MAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.19427964
2synaptic vesicle maturation (GO:0016188)6.12304096
3locomotory exploration behavior (GO:0035641)6.07677463
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.65994817
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.51252783
6vocalization behavior (GO:0071625)5.49309124
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.24701103
8layer formation in cerebral cortex (GO:0021819)5.24321387
9synaptic vesicle exocytosis (GO:0016079)5.09246612
10glutamate secretion (GO:0014047)5.06587991
11regulation of glutamate receptor signaling pathway (GO:1900449)4.96428698
12regulation of synaptic vesicle exocytosis (GO:2000300)4.95528737
13protein localization to synapse (GO:0035418)4.90205564
14exploration behavior (GO:0035640)4.88309087
15neuron cell-cell adhesion (GO:0007158)4.87094371
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.83912848
17dendritic spine morphogenesis (GO:0060997)4.73830835
18regulation of synapse structural plasticity (GO:0051823)4.66641613
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.45922761
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.42419771
21regulation of synaptic vesicle transport (GO:1902803)4.38109102
22regulation of neuronal synaptic plasticity (GO:0048168)4.36417946
23neurotransmitter secretion (GO:0007269)4.33249915
24establishment of mitochondrion localization (GO:0051654)4.27108290
25neurotransmitter-gated ion channel clustering (GO:0072578)4.23120317
26proline transport (GO:0015824)4.18627579
27synaptic transmission, glutamatergic (GO:0035249)4.03621316
28gamma-aminobutyric acid transport (GO:0015812)4.02946719
29neuron recognition (GO:0008038)4.01716101
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.99032572
31glutamate receptor signaling pathway (GO:0007215)3.93485867
32axonal fasciculation (GO:0007413)3.85294628
33* dendrite morphogenesis (GO:0048813)3.81891452
34long-term memory (GO:0007616)3.76477689
35pyrimidine nucleobase catabolic process (GO:0006208)3.76150661
36neuron-neuron synaptic transmission (GO:0007270)3.75350847
37positive regulation of membrane potential (GO:0045838)3.74490856
38positive regulation of synapse maturation (GO:0090129)3.74110403
39activation of protein kinase A activity (GO:0034199)3.73753719
40postsynaptic membrane organization (GO:0001941)3.73264452
41mechanosensory behavior (GO:0007638)3.69874510
42regulation of dendritic spine morphogenesis (GO:0061001)3.66064740
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.64019506
44cell migration in hindbrain (GO:0021535)3.63013493
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.60902248
46neuronal action potential propagation (GO:0019227)3.60813142
47central nervous system projection neuron axonogenesis (GO:0021952)3.59896529
48auditory behavior (GO:0031223)3.58312390
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.56897512
50neuromuscular process controlling balance (GO:0050885)3.54461644
51startle response (GO:0001964)3.52540025
52establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.50711001
53mitochondrion transport along microtubule (GO:0047497)3.50711001
54positive regulation of synapse assembly (GO:0051965)3.48389793
55positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.44748004
56neurotransmitter transport (GO:0006836)3.44395894
57cellular potassium ion homeostasis (GO:0030007)3.43753250
58response to auditory stimulus (GO:0010996)3.43439309
59regulation of postsynaptic membrane potential (GO:0060078)3.43226603
60positive regulation of synaptic transmission, GABAergic (GO:0032230)3.42340832
61sodium ion export (GO:0071436)3.36925569
62negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.36679802
63transmission of nerve impulse (GO:0019226)3.36031267
64regulation of synaptic plasticity (GO:0048167)3.34827479
65synaptic vesicle endocytosis (GO:0048488)3.33081989
66cerebral cortex radially oriented cell migration (GO:0021799)3.28099844
67regulation of neurotransmitter secretion (GO:0046928)3.28009863
68vesicle transport along microtubule (GO:0047496)3.26468120
69central nervous system neuron axonogenesis (GO:0021955)3.26159463
70prepulse inhibition (GO:0060134)3.24170156
71regulation of synaptic transmission, glutamatergic (GO:0051966)3.23086220
72innervation (GO:0060384)3.22737552
73organelle transport along microtubule (GO:0072384)3.22177158
74regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.21705445
75synapse assembly (GO:0007416)3.20506972
