa052060.97765006
57Apoptosis_Homo sapiens_hsa042100.97575095
58Pyrimidine metabolism_Homo sapiens_hsa002400.96123143
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95427759
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94625501
61Glioma_Homo sapiens_hsa052140.93647352
62Pertussis_Homo sapiens_hsa051330.91394696
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91121667
64Fanconi anemia pathway_Homo sapiens_hsa034600.90874200
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87314484
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86453917
67RNA degradation_Homo sapiens_hsa030180.85950937
68Hepatitis B_Homo sapiens_hsa051610.85514614
69HIF-1 signaling pathway_Homo sapiens_hsa040660.84816281
70Staphylococcus aureus infection_Homo sapiens_hsa051500.84593164
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83844925
72Insulin signaling pathway_Homo sapiens_hsa049100.82556914
73Pancreatic cancer_Homo sapiens_hsa052120.82522019
74Hippo signaling pathway_Homo sapiens_hsa043900.81390929
75Chemokine signaling pathway_Homo sapiens_hsa040620.80946675
76Biosynthesis of amino acids_Homo sapiens_hsa012300.80839629
77Small cell lung cancer_Homo sapiens_hsa052220.80579257
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78535249
79Malaria_Homo sapiens_hsa051440.78112921
80Proteoglycans in cancer_Homo sapiens_hsa052050.77709547
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77271260
82Herpes simplex infection_Homo sapiens_hsa051680.76411647
83Amoebiasis_Homo sapiens_hsa051460.76399884
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75070741
85Long-term potentiation_Homo sapiens_hsa047200.73807808
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73776044
87Leishmaniasis_Homo sapiens_hsa051400.73215037
88Basal cell carcinoma_Homo sapiens_hsa052170.72251114
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71663386
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71201222
91Endometrial cancer_Homo sapiens_hsa052130.71056497
92Hepatitis C_Homo sapiens_hsa051600.70851598
93T cell receptor signaling pathway_Homo sapiens_hsa046600.70601011
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69771934
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69716093
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.69452686
97Osteoclast differentiation_Homo sapiens_hsa043800.69336803
98Proteasome_Homo sapiens_hsa030500.68833183
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68515054
100Estrogen signaling pathway_Homo sapiens_hsa049150.67346129
101Pathways in cancer_Homo sapiens_hsa052000.66526053
102Primary immunodeficiency_Homo sapiens_hsa053400.66173449
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65485718
104Inositol phosphate metabolism_Homo sapiens_hsa005620.65086723
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64990975
106AMPK signaling pathway_Homo sapiens_hsa041520.64098595
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.63538355
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62420434
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61915475
110Rap1 signaling pathway_Homo sapiens_hsa040150.61752638
111Measles_Homo sapiens_hsa051620.61578787
112Non-homologous end-joining_Homo sapiens_hsa034500.60321734
113Viral myocarditis_Homo sapiens_hsa054160.59952198
114Prolactin signaling pathway_Homo sapiens_hsa049170.59822911
115Legionellosis_Homo sapiens_hsa051340.59022059
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.58504116
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56272317
118Gap junction_Homo sapiens_hsa045400.56256858
119Hedgehog signaling pathway_Homo sapiens_hsa043400.55578557
120Salmonella infection_Homo sapiens_hsa051320.55310873
121MAPK signaling pathway_Homo sapiens_hsa040100.55216492
122ErbB signaling pathway_Homo sapiens_hsa040120.54685894
123Adherens junction_Homo sapiens_hsa045200.54063002
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.53969201
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.53183650
126Endocytosis_Homo sapiens_hsa041440.53164982
127Focal adhesion_Homo sapiens_hsa045100.52793151
128TNF signaling pathway_Homo sapiens_hsa046680.52752000
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52641948
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52423029
131Toxoplasmosis_Homo sapiens_hsa051450.52209189
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52042006
133Influenza A_Homo sapiens_hsa051640.51414915
134GnRH signaling pathway_Homo sapiens_hsa049120.51028121
135Renal cell carcinoma_Homo sapiens_hsa052110.50895164
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50524385
137Platelet activation_Homo sapiens_hsa046110.50015585
138Wnt signaling pathway_Homo sapiens_hsa043100.49918500
139Choline metabolism in cancer_Homo sapiens_hsa052310.48706354
140Allograft rejection_Homo sapiens_hsa053300.48635863
141Axon guidance_Homo sapiens_hsa043600.47324975
1422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47070961
143Type II diabetes mellitus_Homo sapiens_hsa049300.45652096

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