76positive regulation of dendritic spine morphogenesis (GO:0061003)3.20046100
77cerebellar Purkinje cell differentiation (GO:0021702)3.19474240
78presynaptic membrane assembly (GO:0097105)3.18333252
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.17356478
80dendritic spine organization (GO:0097061)3.17243882
81cell communication by electrical coupling (GO:0010644)3.16209555
82clathrin coat assembly (GO:0048268)3.15837039
83establishment of nucleus localization (GO:0040023)3.15716978
84adult walking behavior (GO:0007628)3.15383740
85regulation of neurotransmitter levels (GO:0001505)3.15032519
86nucleobase catabolic process (GO:0046113)3.15019665
87negative regulation of synaptic transmission, GABAergic (GO:0032229)3.13584533
88positive regulation of dendritic spine development (GO:0060999)3.13510824
89membrane depolarization during action potential (GO:0086010)3.11959259
90regulation of ARF protein signal transduction (GO:0032012)3.10910727
91G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.09857511
92cerebellar granule cell differentiation (GO:0021707)3.09158743
93retinal ganglion cell axon guidance (GO:0031290)3.08553539
94regulation of dendritic spine development (GO:0060998)3.07996841
95negative regulation of dendrite development (GO:2000171)3.07032478
96long-term synaptic potentiation (GO:0060291)3.06426314
97positive regulation of neurotransmitter secretion (GO:0001956)3.05996425
98cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.03906319
99glycine transport (GO:0015816)3.03580698
100regulation of vesicle fusion (GO:0031338)3.02466272
101neuromuscular synaptic transmission (GO:0007274)3.02329720
102social behavior (GO:0035176)3.01087509
103intraspecies interaction between organisms (GO:0051703)3.01087509
104regulation of neurotransmitter transport (GO:0051588)2.99098304
105neuronal ion channel clustering (GO:0045161)2.98484979
106learning (GO:0007612)2.97524595
107synapse organization (GO:0050808)2.97400808
108presynaptic membrane organization (GO:0097090)2.96419949
109cerebellar Purkinje cell layer development (GO:0021680)2.96063425
110gamma-aminobutyric acid signaling pathway (GO:0007214)2.94399907
111axon cargo transport (GO:0008088)2.93716487
112regulation of synapse assembly (GO:0051963)2.93630741
113membrane hyperpolarization (GO:0060081)2.92400842
114behavioral defense response (GO:0002209)2.92351283
115behavioral fear response (GO:0001662)2.92351283
116positive regulation of neurotransmitter transport (GO:0051590)2.91414268
117membrane depolarization (GO:0051899)2.90246457
118axon extension (GO:0048675)2.88425571
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.85623118
120calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.84101437
121negative regulation of axonogenesis (GO:0050771)2.82060715
122spinal cord development (GO:0021510)2.80025040
123behavioral response to nicotine (GO:0035095)2.79313317
124limb bud formation (GO:0060174)2.78896054
125glycosphingolipid biosynthetic process (GO:0006688)2.78648393
126hippocampus development (GO:0021766)2.75662719
127negative regulation of axon extension (GO:0030517)2.73695347
128central nervous system myelination (GO:0022010)2.73190538
129axon ensheathment in central nervous system (GO:0032291)2.73190538

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.02963324
2GBX2_23144817_ChIP-Seq_PC3_Human3.37971804
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00441466
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97738012
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.88435873
6REST_21632747_ChIP-Seq_MESCs_Mouse2.76989406
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59687014
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59687014
9DROSHA_22980978_ChIP-Seq_HELA_Human2.57492353
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.55224173
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.53323977
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52133132
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45583354
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44707579
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43515546
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42499168
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36436396
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.30830079
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.26946269
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.26605061
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24993118
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.24710683
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24118325
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.19804757
25RBPJ_22232070_ChIP-Seq_NCS_Mouse2.18893081
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15926894
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.12359829
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06462489
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04911853
30AR_21572438_ChIP-Seq_LNCaP_Human2.04485222
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.89675512
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.86225179
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78157065
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72265413
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65930977
36ZNF274_21170338_ChIP-Seq_K562_Hela1.59601449
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56538396
38SMAD4_21799915_ChIP-Seq_A2780_Human1.55591830
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.52158546
40FUS_26573619_Chip-Seq_HEK293_Human1.48450181
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45405464
42RING1B_27294783_Chip-Seq_ESCs_Mouse1.40582064
43* SOX2_21211035_ChIP-Seq_LN229_Gbm1.37374635
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37262011
45TAF15_26573619_Chip-Seq_HEK293_Human1.33905498
46* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31725866
47RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31502015
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28688060
49IGF1R_20145208_ChIP-Seq_DFB_Human1.27739544
50AR_19668381_ChIP-Seq_PC3_Human1.27420676
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26809132
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.25991761
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25721493
54RING1B_27294783_Chip-Seq_NPCs_Mouse1.25211536
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25102490
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.24669556
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24378136
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24257932
59TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22953460
60WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21743768
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21704859
62AR_25329375_ChIP-Seq_VCAP_Human1.21613988
63* P300_19829295_ChIP-Seq_ESCs_Human1.21441902
64* STAT3_23295773_ChIP-Seq_U87_Human1.21163320
65KDM2B_26808549_Chip-Seq_K562_Human1.21056612
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18077529
67* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16784802
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.16393270
69YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15579865
70* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14508227
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.13693512
72* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12854691
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.12441632
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11973278
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11844729
76* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11744222
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11226933
78LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09752717
79EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09573722
80SOX9_26525672_Chip-Seq_HEART_Mouse1.09216537
81STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08519060
82AHR_22903824_ChIP-Seq_MCF-7_Human1.07077346
83RNF2_27304074_Chip-Seq_NSC_Mouse1.06901473
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.06457121
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06411434
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.05695247
87* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05160945
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04733713
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04529282
90* TCF4_23295773_ChIP-Seq_U87_Human1.04173346
91VDR_22108803_ChIP-Seq_LS180_Human1.03818783
92* EWS_26573619_Chip-Seq_HEK293_Human1.03311469
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03160267
94* SMAD3_21741376_ChIP-Seq_ESCs_Human0.98337684
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98217591
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98102761
97SMAD4_21741376_ChIP-Seq_HESCs_Human0.97471704
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97193752
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97118429
100CBP_20019798_ChIP-Seq_JUKART_Human0.97051985
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97051985
102JUN_21703547_ChIP-Seq_K562_Human0.96633289
103GATA1_26923725_Chip-Seq_HPCs_Mouse0.96361202
104ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95773598
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94348514
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94139158
107KDM2B_26808549_Chip-Seq_REH_Human0.93435640
108* RUNX2_22187159_ChIP-Seq_PCA_Human0.93159000
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92822849
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92822849
111TP53_16413492_ChIP-PET_HCT116_Human0.92065422
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91113980
113BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90999097
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89531016
115PRDM14_20953172_ChIP-Seq_ESCs_Human0.89409161
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87804582
117SMAD3_21741376_ChIP-Seq_HESCs_Human0.87728418
118OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.87433123
119* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86823009
120GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86025350
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85272829
122DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84451730
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84167099

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.73953239
2MP0003880_abnormal_central_pattern4.45974918
3MP0003635_abnormal_synaptic_transmissio4.16731742
4MP0004270_analgesia4.09027334
5MP0002063_abnormal_learning/memory/cond3.42623152
6MP0005423_abnormal_somatic_nervous3.41661234
7MP0009745_abnormal_behavioral_response3.23068544
8MP0002064_seizures2.94331592
9MP0009046_muscle_twitch2.78777778
10MP0002734_abnormal_mechanical_nocicepti2.75089292
11MP0001968_abnormal_touch/_nociception2.73843514
12MP0002572_abnormal_emotion/affect_behav2.71287148
13MP0001486_abnormal_startle_reflex2.52338767
14MP0000778_abnormal_nervous_system2.38775113
15MP0009780_abnormal_chondrocyte_physiolo2.30360314
16MP0002272_abnormal_nervous_system2.24283349
17MP0002822_catalepsy2.18502058
18MP0001440_abnormal_grooming_behavior2.06524536
19MP0002735_abnormal_chemical_nociception2.05953852
20MP0002733_abnormal_thermal_nociception2.05334536
21MP0004811_abnormal_neuron_physiology2.01250916
22MP0002184_abnormal_innervation1.97774856
23MP0000569_abnormal_digit_pigmentation1.97287997
24MP0004858_abnormal_nervous_system1.95890186
25MP0002736_abnormal_nociception_after1.91958942
26MP0002909_abnormal_adrenal_gland1.90526902
27MP0003329_amyloid_beta_deposits1.89255071
28MP0001501_abnormal_sleep_pattern1.89009090
29MP0001970_abnormal_pain_threshold1.87893426
30MP0002557_abnormal_social/conspecific_i1.87262774
31MP0002067_abnormal_sensory_capabilities1.85195247
32MP0008569_lethality_at_weaning1.80246976
33MP0004924_abnormal_behavior1.79223784
34MP0005386_behavior/neurological_phenoty1.79223784
35MP0000955_abnormal_spinal_cord1.78584614
36MP0004885_abnormal_endolymph1.77105509
37MP0003121_genomic_imprinting1.74751431
38MP0005645_abnormal_hypothalamus_physiol1.59682183
39MP0005646_abnormal_pituitary_gland1.58766082
40MP0003787_abnormal_imprinting1.55907200
41MP0002882_abnormal_neuron_morphology1.54905481
42MP0006276_abnormal_autonomic_nervous1.52929760
43MP0001984_abnormal_olfaction1.46318620
44MP0002066_abnormal_motor_capabilities/c1.43276697
45MP0003879_abnormal_hair_cell1.40655651
46MP0002152_abnormal_brain_morphology1.30434718
47MP0003633_abnormal_nervous_system1.29483819
48MP0001502_abnormal_circadian_rhythm1.19818923
49MP0003122_maternal_imprinting1.15206252
50MP0002751_abnormal_autonomic_nervous1.13437730
51MP0003631_nervous_system_phenotype1.10023336
52MP0001529_abnormal_vocalization1.07325205
53MP0003283_abnormal_digestive_organ1.07043460
54MP0004133_heterotaxia1.05973715
55MP0002653_abnormal_ependyma_morphology1.05169767
56MP0008877_abnormal_DNA_methylation1.04818921
57MP0000631_abnormal_neuroendocrine_gland1.03754986
58MP0000566_synostosis1.02545302
59MP0004142_abnormal_muscle_tone1.01728632
60MP0008961_abnormal_basal_metabolism1.01140653
61MP0002102_abnormal_ear_morphology0.99662693
62MP0003634_abnormal_glial_cell0.97965947
63MP0001905_abnormal_dopamine_level0.97204411
64MP0001177_atelectasis0.97176492
65MP0008789_abnormal_olfactory_epithelium0.96064220
66MP0002069_abnormal_eating/drinking_beha0.95952579
67MP0005187_abnormal_penis_morphology0.95603085
68MP0000026_abnormal_inner_ear0.94066992
69MP0005551_abnormal_eye_electrophysiolog0.94054449
70MP0002229_neurodegeneration0.93497266
71MP0005253_abnormal_eye_physiology0.91151643
72MP0003938_abnormal_ear_development0.90844876
73MP0005499_abnormal_olfactory_system0.89403608
74MP0005394_taste/olfaction_phenotype0.89403608
75MP0001188_hyperpigmentation0.88284223
76MP0003123_paternal_imprinting0.87003193
77MP0006292_abnormal_olfactory_placode0.86606552
78MP0004742_abnormal_vestibular_system0.85383325
79MP0003861_abnormal_nervous_system0.84667693
80MP0003690_abnormal_glial_cell0.84489237
81MP0003632_abnormal_nervous_system0.83235049
82MP0000751_myopathy0.81857254
83MP0003119_abnormal_digestive_system0.81775167
84MP0002752_abnormal_somatic_nervous0.80647286
85MP0004085_abnormal_heartbeat0.80543390
86MP0001299_abnormal_eye_distance/0.80421624
87MP0000604_amyloidosis0.78615527
88MP0000013_abnormal_adipose_tissue0.77325335
89MP0005248_abnormal_Harderian_gland0.76854561
90MP0000049_abnormal_middle_ear0.76015395
91MP0003137_abnormal_impulse_conducting0.75381666
92MP0001963_abnormal_hearing_physiology0.72383937
93MP0008872_abnormal_physiological_respon0.72330351
94MP0002081_perinatal_lethality0.71975918
95MP0002090_abnormal_vision0.71888671
96MP0004145_abnormal_muscle_electrophysio0.70840754
97MP0010234_abnormal_vibrissa_follicle0.69931219
98MP0010386_abnormal_urinary_bladder0.69534813
99MP0002638_abnormal_pupillary_reflex0.68462997
100MP0003890_abnormal_embryonic-extraembry0.68128123
101MP0000920_abnormal_myelination0.68032159
102MP0005535_abnormal_body_temperature0.67864362
103MP0001348_abnormal_lacrimal_gland0.67680791
104MP0008874_decreased_physiological_sensi0.67416813
105MP0005195_abnormal_posterior_eye0.66154110
106MP0003075_altered_response_to0.65047023
107MP0003172_abnormal_lysosome_physiology0.64439399
108MP0001986_abnormal_taste_sensitivity0.64374370
109MP0004233_abnormal_muscle_weight0.62748518
110MP0003385_abnormal_body_wall0.62505012
111MP0006072_abnormal_retinal_apoptosis0.61990410
112MP0002233_abnormal_nose_morphology0.61594952
113MP0010769_abnormal_survival0.60904745
114MP0001943_abnormal_respiration0.59477943
115MP0010770_preweaning_lethality0.59367486
116MP0002082_postnatal_lethality0.59367486
117MP0002234_abnormal_pharynx_morphology0.58456185
118MP0005623_abnormal_meninges_morphology0.57955066
119MP0004215_abnormal_myocardial_fiber0.57050426
120MP0010768_mortality/aging0.56659654
121MP0001485_abnormal_pinna_reflex0.55416330
122MP0004130_abnormal_muscle_cell0.54665639

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.18285496
2Focal motor seizures (HP:0011153)6.14214601
3Focal seizures (HP:0007359)5.06849097
4Visual hallucinations (HP:0002367)4.85578483
5Epileptic encephalopathy (HP:0200134)4.21010901
6Supranuclear gaze palsy (HP:0000605)3.97394361
7Progressive cerebellar ataxia (HP:0002073)3.89995177
8Papilledema (HP:0001085)3.86311995
9Ankle clonus (HP:0011448)3.85217437
10Mutism (HP:0002300)3.83489079
11Action tremor (HP:0002345)3.59414119
12Broad-based gait (HP:0002136)3.55007854
13Absence seizures (HP:0002121)3.47078006
14Febrile seizures (HP:0002373)3.43974337
15Atonic seizures (HP:0010819)3.38989147
16Poor eye contact (HP:0000817)3.36176100
17Generalized tonic-clonic seizures (HP:0002069)3.28965660
18Urinary bladder sphincter dysfunction (HP:0002839)3.23188551
19Impaired vibration sensation in the lower limbs (HP:0002166)3.21255712
20Drooling (HP:0002307)3.14549316
21Excessive salivation (HP:0003781)3.14549316
22Dialeptic seizures (HP:0011146)3.13062922
23Amyotrophic lateral sclerosis (HP:0007354)3.10797520
24Depression (HP:0000716)3.10274280
25Abnormal social behavior (HP:0012433)3.03050393
26Impaired social interactions (HP:0000735)3.03050393
27Urinary urgency (HP:0000012)2.95600037
28Genetic anticipation (HP:0003743)2.94229773
29Hyperventilation (HP:0002883)2.92563654
30Truncal ataxia (HP:0002078)2.90525936
31Megalencephaly (HP:0001355)2.88839694
32Abnormality of the lower motor neuron (HP:0002366)2.88100502
33Abnormal eating behavior (HP:0100738)2.86406287
34Abnormality of the corticospinal tract (HP:0002492)2.82888750
35Neurofibrillary tangles (HP:0002185)2.82653112
36Gait imbalance (HP:0002141)2.81228218
37Dysdiadochokinesis (HP:0002075)2.80491430
38Postural instability (HP:0002172)2.79259198
39Progressive inability to walk (HP:0002505)2.76748695
40Cerebral inclusion bodies (HP:0100314)2.73208658
41Gaze-evoked nystagmus (HP:0000640)2.72652686
42Spastic gait (HP:0002064)2.71467310
43Hemiparesis (HP:0001269)2.70433870
44Termporal pattern (HP:0011008)2.65063461
45Insidious onset (HP:0003587)2.65063461
46Anxiety (HP:0000739)2.63618954
47Torticollis (HP:0000473)2.61435106
48Dysmetria (HP:0001310)2.59650604
49Limb dystonia (HP:0002451)2.59552641
50Diplopia (HP:0000651)2.58529033
51Abnormality of binocular vision (HP:0011514)2.58529033
52Amblyopia (HP:0000646)2.57971262
53Inappropriate behavior (HP:0000719)2.57075224
54Agitation (HP:0000713)2.55736995
55Intention tremor (HP:0002080)2.50759961
56Impaired smooth pursuit (HP:0007772)2.50624561
57Epileptiform EEG discharges (HP:0011182)2.48751286
58Polyphagia (HP:0002591)2.47754124
59EEG with generalized epileptiform discharges (HP:0011198)2.47025610
60Cortical dysplasia (HP:0002539)2.43832781
61Fetal akinesia sequence (HP:0001989)2.43021999
62Hypsarrhythmia (HP:0002521)2.42251018
63Stereotypic behavior (HP:0000733)2.42194665
64Insomnia (HP:0100785)2.37658252
65Lower limb muscle weakness (HP:0007340)2.36786548
66Degeneration of the lateral corticospinal tracts (HP:0002314)2.34800302
67Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.34800302
68Akinesia (HP:0002304)2.33586606
69Bradykinesia (HP:0002067)2.33159230
70Focal dystonia (HP:0004373)2.32732599
71Abnormality of the labia minora (HP:0012880)2.30289426
72Spastic tetraplegia (HP:0002510)2.29738967
73Apathy (HP:0000741)2.24340659
74Abnormality of ocular smooth pursuit (HP:0000617)2.24084342
75Absent speech (HP:0001344)2.22207466
76Specific learning disability (HP:0001328)2.20083850
77Obstructive sleep apnea (HP:0002870)2.19566238
78Inability to walk (HP:0002540)2.18945321
79Hemiplegia (HP:0002301)2.17605497
80Status epilepticus (HP:0002133)2.17286065
81Scanning speech (HP:0002168)2.16754101
82Retinal dysplasia (HP:0007973)2.15668962
83Pheochromocytoma (HP:0002666)2.15157636
84Pointed chin (HP:0000307)2.12974135
85Exotropia (HP:0000577)2.12843133
86Aqueductal stenosis (HP:0002410)2.10549824
87Medial flaring of the eyebrow (HP:0010747)2.10309085
88Craniofacial dystonia (HP:0012179)2.10281152
89Congenital primary aphakia (HP:0007707)2.09929051
90Sleep apnea (HP:0010535)2.09277768
91Clonus (HP:0002169)2.06710713
92Impaired vibratory sensation (HP:0002495)2.06160346
93Hypoplasia of the corpus callosum (HP:0002079)2.04778901
94Abnormality of salivation (HP:0100755)2.02108276
95Nephrogenic diabetes insipidus (HP:0009806)2.01654101
96Split foot (HP:0001839)2.01600329
97Lower limb amyotrophy (HP:0007210)2.00170136
98Genital tract atresia (HP:0001827)1.99225132
99Macroorchidism (HP:0000053)1.98999430
100Oligodactyly (hands) (HP:0001180)1.97958728
101Vaginal atresia (HP:0000148)1.97752585
102Diminished motivation (HP:0000745)1.96978542
103Ventricular fibrillation (HP:0001663)1.96156723
104Ankyloglossia (HP:0010296)1.96099133
105Blue irides (HP:0000635)1.95502923
106Hepatoblastoma (HP:0002884)1.92543272
107Optic nerve hypoplasia (HP:0000609)1.91278044
108Morphological abnormality of the pyramidal tract (HP:0002062)1.90229427
109Hypoplasia of the brainstem (HP:0002365)1.90122072
110Aplasia/Hypoplasia of the brainstem (HP:0007362)1.90122072
111Generalized myoclonic seizures (HP:0002123)1.88902352
112Peripheral hypomyelination (HP:0007182)1.85460140
113True hermaphroditism (HP:0010459)1.84818418
114Neuronal loss in central nervous system (HP:0002529)1.84705435
115Esotropia (HP:0000565)1.84323115
116Intellectual disability, profound (HP:0002187)1.84305457
117Nephronophthisis (HP:0000090)1.83717201
118Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82145516
119Lissencephaly (HP:0001339)1.80838074
120Pachygyria (HP:0001302)1.80591598
121Protruding tongue (HP:0010808)1.80558022
122Dysmetric saccades (HP:0000641)1.79589491
123Muscular hypotonia of the trunk (HP:0008936)1.78319766
124Failure to thrive in infancy (HP:0001531)1.77817652
125Cutaneous finger syndactyly (HP:0010554)1.76826890
126Intellectual disability, severe (HP:0010864)1.75423167
127Gait ataxia (HP:0002066)1.75058088
128Neuroendocrine neoplasm (HP:0100634)1.74973213
129Intestinal atresia (HP:0011100)1.72123889
130Renal hypoplasia (HP:0000089)1.67879559
131Pancreatic fibrosis (HP:0100732)1.64803945

Predicted kinase interactions (KEA)

RankGene SetZ-score
1* MARK14.65986896
2MAP3K94.13989640
3NTRK34.00746490
4EPHA43.56790328
5MAP3K42.97360673
6MINK12.83385958
7NTRK22.76159552
8MAP2K72.40866333
9DAPK22.40622677
10PAK62.28653713
11PRKD31.93908557
12KSR11.90799403
13KSR21.89130401
14CAMKK11.89075942
15MAPK131.81608627
16NTRK11.79026998
17MAP2K41.72226182
18PHKG21.67126217
19PHKG11.67126217
20TNIK1.63426715
21CDK51.59438188
22SIK21.51665333
23CASK1.48476442
24TYRO31.39585665
25LATS21.39035789
26DAPK11.31323074
27MAP3K21.28317634
28MAP3K121.25312521
29TRIM281.23662413
30UHMK11.21375852
31ERBB31.18833616
32PLK21.15691751
33TAOK11.15001342
34EPHA31.11670753
35STK381.10954800
36PRKCG1.10541026
37EPHB21.09875403
38CSNK1G21.08050053
39PRPF4B1.06158027
40RET1.01594850
41DYRK21.00760500
42SCYL20.97544572
43PNCK0.97391317
44PAK30.96653764
45STK110.95876186
46GRK50.95730779
47CDK190.94127565
48CDK180.93987485
49CDK150.92414208
50CSNK1G10.90302155
51FES0.89623775
52MARK20.89576121
53RIPK40.89442118
54CDK140.89366384
55CAMKK20.88979854
56MAP4K20.87147002
57ALK0.87111061
58DYRK1A0.82700658
59SGK2230.82616552
60SGK4940.82616552
61FRK0.80607831
62CDK11A0.80005499
63CAMK2A0.79860348
64PRKCH0.79137485
65WNK30.73855829
66LMTK20.71394036
67CAMK10.71348151
68FGFR20.70230395
69PRKCZ0.69038385
70SGK20.66578174
71SGK10.66115314
72SGK30.63182066
73CAMK1G0.62658601
74DYRK30.57829612
75CAMK2B0.57228922
76RAF10.56794473
77PKN10.54759406
78RIPK10.54282310
79DYRK1B0.52645372
80MAP3K60.52413176
81BMPR1B0.52100214
82RPS6KA20.51979766
83CDC42BPA0.51684029
84* RPS6KA30.48711915
85CAMK2G0.46958301
86MKNK20.46869371
87CCNB10.46842668
88PDK10.46260354
89CSNK1G30.46105985
90CSNK1A1L0.44228492
91* FYN0.43872368
92MAPK100.43513039
93BRSK10.43413935
94ERBB20.43290337
95PRKCE0.42973154
96CSNK1E0.42824442
97LIMK10.42475825
98CDK30.42464864
99ARAF0.42227401
100PDPK10.42089157
101BRD40.41938576
102NEK10.41276301
103PRKG10.40028374
104INSRR0.39902705
105CAMK2D0.39754717
106PINK10.39538713
107AKT30.38604736
108ICK0.38106560
109ADRBK20.37574733
110CSNK1A10.36677722
111MAPK120.36425964
112ROCK20.35913027
113MAP3K130.35779761
114PDGFRA0.35670282
115BCR0.35017081
116STK390.34779767
117OXSR10.34722399
118RPS6KA40.34603951
119* PRKACA0.33891475
120PRKACB0.33688427
121MAP3K10.33194076
122CAMK40.33005719
123* CSNK1D0.33003688
124PRKCB0.32435941
125FER0.32334065
126WNK40.31634241
127MAPK90.31283253
128ROCK10.31124927
129DMPK0.31040612
130MAPK80.30731722
131PRKAA10.29958389
132* GSK3B0.29352609

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.38188974
2Synaptic vesicle cycle_Homo sapiens_hsa047212.99701344
3GABAergic synapse_Homo sapiens_hsa047272.67298108
4Circadian entrainment_Homo sapiens_hsa047132.65173863
5Olfactory transduction_Homo sapiens_hsa047402.64397820
6Glutamatergic synapse_Homo sapiens_hsa047242.51933180
7Long-term potentiation_Homo sapiens_hsa047202.48405311
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.47600946
9Morphine addiction_Homo sapiens_hsa050322.39734192
10Amphetamine addiction_Homo sapiens_hsa050312.23782479
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23554514
12Dopaminergic synapse_Homo sapiens_hsa047282.18708139
13Cholinergic synapse_Homo sapiens_hsa047251.98194836
14Salivary secretion_Homo sapiens_hsa049701.97583118
15Insulin secretion_Homo sapiens_hsa049111.97310799
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84635511
17Gastric acid secretion_Homo sapiens_hsa049711.79902154
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.78197649
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69070773
20Cocaine addiction_Homo sapiens_hsa050301.67213476
21Renin secretion_Homo sapiens_hsa049241.64229599
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61333175
23Oxytocin signaling pathway_Homo sapiens_hsa049211.60335981
24Long-term depression_Homo sapiens_hsa047301.58184144
25Serotonergic synapse_Homo sapiens_hsa047261.53222354
26Taste transduction_Homo sapiens_hsa047421.51519995
27Axon guidance_Homo sapiens_hsa043601.50436444
28Gap junction_Homo sapiens_hsa045401.46760142
29GnRH signaling pathway_Homo sapiens_hsa049121.45605217
30Type II diabetes mellitus_Homo sapiens_hsa049301.40978075
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36866667
32Calcium signaling pathway_Homo sapiens_hsa040201.35206112
33Glioma_Homo sapiens_hsa052141.31250749
34Estrogen signaling pathway_Homo sapiens_hsa049151.29285481
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25961803
36cAMP signaling pathway_Homo sapiens_hsa040241.22741566
37ErbB signaling pathway_Homo sapiens_hsa040121.22412310
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20157942
39Nitrogen metabolism_Homo sapiens_hsa009101.12419855
40Melanogenesis_Homo sapiens_hsa049161.08406456
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06432827
42Butanoate metabolism_Homo sapiens_hsa006501.01215288
43cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99747451
44Phototransduction_Homo sapiens_hsa047440.99120126
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98571254
46Oocyte meiosis_Homo sapiens_hsa041140.95764874
47Dorso-ventral axis formation_Homo sapiens_hsa043200.94331062
48Endometrial cancer_Homo sapiens_hsa052130.92199579
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.91361488
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88103788
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.84471003
52Collecting duct acid secretion_Homo sapiens_hsa049660.83531277
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80870613
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.80765562
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80316593
56Hedgehog signaling pathway_Homo sapiens_hsa043400.80048028
57Choline metabolism in cancer_Homo sapiens_hsa052310.79012358
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78146012
59mTOR signaling pathway_Homo sapiens_hsa041500.77002778
60MAPK signaling pathway_Homo sapiens_hsa040100.74346809
61Pancreatic secretion_Homo sapiens_hsa049720.74173153
62Thyroid hormone synthesis_Homo sapiens_hsa049180.73516234
63VEGF signaling pathway_Homo sapiens_hsa043700.73081438
64Hippo signaling pathway_Homo sapiens_hsa043900.71104960
65Dilated cardiomyopathy_Homo sapiens_hsa054140.70160775
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69363937
67Renal cell carcinoma_Homo sapiens_hsa052110.68623768
68Colorectal cancer_Homo sapiens_hsa052100.67731706
69Alcoholism_Homo sapiens_hsa050340.66003446
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65606934
71Ras signaling pathway_Homo sapiens_hsa040140.64867266
72Vibrio cholerae infection_Homo sapiens_hsa051100.64504957
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64357491
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64264024
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62484406
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.62289264
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61643663
78Cardiac muscle contraction_Homo sapiens_hsa042600.61219455
79Non-small cell lung cancer_Homo sapiens_hsa052230.60494512
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59974229
81Rap1 signaling pathway_Homo sapiens_hsa040150.59877699
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59435633
83Glucagon signaling pathway_Homo sapiens_hsa049220.58167687
84Insulin signaling pathway_Homo sapiens_hsa049100.57567385
85Endocytosis_Homo sapiens_hsa041440.57247488
86Basal cell carcinoma_Homo sapiens_hsa052170.57061202
87Wnt signaling pathway_Homo sapiens_hsa043100.55794775
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55677931
89Steroid biosynthesis_Homo sapiens_hsa001000.53632156
90Prion diseases_Homo sapiens_hsa050200.53153560
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51796987
92Alzheimers disease_Homo sapiens_hsa050100.51750068
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49353395
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49316955
95Bile secretion_Homo sapiens_hsa049760.48759570
96Type I diabetes mellitus_Homo sapiens_hsa049400.47595128
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47025923
98Circadian rhythm_Homo sapiens_hsa047100.45726278
99Ether lipid metabolism_Homo sapiens_hsa005650.43353902
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41246289
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40858981
102Regulation of autophagy_Homo sapiens_hsa041400.40852148
103Inositol phosphate metabolism_Homo sapiens_hsa005620.40838224
104Chemokine signaling pathway_Homo sapiens_hsa040620.40280695
105Parkinsons disease_Homo sapiens_hsa050120.39680418
106Prolactin signaling pathway_Homo sapiens_hsa049170.39556444
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38877190
108Ovarian steroidogenesis_Homo sapiens_hsa049130.37742334
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37042607
110Oxidative phosphorylation_Homo sapiens_hsa001900.36709317
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36701151
112AMPK signaling pathway_Homo sapiens_hsa041520.35791854
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.32419690
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32235025
115Tight junction_Homo sapiens_hsa045300.32074374
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30388371
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29403368
118Fatty acid biosynthesis_Homo sapiens_hsa000610.28488905

Most similar genes based on co-expression Upload to Enrichr

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